SNAPC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of the snRNA-activating protein complex which is associated with the TATA box-binding protein. The encoded protein is necessary for RNA polymerase II and III dependent small-nuclear RNA gene transcription. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)7.02068980
2negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)5.34094867
3ribosomal small subunit assembly (GO:0000028)5.27115156
4purine nucleobase biosynthetic process (GO:0009113)5.03877995
5protein maturation by protein folding (GO:0022417)4.96623546
6nucleobase biosynthetic process (GO:0046112)4.96522710
7Golgi transport vesicle coating (GO:0048200)4.85369716
8COPI coating of Golgi vesicle (GO:0048205)4.85369716
9maturation of SSU-rRNA (GO:0030490)4.85164100
10formation of translation preinitiation complex (GO:0001731)4.77294819
11ribosome biogenesis (GO:0042254)4.54027317
12DNA strand elongation involved in DNA replication (GO:0006271)4.38939481
13negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.33286190
14deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.25115561
15DNA strand elongation (GO:0022616)4.16024706
16DNA replication initiation (GO:0006270)4.13426681
17protein retention in ER lumen (GO:0006621)4.11970977
18viral transcription (GO:0019083)4.07825488
19translational termination (GO:0006415)4.04805634
20ribonucleoprotein complex biogenesis (GO:0022613)4.04520979
21telomere maintenance via semi-conservative replication (GO:0032201)3.97279594
22regulation of mammary gland epithelial cell proliferation (GO:0033599)3.93974332
23spliceosomal snRNP assembly (GO:0000387)3.93927115
24maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.90963010
25GDP-mannose metabolic process (GO:0019673)3.89634938
26translational elongation (GO:0006414)3.83793433
27negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.82799843
28barbed-end actin filament capping (GO:0051016)3.82701144
29pseudouridine synthesis (GO:0001522)3.77118833
30translational initiation (GO:0006413)3.76198416
31ribosomal small subunit biogenesis (GO:0042274)3.75551311
32regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.72180046
33protein localization to endosome (GO:0036010)3.69145658
34positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.67953041
35anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.66517706
36DNA replication checkpoint (GO:0000076)3.63364035
37peptidyl-arginine omega-N-methylation (GO:0035247)3.58264708
38pyrimidine nucleoside salvage (GO:0043097)3.57339906
39pyrimidine-containing compound salvage (GO:0008655)3.57339906
40rRNA processing (GO:0006364)3.54944693
41mitotic metaphase plate congression (GO:0007080)3.53993491
42nuclear envelope reassembly (GO:0031468)3.52809180
43mitotic nuclear envelope reassembly (GO:0007084)3.52809180
44protein insertion into membrane (GO:0051205)3.52402035
45L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.50493661
46negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.50474181
47negative regulation of ligase activity (GO:0051352)3.50474181
48NIK/NF-kappaB signaling (GO:0038061)3.50334813
49virion assembly (GO:0019068)3.50069517
50ribosome assembly (GO:0042255)3.47983215
51proline biosynthetic process (GO:0006561)3.47808378
52regulation of retinoic acid receptor signaling pathway (GO:0048385)3.47097776
53transcription elongation from RNA polymerase III promoter (GO:0006385)3.45839832
54termination of RNA polymerase III transcription (GO:0006386)3.45839832
55SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.44933067
56rRNA metabolic process (GO:0016072)3.44555883
57negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.44071763
58telomere maintenance via recombination (GO:0000722)3.43805973
59proteasome assembly (GO:0043248)3.41505459
60pentose metabolic process (GO:0019321)3.40848258
61nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.39034203
62DNA unwinding involved in DNA replication (GO:0006268)3.38308711
63IMP biosynthetic process (GO:0006188)3.35717861
64cellular component biogenesis (GO:0044085)3.34717284
65negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.34293195
66cotranslational protein targeting to membrane (GO:0006613)3.30891412
67pentose-phosphate shunt (GO:0006098)3.30747821
68protein targeting to ER (GO:0045047)3.29469348
69protein localization to kinetochore (GO:0034501)3.29123509
70retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.28763757
71histone arginine methylation (GO:0034969)3.27525355
72rRNA modification (GO:0000154)3.26056921
73positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.25734061
74ribosomal large subunit biogenesis (GO:0042273)3.24202465
75pinocytosis (GO:0006907)3.23985509
76viral life cycle (GO:0019058)3.23340909
77viral protein processing (GO:0019082)3.21046671
78regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.19825592
79cellular protein complex disassembly (GO:0043624)3.19723180
80negative regulation of RNA splicing (GO:0033119)3.16261301
81purine-containing compound salvage (GO:0043101)3.14245776
82translation (GO:0006412)3.13826610
83regulation of early endosome to late endosome transport (GO:2000641)3.13669182
84positive regulation of ligase activity (GO:0051351)3.12802591
85peptidyl-arginine N-methylation (GO:0035246)3.12675319
86peptidyl-arginine methylation (GO:0018216)3.12675319
87protein localization to endoplasmic reticulum (GO:0070972)3.12199934
88DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.11051077
89telomere maintenance via telomere lengthening (GO:0010833)3.09067380
90tRNA methylation (GO:0030488)3.08635935
91establishment of protein localization to endoplasmic reticulum (GO:0072599)3.08313811
92mitochondrial fusion (GO:0008053)3.07562819
93positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.06287530
94folic acid metabolic process (GO:0046655)3.05857940
95intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.05264750
96signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.05264750
97mitotic recombination (GO:0006312)3.04696044
98signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.02870243
99signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.02870243
100signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.02870243
101maturation of 5.8S rRNA (GO:0000460)3.00303790
102signal transduction involved in DNA damage checkpoint (GO:0072422)2.99635456
103signal transduction involved in DNA integrity checkpoint (GO:0072401)2.99635456
104cell cycle G1/S phase transition (GO:0044843)2.99266540
105G1/S transition of mitotic cell cycle (GO:0000082)2.99266540
106protein complex disassembly (GO:0043241)2.99086706
107exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.98462148
108regulation of cellular amino acid metabolic process (GO:0006521)2.97663579
109amyloid precursor protein catabolic process (GO:0042987)2.97319599
110regulation of ubiquitin-protein transferase activity (GO:0051438)2.96541407
111negative regulation of cell size (GO:0045792)2.94728481
112spliceosomal complex assembly (GO:0000245)2.93989499
113signal transduction involved in cell cycle checkpoint (GO:0072395)2.93534158
114regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.92291668
115UV protection (GO:0009650)2.90872884
116polyamine biosynthetic process (GO:0006596)2.90560163
117protein deneddylation (GO:0000338)2.89540143
118glucose catabolic process (GO:0006007)2.88883146
119transcription-coupled nucleotide-excision repair (GO:0006283)2.88708950
120establishment of integrated proviral latency (GO:0075713)2.88528305
121pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.88119146
122regulation of ligase activity (GO:0051340)2.86938869
123nucleotide-excision repair, DNA gap filling (GO:0006297)2.86646805
124modulation by virus of host process (GO:0019054)2.85830820
125macromolecular complex disassembly (GO:0032984)2.85545843
126metaphase plate congression (GO:0051310)2.85504949
127IMP metabolic process (GO:0046040)2.85367243
128nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.84941024
129intra-S DNA damage checkpoint (GO:0031573)2.84302241
130endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.83546224
131negative regulation of DNA-templated transcription, elongation (GO:0032785)2.83495350
132negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.83495350
133positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.83287969
134antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.83050293
135viral mRNA export from host cell nucleus (GO:0046784)2.82635243
136mitotic nuclear envelope disassembly (GO:0007077)2.82495294
137protein localization to chromosome, centromeric region (GO:0071459)2.82362050
138L-methionine biosynthetic process (GO:0071265)2.82083645
139negative regulation of erythrocyte differentiation (GO:0045647)2.81631472
140stress fiber assembly (GO:0043149)2.77345285
141mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.75079202
142modulation by symbiont of host cellular process (GO:0044068)2.75047305
143hyaluronan catabolic process (GO:0030214)2.73076884
144apoptotic process involved in morphogenesis (GO:0060561)2.73014892
145chaperone mediated protein folding requiring cofactor (GO:0051085)2.72006092
146lipopolysaccharide biosynthetic process (GO:0009103)2.71569525
147regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.70646421
148regulation of release of cytochrome c from mitochondria (GO:0090199)2.69692888
149NADPH regeneration (GO:0006740)2.69056441
150lipopolysaccharide metabolic process (GO:0008653)2.62498678
151regulation of defense response to virus by virus (GO:0050690)2.60240605
152establishment of viral latency (GO:0019043)2.58964188
153purine deoxyribonucleotide catabolic process (GO:0009155)2.57976369
154amino sugar catabolic process (GO:0046348)2.57178837
155regulation of superoxide anion generation (GO:0032928)2.56727154
156guanosine-containing compound biosynthetic process (GO:1901070)2.54573492
157nucleobase-containing small molecule interconversion (GO:0015949)2.50825451
158mitotic chromosome condensation (GO:0007076)2.50703711
159positive regulation of release of cytochrome c from mitochondria (GO:0090200)2.50498215
160positive regulation of protein sumoylation (GO:0033235)2.47593735
161nucleoside salvage (GO:0043174)2.46865256
162nucleotide salvage (GO:0043173)2.44595613
163cellular response to arsenic-containing substance (GO:0071243)2.42812257
164positive regulation of protein homooligomerization (GO:0032464)2.41876641
165adhesion of symbiont to host (GO:0044406)2.41722721
166negative regulation of ERBB signaling pathway (GO:1901185)2.41292033
167negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.40867736
168metallo-sulfur cluster assembly (GO:0031163)2.39052922
169iron-sulfur cluster assembly (GO:0016226)2.39052922
170glucose 6-phosphate metabolic process (GO:0051156)2.37059280
171negative regulation of epidermal growth factor receptor signaling pathway (GO:0042059)2.35801033
172intracellular estrogen receptor signaling pathway (GO:0030520)2.34449380
1732-deoxyribonucleotide biosynthetic process (GO:0009265)2.34410293
174deoxyribose phosphate biosynthetic process (GO:0046385)2.34410293
175endothelial tube morphogenesis (GO:0061154)2.33851876
176morphogenesis of an endothelium (GO:0003159)2.33851876
177virion attachment to host cell (GO:0019062)2.31937263
178adhesion of symbiont to host cell (GO:0044650)2.31937263
179skin morphogenesis (GO:0043589)2.31374418
180regulation of translational termination (GO:0006449)2.31234264
181embryo implantation (GO:0007566)2.28695823
182modulation by virus of host morphology or physiology (GO:0019048)2.28340255
183basement membrane organization (GO:0071711)2.28138369
184pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.27722496
185protein targeting to mitochondrion (GO:0006626)2.27003994
186ncRNA 3-end processing (GO:0043628)2.25853542
187pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.24531234
188negative regulation of mitochondrion organization (GO:0010823)2.23411680

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.45725250
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.31118287
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.25937839
4* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.24813161
5ETS1_20019798_ChIP-Seq_JURKAT_Human3.13203260
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.07236857
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.06194136
8* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.04409448
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.90712939
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.85545741
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.83762109
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.73693796
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.71783546
14XRN2_22483619_ChIP-Seq_HELA_Human2.59388064
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.58682301
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.35171645
17LXR_22292898_ChIP-Seq_THP-1_Human2.33542144
18RARG_19884340_ChIP-ChIP_MEFs_Mouse2.32373565
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.30504018
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.30474473
21GABP_19822575_ChIP-Seq_HepG2_Human2.21680200
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.21208687
23* VDR_23849224_ChIP-Seq_CD4+_Human2.19925796
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.19026306
25THAP11_20581084_ChIP-Seq_MESCs_Mouse2.15175889
26E2F1_18555785_ChIP-Seq_MESCs_Mouse2.14654490
27FOXM1_23109430_ChIP-Seq_U2OS_Human2.03888281
28DCP1A_22483619_ChIP-Seq_HELA_Human2.03168903
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.01793295
30MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.99430538
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.98916885
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.96996219
33TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.94899796
34MYC_22102868_ChIP-Seq_BL_Human1.94542350
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.90263262
36THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.90188066
37* ZNF263_19887448_ChIP-Seq_K562_Human1.89510218
38FOXP3_21729870_ChIP-Seq_TREG_Human1.86146922
39* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.83744747
40CIITA_25753668_ChIP-Seq_RAJI_Human1.83690856
41TTF2_22483619_ChIP-Seq_HELA_Human1.81817118
42E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.81452183
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.75614471
44SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.75329840
45RACK7_27058665_Chip-Seq_MCF-7_Human1.73525306
46MYCN_18555785_ChIP-Seq_MESCs_Mouse1.72746511
47CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.70747889
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.67313353
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64035666
50NANOG_18555785_ChIP-Seq_MESCs_Mouse1.63324620
51KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.62660212
52* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.62009343
53* SRF_21415370_ChIP-Seq_HL-1_Mouse1.60874253
54PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.60457159
55POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.57768718
56P68_20966046_ChIP-Seq_HELA_Human1.56489871
57EGR1_19374776_ChIP-ChIP_THP-1_Human1.56156229
58AR_21909140_ChIP-Seq_LNCAP_Human1.55979008
59KDM2B_26808549_Chip-Seq_SUP-B15_Human1.54767744
60SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.54367379
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.50424933
62HOXB4_20404135_ChIP-ChIP_EML_Mouse1.47887492
63VDR_21846776_ChIP-Seq_THP-1_Human1.46973762
64* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.46867343
65ELF1_20517297_ChIP-Seq_JURKAT_Human1.42907497
66TP63_17297297_ChIP-ChIP_HaCaT_Human1.42880131
67ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.42795856
68CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.40146955
69UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.39594979
70KDM5A_27292631_Chip-Seq_BREAST_Human1.38052327
71E2F1_21310950_ChIP-Seq_MCF-7_Human1.37783996
72KDM2B_26808549_Chip-Seq_DND41_Human1.37178395
73* SA1_27219007_Chip-Seq_ERYTHROID_Human1.34985695
74ERG_20887958_ChIP-Seq_HPC-7_Mouse1.34728706
75ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.33600991
76YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33401077
77* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.32827324
78* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.32055720
79KLF4_18555785_ChIP-Seq_MESCs_Mouse1.30118145
80BCL6_27268052_Chip-Seq_Bcells_Human1.29784514
81CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.29004932
82CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.28897805
83SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.28473857
84POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.27936399
85BCOR_27268052_Chip-Seq_Bcells_Human1.27213392
86MAF_26560356_Chip-Seq_TH2_Human1.26361336
87PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.25448753
88VDR_24763502_ChIP-Seq_THP-1_Human1.23550182
89STAT3_1855785_ChIP-Seq_MESCs_Mouse1.21845120
90* ATF3_27146783_Chip-Seq_COLON_Human1.21330293
91NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.20199284
92CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.19842757
93TCF7_22412390_ChIP-Seq_EML_Mouse1.19710562
94HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.18438066
95NCOR1_26117541_ChIP-Seq_K562_Human1.17518021
96MAF_26560356_Chip-Seq_TH1_Human1.16989407
97PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16800538
98SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.16439959
99TFEB_21752829_ChIP-Seq_HELA_Human1.15856327
100* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.15146074
101CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.15044074
102RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.14604735
103ELK1_19687146_ChIP-ChIP_HELA_Human1.14483382
104SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.13472325
105ELK1_22589737_ChIP-Seq_MCF10A_Human1.13233061
106ZFP281_18757296_ChIP-ChIP_E14_Mouse1.12868410
107CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.12852738
108BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.12510688
109NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.12442422
110UTX_26944678_Chip-Seq_JUKART_Human1.12349621
111* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11159788
112TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10789929
113E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10459168
114TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10057984
115CTCF_26484167_Chip-Seq_Bcells_Mouse1.09481149
116TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09337430
117* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.08662853
118TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07929381
119* CTCF_21964334_Chip-Seq_Bcells_Human1.06989571
120KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.06966834
121TP53_22127205_ChIP-Seq_IMR90_Human1.06656008
122SMC4_20622854_ChIP-Seq_HELA_Human1.06550605
123KDM2B_26808549_Chip-Seq_K562_Human1.06319673
124PU.1_20513432_ChIP-Seq_Bcells_Mouse1.05611876
125SPI1_23547873_ChIP-Seq_NB4_Human1.04439612
126SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.04179037
127RUNX1_22412390_ChIP-Seq_EML_Mouse1.04039787
128MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.03754115
129GATA1_22383799_ChIP-Seq_G1ME_Mouse1.03550667
130SRY_22984422_ChIP-ChIP_TESTIS_Rat1.03549704
131GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.03081404
132RARA_24833708_ChIP-Seq_LIVER_Mouse1.02754171
133* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02734627
134RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.02372341
135POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01585692
136TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.00625941
137SOX2_18555785_ChIP-Seq_MESCs_Mouse1.00546973
138CTCF_18555785_ChIP-Seq_MESCs_Mouse0.96836369
139YY1_22570637_ChIP-Seq_MALME-3M_Human0.95176431
140* FOXP1_21924763_ChIP-Seq_HESCs_Human0.93353979
141RBPJ_22232070_ChIP-Seq_NCS_Mouse0.92711565
142* TP63_19390658_ChIP-ChIP_HaCaT_Human0.92101616
143EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.90587711
144ELK3_25401928_ChIP-Seq_HUVEC_Human0.90562980
145OCT4_18692474_ChIP-Seq_MEFs_Mouse0.89693483
146* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89646857
147* TET1_21451524_ChIP-Seq_MESCs_Mouse0.88319317
148NANOG_21062744_ChIP-ChIP_HESCs_Human0.86228665
149ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.86050896

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.12609013
2MP0005058_abnormal_lysosome_morphology4.65962119
3MP0004957_abnormal_blastocyst_morpholog3.92652727
4MP0003077_abnormal_cell_cycle3.70698414
5MP0003111_abnormal_nucleus_morphology3.67160649
6MP0008260_abnormal_autophagy3.64697061
7MP0003705_abnormal_hypodermis_morpholog3.58082267
8MP0008007_abnormal_cellular_replicative3.48618065
9MP0010094_abnormal_chromosome_stability3.38718317
10MP0002877_abnormal_melanocyte_morpholog3.16407163
11MP0008058_abnormal_DNA_repair3.11898100
12MP0005451_abnormal_body_composition2.77491088
13MP0002396_abnormal_hematopoietic_system2.77395415
14MP0008438_abnormal_cutaneous_collagen2.76564910
15MP0008057_abnormal_DNA_replication2.65068586
16MP0004858_abnormal_nervous_system2.48202347
17MP0005257_abnormal_intraocular_pressure2.47655455
18MP0003191_abnormal_cellular_cholesterol2.41463826
19MP0008932_abnormal_embryonic_tissue2.40423643
20MP0010030_abnormal_orbit_morphology2.33467938
21MP0001730_embryonic_growth_arrest2.31681976
22MP0003436_decreased_susceptibility_to2.08291181
23MP0000350_abnormal_cell_proliferation2.06643764
24MP0003123_paternal_imprinting2.05494849
25MP0004808_abnormal_hematopoietic_stem2.05044261
26MP0005397_hematopoietic_system_phenotyp2.04400039
27MP0001545_abnormal_hematopoietic_system2.04400039
28MP0002653_abnormal_ependyma_morphology1.97391561
29MP0003172_abnormal_lysosome_physiology1.96274471
30MP0003566_abnormal_cell_adhesion1.94660527
31MP0003786_premature_aging1.92920485
32MP0009333_abnormal_splenocyte_physiolog1.90528008
33MP0000490_abnormal_crypts_of1.85525858
34MP0001542_abnormal_bone_strength1.71857337
35MP0004233_abnormal_muscle_weight1.71113944
36MP0001697_abnormal_embryo_size1.66319677
37MP0006292_abnormal_olfactory_placode1.64873641
38MP0000313_abnormal_cell_death1.63467563
39MP0001672_abnormal_embryogenesis/_devel1.62129803
40MP0005380_embryogenesis_phenotype1.62129803
41MP0002080_prenatal_lethality1.61694521
42MP0003279_aneurysm1.59326915
43MP0003984_embryonic_growth_retardation1.53042300
44MP0006054_spinal_hemorrhage1.51387634
45MP0002132_abnormal_respiratory_system1.47969690
46MP0002088_abnormal_embryonic_growth/wei1.46655587
47MP0008995_early_reproductive_senescence1.45755466
48MP0004510_myositis1.43030852
49MP0003567_abnormal_fetal_cardiomyocyte1.42496999
50MP0003718_maternal_effect1.42436687
51MP0006082_CNS_inflammation1.41786348
52MP0005501_abnormal_skin_physiology1.41450707
53MP0003453_abnormal_keratinocyte_physiol1.41095986
54MP0005623_abnormal_meninges_morphology1.40108254
55MP0002085_abnormal_embryonic_tissue1.37515372
56MP0003763_abnormal_thymus_physiology1.36820621
57MP0002019_abnormal_tumor_incidence1.35447454
58MP0003303_peritoneal_inflammation1.33567461
59MP0003329_amyloid_beta_deposits1.26347602
60MP0005464_abnormal_platelet_physiology1.23342997
61MP0003186_abnormal_redox_activity1.22807866
62MP0002084_abnormal_developmental_patter1.22359105
63MP0003091_abnormal_cell_migration1.20608182
64MP0004947_skin_inflammation1.20472732
65MP0002398_abnormal_bone_marrow1.20427841
66MP0004185_abnormal_adipocyte_glucose1.20198169
67MP0002722_abnormal_immune_system1.19081144
68MP0000358_abnormal_cell_content/1.18920736
69MP0004272_abnormal_basement_membrane1.16576356
70MP0002086_abnormal_extraembryonic_tissu1.15874752
71MP0000681_abnormal_thyroid_gland1.15843875
72MP0000685_abnormal_immune_system1.15465748
73MP0001293_anophthalmia1.13483571
74MP0003075_altered_response_to1.13207607
75MP0003315_abnormal_perineum_morphology1.12798939
76MP0000689_abnormal_spleen_morphology1.11644664
77MP0002148_abnormal_hypersensitivity_rea1.11590826
78MP0003448_altered_tumor_morphology1.09977207
79MP0002060_abnormal_skin_morphology1.08948357
80MP0000751_myopathy1.08756337
81MP0002796_impaired_skin_barrier1.08693086
82MP0002210_abnormal_sex_determination1.08656425
83MP0000703_abnormal_thymus_morphology1.08117623
84MP0008877_abnormal_DNA_methylation1.07517731
85MP0001348_abnormal_lacrimal_gland1.07333740
86MP0001958_emphysema1.06450067
87MP0004197_abnormal_fetal_growth/weight/1.05825425
88MP0005025_abnormal_response_to1.04809329
89MP0002419_abnormal_innate_immunity1.03716371
90MP0000015_abnormal_ear_pigmentation1.02402160
91MP0008789_abnormal_olfactory_epithelium1.02199733
92MP0000733_abnormal_muscle_development1.01983658
93MP0006035_abnormal_mitochondrial_morpho1.01765089
94MP0010352_gastrointestinal_tract_polyps1.01367534
95MP0003656_abnormal_erythrocyte_physiolo1.00842176
96MP0002429_abnormal_blood_cell0.99246163
97MP0001915_intracranial_hemorrhage0.98484396
98MP0003943_abnormal_hepatobiliary_system0.98008940
99MP0005000_abnormal_immune_tolerance0.95620275
100MP0001881_abnormal_mammary_gland0.95252457
101MP0006036_abnormal_mitochondrial_physio0.94072430
102MP0001849_ear_inflammation0.93851759
103MP0002102_abnormal_ear_morphology0.93808861
104MP0001145_abnormal_male_reproductive0.92599289
105MP0003221_abnormal_cardiomyocyte_apopto0.91386146
106MP0003119_abnormal_digestive_system0.90360332
107MP0000604_amyloidosis0.88768418
108MP0001119_abnormal_female_reproductive0.87801151
109MP0003121_genomic_imprinting0.87473532
110MP0001986_abnormal_taste_sensitivity0.87442115
111MP0003646_muscle_fatigue0.86405751
112MP0000759_abnormal_skeletal_muscle0.86277715
113MP0003122_maternal_imprinting0.86043853
114MP0005390_skeleton_phenotype0.85380084
115MP0005384_cellular_phenotype0.85286644
116MP0001533_abnormal_skeleton_physiology0.84714386
117MP0009379_abnormal_foot_pigmentation0.83778708
118MP0002998_abnormal_bone_remodeling0.83570829
119MP0005508_abnormal_skeleton_morphology0.83418240
120MP0004084_abnormal_cardiac_muscle0.83309350
121MP0000747_muscle_weakness0.82138318
122MP0010307_abnormal_tumor_latency0.81842145
123MP0005171_absent_coat_pigmentation0.81551142
124MP0005621_abnormal_cell_physiology0.81333184
125MP0001853_heart_inflammation0.81033422
126MP0005076_abnormal_cell_differentiation0.80410681
127MP0005330_cardiomyopathy0.79002678
128MP0000716_abnormal_immune_system0.78424529
129MP0002938_white_spotting0.78423012
130MP0005266_abnormal_metabolism0.78102971
131MP0000858_altered_metastatic_potential0.77868472
132MP0005023_abnormal_wound_healing0.77851397
133MP0000465_gastrointestinal_hemorrhage0.77409737
134MP0002723_abnormal_immune_serum0.77377352
135MP0000653_abnormal_sex_gland0.76543727
136MP0000049_abnormal_middle_ear0.76248759
137MP0009931_abnormal_skin_appearance0.75379838
138MP0000767_abnormal_smooth_muscle0.75242477
139MP0002405_respiratory_system_inflammati0.75159509
140MP0001819_abnormal_immune_cell0.73442319
141MP0001929_abnormal_gametogenesis0.73107362
142MP0003806_abnormal_nucleotide_metabolis0.72976241
143MP0002420_abnormal_adaptive_immunity0.72404599
144MP0001661_extended_life_span0.72295032
145MP0000678_abnormal_parathyroid_gland0.72043523
146MP0001243_abnormal_dermal_layer0.71888141
147MP0000750_abnormal_muscle_regeneration0.71844871
148MP0010368_abnormal_lymphatic_system0.71708660
149MP0009053_abnormal_anal_canal0.71485294
150MP0002452_abnormal_antigen_presenting0.71275430
151MP0001727_abnormal_embryo_implantation0.71214196
152MP0002089_abnormal_postnatal_growth/wei0.68080398
153MP0002163_abnormal_gland_morphology0.67891098
154MP0001216_abnormal_epidermal_layer0.67746893
155MP0002127_abnormal_cardiovascular_syste0.67519286
156MP0009785_altered_susceptibility_to0.67459500
157MP0009278_abnormal_bone_marrow0.67354419
158MP0002249_abnormal_larynx_morphology0.66560826
159MP0009840_abnormal_foam_cell0.66389545
160MP0002751_abnormal_autonomic_nervous0.66363831
161MP0000343_altered_response_to0.65470520
162MP0005075_abnormal_melanosome_morpholog0.64994918
163MP0002160_abnormal_reproductive_system0.64730315
164MP0009697_abnormal_copulation0.63680349
165MP0004133_heterotaxia0.62030891

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)4.82884037
2Abnormality of cells of the erythroid lineage (HP:0012130)4.71078732
3Degeneration of anterior horn cells (HP:0002398)4.29819137
4Abnormality of the anterior horn cell (HP:0006802)4.29819137
5Aplastic anemia (HP:0001915)4.01075851
6Premature rupture of membranes (HP:0001788)3.97559822
7Reticulocytopenia (HP:0001896)3.93725894
8Birth length less than 3rd percentile (HP:0003561)3.80760990
9Microretrognathia (HP:0000308)3.78585832
10Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.78529624
11Decreased activity of mitochondrial respiratory chain (HP:0008972)3.78529624
12Oral leukoplakia (HP:0002745)3.76537948
13Abnormality of liposaccharide metabolism (HP:0010968)3.62556207
14Abnormality of glycosphingolipid metabolism (HP:0004343)3.62556207
15Abnormality of glycolipid metabolism (HP:0010969)3.62556207
16Breast hypoplasia (HP:0003187)3.52303006
17Cerebral hypomyelination (HP:0006808)3.48817857
18Upper limb amyotrophy (HP:0009129)3.30788565
19Distal upper limb amyotrophy (HP:0007149)3.30788565
20Achilles tendon contracture (HP:0001771)3.28129827
21Type I transferrin isoform profile (HP:0003642)3.20639846
22Thrombocytosis (HP:0001894)3.16859009
23Selective tooth agenesis (HP:0001592)3.16394817
24Hand muscle atrophy (HP:0009130)3.10379455
25Cholecystitis (HP:0001082)3.06238568
26Abnormal gallbladder physiology (HP:0012438)3.06238568
27Rough bone trabeculation (HP:0100670)3.03219216
28Hyperacusis (HP:0010780)3.02268094
29Atrophy/Degeneration involving motor neurons (HP:0007373)2.96658414
30Patellar aplasia (HP:0006443)2.95053142
31Multiple enchondromatosis (HP:0005701)2.94049287
32Colon cancer (HP:0003003)2.93219116
3311 pairs of ribs (HP:0000878)2.90497094
34Reduced antithrombin III activity (HP:0001976)2.89577781
35Aplasia/Hypoplasia of the patella (HP:0006498)2.88726647
36Trismus (HP:0000211)2.87384870
37Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.77039732
38Abnormal protein N-linked glycosylation (HP:0012347)2.77039732
39Abnormal protein glycosylation (HP:0012346)2.77039732
40Abnormal glycosylation (HP:0012345)2.77039732
41Hypertensive crisis (HP:0100735)2.72638888
42Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.71301385
43Abnormality of alanine metabolism (HP:0010916)2.71301385
44Hyperalaninemia (HP:0003348)2.71301385
45Abnormality of the Achilles tendon (HP:0005109)2.70998505
46Carpal bone hypoplasia (HP:0001498)2.67464965
47Progressive muscle weakness (HP:0003323)2.66446932
48Generalized amyotrophy (HP:0003700)2.65917523
49Dysostosis multiplex (HP:0000943)2.59868321
50Pallor (HP:0000980)2.57492784
51Axonal loss (HP:0003447)2.56457515
52Insomnia (HP:0100785)2.55068037
53Poor head control (HP:0002421)2.54994856
54Spinal rigidity (HP:0003306)2.51250773
55Distal lower limb muscle weakness (HP:0009053)2.50061841
56Long palpebral fissure (HP:0000637)2.48323048
57Macrocytic anemia (HP:0001972)2.46402190
58Increased serum lactate (HP:0002151)2.40609387
59Increased cerebral lipofuscin (HP:0011813)2.38938594
60Loss of speech (HP:0002371)2.36851703
61Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.34139954
62Neoplasm of the pancreas (HP:0002894)2.33884695
63Hepatocellular necrosis (HP:0001404)2.33554610
64Muscle fiber atrophy (HP:0100295)2.31226745
65Slender long bone (HP:0003100)2.30935335
66Glossoptosis (HP:0000162)2.30488217
67Vacuolated lymphocytes (HP:0001922)2.27085570
68Upper limb muscle weakness (HP:0003484)2.25876341
69Premature ovarian failure (HP:0008209)2.25163179
70Prolonged neonatal jaundice (HP:0006579)2.24177480
71Death in infancy (HP:0001522)2.23693649
72Ulnar bowing (HP:0003031)2.23014804
73Increased connective tissue (HP:0009025)2.21264264
74Upper motor neuron abnormality (HP:0002127)2.21079625
75Abnormality of macrophages (HP:0004311)2.19329023
76Type 2 muscle fiber atrophy (HP:0003554)2.18908970
77Abnormal number of incisors (HP:0011064)2.18729916
78Abnormality of the distal phalanges of the toes (HP:0010182)2.17320735
79Elbow flexion contracture (HP:0002987)2.15691291
80Postnatal microcephaly (HP:0005484)2.15580187
81Genu recurvatum (HP:0002816)2.15440785
82Secondary amenorrhea (HP:0000869)2.14660483
83Short nail (HP:0001799)2.14043397
84Abnormality of mucopolysaccharide metabolism (HP:0011020)2.13904264
85Abnormality of polysaccharide metabolism (HP:0011012)2.13904264
86Abnormality of glycosaminoglycan metabolism (HP:0004371)2.13904264
87Ankle contracture (HP:0006466)2.13391888
88Truncus arteriosus (HP:0001660)2.13268048
89Abnormality of the heme biosynthetic pathway (HP:0010472)2.13262978
90J-shaped sella turcica (HP:0002680)2.11205601
91Tongue fasciculations (HP:0001308)2.10257090
92Distal lower limb amyotrophy (HP:0008944)2.08877158
93Exertional dyspnea (HP:0002875)2.08657045
94Cervical subluxation (HP:0003308)2.08643225
95Premature graying of hair (HP:0002216)2.07816164
96CNS hypomyelination (HP:0003429)2.06594428
97Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.06206240
98Premature skin wrinkling (HP:0100678)2.06030543
99Unsteady gait (HP:0002317)2.05008495
100Absent thumb (HP:0009777)2.04493674
101Abnormal trabecular bone morphology (HP:0100671)2.04373587
102Myopathic facies (HP:0002058)2.04078454
103Stridor (HP:0010307)2.02105614
104Difficulty climbing stairs (HP:0003551)2.01969613
105Vertebral compression fractures (HP:0002953)1.99952165
106Increased neuronal autofluorescent lipopigment (HP:0002074)1.99296379
107Cleft eyelid (HP:0000625)1.99262525
108Muscle fibrillation (HP:0010546)1.98770776
109Abnormal neuron morphology (HP:0012757)1.98303291
110Abnormality of the motor neurons (HP:0002450)1.98303291
111Bulbar palsy (HP:0001283)1.98163597
112Fragile skin (HP:0001030)1.97932914
113Personality changes (HP:0000751)1.97725150
114Supranuclear gaze palsy (HP:0000605)1.97660588
115Male infertility (HP:0003251)1.97643038
116Acute lymphatic leukemia (HP:0006721)1.97592099
117Neuronal loss in central nervous system (HP:0002529)1.96271749
118Optic nerve coloboma (HP:0000588)1.94693116
119Abnormality of the tricuspid valve (HP:0001702)1.94059737
120Disproportionate tall stature (HP:0001519)1.93740830
121Reticulocytosis (HP:0001923)1.93597650
122Ragged-red muscle fibers (HP:0003200)1.92652395
123Nuclear cataract (HP:0100018)1.91151587
124Progressive neurologic deterioration (HP:0002344)1.90844826
125Biconcave vertebral bodies (HP:0004586)1.89994710
126Hepatic necrosis (HP:0002605)1.89760749
127Abnormality of the umbilical cord (HP:0010881)1.88699674
128Hepatosplenomegaly (HP:0001433)1.88648898
129Blue sclerae (HP:0000592)1.88425809
130Urinary glycosaminoglycan excretion (HP:0003541)1.86063320
131Mucopolysacchariduria (HP:0008155)1.86063320
132Hypoplasia of the capital femoral epiphysis (HP:0003090)1.86029379
133Tracheoesophageal fistula (HP:0002575)1.85869935
134Hypokinesia (HP:0002375)1.85630128
135Centrally nucleated skeletal muscle fibers (HP:0003687)1.84855912
136IgM deficiency (HP:0002850)1.84548632
137Joint stiffness (HP:0001387)1.82886871
138Deformed tarsal bones (HP:0008119)1.82813385
139Reduced subcutaneous adipose tissue (HP:0003758)1.82287457
140Flattened epiphyses (HP:0003071)1.81609555
141Pancytopenia (HP:0001876)1.80925403
142Protrusio acetabuli (HP:0003179)1.80661151
143Testicular atrophy (HP:0000029)1.80440268
144Atresia of the external auditory canal (HP:0000413)1.78976309
145Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.78357762
146Broad distal phalanx of finger (HP:0009836)1.77808629
147Missing ribs (HP:0000921)1.77739852
148Calcaneovalgus deformity (HP:0001848)1.77141594
149Atrophic scars (HP:0001075)1.77091145
150Microvesicular hepatic steatosis (HP:0001414)1.75035144
151Mitral regurgitation (HP:0001653)1.74561457
152Cholelithiasis (HP:0001081)1.73620199
153Atelectasis (HP:0100750)1.73455886
154Nonimmune hydrops fetalis (HP:0001790)1.73430091
155Delusions (HP:0000746)1.73349446
156Increased serum ferritin (HP:0003281)1.72700990
157Aplasia/Hypoplasia of the sacrum (HP:0008517)1.72307337
158Cellulitis (HP:0100658)1.71571270
159Bladder diverticulum (HP:0000015)1.71281681
160Abnormality of the ileum (HP:0001549)1.70381956
161Myelodysplasia (HP:0002863)1.70244797
162Spastic paraparesis (HP:0002313)1.69763111
163Increased intramyocellular lipid droplets (HP:0012240)1.69548863
164Meckel diverticulum (HP:0002245)1.69511442
165Increased serum pyruvate (HP:0003542)1.68981282
166Abnormality of glycolysis (HP:0004366)1.68981282
167Elevated erythrocyte sedimentation rate (HP:0003565)1.68767600
168Respiratory difficulties (HP:0002880)1.68651006
169Petechiae (HP:0000967)1.68556771
170Lactic acidosis (HP:0003128)1.68553008
171Diminished motivation (HP:0000745)1.67883516
172Abnormal umbilical cord blood vessels (HP:0011403)1.67505365
173Single umbilical artery (HP:0001195)1.67505365
174Abnormality of the fetal cardiovascular system (HP:0010948)1.67505365
175Pendular nystagmus (HP:0012043)1.67063864
176Hypoplasia of the radius (HP:0002984)1.65700976
177Diaphragmatic weakness (HP:0009113)1.65620394
178Entropion (HP:0000621)1.64970006
179Slender build (HP:0001533)1.64960083
180Cerebral aneurysm (HP:0004944)1.64831169
181Neoplasm of head and neck (HP:0012288)1.64635725
182Esophageal neoplasm (HP:0100751)1.64635725
183Cellular immunodeficiency (HP:0005374)1.64140415
184Emotional lability (HP:0000712)1.63611834
185Bone marrow hypocellularity (HP:0005528)1.62081457
186Horseshoe kidney (HP:0000085)1.61368349

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.14310197
2WEE14.13428196
3NME23.72972642
4IRAK33.08106297
5STK162.99755714
6SMG12.93668046
7PRPF4B2.85825975
8ACVR1B2.54597187
9NEK22.49211483
10EIF2AK12.40635527
11TESK22.31403967
12PKN22.11477833
13VRK22.06935513
14SRPK12.05831438
15ICK2.00808536
16CDC71.97735361
17DYRK31.93939794
18PASK1.91957669
19CCNB11.91644916
20PIM21.89526695
21NEK11.88365095
22SIK11.85282608
23KDR1.83652447
24TRIB31.74589694
25EPHA21.70356935
26RPS6KA41.67625112
27MAPKAPK31.66606345
28BRSK21.62817157
29MAP3K111.62378828
30FLT31.58702837
31SCYL21.58253515
32TSSK61.55541314
33ARAF1.55393398
34VRK11.54284842
35CDK71.48430670
36BRSK11.42399108
37PAK41.41719536
38PRKD31.41516684
39TLK11.36115101
40RPS6KB21.35972045
41EEF2K1.35708325
42TESK11.33980817
43PLK11.32812554
44LATS21.32343540
45TGFBR11.26873663
46ABL21.24916384
47BRAF1.24911257
48MAP3K121.16757934
49LMTK21.16218212
50BCKDK1.15911587
51MAP3K101.15588298
52AURKA1.14074604
53EIF2AK31.09877001
54CDK191.08916297
55KSR11.05451630
56EPHB21.03500743
57DYRK21.01787369
58KSR21.01540618
59AURKB1.01279021
60RAF11.00347112
61PRKD20.99571330
62TTN0.95191613
63KIT0.93304382
64ZAP700.92295280
65MAP4K10.91700439
66BMX0.91293692
67TBK10.90323426
68ERN10.87391933
69ATR0.87303483
70EPHB10.86617356
71MAP3K10.85631550
72LRRK20.84146279
73CHEK20.83283694
74ILK0.82851205
75PTK20.82355045
76MAP3K130.80222586
77LIMK10.79826530
78CAMKK20.78952645
79MUSK0.78194558
80DAPK10.77572055
81IRAK20.75221937
82CDK40.73449873
83DAPK30.73256909
84PAK10.72303319
85NME10.71276837
86PLK30.70246224
87MAP3K60.69823433
88TAOK20.68010837
89PBK0.66706263
90CDK80.65270598
91GRK60.65010050
92MAP3K80.64313404
93PLK40.64211238
94TAOK10.63095019
95PAK60.62472374
96SIK30.62436680
97CDK11A0.62023066
98WNK30.61641145
99PTK60.59204463
100DDR20.58865044
101MAP3K90.57067711
102CDK140.56680093
103RPS6KA20.56329930
104CHEK10.53661863
105PDPK10.53542780
106PDGFRA0.53325582
107CDK150.50990685
108NTRK10.50634346
109MAP2K30.50625393
110MKNK10.49498013
111MARK20.48656851
112PRKG20.48155208
113BLK0.48075933
114SIK20.47923904
115IRAK40.47033741
116CDK180.46980072
117TTK0.46124990
118PIM10.45982448
119BTK0.45229813
120CAMKK10.45208587
121CSNK2A10.44784497
122PRKCI0.44573295
123STK100.44383178
124JAK30.44292578
125RPS6KL10.43456697
126RPS6KC10.43456697
127MTOR0.42782017
128CSNK2A20.42482172
129PAK20.42145704
130CDC42BPA0.41359750
131NLK0.41253949
132MAP2K20.40846436
133CSF1R0.40492946
134STK40.39438946
135MAPKAPK20.39421553
136CDK20.38970190
137STK240.38125207
138CDK120.37140017
139TGFBR20.36375794
140ZAK0.36348912
141AKT20.33751497
142DYRK1B0.32659427
143MST1R0.31883587
144RIPK10.31513564
145MOS0.31416141
146MKNK20.30863228
147SYK0.30519339
148TYK20.29683881
149CAMK2G0.28382498
150MAP3K30.26601124
151MAPK110.24387767
152CSNK1G30.22087897

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.61511675
2Proteasome_Homo sapiens_hsa030503.94867872
3Ribosome_Homo sapiens_hsa030103.94814428
4RNA polymerase_Homo sapiens_hsa030203.79124321
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.51503655
6Spliceosome_Homo sapiens_hsa030403.30974822
7Mismatch repair_Homo sapiens_hsa034303.28493306
8Base excision repair_Homo sapiens_hsa034103.11521524
9RNA transport_Homo sapiens_hsa030132.90838843
10Pyrimidine metabolism_Homo sapiens_hsa002402.88678427
11Other glycan degradation_Homo sapiens_hsa005112.80137073
12Cell cycle_Homo sapiens_hsa041102.59276456
13Glycosaminoglycan degradation_Homo sapiens_hsa005312.42621486
14Nucleotide excision repair_Homo sapiens_hsa034202.40369379
15Homologous recombination_Homo sapiens_hsa034402.32609505
16Lysosome_Homo sapiens_hsa041422.08010461
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.94993907
18RNA degradation_Homo sapiens_hsa030181.90557984
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.86386575
20Sulfur relay system_Homo sapiens_hsa041221.85736805
21Vibrio cholerae infection_Homo sapiens_hsa051101.83921536
22Basal transcription factors_Homo sapiens_hsa030221.70776072
23Pentose phosphate pathway_Homo sapiens_hsa000301.68138663
24p53 signaling pathway_Homo sapiens_hsa041151.59093415
25Purine metabolism_Homo sapiens_hsa002301.56021646
26One carbon pool by folate_Homo sapiens_hsa006701.40884438
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.39962362
28Folate biosynthesis_Homo sapiens_hsa007901.38638694
29Biosynthesis of amino acids_Homo sapiens_hsa012301.30921960
30Fanconi anemia pathway_Homo sapiens_hsa034601.30325200
31mRNA surveillance pathway_Homo sapiens_hsa030151.27469817
32Prion diseases_Homo sapiens_hsa050201.24503142
33Epstein-Barr virus infection_Homo sapiens_hsa051691.23402756
34Non-homologous end-joining_Homo sapiens_hsa034501.21817428
35Cyanoamino acid metabolism_Homo sapiens_hsa004601.15422264
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.15393593
37Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.14323303
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.14163767
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.11894155
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.10034683
41Toll-like receptor signaling pathway_Homo sapiens_hsa046201.09558211
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.08235903
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.08090797
44Synaptic vesicle cycle_Homo sapiens_hsa047211.07451341
45Endocytosis_Homo sapiens_hsa041441.07399017
46Pancreatic cancer_Homo sapiens_hsa052121.05819994
47Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.97544873
48N-Glycan biosynthesis_Homo sapiens_hsa005100.97530205
49Oocyte meiosis_Homo sapiens_hsa041140.95115822
50Herpes simplex infection_Homo sapiens_hsa051680.93983309
51Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.92686106
52VEGF signaling pathway_Homo sapiens_hsa043700.91841623
53Non-small cell lung cancer_Homo sapiens_hsa052230.88521476
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.87646055
55Thyroid cancer_Homo sapiens_hsa052160.87633982
56Osteoclast differentiation_Homo sapiens_hsa043800.84056639
57Phagosome_Homo sapiens_hsa041450.84041669
58Carbon metabolism_Homo sapiens_hsa012000.83822181
59Huntingtons disease_Homo sapiens_hsa050160.83136343
60Shigellosis_Homo sapiens_hsa051310.82679213
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81602139
62Parkinsons disease_Homo sapiens_hsa050120.80847181
63Sulfur metabolism_Homo sapiens_hsa009200.80551273
64Galactose metabolism_Homo sapiens_hsa000520.79920307
65Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.76960345
66Fatty acid elongation_Homo sapiens_hsa000620.76719423
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.76349103
68Legionellosis_Homo sapiens_hsa051340.74379446
69Vitamin B6 metabolism_Homo sapiens_hsa007500.73175208
70HTLV-I infection_Homo sapiens_hsa051660.72742538
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70993892
72Malaria_Homo sapiens_hsa051440.69876772
73Notch signaling pathway_Homo sapiens_hsa043300.64274312
74Viral carcinogenesis_Homo sapiens_hsa052030.63728159
75TNF signaling pathway_Homo sapiens_hsa046680.61496765
76NF-kappa B signaling pathway_Homo sapiens_hsa040640.60614810
77Protein export_Homo sapiens_hsa030600.60349915
78Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59574513
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59170399
80Fructose and mannose metabolism_Homo sapiens_hsa000510.56004843
81Antigen processing and presentation_Homo sapiens_hsa046120.54863485
82B cell receptor signaling pathway_Homo sapiens_hsa046620.53978641
83Bladder cancer_Homo sapiens_hsa052190.53134980
84Tuberculosis_Homo sapiens_hsa051520.52988954
85Proteoglycans in cancer_Homo sapiens_hsa052050.52550739
86Hepatitis C_Homo sapiens_hsa051600.51711955
87Insulin signaling pathway_Homo sapiens_hsa049100.50469239
88mTOR signaling pathway_Homo sapiens_hsa041500.46968138
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.46801617
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46460048
91Glutathione metabolism_Homo sapiens_hsa004800.45799180
92Renal cell carcinoma_Homo sapiens_hsa052110.45775226
93Central carbon metabolism in cancer_Homo sapiens_hsa052300.45148024
94Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.45054347
95Hepatitis B_Homo sapiens_hsa051610.44513110
96Focal adhesion_Homo sapiens_hsa045100.44082583
97Glioma_Homo sapiens_hsa052140.43483945
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42935661
99Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.42655954
100Endometrial cancer_Homo sapiens_hsa052130.42034123
101Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.41741891
102HIF-1 signaling pathway_Homo sapiens_hsa040660.41564937
103Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41199127
104Apoptosis_Homo sapiens_hsa042100.39626413
105Acute myeloid leukemia_Homo sapiens_hsa052210.39495819
106Systemic lupus erythematosus_Homo sapiens_hsa053220.39385245
107Oxidative phosphorylation_Homo sapiens_hsa001900.38692728
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38552022
109Measles_Homo sapiens_hsa051620.36682322
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36024644
111Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.35669279
112Hippo signaling pathway_Homo sapiens_hsa043900.34728374
113Primary immunodeficiency_Homo sapiens_hsa053400.34578795
114Selenocompound metabolism_Homo sapiens_hsa004500.33937200
115Colorectal cancer_Homo sapiens_hsa052100.33497289
116Small cell lung cancer_Homo sapiens_hsa052220.33202881
117Regulation of autophagy_Homo sapiens_hsa041400.31702081
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.31621255
119Chronic myeloid leukemia_Homo sapiens_hsa052200.27522976
120Basal cell carcinoma_Homo sapiens_hsa052170.26768308
121Metabolic pathways_Homo sapiens_hsa011000.26752159
122Influenza A_Homo sapiens_hsa051640.25867307
123Leishmaniasis_Homo sapiens_hsa051400.25765159
124Phototransduction_Homo sapiens_hsa047440.25294125
125TGF-beta signaling pathway_Homo sapiens_hsa043500.24580111
126MicroRNAs in cancer_Homo sapiens_hsa052060.23272812
127Transcriptional misregulation in cancer_Homo sapiens_hsa052020.22936345
128Viral myocarditis_Homo sapiens_hsa054160.17889241
129Neurotrophin signaling pathway_Homo sapiens_hsa047220.17340540
130Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.16713656
131Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.14704925
132Alcoholism_Homo sapiens_hsa050340.14464858
133Arginine and proline metabolism_Homo sapiens_hsa003300.14341785
134Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.13322799
135Salmonella infection_Homo sapiens_hsa051320.12835110
136RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.12226225
137Pathways in cancer_Homo sapiens_hsa052000.12033267
138Jak-STAT signaling pathway_Homo sapiens_hsa046300.11627365
139Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.10342821

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