SNAI1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo. At least two variants of a similar processed pseudogene have been found on chromosome 2. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* regulation of vitamin D biosynthetic process (GO:0060556)6.55991230
2cell migration involved in heart development (GO:0060973)4.91829288
3regulation of cytokine secretion involved in immune response (GO:0002739)4.89486675
4protein heterotrimerization (GO:0070208)4.87445664
5* regulation of vitamin metabolic process (GO:0030656)4.80775949
6positive regulation of chemokine biosynthetic process (GO:0045080)4.74088604
7regulation of chemokine biosynthetic process (GO:0045073)4.50742926
8regulation of membrane protein ectodomain proteolysis (GO:0051043)4.44892102
9positive regulation of heat generation (GO:0031652)4.44592417
10cell migration involved in gastrulation (GO:0042074)4.30032319
11collagen fibril organization (GO:0030199)4.29147149
12positive regulation of p38MAPK cascade (GO:1900745)4.28288701
13chondrocyte proliferation (GO:0035988)4.23268452
14response to peptidoglycan (GO:0032494)4.15975385
15positive regulation of membrane protein ectodomain proteolysis (GO:0051044)4.15054598
16regulation of T-helper 1 cell differentiation (GO:0045625)4.13421249
17regulation of fever generation (GO:0031620)4.10439999
18branching involved in labyrinthine layer morphogenesis (GO:0060670)4.05513600
19bone trabecula formation (GO:0060346)4.05424707
20regulation of chronic inflammatory response (GO:0002676)3.99700341
21lipopolysaccharide-mediated signaling pathway (GO:0031663)3.91740148
22paraxial mesoderm development (GO:0048339)3.91720755
23regulation of mesoderm development (GO:2000380)3.87243123
24positive regulation of nitric oxide biosynthetic process (GO:0045429)3.73281859
25negative regulation of interleukin-12 production (GO:0032695)3.72080878
26activation of MAPKKK activity (GO:0000185)3.69999213
27regulation of nitric oxide biosynthetic process (GO:0045428)3.69739157
28outer ear morphogenesis (GO:0042473)3.67845661
29decidualization (GO:0046697)3.67472311
30endodermal cell differentiation (GO:0035987)3.64197014
31negative regulation of nitric oxide biosynthetic process (GO:0045019)3.63561488
32wound healing, spreading of epidermal cells (GO:0035313)3.58759126
33negative regulation of cytokine production involved in immune response (GO:0002719)3.50690200
34regulation of podosome assembly (GO:0071801)3.46848817
35regulation of heterotypic cell-cell adhesion (GO:0034114)3.46759700
36sequestering of extracellular ligand from receptor (GO:0035581)3.43619854
37epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.42765016
38regulation of T-helper 2 cell differentiation (GO:0045628)3.42176799
39negative regulation of cell fate specification (GO:0009996)3.41279589
40regulation of gastrulation (GO:0010470)3.41178519
41skin morphogenesis (GO:0043589)3.41147954
42virion attachment to host cell (GO:0019062)3.31902580
43adhesion of symbiont to host cell (GO:0044650)3.31902580
44positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.26686142
45anterior/posterior axis specification, embryo (GO:0008595)3.22461342
46response to laminar fluid shear stress (GO:0034616)3.19916601
47peptidyl-proline hydroxylation (GO:0019511)3.18931432
48signal transduction involved in regulation of gene expression (GO:0023019)3.17051944
49regulation of heat generation (GO:0031650)3.16847426
50mesenchymal-epithelial cell signaling (GO:0060638)3.13407333
51regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.12764168
52organ induction (GO:0001759)3.08990493
53positive regulation of astrocyte differentiation (GO:0048711)3.08417948
54regulation of mononuclear cell migration (GO:0071675)3.07271300
55middle ear morphogenesis (GO:0042474)3.05842073
56regulation of interferon-alpha production (GO:0032647)3.04347241
57regulation of retinoic acid receptor signaling pathway (GO:0048385)3.03283884
58heart field specification (GO:0003128)3.02736728
59secondary heart field specification (GO:0003139)3.02736728
60negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.02391672
61formation of translation preinitiation complex (GO:0001731)3.01966177
62regulation of apoptotic process involved in morphogenesis (GO:1902337)2.99522452
63wound healing, spreading of cells (GO:0044319)2.99385863
64positive regulation of NF-kappaB import into nucleus (GO:0042346)2.98931043
65positive regulation of interleukin-6 production (GO:0032755)2.98387031
66adhesion of symbiont to host (GO:0044406)2.96281424
67mitotic metaphase plate congression (GO:0007080)2.95220015
68positive regulation of gastrulation (GO:2000543)2.94218426
69cellular response to lipopolysaccharide (GO:0071222)2.92660876
70regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.92604495
71regulation of spindle organization (GO:0090224)2.92466907
72cell adhesion mediated by integrin (GO:0033627)2.90820395
73regulation of immunoglobulin secretion (GO:0051023)2.90772811
74protein hydroxylation (GO:0018126)2.90736507
75planar cell polarity pathway involved in neural tube closure (GO:0090179)2.90015434
76polarized epithelial cell differentiation (GO:0030859)2.89638438
77notochord development (GO:0030903)2.88148360
78cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.88118316
79positive regulation of type 2 immune response (GO:0002830)2.88012155
80negative regulation of chondrocyte differentiation (GO:0032331)2.87927113
81regulation of p38MAPK cascade (GO:1900744)2.86433271
82positive regulation of fat cell differentiation (GO:0045600)2.86202916
83* negative regulation of embryonic development (GO:0045992)2.85938409
84T-helper 1 type immune response (GO:0042088)2.84813779
85DNA deamination (GO:0045006)2.84622656
86protein localization to kinetochore (GO:0034501)2.84129484
87endothelium development (GO:0003158)2.83802019
88extracellular fibril organization (GO:0043206)2.83586115
89* positive regulation of epithelial to mesenchymal transition (GO:0010718)2.81541825
90regulation of integrin-mediated signaling pathway (GO:2001044)2.81147022
91negative regulation of lipid storage (GO:0010888)2.80060430
92G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.78907904
93regulation of interleukin-8 biosynthetic process (GO:0045414)2.78639334
94positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.78197337
95hyaluronan catabolic process (GO:0030214)2.77288044
96regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.76150089
97germinal center formation (GO:0002467)2.75295908
98fibril organization (GO:0097435)2.75166340
99cellular response to molecule of bacterial origin (GO:0071219)2.74590339
100hippo signaling (GO:0035329)2.72351618
101ribosome assembly (GO:0042255)2.72274911
102regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.71887421
103otic vesicle formation (GO:0030916)2.71439342
104regulation of mitotic spindle organization (GO:0060236)2.71269947
105cellular response to arsenic-containing substance (GO:0071243)2.70759001
106protein retention in ER lumen (GO:0006621)2.69596615
107gastrulation (GO:0007369)2.69557146
108neural crest cell development (GO:0014032)2.67968921
109negative regulation of catenin import into nucleus (GO:0035414)2.66774833
110regulation of NF-kappaB import into nucleus (GO:0042345)2.66524666
111lung morphogenesis (GO:0060425)2.65348546
112mitotic nuclear envelope disassembly (GO:0007077)2.65264332
113negative regulation of tumor necrosis factor production (GO:0032720)2.65002699
114mRNA transcription (GO:0009299)2.64802310
115negative regulation of production of molecular mediator of immune response (GO:0002701)2.64757307
116metanephric mesenchyme development (GO:0072075)2.64380935
117collagen metabolic process (GO:0032963)2.63113466
118positive regulation of endothelial cell apoptotic process (GO:2000353)2.62930009
119* trophoblast giant cell differentiation (GO:0060707)2.62301469
120myeloid dendritic cell differentiation (GO:0043011)2.62263424
121negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.61584525
122vagina development (GO:0060068)2.61550929
123monocyte chemotaxis (GO:0002548)2.60878135
124low-density lipoprotein particle clearance (GO:0034383)2.60692258
125endothelial cell morphogenesis (GO:0001886)2.60220497
126embryo implantation (GO:0007566)2.60106622
127viral transcription (GO:0019083)2.59368789
128negative regulation of cartilage development (GO:0061037)2.59223127
129NIK/NF-kappaB signaling (GO:0038061)2.59220993
130regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.58096545
131regulation of vascular endothelial growth factor production (GO:0010574)2.57816702
132maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.57609414
133positive regulation of acute inflammatory response (GO:0002675)2.56438911
134establishment of apical/basal cell polarity (GO:0035089)2.56021990
135basement membrane organization (GO:0071711)2.55909118
136proline biosynthetic process (GO:0006561)2.55661173
137negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.55648790
138positive regulation of T-helper cell differentiation (GO:0045624)2.54970488
139regulation of type I interferon-mediated signaling pathway (GO:0060338)2.54145897
140primitive streak formation (GO:0090009)2.54116696
141embryonic cranial skeleton morphogenesis (GO:0048701)2.54055132
142translational termination (GO:0006415)2.53649687
143craniofacial suture morphogenesis (GO:0097094)2.52921642
144positive regulation of chemokine production (GO:0032722)2.52730643
145chronic inflammatory response (GO:0002544)2.51965321
146ribosomal small subunit biogenesis (GO:0042274)2.51320213
147cardiac epithelial to mesenchymal transition (GO:0060317)2.49872576
148regulation of histone phosphorylation (GO:0033127)2.49774489
149membrane disassembly (GO:0030397)2.49668029
150nuclear envelope disassembly (GO:0051081)2.49668029
151response to protozoan (GO:0001562)2.49007502
152translational initiation (GO:0006413)2.48913545
153kidney mesenchyme development (GO:0072074)2.48748584
154response to vitamin D (GO:0033280)2.48309723
155regulation of interleukin-6 production (GO:0032675)2.47392984
156ovulation (GO:0030728)2.47328154
157positive regulation of transcription factor import into nucleus (GO:0042993)2.46742271
158positive regulation of lymphocyte apoptotic process (GO:0070230)2.46600656
159oligosaccharide catabolic process (GO:0009313)2.46464316
160regulation of G0 to G1 transition (GO:0070316)2.46391958
161aorta morphogenesis (GO:0035909)2.45895530
162regulation of cell fate specification (GO:0042659)2.45871157
163response to progesterone (GO:0032570)2.45619837
164mesoderm development (GO:0007498)2.44920040
165cell proliferation involved in metanephros development (GO:0072203)2.43925652
166mRNA transcription from RNA polymerase II promoter (GO:0042789)2.43911728
167ribosome biogenesis (GO:0042254)2.43566015
168positive regulation of hair cycle (GO:0042635)2.43416896
169positive regulation of hair follicle development (GO:0051798)2.43416896
170mature B cell differentiation involved in immune response (GO:0002313)2.43251645
171folic acid-containing compound biosynthetic process (GO:0009396)2.43091736
172response to muramyl dipeptide (GO:0032495)2.42713732
173regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.42643104
174nodal signaling pathway (GO:0038092)2.42590546
175regulation of T-helper cell differentiation (GO:0045622)2.42302541
176ventricular cardiac muscle cell development (GO:0055015)2.42125953
177mesenchyme development (GO:0060485)2.42093049
178regulation of early endosome to late endosome transport (GO:2000641)2.41531714
179cyclooxygenase pathway (GO:0019371)2.41365280
180positive regulation vascular endothelial growth factor production (GO:0010575)2.40791717
181regulation of posttranscriptional gene silencing (GO:0060147)2.40570905
182regulation of gene silencing by miRNA (GO:0060964)2.40570905
183regulation of gene silencing by RNA (GO:0060966)2.40570905
184collagen catabolic process (GO:0030574)2.40350449
185dermatan sulfate biosynthetic process (GO:0030208)2.39653400
186embryonic skeletal joint morphogenesis (GO:0060272)2.39251822
187multicellular organismal macromolecule metabolic process (GO:0044259)2.38786110
188cranial suture morphogenesis (GO:0060363)2.37378939
189substrate adhesion-dependent cell spreading (GO:0034446)2.37372466
190regulation of SMAD protein import into nucleus (GO:0060390)2.37255716
191regulation of hippo signaling (GO:0035330)2.35774037
192regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.34984401

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_18555785_ChIP-Seq_MESCs_Mouse3.79315263
2E2F7_22180533_ChIP-Seq_HELA_Human3.53371591
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.41264668
4* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.26825604
5TRIM28_21343339_ChIP-Seq_HEK293_Human3.26787258
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.25410396
7RARG_19884340_ChIP-ChIP_MEFs_Mouse3.08907325
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.04919008
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.80062247
10NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.77433249
11STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.59503926
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.51352515
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.40912613
14PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.40601177
15* NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.37469348
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.35712311
17ESR2_21235772_ChIP-Seq_MCF-7_Human2.33181719
18ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.22129472
19TP63_19390658_ChIP-ChIP_HaCaT_Human2.21402713
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.18592264
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.17538013
22RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.15753647
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.14732297
24* XRN2_22483619_ChIP-Seq_HELA_Human2.05877624
25CREB1_15753290_ChIP-ChIP_HEK293T_Human2.05454895
26ESR1_21235772_ChIP-Seq_MCF-7_Human2.01538082
27TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.00585905
28ETS1_20019798_ChIP-Seq_JURKAT_Human1.98851229
29* ELK3_25401928_ChIP-Seq_HUVEC_Human1.98435486
30NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.94460898
31NELFA_20434984_ChIP-Seq_ESCs_Mouse1.93491725
32AR_21909140_ChIP-Seq_LNCAP_Human1.93463667
33CLOCK_20551151_ChIP-Seq_293T_Human1.92582591
34HIF1A_21447827_ChIP-Seq_MCF-7_Human1.86509261
35MYB_21317192_ChIP-Seq_ERMYB_Mouse1.85272952
36VDR_21846776_ChIP-Seq_THP-1_Human1.82550917
37KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.76357983
38MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.75316358
39ZNF263_19887448_ChIP-Seq_K562_Human1.74202230
40E2F4_17652178_ChIP-ChIP_JURKAT_Human1.72963305
41* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.72562659
42STAT3_1855785_ChIP-Seq_MESCs_Mouse1.71780802
43EST1_17652178_ChIP-ChIP_JURKAT_Human1.70730319
44TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.70358962
45GABP_17652178_ChIP-ChIP_JURKAT_Human1.68931659
46IRF8_21731497_ChIP-ChIP_J774_Mouse1.67829943
47STAT4_19710469_ChIP-ChIP_TH1__Mouse1.67445540
48* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.66804857
49ATF3_27146783_Chip-Seq_COLON_Human1.65666147
50SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.64810407
51NANOG_18555785_ChIP-Seq_MESCs_Mouse1.61952456
52E2F1_18555785_ChIP-Seq_MESCs_Mouse1.60823378
53LXR_22292898_ChIP-Seq_THP-1_Human1.59807226
54ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.58267892
55* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.57783115
56* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.56359563
57* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.53770214
58JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.53714128
59KDM2B_26808549_Chip-Seq_SUP-B15_Human1.53705706
60IRF8_27001747_Chip-Seq_BMDM_Mouse1.50776969
61KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.47929017
62CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.47595730
63DCP1A_22483619_ChIP-Seq_HELA_Human1.44410778
64* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.43401813
65* TTF2_22483619_ChIP-Seq_HELA_Human1.43002557
66THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.42807533
67* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.42180071
68MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.40008522
69VDR_24763502_ChIP-Seq_THP-1_Human1.39923747
70MYC_22102868_ChIP-Seq_BL_Human1.39407024
71SMAD_19615063_ChIP-ChIP_OVARY_Human1.39132618
72PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.38325587
73ZFX_18555785_ChIP-Seq_MESCs_Mouse1.38097977
74ELK1_22589737_ChIP-Seq_MCF10A_Human1.36400534
75BP1_19119308_ChIP-ChIP_Hs578T_Human1.36279649
76SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.36055571
77* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.34624893
78BRD4_27068464_Chip-Seq_AML-cells_Mouse1.34451127
79* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.34252319
80KLF4_18555785_ChIP-Seq_MESCs_Mouse1.33171230
81TP53_22127205_ChIP-Seq_IMR90_Human1.32490393
82* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.32398631
83GABP_19822575_ChIP-Seq_HepG2_Human1.31286777
84TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30075915
85RACK7_27058665_Chip-Seq_MCF-7_Human1.27425352
86* KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.27338291
87* KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.27338291
88* KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.27338291
89* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.27209315
90SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.26788266
91UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.26508557
92KDM2B_26808549_Chip-Seq_DND41_Human1.25134736
93KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.24910954
94Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.24774659
95KDM2B_26808549_Chip-Seq_K562_Human1.23550925
96BRD4_25478319_ChIP-Seq_HGPS_Human1.22833336
97E2F1_21310950_ChIP-Seq_MCF-7_Human1.21803576
98SMC1_22415368_ChIP-Seq_MEFs_Mouse1.21525494
99CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.20254462
100IRF8_22096565_ChIP-ChIP_GC-B_Human1.20142005
101JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19588069
102* TCF7_22412390_ChIP-Seq_EML_Mouse1.18792522
103STAT6_21828071_ChIP-Seq_BEAS2B_Human1.18561238
104NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.18167313
105TP53_20018659_ChIP-ChIP_R1E_Mouse1.17523594
106NANOG_16153702_ChIP-ChIP_HESCs_Human1.17407863
107SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.17223886
108SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.16377291
109SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.16377291
110* NCOR1_26117541_ChIP-Seq_K562_Human1.16143568
111POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.15211443
112GATA2_21666600_ChIP-Seq_HMVEC_Human1.15073244
113UBF1/2_26484160_Chip-Seq_HMECs_Human1.13733539
114* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.13134803
115TFEB_21752829_ChIP-Seq_HELA_Human1.12732977
116* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.12323850
117PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12144858
118JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12103744
119EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.10758463
120P300_27058665_Chip-Seq_ZR-75-30cells_Human1.09787464
121* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.09134149
122NANOG_21062744_ChIP-ChIP_HESCs_Human1.08305192
123SRY_22984422_ChIP-ChIP_TESTIS_Rat1.08188811
124HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.06458393
125POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.05361322
126RBPJ_22232070_ChIP-Seq_NCS_Mouse1.04900249
127KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.03126458
128SMC3_22415368_ChIP-Seq_MEFs_Mouse1.02723598
129HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.02700334
130SALL4_18804426_ChIP-ChIP_XEN_Mouse1.02495582
131CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02460888
132SOX2_18555785_ChIP-Seq_MESCs_Mouse1.02454350
133CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02405681
134PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00849222
135NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.00278729
136NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00210381
137CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.99714488
138STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.99329351
139SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.98972641
140ELK1_19687146_ChIP-ChIP_HELA_Human0.98172195
141WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.98103378
142RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97487439
143EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.96159375
144TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95800200
145* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95548999
146MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.95392728
147VDR_24787735_ChIP-Seq_THP-1_Human0.94144782
148CTCF_27219007_Chip-Seq_ERYTHROID_Human0.91635325
149RUNX1_22412390_ChIP-Seq_EML_Mouse0.90248465
150RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.88112779
151* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.86887406
152TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.86525683

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.79824809
2MP0003303_peritoneal_inflammation5.00280977
3MP0005503_abnormal_tendon_morphology4.17818870
4MP0003705_abnormal_hypodermis_morpholog3.86731084
5MP0010030_abnormal_orbit_morphology3.70433577
6MP0003279_aneurysm3.56539348
7MP0005275_abnormal_skin_tensile3.33206874
8MP0004510_myositis3.16577962
9MP0009840_abnormal_foam_cell2.73315927
10MP0008004_abnormal_stomach_pH2.63908131
11MP0006082_CNS_inflammation2.62541530
12MP0005058_abnormal_lysosome_morphology2.62390825
13MP0002254_reproductive_system_inflammat2.46909715
14MP0005623_abnormal_meninges_morphology2.40436856
15MP0003436_decreased_susceptibility_to2.35009127
16MP0002148_abnormal_hypersensitivity_rea2.33701059
17MP0003724_increased_susceptibility_to2.24364944
18MP0005508_abnormal_skeleton_morphology2.19337197
19MP0004272_abnormal_basement_membrane2.19331928
20MP0006054_spinal_hemorrhage2.16890124
21MP0001958_emphysema2.16793060
22MP0009785_altered_susceptibility_to2.10375830
23MP0003385_abnormal_body_wall2.03979203
24MP0000343_altered_response_to2.03691410
25MP0009764_decreased_sensitivity_to2.03211474
26MP0005023_abnormal_wound_healing1.95110055
27MP0003300_gastrointestinal_ulcer1.90789991
28MP0009384_cardiac_valve_regurgitation1.90122090
29MP0002332_abnormal_exercise_endurance1.89881680
30MP0002932_abnormal_joint_morphology1.88401082
31MP0009250_abnormal_appendicular_skeleto1.84102670
32MP0003566_abnormal_cell_adhesion1.80959388
33MP0001853_heart_inflammation1.80302816
34MP0010368_abnormal_lymphatic_system1.80257020
35MP0005257_abnormal_intraocular_pressure1.80122741
36MP0004957_abnormal_blastocyst_morpholog1.79681930
37MP0003448_altered_tumor_morphology1.76980310
38MP0000049_abnormal_middle_ear1.75952522
39MP0005451_abnormal_body_composition1.75021144
40MP0008932_abnormal_embryonic_tissue1.73123463
41MP0010352_gastrointestinal_tract_polyps1.69836607
42MP0003075_altered_response_to1.69608493
43MP0003119_abnormal_digestive_system1.69398982
44MP0001533_abnormal_skeleton_physiology1.67336040
45MP0009053_abnormal_anal_canal1.67196378
46MP0003453_abnormal_keratinocyte_physiol1.65790307
47MP0004947_skin_inflammation1.59499860
48MP0002249_abnormal_larynx_morphology1.56704574
49MP0003693_abnormal_embryo_hatching1.56258439
50MP0005397_hematopoietic_system_phenotyp1.54335286
51MP0001545_abnormal_hematopoietic_system1.54335286
52MP0003942_abnormal_urinary_system1.51235077
53MP0003937_abnormal_limbs/digits/tail_de1.50680840
54MP0005167_abnormal_blood-brain_barrier1.48583525
55MP0003950_abnormal_plasma_membrane1.46260757
56MP0005000_abnormal_immune_tolerance1.43984168
57MP0001542_abnormal_bone_strength1.43495134
58MP0003283_abnormal_digestive_organ1.42800834
59MP0002282_abnormal_trachea_morphology1.42051162
60MP0003828_pulmonary_edema1.37616589
61MP0000428_abnormal_craniofacial_morphol1.37337359
62MP0000858_altered_metastatic_potential1.37056277
63MP0002998_abnormal_bone_remodeling1.36759299
64MP0002060_abnormal_skin_morphology1.36740768
65MP0002111_abnormal_tail_morphology1.36601702
66MP0002419_abnormal_innate_immunity1.36550095
67MP0008007_abnormal_cellular_replicative1.35789704
68MP0003077_abnormal_cell_cycle1.34945933
69MP0002234_abnormal_pharynx_morphology1.31279684
70MP0000733_abnormal_muscle_development1.30029535
71MP0001243_abnormal_dermal_layer1.28590522
72* MP0003755_abnormal_palate_morphology1.28478770
73MP0000767_abnormal_smooth_muscle1.26282923
74MP0000750_abnormal_muscle_regeneration1.24448136
75MP0003123_paternal_imprinting1.24055286
76* MP0005380_embryogenesis_phenotype1.23848745
77* MP0001672_abnormal_embryogenesis/_devel1.23848745
78* MP0002085_abnormal_embryonic_tissue1.22871701
79MP0003890_abnormal_embryonic-extraembry1.22688906
80* MP0002084_abnormal_developmental_patter1.22253036
81MP0008260_abnormal_autophagy1.22141908
82MP0005165_increased_susceptibility_to1.21859765
83MP0004808_abnormal_hematopoietic_stem1.21312860
84MP0005164_abnormal_response_to1.21113100
85MP0002108_abnormal_muscle_morphology1.18302228
86* MP0003935_abnormal_craniofacial_develop1.18073976
87MP0003111_abnormal_nucleus_morphology1.18065555
88MP0003115_abnormal_respiratory_system1.16193471
89MP0002295_abnormal_pulmonary_circulatio1.15949186
90MP0000432_abnormal_head_morphology1.15728724
91MP0004133_heterotaxia1.15050076
92MP0005076_abnormal_cell_differentiation1.14744930
93MP0004197_abnormal_fetal_growth/weight/1.14743137
94* MP0003091_abnormal_cell_migration1.14663996
95MP0005025_abnormal_response_to1.14180617
96* MP0001730_embryonic_growth_arrest1.13827567
97MP0009333_abnormal_splenocyte_physiolog1.12556704
98MP0005595_abnormal_vascular_smooth1.12107542
99MP0002653_abnormal_ependyma_morphology1.12020982
100MP0000678_abnormal_parathyroid_gland1.11208703
101MP0005387_immune_system_phenotype1.10994874
102MP0001790_abnormal_immune_system1.10994874
103MP0000350_abnormal_cell_proliferation1.10306815
104MP0005390_skeleton_phenotype1.10144241
105* MP0000163_abnormal_cartilage_morphology1.09530504
106* MP0001697_abnormal_embryo_size1.09400544
107* MP0003984_embryonic_growth_retardation1.08458537
108* MP0002088_abnormal_embryonic_growth/wei1.07150477
109MP0000534_abnormal_ureter_morphology1.07042875
110MP0002877_abnormal_melanocyte_morpholog1.03764598
111MP0002177_abnormal_outer_ear1.03532302
112MP0004858_abnormal_nervous_system1.02396947
113MP0001849_ear_inflammation1.01398454
114MP0002925_abnormal_cardiovascular_devel1.01201141
115MP0008469_abnormal_protein_level0.98422272
116MP0000762_abnormal_tongue_morphology0.98037106
117MP0001915_intracranial_hemorrhage0.97390207
118MP0002114_abnormal_axial_skeleton0.97091563
119* MP0002086_abnormal_extraembryonic_tissu0.96815573
120* MP0002116_abnormal_craniofacial_bone0.95356719
121MP0002452_abnormal_antigen_presenting0.94979407
122MP0005367_renal/urinary_system_phenotyp0.93456252
123MP0000516_abnormal_urinary_system0.93456252
124MP0005166_decreased_susceptibility_to0.92914870
125MP0003941_abnormal_skin_development0.92879786
126MP0002933_joint_inflammation0.92525963
127MP0004233_abnormal_muscle_weight0.92411179
128MP0002115_abnormal_skeleton_extremities0.90860423
129MP0001614_abnormal_blood_vessel0.90297218
130MP0005197_abnormal_uvea_morphology0.89752998
131MP0000537_abnormal_urethra_morphology0.89276119
132MP0003186_abnormal_redox_activity0.88742792
133MP0001845_abnormal_inflammatory_respons0.88329494
134MP0002723_abnormal_immune_serum0.87108388
135MP0002113_abnormal_skeleton_development0.85860890
136* MP0002080_prenatal_lethality0.85802571
137MP0001835_abnormal_antigen_presentation0.85577113
138MP0002109_abnormal_limb_morphology0.85366148
139MP0000462_abnormal_digestive_system0.84054251
140MP0002233_abnormal_nose_morphology0.83322536
141MP0002102_abnormal_ear_morphology0.83167829
142MP0000013_abnormal_adipose_tissue0.81497094
143MP0003567_abnormal_fetal_cardiomyocyte0.80286849
144MP0001299_abnormal_eye_distance/0.80218804
145MP0002405_respiratory_system_inflammati0.78867485
146MP0010155_abnormal_intestine_physiology0.78230194
147MP0004134_abnormal_chest_morphology0.76942910
148MP0010307_abnormal_tumor_latency0.76693768
149MP0002896_abnormal_bone_mineralization0.76405042
150MP0001175_abnormal_lung_morphology0.75376939
151MP0001879_abnormal_lymphatic_vessel0.74398798
152MP0003795_abnormal_bone_structure0.73843685
153MP0005375_adipose_tissue_phenotype0.72897436
154MP0010094_abnormal_chromosome_stability0.72476645
155MP0009278_abnormal_bone_marrow0.72392806
156MP0005666_abnormal_adipose_tissue0.71889112
157MP0000249_abnormal_blood_vessel0.71341632
158MP0009763_increased_sensitivity_to0.71313529
159MP0002938_white_spotting0.71108534
160MP0002128_abnormal_blood_circulation0.69317365
161MP0002139_abnormal_hepatobiliary_system0.65073964
162MP0003221_abnormal_cardiomyocyte_apopto0.64936680
163MP0003191_abnormal_cellular_cholesterol0.61476714
164MP0005410_abnormal_fertilization0.59059923

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)8.18239825
2Premature rupture of membranes (HP:0001788)7.55985126
3Peritonitis (HP:0002586)4.69588216
4Abnormality of liposaccharide metabolism (HP:0010968)4.38165551
5Abnormality of glycosphingolipid metabolism (HP:0004343)4.38165551
6Abnormality of glycolipid metabolism (HP:0010969)4.38165551
7Shallow orbits (HP:0000586)4.38060525
8Soft skin (HP:0000977)4.34996171
9Nuclear cataract (HP:0100018)4.17490704
10Ankle contracture (HP:0006466)4.09927286
11Abnormality of dentin (HP:0010299)4.03569327
12Biconcave vertebral bodies (HP:0004586)3.76285382
13Aortic dissection (HP:0002647)3.76250688
14Bladder diverticulum (HP:0000015)3.57675526
15Vertebral compression fractures (HP:0002953)3.50700117
16Genu recurvatum (HP:0002816)3.44351286
17Systemic lupus erythematosus (HP:0002725)3.40646608
18Atrophic scars (HP:0001075)3.33909522
19Neonatal short-limb short stature (HP:0008921)3.30193478
20Spinal rigidity (HP:0003306)3.26732707
21Dilatation of the ascending aorta (HP:0005111)3.24221253
22Cerebral aneurysm (HP:0004944)3.23380301
23Vacuolated lymphocytes (HP:0001922)3.17717421
24Blue sclerae (HP:0000592)3.16019334
25Wormian bones (HP:0002645)3.15214132
26Dysostosis multiplex (HP:0000943)3.12537744
27Rib fusion (HP:0000902)3.09823084
28Aortic aneurysm (HP:0004942)3.08941709
29Axonal loss (HP:0003447)3.05143460
30Fragile skin (HP:0001030)3.01245650
31Orchitis (HP:0100796)2.95744565
32Cervical subluxation (HP:0003308)2.90942894
33Wrist flexion contracture (HP:0001239)2.89256598
34Type 1 muscle fiber predominance (HP:0003803)2.77163541
35Loss of speech (HP:0002371)2.76741806
36Myocardial infarction (HP:0001658)2.76084250
37Optic neuritis (HP:0100653)2.69650775
38Retrobulbar optic neuritis (HP:0100654)2.69650775
39Broad metatarsal (HP:0001783)2.69469351
40Follicular hyperkeratosis (HP:0007502)2.69443928
41Breech presentation (HP:0001623)2.69107384
42Spondylolisthesis (HP:0003302)2.68965616
43Increased connective tissue (HP:0009025)2.68471770
44Abnormal delivery (HP:0001787)2.63053156
45Bowel diverticulosis (HP:0005222)2.61429922
46Abnormality of macrophages (HP:0004311)2.53609729
47Hyperextensible skin (HP:0000974)2.47462938
48Hematochezia (HP:0002573)2.46839743
49Selective tooth agenesis (HP:0001592)2.41655234
50Abnormality of the acetabulum (HP:0003170)2.38480556
51Mitral valve prolapse (HP:0001634)2.38432636
52Elbow flexion contracture (HP:0002987)2.37319969
53Trismus (HP:0000211)2.35699181
54Calcaneovalgus deformity (HP:0001848)2.35186298
55Abnormality of mucopolysaccharide metabolism (HP:0011020)2.34590237
56Abnormality of polysaccharide metabolism (HP:0011012)2.34590237
57Abnormality of glycosaminoglycan metabolism (HP:0004371)2.34590237
58Increased cerebral lipofuscin (HP:0011813)2.34006856
59Protruding ear (HP:0000411)2.29788856
60Back pain (HP:0003418)2.29171175
61Achilles tendon contracture (HP:0001771)2.26867472
62Deviation of the hallux (HP:0010051)2.25914525
63Thin bony cortex (HP:0002753)2.24986161
64Mesomelia (HP:0003027)2.24400613
65Abnormality of the calcaneus (HP:0008364)2.22273816
66Mucopolysacchariduria (HP:0008155)2.21098507
67Urinary glycosaminoglycan excretion (HP:0003541)2.21098507
68Nonimmune hydrops fetalis (HP:0001790)2.20521595
69Deformed tarsal bones (HP:0008119)2.19763195
70Polycythemia (HP:0001901)2.19218933
71Abnormality of the peritoneum (HP:0002585)2.18286211
72Renal duplication (HP:0000075)2.17350619
73Esophageal varix (HP:0002040)2.16990005
74Slender build (HP:0001533)2.13904262
75Ulnar bowing (HP:0003031)2.12288507
76Hallux valgus (HP:0001822)2.11981589
77Coronal craniosynostosis (HP:0004440)2.11005317
78Broad long bones (HP:0005622)2.10590736
79Increased serum ferritin (HP:0003281)2.09326178
80Myositis (HP:0100614)2.08964743
81Autoimmune thrombocytopenia (HP:0001973)2.07519435
82Wide anterior fontanel (HP:0000260)2.07437018
83Vascular tortuosity (HP:0004948)2.07011807
84Disproportionate tall stature (HP:0001519)2.06322489
85Slender long bone (HP:0003100)2.05986896
86Broad toe (HP:0001837)2.04966805
87Coxa vara (HP:0002812)2.04901372
88Amyloidosis (HP:0011034)2.01303931
89Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.00428584
90Short 4th metacarpal (HP:0010044)2.00428584
91Overgrowth (HP:0001548)1.98345424
92Abnormality of the umbilical cord (HP:0010881)1.98246903
93Abnormality of the Achilles tendon (HP:0005109)1.97245865
94Camptodactyly of toe (HP:0001836)1.96590193
95Sparse lateral eyebrow (HP:0005338)1.96527653
96Mildly elevated creatine phosphokinase (HP:0008180)1.96030361
97Joint laxity (HP:0001388)1.95844889
98Hyperparathyroidism (HP:0000843)1.95420137
99Short nail (HP:0001799)1.95142383
100Abnormal umbilical cord blood vessels (HP:0011403)1.95069456
101Single umbilical artery (HP:0001195)1.95069456
102Abnormality of the fetal cardiovascular system (HP:0010948)1.95069456
103Generalized amyotrophy (HP:0003700)1.94029158
104Shawl scrotum (HP:0000049)1.93666452
105Aplasia/hypoplasia of the humerus (HP:0006507)1.93320207
106Interstitial pulmonary disease (HP:0006530)1.93218219
107Short 5th finger (HP:0009237)1.93118731
108Glomerulonephritis (HP:0000099)1.89230191
109Mild short stature (HP:0003502)1.86784129
110Segmental peripheral demyelination/remyelination (HP:0003481)1.86657118
111Fused cervical vertebrae (HP:0002949)1.86653088
112Aneurysm (HP:0002617)1.85537865
113Breast hypoplasia (HP:0003187)1.83935619
114Abnormality of the vasculature of the conjunctiva (HP:0008054)1.83295018
115Delayed cranial suture closure (HP:0000270)1.83044758
116Broad hallux (HP:0010055)1.80586321
117Neoplasm of head and neck (HP:0012288)1.80307941
118Esophageal neoplasm (HP:0100751)1.80307941
119Increased variability in muscle fiber diameter (HP:0003557)1.79769214
120Abnormality of complement system (HP:0005339)1.79239519
121Short humerus (HP:0005792)1.77776449
122Infantile muscular hypotonia (HP:0008947)1.77572473
123Joint stiffness (HP:0001387)1.77379050
124Abnormality of the distal phalanges of the toes (HP:0010182)1.76964502
125Abnormality of the phalanges of the hallux (HP:0010057)1.76692795
126Short middle phalanx of the 5th finger (HP:0004220)1.76010267
127Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.75425863
128Spinal cord lesions (HP:0100561)1.74746909
129Syringomyelia (HP:0003396)1.74746909
130Keratoconjunctivitis sicca (HP:0001097)1.74322587
131Congenital glaucoma (HP:0001087)1.73549775
132Hypertensive crisis (HP:0100735)1.73378558
133Abnormality of the costochondral junction (HP:0000919)1.73208010
134Inguinal hernia (HP:0000023)1.73064512
135Knee flexion contracture (HP:0006380)1.72036187
136Broad phalanx (HP:0006009)1.71295817
137Pulmonary artery stenosis (HP:0004415)1.70400247
138Parakeratosis (HP:0001036)1.70367230
139Round ear (HP:0100830)1.70280483
140Difficulty climbing stairs (HP:0003551)1.69493819
141Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.69338359
142Femoral bowing (HP:0002980)1.69292762
143Broad thumb (HP:0011304)1.67984969
144Arterial tortuosity (HP:0005116)1.67916176
145Thoracolumbar scoliosis (HP:0002944)1.67683364
146Ectopia lentis (HP:0001083)1.67453418
147Vertebral fusion (HP:0002948)1.67186229
148Patellar aplasia (HP:0006443)1.67126200
149Stomatitis (HP:0010280)1.66710337
150Nausea (HP:0002018)1.66568663
151Aseptic necrosis (HP:0010885)1.66507817
152Rough bone trabeculation (HP:0100670)1.66496990
153Disinhibition (HP:0000734)1.65359336
154Abnormality of skeletal muscle fiber size (HP:0012084)1.65302463
155Congenital hip dislocation (HP:0001374)1.64955319
156Prolonged neonatal jaundice (HP:0006579)1.63888310

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK36.37389050
2DDR23.94888250
3ERN13.48343676
4TESK23.04022895
5TRIB32.97116852
6BUB12.85877085
7PDGFRA2.50563655
8LATS12.39617028
9NME22.38853572
10RPS6KA42.37117982
11PRPF4B2.32979412
12PIM22.25942200
13TGFBR22.21729205
14* LATS22.14229500
15TIE12.12527886
16MAP3K142.10601192
17TESK11.99976776
18TTN1.84029412
19GRK71.81259270
20TBK11.80436774
21PAK21.78411546
22EPHB21.74430927
23STK38L1.72582616
24BMX1.67025669
25MOS1.66952762
26MAP3K111.64019415
27WEE11.62752658
28MATK1.61980605
29CLK11.61619336
30KDR1.60975488
31PAK41.58082436
32LIMK11.57238000
33CDK71.49582587
34PDK21.47379652
35NEK21.47298221
36CDC42BPA1.43691358
37TGFBR11.43102134
38IRAK11.42532255
39IKBKB1.39124810
40PTK21.36768293
41MAP3K101.34616965
42EIF2AK11.34167936
43CDC71.30883401
44MAP3K81.29161338
45PLK11.28556833
46TLK11.27473432
47CDK121.20505996
48BMPR21.19920229
49TTK1.15133274
50TAOK21.13824840
51STK31.13783492
52SIK11.08969483
53TAOK11.07038612
54* PAK11.06567844
55IRAK41.06379162
56MKNK11.05506398
57PLK41.04655793
58CHUK1.03588988
59MTOR1.00653155
60TYK20.99894761
61PKN20.98953668
62IRAK20.96824224
63CDK80.95435329
64TRPM70.93808371
65EPHA20.93765315
66STK100.92987391
67JAK30.92915880
68AURKB0.91702511
69AURKA0.91374548
70MAP3K30.91220572
71DYRK30.90119220
72MAP3K10.89582709
73ABL20.89578368
74FGFR10.88645625
75PTK2B0.88594262
76PRKD20.86612753
77BRSK20.86165394
78ICK0.86152099
79ILK0.84665741
80LRRK20.83206202
81IKBKE0.79947631
82BRAF0.78072668
83BLK0.77863335
84MELK0.77540297
85MAP3K130.77502750
86CHEK20.75124573
87PLK30.74199126
88DYRK20.72242432
89EEF2K0.72164252
90MAP2K30.68307733
91RIPK10.66868329
92CDK60.66607335
93FER0.66388420
94NEK10.65691502
95FGR0.65511249
96AKT30.62920283
97PAK60.62611593
98PAK30.62487294
99PTK60.62453096
100MYLK0.61785478
101KIT0.60130221
102PBK0.60046626
103ZAP700.59323999
104CHEK10.58491765
105EPHB10.57839792
106ERBB40.57746516
107GSK3A0.57097462
108ARAF0.57068792
109CDK90.56831919
110SMG10.56706901
111CDK40.56475991
112RPS6KC10.56046134
113RPS6KL10.56046134
114PRKD30.55525828
115DMPK0.54971518
116CSK0.53981056
117MET0.53772994
118MKNK20.53091247
119MAP3K50.52885267
120TSSK60.52537707
121INSRR0.52320069
122PIM10.51626465
123PASK0.50722818
124TYRO30.50447910
125ROCK10.49270663
126BRSK10.48757726
127ALK0.48357425
128MAPK70.47435654
129PDGFRB0.44544869
130MAP2K10.43652409
131CDK11A0.43557796
132CDK150.43419053
133CDK140.42727470
134ERBB30.42533568
135CDK20.42464012
136RPS6KB20.41713042
137EPHA30.40360442
138RPS6KA60.40277445
139RAF10.39794556
140MAPKAPK20.38780203
141PIK3CG0.38557528
142MAPK40.38525597
143DAPK30.38323797
144PRKCI0.38146949
145STK160.36265094
146STK40.35926525
147BRD40.35869908
148MARK30.33774888
149NTRK10.31029188
150FLT30.29242776
151RPS6KA20.29070889
152SIK30.28931354
153MAPK10.27066671
154INSR0.24519197

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030102.87923985
2Other glycan degradation_Homo sapiens_hsa005112.81815787
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.74853020
4Toll-like receptor signaling pathway_Homo sapiens_hsa046202.64444595
5RNA transport_Homo sapiens_hsa030132.62030222
6RNA polymerase_Homo sapiens_hsa030202.51978032
7ECM-receptor interaction_Homo sapiens_hsa045122.42154461
8Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.41072654
9Pertussis_Homo sapiens_hsa051332.39108719
10p53 signaling pathway_Homo sapiens_hsa041152.37111593
11Cell cycle_Homo sapiens_hsa041102.36702370
12NF-kappa B signaling pathway_Homo sapiens_hsa040642.36147439
13Rheumatoid arthritis_Homo sapiens_hsa053232.35133513
14Spliceosome_Homo sapiens_hsa030402.28096511
15DNA replication_Homo sapiens_hsa030302.21536317
16NOD-like receptor signaling pathway_Homo sapiens_hsa046212.18318788
17Prion diseases_Homo sapiens_hsa050202.15637331
18Hippo signaling pathway_Homo sapiens_hsa043902.08074208
19Osteoclast differentiation_Homo sapiens_hsa043802.05912315
20African trypanosomiasis_Homo sapiens_hsa051432.05025745
21TGF-beta signaling pathway_Homo sapiens_hsa043502.04114281
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.03770919
23One carbon pool by folate_Homo sapiens_hsa006702.03720925
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.02483969
25Glycosaminoglycan degradation_Homo sapiens_hsa005312.01425824
26Basal cell carcinoma_Homo sapiens_hsa052171.98133863
27Bladder cancer_Homo sapiens_hsa052191.94092677
28Base excision repair_Homo sapiens_hsa034101.90289697
29Proteasome_Homo sapiens_hsa030501.89589063
30Focal adhesion_Homo sapiens_hsa045101.88026211
31Hedgehog signaling pathway_Homo sapiens_hsa043401.83486298
32Mismatch repair_Homo sapiens_hsa034301.80145258
33Salmonella infection_Homo sapiens_hsa051321.79071020
34Lysosome_Homo sapiens_hsa041421.75797995
35Influenza A_Homo sapiens_hsa051641.74817234
36Leishmaniasis_Homo sapiens_hsa051401.74021412
37Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.71806673
38MicroRNAs in cancer_Homo sapiens_hsa052061.70586478
39Proteoglycans in cancer_Homo sapiens_hsa052051.66293485
40Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.63071454
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.62811744
42* Adherens junction_Homo sapiens_hsa045201.61153205
43Nucleotide excision repair_Homo sapiens_hsa034201.58283943
44Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.55688641
45Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.54050099
46Small cell lung cancer_Homo sapiens_hsa052221.48097137
47Toxoplasmosis_Homo sapiens_hsa051451.46597440
48Melanoma_Homo sapiens_hsa052181.40387342
49Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.39749879
50Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.39698937
51Shigellosis_Homo sapiens_hsa051311.38227623
52Pyrimidine metabolism_Homo sapiens_hsa002401.37938606
53Tuberculosis_Homo sapiens_hsa051521.37430995
54PI3K-Akt signaling pathway_Homo sapiens_hsa041511.29154534
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.27913716
56Malaria_Homo sapiens_hsa051441.25692687
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.25113806
58mRNA surveillance pathway_Homo sapiens_hsa030151.22136297
59Protein digestion and absorption_Homo sapiens_hsa049741.21311299
60Homologous recombination_Homo sapiens_hsa034401.20633771
61HTLV-I infection_Homo sapiens_hsa051661.20535281
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.15745025
63Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.14972419
64Measles_Homo sapiens_hsa051621.13670817
65Thyroid cancer_Homo sapiens_hsa052161.12024626
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.09765799
67Staphylococcus aureus infection_Homo sapiens_hsa051501.09436202
68Sulfur metabolism_Homo sapiens_hsa009201.07714652
69Wnt signaling pathway_Homo sapiens_hsa043101.06885458
70Basal transcription factors_Homo sapiens_hsa030221.05545196
71Jak-STAT signaling pathway_Homo sapiens_hsa046301.05053727
72Hepatitis C_Homo sapiens_hsa051601.03832808
73Regulation of actin cytoskeleton_Homo sapiens_hsa048101.03355764
74Chronic myeloid leukemia_Homo sapiens_hsa052200.99754913
75Pathways in cancer_Homo sapiens_hsa052000.98687556
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.96776885
77Amoebiasis_Homo sapiens_hsa051460.96065442
78Viral carcinogenesis_Homo sapiens_hsa052030.93276581
79RNA degradation_Homo sapiens_hsa030180.93019027
80Prostate cancer_Homo sapiens_hsa052150.92703531
81Epstein-Barr virus infection_Homo sapiens_hsa051690.92655928
82Vitamin B6 metabolism_Homo sapiens_hsa007500.92561875
83Hematopoietic cell lineage_Homo sapiens_hsa046400.91693097
84Asthma_Homo sapiens_hsa053100.91077169
85Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.87341575
86Biosynthesis of amino acids_Homo sapiens_hsa012300.86341575
87Fanconi anemia pathway_Homo sapiens_hsa034600.85643818
88Notch signaling pathway_Homo sapiens_hsa043300.84134943
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.82340790
90Rap1 signaling pathway_Homo sapiens_hsa040150.81472188
91Graft-versus-host disease_Homo sapiens_hsa053320.81168720
92Allograft rejection_Homo sapiens_hsa053300.80645307
93Intestinal immune network for IgA production_Homo sapiens_hsa046720.80278071
94HIF-1 signaling pathway_Homo sapiens_hsa040660.80175438
95Complement and coagulation cascades_Homo sapiens_hsa046100.79826761
96Tight junction_Homo sapiens_hsa045300.79643789
97Central carbon metabolism in cancer_Homo sapiens_hsa052300.78242954
98Cyanoamino acid metabolism_Homo sapiens_hsa004600.75582618
99mTOR signaling pathway_Homo sapiens_hsa041500.73406065
100Oocyte meiosis_Homo sapiens_hsa041140.73166459
101Arginine and proline metabolism_Homo sapiens_hsa003300.73129536
102Apoptosis_Homo sapiens_hsa042100.72987704
103Phagosome_Homo sapiens_hsa041450.71317349
104Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68952797
105Viral myocarditis_Homo sapiens_hsa054160.68425040
106Colorectal cancer_Homo sapiens_hsa052100.67264646
107Dilated cardiomyopathy_Homo sapiens_hsa054140.66032379
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65531353
109Vibrio cholerae infection_Homo sapiens_hsa051100.63914130
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.63885604
111Fructose and mannose metabolism_Homo sapiens_hsa000510.62354135
112Sphingolipid metabolism_Homo sapiens_hsa006000.61242855
113TNF signaling pathway_Homo sapiens_hsa046680.61231185
114Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.59737189
115Hepatitis B_Homo sapiens_hsa051610.59477034
116Glutathione metabolism_Homo sapiens_hsa004800.58182250
117Purine metabolism_Homo sapiens_hsa002300.57167621
118Pancreatic cancer_Homo sapiens_hsa052120.56032881
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54580754
120Folate biosynthesis_Homo sapiens_hsa007900.52624042
121Chemokine signaling pathway_Homo sapiens_hsa040620.52002508
122SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50046243
123Acute myeloid leukemia_Homo sapiens_hsa052210.48217260
124Sulfur relay system_Homo sapiens_hsa041220.47476666
125Leukocyte transendothelial migration_Homo sapiens_hsa046700.47414320
126Pentose phosphate pathway_Homo sapiens_hsa000300.44790086
127Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44779088
128MAPK signaling pathway_Homo sapiens_hsa040100.44729981
129Prolactin signaling pathway_Homo sapiens_hsa049170.44585882
130Legionellosis_Homo sapiens_hsa051340.43767098
131Melanogenesis_Homo sapiens_hsa049160.43438790
132Endometrial cancer_Homo sapiens_hsa052130.41550731
133Galactose metabolism_Homo sapiens_hsa000520.41319722
134Mineral absorption_Homo sapiens_hsa049780.41261133
135Renal cell carcinoma_Homo sapiens_hsa052110.40943047
136Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39290873
137VEGF signaling pathway_Homo sapiens_hsa043700.37422949
138Neurotrophin signaling pathway_Homo sapiens_hsa047220.36898243
139Autoimmune thyroid disease_Homo sapiens_hsa053200.36313171
140Herpes simplex infection_Homo sapiens_hsa051680.35914769
141Drug metabolism - other enzymes_Homo sapiens_hsa009830.35658864
142Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35062089
143Ras signaling pathway_Homo sapiens_hsa040140.33210511
144Cysteine and methionine metabolism_Homo sapiens_hsa002700.33110892
145FoxO signaling pathway_Homo sapiens_hsa040680.32438982
146Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32322263
147Endocytosis_Homo sapiens_hsa041440.31595063
148N-Glycan biosynthesis_Homo sapiens_hsa005100.30991370
149Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.30603669
150Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30577997
151Gap junction_Homo sapiens_hsa045400.29860994
152Insulin resistance_Homo sapiens_hsa049310.29674805

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