SNAI3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: SNAI3 is a member of the SNAIL gene family, named for the Drosophila snail gene, which plays roles in mesodermal formation during embryogenesis (Katoh and Katoh, 2003 [PubMed 12579345]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative T cell selection (GO:0043383)5.41576608
2regulation of isotype switching to IgG isotypes (GO:0048302)5.34969493
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.18907460
4response to peptidoglycan (GO:0032494)5.11663300
5negative thymic T cell selection (GO:0045060)4.90791210
6neutrophil activation involved in immune response (GO:0002283)4.73266675
7positive thymic T cell selection (GO:0045059)4.72908919
8cellular response to interleukin-15 (GO:0071350)4.56135597
9sequestering of actin monomers (GO:0042989)4.54747175
10thymic T cell selection (GO:0045061)4.50617788
11response to interleukin-15 (GO:0070672)4.47454362
12positive T cell selection (GO:0043368)4.46710878
13antigen processing and presentation of endogenous antigen (GO:0019883)4.46193172
14negative regulation of interleukin-12 production (GO:0032695)4.44415327
15positive regulation of gamma-delta T cell activation (GO:0046645)4.35758877
16T cell migration (GO:0072678)4.33280979
17negative regulation of erythrocyte differentiation (GO:0045647)4.32451306
18toxin transport (GO:1901998)4.26791289
19muscle filament sliding (GO:0030049)4.21920514
20actin-myosin filament sliding (GO:0033275)4.21920514
21modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.16852965
22modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.16852965
23positive regulation by organism of defense response of other organism involved in symbiotic interact4.16852965
24modulation by symbiont of host immune response (GO:0052553)4.16852965
25positive regulation by symbiont of host defense response (GO:0052509)4.16852965
26modulation by symbiont of host defense response (GO:0052031)4.16852965
27detection of other organism (GO:0098543)4.13863654
28positive regulation of B cell differentiation (GO:0045579)4.13444642
29negative regulation of potassium ion transmembrane transport (GO:1901380)4.09424529
30detection of bacterium (GO:0016045)4.06610675
31cellular extravasation (GO:0045123)4.06325210
32macrophage activation involved in immune response (GO:0002281)4.05085523
33regulation of mast cell degranulation (GO:0043304)4.04948805
34positive regulation of isotype switching (GO:0045830)3.99753776
35regulation of gamma-delta T cell differentiation (GO:0045586)3.97922658
36T cell selection (GO:0045058)3.89636925
37negative regulation of cell killing (GO:0031342)3.88798730
38negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.88798730
39immunoglobulin mediated immune response (GO:0016064)3.79875394
40regulation of mast cell activation involved in immune response (GO:0033006)3.68220563
41regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.67173215
42positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.61748146
43detection of external biotic stimulus (GO:0098581)3.61065331
44respiratory burst (GO:0045730)3.52463145
45regulation of myeloid leukocyte mediated immunity (GO:0002886)3.50639796
46interferon-gamma production (GO:0032609)3.50557945
47regulation of B cell differentiation (GO:0045577)3.49558789
48T cell receptor signaling pathway (GO:0050852)3.49294088
49positive regulation of DNA recombination (GO:0045911)3.47812200
50neutrophil activation (GO:0042119)3.46530067
51regulation of gamma-delta T cell activation (GO:0046643)3.43611252
52actin-mediated cell contraction (GO:0070252)3.42647225
53mitotic chromosome condensation (GO:0007076)3.38586422
54regulation of mast cell activation (GO:0033003)3.37959355
55regulation of leukocyte degranulation (GO:0043300)3.37227514
56myeloid cell activation involved in immune response (GO:0002275)3.35919748
57detection of molecule of bacterial origin (GO:0032490)3.35457498
58DNA replication checkpoint (GO:0000076)3.34165994
59positive regulation of mast cell activation (GO:0033005)3.33610151
60mitotic metaphase plate congression (GO:0007080)3.31317949
61regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.29778709
62leukocyte aggregation (GO:0070486)3.29294374
63granulocyte activation (GO:0036230)3.28427809
64negative regulation of lymphocyte mediated immunity (GO:0002707)3.25631973
65establishment of chromosome localization (GO:0051303)3.19611845
66regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.19492510
67regulation of transforming growth factor beta2 production (GO:0032909)3.18235739
68T cell costimulation (GO:0031295)3.18133012
69neutrophil mediated immunity (GO:0002446)3.16714280
70positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.14067235
71detection of biotic stimulus (GO:0009595)3.12683374
72regulation of response to interferon-gamma (GO:0060330)3.12537962
73negative regulation of leukocyte mediated immunity (GO:0002704)3.12095304
74lymphocyte costimulation (GO:0031294)3.11124841
75positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.10303814
76protein localization to kinetochore (GO:0034501)3.09483010
77response to muramyl dipeptide (GO:0032495)3.08793678
78macrophage activation (GO:0042116)3.07357927
79negative regulation of sodium ion transport (GO:0010766)3.07240871
80response to host immune response (GO:0052572)3.06909481
81response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.06909481
82ribosomal small subunit assembly (GO:0000028)3.05834056
83estrogen biosynthetic process (GO:0006703)3.05248891
84germinal center formation (GO:0002467)3.04178262
85microglial cell activation (GO:0001774)3.03222839
86B cell receptor signaling pathway (GO:0050853)3.02930174
87negative regulation of phagocytosis (GO:0050765)3.02671247
88positive regulation of immunoglobulin mediated immune response (GO:0002891)3.01426305
89positive regulation of B cell mediated immunity (GO:0002714)3.01426305
90regulation of telomere maintenance via telomerase (GO:0032210)2.99384397
91regulation of B cell receptor signaling pathway (GO:0050855)2.97682005
92regulation of interleukin-12 biosynthetic process (GO:0045075)2.97129326
93regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.96614100
94positive regulation of mast cell degranulation (GO:0043306)2.96598964
95positive regulation of mast cell activation involved in immune response (GO:0033008)2.96598964
96positive regulation of humoral immune response (GO:0002922)2.96417180
97positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.95895781
98positive regulation of natural killer cell mediated immunity (GO:0002717)2.95895781
99Arp2/3 complex-mediated actin nucleation (GO:0034314)2.94614799
100leukocyte degranulation (GO:0043299)2.93894213
101regulation of regulated secretory pathway (GO:1903305)2.93374234
102regulation of antigen processing and presentation (GO:0002577)2.91881619
103maturation of SSU-rRNA (GO:0030490)2.91166732
104DNA replication initiation (GO:0006270)2.90937873
105regulation of isotype switching (GO:0045191)2.90648791
106negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.90421010
107mitotic nuclear envelope disassembly (GO:0007077)2.90308730
108CENP-A containing nucleosome assembly (GO:0034080)2.90300058
109protein localization to chromosome, centromeric region (GO:0071459)2.90228967
110sarcomere organization (GO:0045214)2.90092959
111positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.89960690
112chromatin remodeling at centromere (GO:0031055)2.89732128
113regulation of tolerance induction (GO:0002643)2.88760178
114leukocyte migration involved in inflammatory response (GO:0002523)2.87118029
115folic acid-containing compound biosynthetic process (GO:0009396)2.86788846
116regulation of T-helper 2 cell differentiation (GO:0045628)2.86661737
117regulation of chromatin binding (GO:0035561)2.86422858
118regulation of tight junction assembly (GO:2000810)2.85369274
119regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.82577002
120regulation of natural killer cell mediated immunity (GO:0002715)2.82577002
121attachment of spindle microtubules to kinetochore (GO:0008608)2.82073586
122chaperone-mediated protein transport (GO:0072321)2.81530591
123antigen receptor-mediated signaling pathway (GO:0050851)2.80215085
124metaphase plate congression (GO:0051310)2.79989523
125regulation of T cell tolerance induction (GO:0002664)2.79463957
126B cell mediated immunity (GO:0019724)2.78816502
127definitive hemopoiesis (GO:0060216)2.77989842
128negative regulation of granulocyte differentiation (GO:0030853)2.77531709
129meiotic cell cycle (GO:0051321)2.77295520
130regulation of interferon-beta biosynthetic process (GO:0045357)2.76836943
131response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.76613220
132response to host (GO:0075136)2.76613220
133response to host defenses (GO:0052200)2.76613220
134negative regulation of T cell mediated immunity (GO:0002710)2.76344309
135myeloid dendritic cell activation (GO:0001773)2.75874100
136pentose-phosphate shunt (GO:0006098)2.75319624
137negative regulation of cytokine production involved in immune response (GO:0002719)2.75014898
138regulation of alpha-beta T cell proliferation (GO:0046640)2.74838931
139positive regulation of lamellipodium assembly (GO:0010592)2.74324397
140regulation of histone H3-K27 methylation (GO:0061085)2.73876238
141negative regulation of innate immune response (GO:0045824)2.73486689
142interferon-gamma-mediated signaling pathway (GO:0060333)2.73138916
143IMP metabolic process (GO:0046040)2.72195381
144tolerance induction (GO:0002507)2.70832542
145activation of MAPKKK activity (GO:0000185)2.70725857
146positive regulation of antigen processing and presentation (GO:0002579)2.70581396
147histone H2A ubiquitination (GO:0033522)2.70119490
148actin filament-based movement (GO:0030048)2.70053784
149megakaryocyte development (GO:0035855)2.68434414
150membrane disassembly (GO:0030397)2.68321553
151nuclear envelope disassembly (GO:0051081)2.68321553
152antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.67853025
153antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.67853025
154negative regulation of meiosis (GO:0045835)2.67585454
155activated T cell proliferation (GO:0050798)2.66327139
156regulation of immunoglobulin mediated immune response (GO:0002889)2.65676285
157regulation of helicase activity (GO:0051095)2.64479214
158piRNA metabolic process (GO:0034587)2.63305687
159positive regulation of alpha-beta T cell proliferation (GO:0046641)2.63270250
160DNA strand elongation involved in DNA replication (GO:0006271)2.62756882
161regulation of T cell receptor signaling pathway (GO:0050856)2.57883416
162skeletal muscle contraction (GO:0003009)2.56917353
163positive regulation of cell killing (GO:0031343)2.53867685
164regulation of B cell mediated immunity (GO:0002712)2.53219918
165nodal signaling pathway (GO:0038092)2.52170508
166protein localization to chromosome (GO:0034502)2.51749045
167DNA unwinding involved in DNA replication (GO:0006268)2.51658363
168DNA strand elongation (GO:0022616)2.50538631
169positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.49784823
170DNA replication-independent nucleosome organization (GO:0034724)2.48927513
171DNA replication-independent nucleosome assembly (GO:0006336)2.48927513
172microtubule severing (GO:0051013)2.44706374
173negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.41264032
174histone exchange (GO:0043486)2.40016944
175regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.39791321
176positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.39367560
177histone H2A monoubiquitination (GO:0035518)2.39148524
178heterotypic cell-cell adhesion (GO:0034113)2.38807023
179IMP biosynthetic process (GO:0006188)2.38585660

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.36492156
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.25086316
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.13197459
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.27028537
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.06343918
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.92035345
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.91462509
8MYC_22102868_ChIP-Seq_BL_Human2.90647486
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.90612576
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.86338790
11GATA1_22025678_ChIP-Seq_K562_Human2.77458945
12SCL_19346495_ChIP-Seq_HPC-7_Human2.76241773
13* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.71185476
14VDR_24763502_ChIP-Seq_THP-1_Human2.69628216
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.66449410
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.62606872
17* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.52212001
18IRF8_27001747_Chip-Seq_BMDM_Mouse2.48561314
19NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.39804163
20KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.25496842
21SPI1_23127762_ChIP-Seq_K562_Human2.19119478
22MYC_19079543_ChIP-ChIP_MESCs_Mouse2.16474915
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.10847275
24BRD4_27068464_Chip-Seq_AML-cells_Mouse2.08284455
25GABP_17652178_ChIP-ChIP_JURKAT_Human2.08075497
26* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.95392561
27EST1_17652178_ChIP-ChIP_JURKAT_Human1.91535811
28LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.91257314
29JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.90806706
30MYC_19030024_ChIP-ChIP_MESCs_Mouse1.90774568
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.90271549
32* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.89750667
33MYB_26560356_Chip-Seq_TH2_Human1.87157507
34* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.86585969
35LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.86147864
36MAF_26560356_Chip-Seq_TH1_Human1.82207941
37UTX_26944678_Chip-Seq_JUKART_Human1.81151109
38ETS1_20019798_ChIP-Seq_JURKAT_Human1.81036348
39VDR_23849224_ChIP-Seq_CD4+_Human1.78443489
40CREB1_15753290_ChIP-ChIP_HEK293T_Human1.76682140
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.74427785
42* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.73691215
43* LXR_22292898_ChIP-Seq_THP-1_Human1.71900158
44MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.71436234
45CIITA_25753668_ChIP-Seq_RAJI_Human1.67892072
46* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.65689223
47EGR1_19374776_ChIP-ChIP_THP-1_Human1.65168685
48ELF1_17652178_ChIP-ChIP_JURKAT_Human1.61322582
49NANOG_18555785_ChIP-Seq_MESCs_Mouse1.60155742
50MYB_26560356_Chip-Seq_TH1_Human1.59809778
51CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.58506393
52ELK3_25401928_ChIP-Seq_HUVEC_Human1.58348886
53FOXP3_21729870_ChIP-Seq_TREG_Human1.58003953
54IKZF1_21737484_ChIP-ChIP_HCT116_Human1.54475899
55STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.54095331
56XRN2_22483619_ChIP-Seq_HELA_Human1.52468694
57BP1_19119308_ChIP-ChIP_Hs578T_Human1.51250301
58BCL6_27268052_Chip-Seq_Bcells_Human1.48970605
59SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.48857606
60THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.47342106
61AR_21909140_ChIP-Seq_LNCAP_Human1.46542463
62GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.45959679
63VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.45085898
64MAF_26560356_Chip-Seq_TH2_Human1.44323620
65FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.43433232
66GATA1_19941827_ChIP-Seq_MEL_Mouse1.42667135
67GATA2_22383799_ChIP-Seq_G1ME_Mouse1.42022943
68E2F1_21310950_ChIP-Seq_MCF-7_Human1.40862144
69IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.40639717
70VDR_21846776_ChIP-Seq_THP-1_Human1.39091537
71BCOR_27268052_Chip-Seq_Bcells_Human1.38193238
72VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.38088288
73ELF1_20517297_ChIP-Seq_JURKAT_Human1.37171595
74RUNX_20019798_ChIP-Seq_JUKART_Human1.37096588
75Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.34994167
76IRF8_22096565_ChIP-ChIP_GC-B_Human1.34644192
77GATA1_22383799_ChIP-Seq_G1ME_Mouse1.34168172
78* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.33464923
79TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.31304155
80GABP_19822575_ChIP-Seq_HepG2_Human1.31250373
81SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.28981550
82PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28869853
83TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.27038337
84NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.26959417
85DCP1A_22483619_ChIP-Seq_HELA_Human1.26745535
86* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26658852
87* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.25949879
88PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24729167
89YY1_22570637_ChIP-Seq_MALME-3M_Human1.24480048
90CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23922399
91SPI1_23547873_ChIP-Seq_NB4_Human1.22403358
92GATA3_27048872_Chip-Seq_THYMUS_Human1.21487771
93STAT3_1855785_ChIP-Seq_MESCs_Mouse1.21050847
94RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.20160216
95TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18459514
96CTCF_27219007_Chip-Seq_ERYTHROID_Human1.18261058
97* NCOR1_26117541_ChIP-Seq_K562_Human1.17666212
98POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.16988745
99GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15888897
100MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.15240303
101KDM5A_27292631_Chip-Seq_BREAST_Human1.14580850
102FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.14531899
103CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12996265
104RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.12476846
105KDM2B_26808549_Chip-Seq_JURKAT_Human1.11596905
106P68_20966046_ChIP-Seq_HELA_Human1.11300578
107* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11087662
108SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.10634351
109HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.10498640
110SA1_27219007_Chip-Seq_ERYTHROID_Human1.09789384
111MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.09191434
112E2F1_20622854_ChIP-Seq_HELA_Human1.08814989
113SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08143060
114TTF2_22483619_ChIP-Seq_HELA_Human1.07232628
115SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06483239
116* GATA1_19941826_ChIP-Seq_K562_Human1.06378444
117PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06092250
118MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.06042675
119TCF7_22412390_ChIP-Seq_EML_Mouse1.05347948
120VDR_24787735_ChIP-Seq_THP-1_Human1.05281533
121POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.04545344
122* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.04168582
123BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04098233
124CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04092024
125KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.04037940
126CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03581559
127ELK1_19687146_ChIP-ChIP_HELA_Human1.03571636
128SPI1_20517297_ChIP-Seq_HL60_Human1.02504892
129SMAD_19615063_ChIP-ChIP_OVARY_Human1.02371500
130PU_27001747_Chip-Seq_BMDM_Mouse1.02329063
131NOTCH1_21737748_ChIP-Seq_TLL_Human1.01646677
132RARG_19884340_ChIP-ChIP_MEFs_Mouse1.01358173
133ERG_20887958_ChIP-Seq_HPC-7_Mouse1.00452314
134* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99279802
135HOXB4_20404135_ChIP-ChIP_EML_Mouse0.99002192
136KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.98785039
137* RUNX1_22412390_ChIP-Seq_EML_Mouse0.98703649
138GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98426536
139RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97726908
140RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.97453960
141MYC_18940864_ChIP-ChIP_HL60_Human0.97295375
142NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.96441416
143ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.96334374
144THAP11_20581084_ChIP-Seq_MESCs_Mouse0.94144401
145ATF3_27146783_Chip-Seq_COLON_Human0.92142688
146DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.92054618
147PU.1_20513432_ChIP-Seq_Bcells_Mouse0.91037574
148NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.90494293
149* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.90231926
150YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.89712440
151MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.89574888
152SRF_21415370_ChIP-Seq_HL-1_Mouse0.87783539
153KDM2B_26808549_Chip-Seq_DND41_Human0.87515815
154MYB_21317192_ChIP-Seq_ERMYB_Mouse0.86230782
155CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85602869
156CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.84908440
157* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.84549533
158HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.84318533

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology4.70799377
2MP0003724_increased_susceptibility_to3.79448814
3MP0005671_abnormal_response_to3.73339281
4MP0003436_decreased_susceptibility_to3.69600987
5MP0003646_muscle_fatigue3.67353507
6MP0003693_abnormal_embryo_hatching3.55257973
7MP0000465_gastrointestinal_hemorrhage3.24086060
8MP0004957_abnormal_blastocyst_morpholog3.07498169
9MP0001873_stomach_inflammation3.03202020
10MP0003303_peritoneal_inflammation2.96930725
11MP0002419_abnormal_innate_immunity2.93145703
12MP0009278_abnormal_bone_marrow2.73116631
13MP0009333_abnormal_splenocyte_physiolog2.50469551
14MP0010094_abnormal_chromosome_stability2.47230810
15MP0002148_abnormal_hypersensitivity_rea2.39784162
16MP0003111_abnormal_nucleus_morphology2.38536318
17MP0005464_abnormal_platelet_physiology2.32812656
18MP0000749_muscle_degeneration2.31506709
19MP0003077_abnormal_cell_cycle2.30226656
20MP0005058_abnormal_lysosome_morphology2.29695592
21MP0004145_abnormal_muscle_electrophysio2.28595526
22MP0003191_abnormal_cellular_cholesterol2.24704463
23MP0010352_gastrointestinal_tract_polyps2.21102643
24MP0004084_abnormal_cardiac_muscle2.15983520
25MP0000703_abnormal_thymus_morphology2.14608155
26MP0005397_hematopoietic_system_phenotyp2.11306038
27MP0001545_abnormal_hematopoietic_system2.11306038
28MP0005451_abnormal_body_composition2.03325737
29MP0004036_abnormal_muscle_relaxation2.00897899
30MP0000685_abnormal_immune_system1.96657837
31MP0003300_gastrointestinal_ulcer1.92138258
32MP0002398_abnormal_bone_marrow1.88916229
33MP0009785_altered_susceptibility_to1.83927307
34MP0000750_abnormal_muscle_regeneration1.83177775
35MP0001800_abnormal_humoral_immune1.81199090
36MP0002405_respiratory_system_inflammati1.80633331
37MP0001533_abnormal_skeleton_physiology1.78006382
38MP0002722_abnormal_immune_system1.76603780
39MP0002933_joint_inflammation1.69099192
40MP0000751_myopathy1.67860990
41MP0003075_altered_response_to1.66370475
42MP0002837_dystrophic_cardiac_calcinosis1.63617729
43MP0004130_abnormal_muscle_cell1.62020324
44MP0000689_abnormal_spleen_morphology1.61669437
45MP0003806_abnormal_nucleotide_metabolis1.59895073
46MP0002106_abnormal_muscle_physiology1.59152399
47MP0008469_abnormal_protein_level1.58573587
48MP0003718_maternal_effect1.58333693
49MP0009840_abnormal_foam_cell1.57299383
50MP0002420_abnormal_adaptive_immunity1.56948388
51MP0004087_abnormal_muscle_fiber1.52819564
52MP0001819_abnormal_immune_cell1.52603007
53MP0000716_abnormal_immune_system1.50019414
54MP0008260_abnormal_autophagy1.49620862
55MP0001835_abnormal_antigen_presentation1.48813366
56MP0003172_abnormal_lysosome_physiology1.48076725
57MP0002166_altered_tumor_susceptibility1.48063987
58MP0002723_abnormal_immune_serum1.47653661
59MP0008877_abnormal_DNA_methylation1.47458265
60MP0001730_embryonic_growth_arrest1.45552403
61MP0002269_muscular_atrophy1.43150233
62MP0005000_abnormal_immune_tolerance1.42161169
63MP0002006_tumorigenesis1.41231834
64MP0000343_altered_response_to1.39467579
65MP0006082_CNS_inflammation1.37427696
66MP0000747_muscle_weakness1.37209890
67MP0002019_abnormal_tumor_incidence1.37037402
68MP0002998_abnormal_bone_remodeling1.36245087
69MP0000858_altered_metastatic_potential1.35807577
70MP0003828_pulmonary_edema1.31705891
71MP0010155_abnormal_intestine_physiology1.30775738
72MP0002429_abnormal_blood_cell1.29710687
73MP0009764_decreased_sensitivity_to1.29619957
74MP0002452_abnormal_antigen_presenting1.28448561
75MP0005166_decreased_susceptibility_to1.26818485
76MP0003705_abnormal_hypodermis_morpholog1.26607185
77MP0004510_myositis1.24763101
78MP0001790_abnormal_immune_system1.24510945
79MP0005387_immune_system_phenotype1.24510945
80MP0003690_abnormal_glial_cell1.22780650
81MP0008932_abnormal_embryonic_tissue1.21937206
82MP0005330_cardiomyopathy1.21593904
83MP0005025_abnormal_response_to1.20429164
84MP0001851_eye_inflammation1.20180078
85MP0008057_abnormal_DNA_replication1.19851178
86MP0000350_abnormal_cell_proliferation1.16659869
87MP0003950_abnormal_plasma_membrane1.16386488
88MP0003448_altered_tumor_morphology1.16246448
89MP0008058_abnormal_DNA_repair1.15750811
90MP0010307_abnormal_tumor_latency1.15672947
91MP0003866_abnormal_defecation1.14341963
92MP0004947_skin_inflammation1.12629445
93MP0002277_abnormal_respiratory_mucosa1.11314102
94MP0000490_abnormal_crypts_of1.10365118
95MP0000759_abnormal_skeletal_muscle1.10272432
96MP0006036_abnormal_mitochondrial_physio1.08750525
97MP0005023_abnormal_wound_healing1.06050253
98MP0002396_abnormal_hematopoietic_system1.03733484
99MP0008004_abnormal_stomach_pH1.03042233
100MP0005369_muscle_phenotype1.00985527
101MP0004233_abnormal_muscle_weight0.99964093
102MP0005380_embryogenesis_phenotype0.96851571
103MP0001672_abnormal_embryogenesis/_devel0.96851571
104MP0005310_abnormal_salivary_gland0.96434331
105MP0000604_amyloidosis0.96431904
106MP0001697_abnormal_embryo_size0.94310028
107MP0005584_abnormal_enzyme/coenzyme_acti0.93587821
108MP0001853_heart_inflammation0.93175916
109MP0001845_abnormal_inflammatory_respons0.92815745
110MP0004185_abnormal_adipocyte_glucose0.91451284
111MP0010630_abnormal_cardiac_muscle0.91167258
112MP0006054_spinal_hemorrhage0.89900613
113MP0005620_abnormal_muscle_contractility0.89824740
114MP0004484_altered_response_of0.89603012
115MP0005164_abnormal_response_to0.87532007
116MP0000733_abnormal_muscle_development0.87221380
117MP0001119_abnormal_female_reproductive0.85799317
118MP0002139_abnormal_hepatobiliary_system0.85574191
119MP0003984_embryonic_growth_retardation0.85548256
120MP0004808_abnormal_hematopoietic_stem0.85369452
121MP0003221_abnormal_cardiomyocyte_apopto0.85253329
122MP0002088_abnormal_embryonic_growth/wei0.83425524
123MP0003453_abnormal_keratinocyte_physiol0.82533093
124MP0002127_abnormal_cardiovascular_syste0.81488477
125MP0003123_paternal_imprinting0.81470513
126MP0002086_abnormal_extraembryonic_tissu0.80882764
127MP0001986_abnormal_taste_sensitivity0.80856368
128MP0005385_cardiovascular_system_phenoty0.80577703
129MP0001544_abnormal_cardiovascular_syste0.80577703
130MP0002080_prenatal_lethality0.80018123
131MP0008007_abnormal_cellular_replicative0.78764159
132MP0002972_abnormal_cardiac_muscle0.78295861
133MP0003795_abnormal_bone_structure0.77942419
134MP0005390_skeleton_phenotype0.77909649
135MP0000313_abnormal_cell_death0.77608487
136MP0004215_abnormal_myocardial_fiber0.77030974
137MP0002132_abnormal_respiratory_system0.76883159
138MP0010234_abnormal_vibrissa_follicle0.76432871
139MP0001929_abnormal_gametogenesis0.76270980
140MP0002653_abnormal_ependyma_morphology0.74488904
141MP0004381_abnormal_hair_follicle0.73742444
142MP0003183_abnormal_peptide_metabolism0.72725145
143MP0004883_abnormal_blood_vessel0.72598985
144MP0005395_other_phenotype0.71093340
145MP0009763_increased_sensitivity_to0.70762011
146MP0002138_abnormal_hepatobiliary_system0.70433627
147MP0005319_abnormal_enzyme/_coenzyme0.70168827
148MP0008874_decreased_physiological_sensi0.68614115
149MP0005623_abnormal_meninges_morphology0.67793768
150MP0005645_abnormal_hypothalamus_physiol0.66867384
151MP0002332_abnormal_exercise_endurance0.61005791
152MP0000681_abnormal_thyroid_gland0.60557349
153MP0002971_abnormal_brown_adipose0.60143643
154MP0005666_abnormal_adipose_tissue0.56986731

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)6.33734033
2Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.76372145
3Nemaline bodies (HP:0003798)5.56369064
4Eczematoid dermatitis (HP:0000976)5.40248843
5T lymphocytopenia (HP:0005403)5.08480700
6Abnormality of macrophages (HP:0004311)4.89202238
7Abnormality of T cell number (HP:0011839)4.81828144
8Fatigue (HP:0012378)4.71821907
9Combined immunodeficiency (HP:0005387)4.37005711
10Type 1 muscle fiber predominance (HP:0003803)4.31739896
11Recurrent bacterial skin infections (HP:0005406)4.25311165
12Exercise-induced myalgia (HP:0003738)4.25154598
13Myositis (HP:0100614)4.24522647
14Retinal atrophy (HP:0001105)4.24241754
15Exercise-induced muscle cramps (HP:0003710)4.17100197
16Birth length less than 3rd percentile (HP:0003561)4.16023154
17Severe combined immunodeficiency (HP:0004430)4.10011639
18Obstructive lung disease (HP:0006536)3.82003781
19Chronic obstructive pulmonary disease (HP:0006510)3.82003781
20Stomatitis (HP:0010280)3.73067358
21Mediastinal lymphadenopathy (HP:0100721)3.64036097
22Thoracic kyphosis (HP:0002942)3.54899716
23Recurrent gram-negative bacterial infections (HP:0005420)3.48696309
24Calf muscle hypertrophy (HP:0008981)3.45779386
25Muscle hypertrophy of the lower extremities (HP:0008968)3.44512751
26Spontaneous hematomas (HP:0007420)3.41313709
27Abnormality of liposaccharide metabolism (HP:0010968)3.38936545
28Abnormality of glycosphingolipid metabolism (HP:0004343)3.38936545
29Abnormality of glycolipid metabolism (HP:0010969)3.38936545
30Muscle fiber splitting (HP:0003555)3.38494373
31Breast hypoplasia (HP:0003187)3.37870271
32Reduced antithrombin III activity (HP:0001976)3.28567827
33Abnormality of the lumbar spine (HP:0100712)3.25367549
34Myopathic facies (HP:0002058)3.21329664
35Abnormality of T cells (HP:0002843)3.14239648
36Facial hemangioma (HP:0000329)3.11630464
37Keratoconjunctivitis sicca (HP:0001097)3.05038571
38Ventricular tachycardia (HP:0004756)3.04962375
39Pustule (HP:0200039)3.04866553
40Meningitis (HP:0001287)3.04339748
41Vacuolated lymphocytes (HP:0001922)3.00724872
42Increased cerebral lipofuscin (HP:0011813)2.98418302
43Chest pain (HP:0100749)2.95204923
44Optic neuritis (HP:0100653)2.93853674
45Retrobulbar optic neuritis (HP:0100654)2.93853674
46Thoracolumbar scoliosis (HP:0002944)2.92883908
47Rhabdomyolysis (HP:0003201)2.91235935
48Abnormality of the columella (HP:0009929)2.89333200
49Distal arthrogryposis (HP:0005684)2.84091829
50Urticaria (HP:0001025)2.81721106
51Areflexia of lower limbs (HP:0002522)2.78795676
52Recurrent skin infections (HP:0001581)2.78149119
53Myoglobinuria (HP:0002913)2.76924505
54Abnormality of the calcaneus (HP:0008364)2.73853638
55Prolonged bleeding time (HP:0003010)2.72869835
56Vasculitis (HP:0002633)2.72631510
57Keratoconjunctivitis (HP:0001096)2.71852734
58Cellulitis (HP:0100658)2.71670262
59Increased IgE level (HP:0003212)2.69863790
60Hyporeflexia of lower limbs (HP:0002600)2.68809886
61Increased IgM level (HP:0003496)2.64817241
62Abnormality of macular pigmentation (HP:0008002)2.61299183
63Abnormal delayed hypersensitivity skin test (HP:0002963)2.60202375
64IgG deficiency (HP:0004315)2.58114120
65Ulnar deviation of the wrist (HP:0003049)2.57464613
66Increased neuronal autofluorescent lipopigment (HP:0002074)2.57443640
67Thyroiditis (HP:0100646)2.55812713
68Decreased electroretinogram (ERG) amplitude (HP:0000654)2.54958787
69EMG: myopathic abnormalities (HP:0003458)2.52489300
70Peritonitis (HP:0002586)2.52466712
71Epistaxis (HP:0000421)2.52322500
72Encephalitis (HP:0002383)2.52079670
73Orchitis (HP:0100796)2.49438929
74Chronic mucocutaneous candidiasis (HP:0002728)2.48835064
75Recurrent cutaneous fungal infections (HP:0011370)2.48835064
76Cone-rod dystrophy (HP:0000548)2.47903505
77Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.46848419
78Dyschromatopsia (HP:0007641)2.42901720
79Abolished electroretinogram (ERG) (HP:0000550)2.41018784
80Generalized hypotonia (HP:0001290)2.40976815
81Anorexia (HP:0002039)2.38782399
82Sudden death (HP:0001699)2.38630843
83Abnormality of the thoracic spine (HP:0100711)2.37485240
84Autoimmune hemolytic anemia (HP:0001890)2.36342140
85Oral leukoplakia (HP:0002745)2.36263063
86Petechiae (HP:0000967)2.35150118
87Abnormality of eosinophils (HP:0001879)2.34992255
88Gingival bleeding (HP:0000225)2.34140517
89Purpura (HP:0000979)2.31607588
90Microcytic anemia (HP:0001935)2.30665362
91Pulmonary infiltrates (HP:0002113)2.29583466
92Premature ovarian failure (HP:0008209)2.28561960
93Colon cancer (HP:0003003)2.28401525
94Inflammation of the large intestine (HP:0002037)2.27009808
95Increased connective tissue (HP:0009025)2.24707341
96Aplastic anemia (HP:0001915)2.23763163
97Calcaneovalgus deformity (HP:0001848)2.23581617
98Macular degeneration (HP:0000608)2.23231354
99Joint swelling (HP:0001386)2.22389851
100Long clavicles (HP:0000890)2.22302956
101Slow saccadic eye movements (HP:0000514)2.21327062
102Biliary tract neoplasm (HP:0100574)2.21085005
103Round ear (HP:0100830)2.19787182
104Granulocytopenia (HP:0001913)2.19211472
105Episodic fever (HP:0001954)2.19161289
106Gingivitis (HP:0000230)2.17807447
107Frequent falls (HP:0002359)2.16570299
108Hemoptysis (HP:0002105)2.15708614
109Gastrointestinal inflammation (HP:0004386)2.15284023
110Elevated erythrocyte sedimentation rate (HP:0003565)2.14847356
111Amyloidosis (HP:0011034)2.14062132
112Progressive muscle weakness (HP:0003323)2.11120004
113Difficulty running (HP:0009046)2.09510784
114Metaphyseal cupping (HP:0003021)2.09006536
115Abnormality of the calf musculature (HP:0001430)2.08288492
116Leukocytosis (HP:0001974)2.07860622
117Neck muscle weakness (HP:0000467)2.06353298
118Self-mutilation (HP:0000742)2.06125133
119Recurrent abscess formation (HP:0002722)2.04310805
120Hepatosplenomegaly (HP:0001433)2.03918634
121Dysostosis multiplex (HP:0000943)2.03525436
122Polycythemia (HP:0001901)1.99391035
123Increased serum ferritin (HP:0003281)1.99294292
124Hypochromic microcytic anemia (HP:0004840)1.98634156
125Reduced subcutaneous adipose tissue (HP:0003758)1.98470295
126Pulmonary embolism (HP:0002204)1.98375041
127Muscle stiffness (HP:0003552)1.97666655
128Increased CSF protein (HP:0002922)1.97593154
129Nasal polyposis (HP:0100582)1.96587060
130Lipoatrophy (HP:0100578)1.94852230
131Cheilitis (HP:0100825)1.93134923
132Distal lower limb muscle weakness (HP:0009053)1.93045516
133Arterial thrombosis (HP:0004420)1.92325108
134Centrally nucleated skeletal muscle fibers (HP:0003687)1.91538227
135Subaortic stenosis (HP:0001682)1.91234215
136Abnormality of the left ventricular outflow tract (HP:0011103)1.91234215
137Disinhibition (HP:0000734)1.91094452
138Abnormality of T cell physiology (HP:0011840)1.90723878
139Spondylolisthesis (HP:0003302)1.90093217
140Thrombocytosis (HP:0001894)1.88793783
141Deformed tarsal bones (HP:0008119)1.88456732
142Chromsome breakage (HP:0040012)1.88417565
14311 pairs of ribs (HP:0000878)1.88329767
144Bundle branch block (HP:0011710)1.87680732
145Hypergammaglobulinemia (HP:0010702)1.87285015
146Hypochromic anemia (HP:0001931)1.86527012
147Breech presentation (HP:0001623)1.85283586
148Asymmetric septal hypertrophy (HP:0001670)1.85131526
149Recurrent bronchitis (HP:0002837)1.84447442
150Chronic diarrhea (HP:0002028)1.84048323
151Recurrent viral infections (HP:0004429)1.83839319
152Eosinophilia (HP:0001880)1.83068498
153Multiple enchondromatosis (HP:0005701)1.79532952
154Recurrent fungal infections (HP:0002841)1.78564095
155Gastrointestinal infarctions (HP:0005244)1.75203119
156Aseptic necrosis (HP:0010885)1.75017339
157Neoplasm of the small intestine (HP:0100833)1.74847408
158Abnormality of B cell number (HP:0010975)1.74602345
159B lymphocytopenia (HP:0010976)1.74602345
160Panhypogammaglobulinemia (HP:0003139)1.74017214
161Lymphoma (HP:0002665)1.72975782
162Rimmed vacuoles (HP:0003805)1.71986428
163IgM deficiency (HP:0002850)1.71452608
164Abnormality of the fingertips (HP:0001211)1.71126099
165Malignant hyperthermia (HP:0002047)1.70955132
166Patellar aplasia (HP:0006443)1.70887587
167Cellular immunodeficiency (HP:0005374)1.70100299
168Bone marrow hypocellularity (HP:0005528)1.69335936
169Amaurosis fugax (HP:0100576)1.66513995
170Abnormal platelet volume (HP:0011876)1.65582261
171Myotonia (HP:0002486)1.64514160
172Rectal prolapse (HP:0002035)1.64231165
173Difficulty climbing stairs (HP:0003551)1.63759456
174Chromosomal breakage induced by crosslinking agents (HP:0003221)1.63114447

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN4.64684512
2TXK3.51996680
3RIPK43.41494335
4MAP4K13.21983115
5TTN3.08857314
6ERN13.01966596
7CDK82.83496852
8NME22.77241484
9TESK22.62071160
10IRAK42.55665620
11MELK2.54782721
12MAP2K62.50509683
13MAP3K112.45260663
14CDC72.44490087
15DAPK22.39645520
16STK102.37452000
17BLK2.34834249
18KDR2.13804108
19ITK2.13045771
20MST42.07446173
21ACVR1B2.06624730
22NLK2.03971162
23ZAP701.99877462
24BUB11.87977756
25FES1.86469017
26TNK21.79831648
27PKN21.74270669
28WEE11.66672674
29TTK1.62946707
30EEF2K1.61569942
31SMG11.61466235
32MAP3K71.60861136
33CLK11.49608631
34NEK21.43448940
35TAOK31.43337437
36JAK31.42356142
37CDK41.42333288
38NME11.40279976
39NEK11.38338753
40CDK91.33855898
41MAP3K141.28254177
42EPHB11.25707833
43MAP3K11.25481466
44FGR1.25072517
45GRK61.22282963
46PLK41.21451984
47LCK1.19758577
48BRSK21.16560040
49RPS6KB21.13657176
50RPS6KL11.12581113
51RPS6KC11.12581113
52TAOK21.11669751
53STK38L1.10601213
54LYN1.10156190
55JAK21.07862424
56CDK191.05489816
57PLK11.04214826
58DYRK1B1.00768770
59CSF1R1.00459889
60RPS6KA61.00325295
61HIPK20.98356287
62TESK10.94671031
63TGFBR20.94410697
64TRIB30.93895727
65STK240.93350889
66AURKB0.91742600
67PRKD20.91628079
68EIF2AK10.91077252
69BRSK10.88601449
70IKBKB0.86363307
71MUSK0.85602400
72DMPK0.84897099
73MAP3K80.84623392
74KIT0.83934324
75STK110.83712508
76PIM10.83019678
77MATK0.82718338
78CDK60.81019810
79TYK20.78094806
80EPHA20.76843622
81LRRK20.76340755
82PIK3CG0.75259829
83DAPK10.75111251
84MAP2K20.72816579
85YES10.72293705
86CSK0.71695491
87RAF10.71248371
88RPS6KA40.71009162
89MAPKAPK30.70267657
90MAPK120.69743529
91STK40.69557719
92ERBB40.69492415
93SIK20.69201072
94TAOK10.67933951
95PRKCH0.67073793
96MARK30.65399346
97TEC0.64926363
98LIMK10.63880594
99RPS6KA20.63355694
100KSR20.61399984
101AURKA0.59728770
102IKBKE0.59051989
103CAMKK20.58947337
104PTK2B0.58387324
105PRKG20.57583719
106PDK10.57148025
107JAK10.56990023
108PDPK10.56966875
109DAPK30.56266860
110IRAK20.55437428
111FGFR40.54824957
112FGFR10.54489992
113TRPM70.52815383
114FYN0.50942651
115LATS20.50298917
116CHEK10.49898506
117RIPK10.49367420
118PAK40.49164085
119SYK0.48292541
120MAPK110.48239068
121MAPK70.46556977
122BCKDK0.45877600
123TBK10.45840484
124PRPF4B0.45828699
125MARK20.44652593
126MAP2K40.44174406
127BRAF0.43917084
128TNIK0.43805588
129PDK30.43443607
130PDK40.43443607
131CHEK20.43165245
132ATR0.42994994
133BTK0.42902071
134HCK0.41457642
135GRK70.41450790
136MAP3K30.40716880
137MAP3K130.40164447
138ALK0.38853231
139PTK60.37641703
140IRAK10.37452835
141SIK30.37077542
142CAMKK10.36376222
143ATM0.36260836
144MYLK0.36052695
145PHKG20.36049205
146PHKG10.36049205
147CDK120.34834741
148RPS6KA10.34246822
149ZAK0.33598408
150MAP3K50.33351693
151MAPK100.32751323
152LATS10.32639079
153MAP3K60.32344819
154IRAK30.30598197
155PRKCQ0.30292634
156MAP2K30.29681010
157MAPK40.29400855
158CDK20.29259512
159PRKCD0.29193774

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053324.44741159
2Primary immunodeficiency_Homo sapiens_hsa053403.67943930
3Antigen processing and presentation_Homo sapiens_hsa046122.86639032
4DNA replication_Homo sapiens_hsa030302.77220428
5Staphylococcus aureus infection_Homo sapiens_hsa051502.76762959
6Proteasome_Homo sapiens_hsa030502.62863574
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.53609196
8Other glycan degradation_Homo sapiens_hsa005112.51653982
9T cell receptor signaling pathway_Homo sapiens_hsa046602.46044296
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.41913840
11RNA polymerase_Homo sapiens_hsa030202.37701497
12Mismatch repair_Homo sapiens_hsa034302.31090454
13Allograft rejection_Homo sapiens_hsa053302.25640258
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.20011255
15Tuberculosis_Homo sapiens_hsa051522.12511524
16Toll-like receptor signaling pathway_Homo sapiens_hsa046202.10982292
17Ribosome_Homo sapiens_hsa030102.05979788
18Nucleotide excision repair_Homo sapiens_hsa034202.04038690
19Cell cycle_Homo sapiens_hsa041101.99589636
20Viral myocarditis_Homo sapiens_hsa054161.91219137
21Non-homologous end-joining_Homo sapiens_hsa034501.83671212
22RNA degradation_Homo sapiens_hsa030181.81905683
23Homologous recombination_Homo sapiens_hsa034401.79097313
24RNA transport_Homo sapiens_hsa030131.73453119
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.71191646
26Base excision repair_Homo sapiens_hsa034101.70013359
27Spliceosome_Homo sapiens_hsa030401.69292027
28Basal transcription factors_Homo sapiens_hsa030221.68890319
29Lysosome_Homo sapiens_hsa041421.67809084
30Asthma_Homo sapiens_hsa053101.64618394
31Pyrimidine metabolism_Homo sapiens_hsa002401.60243019
32Malaria_Homo sapiens_hsa051441.60184391
33Measles_Homo sapiens_hsa051621.47184678
34Intestinal immune network for IgA production_Homo sapiens_hsa046721.46765995
35Rheumatoid arthritis_Homo sapiens_hsa053231.43087582
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.42181601
37Phagosome_Homo sapiens_hsa041451.38622755
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.35505669
39Chemokine signaling pathway_Homo sapiens_hsa040621.33328286
40One carbon pool by folate_Homo sapiens_hsa006701.27183834
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.26929661
42p53 signaling pathway_Homo sapiens_hsa041151.21560048
43TNF signaling pathway_Homo sapiens_hsa046681.19583999
44Hematopoietic cell lineage_Homo sapiens_hsa046401.19137939
45Leishmaniasis_Homo sapiens_hsa051401.18439180
46Glycosaminoglycan degradation_Homo sapiens_hsa005311.18073057
47Platelet activation_Homo sapiens_hsa046111.14422144
48Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.11609545
49Leukocyte transendothelial migration_Homo sapiens_hsa046701.07630869
50Legionellosis_Homo sapiens_hsa051341.06108472
51Type I diabetes mellitus_Homo sapiens_hsa049401.05294213
52Herpes simplex infection_Homo sapiens_hsa051681.04506686
53Salmonella infection_Homo sapiens_hsa051321.03857068
54HTLV-I infection_Homo sapiens_hsa051661.02730089
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.99887856
56Carbohydrate digestion and absorption_Homo sapiens_hsa049730.99470523
57Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.99362712
58Fanconi anemia pathway_Homo sapiens_hsa034600.98591108
59Biosynthesis of amino acids_Homo sapiens_hsa012300.98385615
60Cardiac muscle contraction_Homo sapiens_hsa042600.98048400
61Adherens junction_Homo sapiens_hsa045200.97971604
62Vitamin B6 metabolism_Homo sapiens_hsa007500.96826868
63Glycerophospholipid metabolism_Homo sapiens_hsa005640.94369555
64mRNA surveillance pathway_Homo sapiens_hsa030150.94145110
65Carbon metabolism_Homo sapiens_hsa012000.93369651
66Pertussis_Homo sapiens_hsa051330.93082611
67NF-kappa B signaling pathway_Homo sapiens_hsa040640.90650881
68Epstein-Barr virus infection_Homo sapiens_hsa051690.90536934
69Colorectal cancer_Homo sapiens_hsa052100.90242589
70Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.89131263
71Jak-STAT signaling pathway_Homo sapiens_hsa046300.88824148
72African trypanosomiasis_Homo sapiens_hsa051430.88822458
73Dilated cardiomyopathy_Homo sapiens_hsa054140.88072688
74Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.86351378
75Purine metabolism_Homo sapiens_hsa002300.84746433
76Pentose phosphate pathway_Homo sapiens_hsa000300.83572140
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.82239791
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.81459949
79Non-small cell lung cancer_Homo sapiens_hsa052230.79956973
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.79145683
81Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.78815024
82Parkinsons disease_Homo sapiens_hsa050120.76436226
83Ovarian steroidogenesis_Homo sapiens_hsa049130.75935432
84Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.75200952
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71769044
86Autoimmune thyroid disease_Homo sapiens_hsa053200.70741362
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69075376
88Hepatitis C_Homo sapiens_hsa051600.67380808
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66875328
90Huntingtons disease_Homo sapiens_hsa050160.66356840
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.62764415
92Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.61204528
93AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60847630
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60499437
95Pancreatic cancer_Homo sapiens_hsa052120.58791132
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58395989
97Apoptosis_Homo sapiens_hsa042100.58317290
98Fructose and mannose metabolism_Homo sapiens_hsa000510.58145551
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57542256
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.56506365
101Fatty acid elongation_Homo sapiens_hsa000620.56313204
102Bladder cancer_Homo sapiens_hsa052190.55670009
103Prolactin signaling pathway_Homo sapiens_hsa049170.55526162
104Endocytosis_Homo sapiens_hsa041440.52516387
105Viral carcinogenesis_Homo sapiens_hsa052030.52228751
106Oocyte meiosis_Homo sapiens_hsa041140.50269185
107Insulin resistance_Homo sapiens_hsa049310.49200010
108MAPK signaling pathway_Homo sapiens_hsa040100.49087324
109Oxidative phosphorylation_Homo sapiens_hsa001900.49030561
110Hepatitis B_Homo sapiens_hsa051610.48634212
111VEGF signaling pathway_Homo sapiens_hsa043700.48574033
112Shigellosis_Homo sapiens_hsa051310.48533067
113Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47426988
114Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46382798
115Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46136478
116Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45332369
117Cysteine and methionine metabolism_Homo sapiens_hsa002700.43571672
118Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43498194
119Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42791256
120Phospholipase D signaling pathway_Homo sapiens_hsa040720.41333645
121Amoebiasis_Homo sapiens_hsa051460.40960158
122RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.39897574
123Systemic lupus erythematosus_Homo sapiens_hsa053220.39179156
124Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.38618504
125Regulation of autophagy_Homo sapiens_hsa041400.38435917
126GnRH signaling pathway_Homo sapiens_hsa049120.37898785
127Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36730067
128Alzheimers disease_Homo sapiens_hsa050100.36657176
129Influenza A_Homo sapiens_hsa051640.36486888
130TGF-beta signaling pathway_Homo sapiens_hsa043500.36210450
131Thyroid cancer_Homo sapiens_hsa052160.36033805
132B cell receptor signaling pathway_Homo sapiens_hsa046620.34124271
133FoxO signaling pathway_Homo sapiens_hsa040680.33787839
134Fatty acid degradation_Homo sapiens_hsa000710.33114106
135Insulin signaling pathway_Homo sapiens_hsa049100.32326290
136Folate biosynthesis_Homo sapiens_hsa007900.31843800
137Choline metabolism in cancer_Homo sapiens_hsa052310.31591778
138Galactose metabolism_Homo sapiens_hsa000520.31124862
139Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30596187
140Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.29832208
141NOD-like receptor signaling pathway_Homo sapiens_hsa046210.28933811
142Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.28265644
143HIF-1 signaling pathway_Homo sapiens_hsa040660.27692470
144Tight junction_Homo sapiens_hsa045300.27296237
145Propanoate metabolism_Homo sapiens_hsa006400.27004843
146Osteoclast differentiation_Homo sapiens_hsa043800.26395608
147Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.25834420
148Toxoplasmosis_Homo sapiens_hsa051450.25600330
149Glucagon signaling pathway_Homo sapiens_hsa049220.25598227
150Notch signaling pathway_Homo sapiens_hsa043300.25485585
151Acute myeloid leukemia_Homo sapiens_hsa052210.24788367
152Small cell lung cancer_Homo sapiens_hsa052220.24505102
153mTOR signaling pathway_Homo sapiens_hsa041500.23191170
154Drug metabolism - other enzymes_Homo sapiens_hsa009830.23159829
155Chronic myeloid leukemia_Homo sapiens_hsa052200.21786212
156Focal adhesion_Homo sapiens_hsa045100.19644577

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