SNAP23

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues. The protein encoded by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants encoding different protein isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)4.86366642
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.74918209
3thrombin receptor signaling pathway (GO:0070493)4.30976426
4positive regulation of mast cell activation (GO:0033005)3.90759778
5production of molecular mediator involved in inflammatory response (GO:0002532)3.73889917
6antigen processing and presentation of endogenous antigen (GO:0019883)3.71540796
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.69481756
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.69481756
9positive regulation by organism of defense response of other organism involved in symbiotic interact3.69481756
10modulation by symbiont of host immune response (GO:0052553)3.69481756
11positive regulation by symbiont of host defense response (GO:0052509)3.69481756
12modulation by symbiont of host defense response (GO:0052031)3.69481756
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.68203819
14negative regulation of cell killing (GO:0031342)3.68203819
15protein neddylation (GO:0045116)3.65134900
16positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.63084326
17leukocyte migration involved in inflammatory response (GO:0002523)3.56064261
18regulation of platelet aggregation (GO:0090330)3.55311659
19positive regulation of interferon-alpha production (GO:0032727)3.52810515
20leukocyte degranulation (GO:0043299)3.46014846
21neutrophil activation (GO:0042119)3.40423258
22antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.39280657
23response to peptidoglycan (GO:0032494)3.38405971
24regulation of platelet activation (GO:0010543)3.31681581
25regulation of alpha-beta T cell proliferation (GO:0046640)3.30620053
26G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.30407501
27hepatocyte apoptotic process (GO:0097284)3.30316933
28regulation of interferon-alpha production (GO:0032647)3.30190127
29regulation of interferon-beta biosynthetic process (GO:0045357)3.28794909
30negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.24903939
31detection of bacterium (GO:0016045)3.24072013
32regulation of gamma-delta T cell activation (GO:0046643)3.23672237
33B cell receptor signaling pathway (GO:0050853)3.20648326
34dendritic cell chemotaxis (GO:0002407)3.20525499
35negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.19675455
36negative regulation of T-helper cell differentiation (GO:0045623)3.19675455
37granulocyte activation (GO:0036230)3.16927045
38antigen processing and presentation via MHC class Ib (GO:0002475)3.12720479
39regulation of regulatory T cell differentiation (GO:0045589)3.10267809
40positive regulation of mast cell degranulation (GO:0043306)3.09201908
41positive regulation of mast cell activation involved in immune response (GO:0033008)3.09201908
42positive regulation of alpha-beta T cell proliferation (GO:0046641)3.08124191
43negative regulation of thymocyte apoptotic process (GO:0070244)3.05997692
44regulation of B cell receptor signaling pathway (GO:0050855)3.03992435
45positive regulation of macrophage differentiation (GO:0045651)3.02811212
46regulation of gamma-delta T cell differentiation (GO:0045586)3.02021522
47respiratory burst (GO:0045730)2.96740988
48immunoglobulin mediated immune response (GO:0016064)2.95249051
49positive regulation of granulocyte differentiation (GO:0030854)2.95064201
50megakaryocyte development (GO:0035855)2.92472133
51negative regulation of interleukin-12 production (GO:0032695)2.89411155
52negative regulation of T cell apoptotic process (GO:0070233)2.86184741
53cytidine metabolic process (GO:0046087)2.82861025
54cytidine catabolic process (GO:0006216)2.82861025
55cytidine deamination (GO:0009972)2.82861025
56pinocytosis (GO:0006907)2.82119510
57T-helper 1 type immune response (GO:0042088)2.81505544
58interferon-gamma-mediated signaling pathway (GO:0060333)2.80217685
59superoxide anion generation (GO:0042554)2.78623577
60antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.78554482
61positive regulation of interferon-beta production (GO:0032728)2.76873039
62mast cell activation (GO:0045576)2.76481524
63regulation of RIG-I signaling pathway (GO:0039535)2.75975939
64positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.73217770
65actin nucleation (GO:0045010)2.72467079
66platelet aggregation (GO:0070527)2.71242781
67response to interferon-beta (GO:0035456)2.67212214
68negative T cell selection (GO:0043383)2.66601179
69positive regulation of immunoglobulin mediated immune response (GO:0002891)2.66208074
70positive regulation of B cell mediated immunity (GO:0002714)2.66208074
71positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.65929385
72myeloid dendritic cell activation (GO:0001773)2.65865665
73negative thymic T cell selection (GO:0045060)2.65490739
74purinergic nucleotide receptor signaling pathway (GO:0035590)2.65225439
75response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.64608589
76response to host immune response (GO:0052572)2.64608589
77histamine secretion (GO:0001821)2.64430196
78DNA deamination (GO:0045006)2.63293229
79positive regulation of isotype switching (GO:0045830)2.61885226
80positive regulation of antigen processing and presentation (GO:0002579)2.61796328
81macrophage activation involved in immune response (GO:0002281)2.60553171
82phagocytosis, engulfment (GO:0006911)2.60461229
83negative regulation of mast cell activation (GO:0033004)2.59812477
84response to interleukin-15 (GO:0070672)2.58670247
85positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.58011004
86cellular extravasation (GO:0045123)2.57993824
87regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.56827205
88autophagic vacuole fusion (GO:0000046)2.56396594
89detection of biotic stimulus (GO:0009595)2.55798989
90response to interferon-alpha (GO:0035455)2.55167858
91positive regulation of DNA recombination (GO:0045911)2.54831265
92regulation of myeloid leukocyte mediated immunity (GO:0002886)2.54228227
93positive regulation of monocyte chemotaxis (GO:0090026)2.54027022
94T cell migration (GO:0072678)2.52590859
95regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.51754021
96pyrimidine ribonucleoside catabolic process (GO:0046133)2.51725763
97regulation of MHC class II biosynthetic process (GO:0045346)2.51206539
98regulation of memory T cell differentiation (GO:0043380)2.50828202
99detection of other organism (GO:0098543)2.50425180
100positive regulation of T cell migration (GO:2000406)2.49149260
101regulation of activation of Janus kinase activity (GO:0010533)2.49121478
102regulation of mast cell activation (GO:0033003)2.49117721
103lipopolysaccharide-mediated signaling pathway (GO:0031663)2.48901593
104natural killer cell mediated immunity (GO:0002228)2.46945976
105natural killer cell mediated cytotoxicity (GO:0042267)2.46945976
106detection of molecule of bacterial origin (GO:0032490)2.46566225
107cellular response to thyroid hormone stimulus (GO:0097067)2.46231776
108positive regulation of gamma-delta T cell activation (GO:0046645)2.45865230
109leukocyte aggregation (GO:0070486)2.45850424
110myeloid dendritic cell differentiation (GO:0043011)2.45495257
111positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.45492596
112B cell mediated immunity (GO:0019724)2.44870510
113regulation of mast cell degranulation (GO:0043304)2.44785469
114regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.43133253
115regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.43133142
116regulation of antigen processing and presentation (GO:0002577)2.42547490
117response to muramyl dipeptide (GO:0032495)2.42299098
118regulation of dendritic cell antigen processing and presentation (GO:0002604)2.42129087
119regulation of mononuclear cell migration (GO:0071675)2.40303540
120negative regulation of viral genome replication (GO:0045071)2.39653908
121Arp2/3 complex-mediated actin nucleation (GO:0034314)2.38570760
122defense response to protozoan (GO:0042832)2.36983493
123myeloid cell activation involved in immune response (GO:0002275)2.36197920
124microglial cell activation (GO:0001774)2.35902735
125regulation of T cell migration (GO:2000404)2.35766026
126response to host (GO:0075136)2.34848564
127response to host defenses (GO:0052200)2.34848564
128response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.34848564
129cellular response to type I interferon (GO:0071357)2.33511627
130type I interferon signaling pathway (GO:0060337)2.33511627
131cellular response to exogenous dsRNA (GO:0071360)2.33218285
132response to type I interferon (GO:0034340)2.33164872
133positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.31815801
134positive regulation of B cell differentiation (GO:0045579)2.31173533
135regulation of mast cell activation involved in immune response (GO:0033006)2.31110070
136definitive hemopoiesis (GO:0060216)2.31070939
137positive regulation of lymphocyte migration (GO:2000403)2.30624780
138regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.29693437
139positive regulation of chemokine biosynthetic process (GO:0045080)2.29657798
140positive regulation of T cell chemotaxis (GO:0010820)2.29565316
141regulation of T cell chemotaxis (GO:0010819)2.29565316
142positive regulation of NF-kappaB import into nucleus (GO:0042346)2.29241041
143macrophage activation (GO:0042116)2.27953552
144I-kappaB kinase/NF-kappaB signaling (GO:0007249)2.27565478
145positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.26428360
146positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.25219776
147response to protozoan (GO:0001562)2.24843062
148neutrophil mediated immunity (GO:0002446)2.24235066
149myeloid leukocyte activation (GO:0002274)2.24120685
150regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.23138745
151regulation of metalloenzyme activity (GO:0048552)2.21841691
152glycosphingolipid catabolic process (GO:0046479)2.20699755
153positive regulation of interleukin-12 production (GO:0032735)2.20112751
154regulation of lymphocyte migration (GO:2000401)2.20033667
155cellular response to interferon-beta (GO:0035458)2.19311899
156regulation of B cell differentiation (GO:0045577)2.17827913
157platelet dense granule organization (GO:0060155)2.17370980
158lipoxygenase pathway (GO:0019372)2.17147641
159regulation of neutrophil migration (GO:1902622)2.15946442
160regulation of neutrophil chemotaxis (GO:0090022)2.15946442
161detection of external biotic stimulus (GO:0098581)2.15587987
162dendritic cell migration (GO:0036336)2.13521330

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.98064139
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.78922785
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.60752855
4E2F7_22180533_ChIP-Seq_HELA_Human3.43995469
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.31313827
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.23302004
7IRF8_27001747_Chip-Seq_BMDM_Mouse2.86821444
8* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.68814620
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.66384340
10SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.59847350
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.50811790
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.37571435
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.37461080
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.33064839
15Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.30667162
16* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.24776310
17* SPI1_23547873_ChIP-Seq_NB4_Human2.20165769
18SCL_19346495_ChIP-Seq_HPC-7_Human2.19720269
19SPI1_23127762_ChIP-Seq_K562_Human2.19098959
20SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.18381536
21SMAD_19615063_ChIP-ChIP_OVARY_Human1.91582940
22RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.91509946
23STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.88392927
24ELK1_19687146_ChIP-ChIP_HELA_Human1.87392701
25EGR1_19374776_ChIP-ChIP_THP-1_Human1.87292543
26STAT4_19710469_ChIP-ChIP_TH1__Mouse1.85406076
27STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.83002523
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.81061875
29FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.78985283
30* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.75855889
31HOXB4_20404135_ChIP-ChIP_EML_Mouse1.74694973
32GABP_17652178_ChIP-ChIP_JURKAT_Human1.74290918
33GATA1_22025678_ChIP-Seq_K562_Human1.74179520
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.70090557
35ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.65009673
36GATA3_27048872_Chip-Seq_THYMUS_Human1.62747222
37EST1_17652178_ChIP-ChIP_JURKAT_Human1.58845535
38NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.53398204
39NOTCH1_21737748_ChIP-Seq_TLL_Human1.53223635
40SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.52831634
41BRD4_27068464_Chip-Seq_AML-cells_Mouse1.47142841
42SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.47076718
43* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.44691319
44GATA1_19941826_ChIP-Seq_K562_Human1.44404004
45RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.43595474
46* MYB_26560356_Chip-Seq_TH2_Human1.41118499
47E2F4_17652178_ChIP-ChIP_JURKAT_Human1.40787927
48GATA2_19941826_ChIP-Seq_K562_Human1.40286788
49EGR1_23403033_ChIP-Seq_LIVER_Mouse1.39342749
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.37718889
51SRF_21415370_ChIP-Seq_HL-1_Mouse1.36939844
52ERG_20887958_ChIP-Seq_HPC-7_Mouse1.36894679
53VDR_23849224_ChIP-Seq_CD4+_Human1.35224389
54CREB1_15753290_ChIP-ChIP_HEK293T_Human1.34796816
55PU_27001747_Chip-Seq_BMDM_Mouse1.31605142
56MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.30424474
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.28258267
58GATA2_21666600_ChIP-Seq_HMVEC_Human1.25918932
59FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.24710272
60RUNX1_22412390_ChIP-Seq_EML_Mouse1.24695062
61FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.24176229
62FLI1_27457419_Chip-Seq_LIVER_Mouse1.22940511
63CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.19824672
64GATA2_22383799_ChIP-Seq_G1ME_Mouse1.18943855
65MYB_26560356_Chip-Seq_TH1_Human1.18908854
66GATA1_19941827_ChIP-Seq_MEL_Mouse1.17770822
67HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.17122080
68SALL4_22934838_ChIP-ChIP_CD34+_Human1.16716983
69TP63_19390658_ChIP-ChIP_HaCaT_Human1.16071409
70RUNX_20019798_ChIP-Seq_JUKART_Human1.15910404
71* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.15135193
72CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14847232
73MYC_18555785_ChIP-Seq_MESCs_Mouse1.14465091
74CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.13374128
75LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.13046958
76E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.12810213
77LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.11185721
78CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10917751
79PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10841265
80RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.10056295
81TFEB_21752829_ChIP-Seq_HELA_Human1.09812098
82GATA3_26560356_Chip-Seq_TH2_Human1.07964127
83SALL4_18804426_ChIP-ChIP_XEN_Mouse1.07371793
84TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06616654
85FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.05855702
86* UTX_26944678_Chip-Seq_JUKART_Human1.05151173
87VDR_24787735_ChIP-Seq_THP-1_Human1.03558928
88VDR_22108803_ChIP-Seq_LS180_Human1.02509357
89* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.02163813
90AR_21909140_ChIP-Seq_LNCAP_Human1.01820723
91CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01116325
92E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.99819900
93JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.97927151
94GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97191064
95GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95935938
96GATA3_26560356_Chip-Seq_TH1_Human0.94616546
97CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.94219654
98NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.94054072
99* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93635195
100VDR_24763502_ChIP-Seq_THP-1_Human0.92875034
101* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91981618
102E2F1_18555785_ChIP-Seq_MESCs_Mouse0.91535001
103PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91159536
104SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91088317
105CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.90134254
106MAF_26560356_Chip-Seq_TH1_Human0.90101257
107FOXM1_23109430_ChIP-Seq_U2OS_Human0.89936004
108GATA1_22383799_ChIP-Seq_G1ME_Mouse0.89699456
109CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89241060
110EZH2_27294783_Chip-Seq_NPCs_Mouse0.88998567
111* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.88163408
112PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86063874
113MYC_19030024_ChIP-ChIP_MESCs_Mouse0.86053245
114* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.85635127
115* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.85635127
116NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.85006861
117* STAT1_20625510_ChIP-Seq_HELA_Human0.84606132
118MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.84571749
119ETS1_20019798_ChIP-Seq_JURKAT_Human0.84074800
120FOXP3_21729870_ChIP-Seq_TREG_Human0.81221605
121ETS1_22383799_ChIP-Seq_G1ME_Mouse0.79651083
122CDX2_22108803_ChIP-Seq_LS180_Human0.79145329
123* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.78542115
124CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.78490053
125PCGF2_27294783_Chip-Seq_ESCs_Mouse0.78142697
126NFE2_27457419_Chip-Seq_LIVER_Mouse0.77285914
127GATA4_25053715_ChIP-Seq_YYC3_Human0.75358462
128FOXA1_21572438_ChIP-Seq_LNCaP_Human0.75297747
129* SMRT_27268052_Chip-Seq_Bcells_Human0.74907289
130SUZ12_27294783_Chip-Seq_NPCs_Mouse0.74478670
131NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.74375194
132CRX_20693478_ChIP-Seq_RETINA_Mouse0.74358710
133CEBPB_22108803_ChIP-Seq_LS180_Human0.73909442
134GATA1_19941827_ChIP-Seq_MEL86_Mouse0.73476010
135TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.72512172

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.46540685
2MP0002148_abnormal_hypersensitivity_rea2.76215842
3MP0003436_decreased_susceptibility_to2.75993681
4MP0009785_altered_susceptibility_to2.75449923
5MP0003724_increased_susceptibility_to2.70128757
6MP0002419_abnormal_innate_immunity2.43199618
7MP0006082_CNS_inflammation2.25305300
8MP0008004_abnormal_stomach_pH2.24279897
9MP0005671_abnormal_response_to2.22417004
10MP0005000_abnormal_immune_tolerance2.17612628
11MP0005025_abnormal_response_to2.12395803
12MP0003300_gastrointestinal_ulcer2.01454523
13MP0002452_abnormal_antigen_presenting2.00809749
14MP0001790_abnormal_immune_system1.85489256
15MP0005387_immune_system_phenotype1.85489256
16MP0002396_abnormal_hematopoietic_system1.83451235
17MP0001800_abnormal_humoral_immune1.80826134
18MP0002723_abnormal_immune_serum1.77391991
19MP0005058_abnormal_lysosome_morphology1.77090521
20MP0000343_altered_response_to1.76779277
21MP0000685_abnormal_immune_system1.75848412
22MP0001853_heart_inflammation1.73099972
23MP0001533_abnormal_skeleton_physiology1.72494276
24MP0005464_abnormal_platelet_physiology1.70284951
25MP0001819_abnormal_immune_cell1.68897351
26MP0002420_abnormal_adaptive_immunity1.66772989
27MP0008438_abnormal_cutaneous_collagen1.60295478
28MP0006054_spinal_hemorrhage1.60250085
29MP0002405_respiratory_system_inflammati1.57472470
30MP0009764_decreased_sensitivity_to1.53266560
31MP0001545_abnormal_hematopoietic_system1.48860691
32MP0005397_hematopoietic_system_phenotyp1.48860691
33MP0002933_joint_inflammation1.47144322
34MP0003828_pulmonary_edema1.46197896
35MP0003279_aneurysm1.43616639
36MP0002132_abnormal_respiratory_system1.43393395
37MP0003866_abnormal_defecation1.39292649
38MP0003186_abnormal_redox_activity1.38674788
39MP0009697_abnormal_copulation1.38036765
40MP0008057_abnormal_DNA_replication1.36583026
41MP0009333_abnormal_splenocyte_physiolog1.35644012
42MP0001845_abnormal_inflammatory_respons1.35217300
43MP0000465_gastrointestinal_hemorrhage1.34228732
44MP0004808_abnormal_hematopoietic_stem1.30589926
45MP0000716_abnormal_immune_system1.27696071
46MP0010155_abnormal_intestine_physiology1.26672041
47MP0003448_altered_tumor_morphology1.25960884
48MP0002398_abnormal_bone_marrow1.25686906
49MP0009278_abnormal_bone_marrow1.25664551
50MP0008469_abnormal_protein_level1.23991553
51MP0003191_abnormal_cellular_cholesterol1.23680582
52MP0005084_abnormal_gallbladder_morpholo1.20892838
53MP0004883_abnormal_blood_vessel1.19347956
54MP0005390_skeleton_phenotype1.17841878
55MP0001879_abnormal_lymphatic_vessel1.17742503
56MP0004510_myositis1.17721332
57MP0002138_abnormal_hepatobiliary_system1.16881423
58MP0000689_abnormal_spleen_morphology1.15900816
59MP0002277_abnormal_respiratory_mucosa1.15534914
60MP0000767_abnormal_smooth_muscle1.13836780
61MP0002006_tumorigenesis1.13276156
62MP0000703_abnormal_thymus_morphology1.13195410
63MP0002429_abnormal_blood_cell1.13037442
64MP0003693_abnormal_embryo_hatching1.10456240
65MP0004084_abnormal_cardiac_muscle1.07415007
66MP0002722_abnormal_immune_system1.07028208
67MP0005083_abnormal_biliary_tract1.06671743
68MP0000490_abnormal_crypts_of1.06261879
69MP0002166_altered_tumor_susceptibility1.06210554
70MP0002998_abnormal_bone_remodeling1.04625999
71MP0003252_abnormal_bile_duct1.03611104
72MP0003075_altered_response_to1.03108587
73MP0008007_abnormal_cellular_replicative1.02863759
74MP0000858_altered_metastatic_potential1.02525911
75MP0005166_decreased_susceptibility_to1.00568965
76MP0004947_skin_inflammation1.00090011
77MP0001663_abnormal_digestive_system0.99498414
78MP0004782_abnormal_surfactant_physiolog0.98731198
79MP0003183_abnormal_peptide_metabolism0.97990244
80MP0000015_abnormal_ear_pigmentation0.96433893
81MP0001851_eye_inflammation0.95963949
82MP0003950_abnormal_plasma_membrane0.95842444
83MP0003566_abnormal_cell_adhesion0.95738734
84MP0005023_abnormal_wound_healing0.93991157
85MP0003656_abnormal_erythrocyte_physiolo0.93590581
86MP0005085_abnormal_gallbladder_physiolo0.93059541
87MP0005165_increased_susceptibility_to0.92788514
88MP0010368_abnormal_lymphatic_system0.90324098
89MP0003077_abnormal_cell_cycle0.90135299
90MP0005075_abnormal_melanosome_morpholog0.90051830
91MP0009763_increased_sensitivity_to0.89895989
92MP0005167_abnormal_blood-brain_barrier0.88075875
93MP0008058_abnormal_DNA_repair0.87446873
94MP0005503_abnormal_tendon_morphology0.87140975
95MP0000230_abnormal_systemic_arterial0.86378199
96MP0009765_abnormal_xenobiotic_induced0.85782703
97MP0005164_abnormal_response_to0.85293492
98MP0008872_abnormal_physiological_respon0.85136618
99MP0003303_peritoneal_inflammation0.84866752
100MP0002877_abnormal_melanocyte_morpholog0.83791254
101MP0003763_abnormal_thymus_physiology0.83221357
102MP0000249_abnormal_blood_vessel0.82486328
103MP0001958_emphysema0.81699151
104MP0003795_abnormal_bone_structure0.81364132
105MP0010094_abnormal_chromosome_stability0.80235668
106MP0001915_intracranial_hemorrhage0.80014300
107MP0003718_maternal_effect0.79528984
108MP0005410_abnormal_fertilization0.79410189
109MP0003195_calcinosis0.78710009
110MP0005310_abnormal_salivary_gland0.78033900
111MP0004147_increased_porphyrin_level0.77919883
112MP0010307_abnormal_tumor_latency0.77009836
113MP0002019_abnormal_tumor_incidence0.75053595
114MP0009840_abnormal_foam_cell0.74292206
115MP0006036_abnormal_mitochondrial_physio0.73710606
116MP0003045_fibrosis0.73167769
117MP0004381_abnormal_hair_follicle0.72802727
118MP0005408_hypopigmentation0.72547758
119MP0004036_abnormal_muscle_relaxation0.72485111
120MP0005365_abnormal_bile_salt0.72461702
121MP0003943_abnormal_hepatobiliary_system0.72279175
122MP0008260_abnormal_autophagy0.71558755
123MP0003806_abnormal_nucleotide_metabolis0.71219273
124MP0004484_altered_response_of0.70910112
125MP0003638_abnormal_response/metabolism_0.70078976
126MP0001243_abnormal_dermal_layer0.68600174
127MP0010352_gastrointestinal_tract_polyps0.66213280
128MP0005174_abnormal_tail_pigmentation0.65863745
129MP0001873_stomach_inflammation0.65167729
130MP0003172_abnormal_lysosome_physiology0.63967659

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.67150222
2Recurrent bacterial skin infections (HP:0005406)5.13223754
3Abnormal platelet volume (HP:0011876)4.96125204
4Menorrhagia (HP:0000132)4.91703239
5Increased mean platelet volume (HP:0011877)4.90500492
6Eczematoid dermatitis (HP:0000976)4.51680820
7Recurrent gram-negative bacterial infections (HP:0005420)3.84094282
8Abnormality of macrophages (HP:0004311)3.61225514
9Vacuolated lymphocytes (HP:0001922)3.49900633
10Abnormal delayed hypersensitivity skin test (HP:0002963)3.49636644
11Abnormal platelet function (HP:0011869)3.37242570
12Impaired platelet aggregation (HP:0003540)3.37242570
13Autoimmune hemolytic anemia (HP:0001890)3.25757276
14Myositis (HP:0100614)3.12172398
15Recurrent skin infections (HP:0001581)3.06230496
16Orchitis (HP:0100796)3.05754277
17Petechiae (HP:0000967)3.04804349
18Conjunctival telangiectasia (HP:0000524)2.97048450
19T lymphocytopenia (HP:0005403)2.94866374
20Hyperlipoproteinemia (HP:0010980)2.87830348
21Prostate neoplasm (HP:0100787)2.87460582
22Chest pain (HP:0100749)2.82166548
23Panhypogammaglobulinemia (HP:0003139)2.77960503
24Abnormality of T cells (HP:0002843)2.76345758
25Retrobulbar optic neuritis (HP:0100654)2.75013704
26Optic neuritis (HP:0100653)2.75013704
27Gastrointestinal infarctions (HP:0005244)2.72946291
28Irregular epiphyses (HP:0010582)2.72897247
29Chronic mucocutaneous candidiasis (HP:0002728)2.72828401
30Recurrent cutaneous fungal infections (HP:0011370)2.72828401
31Increased neuronal autofluorescent lipopigment (HP:0002074)2.70562825
32Systemic lupus erythematosus (HP:0002725)2.67389847
33Hemoptysis (HP:0002105)2.56995809
34Gingivitis (HP:0000230)2.54366264
35Pulmonary embolism (HP:0002204)2.53826312
36Abnormality of T cell physiology (HP:0011840)2.53328971
37Mediastinal lymphadenopathy (HP:0100721)2.52846470
38Anorexia (HP:0002039)2.52524074
39Spontaneous hematomas (HP:0007420)2.51096587
40Osteolytic defects of the hand bones (HP:0009699)2.50563219
41Osteolytic defects of the phalanges of the hand (HP:0009771)2.50563219
42Recurrent pneumonia (HP:0006532)2.48845658
43Chronic obstructive pulmonary disease (HP:0006510)2.48237280
44Obstructive lung disease (HP:0006536)2.48237280
45Thick nail (HP:0001805)2.46120860
46Dyschromatopsia (HP:0007641)2.46047124
47Epiphyseal dysplasia (HP:0002656)2.45552419
48Abnormality of the heme biosynthetic pathway (HP:0010472)2.44772545
49Poikilocytosis (HP:0004447)2.44584625
50Recurrent fungal infections (HP:0002841)2.42569687
51Agammaglobulinemia (HP:0004432)2.40073596
52Elevated erythrocyte sedimentation rate (HP:0003565)2.39990420
53Poor head control (HP:0002421)2.37620815
54Thrombophlebitis (HP:0004418)2.36478695
55Chronic diarrhea (HP:0002028)2.36320849
56Acanthocytosis (HP:0001927)2.35783386
57Hepatosplenomegaly (HP:0001433)2.34154615
58Autoimmune thrombocytopenia (HP:0001973)2.30568158
59Increased cerebral lipofuscin (HP:0011813)2.29779680
60Joint swelling (HP:0001386)2.29068813
61Agnosia (HP:0010524)2.28062698
62Pustule (HP:0200039)2.24979027
63Periodontitis (HP:0000704)2.24185537
64Gingival bleeding (HP:0000225)2.22676719
65Hematochezia (HP:0002573)2.21889722
66Mucosal telangiectasiae (HP:0100579)2.21777288
67Flat capital femoral epiphysis (HP:0003370)2.21612959
68Amaurosis fugax (HP:0100576)2.21308891
69Leukocytosis (HP:0001974)2.20045286
70Abnormality of iron homeostasis (HP:0011031)2.19591516
71Basal ganglia calcification (HP:0002135)2.18630802
72Recurrent viral infections (HP:0004429)2.18410687
73Inflammation of the large intestine (HP:0002037)2.18176669
74Hypergammaglobulinemia (HP:0010702)2.17097210
75Prolonged bleeding time (HP:0003010)2.16790131
76Abnormality of the prostate (HP:0008775)2.16470853
77Acute hepatic failure (HP:0006554)2.12773106
78Bruising susceptibility (HP:0000978)2.10462534
79Abnormality of the common coagulation pathway (HP:0010990)2.10454488
80IgG deficiency (HP:0004315)2.10348381
81Patchy hypopigmentation of hair (HP:0011365)2.10272381
82Purpura (HP:0000979)2.09994606
83Myocardial infarction (HP:0001658)2.08697470
84Urticaria (HP:0001025)2.08334563
85Stomatitis (HP:0010280)2.08333322
86Recurrent lower respiratory tract infections (HP:0002783)2.08077729
87Gangrene (HP:0100758)2.07511993
88Abnormal pupillary function (HP:0007686)2.07401006
89Reduced antithrombin III activity (HP:0001976)2.06996807
90Paralysis (HP:0003470)2.06746516
91Cellulitis (HP:0100658)2.06422914
92Episodic fever (HP:0001954)2.06135882
93Epistaxis (HP:0000421)2.05415174
94Polyneuropathy (HP:0001271)2.03178810
95Vasculitis (HP:0002633)2.03174767
96Spinal cord lesions (HP:0100561)2.02607655
97Syringomyelia (HP:0003396)2.02607655
98Nausea (HP:0002018)2.01439007
99Abnormality of transition element cation homeostasis (HP:0011030)2.00989647
100Microcytic anemia (HP:0001935)2.00522912
101Vitreoretinal degeneration (HP:0000655)1.98865839
102Tinnitus (HP:0000360)1.98593698
103Thrombocytosis (HP:0001894)1.96026763
104IgM deficiency (HP:0002850)1.95064190
105Cupped ribs (HP:0000887)1.95062544
106Pulmonary fibrosis (HP:0002206)1.93532406
107Gastrointestinal inflammation (HP:0004386)1.93303448
108Small epiphyses (HP:0010585)1.93128304
109Vertigo (HP:0002321)1.93074106
110Osteomyelitis (HP:0002754)1.92298372
111Glomerulonephritis (HP:0000099)1.90848208
112Increased serum ferritin (HP:0003281)1.90381465
113Skin rash (HP:0000988)1.89764332
114White forelock (HP:0002211)1.88937054
115Spondylolisthesis (HP:0003302)1.87748644
116Granulocytopenia (HP:0001913)1.87017939
117Polycythemia (HP:0001901)1.86889780
118Eosinophilia (HP:0001880)1.86729996
119Prolonged neonatal jaundice (HP:0006579)1.85902953
120Abnormality of cells of the lymphoid lineage (HP:0012140)1.85887580
121Beaking of vertebral bodies (HP:0004568)1.84862728
122Keratoconjunctivitis sicca (HP:0001097)1.81795875
123Cervical subluxation (HP:0003308)1.81362574
124Metaphyseal dysplasia (HP:0100255)1.80813509
125Birth length less than 3rd percentile (HP:0003561)1.78234618
126Increased IgM level (HP:0003496)1.77945682
127Vertebral compression fractures (HP:0002953)1.77762643
128Arterial thrombosis (HP:0004420)1.77297059
129Congenital, generalized hypertrichosis (HP:0004540)1.77111028
130Short middle phalanx of the 5th finger (HP:0004220)1.76736502
131Meningitis (HP:0001287)1.73918839
132Pulmonary infiltrates (HP:0002113)1.73915391
133Hypoplastic ischia (HP:0003175)1.73507715
134Acute myeloid leukemia (HP:0004808)1.73343648
135Encephalitis (HP:0002383)1.72138685
136Abnormality of T cell number (HP:0011839)1.71990504
137Abnormality of the lumbar spine (HP:0100712)1.71721478
138Abnormality of eosinophils (HP:0001879)1.71549136
139Abnormality of the vasculature of the conjunctiva (HP:0008054)1.71501249
140Abnormality of incisor morphology (HP:0011063)1.70011547
141Chronic otitis media (HP:0000389)1.69579754
142Axonal loss (HP:0003447)1.69259266
143Abnormal foot bone ossification (HP:0010675)1.69097032
144Chromsome breakage (HP:0040012)1.68215995
145Nonimmune hydrops fetalis (HP:0001790)1.67390274
146Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.66284230
147Joint hemorrhage (HP:0005261)1.65091386
148Interstitial pulmonary disease (HP:0006530)1.63668690
149Keratoconjunctivitis (HP:0001096)1.63043449
150Disinhibition (HP:0000734)1.62913435
151Anhidrosis (HP:0000970)1.62546887
152Abnormality of glycosphingolipid metabolism (HP:0004343)1.61990997

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK42.86976540
2MAP3K142.61973850
3NEK92.46273062
4IRAK32.40825322
5BLK2.39106096
6FES2.27331403
7TXK2.12365379
8PBK2.10763163
9TGFBR21.99182482
10NME21.87456555
11TEC1.86271620
12PIM21.84434786
13KIT1.77999051
14TIE11.77278462
15FGR1.76022042
16TYK21.74043673
17GRK61.73445432
18NUAK11.72146269
19TBK11.71382726
20MAP4K11.66776681
21RPS6KA41.66062425
22MAP2K31.61656253
23JAK31.61563166
24* IKBKB1.61365809
25TRPM71.58111171
26BTK1.54123974
27ZAK1.54050113
28MKNK11.53422761
29LMTK21.52460142
30STK161.52295068
31MAP3K31.51991992
32ACVR1B1.49543737
33TGFBR11.48432799
34KDR1.48051505
35BMPR1B1.47717359
36MST41.42110770
37EIF2AK11.40851279
38IKBKE1.40287627
39PTK2B1.38591750
40MAP3K121.36732800
41BUB11.36144489
42STK31.35542034
43STK101.35191519
44MUSK1.32178247
45CSF1R1.31785655
46BRSK21.29393567
47TAOK31.23275619
48EIF2AK31.21657849
49STK41.20782955
50PIM11.19003961
51ZAP701.16952906
52EIF2AK21.14669222
53BMX1.14314246
54PLK41.13619419
55ERBB31.10735458
56NLK1.09914629
57PRKCQ1.07196315
58SIK31.06914336
59TNK21.06388525
60CHUK1.05525800
61LYN0.99869159
62CSK0.96403115
63SRPK10.93558766
64NEK60.90375848
65EPHB10.89760277
66ERN10.88119020
67VRK10.84954902
68JAK10.84436120
69LATS10.82952454
70GRK50.80290706
71WEE10.76510923
72CLK10.76172625
73ADRBK20.75203330
74STK240.74667949
75ITK0.73755321
76MKNK20.73589915
77ABL20.71803883
78LCK0.70598045
79IRAK10.70426419
80EPHA30.69969883
81ILK0.69788278
82PIK3CA0.69509102
83PIK3CG0.68268509
84HCK0.66638323
85RPS6KA50.66441344
86TESK20.66021763
87MATK0.64623802
88TRIM280.64416085
89YES10.63242659
90GRK10.62817595
91FRK0.62676916
92FER0.62648619
93SYK0.62362999
94CDK60.60041094
95DYRK30.59613834
96MYLK0.59255180
97MAP3K50.59200242
98FLT30.58403829
99ABL10.57275095
100ATR0.57032696
101MAP3K130.56589501
102PDK10.55814870
103PAK10.54693531
104PAK40.54089813
105CDK70.53658796
106MAPKAPK50.52878754
107MAPKAPK30.52098622
108AURKB0.51195748
109BMPR20.50413555
110MARK30.50393419
111OXSR10.49103308
112FGFR30.48940147
113PDK20.47392809
114MAPKAPK20.45631538
115LRRK20.45044891
116ADRBK10.44269900
117PRKG20.42087362
118TLK10.41907588
119PRKCD0.41895561
120IGF1R0.39855422
121MAP3K10.39402823
122EGFR0.39173114
123GRK70.39164271
124RIPK40.38889915
125OBSCN0.35554310
126IRAK20.34555016
127BRD40.34544216
128JAK20.34002195
129FYN0.33705225
130PRKD10.32526877
131MAPK120.30760842
132PLK20.29415125
133MAP3K20.28420843
134PDPK10.27541379

Predicted pathways (KEGG)

RankGene SetZ-score
1Type I diabetes mellitus_Homo sapiens_hsa049402.67695876
2Staphylococcus aureus infection_Homo sapiens_hsa051502.43959129
3Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.32914784
4Leishmaniasis_Homo sapiens_hsa051402.29633257
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.12972510
6Malaria_Homo sapiens_hsa051442.07725355
7Legionellosis_Homo sapiens_hsa051341.92079333
8Other glycan degradation_Homo sapiens_hsa005111.83181407
9Graft-versus-host disease_Homo sapiens_hsa053321.82147094
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.80374951
11Allograft rejection_Homo sapiens_hsa053301.79366741
12Intestinal immune network for IgA production_Homo sapiens_hsa046721.67740007
13NOD-like receptor signaling pathway_Homo sapiens_hsa046211.63439163
14Measles_Homo sapiens_hsa051621.62461737
15Toll-like receptor signaling pathway_Homo sapiens_hsa046201.58448959
16Hematopoietic cell lineage_Homo sapiens_hsa046401.55414862
17Herpes simplex infection_Homo sapiens_hsa051681.54847071
18Asthma_Homo sapiens_hsa053101.54431256
19Proteasome_Homo sapiens_hsa030501.51322364
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.47727543
21Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.43996460
22DNA replication_Homo sapiens_hsa030301.43985328
23Lysosome_Homo sapiens_hsa041421.40702240
24Homologous recombination_Homo sapiens_hsa034401.40433141
25Pertussis_Homo sapiens_hsa051331.40397649
26Caffeine metabolism_Homo sapiens_hsa002321.39410666
27RNA polymerase_Homo sapiens_hsa030201.35602573
28Rheumatoid arthritis_Homo sapiens_hsa053231.34983915
29Osteoclast differentiation_Homo sapiens_hsa043801.33716776
30Protein export_Homo sapiens_hsa030601.33150019
31Basal transcription factors_Homo sapiens_hsa030221.28816556
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.26467545
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.25969928
34Antigen processing and presentation_Homo sapiens_hsa046121.21895352
35Base excision repair_Homo sapiens_hsa034101.18387439
36Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.17635368
37Shigellosis_Homo sapiens_hsa051311.17067315
38T cell receptor signaling pathway_Homo sapiens_hsa046601.17009665
39Influenza A_Homo sapiens_hsa051641.16541206
40Tuberculosis_Homo sapiens_hsa051521.15362522
41Arachidonic acid metabolism_Homo sapiens_hsa005901.14970947
42Non-homologous end-joining_Homo sapiens_hsa034501.14053075
43Jak-STAT signaling pathway_Homo sapiens_hsa046301.13766541
44Autoimmune thyroid disease_Homo sapiens_hsa053201.13757253
45Mismatch repair_Homo sapiens_hsa034301.12005292
46Ribosome_Homo sapiens_hsa030101.11520357
47Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.10895521
48Primary immunodeficiency_Homo sapiens_hsa053401.10446680
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.09432722
50Toxoplasmosis_Homo sapiens_hsa051451.04658869
51Steroid biosynthesis_Homo sapiens_hsa001001.03477371
52TNF signaling pathway_Homo sapiens_hsa046681.02679413
53Apoptosis_Homo sapiens_hsa042100.99731154
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.99397352
55Cell cycle_Homo sapiens_hsa041100.96270051
56Phagosome_Homo sapiens_hsa041450.96230332
57Leukocyte transendothelial migration_Homo sapiens_hsa046700.96067869
58p53 signaling pathway_Homo sapiens_hsa041150.95851839
59Complement and coagulation cascades_Homo sapiens_hsa046100.95585176
60Viral myocarditis_Homo sapiens_hsa054160.95526981
61Nucleotide excision repair_Homo sapiens_hsa034200.95283405
62Sphingolipid metabolism_Homo sapiens_hsa006000.94073996
63Collecting duct acid secretion_Homo sapiens_hsa049660.92033634
64Systemic lupus erythematosus_Homo sapiens_hsa053220.91511034
65Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.90684592
66Nitrogen metabolism_Homo sapiens_hsa009100.89760908
67Glycosaminoglycan degradation_Homo sapiens_hsa005310.88849057
68Salmonella infection_Homo sapiens_hsa051320.86505633
69Fanconi anemia pathway_Homo sapiens_hsa034600.86087403
70Sulfur metabolism_Homo sapiens_hsa009200.82709237
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.82290443
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.81789530
73B cell receptor signaling pathway_Homo sapiens_hsa046620.80755520
74Epstein-Barr virus infection_Homo sapiens_hsa051690.79855648
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79220488
76Pyrimidine metabolism_Homo sapiens_hsa002400.78584927
77Hepatitis B_Homo sapiens_hsa051610.75493991
78RNA degradation_Homo sapiens_hsa030180.75134323
79* SNARE interactions in vesicular transport_Homo sapiens_hsa041300.72402757
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71392531
81Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.71383850
82Spliceosome_Homo sapiens_hsa030400.70834642
83Folate biosynthesis_Homo sapiens_hsa007900.70471173
84RNA transport_Homo sapiens_hsa030130.69796887
85One carbon pool by folate_Homo sapiens_hsa006700.68142102
86Vitamin digestion and absorption_Homo sapiens_hsa049770.66651270
87Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66034368
88Hepatitis C_Homo sapiens_hsa051600.65783918
89ECM-receptor interaction_Homo sapiens_hsa045120.63972685
90Vitamin B6 metabolism_Homo sapiens_hsa007500.63915256
91Chemokine signaling pathway_Homo sapiens_hsa040620.61042827
92Ether lipid metabolism_Homo sapiens_hsa005650.60238001
93Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.59869723
94alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.59861347
95Small cell lung cancer_Homo sapiens_hsa052220.59735137
96Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.58912603
97* Platelet activation_Homo sapiens_hsa046110.57786382
98Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57554850
99Glutathione metabolism_Homo sapiens_hsa004800.55980527
100Viral carcinogenesis_Homo sapiens_hsa052030.54901693
101Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.53073872
102AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52463924
103Renin-angiotensin system_Homo sapiens_hsa046140.52359866
104Endocytosis_Homo sapiens_hsa041440.52161225
105Linoleic acid metabolism_Homo sapiens_hsa005910.45093226
106Acute myeloid leukemia_Homo sapiens_hsa052210.44684844
107Pentose phosphate pathway_Homo sapiens_hsa000300.42346271
108Drug metabolism - other enzymes_Homo sapiens_hsa009830.42171538
109HTLV-I infection_Homo sapiens_hsa051660.42047472
110Regulation of autophagy_Homo sapiens_hsa041400.41526283
111Starch and sucrose metabolism_Homo sapiens_hsa005000.40088472
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39747233
113Histidine metabolism_Homo sapiens_hsa003400.39458402
114African trypanosomiasis_Homo sapiens_hsa051430.38981341
115Retinol metabolism_Homo sapiens_hsa008300.38787491
116Adherens junction_Homo sapiens_hsa045200.38092887
117Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.37987854
118Fatty acid elongation_Homo sapiens_hsa000620.37162700
119Pancreatic cancer_Homo sapiens_hsa052120.35187466
120Chemical carcinogenesis_Homo sapiens_hsa052040.34897051
121Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34357949
122Fat digestion and absorption_Homo sapiens_hsa049750.30412225
123Peroxisome_Homo sapiens_hsa041460.29977451
124Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29066528
125Steroid hormone biosynthesis_Homo sapiens_hsa001400.28534015
126Galactose metabolism_Homo sapiens_hsa000520.27630620
127Glycerolipid metabolism_Homo sapiens_hsa005610.26189200
128Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.23413336
129Non-small cell lung cancer_Homo sapiens_hsa052230.23383883
130Glycerophospholipid metabolism_Homo sapiens_hsa005640.22075506
131Pancreatic secretion_Homo sapiens_hsa049720.18002901
132Vascular smooth muscle contraction_Homo sapiens_hsa042700.17874569

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