SNAPC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)4.64966159
2maturation of 5.8S rRNA (GO:0000460)4.58275962
3regulation of synaptic vesicle exocytosis (GO:2000300)4.56015071
4proteasome assembly (GO:0043248)4.52360616
5regulation of short-term neuronal synaptic plasticity (GO:0048172)4.51679222
6synapsis (GO:0007129)4.19857104
7chromatin remodeling at centromere (GO:0031055)4.02867439
8CENP-A containing nucleosome assembly (GO:0034080)4.02144338
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.01263496
10synaptic vesicle maturation (GO:0016188)3.99304557
11regulation of synaptic vesicle transport (GO:1902803)3.93408126
12protein localization to synapse (GO:0035418)3.91524465
13glutamate secretion (GO:0014047)3.89340307
14neuron cell-cell adhesion (GO:0007158)3.80839404
15neuronal action potential propagation (GO:0019227)3.73815630
16histone exchange (GO:0043486)3.67692247
17platelet dense granule organization (GO:0060155)3.63615838
18protein K6-linked ubiquitination (GO:0085020)3.63281331
19DNA double-strand break processing (GO:0000729)3.55724523
20neuromuscular process controlling posture (GO:0050884)3.54447596
21establishment of protein localization to mitochondrial membrane (GO:0090151)3.48186270
22replication fork processing (GO:0031297)3.43873533
23nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.43477086
24startle response (GO:0001964)3.41472843
25DNA deamination (GO:0045006)3.37845674
26resolution of meiotic recombination intermediates (GO:0000712)3.36518619
27kinetochore organization (GO:0051383)3.34875962
28positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.34695681
29exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.33328255
30regulation of DNA endoreduplication (GO:0032875)3.28941543
31vocalization behavior (GO:0071625)3.26937308
32protein-cofactor linkage (GO:0018065)3.26509402
33peptidyl-arginine omega-N-methylation (GO:0035247)3.25139134
34transcription elongation from RNA polymerase III promoter (GO:0006385)3.24717928
35termination of RNA polymerase III transcription (GO:0006386)3.24717928
36synaptic vesicle docking involved in exocytosis (GO:0016081)3.24168523
37neurotransmitter secretion (GO:0007269)3.23537570
38male meiosis I (GO:0007141)3.18028327
39secondary heart field specification (GO:0003139)3.17210411
40heart field specification (GO:0003128)3.17210411
41peptidyl-arginine N-methylation (GO:0035246)3.13433311
42peptidyl-arginine methylation (GO:0018216)3.13433311
43recombinational repair (GO:0000725)3.12433353
44metaphase plate congression (GO:0051310)3.10940951
45double-strand break repair via homologous recombination (GO:0000724)3.09740809
46protein complex biogenesis (GO:0070271)3.09667151
47regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.08279286
48meiotic chromosome segregation (GO:0045132)3.07892997
49DNA replication checkpoint (GO:0000076)3.07299879
50mitochondrial respiratory chain complex assembly (GO:0033108)3.05238827
51ribosome assembly (GO:0042255)3.04487525
52mitochondrial respiratory chain complex I assembly (GO:0032981)3.04034699
53NADH dehydrogenase complex assembly (GO:0010257)3.04034699
54mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.04034699
55gamma-aminobutyric acid signaling pathway (GO:0007214)3.03899586
56kinetochore assembly (GO:0051382)3.02081407
57negative regulation of telomere maintenance (GO:0032205)3.01668085
58locomotory exploration behavior (GO:0035641)3.00313601
59mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.00293271
60chromosome organization involved in meiosis (GO:0070192)3.00249223
61nucleotide transmembrane transport (GO:1901679)2.97895239
62regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.96844810
63negative regulation of meiosis (GO:0045835)2.95264882
64negative regulation of DNA-dependent DNA replication (GO:2000104)2.94612038
65attachment of spindle microtubules to kinetochore (GO:0008608)2.94427198
66DNA methylation involved in gamete generation (GO:0043046)2.92443428
67righting reflex (GO:0060013)2.90529831
68RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.89056207
69RNA capping (GO:0036260)2.86963659
707-methylguanosine RNA capping (GO:0009452)2.86963659
71epithelial cilium movement (GO:0003351)2.85902176
72response to X-ray (GO:0010165)2.85700618
73meiosis I (GO:0007127)2.85081479
74regulation of translational termination (GO:0006449)2.84110670
75rRNA modification (GO:0000154)2.84103355
76protein neddylation (GO:0045116)2.83190277
77intraciliary transport (GO:0042073)2.82324549
78histone arginine methylation (GO:0034969)2.81650255
79intracellular protein transmembrane import (GO:0044743)2.79166377
80regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.77945916
81regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.77720757
82regulation of mitotic spindle checkpoint (GO:1903504)2.77720757
83lactate metabolic process (GO:0006089)2.77372642
84negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.77363813
85rRNA methylation (GO:0031167)2.76950858
86histone mRNA metabolic process (GO:0008334)2.76733427
87regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.75947484
88centriole replication (GO:0007099)2.75345973
89innervation (GO:0060384)2.74421349
90protein deneddylation (GO:0000338)2.74025161
91regulation of vesicle fusion (GO:0031338)2.73719005
92regulation of glutamate receptor signaling pathway (GO:1900449)2.72874513
93spliceosomal snRNP assembly (GO:0000387)2.72840249
94positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.72517617
95maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.72435016
96tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.72027162
97RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.72027162
98anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.71861125
99DNA replication-independent nucleosome organization (GO:0034724)2.71444070
100DNA replication-independent nucleosome assembly (GO:0006336)2.71444070
101rRNA catabolic process (GO:0016075)2.70817065
102cilium morphogenesis (GO:0060271)2.70007696
103DNA catabolic process, exonucleolytic (GO:0000738)2.69554151
104regulation of meiosis I (GO:0060631)2.68032298
105mitochondrion transport along microtubule (GO:0047497)2.66991061
106establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.66991061
107peptidyl-histidine modification (GO:0018202)2.66484690
108piRNA metabolic process (GO:0034587)2.66367604
109establishment of mitochondrion localization (GO:0051654)2.66267766
110cullin deneddylation (GO:0010388)2.64609734
111pseudouridine synthesis (GO:0001522)2.63080845
112cerebellar Purkinje cell differentiation (GO:0021702)2.62488129
113transmission of nerve impulse (GO:0019226)2.61783202
114reciprocal meiotic recombination (GO:0007131)2.60512143
115reciprocal DNA recombination (GO:0035825)2.60512143
116positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.59985564
117cellular potassium ion homeostasis (GO:0030007)2.59900367
118long-term synaptic potentiation (GO:0060291)2.57899195
119mannosylation (GO:0097502)2.57622821
120long-term memory (GO:0007616)2.56731244
121neurotransmitter-gated ion channel clustering (GO:0072578)2.56667589
122neuron-neuron synaptic transmission (GO:0007270)2.56160309
123neurotransmitter transport (GO:0006836)2.56033778
124microtubule depolymerization (GO:0007019)2.55717806
125synaptic transmission, glutamatergic (GO:0035249)2.55564901
126activation of protein kinase A activity (GO:0034199)2.54950712
127protein localization to kinetochore (GO:0034501)2.54492375
128regulation of neurotransmitter secretion (GO:0046928)2.54390197
129microtubule anchoring (GO:0034453)2.54258139
130DNA replication-dependent nucleosome organization (GO:0034723)2.53470895
131DNA replication-dependent nucleosome assembly (GO:0006335)2.53470895
132negative regulation of synaptic transmission, GABAergic (GO:0032229)2.53217437
133UDP-N-acetylglucosamine metabolic process (GO:0006047)2.52669676
134spindle checkpoint (GO:0031577)2.52432868
135positive regulation of synapse maturation (GO:0090129)2.52262348
136regulation of telomere maintenance (GO:0032204)2.52242699
137regulation of neuronal synaptic plasticity (GO:0048168)2.51349036
138regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.51255633
139meiotic cell cycle process (GO:1903046)2.51008729
140negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.50947840
141negative regulation of ligase activity (GO:0051352)2.50947840
142transcription elongation from RNA polymerase I promoter (GO:0006362)2.49553741
143regulation of centriole replication (GO:0046599)2.49495373
144mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.49359410
145L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.49203591
146regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.48322315
147chaperone-mediated protein transport (GO:0072321)2.47876812
148termination of RNA polymerase I transcription (GO:0006363)2.47361009
149purine nucleobase biosynthetic process (GO:0009113)2.46329203
150positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.43829174
151nucleobase biosynthetic process (GO:0046112)2.43725534
152negative regulation of calcium ion transport into cytosol (GO:0010523)2.41828674
153regulation of neurotransmitter transport (GO:0051588)2.38889323
154response to auditory stimulus (GO:0010996)2.38724522
155regulation of clathrin-mediated endocytosis (GO:2000369)2.36800807
156positive regulation of membrane potential (GO:0045838)2.35397062
157regulation of axon regeneration (GO:0048679)2.35347157
158regulation of neuron projection regeneration (GO:0070570)2.35347157
159establishment of synaptic vesicle localization (GO:0097480)2.35189873
160synaptic vesicle transport (GO:0048489)2.35189873
161mitotic metaphase plate congression (GO:0007080)2.34020402
162male meiosis (GO:0007140)2.33950796
163striatum development (GO:0021756)2.32984026
164synaptic vesicle endocytosis (GO:0048488)2.32865641
165positive regulation of dendritic spine morphogenesis (GO:0061003)2.32083677
166layer formation in cerebral cortex (GO:0021819)2.30623966
167ionotropic glutamate receptor signaling pathway (GO:0035235)2.30054473
168transferrin transport (GO:0033572)2.28634745
169regulation of meiosis (GO:0040020)2.28282242
170organelle transport along microtubule (GO:0072384)2.28256712
171membrane hyperpolarization (GO:0060081)2.27996044
172positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.27917995
173mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.27699287
174regulation of long-term neuronal synaptic plasticity (GO:0048169)2.26996495
175glutamate receptor signaling pathway (GO:0007215)2.26864536
176establishment of vesicle localization (GO:0051650)2.25702507
177negative regulation of meiotic cell cycle (GO:0051447)2.25454791
178neurofilament cytoskeleton organization (GO:0060052)2.25397207
179activated T cell proliferation (GO:0050798)2.23916022
180response to histamine (GO:0034776)2.23752948
181positive regulation of synapse assembly (GO:0051965)2.23222950
182exploration behavior (GO:0035640)2.23080471
183regulation of cAMP-dependent protein kinase activity (GO:2000479)2.23070310
184negative regulation of dendrite morphogenesis (GO:0050774)2.22417886
185presynaptic membrane assembly (GO:0097105)2.22106632
186neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.20917172
187specification of organ identity (GO:0010092)2.20891027
188regulation of synaptic plasticity (GO:0048167)2.19571910
189regulation of synaptic transmission, glutamatergic (GO:0051966)2.19306946
190regulation of postsynaptic membrane potential (GO:0060078)2.19235380
191regulation of neurotransmitter levels (GO:0001505)2.17424846
192protein polyglutamylation (GO:0018095)2.13638450
193postsynaptic membrane organization (GO:0001941)2.12864805

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.42184387
2GBX2_23144817_ChIP-Seq_PC3_Human3.44082276
3IGF1R_20145208_ChIP-Seq_DFB_Human3.27085508
4SMAD_19615063_ChIP-ChIP_OVARY_Human3.17370160
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.14963837
6TAF15_26573619_Chip-Seq_HEK293_Human2.87827801
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.53139256
8E2F7_22180533_ChIP-Seq_HELA_Human2.52249209
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.50631745
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.36776678
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.16437969
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.13138884
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.12118245
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.10610861
15NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.07179643
16REST_21632747_ChIP-Seq_MESCs_Mouse2.07081917
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.02238257
18CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.01189948
19ZFP57_27257070_Chip-Seq_ESCs_Mouse1.97563158
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.91053687
21NOTCH1_21737748_ChIP-Seq_TLL_Human1.89720560
22REST_18959480_ChIP-ChIP_MESCs_Mouse1.87808411
23MYC_18940864_ChIP-ChIP_HL60_Human1.78966888
24RARB_27405468_Chip-Seq_BRAIN_Mouse1.74920899
25* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.72926573
26AR_21572438_ChIP-Seq_LNCaP_Human1.72553413
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.71490409
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.63469189
29FOXP3_21729870_ChIP-Seq_TREG_Human1.63003718
30BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.62711681
31RNF2_27304074_Chip-Seq_NSC_Mouse1.62389541
32SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.61021780
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.60452217
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59956834
35SMAD4_21799915_ChIP-Seq_A2780_Human1.58539878
36MYC_18555785_ChIP-Seq_MESCs_Mouse1.56975697
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.55249645
38JARID2_20064375_ChIP-Seq_MESCs_Mouse1.54672770
39RBPJ_22232070_ChIP-Seq_NCS_Mouse1.54300828
40FUS_26573619_Chip-Seq_HEK293_Human1.53631857
41DCP1A_22483619_ChIP-Seq_HELA_Human1.50974803
42CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.49571436
43HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.46192836
44P300_19829295_ChIP-Seq_ESCs_Human1.45210833
45* SRF_21415370_ChIP-Seq_HL-1_Mouse1.44537993
46GABP_17652178_ChIP-ChIP_JURKAT_Human1.43628989
47ER_23166858_ChIP-Seq_MCF-7_Human1.43348732
48STAT3_23295773_ChIP-Seq_U87_Human1.42774299
49JUN_21703547_ChIP-Seq_K562_Human1.39027524
50HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.36063430
51EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.35920839
52KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.34341988
53NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.31828199
54YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30473591
55IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30249048
56CBP_20019798_ChIP-Seq_JUKART_Human1.30249048
57ZNF274_21170338_ChIP-Seq_K562_Hela1.29934432
58MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29203900
59* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.28305958
60* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27962381
61SALL1_21062744_ChIP-ChIP_HESCs_Human1.24709597
62SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.23414384
63SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.21991807
64ELK1_22589737_ChIP-Seq_MCF10A_Human1.21749861
65KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.20044208
66* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19202070
67EWS_26573619_Chip-Seq_HEK293_Human1.19088841
68UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18791479
69MYC_19030024_ChIP-ChIP_MESCs_Mouse1.16731273
70SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.16234940
71PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.16178116
72* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.15882792
73AR_21909140_ChIP-Seq_LNCAP_Human1.15784990
74EST1_17652178_ChIP-ChIP_JURKAT_Human1.15254318
75POU5F1_16153702_ChIP-ChIP_HESCs_Human1.15114783
76BCAT_22108803_ChIP-Seq_LS180_Human1.14559154
77PRDM14_20953172_ChIP-Seq_ESCs_Human1.14312368
78* TCF4_23295773_ChIP-Seq_U87_Human1.13567672
79* AR_25329375_ChIP-Seq_VCAP_Human1.12992155
80PCGF2_27294783_Chip-Seq_ESCs_Mouse1.10777473
81TTF2_22483619_ChIP-Seq_HELA_Human1.10182882
82* NANOG_19829295_ChIP-Seq_ESCs_Human1.10083852
83* SOX2_19829295_ChIP-Seq_ESCs_Human1.10083852
84EZH2_27294783_Chip-Seq_NPCs_Mouse1.09981960
85THAP11_20581084_ChIP-Seq_MESCs_Mouse1.09500846
86FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.09362426
87E2F1_18555785_ChIP-Seq_MESCs_Mouse1.08920146
88* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08534038
89BMI1_23680149_ChIP-Seq_NPCS_Mouse1.08108088
90RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07858728
91BRD4_25478319_ChIP-Seq_HGPS_Human1.07748036
92PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.06934388
93JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.06785420
94E2F1_21310950_ChIP-Seq_MCF-7_Human1.06530581
95MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.05029904
96MTF2_20144788_ChIP-Seq_MESCs_Mouse1.04486198
97P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03787978
98SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.03387926
99ELK1_19687146_ChIP-ChIP_HELA_Human1.02657194
100KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02582557
101TP53_22573176_ChIP-Seq_HFKS_Human1.02562376
102CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.02148293
103EZH2_18974828_ChIP-Seq_MESCs_Mouse1.01371314
104RNF2_18974828_ChIP-Seq_MESCs_Mouse1.01371314
105* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00714925
106* FOXA1_25329375_ChIP-Seq_VCAP_Human1.00714925
107ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00519699
108* SOX2_21211035_ChIP-Seq_LN229_Gbm1.00439465
109SMAD3_21741376_ChIP-Seq_EPCs_Human1.00196774
110E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.99958033
111CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99886460
112TCF4_22108803_ChIP-Seq_LS180_Human0.98594277
113HOXB4_20404135_ChIP-ChIP_EML_Mouse0.98163338
114NANOG_16153702_ChIP-ChIP_HESCs_Human0.97390937
115* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.97071954
116IKZF1_21737484_ChIP-ChIP_HCT116_Human0.96176950
117TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94970440
118TP63_19390658_ChIP-ChIP_HaCaT_Human0.94841122
119AR_20517297_ChIP-Seq_VCAP_Human0.94058989
120SUZ12_27294783_Chip-Seq_NPCs_Mouse0.93811797
121IRF1_19129219_ChIP-ChIP_H3396_Human0.93699550
122VDR_23849224_ChIP-Seq_CD4+_Human0.93568081
123ELF1_17652178_ChIP-ChIP_JURKAT_Human0.93430813
124* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.93101500
125SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93089227
126NANOG_18555785_Chip-Seq_ESCs_Mouse0.92960697
127E2F4_17652178_ChIP-ChIP_JURKAT_Human0.92928459
128ETS1_20019798_ChIP-Seq_JURKAT_Human0.92573274
129PIAS1_25552417_ChIP-Seq_VCAP_Human0.92026403
130FOXM1_26456572_ChIP-Seq_MCF-7_Human0.92009322
131* NELFA_20434984_ChIP-Seq_ESCs_Mouse0.91768653
132SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.91662192
133* CDX2_22108803_ChIP-Seq_LS180_Human0.91459916
134AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91013571
135FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.90871159
136REST_19997604_ChIP-ChIP_NEURONS_Mouse0.90564474
137GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.90453166
138EZH2_27304074_Chip-Seq_ESCs_Mouse0.89976565
139CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.89782254
140PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89232750
141MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.88714409
142MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.87611063
143CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.85340080
144GABP_19822575_ChIP-Seq_HepG2_Human0.84098847
145TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.84009557
146DROSHA_22980978_ChIP-Seq_HELA_Human0.83439197
147MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.82949130
148VDR_22108803_ChIP-Seq_LS180_Human0.82685064
149SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.82375016
150SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.82173005
151RNF2_27304074_Chip-Seq_ESCs_Mouse0.81674234

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.20971665
2MP0003950_abnormal_plasma_membrane4.04188170
3MP0003880_abnormal_central_pattern3.98183815
4MP0008877_abnormal_DNA_methylation3.01368264
5MP0001968_abnormal_touch/_nociception2.91581574
6MP0003635_abnormal_synaptic_transmissio2.90021531
7MP0005423_abnormal_somatic_nervous2.82848015
8MP0004270_analgesia2.78411063
9MP0009046_muscle_twitch2.61182296
10MP0009697_abnormal_copulation2.61067933
11MP0002254_reproductive_system_inflammat2.56446936
12MP0002734_abnormal_mechanical_nocicepti2.47965875
13MP0002064_seizures2.37954038
14MP0002736_abnormal_nociception_after2.37538847
15MP0006292_abnormal_olfactory_placode2.36069976
16MP0006276_abnormal_autonomic_nervous2.33433040
17MP0009745_abnormal_behavioral_response2.30922886
18MP0002063_abnormal_learning/memory/cond2.23863042
19MP0003136_yellow_coat_color2.19186228
20MP0003787_abnormal_imprinting2.17876053
21MP0001529_abnormal_vocalization2.12710916
22MP0006054_spinal_hemorrhage2.07996917
23MP0003806_abnormal_nucleotide_metabolis2.07875969
24MP0001501_abnormal_sleep_pattern2.05944407
25MP0002572_abnormal_emotion/affect_behav2.02968037
26MP0002938_white_spotting2.01959218
27MP0002735_abnormal_chemical_nociception2.00495389
28MP0002272_abnormal_nervous_system1.98120904
29MP0003786_premature_aging1.97843384
30MP0002837_dystrophic_cardiac_calcinosis1.89645560
31MP0000372_irregular_coat_pigmentation1.87724979
32MP0001970_abnormal_pain_threshold1.85928085
33MP0002160_abnormal_reproductive_system1.81580775
34MP0003123_paternal_imprinting1.76076219
35MP0010030_abnormal_orbit_morphology1.75367381
36MP0002067_abnormal_sensory_capabilities1.72266470
37MP0002733_abnormal_thermal_nociception1.70655524
38MP0003122_maternal_imprinting1.69381482
39MP0010386_abnormal_urinary_bladder1.68826556
40MP0008007_abnormal_cellular_replicative1.63747138
41MP0004142_abnormal_muscle_tone1.63280182
42MP0005646_abnormal_pituitary_gland1.60640346
43MP0002234_abnormal_pharynx_morphology1.60122300
44MP0003186_abnormal_redox_activity1.59855797
45MP0001293_anophthalmia1.58682988
46MP0002184_abnormal_innervation1.55137291
47MP0003121_genomic_imprinting1.53970677
48MP0003195_calcinosis1.53902766
49MP0001486_abnormal_startle_reflex1.53546965
50MP0001984_abnormal_olfaction1.53380139
51MP0003937_abnormal_limbs/digits/tail_de1.52868966
52MP0004924_abnormal_behavior1.51223837
53MP0005386_behavior/neurological_phenoty1.51223837
54MP0008260_abnormal_autophagy1.50315762
55MP0005410_abnormal_fertilization1.48589874
56MP0004811_abnormal_neuron_physiology1.44948656
57MP0002557_abnormal_social/conspecific_i1.44280154
58MP0001440_abnormal_grooming_behavior1.43297888
59MP0005389_reproductive_system_phenotype1.42933526
60MP0001986_abnormal_taste_sensitivity1.36300878
61MP0005395_other_phenotype1.34785453
62MP0010094_abnormal_chromosome_stability1.34286554
63MP0001502_abnormal_circadian_rhythm1.31925164
64MP0002282_abnormal_trachea_morphology1.30502943
65MP0000427_abnormal_hair_cycle1.27705900
66MP0008569_lethality_at_weaning1.26396475
67MP0001905_abnormal_dopamine_level1.26222553
68MP0005084_abnormal_gallbladder_morpholo1.25714466
69MP0005645_abnormal_hypothalamus_physiol1.23707704
70MP0000647_abnormal_sebaceous_gland1.21602766
71MP0003763_abnormal_thymus_physiology1.20040271
72MP0003693_abnormal_embryo_hatching1.18813488
73MP0001188_hyperpigmentation1.17217178
74MP0002277_abnormal_respiratory_mucosa1.14675270
75MP0000778_abnormal_nervous_system1.13928103
76MP0002653_abnormal_ependyma_morphology1.13767284
77MP0004215_abnormal_myocardial_fiber1.12920745
78MP0000749_muscle_degeneration1.12266976
79MP0001119_abnormal_female_reproductive1.12002613
80MP0002882_abnormal_neuron_morphology1.11952238
81MP0008932_abnormal_embryonic_tissue1.10073336
82MP0003890_abnormal_embryonic-extraembry1.10000543
83MP0002638_abnormal_pupillary_reflex1.09241679
84MP0005379_endocrine/exocrine_gland_phen1.07710619
85MP0006072_abnormal_retinal_apoptosis1.06520567
86MP0002233_abnormal_nose_morphology1.06072028
87MP0003718_maternal_effect1.05978277
88MP0004742_abnormal_vestibular_system1.05500088
89MP0006035_abnormal_mitochondrial_morpho1.03582857
90MP0000613_abnormal_salivary_gland1.02397985
91MP0005391_vision/eye_phenotype1.01369174
92MP0004133_heterotaxia1.01274114
93MP0000358_abnormal_cell_content/1.00711309
94MP0003879_abnormal_hair_cell1.00504905
95MP0002066_abnormal_motor_capabilities/c1.00428600
96MP0005647_abnormal_sex_gland1.00401994
97MP0003755_abnormal_palate_morphology0.99952352
98MP0002909_abnormal_adrenal_gland0.99787998
99MP0003303_peritoneal_inflammation0.98105215
100MP0003329_amyloid_beta_deposits0.97418895
101MP0000955_abnormal_spinal_cord0.97113780
102MP0008875_abnormal_xenobiotic_pharmacok0.96808646
103MP0005499_abnormal_olfactory_system0.95244385
104MP0005394_taste/olfaction_phenotype0.95244385
105MP0008789_abnormal_olfactory_epithelium0.95096194
106MP0002876_abnormal_thyroid_physiology0.95009231
107MP0000569_abnormal_digit_pigmentation0.94387862
108MP0002009_preneoplasia0.94045484
109MP0003941_abnormal_skin_development0.93655501
110MP0005171_absent_coat_pigmentation0.93134761
111MP0003077_abnormal_cell_cycle0.93007363
112MP0002229_neurodegeneration0.91045398
113MP0005551_abnormal_eye_electrophysiolog0.90524824
114MP0003011_delayed_dark_adaptation0.89046970
115MP0004885_abnormal_endolymph0.88526615
116MP0002210_abnormal_sex_determination0.88326822
117MP0008058_abnormal_DNA_repair0.87580872
118MP0005195_abnormal_posterior_eye0.87555204
119MP0006036_abnormal_mitochondrial_physio0.86433445
120MP0001286_abnormal_eye_development0.86052760
121MP0005310_abnormal_salivary_gland0.85015275
122MP0001929_abnormal_gametogenesis0.84116792
123MP0005174_abnormal_tail_pigmentation0.83837258
124MP0001299_abnormal_eye_distance/0.83634340
125MP0004957_abnormal_blastocyst_morpholog0.80983836
126MP0003646_muscle_fatigue0.80146860
127MP0001485_abnormal_pinna_reflex0.79863003
128MP0002751_abnormal_autonomic_nervous0.79825519
129MP0002095_abnormal_skin_pigmentation0.78448551
130MP0004272_abnormal_basement_membrane0.78107790
131MP0002152_abnormal_brain_morphology0.76457654
132MP0001919_abnormal_reproductive_system0.75964740
133MP0000049_abnormal_middle_ear0.75769663
134MP0002084_abnormal_developmental_patter0.75001213
135MP0003111_abnormal_nucleus_morphology0.74757609
136MP0000920_abnormal_myelination0.73741323
137MP0005266_abnormal_metabolism0.73431587
138MP0003936_abnormal_reproductive_system0.73419981
139MP0005197_abnormal_uvea_morphology0.72708441
140MP0003698_abnormal_male_reproductive0.72439220
141MP0000631_abnormal_neuroendocrine_gland0.71719396
142MP0002163_abnormal_gland_morphology0.70972845
143MP0008057_abnormal_DNA_replication0.70805585
144MP0001963_abnormal_hearing_physiology0.69381906
145MP0002332_abnormal_exercise_endurance0.69156467
146MP0003567_abnormal_fetal_cardiomyocyte0.68315351
147MP0002090_abnormal_vision0.68193026
148MP0005187_abnormal_penis_morphology0.67344975
149MP0003385_abnormal_body_wall0.67313042
150MP0009780_abnormal_chondrocyte_physiolo0.66886176
151MP0000653_abnormal_sex_gland0.66727738
152MP0003634_abnormal_glial_cell0.66452592
153MP0002161_abnormal_fertility/fecundity0.66398201
154MP0002177_abnormal_outer_ear0.66159069
155MP0008995_early_reproductive_senescence0.65942268
156MP0002752_abnormal_somatic_nervous0.65799381
157MP0004858_abnormal_nervous_system0.61965024
158MP0005253_abnormal_eye_physiology0.61007804
159MP0002102_abnormal_ear_morphology0.60606958
160MP0000013_abnormal_adipose_tissue0.59438152
161MP0001145_abnormal_male_reproductive0.59078563
162MP0003724_increased_susceptibility_to0.57952160
163MP0002006_tumorigenesis0.57102798
164MP0003315_abnormal_perineum_morphology0.57054960
165MP0003183_abnormal_peptide_metabolism0.55725151
166MP0008872_abnormal_physiological_respon0.54496745

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.04919862
2Atonic seizures (HP:0010819)4.22024533
3Progressive cerebellar ataxia (HP:0002073)3.82224818
4Myokymia (HP:0002411)3.73511856
5Absence seizures (HP:0002121)3.47921413
6Gait imbalance (HP:0002141)3.37196206
7Genetic anticipation (HP:0003743)3.31707545
8Epileptic encephalopathy (HP:0200134)3.31168422
9Febrile seizures (HP:0002373)3.31047665
10Focal seizures (HP:0007359)3.25441789
11Acute necrotizing encephalopathy (HP:0006965)3.20003592
12Cerebral hypomyelination (HP:0006808)3.16153053
13Congenital primary aphakia (HP:0007707)3.12734874
14Abnormal hair whorl (HP:0010721)3.01157510
15Volvulus (HP:0002580)3.01079367
16Neuroendocrine neoplasm (HP:0100634)2.99784786
17Pheochromocytoma (HP:0002666)2.97334751
18Nephrogenic diabetes insipidus (HP:0009806)2.95963260
19Increased CSF lactate (HP:0002490)2.92375680
20Nephronophthisis (HP:0000090)2.86542795
21Abnormality of the ileum (HP:0001549)2.86420905
22Medial flaring of the eyebrow (HP:0010747)2.85955557
23Aplasia/Hypoplasia of the uvula (HP:0010293)2.82122399
24Visual hallucinations (HP:0002367)2.81492854
25Type II lissencephaly (HP:0007260)2.78667804
26Meckel diverticulum (HP:0002245)2.77390590
27Progressive macrocephaly (HP:0004481)2.76829007
28Dialeptic seizures (HP:0011146)2.74731380
29Mitochondrial inheritance (HP:0001427)2.74539515
30Truncal ataxia (HP:0002078)2.74201483
31Aplasia/Hypoplasia of the tibia (HP:0005772)2.71283173
32Abnormal mitochondria in muscle tissue (HP:0008316)2.67563699
33Generalized tonic-clonic seizures (HP:0002069)2.67364984
34Acute encephalopathy (HP:0006846)2.64500765
35Abnormality of the labia minora (HP:0012880)2.62449711
36Aplasia/Hypoplasia of the tongue (HP:0010295)2.62112903
37Short tibia (HP:0005736)2.60653277
38Pancreatic fibrosis (HP:0100732)2.60402487
39Urinary bladder sphincter dysfunction (HP:0002839)2.54272775
40CNS hypomyelination (HP:0003429)2.54202066
41Urinary urgency (HP:0000012)2.53919682
42Irregular epiphyses (HP:0010582)2.53013458
43Abnormality of chromosome stability (HP:0003220)2.52585940
44Chromosomal breakage induced by crosslinking agents (HP:0003221)2.48590615
45Specific learning disability (HP:0001328)2.46498083
46Poor coordination (HP:0002370)2.46169192
47Birth length less than 3rd percentile (HP:0003561)2.45330036
48Sclerocornea (HP:0000647)2.42182945
49Hepatocellular necrosis (HP:0001404)2.41745062
50Small hand (HP:0200055)2.41583359
51Abnormality of the renal medulla (HP:0100957)2.40466709
52Agitation (HP:0000713)2.39622060
53Increased hepatocellular lipid droplets (HP:0006565)2.34737079
54Scanning speech (HP:0002168)2.33211404
55Small intestinal stenosis (HP:0012848)2.32230093
56Duodenal stenosis (HP:0100867)2.32230093
57Type I transferrin isoform profile (HP:0003642)2.31302521
58Lipid accumulation in hepatocytes (HP:0006561)2.28119675
59Abnormality of alanine metabolism (HP:0010916)2.27186411
60Hyperalaninemia (HP:0003348)2.27186411
61Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.27186411
62Severe visual impairment (HP:0001141)2.26987729
63Abnormal protein glycosylation (HP:0012346)2.25241737
64Abnormal glycosylation (HP:0012345)2.25241737
65Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.25241737
66Abnormal protein N-linked glycosylation (HP:0012347)2.25241737
67Papilledema (HP:0001085)2.24751301
68Spastic gait (HP:0002064)2.24292866
69Papillary thyroid carcinoma (HP:0002895)2.22189787
70Intestinal atresia (HP:0011100)2.21031757
71Sloping forehead (HP:0000340)2.20988480
72Abnormality of the preputium (HP:0100587)2.18584177
73Impaired vibration sensation in the lower limbs (HP:0002166)2.16368177
74Genital tract atresia (HP:0001827)2.16164210
75Reduced antithrombin III activity (HP:0001976)2.14562010
76Methylmalonic acidemia (HP:0002912)2.14514955
77Congenital stationary night blindness (HP:0007642)2.13956443
78Median cleft lip (HP:0000161)2.13605038
79Ankle clonus (HP:0011448)2.12137266
80Mutism (HP:0002300)2.10776587
81Abnormality of the renal cortex (HP:0011035)2.10661910
82Peripheral hypomyelination (HP:0007182)2.09277501
83Adrenal hypoplasia (HP:0000835)2.08699550
84Gaze-evoked nystagmus (HP:0000640)2.08572492
85Capillary hemangiomas (HP:0005306)2.08465580
86Abnormality of the duodenum (HP:0002246)2.07665770
87Unsteady gait (HP:0002317)2.07523847
88Vaginal atresia (HP:0000148)2.07336884
89Absent speech (HP:0001344)2.07028268
90Optic nerve hypoplasia (HP:0000609)2.06949096
91Prostate neoplasm (HP:0100787)2.06230958
92Cerebellar dysplasia (HP:0007033)2.06150322
93Postaxial foot polydactyly (HP:0001830)2.05698335
94True hermaphroditism (HP:0010459)2.05421693
95Congenital, generalized hypertrichosis (HP:0004540)2.04907415
96Supernumerary spleens (HP:0009799)2.02932288
97Increased serum lactate (HP:0002151)2.02567800
98Hepatic necrosis (HP:0002605)2.02227361
99Amyotrophic lateral sclerosis (HP:0007354)2.01585277
100Anencephaly (HP:0002323)2.00896607
101Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.99455249
102Impaired smooth pursuit (HP:0007772)1.99088679
103Degeneration of the lateral corticospinal tracts (HP:0002314)1.98922168
104Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.98922168
105Preaxial hand polydactyly (HP:0001177)1.98008550
106Inappropriate behavior (HP:0000719)1.96908524
107Abnormality of the corticospinal tract (HP:0002492)1.96547843
108Progressive inability to walk (HP:0002505)1.95643663
109Gastrointestinal atresia (HP:0002589)1.95127573
110Furrowed tongue (HP:0000221)1.94983828
111Cystic liver disease (HP:0006706)1.94375664
112Aqueductal stenosis (HP:0002410)1.92816662
113Abnormal lung lobation (HP:0002101)1.92775523
1143-Methylglutaconic aciduria (HP:0003535)1.90733396
115Occipital encephalocele (HP:0002085)1.90328153
116Dandy-Walker malformation (HP:0001305)1.88513017
117Abnormal ciliary motility (HP:0012262)1.87509878
118Abnormal respiratory motile cilium physiology (HP:0012261)1.86946042
119Type 2 muscle fiber atrophy (HP:0003554)1.85806659
120Pancreatic cysts (HP:0001737)1.85739237
121Male pseudohermaphroditism (HP:0000037)1.85568654
122Abnormal eating behavior (HP:0100738)1.85474804
123Delayed gross motor development (HP:0002194)1.85391397
124Oligodactyly (hands) (HP:0001180)1.84813134
125Hypoplasia of the fovea (HP:0007750)1.83983400
126Aplasia/Hypoplasia of the fovea (HP:0008060)1.83983400
127Septo-optic dysplasia (HP:0100842)1.82902084
128Amniotic constriction ring (HP:0009775)1.82746825
129Abnormality of placental membranes (HP:0011409)1.82746825
130Slow saccadic eye movements (HP:0000514)1.82592260
131Postaxial hand polydactyly (HP:0001162)1.81129819
132Abnormality of the pons (HP:0007361)1.80793095
133Renal Fanconi syndrome (HP:0001994)1.80412188
134Methylmalonic aciduria (HP:0012120)1.80311166
135Colon cancer (HP:0003003)1.79981488
136Emotional lability (HP:0000712)1.79862545
137Abnormality of binocular vision (HP:0011514)1.79057142
138Diplopia (HP:0000651)1.79057142
139Horseshoe kidney (HP:0000085)1.78104209
140Ectopic kidney (HP:0000086)1.76863337
141Fibular aplasia (HP:0002990)1.76444925
142Polyphagia (HP:0002591)1.75988620
143Cerebral edema (HP:0002181)1.75959339
144Neoplasm of the peripheral nervous system (HP:0100007)1.75227859
145Chronic hepatic failure (HP:0100626)1.74936335
146Epileptiform EEG discharges (HP:0011182)1.74825966
147Dysmetria (HP:0001310)1.74559592
148Supranuclear gaze palsy (HP:0000605)1.74507602
149Termporal pattern (HP:0011008)1.73794650
150Insidious onset (HP:0003587)1.73794650
151Pendular nystagmus (HP:0012043)1.73598012
152Aganglionic megacolon (HP:0002251)1.72831672
153Action tremor (HP:0002345)1.72813994
154Hypoplasia of the pons (HP:0012110)1.72723719
155Absent septum pellucidum (HP:0001331)1.72372181
156Limb dystonia (HP:0002451)1.72228270
157Tubular atrophy (HP:0000092)1.72047083
158Broad-based gait (HP:0002136)1.70528524
159Depression (HP:0000716)1.70447186
160EEG with generalized epileptiform discharges (HP:0011198)1.70040724
161Aplasia/Hypoplasia of the lens (HP:0008063)1.69051707
162Narrow nasal bridge (HP:0000446)1.69012467
163Hypothermia (HP:0002045)1.66874827
164Abnormality of midbrain morphology (HP:0002418)1.64161462
165Molar tooth sign on MRI (HP:0002419)1.64161462
166Blue irides (HP:0000635)1.63964853
167Hypercortisolism (HP:0001578)1.63704408
168Small epiphyses (HP:0010585)1.63496593
169Widely spaced teeth (HP:0000687)1.63025499
170Astigmatism (HP:0000483)1.62685459
171Fetal akinesia sequence (HP:0001989)1.62573944
172Chromsome breakage (HP:0040012)1.60055010
173Broad foot (HP:0001769)1.58674648
174Abnormality of macular pigmentation (HP:0008002)1.58103705
175Poor eye contact (HP:0000817)1.57936899
176Menstrual irregularities (HP:0000858)1.57744719
177Abnormality of ocular smooth pursuit (HP:0000617)1.55312848
178Excessive salivation (HP:0003781)1.55094295
179Drooling (HP:0002307)1.55094295
180Decreased testicular size (HP:0008734)1.55070444
181Abnormality of the fovea (HP:0000493)1.54969397
182Apathy (HP:0000741)1.54711604
183Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.54161896
184Absent epiphyses (HP:0010577)1.54161896
185Gait ataxia (HP:0002066)1.53674987
186Postnatal microcephaly (HP:0005484)1.53605643

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.83949442
2CASK3.35904926
3ACVR1B3.22088572
4FRK2.92495609
5BUB12.89273891
6MAP3K42.70693428
7MAP3K122.63696411
8TSSK62.46590953
9MAP2K72.43024068
10PBK2.22251139
11NUAK12.16505751
12TRIM282.14394523
13MINK12.06927095
14CDK192.01024862
15ZAK1.97099712
16TAOK11.94734560
17MARK11.91559232
18PLK21.88998183
19WNK31.86810299
20VRK21.82116177
21LIMK11.81936421
22PNCK1.77105573
23MAP3K91.74251999
24LATS21.60907351
25TNK21.60144239
26TNIK1.59733106
27EIF2AK31.57008272
28CDC71.56883445
29EIF2AK11.54846975
30ADRBK21.53344292
31NTRK21.46934808
32MUSK1.44301414
33TTK1.41701956
34MAP4K21.38851133
35GRK11.37648234
36CSNK1G21.35621434
37MAPK131.34978527
38NEK21.32722353
39PASK1.31762282
40CSNK1G31.30596248
41STK31.26618430
42TXK1.25123003
43MKNK21.24827803
44SIK31.21461120
45LATS11.20051285
46BMPR1B1.19769186
47TLK11.19278246
48WNK41.18571688
49BCR1.18161085
50MST41.17946016
51ALK1.17588384
52CAMKK21.17209778
53BMPR21.15933687
54PAK61.15001035
55STK391.12416560
56CCNB11.11244756
57SGK21.07288439
58SCYL21.04733706
59TAF11.04460574
60STK381.03709812
61SGK2231.01942584
62SGK4941.01942584
63MAP2K41.00898689
64CSNK1A1L0.97460046
65CDK50.95865756
66CDK140.95562294
67STK38L0.95523886
68MST1R0.94045129
69PRKD30.92922219
70ERBB40.92152074
71CSNK1G10.91822440
72PLK30.91661909
73DAPK10.89382092
74HIPK20.84993835
75NEK10.84918742
76EIF2AK20.84581205
77UHMK10.84298926
78FES0.80706771
79AURKB0.79782119
80CDK180.79329951
81MARK30.78180342
82TGFBR10.75478505
83GRK50.75199671
84NME10.73829276
85CDK150.72290101
86MET0.71728853
87PRKCG0.70879888
88BRAF0.70763511
89MAP4K10.69825127
90CDK11A0.69551537
91VRK10.68655719
92CAMKK10.68296222
93ATR0.67805104
94AURKA0.67409226
95INSRR0.67299626
96CAMK2A0.66670160
97DYRK1A0.66511254
98PDK20.66390545
99NEK60.66064869
100PRKCE0.65618243
101OXSR10.64682901
102DAPK20.64560057
103FLT30.64235842
104ATM0.62420908
105EPHA40.62038864
106PRPF4B0.60017170
107CHEK20.59815321
108NTRK10.59299308
109WNK10.59264984
110SRPK10.58891213
111EPHA20.57048298
112NEK90.56450677
113TIE10.55764189
114MAPK100.55572460
115PRKCH0.55310693
116ADRBK10.55266626
117SGK30.52460998
118STK100.51835906
119TAOK30.50783436
120EPHB20.50705349
121MKNK10.49554287
122GRK70.49535607
123BRSK10.48890568
124CAMK10.48881592
125PAK30.48851995
126MYLK0.48571019
127TESK20.48031237
128NLK0.46095672
129STK40.45841447
130KSR10.45056147
131RPS6KA40.44928792
132CSNK2A10.44748972
133BRSK20.44710850
134ERBB30.44546550
135PTK2B0.44173720
136MAPKAPK30.44126857
137PKN10.43626322
138PLK10.43141351
139PRKCI0.43088532
140DYRK30.41391523
141STK160.41300778
142CDK80.41118939
143PLK40.41097291
144FGFR10.40452472
145NME20.40281820
146PINK10.40053656
147RAF10.39629756
148SGK10.39552359
149CHEK10.38439406
150MAP3K60.37959156
151CSNK2A20.37425536
152ARAF0.37383261
153BCKDK0.36955955
154WEE10.35913252
155ABL20.35277006
156LMTK20.35149614

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.31023415
2Nicotine addiction_Homo sapiens_hsa050333.03058375
3Oxidative phosphorylation_Homo sapiens_hsa001902.61391888
4Parkinsons disease_Homo sapiens_hsa050122.24736806
5GABAergic synapse_Homo sapiens_hsa047272.13524709
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.04616550
7Morphine addiction_Homo sapiens_hsa050321.99541068
8Pyrimidine metabolism_Homo sapiens_hsa002401.94039959
9Selenocompound metabolism_Homo sapiens_hsa004501.90040319
10Collecting duct acid secretion_Homo sapiens_hsa049661.81552058
11Huntingtons disease_Homo sapiens_hsa050161.81018641
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.80360176
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.79586839
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.78194088
15Vibrio cholerae infection_Homo sapiens_hsa051101.74403584
16Circadian entrainment_Homo sapiens_hsa047131.69363271
17One carbon pool by folate_Homo sapiens_hsa006701.67482104
18Ribosome_Homo sapiens_hsa030101.65846127
19Propanoate metabolism_Homo sapiens_hsa006401.62395673
20Olfactory transduction_Homo sapiens_hsa047401.61631167
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.59060032
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.57310342
23Glutamatergic synapse_Homo sapiens_hsa047241.56959022
24Oocyte meiosis_Homo sapiens_hsa041141.56733101
25Dopaminergic synapse_Homo sapiens_hsa047281.52891196
26Long-term potentiation_Homo sapiens_hsa047201.50400282
27Purine metabolism_Homo sapiens_hsa002301.49792439
28Serotonergic synapse_Homo sapiens_hsa047261.47523925
29Amphetamine addiction_Homo sapiens_hsa050311.45992347
30Basal transcription factors_Homo sapiens_hsa030221.42112698
31Alzheimers disease_Homo sapiens_hsa050101.41535214
32Insulin secretion_Homo sapiens_hsa049111.40866073
33Base excision repair_Homo sapiens_hsa034101.39783750
34Taste transduction_Homo sapiens_hsa047421.39761098
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.36415678
36Type I diabetes mellitus_Homo sapiens_hsa049401.31716789
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.30661813
38Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.27439406
39Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.25263925
40Cholinergic synapse_Homo sapiens_hsa047251.24336383
41Cell cycle_Homo sapiens_hsa041101.23621411
42Long-term depression_Homo sapiens_hsa047301.22745745
43Folate biosynthesis_Homo sapiens_hsa007901.21522107
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.19840309
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.18167367
46Butanoate metabolism_Homo sapiens_hsa006501.18056337
47Salivary secretion_Homo sapiens_hsa049701.17474174
48Steroid biosynthesis_Homo sapiens_hsa001001.14960868
49Proteasome_Homo sapiens_hsa030501.09705788
50RNA transport_Homo sapiens_hsa030131.08586710
51Circadian rhythm_Homo sapiens_hsa047101.07486418
52Rheumatoid arthritis_Homo sapiens_hsa053231.07269439
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.07027162
54p53 signaling pathway_Homo sapiens_hsa041151.06079778
55Sulfur metabolism_Homo sapiens_hsa009201.05692517
56Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.05136849
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.04208729
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.01818063
59Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.00602215
60Cocaine addiction_Homo sapiens_hsa050300.99948861
61GnRH signaling pathway_Homo sapiens_hsa049120.96065488
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94413220
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.93380173
64Nitrogen metabolism_Homo sapiens_hsa009100.91987107
65Glutathione metabolism_Homo sapiens_hsa004800.90887662
66Gastric acid secretion_Homo sapiens_hsa049710.90533750
67Oxytocin signaling pathway_Homo sapiens_hsa049210.90485828
68Pyruvate metabolism_Homo sapiens_hsa006200.90197110
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88805135
70Vitamin B6 metabolism_Homo sapiens_hsa007500.88409937
71RNA degradation_Homo sapiens_hsa030180.88227043
72Estrogen signaling pathway_Homo sapiens_hsa049150.86922443
73Peroxisome_Homo sapiens_hsa041460.86695388
74Fanconi anemia pathway_Homo sapiens_hsa034600.86633113
75Aldosterone synthesis and secretion_Homo sapiens_hsa049250.86397467
76TGF-beta signaling pathway_Homo sapiens_hsa043500.86088486
77Spliceosome_Homo sapiens_hsa030400.85899261
78ErbB signaling pathway_Homo sapiens_hsa040120.84854002
79Gap junction_Homo sapiens_hsa045400.84456856
80Phagosome_Homo sapiens_hsa041450.84127668
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83553662
82Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.83341249
83Primary bile acid biosynthesis_Homo sapiens_hsa001200.83103830
84Epstein-Barr virus infection_Homo sapiens_hsa051690.81759258
85mRNA surveillance pathway_Homo sapiens_hsa030150.80807055
86T cell receptor signaling pathway_Homo sapiens_hsa046600.79425860
87Regulation of autophagy_Homo sapiens_hsa041400.78834345
88MAPK signaling pathway_Homo sapiens_hsa040100.78548471
89Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.78524235
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78392799
91Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.77028271
92Nucleotide excision repair_Homo sapiens_hsa034200.76738105
93Type II diabetes mellitus_Homo sapiens_hsa049300.74392840
94Renal cell carcinoma_Homo sapiens_hsa052110.74274568
95Metabolic pathways_Homo sapiens_hsa011000.73593585
96Colorectal cancer_Homo sapiens_hsa052100.73487036
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73474618
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73189551
99Primary immunodeficiency_Homo sapiens_hsa053400.73183733
100Cardiac muscle contraction_Homo sapiens_hsa042600.73056610
101Renin secretion_Homo sapiens_hsa049240.72625718
102Fatty acid elongation_Homo sapiens_hsa000620.71776485
103Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.70403674
104Homologous recombination_Homo sapiens_hsa034400.70250530
105Calcium signaling pathway_Homo sapiens_hsa040200.68806640
106Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68122308
107Hippo signaling pathway_Homo sapiens_hsa043900.67028001
108Prolactin signaling pathway_Homo sapiens_hsa049170.66240265
109Hedgehog signaling pathway_Homo sapiens_hsa043400.65836652
110Antigen processing and presentation_Homo sapiens_hsa046120.64863585
111NOD-like receptor signaling pathway_Homo sapiens_hsa046210.64581981
112Neurotrophin signaling pathway_Homo sapiens_hsa047220.63496970
113Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.63039289
114Protein export_Homo sapiens_hsa030600.61562994
115RNA polymerase_Homo sapiens_hsa030200.60640236
116Glioma_Homo sapiens_hsa052140.60433479
117Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59745113
118Dorso-ventral axis formation_Homo sapiens_hsa043200.59626752
119cAMP signaling pathway_Homo sapiens_hsa040240.59429392
120Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59150130
121Phototransduction_Homo sapiens_hsa047440.58345449
122Endocytosis_Homo sapiens_hsa041440.58118981
123Alcoholism_Homo sapiens_hsa050340.57665348
124Steroid hormone biosynthesis_Homo sapiens_hsa001400.57582486
125Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.57542297
126N-Glycan biosynthesis_Homo sapiens_hsa005100.56019893
127Measles_Homo sapiens_hsa051620.55630782
128Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.55280190
129Mismatch repair_Homo sapiens_hsa034300.55100873
130Hematopoietic cell lineage_Homo sapiens_hsa046400.54708374
131Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53075441
132Chemokine signaling pathway_Homo sapiens_hsa040620.52825339
133Shigellosis_Homo sapiens_hsa051310.52024501
134Choline metabolism in cancer_Homo sapiens_hsa052310.51091116
135Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50357779
136DNA replication_Homo sapiens_hsa030300.50209630
137Non-homologous end-joining_Homo sapiens_hsa034500.49637981
138Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49598273
139Asthma_Homo sapiens_hsa053100.48960129
140Tryptophan metabolism_Homo sapiens_hsa003800.48523477
141Ras signaling pathway_Homo sapiens_hsa040140.47970084
142Graft-versus-host disease_Homo sapiens_hsa053320.47962371
143Axon guidance_Homo sapiens_hsa043600.46987104
144Vascular smooth muscle contraction_Homo sapiens_hsa042700.46846735
145Caffeine metabolism_Homo sapiens_hsa002320.46564252
146Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46531352
147Chemical carcinogenesis_Homo sapiens_hsa052040.46363705
148Phospholipase D signaling pathway_Homo sapiens_hsa040720.44245979
149Ovarian steroidogenesis_Homo sapiens_hsa049130.44116965
150Pancreatic cancer_Homo sapiens_hsa052120.44019640
151Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43948495
152Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.43858918
153Maturity onset diabetes of the young_Homo sapiens_hsa049500.43703771
154Salmonella infection_Homo sapiens_hsa051320.43523353
155Ether lipid metabolism_Homo sapiens_hsa005650.42616274
156Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42349893
157Basal cell carcinoma_Homo sapiens_hsa052170.41757605
158Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39305315
159Sulfur relay system_Homo sapiens_hsa041220.39285091
160Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38234495
161Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37669854
162Retinol metabolism_Homo sapiens_hsa008300.37039269
163Legionellosis_Homo sapiens_hsa051340.35032478
164Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.34919072
165Mineral absorption_Homo sapiens_hsa049780.34396971
166Sphingolipid metabolism_Homo sapiens_hsa006000.33660929
167beta-Alanine metabolism_Homo sapiens_hsa004100.32308640
168Linoleic acid metabolism_Homo sapiens_hsa005910.28691979
169Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27469752
170Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.27279839
171Drug metabolism - other enzymes_Homo sapiens_hsa009830.21422467
172Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.20627695
173Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.19544696

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