SNAI2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)6.37957927
2bone trabecula formation (GO:0060346)5.70293059
3mesenchymal-epithelial cell signaling (GO:0060638)5.61511676
4chondrocyte proliferation (GO:0035988)5.58278882
5cell proliferation involved in metanephros development (GO:0072203)5.20011918
6metanephric mesenchyme development (GO:0072075)5.16127116
7sequestering of extracellular ligand from receptor (GO:0035581)5.07757210
8regulation of plasminogen activation (GO:0010755)5.01699764
9kidney mesenchyme development (GO:0072074)4.99713599
10collagen fibril organization (GO:0030199)4.97169747
11cell proliferation involved in kidney development (GO:0072111)4.91930427
12lateral sprouting from an epithelium (GO:0060601)4.90844622
13mesenchymal cell differentiation involved in kidney development (GO:0072161)4.80038893
14mesenchymal cell differentiation involved in renal system development (GO:2001012)4.80038893
15craniofacial suture morphogenesis (GO:0097094)4.59122537
16skin morphogenesis (GO:0043589)4.54689839
17regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.52206436
18mesenchymal cell proliferation (GO:0010463)4.42995700
19* cell migration involved in heart development (GO:0060973)4.28242357
20planar cell polarity pathway involved in neural tube closure (GO:0090179)4.26319794
21regulation of non-canonical Wnt signaling pathway (GO:2000050)4.14795835
22regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)4.14714690
23extracellular regulation of signal transduction (GO:1900115)4.08713595
24extracellular negative regulation of signal transduction (GO:1900116)4.08713595
25regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.07808229
26embryonic cranial skeleton morphogenesis (GO:0048701)4.07581905
27middle ear morphogenesis (GO:0042474)4.03663863
28protein heterotrimerization (GO:0070208)4.02385799
29cell adhesion mediated by integrin (GO:0033627)3.98863170
30chondrocyte development (GO:0002063)3.96590324
31outer ear morphogenesis (GO:0042473)3.96335537
32cranial suture morphogenesis (GO:0060363)3.95974213
33embryonic skeletal joint morphogenesis (GO:0060272)3.91904370
34G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.90827675
35prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.87533765
36cell-substrate junction assembly (GO:0007044)3.86672070
37basement membrane organization (GO:0071711)3.85877459
38regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.79091278
39mesenchymal cell differentiation (GO:0048762)3.74793705
40neuron projection extension involved in neuron projection guidance (GO:1902284)3.74598063
41axon extension involved in axon guidance (GO:0048846)3.74598063
42melanin biosynthetic process (GO:0042438)3.70745488
43dermatan sulfate biosynthetic process (GO:0030208)3.62659283
44extracellular matrix assembly (GO:0085029)3.57444039
45smooth muscle tissue development (GO:0048745)3.51059560
46radial glial cell differentiation (GO:0060019)3.50381194
47* negative regulation of chondrocyte differentiation (GO:0032331)3.40820318
48embryonic forelimb morphogenesis (GO:0035115)3.37017827
49peptidyl-proline hydroxylation (GO:0019511)3.36487635
50dermatan sulfate metabolic process (GO:0030205)3.35255941
51extracellular fibril organization (GO:0043206)3.33196942
52COPII vesicle coating (GO:0048208)3.32457898
53vascular endothelial growth factor signaling pathway (GO:0038084)3.27234146
54negative regulation of embryonic development (GO:0045992)3.25692545
55regulation of transforming growth factor beta2 production (GO:0032909)3.25447129
56branching involved in prostate gland morphogenesis (GO:0060442)3.23579209
57* regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.22946393
58mesonephros development (GO:0001823)3.22423190
59ureteric bud development (GO:0001657)3.21438953
60establishment of tissue polarity (GO:0007164)3.19991858
61establishment of planar polarity (GO:0001736)3.19991858
62extracellular matrix disassembly (GO:0022617)3.19693555
63positive regulation of mesenchymal cell proliferation (GO:0002053)3.17713618
64regulation of integrin-mediated signaling pathway (GO:2001044)3.17408566
65multicellular organismal macromolecule metabolic process (GO:0044259)3.16687883
66mesonephric tubule development (GO:0072164)3.16324225
67endothelial cell morphogenesis (GO:0001886)3.15606233
68type B pancreatic cell proliferation (GO:0044342)3.15213965
69atrioventricular valve morphogenesis (GO:0003181)3.14769864
70melanin metabolic process (GO:0006582)3.14495309
71endodermal cell differentiation (GO:0035987)3.14439887
72protein retention in ER lumen (GO:0006621)3.14308650
73paraxial mesoderm development (GO:0048339)3.14136961
74fibril organization (GO:0097435)3.12977721
75substrate-dependent cell migration (GO:0006929)3.12759540
76positive regulation of cartilage development (GO:0061036)3.11993877
77* desmosome organization (GO:0002934)3.11794153
78regulation of mesenchymal cell proliferation (GO:0010464)3.11346894
79maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.11302497
80positive regulation of smoothened signaling pathway (GO:0045880)3.11244757
81negative regulation of axon extension involved in axon guidance (GO:0048843)3.10955590
82regulation of metalloenzyme activity (GO:0048552)3.09822074
83cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.07944456
84mesenchyme morphogenesis (GO:0072132)3.06869546
85mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.06712000
86secondary metabolite biosynthetic process (GO:0044550)3.06666311
87protein hydroxylation (GO:0018126)3.06232524
88mesodermal cell differentiation (GO:0048333)3.06106269
89head development (GO:0060322)3.05425206
90mesonephric epithelium development (GO:0072163)3.04812957
91multicellular organismal metabolic process (GO:0044236)3.04515723
92cell migration involved in sprouting angiogenesis (GO:0002042)3.02547033
93cellular response to vitamin D (GO:0071305)3.02310832
94convergent extension (GO:0060026)3.01187389
95cell differentiation involved in metanephros development (GO:0072202)3.00372791
96embryonic skeletal system morphogenesis (GO:0048704)2.98233336
97forelimb morphogenesis (GO:0035136)2.96082590
98multicellular organismal catabolic process (GO:0044243)2.95553781
99Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.94730471
100negative chemotaxis (GO:0050919)2.93677098
101mesenchyme development (GO:0060485)2.93201650
102wound healing, spreading of epidermal cells (GO:0035313)2.93027798
103positive regulation of epithelial to mesenchymal transition (GO:0010718)2.91701060
104dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.90929567
105endocardial cushion development (GO:0003197)2.90913003
106collagen metabolic process (GO:0032963)2.90768418
107regulation of establishment of planar polarity (GO:0090175)2.89183836
108lymphangiogenesis (GO:0001946)2.88807205
109regulation of heart morphogenesis (GO:2000826)2.88400799
110regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.88021869
111* palate development (GO:0060021)2.87937854
112positive regulation of blood vessel endothelial cell migration (GO:0043536)2.87596238
113wound healing, spreading of cells (GO:0044319)2.87283309
114cochlea morphogenesis (GO:0090103)2.87030542
115embryonic appendage morphogenesis (GO:0035113)2.86908614
116embryonic limb morphogenesis (GO:0030326)2.86908614
117collagen catabolic process (GO:0030574)2.86879823
118regulation of gonadotropin secretion (GO:0032276)2.85858057
119cell differentiation involved in kidney development (GO:0061005)2.85767435
120cellular response to vitamin (GO:0071295)2.84283829
121muscle cell migration (GO:0014812)2.83824469
122anterior/posterior axis specification, embryo (GO:0008595)2.83072852
123extracellular matrix organization (GO:0030198)2.82637594
124* epithelial to mesenchymal transition (GO:0001837)2.82505163
125* regulation of keratinocyte proliferation (GO:0010837)2.82273951
126extracellular structure organization (GO:0043062)2.81440194
127* neural crest cell development (GO:0014032)2.81249375
128cell surface receptor signaling pathway involved in heart development (GO:0061311)2.81136296
129heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.77246557
130* regulation of cartilage development (GO:0061035)2.77151078
131negative regulation of axon guidance (GO:1902668)2.76946154
132pathway-restricted SMAD protein phosphorylation (GO:0060389)2.76767124
133* regulation of chondrocyte differentiation (GO:0032330)2.76704683
134negative regulation of BMP signaling pathway (GO:0030514)2.76392501
135protein localization to endosome (GO:0036010)2.76280014
136pattern specification involved in kidney development (GO:0061004)2.76181252
137response to BMP (GO:0071772)2.75563655
138cellular response to BMP stimulus (GO:0071773)2.75563655
139organ induction (GO:0001759)2.74979629
140regulation of organ formation (GO:0003156)2.74838861
141notochord development (GO:0030903)2.74365059
142prostate gland epithelium morphogenesis (GO:0060740)2.72118105
143branching involved in ureteric bud morphogenesis (GO:0001658)2.72039863
144keratinocyte proliferation (GO:0043616)2.71836695
145positive regulation of odontogenesis (GO:0042482)2.71681260
146negative regulation of fatty acid transport (GO:2000192)2.71371599
147regulation of axon extension involved in axon guidance (GO:0048841)2.70675302
148skeletal system morphogenesis (GO:0048705)2.70129556
149limb bud formation (GO:0060174)2.70014285
150negative regulation of smooth muscle cell migration (GO:0014912)2.65059409
151face morphogenesis (GO:0060325)2.63051757
152wound healing (GO:0042060)2.59848272
153substrate adhesion-dependent cell spreading (GO:0034446)2.59407272
154pericardium development (GO:0060039)2.59315774
155barbed-end actin filament capping (GO:0051016)2.58745241
156midgut development (GO:0007494)2.58647514
157negative regulation of endothelial cell proliferation (GO:0001937)2.58517382
158negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.56088280
159positive regulation of endothelial cell migration (GO:0010595)2.54215229
160venous blood vessel morphogenesis (GO:0048845)2.53524574
161vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.52853998
162positive regulation of osteoblast proliferation (GO:0033690)2.51878605

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.13860814
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.06748596
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.65453468
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.52917855
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.19342872
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.17570838
7TP63_19390658_ChIP-ChIP_HaCaT_Human3.11427860
8EED_16625203_ChIP-ChIP_MESCs_Mouse3.03878987
9CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.90006909
10WT1_19549856_ChIP-ChIP_CCG9911_Human2.74531227
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.73988872
12PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.55859099
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.55331515
14ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.35523968
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.35452337
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.30913849
17SMAD_19615063_ChIP-ChIP_OVARY_Human2.29716270
18CJUN_26792858_Chip-Seq_BT549_Human2.28824222
19TP53_18474530_ChIP-ChIP_U2OS_Human2.21787177
20* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.21639807
21GBX2_23144817_ChIP-Seq_PC3_Human2.17162575
22EZH2_27304074_Chip-Seq_ESCs_Mouse2.12681726
23EZH2_18974828_ChIP-Seq_MESCs_Mouse2.10697723
24RNF2_18974828_ChIP-Seq_MESCs_Mouse2.10697723
25CLOCK_20551151_ChIP-Seq_293T_Human2.07088171
26SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.01259668
27* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.00126283
28NRF2_20460467_ChIP-Seq_MEFs_Mouse1.96307285
29NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.96307285
30* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.94371794
31BP1_19119308_ChIP-ChIP_Hs578T_Human1.91313465
32CBX2_27304074_Chip-Seq_ESCs_Mouse1.91027431
33TP53_20018659_ChIP-ChIP_R1E_Mouse1.88710551
34BRD4_25478319_ChIP-Seq_HGPS_Human1.88459424
35UBF1/2_26484160_Chip-Seq_HMECs_Human1.86364737
36* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.85276645
37CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.83753698
38CDX2_19796622_ChIP-Seq_MESCs_Mouse1.83129756
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.80945070
40* AR_21909140_ChIP-Seq_LNCAP_Human1.80108557
41PPAR_26484153_Chip-Seq_NCI-H1993_Human1.75753493
42HIF1A_21447827_ChIP-Seq_MCF-7_Human1.74886962
43* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.71261915
44JARID2_20064375_ChIP-Seq_MESCs_Mouse1.71215902
45JARID2_20075857_ChIP-Seq_MESCs_Mouse1.69263831
46* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.68891253
47* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67738606
48POU5F1_16153702_ChIP-ChIP_HESCs_Human1.67684233
49EP300_21415370_ChIP-Seq_HL-1_Mouse1.66807786
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.65739720
51* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.64703867
52FUS_26573619_Chip-Seq_HEK293_Human1.64435462
53HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.63778708
54TP53_16413492_ChIP-PET_HCT116_Human1.60025490
55P300_27058665_Chip-Seq_ZR-75-30cells_Human1.56397951
56* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.55996006
57NFIB_24661679_ChIP-Seq_LUNG_Mouse1.54115452
58ZNF217_24962896_ChIP-Seq_MCF-7_Human1.53171707
59ELK3_25401928_ChIP-Seq_HUVEC_Human1.52233612
60KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.50741386
61EWS_26573619_Chip-Seq_HEK293_Human1.50333578
62RNF2_27304074_Chip-Seq_ESCs_Mouse1.49322924
63EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.49220197
64* GATA2_21666600_ChIP-Seq_HMVEC_Human1.48647416
65AR_21572438_ChIP-Seq_LNCaP_Human1.48285261
66P63_26484246_Chip-Seq_KERATINOCYTES_Human1.47792764
67* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.47643672
68TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.46501062
69* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.46237420
70* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.45826535
71P300_19829295_ChIP-Seq_ESCs_Human1.44863242
72TP53_22127205_ChIP-Seq_IMR90_Human1.40631180
73SALL1_21062744_ChIP-ChIP_HESCs_Human1.40285476
74THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.39875531
75FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.39760110
76ESR1_21235772_ChIP-Seq_MCF-7_Human1.37429778
77SMC1_22415368_ChIP-Seq_MEFs_Mouse1.33394175
78WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.33112325
79MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.32314980
80SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.31071385
81SALL4_18804426_ChIP-ChIP_XEN_Mouse1.26117202
82UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.24884344
83SOX9_24532713_ChIP-Seq_HFSC_Mouse1.23618506
84ISL1_27105846_Chip-Seq_CPCs_Mouse1.22959984
85* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.21626381
86TCF4_18268006_ChIP-ChIP_LS174T_Human1.20209679
87POU3F2_20337985_ChIP-ChIP_501MEL_Human1.19828354
88STAT6_21828071_ChIP-Seq_BEAS2B_Human1.19788369
89AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19144868
90ESR2_21235772_ChIP-Seq_MCF-7_Human1.18559488
91TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.17531305
92* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.16374876
93* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.16374876
94* TP63_23658742_ChIP-Seq_EP156T_Human1.15700608
95MTF2_20144788_ChIP-Seq_MESCs_Mouse1.14229938
96EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.12454139
97RXR_22108803_ChIP-Seq_LS180_Human1.11850624
98TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11397045
99* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11052384
100TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11049011
101TBX20_22328084_ChIP-Seq_HEART_Mouse1.09910687
102TBX20_22080862_ChIP-Seq_HEART_Mouse1.09910687
103OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09447124
104NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.08519974
105* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.08360468
106* SA1_22415368_ChIP-Seq_MEFs_Mouse1.06884015
107CTNNB1_20460455_ChIP-Seq_HCT116_Human1.04993707
108RING1B_27294783_Chip-Seq_NPCs_Mouse1.04825435
109SMAD4_21799915_ChIP-Seq_A2780_Human1.04526540
110* ATF3_27146783_Chip-Seq_COLON_Human1.04200876
111CTBP2_25329375_ChIP-Seq_LNCAP_Human1.02396114
112KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.00556560
113FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.99903691
114SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.99131517
115RNF2_27304074_Chip-Seq_NSC_Mouse0.98738182
116TP53_23651856_ChIP-Seq_MEFs_Mouse0.98139844
117POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.97691400
118AHR_22903824_ChIP-Seq_MCF-7_Human0.97667441
119ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.97655743
120NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.97332628
121SMAD3_21741376_ChIP-Seq_EPCs_Human0.97205863
122EZH2_27294783_Chip-Seq_ESCs_Mouse0.97163637
123SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97015447
124SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96886671
125FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95989848
126SUZ12_27294783_Chip-Seq_ESCs_Mouse0.95924151
127* SOX2_20726797_ChIP-Seq_SW620_Human0.95588056
128BCAT_22108803_ChIP-Seq_LS180_Human0.95136111
129TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94915864
130NFI_21473784_ChIP-Seq_ESCs_Mouse0.94703523
131FOXM1_26456572_ChIP-Seq_MCF-7_Human0.93939521
132NANOG_18555785_Chip-Seq_ESCs_Mouse0.93509167
133PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.93447079
134PCGF2_27294783_Chip-Seq_NPCs_Mouse0.93087714
135TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93012745
136EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92490484
137PCGF2_27294783_Chip-Seq_ESCs_Mouse0.92232739
138* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91096576
139KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.89495354
140KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.89495354
141KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.89495354
142TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.88575988
143PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.86977827
144PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.85614714
145ZNF263_19887448_ChIP-Seq_K562_Human0.85482087
146ARNT_22903824_ChIP-Seq_MCF-7_Human0.85124037
147ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.83849635
148FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.83599505
149PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.83433818

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005503_abnormal_tendon_morphology5.34607420
2MP0008438_abnormal_cutaneous_collagen5.19263718
3MP0005275_abnormal_skin_tensile3.49980163
4MP0010030_abnormal_orbit_morphology3.36905938
5MP0009250_abnormal_appendicular_skeleto3.23674838
6MP0003279_aneurysm3.19168774
7MP0000566_synostosis2.95838112
8MP0003385_abnormal_body_wall2.74319055
9MP0009384_cardiac_valve_regurgitation2.68498701
10MP0003705_abnormal_hypodermis_morpholog2.51413777
11MP0004272_abnormal_basement_membrane2.48244741
12MP0005508_abnormal_skeleton_morphology2.46163627
13MP0002249_abnormal_larynx_morphology2.38499221
14MP0005257_abnormal_intraocular_pressure2.28326673
15MP0000049_abnormal_middle_ear2.22963997
16MP0003950_abnormal_plasma_membrane2.22874933
17MP0003942_abnormal_urinary_system2.22023985
18MP0000762_abnormal_tongue_morphology2.13453143
19MP0002282_abnormal_trachea_morphology2.09969969
20MP0009053_abnormal_anal_canal2.07416137
21MP0003122_maternal_imprinting2.00847480
22MP0001958_emphysema1.97986640
23MP0000013_abnormal_adipose_tissue1.88661736
24MP0003937_abnormal_limbs/digits/tail_de1.88484981
25* MP0003755_abnormal_palate_morphology1.87101168
26MP0001299_abnormal_eye_distance/1.86590477
27MP0002877_abnormal_melanocyte_morpholog1.82834423
28MP0001346_abnormal_lacrimal_gland1.82153931
29MP0000163_abnormal_cartilage_morphology1.77050403
30MP0003941_abnormal_skin_development1.76209130
31MP0002108_abnormal_muscle_morphology1.74122865
32MP0010368_abnormal_lymphatic_system1.71994151
33MP0004134_abnormal_chest_morphology1.70785754
34MP0000534_abnormal_ureter_morphology1.70189805
35* MP0002938_white_spotting1.68167240
36MP0002932_abnormal_joint_morphology1.63346643
37MP0002233_abnormal_nose_morphology1.61079404
38MP0002115_abnormal_skeleton_extremities1.57212234
39MP0005171_absent_coat_pigmentation1.55199905
40MP0002060_abnormal_skin_morphology1.54255190
41MP0002109_abnormal_limb_morphology1.53347826
42MP0000428_abnormal_craniofacial_morphol1.51004342
43MP0000372_irregular_coat_pigmentation1.50941514
44MP0005408_hypopigmentation1.50112202
45MP0002896_abnormal_bone_mineralization1.49467645
46MP0006054_spinal_hemorrhage1.49250041
47MP0000516_abnormal_urinary_system1.49117417
48MP0005367_renal/urinary_system_phenotyp1.49117417
49MP0002116_abnormal_craniofacial_bone1.42767510
50MP0002295_abnormal_pulmonary_circulatio1.41674651
51* MP0003935_abnormal_craniofacial_develop1.39562275
52MP0000767_abnormal_smooth_muscle1.38211034
53MP0002113_abnormal_skeleton_development1.38065965
54MP0002177_abnormal_outer_ear1.37389729
55MP0000537_abnormal_urethra_morphology1.35711240
56MP0005360_urolithiasis1.34664027
57MP0001270_distended_abdomen1.31830640
58MP0000432_abnormal_head_morphology1.30139901
59MP0005390_skeleton_phenotype1.29192680
60MP0005409_darkened_coat_color1.27843595
61MP0001879_abnormal_lymphatic_vessel1.27199676
62MP0000678_abnormal_parathyroid_gland1.27129920
63MP0009780_abnormal_chondrocyte_physiolo1.26194204
64MP0001542_abnormal_bone_strength1.25364597
65MP0000751_myopathy1.23872199
66MP0001849_ear_inflammation1.23279453
67MP0000003_abnormal_adipose_tissue1.22666293
68MP0005023_abnormal_wound_healing1.20316615
69MP0005623_abnormal_meninges_morphology1.20284557
70MP0000733_abnormal_muscle_development1.16149731
71MP0003121_genomic_imprinting1.15017076
72MP0005248_abnormal_Harderian_gland1.14641599
73MP0000467_abnormal_esophagus_morphology1.14473377
74MP0009697_abnormal_copulation1.13127892
75MP0003115_abnormal_respiratory_system1.10356291
76MP0001243_abnormal_dermal_layer1.10237664
77MP0000579_abnormal_nail_morphology1.08592962
78MP0000569_abnormal_digit_pigmentation1.04592099
79MP0005164_abnormal_response_to1.03327264
80MP0001661_extended_life_span1.03220138
81MP0003566_abnormal_cell_adhesion1.02455331
82MP0002111_abnormal_tail_morphology1.01546461
83MP0002098_abnormal_vibrissa_morphology0.99543154
84MP0002933_joint_inflammation0.98689562
85MP0005670_abnormal_white_adipose0.97875578
86MP0001293_anophthalmia0.96008354
87MP0010352_gastrointestinal_tract_polyps0.95268408
88MP0002114_abnormal_axial_skeleton0.94654577
89MP0000015_abnormal_ear_pigmentation0.93552173
90MP0000749_muscle_degeneration0.92531776
91MP0000613_abnormal_salivary_gland0.92031306
92MP0003136_yellow_coat_color0.91569537
93MP0000383_abnormal_hair_follicle0.91433244
94MP0002234_abnormal_pharynx_morphology0.90871252
95MP0003938_abnormal_ear_development0.90009677
96MP0005595_abnormal_vascular_smooth0.88810324
97MP0003091_abnormal_cell_migration0.88723371
98MP0002998_abnormal_bone_remodeling0.85626143
99MP0002277_abnormal_respiratory_mucosa0.83873666
100MP0001177_atelectasis0.83794012
101MP0008789_abnormal_olfactory_epithelium0.82887647
102MP0001216_abnormal_epidermal_layer0.81763385
103MP0001175_abnormal_lung_morphology0.81191365
104MP0010771_integument_phenotype0.80384548
105* MP0001340_abnormal_eyelid_morphology0.78888530
106MP0003795_abnormal_bone_structure0.78133948
107MP0000427_abnormal_hair_cycle0.77615141
108MP0002168_other_aberrant_phenotype0.77373737
109MP0000647_abnormal_sebaceous_gland0.76947897
110MP0002102_abnormal_ear_morphology0.76080711
111MP0000759_abnormal_skeletal_muscle0.75809724
112* MP0005193_abnormal_anterior_eye0.75354199
113MP0000750_abnormal_muscle_regeneration0.75166509
114MP0002796_impaired_skin_barrier0.70856465
115MP0004381_abnormal_hair_follicle0.70816386
116MP0003453_abnormal_keratinocyte_physiol0.69008416
117MP0005197_abnormal_uvea_morphology0.68294610
118MP0002133_abnormal_respiratory_system0.67006053
119MP0005388_respiratory_system_phenotype0.67006053
120MP0004858_abnormal_nervous_system0.66301991
121MP0002128_abnormal_blood_circulation0.65027454
122MP0000681_abnormal_thyroid_gland0.64988733
123MP0002697_abnormal_eye_size0.64876781
124MP0001286_abnormal_eye_development0.64861452
125MP0001614_abnormal_blood_vessel0.61068698
126MP0002925_abnormal_cardiovascular_devel0.60136671
127MP0002132_abnormal_respiratory_system0.59405855
128MP0002163_abnormal_gland_morphology0.59397369
129MP0005187_abnormal_penis_morphology0.59155341
130MP0000538_abnormal_urinary_bladder0.59035134
131MP0000462_abnormal_digestive_system0.58292726
132MP0005501_abnormal_skin_physiology0.57262162
133MP0004883_abnormal_blood_vessel0.56123677
134MP0003283_abnormal_digestive_organ0.55542052
135MP0002089_abnormal_postnatal_growth/wei0.54437332

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.07461411
2Premature rupture of membranes (HP:0001788)5.07306888
3Short 4th metacarpal (HP:0010044)3.74049866
4Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.74049866
5Follicular hyperkeratosis (HP:0007502)3.71797196
6Shallow orbits (HP:0000586)3.68710202
7Atrophic scars (HP:0001075)3.55168004
8Aortic aneurysm (HP:0004942)3.50223945
9Soft skin (HP:0000977)3.48145677
10Aortic dissection (HP:0002647)3.46675056
11Broad metatarsal (HP:0001783)3.44161908
12Abnormality of the parietal bone (HP:0002696)3.41086431
13Mesomelia (HP:0003027)3.37341083
14Bell-shaped thorax (HP:0001591)3.31949620
15Vertebral compression fractures (HP:0002953)3.19299070
16Neonatal short-limb short stature (HP:0008921)3.18142048
17Abnormality of dentin (HP:0010299)3.13092947
18Spinal cord lesions (HP:0100561)3.09676929
19Syringomyelia (HP:0003396)3.09676929
20Microglossia (HP:0000171)3.06522893
21Spondylolisthesis (HP:0003302)2.91297045
22Mitral valve prolapse (HP:0001634)2.84236584
23Hypoplasia of the iris (HP:0007676)2.83234972
24Alopecia of scalp (HP:0002293)2.80989221
25Wormian bones (HP:0002645)2.77768678
26Abnormality of the fetal cardiovascular system (HP:0010948)2.76369832
27Abnormal umbilical cord blood vessels (HP:0011403)2.76369832
28Single umbilical artery (HP:0001195)2.76369832
29Biconcave vertebral bodies (HP:0004586)2.76207075
30Peritonitis (HP:0002586)2.74479528
31Bladder diverticulum (HP:0000015)2.72424614
32Abnormality of the 4th metacarpal (HP:0010012)2.71497541
33Ankle contracture (HP:0006466)2.70125333
34Vascular tortuosity (HP:0004948)2.65628144
35Cervical subluxation (HP:0003308)2.65183811
36Short middle phalanx of the 5th finger (HP:0004220)2.60364940
37Midline defect of the nose (HP:0004122)2.60129398
38Osteolytic defects of the hand bones (HP:0009699)2.56763818
39Osteolytic defects of the phalanges of the hand (HP:0009771)2.56763818
40Wide anterior fontanel (HP:0000260)2.51962888
41Coronal craniosynostosis (HP:0004440)2.49713769
42Blue sclerae (HP:0000592)2.49537302
43Dilatation of the ascending aorta (HP:0005111)2.48942293
44Fragile skin (HP:0001030)2.48220078
45Reduced subcutaneous adipose tissue (HP:0003758)2.44248720
46Aortic regurgitation (HP:0001659)2.44036299
47Spinal rigidity (HP:0003306)2.40490724
48Abnormality of incisor morphology (HP:0011063)2.39420948
49Abnormality of the umbilical cord (HP:0010881)2.39307786
50Nasolacrimal duct obstruction (HP:0000579)2.38344539
51Milia (HP:0001056)2.34710963
52Onycholysis (HP:0001806)2.33176005
53Arterial tortuosity (HP:0005116)2.30167118
54Type 1 muscle fiber predominance (HP:0003803)2.28986888
55Abnormal delivery (HP:0001787)2.28968371
56* White forelock (HP:0002211)2.26911775
57Abnormality of the nasolacrimal system (HP:0000614)2.22320679
58Broad toe (HP:0001837)2.21556355
59Mildly elevated creatine phosphokinase (HP:0008180)2.21552703
60Infantile muscular hypotonia (HP:0008947)2.20440979
61Abnormality of the phalanges of the 2nd finger (HP:0009541)2.19870362
62Morphological abnormality of the middle ear (HP:0008609)2.19729909
63Cardiovascular calcification (HP:0011915)2.18935066
64Disproportionate tall stature (HP:0001519)2.17556975
65Vitreoretinal degeneration (HP:0000655)2.14748403
66Ulnar bowing (HP:0003031)2.13267346
67Overgrowth (HP:0001548)2.13004318
68Hypoplastic ischia (HP:0003175)2.12554763
69Decreased skull ossification (HP:0004331)2.11607140
70Hepatoblastoma (HP:0002884)2.10281971
71Elbow flexion contracture (HP:0002987)2.09604088
72Flat capital femoral epiphysis (HP:0003370)2.09360314
73Fragile nails (HP:0001808)2.06241823
74Abnormality of the distal phalanx of the thumb (HP:0009617)2.04403957
75Abnormality of the lacrimal duct (HP:0011481)2.04295062
76Increased variability in muscle fiber diameter (HP:0003557)2.01347375
77Broad long bones (HP:0005622)2.00477425
78Trigonocephaly (HP:0000243)1.99946384
79* Patchy hypopigmentation of hair (HP:0011365)1.99835133
80Mitral stenosis (HP:0001718)1.99468788
81Bowel diverticulosis (HP:0005222)1.98567372
82Increased number of teeth (HP:0011069)1.98076125
83Cerebral aneurysm (HP:0004944)1.97012724
84Delayed cranial suture closure (HP:0000270)1.96937940
85Short clavicles (HP:0000894)1.96845196
86Abnormal ossification of hand bones (HP:0005921)1.96417414
87Abnormality of nail color (HP:0100643)1.95879193
88Tracheomalacia (HP:0002779)1.95775136
89Abnormality of the 2nd finger (HP:0004100)1.95238802
90Aplasia involving bones of the extremities (HP:0009825)1.94874641
91Aplasia involving bones of the upper limbs (HP:0009823)1.94874641
92Aplasia of the phalanges of the hand (HP:0009802)1.94874641
93Hypopigmentation of the fundus (HP:0007894)1.94097783
94Asymmetry of the thorax (HP:0001555)1.91716029
95Wrist flexion contracture (HP:0001239)1.91649406
96Delayed closure of the anterior fontanelle (HP:0001476)1.91304094
97Pterygium (HP:0001059)1.90359864
98Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.90019381
99Genu recurvatum (HP:0002816)1.89955490
100Abnormalities of placenta or umbilical cord (HP:0001194)1.89896226
101Abnormal hand bone ossification (HP:0010660)1.89773239
102Abnormality of the ischium (HP:0003174)1.89596896
103Aneurysm (HP:0002617)1.88802911
104Slender build (HP:0001533)1.88479490
105Plantar hyperkeratosis (HP:0007556)1.88171019
106Joint laxity (HP:0001388)1.87709599
107Abnormality of the incisor (HP:0000676)1.84714841
108Aplasia cutis congenita (HP:0001057)1.84001411
109Abnormality of the nasal septum (HP:0000419)1.83895356
110Natal tooth (HP:0000695)1.83652082
111Limited elbow extension (HP:0001377)1.83268421
112Popliteal pterygium (HP:0009756)1.83245113
113Limited hip movement (HP:0008800)1.82586852
114Abnormality of skull ossification (HP:0002703)1.82582546
115Broad hallux (HP:0010055)1.82370177
116Deviation of the hallux (HP:0010051)1.82367695
117Absent frontal sinuses (HP:0002688)1.81458705
118Abnormality of carpal bone ossification (HP:0006257)1.80399975
119Abnormality of the middle phalanges of the hand (HP:0009833)1.80284079
120Abnormality of the acetabulum (HP:0003170)1.80210792
121Short middle phalanx of finger (HP:0005819)1.80170790
122Knee flexion contracture (HP:0006380)1.79988939
123Short nail (HP:0001799)1.79932460
124Hyperextensible skin (HP:0000974)1.79821538
125Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.79428183
126Abnormality of the phalanges of the hallux (HP:0010057)1.79345116
127Cutaneous finger syndactyly (HP:0010554)1.79296023
128Mitral regurgitation (HP:0001653)1.79274890
129Keratoconus (HP:0000563)1.78770185
130Increased corneal curvature (HP:0100692)1.78770185
131Osteoarthritis (HP:0002758)1.78569187
132Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.76881301
133Ectopia lentis (HP:0001083)1.76692398
134Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.76146971
135Aortic valve stenosis (HP:0001650)1.75874433
136Down-sloping shoulders (HP:0200021)1.75711143
137Thick nail (HP:0001805)1.75409566
138Abnormality of the middle phalanges of the toes (HP:0010183)1.75163860
139Broad phalanx (HP:0006009)1.75157892
140Aplasia/Hypoplasia of the clavicles (HP:0006710)1.74571606
141Venous abnormality (HP:0002624)1.71911132
142Breech presentation (HP:0001623)1.70019338
143Inguinal hernia (HP:0000023)1.68689023
144Aplasia of the musculature (HP:0100854)1.68638068
145Hallux valgus (HP:0001822)1.67881332
146Thin ribs (HP:0000883)1.66620034
147Delayed gross motor development (HP:0002194)1.65220185
148Camptodactyly of toe (HP:0001836)1.64939345
149Generalized amyotrophy (HP:0003700)1.64535428
150Round ear (HP:0100830)1.62910632
151Striae distensae (HP:0001065)1.62718473
152Abnormality of skeletal muscle fiber size (HP:0012084)1.61517915

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR24.58862633
2LATS24.06896951
3LATS14.00346976
4EPHA33.60562490
5EPHB23.11858018
6SIK12.95874608
7NUAK12.79633749
8SIK32.57592798
9STK38L2.39480797
10ERBB32.37795654
11PDGFRA2.34463495
12ZAK2.17611234
13NTRK12.15520389
14RPS6KA42.12337932
15MST1R2.05737086
16CDK82.01327977
17FRK1.86055434
18FGFR21.81435246
19RIPK11.70060445
20NEK11.63370857
21PIK3CA1.59547359
22MKNK11.59219411
23TAOK21.58620469
24DMPK1.55136511
25FLT31.51386489
26FER1.50174794
27NEK91.49976108
28MYLK1.48900471
29STK31.48128299
30EIF2AK21.48081737
31MAP2K31.43646447
32TRPM71.36218398
33FGFR11.34798409
34MKNK21.33364610
35PIK3CG1.27439796
36TTN1.27241478
37MAP3K31.23162304
38STK381.23004595
39WEE11.22975858
40PTK2B1.22509940
41LMTK21.20570953
42BRD41.19105911
43TGFBR21.15021364
44EPHA21.14940223
45PAK21.14825825
46PTK21.11928166
47MET1.06937089
48ROCK11.06830092
49PDK21.06294526
50WNK11.06020937
51BMPR1B1.04059190
52CDK121.02753487
53GSK3A1.00613597
54PLK20.95097133
55PNCK0.93498654
56PAK30.93255144
57MAP3K60.93066548
58PDGFRB0.92627471
59TGFBR10.83543000
60MELK0.82929094
61TRIB30.81286549
62BCR0.77196614
63PRKD20.74763795
64ARAF0.74013556
65AKT30.73938231
66MAP3K120.71595056
67CASK0.71102396
68CHUK0.68053110
69GRK70.66653173
70PRKCE0.66250955
71ERN10.65392813
72INSRR0.64088041
73TESK10.64067273
74MAP3K140.63098743
75EPHB10.62414429
76SGK30.61209161
77MUSK0.60098548
78CSNK1A1L0.59058044
79MAPK70.58877736
80ADRBK10.58301226
81CCNB10.57930751
82BMX0.57264646
83ICK0.56766182
84CLK10.56269530
85RPS6KA20.56259731
86LIMK10.56150539
87YES10.55934640
88PTK60.53449978
89PRKD10.52873729
90ERBB20.52470810
91INSR0.51938843
92PIM20.50708784
93STK240.50604599
94NEK60.50336507
95KIT0.50248925
96IGF1R0.49921251
97MAPK130.49732517
98KDR0.48920266
99PLK30.48533365
100NEK20.48399685
101GRK50.48121902
102CDK30.47013921
103MAPKAPK30.46666514
104CDK70.46152091
105PRKG20.45427494
106PRKCH0.44921085
107NLK0.43611547
108PAK40.42782361
109ERBB40.42739873
110SGK4940.40744422
111SGK2230.40744422
112CDC42BPA0.39807286
113MTOR0.39492653
114MAP2K10.38402822
115PKN20.38135395
116CAMK1D0.37457267
117PAK60.37282729
118MAPK10.36741689
119MOS0.35535746
120PBK0.34806034
121IRAK10.34316747
122DAPK30.33853041
123CAMK2G0.32537969
124ABL10.32140769
125ROCK20.30702207
126BRSK10.30452563
127MARK30.29918046
128PAK10.29912421
129CDK90.28657919
130TIE10.28086192
131CDK60.27907902
132SRC0.27900942
133CHEK20.27232679
134MAPKAPK20.27059595
135JAK30.26971950
136BRSK20.26693112
137IKBKB0.26591626
138CAMK2D0.25987967
139ILK0.25254230
140ABL20.24430867
141PRKD30.23798063
142GRK10.23675098
143CSNK1G10.23348201
144JAK10.22922437

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.83684137
2Basal cell carcinoma_Homo sapiens_hsa052173.37634190
3Hedgehog signaling pathway_Homo sapiens_hsa043402.78623805
4Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.71736681
5Focal adhesion_Homo sapiens_hsa045102.55693843
6TGF-beta signaling pathway_Homo sapiens_hsa043502.49024202
7Sulfur metabolism_Homo sapiens_hsa009202.39561547
8* Adherens junction_Homo sapiens_hsa045202.13486542
9Malaria_Homo sapiens_hsa051442.09709934
10Protein digestion and absorption_Homo sapiens_hsa049742.09408280
11* Hippo signaling pathway_Homo sapiens_hsa043902.09402685
12Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.00072289
13Proteoglycans in cancer_Homo sapiens_hsa052051.97870311
14Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.93925173
15Melanoma_Homo sapiens_hsa052181.93672400
16Wnt signaling pathway_Homo sapiens_hsa043101.87644771
17PI3K-Akt signaling pathway_Homo sapiens_hsa041511.80700798
18MicroRNAs in cancer_Homo sapiens_hsa052061.79896028
19Sulfur relay system_Homo sapiens_hsa041221.73218987
20Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.70593359
21Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.67780941
22One carbon pool by folate_Homo sapiens_hsa006701.65952767
23Axon guidance_Homo sapiens_hsa043601.63058058
24Dilated cardiomyopathy_Homo sapiens_hsa054141.60960634
25Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.59805897
26Prostate cancer_Homo sapiens_hsa052151.53242220
27AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.47899135
28Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.42887553
29Small cell lung cancer_Homo sapiens_hsa052221.42021107
30Pathways in cancer_Homo sapiens_hsa052001.38680142
31Amoebiasis_Homo sapiens_hsa051461.38170411
32TNF signaling pathway_Homo sapiens_hsa046681.26563953
33Regulation of actin cytoskeleton_Homo sapiens_hsa048101.22890335
34Galactose metabolism_Homo sapiens_hsa000521.19365251
35Rap1 signaling pathway_Homo sapiens_hsa040151.18620087
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.18357026
37Vibrio cholerae infection_Homo sapiens_hsa051101.15700797
38p53 signaling pathway_Homo sapiens_hsa041151.14811627
39HTLV-I infection_Homo sapiens_hsa051661.09813064
40Transcriptional misregulation in cancer_Homo sapiens_hsa052021.08261970
41Tyrosine metabolism_Homo sapiens_hsa003501.05863399
42Thyroid cancer_Homo sapiens_hsa052161.05282025
43Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.05134243
44Arginine biosynthesis_Homo sapiens_hsa002201.04371067
45Bladder cancer_Homo sapiens_hsa052191.01229074
46Prion diseases_Homo sapiens_hsa050201.00936638
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.99648373
48Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.91639713
49Chemical carcinogenesis_Homo sapiens_hsa052040.88788624
50Ovarian steroidogenesis_Homo sapiens_hsa049130.88736287
51Central carbon metabolism in cancer_Homo sapiens_hsa052300.88466320
52Arachidonic acid metabolism_Homo sapiens_hsa005900.85249043
53Gap junction_Homo sapiens_hsa045400.85072919
54Shigellosis_Homo sapiens_hsa051310.84279885
55Viral myocarditis_Homo sapiens_hsa054160.83749754
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.80985273
57NF-kappa B signaling pathway_Homo sapiens_hsa040640.79969437
58Ras signaling pathway_Homo sapiens_hsa040140.79607292
59Cell cycle_Homo sapiens_hsa041100.79016445
60Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.78550100
61Chronic myeloid leukemia_Homo sapiens_hsa052200.77931161
62Notch signaling pathway_Homo sapiens_hsa043300.77913191
63Protein export_Homo sapiens_hsa030600.77844423
64Leukocyte transendothelial migration_Homo sapiens_hsa046700.77347464
65Other glycan degradation_Homo sapiens_hsa005110.77246974
66Melanogenesis_Homo sapiens_hsa049160.75019733
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.73486225
68Phagosome_Homo sapiens_hsa041450.71667270
69Folate biosynthesis_Homo sapiens_hsa007900.71164402
70Glycosaminoglycan degradation_Homo sapiens_hsa005310.70353688
71Hepatitis B_Homo sapiens_hsa051610.70232377
72Retinol metabolism_Homo sapiens_hsa008300.68971641
73Lysine degradation_Homo sapiens_hsa003100.67710944
74Tight junction_Homo sapiens_hsa045300.67652905
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67497241
76Toll-like receptor signaling pathway_Homo sapiens_hsa046200.66454205
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.64398769
78Endocytosis_Homo sapiens_hsa041440.64095979
79Pancreatic cancer_Homo sapiens_hsa052120.63677430
80Platelet activation_Homo sapiens_hsa046110.62782447
81Toxoplasmosis_Homo sapiens_hsa051450.62629647
82Basal transcription factors_Homo sapiens_hsa030220.59485969
83Renal cell carcinoma_Homo sapiens_hsa052110.58947430
84Complement and coagulation cascades_Homo sapiens_hsa046100.57802673
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57649004
86Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57547345
87Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.57314159
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.56666088
89Jak-STAT signaling pathway_Homo sapiens_hsa046300.55138161
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54232322
91Autoimmune thyroid disease_Homo sapiens_hsa053200.53654390
92Measles_Homo sapiens_hsa051620.53177437
93Rheumatoid arthritis_Homo sapiens_hsa053230.52503338
94Dorso-ventral axis formation_Homo sapiens_hsa043200.51202120
95Caffeine metabolism_Homo sapiens_hsa002320.50680078
96Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49186036
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48742315
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48077166
99FoxO signaling pathway_Homo sapiens_hsa040680.48012019
100Hematopoietic cell lineage_Homo sapiens_hsa046400.47599107
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46553186
102Renin secretion_Homo sapiens_hsa049240.45623713
103Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45038009
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44141583
105Colorectal cancer_Homo sapiens_hsa052100.44060619
106Cyanoamino acid metabolism_Homo sapiens_hsa004600.43559005
107Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43484226
108Apoptosis_Homo sapiens_hsa042100.43420435
109African trypanosomiasis_Homo sapiens_hsa051430.43103943
110GnRH signaling pathway_Homo sapiens_hsa049120.41963462
111Biosynthesis of amino acids_Homo sapiens_hsa012300.41894988
112Fanconi anemia pathway_Homo sapiens_hsa034600.41356692
113Sphingolipid metabolism_Homo sapiens_hsa006000.40921286
114Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39694288
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.38292124
116Renin-angiotensin system_Homo sapiens_hsa046140.38284732
117Mineral absorption_Homo sapiens_hsa049780.38142519
118Leishmaniasis_Homo sapiens_hsa051400.37813066
119Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36982895
120MAPK signaling pathway_Homo sapiens_hsa040100.36681372
121Herpes simplex infection_Homo sapiens_hsa051680.36536758
122cGMP-PKG signaling pathway_Homo sapiens_hsa040220.35841766
123Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35060878
124Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.33898413
125ErbB signaling pathway_Homo sapiens_hsa040120.33825271
126Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33718291
127Glioma_Homo sapiens_hsa052140.33168981
128Arginine and proline metabolism_Homo sapiens_hsa003300.31155312
129N-Glycan biosynthesis_Homo sapiens_hsa005100.30539063
130Glutathione metabolism_Homo sapiens_hsa004800.29356870
131AMPK signaling pathway_Homo sapiens_hsa041520.28061210
132Endometrial cancer_Homo sapiens_hsa052130.27741964
133Estrogen signaling pathway_Homo sapiens_hsa049150.27686199
134Selenocompound metabolism_Homo sapiens_hsa004500.27298503
135GABAergic synapse_Homo sapiens_hsa047270.27218405
136Pertussis_Homo sapiens_hsa051330.25141040
137Circadian rhythm_Homo sapiens_hsa047100.21798465
138Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.20591863
139Cysteine and methionine metabolism_Homo sapiens_hsa002700.19850454

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