SNAP47

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine deamination (GO:0009972)6.52030834
2cytidine metabolic process (GO:0046087)6.52030834
3cytidine catabolic process (GO:0006216)6.52030834
4regulation of mitochondrial translation (GO:0070129)6.44655169
5synaptic vesicle exocytosis (GO:0016079)5.81344649
6regulation of short-term neuronal synaptic plasticity (GO:0048172)5.78425205
7pyrimidine ribonucleoside catabolic process (GO:0046133)5.59910762
8DNA deamination (GO:0045006)5.58318774
9vocalization behavior (GO:0071625)5.40047359
10glutamate secretion (GO:0014047)5.36252406
11synaptic vesicle docking involved in exocytosis (GO:0016081)5.29748351
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.19209545
13regulation of synaptic vesicle exocytosis (GO:2000300)5.19167441
14neuron cell-cell adhesion (GO:0007158)5.00321394
15positive regulation of cell size (GO:0045793)4.93610180
16positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.85743113
17regulation of glutamate receptor signaling pathway (GO:1900449)4.80944221
18synaptic vesicle maturation (GO:0016188)4.80242422
19eosinophil chemotaxis (GO:0048245)4.79129647
20negative regulation by host of viral transcription (GO:0043922)4.78764909
21protein localization to synapse (GO:0035418)4.76770672
22regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.74757029
23positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.69603759
24neurotransmitter secretion (GO:0007269)4.67647374
25regulation of synaptic vesicle transport (GO:1902803)4.61378431
26neurotransmitter-gated ion channel clustering (GO:0072578)4.60266272
27pyrimidine nucleoside salvage (GO:0043097)4.57145166
28pyrimidine-containing compound salvage (GO:0008655)4.57145166
29regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.37572872
30locomotory exploration behavior (GO:0035641)4.36080048
31neuronal action potential propagation (GO:0019227)4.35945724
32eosinophil migration (GO:0072677)4.24841963
33cellular protein complex localization (GO:0034629)4.22051703
34chaperone-mediated protein transport (GO:0072321)4.18138049
35ionotropic glutamate receptor signaling pathway (GO:0035235)4.17396731
36ncRNA 3-end processing (GO:0043628)4.16662732
37neuron-neuron synaptic transmission (GO:0007270)4.16279154
38negative regulation of synaptic transmission, GABAergic (GO:0032229)4.16248787
39synaptic transmission, glutamatergic (GO:0035249)4.06497060
40positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)3.99747962
41pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)3.95994104
42UMP metabolic process (GO:0046049)3.95994104
43pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)3.95994104
44UMP biosynthetic process (GO:0006222)3.95994104
45negative regulation of calcium ion transport into cytosol (GO:0010523)3.95603579
46gamma-aminobutyric acid signaling pathway (GO:0007214)3.86933432
47presynaptic membrane assembly (GO:0097105)3.86599517
48glutamate receptor signaling pathway (GO:0007215)3.85565663
49negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.84730932
50iron-sulfur cluster assembly (GO:0016226)3.82434077
51metallo-sulfur cluster assembly (GO:0031163)3.82434077
52postsynaptic membrane organization (GO:0001941)3.79888330
53nucleoside salvage (GO:0043174)3.79261349
54neurotransmitter transport (GO:0006836)3.78906551
55exploration behavior (GO:0035640)3.78791917
56gamma-aminobutyric acid transport (GO:0015812)3.78520717
57membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.76804834
58regulation of neuronal synaptic plasticity (GO:0048168)3.76546691
59proline transport (GO:0015824)3.73646727
60regulation of long-term neuronal synaptic plasticity (GO:0048169)3.72810202
61positive regulation of synapse maturation (GO:0090129)3.71793950
62arginine catabolic process (GO:0006527)3.68894643
63presynaptic membrane organization (GO:0097090)3.67043447
64regulation of cellular amino acid metabolic process (GO:0006521)3.65985243
65protein complex localization (GO:0031503)3.64387723
66neuron recognition (GO:0008038)3.64323517
67diaphragm development (GO:0060539)3.62832326
68ATP hydrolysis coupled proton transport (GO:0015991)3.62363607
69energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.62363607
70negative regulation of ligase activity (GO:0051352)3.62144192
71negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.62144192
72regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.61504577
73synaptic vesicle endocytosis (GO:0048488)3.58677373
74regulation of synapse structural plasticity (GO:0051823)3.55992641
75protein maturation by protein folding (GO:0022417)3.53124283
76positive regulation of interleukin-8 secretion (GO:2000484)3.52447815
77transferrin transport (GO:0033572)3.52395521
78peptidyl-arginine omega-N-methylation (GO:0035247)3.51898952
79regulation of excitatory postsynaptic membrane potential (GO:0060079)3.51594430
80regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.51315120
81regulation of neurotransmitter levels (GO:0001505)3.51307931
82pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)3.48276801
83regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.47529929
84positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.46805994
85regulation of synaptic transmission, glutamatergic (GO:0051966)3.43807993
86negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.43321515
87protein deneddylation (GO:0000338)3.42279573
88deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.41497478
89regulation of neurotransmitter secretion (GO:0046928)3.41056509
90response to histamine (GO:0034776)3.40389910
91positive regulation of membrane potential (GO:0045838)3.40082179
92regulation of postsynaptic membrane potential (GO:0060078)3.39964658
93anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.39523651
94proteasome assembly (GO:0043248)3.39497609
95nucleotide salvage (GO:0043173)3.36288420
96negative regulation of viral transcription (GO:0032897)3.36172525
97DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.32171624
98signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.30898529
99signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.30898529
100signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.30898529
101positive regulation of viral genome replication (GO:0045070)3.30680902
102positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.30397535
103ferric iron transport (GO:0015682)3.29073932
104trivalent inorganic cation transport (GO:0072512)3.29073932
105activation of protein kinase A activity (GO:0034199)3.29017172
106positive regulation of synaptic transmission, GABAergic (GO:0032230)3.28841747
107pyrimidine nucleoside monophosphate metabolic process (GO:0009129)3.28304110
108cerebellar Purkinje cell differentiation (GO:0021702)3.28079637
109CTP biosynthetic process (GO:0006241)3.27362426
110CTP metabolic process (GO:0046036)3.27362426
111layer formation in cerebral cortex (GO:0021819)3.27309249
112long-term memory (GO:0007616)3.27271759
113signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.27111262
114intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.27111262
115positive regulation of neurotransmitter transport (GO:0051590)3.26574353
116respiratory chain complex IV assembly (GO:0008535)3.25936858
117pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.25868800
118neuromuscular process controlling posture (GO:0050884)3.24805910
119* long-term synaptic potentiation (GO:0060291)3.24444939
120cerebellar granule cell differentiation (GO:0021707)3.24121604
121regulation of glutamate secretion (GO:0014048)3.23201576
122positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.22363406
123startle response (GO:0001964)3.21724223
124regulation of activation of Janus kinase activity (GO:0010533)3.21655554
125regulation of chronic inflammatory response (GO:0002676)3.21115428
126signal transduction involved in DNA damage checkpoint (GO:0072422)3.21065675
127signal transduction involved in DNA integrity checkpoint (GO:0072401)3.21065675
128positive regulation of synapse assembly (GO:0051965)3.20327549
129regulation of neurotransmitter transport (GO:0051588)3.19977147
130* regulation of synaptic plasticity (GO:0048167)3.19099233
131behavioral response to cocaine (GO:0048148)3.19056964
132pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.17663347
133signal transduction involved in cell cycle checkpoint (GO:0072395)3.17321184
134positive regulation of translational initiation (GO:0045948)3.16896558
135base-excision repair, AP site formation (GO:0006285)3.16285462
136pyrimidine ribonucleoside metabolic process (GO:0046131)3.15883877
137skeletal muscle organ development (GO:0060538)3.15205305
138regulation of nuclear cell cycle DNA replication (GO:0033262)3.14788844
139histone arginine methylation (GO:0034969)3.14618206
140cytochrome complex assembly (GO:0017004)3.14359897
141axonal fasciculation (GO:0007413)3.13358854
142regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.13073049
143positive regulation of T cell apoptotic process (GO:0070234)3.12836133
144negative regulation of dendrite morphogenesis (GO:0050774)3.12258446
145regulation of vesicle fusion (GO:0031338)3.11152625
146positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.10031737
147regulation of ubiquitin-protein transferase activity (GO:0051438)3.09972293
148adenine nucleotide transport (GO:0051503)3.09913167
149macrophage chemotaxis (GO:0048246)3.07565541
150transmission of nerve impulse (GO:0019226)3.07181214
151positive regulation of ligase activity (GO:0051351)3.06851100
152synaptic transmission (GO:0007268)3.06123795
153G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.06042625
154establishment of synaptic vesicle localization (GO:0097480)3.05570875
155synaptic vesicle transport (GO:0048489)3.05570875
156regulation of synaptic transmission, GABAergic (GO:0032228)3.05325712
157regulation of synapse maturation (GO:0090128)3.05221802
158female mating behavior (GO:0060180)3.03990764
159positive regulation of neurotransmitter secretion (GO:0001956)3.03438845
160regulation of female receptivity (GO:0045924)3.03227105
161regulation of chemokine-mediated signaling pathway (GO:0070099)3.00670073
162negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.00310120
163behavioral defense response (GO:0002209)2.99807050
164behavioral fear response (GO:0001662)2.99807050
165synapse assembly (GO:0007416)2.98496900
166striatum development (GO:0021756)2.98103757
167regulation of cellular respiration (GO:0043457)2.96817110
168establishment of protein localization to mitochondrial membrane (GO:0090151)2.96437745
169mechanosensory behavior (GO:0007638)2.96032161
170membrane depolarization (GO:0051899)2.95978285
171cullin deneddylation (GO:0010388)2.95909586
172auditory behavior (GO:0031223)2.95483516
173pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.94206905
174* regulation of synaptic transmission (GO:0050804)2.93303182
175* positive regulation of synaptic transmission (GO:0050806)2.92849483
176membrane hyperpolarization (GO:0060081)2.92822998
177pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.91645769
178arginine metabolic process (GO:0006525)2.91009925
179regulation of ligase activity (GO:0051340)2.90901270
180peptidyl-arginine N-methylation (GO:0035246)2.89940373
181peptidyl-arginine methylation (GO:0018216)2.89940373
182positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.89828917
183membrane depolarization during action potential (GO:0086010)2.89318354
184learning (GO:0007612)2.88655757
185fear response (GO:0042596)2.85504270
186dendritic spine morphogenesis (GO:0060997)2.85440630
187positive regulation of receptor biosynthetic process (GO:0010870)2.85388542
188establishment of vesicle localization (GO:0051650)2.84305742
189inactivation of MAPK activity (GO:0000188)2.82770936
190modulation by host of viral transcription (GO:0043921)2.80142673
191modulation by host of symbiont transcription (GO:0052472)2.80142673
192negative regulation of T cell apoptotic process (GO:0070233)2.75160982
193COPI coating of Golgi vesicle (GO:0048205)2.74095712
194Golgi transport vesicle coating (GO:0048200)2.74095712
195positive regulation of cell cycle arrest (GO:0071158)2.71015299
196regulation of lymphocyte chemotaxis (GO:1901623)2.69289792
197establishment of protein localization to mitochondrion (GO:0072655)2.68170346
198regulation of cholesterol biosynthetic process (GO:0045540)2.68040018
199negative regulation of T cell receptor signaling pathway (GO:0050860)2.66816063
200DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.64527841

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.48698972
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.66388584
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.55522709
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.39289960
5GBX2_23144817_ChIP-Seq_PC3_Human4.32490687
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.10633896
7E2F7_22180533_ChIP-Seq_HELA_Human4.09018432
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.08463961
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.95139380
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.26764465
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.14507508
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.98678819
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.94613199
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.92794941
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.89105474
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.83158390
17REST_21632747_ChIP-Seq_MESCs_Mouse2.82819091
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.74935096
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.70284339
20EST1_17652178_ChIP-ChIP_JURKAT_Human2.57533380
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.57515375
22MYC_18358816_ChIP-ChIP_MESCs_Mouse2.57167388
23MYC_18555785_ChIP-Seq_MESCs_Mouse2.56839455
24JARID2_20075857_ChIP-Seq_MESCs_Mouse2.55749600
25TAF15_26573619_Chip-Seq_HEK293_Human2.54302856
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.53620659
27EZH2_27304074_Chip-Seq_ESCs_Mouse2.52517349
28RNF2_18974828_ChIP-Seq_MESCs_Mouse2.51799813
29EZH2_18974828_ChIP-Seq_MESCs_Mouse2.51799813
30SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.49695674
31THAP11_20581084_ChIP-Seq_MESCs_Mouse2.47620143
32ELF1_17652178_ChIP-ChIP_JURKAT_Human2.43940057
33SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.42242606
34REST_18959480_ChIP-ChIP_MESCs_Mouse2.41369577
35SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.40844253
36MTF2_20144788_ChIP-Seq_MESCs_Mouse2.33839531
37EED_16625203_ChIP-ChIP_MESCs_Mouse2.30897090
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.29359029
39RARB_27405468_Chip-Seq_BRAIN_Mouse2.28330331
40GABP_19822575_ChIP-Seq_HepG2_Human2.28152678
41CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.27797837
42CTBP2_25329375_ChIP-Seq_LNCAP_Human2.24940537
43XRN2_22483619_ChIP-Seq_HELA_Human2.20926035
44CREB1_15753290_ChIP-ChIP_HEK293T_Human2.16194666
45SUZ12_27294783_Chip-Seq_ESCs_Mouse2.11186001
46CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.10476440
47EZH2_27294783_Chip-Seq_ESCs_Mouse2.10250276
48SRF_21415370_ChIP-Seq_HL-1_Mouse2.08553776
49MYC_19030024_ChIP-ChIP_MESCs_Mouse2.04572406
50DROSHA_22980978_ChIP-Seq_HELA_Human2.00580060
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.99911305
52TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.98118401
53RNF2_27304074_Chip-Seq_ESCs_Mouse1.96152719
54TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.95711916
55E2F1_18555785_ChIP-Seq_MESCs_Mouse1.91976238
56CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.91761517
57PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.91266149
58* FOXP3_21729870_ChIP-Seq_TREG_Human1.90658398
59ZFP57_27257070_Chip-Seq_ESCs_Mouse1.90127233
60VDR_23849224_ChIP-Seq_CD4+_Human1.89829091
61* DCP1A_22483619_ChIP-Seq_HELA_Human1.88027541
62ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.87194616
63IKZF1_21737484_ChIP-ChIP_HCT116_Human1.84245314
64SMAD4_21799915_ChIP-Seq_A2780_Human1.79885981
65KDM5A_27292631_Chip-Seq_BREAST_Human1.78497621
66NELFA_20434984_ChIP-Seq_ESCs_Mouse1.75132255
67ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.73763606
68P300_19829295_ChIP-Seq_ESCs_Human1.70600622
69YY1_21170310_ChIP-Seq_MESCs_Mouse1.70276847
70BMI1_23680149_ChIP-Seq_NPCS_Mouse1.68596884
71AR_21572438_ChIP-Seq_LNCaP_Human1.67895008
72MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.64201124
73SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.62738500
74TTF2_22483619_ChIP-Seq_HELA_Human1.59226237
75ZFX_18555785_ChIP-Seq_MESCs_Mouse1.57732972
76ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.54167959
77E2F4_17652178_ChIP-ChIP_JURKAT_Human1.53592698
78POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.52218389
79MYCN_18555785_ChIP-Seq_MESCs_Mouse1.51582669
80PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49363109
81TET1_21451524_ChIP-Seq_MESCs_Mouse1.48521226
82ZNF274_21170338_ChIP-Seq_K562_Hela1.47745512
83CBX2_27304074_Chip-Seq_ESCs_Mouse1.47068461
84SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.45204635
85GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45045998
86POU3F2_20337985_ChIP-ChIP_501MEL_Human1.43082788
87FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.42860223
88TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42546808
89FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.41363017
90SOX2_21211035_ChIP-Seq_LN229_Gbm1.40843066
91SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39998994
92HOXB4_20404135_ChIP-ChIP_EML_Mouse1.39547104
93MYC_18940864_ChIP-ChIP_HL60_Human1.39339380
94AR_25329375_ChIP-Seq_VCAP_Human1.38319918
95RNF2_27304074_Chip-Seq_NSC_Mouse1.38135633
96PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.37837561
97ERG_21242973_ChIP-ChIP_JURKAT_Human1.37194660
98SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.37035185
99DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.36389427
100SMAD3_21741376_ChIP-Seq_EPCs_Human1.36228932
101PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35537793
102NR3C1_23031785_ChIP-Seq_PC12_Mouse1.35332208
103OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34617050
104BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.34142260
105PIAS1_25552417_ChIP-Seq_VCAP_Human1.33172468
106YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32865152
107SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31917561
108VDR_22108803_ChIP-Seq_LS180_Human1.30024882
109CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.29862388
110ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.29795401
111FUS_26573619_Chip-Seq_HEK293_Human1.29373944
112IGF1R_20145208_ChIP-Seq_DFB_Human1.26600382
113TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.26332314
114MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.25927459
115RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24920334
116TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22411499
117STAT3_23295773_ChIP-Seq_U87_Human1.20483207
118RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.20235525
119P68_20966046_ChIP-Seq_HELA_Human1.19032698
120EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18734850
121FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.18399146
122SRY_22984422_ChIP-ChIP_TESTIS_Rat1.17299752
123SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.16935893
124TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15923044
125SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.15710044
126NANOG_18555785_ChIP-Seq_MESCs_Mouse1.15430608
127ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.15320456
128ER_23166858_ChIP-Seq_MCF-7_Human1.13317121
129RING1B_27294783_Chip-Seq_ESCs_Mouse1.13233326
130CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.12661790
131TFEB_21752829_ChIP-Seq_HELA_Human1.12363167
132TCF4_23295773_ChIP-Seq_U87_Human1.11700007
133CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.10739743
134AR_19668381_ChIP-Seq_PC3_Human1.10456968
135UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10121050
136JUN_21703547_ChIP-Seq_K562_Human1.09567987
137BCL6_27268052_Chip-Seq_Bcells_Human1.09013601
138MYC_19079543_ChIP-ChIP_MESCs_Mouse1.08941231
139DNAJC2_21179169_ChIP-ChIP_NT2_Human1.07399512
140P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07013860
141CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06919447
142YY1_22570637_ChIP-Seq_MALME-3M_Human1.06468479
143PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06436377
144RARB_24833708_ChIP-Seq_LIVER_Mouse1.05907725
145FOXP1_21924763_ChIP-Seq_HESCs_Human1.05647542
146CIITA_25753668_ChIP-Seq_RAJI_Human1.04317554
147AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04216130
148SMC4_20622854_ChIP-Seq_HELA_Human1.04037534
149RUNX2_22187159_ChIP-Seq_PCA_Human1.03873400
150ARNT_22903824_ChIP-Seq_MCF-7_Human1.02637175
151SMAD_19615063_ChIP-ChIP_OVARY_Human1.02457379
152* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01800978
153ELF1_20517297_ChIP-Seq_JURKAT_Human1.00498654
154SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.00347443
155PRDM14_20953172_ChIP-Seq_ESCs_Human0.99915542
156POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.98869567
157FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.98594452
158TBX5_21415370_ChIP-Seq_HL-1_Mouse0.98589518
159MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.98312731
160YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98009708
161CTCF_18555785_ChIP-Seq_MESCs_Mouse0.97962435
162RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.97532491
163SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.95233703
164* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.94241923
165HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.94056959
166MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.93859409
167ZNF263_19887448_ChIP-Seq_K562_Human0.93437922
168CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.92177126
169BCOR_27268052_Chip-Seq_Bcells_Human0.92075535
170TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91896323
171SMAD3_21741376_ChIP-Seq_ESCs_Human0.91474038
172AHR_22903824_ChIP-Seq_MCF-7_Human0.91376509
173SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.91217828
174ELK1_19687146_ChIP-ChIP_HELA_Human0.89894408
175CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.89379018
176NANOG_18555785_Chip-Seq_ESCs_Mouse0.89119479
177PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.87763200
178KLF4_18555785_ChIP-Seq_MESCs_Mouse0.87613375
179NR3C1_21868756_ChIP-Seq_MCF10A_Human0.86936471
180TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.86812765
181NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.86604110
182CBP_20019798_ChIP-Seq_JUKART_Human0.86255897
183IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.86255897
184CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.86189831
185EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.86184329
186* SOX9_26525672_Chip-Seq_HEART_Mouse0.85941832
187MAF_26560356_Chip-Seq_TH2_Human0.85553870
188CTCF_20526341_ChIP-Seq_ESCs_Human0.85374795
189POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.85359863
190RING1B_27294783_Chip-Seq_NPCs_Mouse0.83533639
191GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.82968439
192WT1_25993318_ChIP-Seq_PODOCYTE_Human0.82643274
193KDM2B_26808549_Chip-Seq_REH_Human0.82634237
194FLI1_21867929_ChIP-Seq_TH2_Mouse0.82536625

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.32487617
2MP0003880_abnormal_central_pattern5.01263898
3MP0002234_abnormal_pharynx_morphology4.84465431
4MP0000566_synostosis4.15994494
5MP0003635_abnormal_synaptic_transmissio3.89407314
6MP0003693_abnormal_embryo_hatching3.36364948
7MP0009745_abnormal_behavioral_response3.33852120
8MP0009046_muscle_twitch3.25591055
9MP0004270_analgesia3.24755764
10MP0002064_seizures3.21240915
11MP0002063_abnormal_learning/memory/cond3.20280900
12MP0001968_abnormal_touch/_nociception3.19467521
13MP0002572_abnormal_emotion/affect_behav2.83926459
14MP0002736_abnormal_nociception_after2.80166943
15MP0010307_abnormal_tumor_latency2.68468223
16MP0002734_abnormal_mechanical_nocicepti2.61718991
17MP0002272_abnormal_nervous_system2.60285791
18MP0003786_premature_aging2.52851219
19MP0002822_catalepsy2.50186287
20MP0005423_abnormal_somatic_nervous2.43162100
21MP0002735_abnormal_chemical_nociception2.41171906
22MP0008058_abnormal_DNA_repair2.38115844
23MP0003122_maternal_imprinting2.37400293
24MP0006276_abnormal_autonomic_nervous2.34239216
25MP0001486_abnormal_startle_reflex2.31926968
26MP0001501_abnormal_sleep_pattern2.30992939
27MP0001440_abnormal_grooming_behavior2.20786343
28MP0003787_abnormal_imprinting2.06947125
29MP0002733_abnormal_thermal_nociception2.06089119
30MP0002067_abnormal_sensory_capabilities2.05932004
31MP0009780_abnormal_chondrocyte_physiolo2.05232671
32MP0005646_abnormal_pituitary_gland2.03136403
33MP0001970_abnormal_pain_threshold1.96210129
34MP0010368_abnormal_lymphatic_system1.91779737
35MP0003718_maternal_effect1.86235092
36MP0001529_abnormal_vocalization1.86223075
37MP0003111_abnormal_nucleus_morphology1.83073496
38MP0001984_abnormal_olfaction1.81284633
39MP0002184_abnormal_innervation1.79489290
40MP0004924_abnormal_behavior1.76461352
41MP0005386_behavior/neurological_phenoty1.76461352
42MP0002557_abnormal_social/conspecific_i1.75242892
43MP0006082_CNS_inflammation1.73701095
44MP0000778_abnormal_nervous_system1.69692629
45MP0003045_fibrosis1.69245549
46MP0008932_abnormal_embryonic_tissue1.64507401
47MP0002163_abnormal_gland_morphology1.64228938
48MP0003329_amyloid_beta_deposits1.63046149
49MP0008007_abnormal_cellular_replicative1.62319789
50MP0008789_abnormal_olfactory_epithelium1.60975720
51MP0004142_abnormal_muscle_tone1.60855280
52MP0005645_abnormal_hypothalamus_physiol1.60636458
53MP0003879_abnormal_hair_cell1.60459521
54MP0004811_abnormal_neuron_physiology1.59921206
55MP0002909_abnormal_adrenal_gland1.55667072
56MP0008569_lethality_at_weaning1.54349114
57MP0002837_dystrophic_cardiac_calcinosis1.50631719
58MP0001905_abnormal_dopamine_level1.50618356
59MP0005623_abnormal_meninges_morphology1.46471407
60MP0001346_abnormal_lacrimal_gland1.45624268
61MP0006036_abnormal_mitochondrial_physio1.45322469
62MP0005671_abnormal_response_to1.44436156
63MP0000955_abnormal_spinal_cord1.43012331
64MP0010094_abnormal_chromosome_stability1.42471872
65MP0003077_abnormal_cell_cycle1.39947503
66MP0009053_abnormal_anal_canal1.39534855
67MP0002066_abnormal_motor_capabilities/c1.39210718
68MP0001919_abnormal_reproductive_system1.35983552
69MP0004858_abnormal_nervous_system1.35943265
70MP0004957_abnormal_blastocyst_morpholog1.35056792
71MP0002233_abnormal_nose_morphology1.34841392
72MP0002882_abnormal_neuron_morphology1.33571916
73MP0001502_abnormal_circadian_rhythm1.32025509
74MP0000733_abnormal_muscle_development1.30522049
75MP0001661_extended_life_span1.30173070
76MP0002876_abnormal_thyroid_physiology1.29141571
77MP0003763_abnormal_thymus_physiology1.26760839
78MP0009333_abnormal_splenocyte_physiolog1.25172119
79MP0000013_abnormal_adipose_tissue1.24766995
80MP0000751_myopathy1.21361312
81MP0001188_hyperpigmentation1.21311334
82MP0010386_abnormal_urinary_bladder1.20050887
83MP0000537_abnormal_urethra_morphology1.19784617
84MP0004084_abnormal_cardiac_muscle1.17426489
85MP0001764_abnormal_homeostasis1.13679216
86MP0000467_abnormal_esophagus_morphology1.11921093
87MP0003633_abnormal_nervous_system1.10979165
88MP0005389_reproductive_system_phenotype1.10847556
89MP0010030_abnormal_orbit_morphology1.04891636
90MP0008260_abnormal_autophagy1.04275322
91MP0005167_abnormal_blood-brain_barrier1.04204768
92MP0000358_abnormal_cell_content/1.04150823
93MP0008872_abnormal_physiological_respon1.03439439
94MP0002152_abnormal_brain_morphology1.02166511
95MP0003121_genomic_imprinting0.99961376
96MP0005551_abnormal_eye_electrophysiolog0.99557228
97MP0004885_abnormal_endolymph0.98974046
98MP0003631_nervous_system_phenotype0.98598647
99MP0005367_renal/urinary_system_phenotyp0.97269959
100MP0000516_abnormal_urinary_system0.97269959
101MP0002069_abnormal_eating/drinking_beha0.97180644
102MP0008995_early_reproductive_senescence0.94420931
103MP0002229_neurodegeneration0.92666783
104MP0005394_taste/olfaction_phenotype0.91226246
105MP0005499_abnormal_olfactory_system0.91226246
106MP0002210_abnormal_sex_determination0.90650593
107MP0001727_abnormal_embryo_implantation0.90073542
108MP0002160_abnormal_reproductive_system0.88134718
109MP0003937_abnormal_limbs/digits/tail_de0.87307600
110MP0001963_abnormal_hearing_physiology0.86457320
111MP0004085_abnormal_heartbeat0.85566222
112MP0005535_abnormal_body_temperature0.85493406
113MP0000631_abnormal_neuroendocrine_gland0.85151496
114MP0000749_muscle_degeneration0.85031350
115MP0008877_abnormal_DNA_methylation0.84729343
116MP0003123_paternal_imprinting0.77682566
117MP0005379_endocrine/exocrine_gland_phen0.77643306
118MP0000750_abnormal_muscle_regeneration0.76813453
119MP0004233_abnormal_muscle_weight0.76671301
120MP0004215_abnormal_myocardial_fiber0.76520896
121MP0003183_abnormal_peptide_metabolism0.75917720
122MP0004145_abnormal_muscle_electrophysio0.75711255
123MP0001177_atelectasis0.75621460
124MP0004742_abnormal_vestibular_system0.75613353
125MP0008874_decreased_physiological_sensi0.75191543
126MP0002752_abnormal_somatic_nervous0.75151691
127MP0001664_abnormal_digestion0.74567288
128MP0004043_abnormal_pH_regulation0.71795575
129MP0001929_abnormal_gametogenesis0.70719289
130MP0005330_cardiomyopathy0.70625653
131MP0005332_abnormal_amino_acid0.70064984
132MP0003119_abnormal_digestive_system0.69171287
133MP0003634_abnormal_glial_cell0.68853045
134MP0003632_abnormal_nervous_system0.68584022
135MP0002102_abnormal_ear_morphology0.68273900
136MP0000604_amyloidosis0.67337239
137MP0006035_abnormal_mitochondrial_morpho0.66928231
138MP0001119_abnormal_female_reproductive0.66588507
139MP0000653_abnormal_sex_gland0.65661351
140MP0002638_abnormal_pupillary_reflex0.65412498
141MP0002653_abnormal_ependyma_morphology0.64456708
142MP0002249_abnormal_larynx_morphology0.64053233
143MP0003646_muscle_fatigue0.63661069
144MP0001986_abnormal_taste_sensitivity0.62712333
145MP0002090_abnormal_vision0.62194547
146MP0003283_abnormal_digestive_organ0.62133791
147MP0001145_abnormal_male_reproductive0.61909952
148MP0004133_heterotaxia0.61451053
149MP0000372_irregular_coat_pigmentation0.60864785
150MP0004484_altered_response_of0.60853323
151MP0001943_abnormal_respiration0.59343392
152MP0000026_abnormal_inner_ear0.54050039
153MP0010770_preweaning_lethality0.52768286
154MP0002082_postnatal_lethality0.52768286
155MP0003137_abnormal_impulse_conducting0.52441156
156MP0002751_abnormal_autonomic_nervous0.51555415
157MP0010769_abnormal_survival0.50774305
158MP0003956_abnormal_body_size0.50551723
159MP0002332_abnormal_exercise_endurance0.47874118
160MP0004036_abnormal_muscle_relaxation0.47851435

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.65148591
2Myokymia (HP:0002411)5.72408591
3Atonic seizures (HP:0010819)5.59212643
4Epileptic encephalopathy (HP:0200134)5.26963406
5Focal seizures (HP:0007359)5.25625434
6Febrile seizures (HP:0002373)4.73484878
7Ureteral stenosis (HP:0000071)4.56801823
8Visual hallucinations (HP:0002367)4.54106402
9Absence seizures (HP:0002121)4.40088985
10Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.37180584
11Decreased activity of mitochondrial respiratory chain (HP:0008972)4.37180584
12Hyperventilation (HP:0002883)4.30511889
13Sparse lateral eyebrow (HP:0005338)4.29745572
14Intestinal fistula (HP:0100819)4.13447512
15Autoimmune thrombocytopenia (HP:0001973)4.11306598
16Ureteral obstruction (HP:0006000)4.08596996
17Dialeptic seizures (HP:0011146)3.97617494
18Progressive cerebellar ataxia (HP:0002073)3.93839209
19Generalized tonic-clonic seizures (HP:0002069)3.78636936
20Short 5th finger (HP:0009237)3.72545429
21Lip pit (HP:0100267)3.60967295
22Anal stenosis (HP:0002025)3.56955256
23Aplasia/Hypoplasia of the 5th finger (HP:0006262)3.53550780
24Pheochromocytoma (HP:0002666)3.44531208
25Abnormal eating behavior (HP:0100738)3.29923800
26Polyphagia (HP:0002591)3.23931405
27Broad-based gait (HP:0002136)3.18046290
28Neuroendocrine neoplasm (HP:0100634)3.11424985
29Hepatic necrosis (HP:0002605)3.11158945
30Aplastic anemia (HP:0001915)3.09287935
31Impaired vibration sensation in the lower limbs (HP:0002166)3.08640768
32Hepatocellular necrosis (HP:0001404)3.07675329
33Abnormal hair whorl (HP:0010721)3.05135956
34Failure to thrive in infancy (HP:0001531)3.02177878
35Poor eye contact (HP:0000817)2.93555522
36Limb dystonia (HP:0002451)2.90285428
37T lymphocytopenia (HP:0005403)2.88334505
38Amblyopia (HP:0000646)2.86313324
39Epileptiform EEG discharges (HP:0011182)2.84895998
40Gait imbalance (HP:0002141)2.81576309
41Increased intramyocellular lipid droplets (HP:0012240)2.80285155
42Carpal bone hypoplasia (HP:0001498)2.79166920
43Ankle clonus (HP:0011448)2.78527005
44Anxiety (HP:0000739)2.78452300
45Dysdiadochokinesis (HP:0002075)2.77626841
46Cutaneous melanoma (HP:0012056)2.76447436
47Acute necrotizing encephalopathy (HP:0006965)2.76265455
48Abnormal mitochondria in muscle tissue (HP:0008316)2.75788845
49Poor suck (HP:0002033)2.74387093
50Depression (HP:0000716)2.73608045
51Gaze-evoked nystagmus (HP:0000640)2.71559454
52Impaired social interactions (HP:0000735)2.71517476
53Abnormal social behavior (HP:0012433)2.71517476
54Depressed nasal tip (HP:0000437)2.68223510
55Aplasia/Hypoplasia involving the musculature (HP:0001460)2.66739323
56EEG with generalized epileptiform discharges (HP:0011198)2.66639573
57Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.64789030
58Truncal ataxia (HP:0002078)2.61182279
59Progressive inability to walk (HP:0002505)2.60734610
60Action tremor (HP:0002345)2.60209399
61Excessive salivation (HP:0003781)2.59206574
62Drooling (HP:0002307)2.59206574
63Cerebral hypomyelination (HP:0006808)2.58692656
64Increased CSF lactate (HP:0002490)2.57856811
65Abnormality of T cell number (HP:0011839)2.56246485
66Supranuclear gaze palsy (HP:0000605)2.56202378
67Abnormality of the distal phalanges of the toes (HP:0010182)2.55082375
68Increased serum lactate (HP:0002151)2.51998686
69Hypsarrhythmia (HP:0002521)2.51779513
70Unsteady gait (HP:0002317)2.51762646
71Abnormality of the lower motor neuron (HP:0002366)2.49137456
72Progressive macrocephaly (HP:0004481)2.48177536
73Preauricular pit (HP:0004467)2.46108495
74Periauricular skin pits (HP:0100277)2.46108495
75Congenital primary aphakia (HP:0007707)2.45925983
76Urinary bladder sphincter dysfunction (HP:0002839)2.43796126
77Oligomenorrhea (HP:0000876)2.43060778
78Lactic acidosis (HP:0003128)2.42742296
79Posterior subcapsular cataract (HP:0007787)2.39843711
80Increased muscle lipid content (HP:0009058)2.39184038
81Medial flaring of the eyebrow (HP:0010747)2.38075526
82Ectopic kidney (HP:0000086)2.37774624
83Microvesicular hepatic steatosis (HP:0001414)2.37674587
84Popliteal pterygium (HP:0009756)2.37625366
85Dysmetria (HP:0001310)2.37477345
86Abnormality of the labia minora (HP:0012880)2.36831646
87Type I transferrin isoform profile (HP:0003642)2.36147136
88Self-mutilation (HP:0000742)2.34948452
893-Methylglutaconic aciduria (HP:0003535)2.34241522
90Microretrognathia (HP:0000308)2.33727632
91Nephrogenic diabetes insipidus (HP:0009806)2.32537126
92Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.32337184
93Abnormal protein N-linked glycosylation (HP:0012347)2.32337184
94Abnormal protein glycosylation (HP:0012346)2.32337184
95Abnormal glycosylation (HP:0012345)2.32337184
96Facial cleft (HP:0002006)2.32238590
97Inability to walk (HP:0002540)2.31774942
98Abnormality of the astrocytes (HP:0100707)2.30923466
99Astrocytoma (HP:0009592)2.30923466
100Scanning speech (HP:0002168)2.29981120
101Fetal akinesia sequence (HP:0001989)2.28290383
102Abnormality of binocular vision (HP:0011514)2.26885946
103Diplopia (HP:0000651)2.26885946
104Hypokinesia (HP:0002375)2.26590335
105Specific learning disability (HP:0001328)2.25902408
106Torticollis (HP:0000473)2.25285102
107Hypoventilation (HP:0002791)2.23946869
108Generalized aminoaciduria (HP:0002909)2.23946437
109Spastic gait (HP:0002064)2.23684379
110Mutism (HP:0002300)2.23513944
111Status epilepticus (HP:0002133)2.22827468
112Bradykinesia (HP:0002067)2.22521281
113Postural instability (HP:0002172)2.22459470
114Focal dystonia (HP:0004373)2.22137422
115Ragged-red muscle fibers (HP:0003200)2.21756627
116Urinary urgency (HP:0000012)2.21748416
117Entropion (HP:0000621)2.21309648
118Septate vagina (HP:0001153)2.19750657
119Cerebral edema (HP:0002181)2.19622175
120CNS demyelination (HP:0007305)2.17733313
121Termporal pattern (HP:0011008)2.17400533
122Insidious onset (HP:0003587)2.17400533
123Methylmalonic aciduria (HP:0012120)2.15473194
124Acute encephalopathy (HP:0006846)2.14709064
125Exercise intolerance (HP:0003546)2.14287916
126Abnormal number of incisors (HP:0011064)2.11509713
127Long palpebral fissure (HP:0000637)2.11414834
128Tetraplegia (HP:0002445)2.10817294
129Genetic anticipation (HP:0003743)2.09091632
130Renal cortical cysts (HP:0000803)2.08802793
131Absent speech (HP:0001344)2.08420763
132Protruding tongue (HP:0010808)2.07505553
133Mitochondrial inheritance (HP:0001427)2.05938442
134Impaired vibratory sensation (HP:0002495)2.05874265
135Abnormality of the corticospinal tract (HP:0002492)2.05539471
136Impaired pain sensation (HP:0007328)2.04940960
137Abnormality of pain sensation (HP:0010832)2.04940960
138Blue irides (HP:0000635)2.04700795
139Narrow nasal bridge (HP:0000446)2.04234128
140Esotropia (HP:0000565)2.02840196
141Craniofacial dystonia (HP:0012179)2.02035407
142Hyperthyroidism (HP:0000836)2.01612751
143Hemiparesis (HP:0001269)2.01437548
144Generalized myoclonic seizures (HP:0002123)2.01219763
145Delusions (HP:0000746)2.00259662
146Agitation (HP:0000713)1.99855179
147Resting tremor (HP:0002322)1.99664084
148Ectropion (HP:0000656)1.97796482
149Impaired smooth pursuit (HP:0007772)1.97679212
150Abnormality of dicarboxylic acid metabolism (HP:0010995)1.96613856
151Dicarboxylic aciduria (HP:0003215)1.96613856
152Sleep apnea (HP:0010535)1.94980570
153Cholecystitis (HP:0001082)1.94215231
154Abnormal gallbladder physiology (HP:0012438)1.94215231
155Dysmetric saccades (HP:0000641)1.94141972
156Trismus (HP:0000211)1.93004369
157Neoplasm of the peripheral nervous system (HP:0100007)1.92488889
158Squamous cell carcinoma (HP:0002860)1.91875390
159Genital tract atresia (HP:0001827)1.91116103
160Lower limb muscle weakness (HP:0007340)1.90846779
161Vaginal atresia (HP:0000148)1.89946115
162Anal atresia (HP:0002023)1.89634909
163Generalized hypotonia (HP:0001290)1.88097216
164Glioma (HP:0009733)1.87421346
165Increased serum pyruvate (HP:0003542)1.86698542
166Abnormality of glycolysis (HP:0004366)1.86698542
167Redundant skin (HP:0001582)1.86530432
168Acute hepatic failure (HP:0006554)1.85919696
169Cholelithiasis (HP:0001081)1.85840773
170Rhabdomyolysis (HP:0003201)1.85102292
171Coarctation of aorta (HP:0001680)1.84647362
172Rough bone trabeculation (HP:0100670)1.83918680
173Emotional lability (HP:0000712)1.83686558
174CNS hypomyelination (HP:0003429)1.82326760
175Methylmalonic acidemia (HP:0002912)1.80261830
176Abnormality of the fingertips (HP:0001211)1.79083274
177Ependymoma (HP:0002888)1.78491090
178J-shaped sella turcica (HP:0002680)1.75992518
179Absent thumb (HP:0009777)1.75432794
180Abnormal gallbladder morphology (HP:0012437)1.74875414
181Abnormality of cochlea (HP:0000375)1.74243429
182Fibular aplasia (HP:0002990)1.73401494
183Hypoproteinemia (HP:0003075)1.72766759
184Retinal dysplasia (HP:0007973)1.72284995
185Reduced subcutaneous adipose tissue (HP:0003758)1.69473437
186Lethargy (HP:0001254)1.68751162

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.32877028
2NTRK33.99167721
3BUB13.91265049
4STK243.91018617
5BCKDK3.89176943
6WNK43.52699798
7MAP3K123.44267289
8MAP3K43.40720037
9EPHA43.30031984
10MAP2K73.12556104
11TESK23.03128703
12MAP3K93.01778317
13TXK2.94911239
14STK392.92418807
15MARK12.81899195
16ZAK2.60707483
17MINK12.56585018
18KDR2.56195666
19MAPKAPK32.49139062
20EEF2K2.43211227
21DAPK22.37212867
22SRPK12.34440437
23CDK192.27456596
24MAP2K42.14304892
25PLK22.13844144
26DAPK11.93002781
27NTRK21.83072406
28VRK21.75350824
29ILK1.73100865
30TESK11.68233713
31MAP3K31.65235200
32PAK61.61439918
33GRK51.57986853
34ARAF1.56864542
35PRPF4B1.55346785
36TTK1.48734312
37AKT31.47536142
38CCNB11.46107296
39MAP3K111.44631075
40CHEK21.44562624
41MAPK131.42784661
42CDC71.41257585
43KSR11.40980864
44OXSR11.35026737
45PRKCG1.34596620
46PIM21.34095618
47CDK51.33522266
48TSSK61.28136726
49TRIM281.27717914
50KSR21.27616055
51MAP4K21.25247204
52SIK31.21005475
53PRKCQ1.19810988
54NTRK11.19643168
55EIF2AK31.17906010
56PRKD31.16797687
57PNCK1.14996236
58SGK2231.11069472
59SGK4941.11069472
60CAMK2A1.09789216
61CAMKK11.09771278
62NME11.08489130
63CSNK1A1L1.06628625
64UHMK11.06249263
65BRSK11.05175548
66PDK40.98555231
67PDK30.98555231
68SGK20.97616879
69TNIK0.97156841
70RIPK40.96519031
71CDK180.96204665
72CAMK2B0.91684289
73CDK140.91514509
74PHKG10.90757023
75PHKG20.90757023
76CSNK1G10.90750724
77JAK30.89633255
78CAMKK20.89232044
79CDK150.88713084
80AURKA0.88174205
81WNK30.86585734
82BCR0.85904571
83STK380.85650532
84NEK10.84739900
85NME20.84460492
86BRAF0.83725612
87NUAK10.79646291
88LATS20.79234319
89ATR0.77988757
90FES0.77313783
91PTK2B0.77047325
92PLK10.76072646
93SIK20.75988146
94CDK11A0.75969383
95MAPKAPK50.74723806
96PRKCE0.73956091
97BMPR20.73863287
98VRK10.72707825
99PAK30.72603365
100FER0.70475487
101DYRK1A0.67445889
102CSNK1G20.65110762
103IRAK30.64015450
104MAP3K20.63619116
105SGK30.61366730
106DAPK30.61315046
107CAMK2G0.60691032
108EPHA20.60257521
109CAMK10.59989219
110PRKCH0.59260466
111PINK10.57727192
112PDK20.56199228
113ADRBK10.55714199
114CAMK2D0.55651818
115GRK70.54567325
116TNK20.54196993
117MYLK0.53625454
118SGK10.52932870
119LMTK20.52326751
120PBK0.52067101
121ADRBK20.51072455
122STK110.50859727
123RPS6KA50.50013104
124LIMK10.49454654
125MAP3K130.48579538
126MAP2K10.48076036
127PRKCI0.47576838
128TYRO30.47455136
129ERBB30.45708241
130EIF2AK10.44474842
131STK40.43613900
132PRKCZ0.43295191
133MAP3K50.42455660
134RET0.42123145
135WEE10.41564070
136MAPK110.41174549
137RAF10.40771031
138PAK10.40575859
139ROCK20.39496453
140EIF2AK20.38998358
141AURKB0.38709970
142RPS6KA30.37864838
143RPS6KL10.36331217
144RPS6KC10.36331217
145MUSK0.35139601
146TLK10.35079193
147PRKACA0.34699289
148RPS6KA60.33249884
149RPS6KA20.33229215
150AKT20.32393339
151PLK30.31907636
152CSNK1G30.31415037
153MAP3K10.30786712
154SCYL20.30748591
155CAMK40.30738298
156CSNK2A10.26971185

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.20358923
2Synaptic vesicle cycle_Homo sapiens_hsa047214.26213804
3Nicotine addiction_Homo sapiens_hsa050334.12502416
4Collecting duct acid secretion_Homo sapiens_hsa049663.10227250
5GABAergic synapse_Homo sapiens_hsa047272.81649351
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.74654447
7Fatty acid elongation_Homo sapiens_hsa000622.54964938
8Olfactory transduction_Homo sapiens_hsa047402.54468507
9Morphine addiction_Homo sapiens_hsa050322.48372274
10Circadian entrainment_Homo sapiens_hsa047132.45755665
11RNA polymerase_Homo sapiens_hsa030202.39443256
12DNA replication_Homo sapiens_hsa030302.36610012
13Amphetamine addiction_Homo sapiens_hsa050312.31094375
14Long-term potentiation_Homo sapiens_hsa047202.26569975
15Glutamatergic synapse_Homo sapiens_hsa047242.21434297
16Pyrimidine metabolism_Homo sapiens_hsa002402.14254443
17Dopaminergic synapse_Homo sapiens_hsa047282.08970101
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.06163665
19Vitamin B6 metabolism_Homo sapiens_hsa007502.04923360
20Vibrio cholerae infection_Homo sapiens_hsa051102.04198422
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.01162387
22Oxidative phosphorylation_Homo sapiens_hsa001901.96400732
23Insulin secretion_Homo sapiens_hsa049111.94496857
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.92219053
25Taste transduction_Homo sapiens_hsa047421.90656209
26Base excision repair_Homo sapiens_hsa034101.87688416
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.85456280
28Biosynthesis of amino acids_Homo sapiens_hsa012301.84318516
29Salivary secretion_Homo sapiens_hsa049701.79784478
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.74033727
31Serotonergic synapse_Homo sapiens_hsa047261.70488269
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.70165122
33Sulfur relay system_Homo sapiens_hsa041221.69891529
34Non-homologous end-joining_Homo sapiens_hsa034501.68993355
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.66065037
36N-Glycan biosynthesis_Homo sapiens_hsa005101.62670958
37Primary immunodeficiency_Homo sapiens_hsa053401.62484987
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.60417806
39Mismatch repair_Homo sapiens_hsa034301.60231001
40Cholinergic synapse_Homo sapiens_hsa047251.59713312
41Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.59030963
42Cocaine addiction_Homo sapiens_hsa050301.58997457
43Homologous recombination_Homo sapiens_hsa034401.56264968
44Long-term depression_Homo sapiens_hsa047301.52748207
45Gastric acid secretion_Homo sapiens_hsa049711.49645936
46Renin secretion_Homo sapiens_hsa049241.47695600
47RNA transport_Homo sapiens_hsa030131.47561740
48Nucleotide excision repair_Homo sapiens_hsa034201.47394158
49Parkinsons disease_Homo sapiens_hsa050121.43669206
50Aldosterone synthesis and secretion_Homo sapiens_hsa049251.43066064
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.42200739
52Fanconi anemia pathway_Homo sapiens_hsa034601.41552570
53Calcium signaling pathway_Homo sapiens_hsa040201.38619606
54Protein export_Homo sapiens_hsa030601.37825493
55Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.35911424
56Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.35224521
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.34465807
58One carbon pool by folate_Homo sapiens_hsa006701.34001044
59Oxytocin signaling pathway_Homo sapiens_hsa049211.31488611
60Alzheimers disease_Homo sapiens_hsa050101.27341345
61Cardiac muscle contraction_Homo sapiens_hsa042601.26764265
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.26746128
63Folate biosynthesis_Homo sapiens_hsa007901.18378397
64Gap junction_Homo sapiens_hsa045401.16988426
65Arginine and proline metabolism_Homo sapiens_hsa003301.10818345
66Drug metabolism - other enzymes_Homo sapiens_hsa009831.10477959
67Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.08470744
68Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.08063748
69Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.07956865
70Purine metabolism_Homo sapiens_hsa002301.04925997
71Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.04566470
72Selenocompound metabolism_Homo sapiens_hsa004501.03990792
73GnRH signaling pathway_Homo sapiens_hsa049121.03907230
74Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00987608
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.97058901
76cAMP signaling pathway_Homo sapiens_hsa040240.94556525
77Spliceosome_Homo sapiens_hsa030400.93873101
78Huntingtons disease_Homo sapiens_hsa050160.93800456
79mRNA surveillance pathway_Homo sapiens_hsa030150.92539645
80Lysine degradation_Homo sapiens_hsa003100.89808252
81Axon guidance_Homo sapiens_hsa043600.89561308
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.88134803
832-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.88011704
84Cell cycle_Homo sapiens_hsa041100.87592661
85Propanoate metabolism_Homo sapiens_hsa006400.86965427
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82879828
87Estrogen signaling pathway_Homo sapiens_hsa049150.82798495
88Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.82771120
89Phototransduction_Homo sapiens_hsa047440.81691816
90p53 signaling pathway_Homo sapiens_hsa041150.81449142
91Basal transcription factors_Homo sapiens_hsa030220.80742442
92Type II diabetes mellitus_Homo sapiens_hsa049300.80525375
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79678521
94Peroxisome_Homo sapiens_hsa041460.77094998
95Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.75905451
96Rheumatoid arthritis_Homo sapiens_hsa053230.74911342
97Melanogenesis_Homo sapiens_hsa049160.74884177
98cGMP-PKG signaling pathway_Homo sapiens_hsa040220.74180738
99ErbB signaling pathway_Homo sapiens_hsa040120.74083048
100Pyruvate metabolism_Homo sapiens_hsa006200.73785243
101Vascular smooth muscle contraction_Homo sapiens_hsa042700.71515865
102Metabolic pathways_Homo sapiens_hsa011000.71337885
103Butanoate metabolism_Homo sapiens_hsa006500.69170905
104Glioma_Homo sapiens_hsa052140.66947805
105Type I diabetes mellitus_Homo sapiens_hsa049400.65463137
106Oocyte meiosis_Homo sapiens_hsa041140.64668148
107Fatty acid metabolism_Homo sapiens_hsa012120.61066717
108Phagosome_Homo sapiens_hsa041450.60509652
109SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60149641
110Steroid biosynthesis_Homo sapiens_hsa001000.59029496
111Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58648406
112Antigen processing and presentation_Homo sapiens_hsa046120.57911469
113Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57209052
114AMPK signaling pathway_Homo sapiens_hsa041520.57197395
115Glucagon signaling pathway_Homo sapiens_hsa049220.56123963
116Dilated cardiomyopathy_Homo sapiens_hsa054140.54954154
117Thyroid hormone synthesis_Homo sapiens_hsa049180.54439382
118Systemic lupus erythematosus_Homo sapiens_hsa053220.53846059
119Salmonella infection_Homo sapiens_hsa051320.53547835
120Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52443133
121RNA degradation_Homo sapiens_hsa030180.50640772
122Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49855104
123Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49399563
124Pancreatic secretion_Homo sapiens_hsa049720.49096818
125MAPK signaling pathway_Homo sapiens_hsa040100.47378781
126Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47033627
127Alcoholism_Homo sapiens_hsa050340.45377428
128Ribosome_Homo sapiens_hsa030100.45019571
129Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42708289
130Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.42063985
131Pentose phosphate pathway_Homo sapiens_hsa000300.41009656
132beta-Alanine metabolism_Homo sapiens_hsa004100.40616737
133Circadian rhythm_Homo sapiens_hsa047100.40142902
134Ras signaling pathway_Homo sapiens_hsa040140.38187245
135Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38080871
136Shigellosis_Homo sapiens_hsa051310.37964434
137Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.37277943
138Arginine biosynthesis_Homo sapiens_hsa002200.35286919
139Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34380826
140Bile secretion_Homo sapiens_hsa049760.34096853
141Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33446076
142Prion diseases_Homo sapiens_hsa050200.33294852
143Phospholipase D signaling pathway_Homo sapiens_hsa040720.32587594
144Inositol phosphate metabolism_Homo sapiens_hsa005620.31853183
145Regulation of autophagy_Homo sapiens_hsa041400.31390384
146Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.31359170
147Tyrosine metabolism_Homo sapiens_hsa003500.31265819
148Sulfur metabolism_Homo sapiens_hsa009200.29460691
149Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29055955
150Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.28802996
151Insulin signaling pathway_Homo sapiens_hsa049100.27036803
152Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.25893978
153Epstein-Barr virus infection_Homo sapiens_hsa051690.25572172
154Rap1 signaling pathway_Homo sapiens_hsa040150.25137986
155Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.25024731
156Phenylalanine metabolism_Homo sapiens_hsa003600.24917654
157Dorso-ventral axis formation_Homo sapiens_hsa043200.24872039
158Neurotrophin signaling pathway_Homo sapiens_hsa047220.24713669
159Choline metabolism in cancer_Homo sapiens_hsa052310.24580213
160Ovarian steroidogenesis_Homo sapiens_hsa049130.22077999
161Carbon metabolism_Homo sapiens_hsa012000.21974004
162Endocytosis_Homo sapiens_hsa041440.21881005
163Fructose and mannose metabolism_Homo sapiens_hsa000510.21277976
164Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.19598192
165Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.19054719

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