SMYD4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand renaturation (GO:0000733)6.00411546
2behavioral response to nicotine (GO:0035095)5.39528894
3kinetochore assembly (GO:0051382)4.13278122
4doxorubicin metabolic process (GO:0044598)4.01961636
5daunorubicin metabolic process (GO:0044597)4.01961636
6polyketide metabolic process (GO:0030638)4.01961636
7piRNA metabolic process (GO:0034587)3.97879623
8telomere maintenance via semi-conservative replication (GO:0032201)3.95543858
9L-fucose catabolic process (GO:0042355)3.83534425
10fucose catabolic process (GO:0019317)3.83534425
11L-fucose metabolic process (GO:0042354)3.83534425
12replication fork processing (GO:0031297)3.81893117
13kinetochore organization (GO:0051383)3.74976863
14protein K6-linked ubiquitination (GO:0085020)3.71613000
15somatic hypermutation of immunoglobulin genes (GO:0016446)3.69728482
16somatic diversification of immune receptors via somatic mutation (GO:0002566)3.69728482
17regulation of posttranscriptional gene silencing (GO:0060147)3.65238020
18regulation of gene silencing by miRNA (GO:0060964)3.65238020
19regulation of gene silencing by RNA (GO:0060966)3.65238020
20maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.64435118
21rRNA catabolic process (GO:0016075)3.60897804
22DNA ligation (GO:0006266)3.60142635
23double-strand break repair via homologous recombination (GO:0000724)3.59930526
24DNA deamination (GO:0045006)3.56824782
25nucleotide-excision repair, DNA gap filling (GO:0006297)3.55424656
26negative regulation of translation, ncRNA-mediated (GO:0040033)3.54076900
27regulation of translation, ncRNA-mediated (GO:0045974)3.54076900
28negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.54076900
29RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.52646479
30tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.52646479
31DNA replication initiation (GO:0006270)3.52153230
32tRNA methylation (GO:0030488)3.48089952
33negative regulation of DNA-dependent DNA replication (GO:2000104)3.47733704
34regulation of double-strand break repair via homologous recombination (GO:0010569)3.46758229
35regulation of nuclear cell cycle DNA replication (GO:0033262)3.46198248
36mesenchymal cell differentiation involved in kidney development (GO:0072161)3.45455992
37mesenchymal cell differentiation involved in renal system development (GO:2001012)3.45455992
38DNA strand elongation involved in DNA replication (GO:0006271)3.43584059
39telomere maintenance via telomere lengthening (GO:0010833)3.43517934
40intra-S DNA damage checkpoint (GO:0031573)3.42833129
41DNA replication checkpoint (GO:0000076)3.40816720
42telomere maintenance via recombination (GO:0000722)3.35297166
43DNA strand elongation (GO:0022616)3.33579148
44pseudouridine synthesis (GO:0001522)3.30861086
45centriole assembly (GO:0098534)3.28551252
46establishment of integrated proviral latency (GO:0075713)3.28158504
47kynurenine metabolic process (GO:0070189)3.27507967
48protein polyglutamylation (GO:0018095)3.24961693
49replicative senescence (GO:0090399)3.23535872
50neural tube formation (GO:0001841)3.22673615
51regulation of hippo signaling (GO:0035330)3.21756573
52base-excision repair, AP site formation (GO:0006285)3.18625715
53indolalkylamine metabolic process (GO:0006586)3.18276307
54mitotic recombination (GO:0006312)3.18172958
557-methylguanosine RNA capping (GO:0009452)3.16284246
56RNA capping (GO:0036260)3.16284246
577-methylguanosine mRNA capping (GO:0006370)3.15373781
58indole-containing compound catabolic process (GO:0042436)3.14266818
59indolalkylamine catabolic process (GO:0046218)3.14266818
60tryptophan catabolic process (GO:0006569)3.14266818
61response to redox state (GO:0051775)3.13978818
62ubiquinone biosynthetic process (GO:0006744)3.12777987
63deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.10685982
64maturation of 5.8S rRNA (GO:0000460)3.10180094
65mismatch repair (GO:0006298)3.06448716
66transcription-coupled nucleotide-excision repair (GO:0006283)3.05859573
67DNA methylation involved in gamete generation (GO:0043046)3.05533576
68regulation of mitotic spindle checkpoint (GO:1903504)3.04221383
69regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.04221383
70pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.03972738
71presynaptic membrane organization (GO:0097090)3.00980461
72presynaptic membrane assembly (GO:0097105)2.99176596
73detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.97898146
74chromatin remodeling at centromere (GO:0031055)2.97583230
75epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.95562723
76CENP-A containing nucleosome assembly (GO:0034080)2.95256880
77negative regulation of telomere maintenance (GO:0032205)2.94860917
78protein complex biogenesis (GO:0070271)2.93970258
79pyrimidine nucleotide catabolic process (GO:0006244)2.93957283
80RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.91750928
81intraciliary transport (GO:0042073)2.89893434
82ubiquinone metabolic process (GO:0006743)2.89338313
83regulation of mitochondrial translation (GO:0070129)2.88931209
84cellular ketone body metabolic process (GO:0046950)2.88608345
85positive regulation of protein homodimerization activity (GO:0090073)2.87757911
86tryptophan metabolic process (GO:0006568)2.87359010
87transcription elongation from RNA polymerase I promoter (GO:0006362)2.86839994
88synapsis (GO:0007129)2.84893812
89axoneme assembly (GO:0035082)2.84765488
90ncRNA catabolic process (GO:0034661)2.84739931
91mitochondrial respiratory chain complex assembly (GO:0033108)2.84470921
92cytochrome complex assembly (GO:0017004)2.83209749
93cullin deneddylation (GO:0010388)2.81987141
94protein-cofactor linkage (GO:0018065)2.81464984
95DNA synthesis involved in DNA repair (GO:0000731)2.81119538
96platelet dense granule organization (GO:0060155)2.79092770
97pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.78927634
98termination of RNA polymerase I transcription (GO:0006363)2.78690014
99microtubule depolymerization (GO:0007019)2.77884259
100protein K11-linked deubiquitination (GO:0035871)2.77725993
101meiotic chromosome segregation (GO:0045132)2.76314881
102translesion synthesis (GO:0019985)2.76160245
103termination of RNA polymerase III transcription (GO:0006386)2.75875123
104transcription elongation from RNA polymerase III promoter (GO:0006385)2.75875123
105DNA catabolic process, exonucleolytic (GO:0000738)2.73242443
106deoxyribonucleotide biosynthetic process (GO:0009263)2.72725825
107DNA double-strand break processing (GO:0000729)2.72414776
108mitochondrial respiratory chain complex I assembly (GO:0032981)2.71555475
109NADH dehydrogenase complex assembly (GO:0010257)2.71555475
110mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.71555475
111nonmotile primary cilium assembly (GO:0035058)2.70665640
112protein localization to cilium (GO:0061512)2.70638344
113energy homeostasis (GO:0097009)2.69238690
114dentate gyrus development (GO:0021542)2.69019972
115regulation of telomere maintenance (GO:0032204)2.67146666
116epithelial cilium movement (GO:0003351)2.66842712
117nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.66230183
118exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.65916619
119telomere organization (GO:0032200)2.64943815
120DNA damage induced protein phosphorylation (GO:0006975)2.64123999
121telomere maintenance (GO:0000723)2.64101864
122multicellular organism reproduction (GO:0032504)2.63782623
123viral mRNA export from host cell nucleus (GO:0046784)2.63214507
124establishment of viral latency (GO:0019043)2.62474685
125G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.61316612
126tRNA modification (GO:0006400)2.60970173
127response to pheromone (GO:0019236)2.60205499
128water-soluble vitamin biosynthetic process (GO:0042364)2.59959745
129postreplication repair (GO:0006301)2.59743115
130DNA damage response, detection of DNA damage (GO:0042769)2.59567383
131ketone body metabolic process (GO:1902224)2.59537462
132regulation of mesoderm development (GO:2000380)2.58586125
133DNA recombination (GO:0006310)2.58564409
134transcription from RNA polymerase I promoter (GO:0006360)2.58382933
135protein deneddylation (GO:0000338)2.57078900
136centriole replication (GO:0007099)2.55852602
137DNA-dependent DNA replication (GO:0006261)2.55722424
138proteasome assembly (GO:0043248)2.55335197
139nucleotide-excision repair (GO:0006289)2.54869779
140telomere maintenance via telomerase (GO:0007004)2.53443223
141male meiosis I (GO:0007141)2.51385232
142response to X-ray (GO:0010165)2.51369821
143regulation of centriole replication (GO:0046599)2.50178806
144DNA demethylation (GO:0080111)2.48729670
145DNA replication-dependent nucleosome organization (GO:0034723)2.48525429
146DNA replication-dependent nucleosome assembly (GO:0006335)2.48525429
147quinone biosynthetic process (GO:1901663)2.46895096
148regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.45635938
149female gonad development (GO:0008585)2.45206927
150male meiosis (GO:0007140)2.45172464
151detection of light stimulus involved in visual perception (GO:0050908)2.44835491
152detection of light stimulus involved in sensory perception (GO:0050962)2.44835491
153respiratory chain complex IV assembly (GO:0008535)2.43856759
154preassembly of GPI anchor in ER membrane (GO:0016254)2.43588098
155double-strand break repair (GO:0006302)2.43502248
156centrosome organization (GO:0051297)2.43344644
157histone H3-K9 methylation (GO:0051567)2.43140698
158cilium organization (GO:0044782)2.43099753
159DNA methylation or demethylation (GO:0044728)2.43088146
160tRNA processing (GO:0008033)2.42883831
161GPI anchor biosynthetic process (GO:0006506)2.42792464
162cell differentiation involved in metanephros development (GO:0072202)2.42505758
163DNA modification (GO:0006304)2.42321173
164reciprocal meiotic recombination (GO:0007131)2.41817380
165reciprocal DNA recombination (GO:0035825)2.41817380
166poly(A)+ mRNA export from nucleus (GO:0016973)2.41481796
167transcription initiation from RNA polymerase I promoter (GO:0006361)2.41173436
168kidney morphogenesis (GO:0060993)2.39823470
169regulation of meiosis I (GO:0060631)2.39407963
170mitotic metaphase plate congression (GO:0007080)2.38218564
171snRNA processing (GO:0016180)2.37063023
172startle response (GO:0001964)2.36191551
173RNA-dependent DNA replication (GO:0006278)2.35396507
174neuron cell-cell adhesion (GO:0007158)2.34643341
175aminoglycoside antibiotic metabolic process (GO:0030647)2.33637378
176cilium assembly (GO:0042384)2.32606682
177recombinational repair (GO:0000725)2.31476891

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.59787572
2ZNF274_21170338_ChIP-Seq_K562_Hela4.22546667
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.16916614
4GBX2_23144817_ChIP-Seq_PC3_Human3.02111319
5MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.78447287
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.73945912
7ELF1_17652178_ChIP-ChIP_JURKAT_Human2.51988426
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.45543064
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.44247863
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.33549158
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.24539993
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.12099127
13* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.07626551
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.03072005
15GABP_17652178_ChIP-ChIP_JURKAT_Human1.98639737
16ZFP57_27257070_Chip-Seq_ESCs_Mouse1.97671113
17CTBP2_25329375_ChIP-Seq_LNCAP_Human1.93995445
18PCGF2_27294783_Chip-Seq_ESCs_Mouse1.93401435
19RBPJ_22232070_ChIP-Seq_NCS_Mouse1.91162732
20EST1_17652178_ChIP-ChIP_JURKAT_Human1.90484982
21BMI1_23680149_ChIP-Seq_NPCS_Mouse1.89230697
22FUS_26573619_Chip-Seq_HEK293_Human1.83224772
23ER_23166858_ChIP-Seq_MCF-7_Human1.82721135
24MYC_18940864_ChIP-ChIP_HL60_Human1.82058306
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.80610621
26* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.80361165
27EWS_26573619_Chip-Seq_HEK293_Human1.80101028
28SMAD_19615063_ChIP-ChIP_OVARY_Human1.76292624
29IRF1_19129219_ChIP-ChIP_H3396_Human1.75331222
30HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.74980724
31TP63_19390658_ChIP-ChIP_HaCaT_Human1.72201469
32RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72170500
33TAF15_26573619_Chip-Seq_HEK293_Human1.69687185
34NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.68160472
35POU5F1_16153702_ChIP-ChIP_HESCs_Human1.66761336
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.64663575
37YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59423617
38FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.56753026
39CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.56239382
40MYC_18555785_ChIP-Seq_MESCs_Mouse1.54913414
41MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.54394895
42ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.52414021
43FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.51100905
44TP53_22573176_ChIP-Seq_HFKS_Human1.51100824
45VDR_22108803_ChIP-Seq_LS180_Human1.50034669
46SUZ12_27294783_Chip-Seq_NPCs_Mouse1.48550504
47STAT3_23295773_ChIP-Seq_U87_Human1.48274817
48RNF2_27304074_Chip-Seq_NSC_Mouse1.47831388
49TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47502204
50POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.47502204
51IGF1R_20145208_ChIP-Seq_DFB_Human1.46911289
52NFE2_27457419_Chip-Seq_LIVER_Mouse1.46881036
53EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.45714156
54FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.45389468
55PCGF2_27294783_Chip-Seq_NPCs_Mouse1.45042735
56NANOG_18555785_Chip-Seq_ESCs_Mouse1.41700528
57STAT3_18555785_Chip-Seq_ESCs_Mouse1.40967686
58* SRF_21415370_ChIP-Seq_HL-1_Mouse1.39985882
59TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.39861134
60ELK1_19687146_ChIP-ChIP_HELA_Human1.39438321
61UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.38037473
62E2F1_18555785_Chip-Seq_ESCs_Mouse1.37268780
63SUZ12_18555785_Chip-Seq_ESCs_Mouse1.37103627
64MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.36463247
65P300_19829295_ChIP-Seq_ESCs_Human1.36075178
66EZH2_22144423_ChIP-Seq_EOC_Human1.34813242
67AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.34463936
68* TCF4_23295773_ChIP-Seq_U87_Human1.34241131
69P53_22387025_ChIP-Seq_ESCs_Mouse1.33906171
70FOXP3_21729870_ChIP-Seq_TREG_Human1.32956232
71AR_21572438_ChIP-Seq_LNCaP_Human1.31998817
72PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.31982631
73THAP11_20581084_ChIP-Seq_MESCs_Mouse1.31290378
74CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.31274787
75NMYC_18555785_Chip-Seq_ESCs_Mouse1.30443685
76CBP_20019798_ChIP-Seq_JUKART_Human1.30359665
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30359665
78SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29119036
79EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.28810412
80GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.27313650
81VDR_23849224_ChIP-Seq_CD4+_Human1.24132601
82ETS1_20019798_ChIP-Seq_JURKAT_Human1.22727265
83* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.22142136
84HOXB7_26014856_ChIP-Seq_BT474_Human1.21089269
85EZH2_27294783_Chip-Seq_NPCs_Mouse1.20778123
86GATA3_21878914_ChIP-Seq_MCF-7_Human1.20519390
87P300_18555785_Chip-Seq_ESCs_Mouse1.20443975
88MYC_19030024_ChIP-ChIP_MESCs_Mouse1.20422550
89* AR_25329375_ChIP-Seq_VCAP_Human1.19791630
90CMYC_18555785_Chip-Seq_ESCs_Mouse1.18132175
91ZFX_18555785_Chip-Seq_ESCs_Mouse1.17960947
92RUNX1_27457419_Chip-Seq_LIVER_Mouse1.17939104
93TCF4_22108803_ChIP-Seq_LS180_Human1.17123001
94HOXB4_20404135_ChIP-ChIP_EML_Mouse1.16319922
95SOX2_18555785_ChIP-Seq_MESCs_Mouse1.16143176
96BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.15206003
97MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.15060610
98KLF4_18555785_Chip-Seq_ESCs_Mouse1.14687985
99GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.14259123
100SOX2_18555785_Chip-Seq_ESCs_Mouse1.13707141
101FOXA1_25329375_ChIP-Seq_VCAP_Human1.12985348
102FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12985348
103CBX2_27304074_Chip-Seq_ESCs_Mouse1.12642232
104NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12530299
105SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11332031
106NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.10798030
107ETV2_25802403_ChIP-Seq_MESCs_Mouse1.09958293
108OCT4_18555785_Chip-Seq_ESCs_Mouse1.09950919
109SOX2_19829295_ChIP-Seq_ESCs_Human1.09690404
110NANOG_19829295_ChIP-Seq_ESCs_Human1.09690404
111KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09399150
112PU1_27457419_Chip-Seq_LIVER_Mouse1.08467595
113YY1_21170310_ChIP-Seq_MESCs_Mouse1.08318757
114PIAS1_25552417_ChIP-Seq_VCAP_Human1.07807759
115ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.07781417
116* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.07772453
117PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07395721
118SMAD4_21741376_ChIP-Seq_EPCs_Human1.07110982
119BCAT_22108803_ChIP-Seq_LS180_Human1.06721880
120POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.06124395
121E2F1_21310950_ChIP-Seq_MCF-7_Human1.05297837
122RUNX2_22187159_ChIP-Seq_PCA_Human1.04964252
123SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.04152236
124TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04052515
125NCOR_22424771_ChIP-Seq_293T_Human1.03975883
126CTBP1_25329375_ChIP-Seq_LNCAP_Human1.03621516
127TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03467594
128ESRRB_18555785_Chip-Seq_ESCs_Mouse1.02752808
129PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01291972
130AR_20517297_ChIP-Seq_VCAP_Human1.00554865
131PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.00202451
132SMAD4_21799915_ChIP-Seq_A2780_Human0.99743593
133CTCF_18555785_Chip-Seq_ESCs_Mouse0.99650165
134CREB1_15753290_ChIP-ChIP_HEK293T_Human0.99401720
135SALL1_21062744_ChIP-ChIP_HESCs_Human0.99256487
136SMAD3_21741376_ChIP-Seq_EPCs_Human0.99060496
137TP53_16413492_ChIP-PET_HCT116_Human0.98668587
138AUTS2_25519132_ChIP-Seq_293T-REX_Human0.98324997
139MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97402009
140PRDM14_20953172_ChIP-Seq_ESCs_Human0.96837699
141ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96550738
142TAL1_26923725_Chip-Seq_HPCs_Mouse0.96469381
143SOX2_16153702_ChIP-ChIP_HESCs_Human0.96089616
144FOXA1_21572438_ChIP-Seq_LNCaP_Human0.95608650
145NOTCH1_21737748_ChIP-Seq_TLL_Human0.94749131
146TTF2_22483619_ChIP-Seq_HELA_Human0.94550649
147DCP1A_22483619_ChIP-Seq_HELA_Human0.94035076
148SMAD1_18555785_Chip-Seq_ESCs_Mouse0.93967268
149ERA_21632823_ChIP-Seq_H3396_Human0.93269391
150CRX_20693478_ChIP-Seq_RETINA_Mouse0.91734526
151FLI1_21867929_ChIP-Seq_TH2_Mouse0.91080423

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.17631329
2MP0001188_hyperpigmentation3.98828243
3MP0001986_abnormal_taste_sensitivity3.53751753
4MP0003646_muscle_fatigue3.30949166
5MP0008058_abnormal_DNA_repair3.03811843
6MP0010094_abnormal_chromosome_stability2.84143895
7MP0008877_abnormal_DNA_methylation2.77346631
8MP0000566_synostosis2.69673076
9MP0005423_abnormal_somatic_nervous2.62885780
10MP0003136_yellow_coat_color2.62607606
11MP0003693_abnormal_embryo_hatching2.43946979
12MP0003787_abnormal_imprinting2.24084330
13MP0005171_absent_coat_pigmentation2.17014779
14MP0000427_abnormal_hair_cycle2.14342327
15MP0010386_abnormal_urinary_bladder2.08330165
16MP0003786_premature_aging2.06617081
17MP0000015_abnormal_ear_pigmentation2.06467615
18MP0005646_abnormal_pituitary_gland1.99026605
19MP0004147_increased_porphyrin_level1.97424619
20MP0003195_calcinosis1.97192306
21MP0001529_abnormal_vocalization1.96227821
22MP0008057_abnormal_DNA_replication1.92796363
23MP0000569_abnormal_digit_pigmentation1.92549251
24MP0003111_abnormal_nucleus_morphology1.92485019
25MP0008260_abnormal_autophagy1.80808479
26MP0005645_abnormal_hypothalamus_physiol1.80404653
27MP0002837_dystrophic_cardiac_calcinosis1.79105468
28MP0004145_abnormal_muscle_electrophysio1.77805568
29MP0003880_abnormal_central_pattern1.76839453
30MP0000678_abnormal_parathyroid_gland1.74764502
31MP0003121_genomic_imprinting1.74326618
32MP0002102_abnormal_ear_morphology1.71591150
33MP0005075_abnormal_melanosome_morpholog1.67531147
34MP0004381_abnormal_hair_follicle1.61248800
35MP0008995_early_reproductive_senescence1.58169921
36MP0006072_abnormal_retinal_apoptosis1.58041006
37MP0006276_abnormal_autonomic_nervous1.55123527
38MP0003077_abnormal_cell_cycle1.50569600
39MP0004133_heterotaxia1.46432556
40MP0005499_abnormal_olfactory_system1.46063303
41MP0005394_taste/olfaction_phenotype1.46063303
42MP0008872_abnormal_physiological_respon1.44160650
43MP0009046_muscle_twitch1.42733671
44MP0002132_abnormal_respiratory_system1.39918075
45MP0005379_endocrine/exocrine_gland_phen1.38316030
46MP0002638_abnormal_pupillary_reflex1.37399166
47MP0008007_abnormal_cellular_replicative1.37009840
48MP0008789_abnormal_olfactory_epithelium1.35875303
49MP0002163_abnormal_gland_morphology1.35352752
50MP0003941_abnormal_skin_development1.33241783
51MP0005551_abnormal_eye_electrophysiolog1.31933886
52MP0000372_irregular_coat_pigmentation1.31294644
53MP0005409_darkened_coat_color1.29687460
54MP0005084_abnormal_gallbladder_morpholo1.28561946
55MP0003122_maternal_imprinting1.26992686
56MP0005174_abnormal_tail_pigmentation1.26328911
57MP0001968_abnormal_touch/_nociception1.25248375
58MP0008875_abnormal_xenobiotic_pharmacok1.25142934
59MP0000631_abnormal_neuroendocrine_gland1.24633601
60MP0002928_abnormal_bile_duct1.24417177
61MP0001502_abnormal_circadian_rhythm1.23423050
62MP0009697_abnormal_copulation1.22905661
63MP0000383_abnormal_hair_follicle1.22260182
64MP0002095_abnormal_skin_pigmentation1.21911035
65MP0001485_abnormal_pinna_reflex1.19159913
66MP0001186_pigmentation_phenotype1.18687949
67MP0002736_abnormal_nociception_after1.18491411
68MP0001293_anophthalmia1.16341256
69MP0008932_abnormal_embryonic_tissue1.16256696
70MP0005253_abnormal_eye_physiology1.14541731
71MP0001984_abnormal_olfaction1.13283524
72MP0004043_abnormal_pH_regulation1.12534329
73MP0005389_reproductive_system_phenotype1.12200318
74MP0002234_abnormal_pharynx_morphology1.11340809
75MP0004885_abnormal_endolymph1.10713665
76MP0002751_abnormal_autonomic_nervous1.10064083
77MP0003011_delayed_dark_adaptation1.09139525
78MP0008775_abnormal_heart_ventricle1.08501652
79MP0003119_abnormal_digestive_system1.07906139
80MP0003937_abnormal_limbs/digits/tail_de1.07426012
81MP0001919_abnormal_reproductive_system1.07356783
82MP0004130_abnormal_muscle_cell1.07208480
83MP0002160_abnormal_reproductive_system1.06143560
84MP0003890_abnormal_embryonic-extraembry1.05301210
85MP0002277_abnormal_respiratory_mucosa1.05148489
86MP0000681_abnormal_thyroid_gland1.04917759
87MP0002653_abnormal_ependyma_morphology1.04823213
88MP0002210_abnormal_sex_determination1.04782882
89MP0002272_abnormal_nervous_system1.04662009
90MP0006035_abnormal_mitochondrial_morpho1.03952105
91MP0005410_abnormal_fertilization1.03186424
92MP0001501_abnormal_sleep_pattern1.02828906
93MP0004957_abnormal_blastocyst_morpholog1.02766438
94MP0001324_abnormal_eye_pigmentation1.01833896
95MP0003878_abnormal_ear_physiology1.01022959
96MP0005377_hearing/vestibular/ear_phenot1.01022959
97MP0002075_abnormal_coat/hair_pigmentati0.99301447
98MP0004142_abnormal_muscle_tone0.98839473
99MP0002938_white_spotting0.98658995
100MP0002572_abnormal_emotion/affect_behav0.97702925
101MP0002138_abnormal_hepatobiliary_system0.97385611
102MP0000778_abnormal_nervous_system0.96303156
103MP0000026_abnormal_inner_ear0.95050710
104MP0000647_abnormal_sebaceous_gland0.94194732
105MP0004215_abnormal_myocardial_fiber0.92492417
106MP0003567_abnormal_fetal_cardiomyocyte0.91937832
107MP0002557_abnormal_social/conspecific_i0.91354600
108MP0005195_abnormal_posterior_eye0.91028213
109MP0002067_abnormal_sensory_capabilities0.88954856
110MP0000049_abnormal_middle_ear0.87257936
111MP0002735_abnormal_chemical_nociception0.86982559
112MP0004742_abnormal_vestibular_system0.86471781
113MP0002249_abnormal_larynx_morphology0.86185388
114MP0001486_abnormal_startle_reflex0.84714194
115MP0009745_abnormal_behavioral_response0.84063094
116MP0002733_abnormal_thermal_nociception0.82909933
117MP0001286_abnormal_eye_development0.79847673
118MP0004924_abnormal_behavior0.79624314
119MP0005386_behavior/neurological_phenoty0.79624314
120MP0005391_vision/eye_phenotype0.78524187
121MP0005266_abnormal_metabolism0.78446669
122MP0002184_abnormal_innervation0.78280559
123MP0002177_abnormal_outer_ear0.77734311
124MP0001145_abnormal_male_reproductive0.76158106
125MP0002063_abnormal_learning/memory/cond0.75243444
126MP0000653_abnormal_sex_gland0.74667590
127MP0001905_abnormal_dopamine_level0.73178526
128MP0002396_abnormal_hematopoietic_system0.72646777
129MP0001119_abnormal_female_reproductive0.71865023
130MP0001963_abnormal_hearing_physiology0.71170302
131MP0002876_abnormal_thyroid_physiology0.71122672
132MP0001929_abnormal_gametogenesis0.70230921
133MP0002752_abnormal_somatic_nervous0.69447813
134MP0004782_abnormal_surfactant_physiolog0.68751139
135MP0003718_maternal_effect0.68426083
136MP0003123_paternal_imprinting0.66198981
137MP0003938_abnormal_ear_development0.66095260
138MP0003698_abnormal_male_reproductive0.66074597
139MP0001835_abnormal_antigen_presentation0.65715977
140MP0003635_abnormal_synaptic_transmissio0.65506480
141MP0000490_abnormal_crypts_of0.65039163

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.82011259
2Chromsome breakage (HP:0040012)4.45645363
3Abnormal hair whorl (HP:0010721)3.89764725
4Birth length less than 3rd percentile (HP:0003561)3.85972762
5Type II lissencephaly (HP:0007260)3.75325825
6True hermaphroditism (HP:0010459)3.36131681
7Duplicated collecting system (HP:0000081)3.35769864
8Abnormality of the renal collecting system (HP:0004742)3.20009303
9Pancreatic fibrosis (HP:0100732)2.99793927
10Fair hair (HP:0002286)2.96769813
11Abnormality of the renal medulla (HP:0100957)2.90280822
12Pancreatic cysts (HP:0001737)2.88768782
13Septo-optic dysplasia (HP:0100842)2.86908799
14Cerebellar dysplasia (HP:0007033)2.84972996
15Hyperventilation (HP:0002883)2.80361336
16Pendular nystagmus (HP:0012043)2.80090746
17Abnormality of the renal cortex (HP:0011035)2.78403117
18Medial flaring of the eyebrow (HP:0010747)2.74150494
19Abnormality of chromosome stability (HP:0003220)2.73760507
20Colon cancer (HP:0003003)2.72510349
21Aplasia/Hypoplasia of the uvula (HP:0010293)2.68445130
22Chronic hepatic failure (HP:0100626)2.66614255
23Cystic liver disease (HP:0006706)2.65811702
24Lissencephaly (HP:0001339)2.65411788
25Abnormality of the preputium (HP:0100587)2.65094400
26Meckel diverticulum (HP:0002245)2.65091809
27Intestinal atresia (HP:0011100)2.63000393
28Generalized hypopigmentation of hair (HP:0011358)2.62117966
29Febrile seizures (HP:0002373)2.61374193
30Microvesicular hepatic steatosis (HP:0001414)2.60742527
31Hypoplasia of the fovea (HP:0007750)2.59043517
32Aplasia/Hypoplasia of the fovea (HP:0008060)2.59043517
33Abnormality of the ileum (HP:0001549)2.58029816
34Type I transferrin isoform profile (HP:0003642)2.57084443
35Thyroid-stimulating hormone excess (HP:0002925)2.51261905
36Fibular aplasia (HP:0002990)2.49972435
37Preaxial hand polydactyly (HP:0001177)2.46244759
38Nephrogenic diabetes insipidus (HP:0009806)2.41672697
39Duplication of thumb phalanx (HP:0009942)2.41611686
40Rectal fistula (HP:0100590)2.40874972
41Rectovaginal fistula (HP:0000143)2.40874972
42Gait imbalance (HP:0002141)2.37620851
43Congenital primary aphakia (HP:0007707)2.36880124
44Optic nerve hypoplasia (HP:0000609)2.33947239
45Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.33606866
46Abnormality of alanine metabolism (HP:0010916)2.33606866
47Hyperalaninemia (HP:0003348)2.33606866
48Anencephaly (HP:0002323)2.33429896
49Progressive inability to walk (HP:0002505)2.32747779
50Tubular atrophy (HP:0000092)2.26566508
51Hypoplasia of the capital femoral epiphysis (HP:0003090)2.25782627
52Absent radius (HP:0003974)2.23691839
53Molar tooth sign on MRI (HP:0002419)2.23319623
54Abnormality of midbrain morphology (HP:0002418)2.23319623
55Aplasia/Hypoplasia of the tongue (HP:0010295)2.23148219
56Inability to walk (HP:0002540)2.22784879
57Abnormality of the pons (HP:0007361)2.22252528
58Bile duct proliferation (HP:0001408)2.21415580
59Abnormal biliary tract physiology (HP:0012439)2.21415580
60Absent thumb (HP:0009777)2.20542715
61Postaxial foot polydactyly (HP:0001830)2.19857369
62Premature graying of hair (HP:0002216)2.17759480
63Bone marrow hypocellularity (HP:0005528)2.16075443
64Hypoplasia of the pons (HP:0012110)2.14562749
65Triphalangeal thumb (HP:0001199)2.14484400
66Retinal dysplasia (HP:0007973)2.14262665
67Renal cortical cysts (HP:0000803)2.11633972
68Osteomalacia (HP:0002749)2.11515827
69Abnormality of the fovea (HP:0000493)2.11047198
70Absent forearm bone (HP:0003953)2.10431612
71Aplasia involving forearm bones (HP:0009822)2.10431612
72Broad-based gait (HP:0002136)2.09965090
73Aplasia cutis congenita (HP:0001057)2.09866048
74Intestinal fistula (HP:0100819)2.09451792
75Aplasia/Hypoplasia of the tibia (HP:0005772)2.08390179
76Attenuation of retinal blood vessels (HP:0007843)2.08213097
77Breast hypoplasia (HP:0003187)2.07961121
78Reticulocytopenia (HP:0001896)2.07821412
79Patellar aplasia (HP:0006443)2.06913837
80Oligodactyly (hands) (HP:0001180)2.06819152
81Abnormality of DNA repair (HP:0003254)2.06016556
82Ectopic kidney (HP:0000086)2.05157374
83Epileptic encephalopathy (HP:0200134)2.04900466
84Hyperglycinuria (HP:0003108)2.04782005
85Male pseudohermaphroditism (HP:0000037)2.04090934
86Rough bone trabeculation (HP:0100670)2.03776893
87Aplasia/hypoplasia of the uterus (HP:0008684)2.03769033
88Focal motor seizures (HP:0011153)2.02886499
89Gaze-evoked nystagmus (HP:0000640)2.02830299
90Genetic anticipation (HP:0003743)2.02324722
91Renal Fanconi syndrome (HP:0001994)2.01968880
92Aplasia/Hypoplasia of the spleen (HP:0010451)2.01756210
93Abolished electroretinogram (ERG) (HP:0000550)2.00727156
94Clumsiness (HP:0002312)1.99829062
95Dandy-Walker malformation (HP:0001305)1.98594576
96Nephroblastoma (Wilms tumor) (HP:0002667)1.98210665
97Stomach cancer (HP:0012126)1.98170663
98Poor coordination (HP:0002370)1.97485512
99Small hand (HP:0200055)1.95481397
100Aganglionic megacolon (HP:0002251)1.94869970
101Abnormal drinking behavior (HP:0030082)1.93625999
102Polydipsia (HP:0001959)1.93625999
103Congenital hepatic fibrosis (HP:0002612)1.93307822
104Occipital encephalocele (HP:0002085)1.92866298
105Facial cleft (HP:0002006)1.92299912
106Large for gestational age (HP:0001520)1.92163018
107Tubulointerstitial nephritis (HP:0001970)1.91979585
108Protruding tongue (HP:0010808)1.91514866
109Abnormality of the nasolacrimal system (HP:0000614)1.90178841
110Embryonal renal neoplasm (HP:0011794)1.89928204
111Pachygyria (HP:0001302)1.89540039
112Aplasia/Hypoplasia of the patella (HP:0006498)1.89140078
113Abnormality of the septum pellucidum (HP:0007375)1.89038802
114Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.88847913
115Nephronophthisis (HP:0000090)1.88789048
116Congenital stationary night blindness (HP:0007642)1.88176792
117Gastroesophageal reflux (HP:0002020)1.86527481
118Furrowed tongue (HP:0000221)1.86032183
119Small intestinal stenosis (HP:0012848)1.85760406
120Duodenal stenosis (HP:0100867)1.85760406
1213-Methylglutaconic aciduria (HP:0003535)1.85355162
122Sclerocornea (HP:0000647)1.84560174
123Asplenia (HP:0001746)1.84461592
124Median cleft lip (HP:0000161)1.84460555
125Congenital, generalized hypertrichosis (HP:0004540)1.84074770
126Clubbing of toes (HP:0100760)1.83804230
127Vaginal fistula (HP:0004320)1.83496799
128Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.82618947
129Abnormality of the carotid arteries (HP:0005344)1.81406125
130Impulsivity (HP:0100710)1.81203918
131Oligohydramnios (HP:0001562)1.80154889
132Abnormality of the labia minora (HP:0012880)1.79598194
133Volvulus (HP:0002580)1.78652531
134Vaginal atresia (HP:0000148)1.77849316
135Fetal akinesia sequence (HP:0001989)1.77795503
136Septate vagina (HP:0001153)1.77562667
137Absent septum pellucidum (HP:0001331)1.76493514
138Severe muscular hypotonia (HP:0006829)1.76421436
139Sloping forehead (HP:0000340)1.75988427
140Abnormal ciliary motility (HP:0012262)1.75505162
141Genital tract atresia (HP:0001827)1.75492408
142Astigmatism (HP:0000483)1.74415759
143Hypergonadotropic hypogonadism (HP:0000815)1.73941255
144Hypothermia (HP:0002045)1.73469170
145Increased corneal curvature (HP:0100692)1.73421409
146Keratoconus (HP:0000563)1.73421409
147Prostate neoplasm (HP:0100787)1.73342332
148Severe visual impairment (HP:0001141)1.72924717
149Progressive cerebellar ataxia (HP:0002073)1.71822943
150Horseshoe kidney (HP:0000085)1.69717567

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.96038101
2CASK3.85386806
3STK163.01945466
4ZAK2.92758512
5WNK32.55482200
6SRPK12.52164727
7BRD42.44368370
8TNIK2.37169084
9WNK42.31743920
10CCNB12.25293445
11CDC72.24107150
12EIF2AK12.05144043
13BMPR21.96371561
14MKNK21.94685642
15TXK1.89163354
16AKT31.82157408
17TLK11.76955876
18MAP4K21.76240763
19MKNK11.72474652
20STK38L1.70061504
21EIF2AK21.69716196
22NEK61.67495839
23TAOK31.67474352
24PLK41.66992186
25VRK11.66124444
26STK391.60691907
27BMPR1B1.54824527
28ADRBK21.47519735
29INSRR1.46753625
30MAP2K71.45169007
31FLT31.42694020
32MAPK131.41011086
33TTK1.39551131
34NTRK31.38133747
35MAP3K141.36958661
36BUB11.35323876
37PASK1.34763597
38TGFBR11.32244745
39CDK81.25049546
40ATR1.24243241
41IRAK41.21225263
42IRAK31.18273154
43SIK31.16301671
44CDK31.16099834
45GRK71.14615533
46CLK11.14553285
47MAP3K41.14430304
48YES11.13731375
49TSSK61.13060586
50OBSCN1.11495572
51TAF11.10410959
52SGK21.07372647
53VRK21.05673004
54PINK11.04915686
55WEE11.02958894
56NEK21.02777308
57FGFR21.01725702
58GRK10.99245986
59ERBB30.96780071
60TNK20.96676441
61EIF2AK30.96498433
62PNCK0.94717366
63PLK30.93636010
64PLK20.92805648
65AURKA0.92691538
66PLK10.91705625
67TRIM280.91114444
68CHEK20.89161814
69PRPF4B0.88937966
70BRAF0.87389888
71CDC42BPA0.86746379
72PHKG20.85371505
73PHKG10.85371505
74NME10.83361567
75PRKCI0.83198669
76TEC0.82864538
77DYRK1A0.80757792
78MAP3K120.80164429
79PIK3CA0.77776774
80IRAK20.77252689
81EPHA30.76019739
82MAPKAPK30.75627176
83NEK10.75579170
84MARK10.70937291
85DAPK20.70749695
86CDK70.70656213
87TRPM70.70570129
88DYRK20.68398819
89SGK2230.68021750
90SGK4940.68021750
91BRSK10.63810360
92CAMK1G0.62382071
93PRKCQ0.62019515
94ADRBK10.60946803
95STK30.60772315
96CDK190.59504177
97PRKCE0.58722867
98BCR0.58147035
99PTK2B0.57937754
100MAPKAPK50.56782869
101AURKB0.54497910
102KIT0.53990963
103MST40.53989883
104ATM0.53850854
105NUAK10.52255068
106WNK10.52123591
107MAP2K60.51374810
108MELK0.50187947
109RPS6KA50.49977688
110LYN0.49883978
111PAK30.49693299
112BTK0.48421883
113BRSK20.47168804
114STK110.46688262
115CSF1R0.46348486
116MARK30.46069555
117BCKDK0.45942790
118ITK0.45388470
119CSNK1D0.44778926
120MUSK0.44600100
121PRKAA20.43618758
122ACVR1B0.43453624
123TIE10.43434079
124CSNK1G10.43217761
125SIK20.42823342
126CSNK2A10.42632309
127CHEK10.42306520
128DAPK10.42133751
129PBK0.41721969
130PRKAA10.41545921
131RPS6KB10.41531953
132IKBKB0.41467488
133RPS6KB20.41212739
134MAPK70.39139935
135OXSR10.39128358
136DYRK30.38792130
137CDK10.38144333
138NLK0.37999182
139PRKCZ0.37494118
140MINK10.35685822
141CAMKK20.35384591
142CAMK1D0.35376918
143PIM10.34917931
144RPS6KA60.34904062
145PRKCG0.34734547
146CAMK10.34431514
147CSNK1A10.33845786
148MAP3K70.32708310
149STK40.31775503
150EPHA20.30558144
151CSNK2A20.29048335
152MAPK150.27638445

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.70168399
2DNA replication_Homo sapiens_hsa030303.59284161
3Homologous recombination_Homo sapiens_hsa034403.37918144
4Fanconi anemia pathway_Homo sapiens_hsa034603.19318658
5RNA polymerase_Homo sapiens_hsa030202.75129342
6Non-homologous end-joining_Homo sapiens_hsa034502.73049739
7Nucleotide excision repair_Homo sapiens_hsa034202.64697901
8Base excision repair_Homo sapiens_hsa034102.47507483
9Basal transcription factors_Homo sapiens_hsa030222.30022984
10Selenocompound metabolism_Homo sapiens_hsa004502.23687514
11Protein export_Homo sapiens_hsa030602.21017476
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.16494244
13Spliceosome_Homo sapiens_hsa030402.13130143
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.96092838
15Butanoate metabolism_Homo sapiens_hsa006501.95086926
16Nitrogen metabolism_Homo sapiens_hsa009101.91541764
17Cell cycle_Homo sapiens_hsa041101.89217844
18Pyrimidine metabolism_Homo sapiens_hsa002401.89091466
19Proteasome_Homo sapiens_hsa030501.70603133
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.61609189
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.61476688
22RNA degradation_Homo sapiens_hsa030181.61223951
23Nicotine addiction_Homo sapiens_hsa050331.59184354
24Tryptophan metabolism_Homo sapiens_hsa003801.54056380
25Purine metabolism_Homo sapiens_hsa002301.47877697
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.47866527
27SNARE interactions in vesicular transport_Homo sapiens_hsa041301.46974278
28One carbon pool by folate_Homo sapiens_hsa006701.41090203
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.34836304
30Phototransduction_Homo sapiens_hsa047441.34760999
31Ribosome_Homo sapiens_hsa030101.34570528
32Lysine degradation_Homo sapiens_hsa003101.34304836
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.33857328
34Propanoate metabolism_Homo sapiens_hsa006401.33325001
35Taste transduction_Homo sapiens_hsa047421.30486931
36Caffeine metabolism_Homo sapiens_hsa002321.29704690
37RNA transport_Homo sapiens_hsa030131.24560758
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.24118532
39Oxidative phosphorylation_Homo sapiens_hsa001901.23848028
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.22840662
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.19554257
42mRNA surveillance pathway_Homo sapiens_hsa030151.13670545
43ABC transporters_Homo sapiens_hsa020101.08695051
44Huntingtons disease_Homo sapiens_hsa050161.06193410
45Sulfur relay system_Homo sapiens_hsa041221.03856348
46Regulation of autophagy_Homo sapiens_hsa041401.03691174
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.01726847
48Circadian rhythm_Homo sapiens_hsa047100.96492342
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.95594504
50Arachidonic acid metabolism_Homo sapiens_hsa005900.94774193
51Morphine addiction_Homo sapiens_hsa050320.93649706
52Other glycan degradation_Homo sapiens_hsa005110.91901272
53Vitamin B6 metabolism_Homo sapiens_hsa007500.91602281
54Serotonergic synapse_Homo sapiens_hsa047260.90243927
55Glycerolipid metabolism_Homo sapiens_hsa005610.89523633
56Cardiac muscle contraction_Homo sapiens_hsa042600.85708490
57Maturity onset diabetes of the young_Homo sapiens_hsa049500.85603354
58Collecting duct acid secretion_Homo sapiens_hsa049660.84749903
59Parkinsons disease_Homo sapiens_hsa050120.83825027
60p53 signaling pathway_Homo sapiens_hsa041150.83546844
61Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.80901352
62Peroxisome_Homo sapiens_hsa041460.79690328
63Vitamin digestion and absorption_Homo sapiens_hsa049770.75404535
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72196249
65Ovarian steroidogenesis_Homo sapiens_hsa049130.71323350
66Chemical carcinogenesis_Homo sapiens_hsa052040.71101686
67Primary bile acid biosynthesis_Homo sapiens_hsa001200.70463299
68Primary immunodeficiency_Homo sapiens_hsa053400.67865499
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67601168
70Sphingolipid metabolism_Homo sapiens_hsa006000.67287902
71Vibrio cholerae infection_Homo sapiens_hsa051100.66081516
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65514892
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65330757
74Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.65060301
75Linoleic acid metabolism_Homo sapiens_hsa005910.64397481
76Cysteine and methionine metabolism_Homo sapiens_hsa002700.63173122
77Inositol phosphate metabolism_Homo sapiens_hsa005620.62456637
78Alzheimers disease_Homo sapiens_hsa050100.62345897
79Type I diabetes mellitus_Homo sapiens_hsa049400.61650674
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.60807704
81Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.60521802
82Systemic lupus erythematosus_Homo sapiens_hsa053220.60185607
83Epstein-Barr virus infection_Homo sapiens_hsa051690.59045158
84Circadian entrainment_Homo sapiens_hsa047130.58097824
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57063422
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56895646
87Retinol metabolism_Homo sapiens_hsa008300.56836543
88N-Glycan biosynthesis_Homo sapiens_hsa005100.56362110
89Autoimmune thyroid disease_Homo sapiens_hsa053200.55835542
90Cyanoamino acid metabolism_Homo sapiens_hsa004600.54886124
91Olfactory transduction_Homo sapiens_hsa047400.53883137
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53747799
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53085724
94Hematopoietic cell lineage_Homo sapiens_hsa046400.52951466
95Intestinal immune network for IgA production_Homo sapiens_hsa046720.52646900
96Synaptic vesicle cycle_Homo sapiens_hsa047210.52496235
97Insulin secretion_Homo sapiens_hsa049110.52468200
98Alcoholism_Homo sapiens_hsa050340.51808789
99Herpes simplex infection_Homo sapiens_hsa051680.50521962
100alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.50060505
101Long-term depression_Homo sapiens_hsa047300.49330474
102Fat digestion and absorption_Homo sapiens_hsa049750.48557260
103Fatty acid degradation_Homo sapiens_hsa000710.48323707
104Ether lipid metabolism_Homo sapiens_hsa005650.47272530
105Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45819513
106Fatty acid metabolism_Homo sapiens_hsa012120.43284913
107Glutamatergic synapse_Homo sapiens_hsa047240.42073578
108Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41701720
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.41676400
110Basal cell carcinoma_Homo sapiens_hsa052170.40876875
111Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40800772
112Allograft rejection_Homo sapiens_hsa053300.40356672
113NF-kappa B signaling pathway_Homo sapiens_hsa040640.39291158
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39072605
115Phagosome_Homo sapiens_hsa041450.38094321
116Amphetamine addiction_Homo sapiens_hsa050310.37644935
117beta-Alanine metabolism_Homo sapiens_hsa004100.37056030
118Hedgehog signaling pathway_Homo sapiens_hsa043400.36864187
119Calcium signaling pathway_Homo sapiens_hsa040200.36710440
120Oocyte meiosis_Homo sapiens_hsa041140.36634412
121Fatty acid biosynthesis_Homo sapiens_hsa000610.36102436
122Rheumatoid arthritis_Homo sapiens_hsa053230.34349460
123Steroid biosynthesis_Homo sapiens_hsa001000.33934653
124Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33439145
125Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.33214856
126Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.31665017
127Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.28856404
128Metabolic pathways_Homo sapiens_hsa011000.28381364
129GABAergic synapse_Homo sapiens_hsa047270.28268226
130Melanoma_Homo sapiens_hsa052180.25557109
131Measles_Homo sapiens_hsa051620.25071080
132Wnt signaling pathway_Homo sapiens_hsa043100.24239166
133Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.24024943
134HTLV-I infection_Homo sapiens_hsa051660.21807314
135Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.21576560
136Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.21427310
137Graft-versus-host disease_Homo sapiens_hsa053320.21390609
138Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.20664901
139Dopaminergic synapse_Homo sapiens_hsa047280.20468907
140Viral carcinogenesis_Homo sapiens_hsa052030.20047310
141Cocaine addiction_Homo sapiens_hsa050300.18783835

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