SNAP91

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.20811772
2synaptic vesicle maturation (GO:0016188)5.74294995
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.56714216
4vocalization behavior (GO:0071625)5.55869345
5synaptic vesicle exocytosis (GO:0016079)5.51839775
6locomotory exploration behavior (GO:0035641)5.43684897
7glutamate secretion (GO:0014047)5.38602461
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.37202919
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.16263895
10neuron cell-cell adhesion (GO:0007158)5.06270716
11regulation of synaptic vesicle exocytosis (GO:2000300)4.99925778
12protein localization to synapse (GO:0035418)4.87199496
13regulation of glutamate receptor signaling pathway (GO:1900449)4.73846585
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.65690079
15synaptic vesicle docking involved in exocytosis (GO:0016081)4.57204658
16exploration behavior (GO:0035640)4.53678437
17neurotransmitter secretion (GO:0007269)4.49970034
18layer formation in cerebral cortex (GO:0021819)4.49288580
19regulation of synaptic vesicle transport (GO:1902803)4.40782796
20L-amino acid import (GO:0043092)4.32681260
21neuronal action potential propagation (GO:0019227)4.25292000
22glutamate receptor signaling pathway (GO:0007215)4.24988547
23regulation of long-term neuronal synaptic plasticity (GO:0048169)4.23149518
24regulation of neuronal synaptic plasticity (GO:0048168)4.17002832
25synaptic transmission, glutamatergic (GO:0035249)4.14985544
26regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.11381237
27regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.08899953
28gamma-aminobutyric acid transport (GO:0015812)4.06709193
29proline transport (GO:0015824)4.02138950
30potassium ion homeostasis (GO:0055075)4.01698944
31neuron-neuron synaptic transmission (GO:0007270)4.00529022
32dendritic spine morphogenesis (GO:0060997)3.99158745
33neuron recognition (GO:0008038)3.95680168
34regulation of synapse structural plasticity (GO:0051823)3.91988671
35neuronal ion channel clustering (GO:0045161)3.91889367
36neurotransmitter-gated ion channel clustering (GO:0072578)3.89389837
37potassium ion import (GO:0010107)3.81593348
38amino acid import (GO:0043090)3.81444961
39neurotransmitter transport (GO:0006836)3.73391042
40regulation of voltage-gated calcium channel activity (GO:1901385)3.73038740
41regulation of synapse maturation (GO:0090128)3.72430457
42regulation of excitatory postsynaptic membrane potential (GO:0060079)3.71639645
43long-term memory (GO:0007616)3.70625153
44cellular sodium ion homeostasis (GO:0006883)3.69479329
45cellular potassium ion homeostasis (GO:0030007)3.68978731
46regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.68346012
47positive regulation of synapse maturation (GO:0090129)3.66646412
48axon ensheathment in central nervous system (GO:0032291)3.66441072
49central nervous system myelination (GO:0022010)3.66441072
50positive regulation of membrane potential (GO:0045838)3.61651430
51synaptic vesicle endocytosis (GO:0048488)3.61150136
52regulation of postsynaptic membrane potential (GO:0060078)3.59255027
53postsynaptic membrane organization (GO:0001941)3.58958590
54gamma-aminobutyric acid signaling pathway (GO:0007214)3.57873584
55positive regulation of dendritic spine morphogenesis (GO:0061003)3.57790055
56positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.56396573
57negative regulation of dendrite morphogenesis (GO:0050774)3.52681744
58axonal fasciculation (GO:0007413)3.51081371
59regulation of neurotransmitter secretion (GO:0046928)3.47399143
60membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.45793571
61transmission of nerve impulse (GO:0019226)3.45654577
62negative regulation of synaptic transmission, GABAergic (GO:0032229)3.45116153
63positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.42823022
64regulation of neurotransmitter levels (GO:0001505)3.41417609
65activation of protein kinase A activity (GO:0034199)3.40822442
66dendrite morphogenesis (GO:0048813)3.38414718
67cerebellar Purkinje cell differentiation (GO:0021702)3.37487690
68regulation of synaptic plasticity (GO:0048167)3.35687880
69presynaptic membrane assembly (GO:0097105)3.35140342
70regulation of dendritic spine morphogenesis (GO:0061001)3.32459040
71sodium ion export (GO:0071436)3.31582972
72regulation of vesicle fusion (GO:0031338)3.30667919
73regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.30375412
74regulation of synaptic transmission, glutamatergic (GO:0051966)3.27110739
75long-term synaptic potentiation (GO:0060291)3.26627890
76G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.24981606
77synapse assembly (GO:0007416)3.24251185
78neurotransmitter uptake (GO:0001504)3.22430003
79cerebellar granule cell differentiation (GO:0021707)3.22331319
80innervation (GO:0060384)3.22107437
81cell migration in hindbrain (GO:0021535)3.19785778
82regulation of ARF protein signal transduction (GO:0032012)3.18721478
83synaptic vesicle transport (GO:0048489)3.18478913
84establishment of synaptic vesicle localization (GO:0097480)3.18478913
85regulation of neurotransmitter transport (GO:0051588)3.17694837
86cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.17436665
87presynaptic membrane organization (GO:0097090)3.17158923
88detection of calcium ion (GO:0005513)3.16916963
89auditory behavior (GO:0031223)3.16727335
90neuromuscular synaptic transmission (GO:0007274)3.16310039
91positive regulation of synaptic transmission, GABAergic (GO:0032230)3.15793336
92neuromuscular process controlling balance (GO:0050885)3.15418460
93response to histamine (GO:0034776)3.15265563
94positive regulation of neurotransmitter secretion (GO:0001956)3.12543136
95membrane depolarization (GO:0051899)3.09938042
96cell differentiation in hindbrain (GO:0021533)3.09821941
97establishment of mitochondrion localization (GO:0051654)3.08920395
98cell communication involved in cardiac conduction (GO:0086065)3.08132910
99positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.06553731
100behavioral fear response (GO:0001662)3.06552957
101behavioral defense response (GO:0002209)3.06552957
102acidic amino acid transport (GO:0015800)3.06424654
103membrane hyperpolarization (GO:0060081)3.05596158
104cell communication by electrical coupling (GO:0010644)3.05291749
105G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.05119031
106response to auditory stimulus (GO:0010996)3.04814627
107membrane depolarization during action potential (GO:0086010)3.04262754
108positive regulation of neurotransmitter transport (GO:0051590)3.02532030
109mating behavior (GO:0007617)3.02359370
110vesicle transport along microtubule (GO:0047496)3.02212576
111learning (GO:0007612)3.00378695
112prepulse inhibition (GO:0060134)3.00070481
113intraspecies interaction between organisms (GO:0051703)2.99709189
114social behavior (GO:0035176)2.99709189
115synaptic transmission (GO:0007268)2.95778559
116neuromuscular process controlling posture (GO:0050884)2.95304477
117synapse organization (GO:0050808)2.94806263
118organelle transport along microtubule (GO:0072384)2.94568241
119positive regulation of dendritic spine development (GO:0060999)2.93244426
120fear response (GO:0042596)2.93019946
121negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.92662791
122regulation of dendritic spine development (GO:0060998)2.91979203
123glycine transport (GO:0015816)2.90552508
124regulation of synaptic transmission (GO:0050804)2.89569299
125central nervous system projection neuron axonogenesis (GO:0021952)2.89358127

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.96610513
2GBX2_23144817_ChIP-Seq_PC3_Human3.67939401
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.12310813
4* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.06391410
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.00005906
6REST_21632747_ChIP-Seq_MESCs_Mouse2.71445723
7* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.68428108
8* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.68428108
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.60815669
10* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.57573464
11* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.52324886
12* EZH2_27304074_Chip-Seq_ESCs_Mouse2.51828659
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.48942068
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.47603884
15* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.44964268
16DROSHA_22980978_ChIP-Seq_HELA_Human2.41141377
17RARB_27405468_Chip-Seq_BRAIN_Mouse2.31365618
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.24687258
19* EED_16625203_ChIP-ChIP_MESCs_Mouse2.23747338
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.22904473
21REST_18959480_ChIP-ChIP_MESCs_Mouse2.18266463
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.16449662
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.14560845
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.10131963
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.04736560
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.03895475
27AR_21572438_ChIP-Seq_LNCaP_Human1.93714733
28IKZF1_21737484_ChIP-ChIP_HCT116_Human1.93262917
29TAF15_26573619_Chip-Seq_HEK293_Human1.92449696
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.90476680
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.76272115
32RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.75995617
33SMAD4_21799915_ChIP-Seq_A2780_Human1.71444355
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.67736018
35EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65176987
36MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.61359192
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.58777137
38ZNF274_21170338_ChIP-Seq_K562_Hela1.55391106
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.53978070
40THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.46955153
41P300_19829295_ChIP-Seq_ESCs_Human1.46575745
42ERG_21242973_ChIP-ChIP_JURKAT_Human1.41318568
43SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38226149
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.38150618
45NR3C1_23031785_ChIP-Seq_PC12_Mouse1.37158175
46SOX2_21211035_ChIP-Seq_LN229_Gbm1.36211006
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.35570663
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35229691
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.35221943
50SMAD_19615063_ChIP-ChIP_OVARY_Human1.32752680
51RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32469668
52IGF1R_20145208_ChIP-Seq_DFB_Human1.31650157
53RING1B_27294783_Chip-Seq_ESCs_Mouse1.31293794
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28285253
55AR_25329375_ChIP-Seq_VCAP_Human1.27711373
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25606097
57STAT3_23295773_ChIP-Seq_U87_Human1.25056169
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.24463690
59GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23640426
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22970035
61RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.20846833
62ZFP281_18757296_ChIP-ChIP_E14_Mouse1.20394248
63AR_19668381_ChIP-Seq_PC3_Human1.19811796
64CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19025693
65POU3F2_20337985_ChIP-ChIP_501MEL_Human1.17374988
66RNF2_27304074_Chip-Seq_NSC_Mouse1.16209424
67TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15981332
68RING1B_27294783_Chip-Seq_NPCs_Mouse1.13622569
69TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12806033
70P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12495056
71FUS_26573619_Chip-Seq_HEK293_Human1.10279058
72AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10171027
73* TCF4_23295773_ChIP-Seq_U87_Human1.09677555
74WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08965891
75ARNT_22903824_ChIP-Seq_MCF-7_Human1.07841227
76YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06570437
77ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05242795
78AHR_22903824_ChIP-Seq_MCF-7_Human1.03431122
79DNAJC2_21179169_ChIP-ChIP_NT2_Human1.03284300
80PRDM14_20953172_ChIP-Seq_ESCs_Human1.03152944
81TET1_21490601_ChIP-Seq_MESCs_Mouse1.02870080
82GATA1_26923725_Chip-Seq_HPCs_Mouse1.02713381
83MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02528586
84RUNX2_22187159_ChIP-Seq_PCA_Human1.01462787
85UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98939668
86NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98486393
87OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.97484191
88SMAD3_21741376_ChIP-Seq_ESCs_Human0.97250354
89ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.97136920
90PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96512769
91ZFP281_27345836_Chip-Seq_ESCs_Mouse0.96487225
92POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95537423
93TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95537423
94WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.93655183
95CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93601035
96JUN_21703547_ChIP-Seq_K562_Human0.93349504
97ER_23166858_ChIP-Seq_MCF-7_Human0.93161643
98TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.92869852
99LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92449039
100TP53_16413492_ChIP-PET_HCT116_Human0.92031496
101TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91504895
102SMAD4_21741376_ChIP-Seq_HESCs_Human0.91451999
103CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.91426339
104KDM2B_26808549_Chip-Seq_K562_Human0.90367320
105VDR_22108803_ChIP-Seq_LS180_Human0.90265503
106TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.89810585
107SOX9_26525672_Chip-Seq_HEART_Mouse0.88176959
108TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.88071962
109* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88063795
110TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.87739034
111EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.86883184
112SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.86852764
113CTNNB1_20460455_ChIP-Seq_HCT116_Human0.86761194
114CTCF_27219007_Chip-Seq_Bcells_Human0.85432131
115NANOG_18555785_Chip-Seq_ESCs_Mouse0.83434298
116KDM2B_26808549_Chip-Seq_REH_Human0.83050154
117FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.82380311

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.17863515
2MP0003880_abnormal_central_pattern4.85382923
3MP0003635_abnormal_synaptic_transmissio4.09906734
4MP0004270_analgesia3.72492174
5MP0009745_abnormal_behavioral_response3.33077951
6MP0002063_abnormal_learning/memory/cond3.26522281
7MP0009046_muscle_twitch3.16478646
8MP0002064_seizures3.12719882
9MP0001968_abnormal_touch/_nociception3.09152532
10MP0005423_abnormal_somatic_nervous3.02953857
11MP0002572_abnormal_emotion/affect_behav2.80204403
12MP0002734_abnormal_mechanical_nocicepti2.77101958
13MP0002272_abnormal_nervous_system2.57075407
14MP0001486_abnormal_startle_reflex2.54584017
15MP0002735_abnormal_chemical_nociception2.50717195
16MP0002736_abnormal_nociception_after2.42357762
17MP0001440_abnormal_grooming_behavior2.28017437
18MP0001501_abnormal_sleep_pattern2.27945058
19MP0002733_abnormal_thermal_nociception2.17885940
20MP0002067_abnormal_sensory_capabilities2.06237094
21MP0002822_catalepsy2.05612927
22MP0006276_abnormal_autonomic_nervous2.04877195
23MP0001970_abnormal_pain_threshold2.04789927
24MP0000778_abnormal_nervous_system2.03110195
25MP0002184_abnormal_innervation2.00318707
26MP0003329_amyloid_beta_deposits1.88786637
27MP0005386_behavior/neurological_phenoty1.87039026
28MP0004924_abnormal_behavior1.87039026
29MP0008569_lethality_at_weaning1.82066112
30MP0002557_abnormal_social/conspecific_i1.81281267
31MP0004811_abnormal_neuron_physiology1.74898845
32MP0009780_abnormal_chondrocyte_physiolo1.74754949
33MP0004858_abnormal_nervous_system1.70796904
34MP0000955_abnormal_spinal_cord1.65271261
35MP0002909_abnormal_adrenal_gland1.63050474
36MP0001984_abnormal_olfaction1.61116362
37MP0002882_abnormal_neuron_morphology1.51525054
38MP0004885_abnormal_endolymph1.51279391
39MP0005646_abnormal_pituitary_gland1.44046035
40MP0002066_abnormal_motor_capabilities/c1.43715623
41MP0003879_abnormal_hair_cell1.41966925
42MP0003123_paternal_imprinting1.39430103
43MP0005645_abnormal_hypothalamus_physiol1.38277815
44MP0001529_abnormal_vocalization1.34978471
45MP0001905_abnormal_dopamine_level1.34864011
46MP0003787_abnormal_imprinting1.32492323
47MP0005551_abnormal_eye_electrophysiolog1.30740357
48MP0004142_abnormal_muscle_tone1.30128815
49MP0001502_abnormal_circadian_rhythm1.28215758
50MP0003122_maternal_imprinting1.27456681
51MP0003633_abnormal_nervous_system1.21324436
52MP0001188_hyperpigmentation1.15840235
53MP0002152_abnormal_brain_morphology1.15068219
54MP0008877_abnormal_DNA_methylation1.09989970
55MP0003631_nervous_system_phenotype1.08587653
56MP0002229_neurodegeneration1.06692698
57MP0004145_abnormal_muscle_electrophysio1.06092234
58MP0000569_abnormal_digit_pigmentation1.05976257
59MP0000751_myopathy1.05542742
60MP0004742_abnormal_vestibular_system1.05473219
61MP0004147_increased_porphyrin_level1.05284107
62MP0010386_abnormal_urinary_bladder0.95621035
63MP0008872_abnormal_physiological_respon0.93865098
64MP0002837_dystrophic_cardiac_calcinosis0.91762447
65MP0002069_abnormal_eating/drinking_beha0.91188735
66MP0002752_abnormal_somatic_nervous0.90904736
67MP0003121_genomic_imprinting0.90495029
68MP0005499_abnormal_olfactory_system0.90141072
69MP0005394_taste/olfaction_phenotype0.90141072
70MP0003634_abnormal_glial_cell0.89500903
71MP0001348_abnormal_lacrimal_gland0.87379620
72MP0001963_abnormal_hearing_physiology0.87146086
73MP0000631_abnormal_neuroendocrine_gland0.86797248
74MP0003632_abnormal_nervous_system0.86225863
75MP0006072_abnormal_retinal_apoptosis0.86197527
76MP0004085_abnormal_heartbeat0.84226705
77MP0004215_abnormal_myocardial_fiber0.80907430
78MP0001177_atelectasis0.80331215
79MP0005187_abnormal_penis_morphology0.78616076
80MP0000604_amyloidosis0.78345406
81MP0002090_abnormal_vision0.77865988
82MP0008874_decreased_physiological_sensi0.76596978
83MP0005535_abnormal_body_temperature0.76380540
84MP0000920_abnormal_myelination0.76080123
85MP0000013_abnormal_adipose_tissue0.74192983
86MP0001299_abnormal_eye_distance/0.73219612
87MP0001986_abnormal_taste_sensitivity0.72954266
88MP0002638_abnormal_pupillary_reflex0.70349543
89MP0003137_abnormal_impulse_conducting0.68361879
90MP0003690_abnormal_glial_cell0.68222371
91MP0004484_altered_response_of0.67615994
92MP0005409_darkened_coat_color0.65214421
93MP0004233_abnormal_muscle_weight0.65179995
94MP0003861_abnormal_nervous_system0.65099307
95MP0005253_abnormal_eye_physiology0.63340084
96MP0001346_abnormal_lacrimal_gland0.62438572
97MP0002876_abnormal_thyroid_physiology0.61684838
98MP0001485_abnormal_pinna_reflex0.60742225
99MP0008961_abnormal_basal_metabolism0.60347752
100MP0001943_abnormal_respiration0.58587273
101MP0010768_mortality/aging0.58570874
102MP0001664_abnormal_digestion0.57389536
103MP0005623_abnormal_meninges_morphology0.55859891
104MP0010769_abnormal_survival0.55334921
105MP0005167_abnormal_blood-brain_barrier0.54668621
106MP0010770_preweaning_lethality0.54637868
107MP0002082_postnatal_lethality0.54637868
108MP0003283_abnormal_digestive_organ0.54577137
109MP0000026_abnormal_inner_ear0.53297935
110MP0003956_abnormal_body_size0.52248513
111MP0004130_abnormal_muscle_cell0.44928021
112MP0003075_altered_response_to0.43657101

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.08270444
2Myokymia (HP:0002411)6.27381143
3Focal seizures (HP:0007359)5.54923101
4Visual hallucinations (HP:0002367)5.46258264
5Epileptic encephalopathy (HP:0200134)4.85009351
6Progressive cerebellar ataxia (HP:0002073)4.48989823
7Atonic seizures (HP:0010819)4.48392246
8Febrile seizures (HP:0002373)4.36728039
9Absence seizures (HP:0002121)4.11082596
10Generalized tonic-clonic seizures (HP:0002069)3.75556409
11Supranuclear gaze palsy (HP:0000605)3.75155681
12Action tremor (HP:0002345)3.73338157
13Dialeptic seizures (HP:0011146)3.72660261
14Broad-based gait (HP:0002136)3.66437977
15Mutism (HP:0002300)3.46276480
16Hyperventilation (HP:0002883)3.35016820
17Poor eye contact (HP:0000817)3.33671361
18Ankle clonus (HP:0011448)3.31495691
19Gaze-evoked nystagmus (HP:0000640)3.17105669
20Cerebral hypomyelination (HP:0006808)3.07204678
21Dysdiadochokinesis (HP:0002075)3.05597121
22Depression (HP:0000716)3.02472048
23Abnormal social behavior (HP:0012433)2.98128590
24Impaired social interactions (HP:0000735)2.98128590
25Limb dystonia (HP:0002451)2.98121110
26Truncal ataxia (HP:0002078)2.97849283
27Excessive salivation (HP:0003781)2.96929703
28Drooling (HP:0002307)2.96929703
29Urinary bladder sphincter dysfunction (HP:0002839)2.96535577
30Impaired vibration sensation in the lower limbs (HP:0002166)2.96333097
31Amblyopia (HP:0000646)2.96208091
32Papilledema (HP:0001085)2.93945546
33Dysmetria (HP:0001310)2.91062635
34Abnormal eating behavior (HP:0100738)2.90521969
35Cerebral inclusion bodies (HP:0100314)2.90422862
36Genetic anticipation (HP:0003743)2.89617315
37Progressive inability to walk (HP:0002505)2.86242478
38Neurofibrillary tangles (HP:0002185)2.86039941
39Anxiety (HP:0000739)2.84361766
40Annular pancreas (HP:0001734)2.82383480
41Abnormality of the corticospinal tract (HP:0002492)2.78785313
42Tetraplegia (HP:0002445)2.78677992
43Abnormality of binocular vision (HP:0011514)2.70026820
44Diplopia (HP:0000651)2.70026820
45Postural instability (HP:0002172)2.69229910
46Insidious onset (HP:0003587)2.60291608
47Termporal pattern (HP:0011008)2.60291608
48Hemiparesis (HP:0001269)2.59437775
49Sleep apnea (HP:0010535)2.58389159
50Pheochromocytoma (HP:0002666)2.57456967
51Urinary urgency (HP:0000012)2.54455499
52Spastic gait (HP:0002064)2.54027837
53Absent speech (HP:0001344)2.50533225
54Polyphagia (HP:0002591)2.49626575
55Epileptiform EEG discharges (HP:0011182)2.48627068
56Amyotrophic lateral sclerosis (HP:0007354)2.46788440
57Impaired smooth pursuit (HP:0007772)2.44864672
58EEG with generalized epileptiform discharges (HP:0011198)2.43070441
59Clonus (HP:0002169)2.40962611
60Inability to walk (HP:0002540)2.40383306
61Scanning speech (HP:0002168)2.39811252
62Bradykinesia (HP:0002067)2.37719916
63Abnormality of the lower motor neuron (HP:0002366)2.37694562
64Fetal akinesia sequence (HP:0001989)2.36874764
65Peripheral hypomyelination (HP:0007182)2.31947246
66Agitation (HP:0000713)2.30831817
67Hypsarrhythmia (HP:0002521)2.29429359
68Torticollis (HP:0000473)2.28707325
69Intention tremor (HP:0002080)2.28282824
70Stereotypic behavior (HP:0000733)2.27153956
71Apathy (HP:0000741)2.23579834
72Spastic tetraparesis (HP:0001285)2.22603594
73Neuroendocrine neoplasm (HP:0100634)2.21114843
74Megalencephaly (HP:0001355)2.18300082
75Lower limb muscle weakness (HP:0007340)2.18147236
76Abnormality of ocular smooth pursuit (HP:0000617)2.17991975
77Hypoventilation (HP:0002791)2.16380058
78Focal dystonia (HP:0004373)2.13566558
79Rigidity (HP:0002063)2.12096938
80Ventricular fibrillation (HP:0001663)2.11084351
81Akinesia (HP:0002304)2.09919729
82Inappropriate behavior (HP:0000719)2.09237876
83Generalized myoclonic seizures (HP:0002123)2.08984339
84CNS hypomyelination (HP:0003429)2.07136150
85Hemiplegia (HP:0002301)2.06967677
86Status epilepticus (HP:0002133)2.03604968
87Diminished motivation (HP:0000745)2.01620957
88Abnormality of salivation (HP:0100755)2.01163983
89Choreoathetosis (HP:0001266)1.98752985
90Dysmetric saccades (HP:0000641)1.98291363
91Rapidly progressive (HP:0003678)1.97296547
92Spastic tetraplegia (HP:0002510)1.96528827
93Blue irides (HP:0000635)1.96343802
94Gait imbalance (HP:0002141)1.94633780
95Impaired vibratory sensation (HP:0002495)1.92853250
96Craniofacial dystonia (HP:0012179)1.87834514
97Neuronal loss in central nervous system (HP:0002529)1.86735988
98Aqueductal stenosis (HP:0002410)1.84974753
99Aplasia/Hypoplasia of the brainstem (HP:0007362)1.84358244
100Hypoplasia of the brainstem (HP:0002365)1.84358244
101Gait ataxia (HP:0002066)1.83194333
102Morphological abnormality of the pyramidal tract (HP:0002062)1.81347537
103Degeneration of the lateral corticospinal tracts (HP:0002314)1.80543328
104Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.80543328
105Specific learning disability (HP:0001328)1.80186810
106Obstructive sleep apnea (HP:0002870)1.80174325
107Psychosis (HP:0000709)1.80171842
108Increased circulating renin level (HP:0000848)1.79326068
109Central scotoma (HP:0000603)1.79207539
110Incomplete penetrance (HP:0003829)1.79114987
111Lower limb asymmetry (HP:0100559)1.78505140
112Protruding tongue (HP:0010808)1.78163350
113Insomnia (HP:0100785)1.77596735
114Delusions (HP:0000746)1.77436737
115Failure to thrive in infancy (HP:0001531)1.76574037
116Paraplegia (HP:0010550)1.74548876
117Abnormality of saccadic eye movements (HP:0000570)1.74240869
118Hyperthyroidism (HP:0000836)1.73906436
119Bundle branch block (HP:0011710)1.71294017
120Prolonged QT interval (HP:0001657)1.70275731
121Hypoplasia of the corpus callosum (HP:0002079)1.68990458

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.25202220
2NTRK34.07497891
3MAP3K93.88784584
4EPHA43.41656308
5MAP3K43.29970581
6MINK12.81612578
7MAP2K72.74996960
8PAK62.30219594
9DAPK22.23250310
10NTRK22.19151255
11MAP3K122.16250563
12CASK2.14921279
13MAP2K41.99703297
14PNCK1.94401725
15KSR21.89490051
16NTRK11.86165489
17RIPK41.71605932
18PLK21.65222781
19CAMKK11.60853236
20MAPK131.58180126
21GRK51.57251159
22KSR11.55756048
23CDK51.54665038
24TNIK1.47503029
25SIK21.44647033
26LATS21.37317429
27PHKG11.36364147
28PHKG21.36364147
29PRKD31.33251623
30DAPK11.32046657
31CDK191.29442969
32PRKCG1.21134216
33UHMK11.18215200
34STK381.17612638
35PRPF4B1.12073197
36ARAF1.11777802
37MAP3K21.07672608
38CAMKK21.07606024
39RIPK11.05310268
40CAMK2A1.03231698
41FES0.99821676
42CSNK1G20.99150842
43CDK180.91820656
44CDK150.90361636
45CDK140.89709834
46RET0.86822470
47STK110.85998470
48TYRO30.84869954
49CAMK10.83671378
50PAK30.83379657
51DYRK1A0.83283176
52SGK2230.82406005
53SGK4940.82406005
54OXSR10.81403850
55MAP3K130.80513606
56CDK11A0.78480786
57CAMK2B0.77056011
58NEK60.74640308
59PRKCH0.70083632
60BMPR20.68781059
61TAOK10.68583213
62MARK20.67506032
63RAF10.66520795
64CAMK1G0.64661038
65SGK10.63594447
66PTK2B0.62969999
67SGK20.62451348
68NME10.61647967
69LMTK20.60602517
70ALK0.58463507
71PRKCE0.57800204
72PRKCZ0.56758966
73LIMK10.55129987
74PINK10.54770985
75CAMK2D0.54324003
76FGR0.51234642
77MAP3K60.51161534
78CCNB10.50934711
79DYRK20.49585433
80SGK30.48581583
81SCYL20.48474450
82PDK10.48269317
83WNK10.47609888
84ERBB30.47183243
85PKN10.46741482
86CSNK1G30.45551780
87RPS6KA30.45208937
88FYN0.44876652
89WNK30.44207433
90PDPK10.44013978
91FER0.43730738
92MAPK120.43486226
93BRSK10.43468147
94MAP3K10.42930128
95CAMK2G0.42743296
96CDC42BPA0.41864232
97BRAF0.41745168
98MAPK100.40958051
99TNK20.40343548
100ROCK20.40116370
101MAP3K110.40085102
102MAP2K10.39349583
103FGFR20.38764669
104RPS6KA20.36432316
105TESK10.35643731
106BCR0.35195824
107CAMK40.34488138
108PRKCA0.33993283
109PRKG10.33537972
110CSNK1D0.33007061
111CSNK1E0.32216635
112MAPKAPK50.31952466
113PRKACA0.31810651
114DAPK30.30622868
115PRKCB0.29824239
116CSNK1A1L0.29475233

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.81674133
2Synaptic vesicle cycle_Homo sapiens_hsa047213.44177176
3GABAergic synapse_Homo sapiens_hsa047272.76615759
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.74443801
5Circadian entrainment_Homo sapiens_hsa047132.65233450
6Long-term potentiation_Homo sapiens_hsa047202.61607493
7Glutamatergic synapse_Homo sapiens_hsa047242.60058055
8Olfactory transduction_Homo sapiens_hsa047402.58279833
9Morphine addiction_Homo sapiens_hsa050322.47713324
10Amphetamine addiction_Homo sapiens_hsa050312.38881833
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.23157670
12Dopaminergic synapse_Homo sapiens_hsa047282.20046353
13Salivary secretion_Homo sapiens_hsa049702.11308098
14Insulin secretion_Homo sapiens_hsa049111.92212666
15Cholinergic synapse_Homo sapiens_hsa047251.91064458
16Gastric acid secretion_Homo sapiens_hsa049711.83360892
17Taste transduction_Homo sapiens_hsa047421.82745079
18Serotonergic synapse_Homo sapiens_hsa047261.78746123
19Long-term depression_Homo sapiens_hsa047301.77311172
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.75235400
21Renin secretion_Homo sapiens_hsa049241.70286518
22Cocaine addiction_Homo sapiens_hsa050301.65143387
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.63486924
24Oxytocin signaling pathway_Homo sapiens_hsa049211.60934268
25Collecting duct acid secretion_Homo sapiens_hsa049661.60734685
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.50732332
27Calcium signaling pathway_Homo sapiens_hsa040201.50475855
28Phototransduction_Homo sapiens_hsa047441.48001607
29GnRH signaling pathway_Homo sapiens_hsa049121.44738738
30Gap junction_Homo sapiens_hsa045401.37279713
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.29391236
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.28896044
33Axon guidance_Homo sapiens_hsa043601.26624610
34cAMP signaling pathway_Homo sapiens_hsa040241.22313191
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.21695801
36Cardiac muscle contraction_Homo sapiens_hsa042601.17095502
37Estrogen signaling pathway_Homo sapiens_hsa049151.16182180
38Vitamin B6 metabolism_Homo sapiens_hsa007501.15687930
39Type II diabetes mellitus_Homo sapiens_hsa049301.12707655
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.11331890
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.07713466
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.07477907
43Glioma_Homo sapiens_hsa052141.06359250
44ErbB signaling pathway_Homo sapiens_hsa040121.04910837
45Vibrio cholerae infection_Homo sapiens_hsa051101.04565928
46Melanogenesis_Homo sapiens_hsa049161.03302438
47cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00518689
48Oocyte meiosis_Homo sapiens_hsa041140.89290905
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.87697532
50Dorso-ventral axis formation_Homo sapiens_hsa043200.84013839
51Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79420966
52Phospholipase D signaling pathway_Homo sapiens_hsa040720.79010788
53Pancreatic secretion_Homo sapiens_hsa049720.78912361
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74821528
55Dilated cardiomyopathy_Homo sapiens_hsa054140.73822721
56Thyroid hormone synthesis_Homo sapiens_hsa049180.72465359
57Choline metabolism in cancer_Homo sapiens_hsa052310.71781598
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71533604
59MAPK signaling pathway_Homo sapiens_hsa040100.69789892
60Alzheimers disease_Homo sapiens_hsa050100.65651582
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65407605
62Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.62921122
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.62288900
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60326796
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.59488047
66Ras signaling pathway_Homo sapiens_hsa040140.59197353
67VEGF signaling pathway_Homo sapiens_hsa043700.56976560
68Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54015801
69Glucagon signaling pathway_Homo sapiens_hsa049220.52635195
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.52583515
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51810644
72Alcoholism_Homo sapiens_hsa050340.51709561
73Oxidative phosphorylation_Homo sapiens_hsa001900.50786167
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50068129
75Renal cell carcinoma_Homo sapiens_hsa052110.49034916
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49018912
77Rap1 signaling pathway_Homo sapiens_hsa040150.48982162
78Endometrial cancer_Homo sapiens_hsa052130.48824026
79Wnt signaling pathway_Homo sapiens_hsa043100.47367525
80mTOR signaling pathway_Homo sapiens_hsa041500.45497609
81Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44721362
82Inositol phosphate metabolism_Homo sapiens_hsa005620.44604149
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43396639
84Type I diabetes mellitus_Homo sapiens_hsa049400.43342815
85Endocytosis_Homo sapiens_hsa041440.43106115
86Bile secretion_Homo sapiens_hsa049760.39690755
87Parkinsons disease_Homo sapiens_hsa050120.39391108
88Fatty acid biosynthesis_Homo sapiens_hsa000610.38427134
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38219555
90Insulin signaling pathway_Homo sapiens_hsa049100.37808366
91Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.37661292
92Ovarian steroidogenesis_Homo sapiens_hsa049130.37488964
93Prion diseases_Homo sapiens_hsa050200.37174971
94Circadian rhythm_Homo sapiens_hsa047100.36112380
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34840278
96African trypanosomiasis_Homo sapiens_hsa051430.34657609
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34622519
98Mineral absorption_Homo sapiens_hsa049780.34515598
99Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33439466
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33183289
101Colorectal cancer_Homo sapiens_hsa052100.32488462
102Non-small cell lung cancer_Homo sapiens_hsa052230.32228041
103Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31476744
104Nitrogen metabolism_Homo sapiens_hsa009100.30384483
105Arginine biosynthesis_Homo sapiens_hsa002200.28617713
106AMPK signaling pathway_Homo sapiens_hsa041520.25966617
107Butanoate metabolism_Homo sapiens_hsa006500.25341547
108Arginine and proline metabolism_Homo sapiens_hsa003300.24345146
109Tight junction_Homo sapiens_hsa045300.23703813
110Regulation of autophagy_Homo sapiens_hsa041400.23526490
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.22666125
112Histidine metabolism_Homo sapiens_hsa003400.21031250
113Hippo signaling pathway_Homo sapiens_hsa043900.17953732

Most similar genes based on co-expression Upload to Enrichr

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