SNAPC4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the largest subunit of the small nuclear RNA-activating protein (SNAP) complex. The encoded protein contains a Myb DNA-binding domain, and is essential for RNA polymerase II and III polymerase transcription from small nuclear RNA promoters. A mutation in this gene is associated with ankylosing spondylitis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)5.28124168
2regulation of translational termination (GO:0006449)4.62964026
3mannose metabolic process (GO:0006013)4.59520524
4nuclear pore complex assembly (GO:0051292)4.58126833
5nuclear pore organization (GO:0006999)4.43362828
6negative regulation of histone methylation (GO:0031061)4.41805934
7regulation of translational fidelity (GO:0006450)4.31328389
8apoptotic process involved in morphogenesis (GO:0060561)4.20847649
9regulation of mammary gland epithelial cell proliferation (GO:0033599)4.10590409
10negative regulation of erythrocyte differentiation (GO:0045647)4.10321124
11activation of Rac GTPase activity (GO:0032863)3.92706267
12negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.83266963
13histone H4-K12 acetylation (GO:0043983)3.79757391
14DNA unwinding involved in DNA replication (GO:0006268)3.73097615
15folic acid-containing compound biosynthetic process (GO:0009396)3.72529523
16mitotic sister chromatid cohesion (GO:0007064)3.71195716
17semaphorin-plexin signaling pathway (GO:0071526)3.68437653
18adherens junction assembly (GO:0034333)3.64237650
19protein localization to kinetochore (GO:0034501)3.63981907
20NLS-bearing protein import into nucleus (GO:0006607)3.62573067
21positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.62040849
22IMP biosynthetic process (GO:0006188)3.56372542
233-UTR-mediated mRNA stabilization (GO:0070935)3.56304457
24cell-substrate adherens junction assembly (GO:0007045)3.54520260
25focal adhesion assembly (GO:0048041)3.54520260
26DNA duplex unwinding (GO:0032508)3.50760592
27peptidyl-lysine dimethylation (GO:0018027)3.49701003
28DNA geometric change (GO:0032392)3.48891596
29snRNA metabolic process (GO:0016073)3.47897586
30regulation of NFAT protein import into nucleus (GO:0051532)3.46688480
31positive regulation of histone deacetylation (GO:0031065)3.43204236
32histone H4-K5 acetylation (GO:0043981)3.39003218
33histone H4-K8 acetylation (GO:0043982)3.39003218
34pore complex assembly (GO:0046931)3.36999933
35histone H2A monoubiquitination (GO:0035518)3.34809104
36heterochromatin organization (GO:0070828)3.34272280
37nucleobase biosynthetic process (GO:0046112)3.32920292
38histone H4-K16 acetylation (GO:0043984)3.32601721
39spliceosomal tri-snRNP complex assembly (GO:0000244)3.32147107
40chromatin silencing (GO:0006342)3.32091436
41mitotic nuclear envelope disassembly (GO:0007077)3.29885918
42peptidyl-arginine omega-N-methylation (GO:0035247)3.29402886
43peptidyl-arginine N-methylation (GO:0035246)3.26163985
44peptidyl-arginine methylation (GO:0018216)3.26163985
45mitotic G1 DNA damage checkpoint (GO:0031571)3.24580546
46negative regulation of RNA splicing (GO:0033119)3.24256796
47regulation of histone H3-K9 methylation (GO:0051570)3.23963453
48glucocorticoid receptor signaling pathway (GO:0042921)3.20329872
49planar cell polarity pathway involved in neural tube closure (GO:0090179)3.18591831
50nuclear envelope disassembly (GO:0051081)3.17565887
51membrane disassembly (GO:0030397)3.17565887
52histone H3-K4 methylation (GO:0051568)3.17323772
53maternal placenta development (GO:0001893)3.17298726
54dosage compensation (GO:0007549)3.16643088
55regulation of posttranscriptional gene silencing (GO:0060147)3.16207115
56regulation of gene silencing by miRNA (GO:0060964)3.16207115
57regulation of gene silencing by RNA (GO:0060966)3.16207115
58regulation of ARF GTPase activity (GO:0032312)3.08332081
59negative regulation of mRNA metabolic process (GO:1903312)3.07608796
60regulation of RNA export from nucleus (GO:0046831)3.06442928
61negative regulation of mRNA processing (GO:0050686)3.03741158
62activation of MAPKKK activity (GO:0000185)3.01994151
63histone H3-K4 trimethylation (GO:0080182)3.01253609
64regulation of DNA damage checkpoint (GO:2000001)3.00799344
65intracellular estrogen receptor signaling pathway (GO:0030520)3.00456304
66sister chromatid segregation (GO:0000819)2.99859211
67snRNA processing (GO:0016180)2.98539254
68stress granule assembly (GO:0034063)2.98039158
69establishment of apical/basal cell polarity (GO:0035089)2.97728104
70synaptic vesicle docking involved in exocytosis (GO:0016081)2.97708883
71regulation of chromatin binding (GO:0035561)2.96419019
72mitotic sister chromatid segregation (GO:0000070)2.95998962
73histone H4 acetylation (GO:0043967)2.92775288
74regulation of nucleobase-containing compound transport (GO:0032239)2.92634098
75modulation by virus of host process (GO:0019054)2.90953712
76determination of adult lifespan (GO:0008340)2.90764971
77locomotory exploration behavior (GO:0035641)2.89802890
78negative regulation of viral release from host cell (GO:1902187)2.89318377
79modulation by symbiont of host cellular process (GO:0044068)2.88249347
80cell-substrate junction assembly (GO:0007044)2.87977770
81positive regulation of RNA splicing (GO:0033120)2.87850792
82histone lysine methylation (GO:0034968)2.87412478
83mRNA splice site selection (GO:0006376)2.86759054
84protein localization to chromosome, centromeric region (GO:0071459)2.86698706
85mRNA stabilization (GO:0048255)2.84784903
86RNA stabilization (GO:0043489)2.84784903
87histone methylation (GO:0016571)2.84277708
88proline biosynthetic process (GO:0006561)2.83071385
89negative regulation of gene expression, epigenetic (GO:0045814)2.81795509
90positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.81576464
91gene silencing (GO:0016458)2.80730159
92positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.80251627
93regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.80169346
94positive regulation of gene expression, epigenetic (GO:0045815)2.80015788
95apoptotic process involved in development (GO:1902742)2.79576379
96negative regulation of histone modification (GO:0031057)2.78896627
97regulation of mitotic spindle organization (GO:0060236)2.78647505
98histone lysine demethylation (GO:0070076)2.78087047
99cellular protein complex localization (GO:0034629)2.77718778
100IMP metabolic process (GO:0046040)2.77418493
101negative regulation of cell size (GO:0045792)2.77163167
102COPI coating of Golgi vesicle (GO:0048205)2.77145580
103Golgi transport vesicle coating (GO:0048200)2.77145580
104regulation of DNA endoreduplication (GO:0032875)2.76672677
105regulation of early endosome to late endosome transport (GO:2000641)2.75768906
106protein retention in ER lumen (GO:0006621)2.75277932
107purine nucleobase biosynthetic process (GO:0009113)2.73374659
108histone demethylation (GO:0016577)2.73250656
109regulation of translational elongation (GO:0006448)2.72868289
110mitotic G1/S transition checkpoint (GO:0044819)2.72531162
111histone H3-K36 demethylation (GO:0070544)2.72479634
112corticosteroid receptor signaling pathway (GO:0031958)2.71477141
113mRNA transport (GO:0051028)2.70859790
114peptidyl-lysine trimethylation (GO:0018023)2.70547430
115maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.70063264
116alternative mRNA splicing, via spliceosome (GO:0000380)2.69513566
117regulation of type I interferon-mediated signaling pathway (GO:0060338)2.69460133
118cellular response to epidermal growth factor stimulus (GO:0071364)2.69338909
119regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.68988435
120mitotic chromosome condensation (GO:0007076)2.68237478
121negative regulation of chromatin modification (GO:1903309)2.67584358
122regulation of short-term neuronal synaptic plasticity (GO:0048172)2.67495740
123chromatin assembly (GO:0031497)2.67347158
124epithelial cell differentiation involved in prostate gland development (GO:0060742)2.67026171
125regulation of nuclear cell cycle DNA replication (GO:0033262)2.66939084
126peptidyl-lysine methylation (GO:0018022)2.66664660
127G1 DNA damage checkpoint (GO:0044783)2.66377823
128negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.66369765
129negative regulation of cell killing (GO:0031342)2.66369765
130histone H4 deacetylation (GO:0070933)2.66222178
131protein localization to endosome (GO:0036010)2.64580775
132DNA replication-dependent nucleosome organization (GO:0034723)2.63954658
133DNA replication-dependent nucleosome assembly (GO:0006335)2.63954658
134DNA replication initiation (GO:0006270)2.62587958
135histone arginine methylation (GO:0034969)2.62501642
136regulation of histone H3-K27 methylation (GO:0061085)2.62301724
137intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.60831183
138negative regulation of DNA-templated transcription, elongation (GO:0032785)2.60708769
139regulation of glucose import in response to insulin stimulus (GO:2001273)2.60318718
140protein-DNA complex disassembly (GO:0032986)2.59819576
141nucleosome disassembly (GO:0006337)2.59819576
142chromosome condensation (GO:0030261)2.59353589
143retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.57104378
144regulation of histone methylation (GO:0031060)2.56947797
145positive regulation of chromosome segregation (GO:0051984)2.56909821
146ear development (GO:0043583)2.55910870
147protein export from nucleus (GO:0006611)2.55638965
148negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.55586866
149positive regulation of protein deacetylation (GO:0090312)2.55436861
150thymic T cell selection (GO:0045061)2.53362179
151positive regulation of Cdc42 GTPase activity (GO:0043089)2.53195348
152NIK/NF-kappaB signaling (GO:0038061)2.52768542
153protein complex localization (GO:0031503)2.52764844
154protein demethylation (GO:0006482)2.52422758
155protein dealkylation (GO:0008214)2.52422758
156cellular response to virus (GO:0098586)2.51775272
157cytoskeletal anchoring at plasma membrane (GO:0007016)2.51336731
158atrioventricular valve morphogenesis (GO:0003181)2.50896334
159histone H3 deacetylation (GO:0070932)2.49443385
160rRNA transcription (GO:0009303)2.48843338
161response to muramyl dipeptide (GO:0032495)2.45609945
162regulation of apoptotic process involved in morphogenesis (GO:1902337)2.45583516

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.26318889
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.31555672
3MYC_22102868_ChIP-Seq_BL_Human3.87831767
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.76530279
5CIITA_25753668_ChIP-Seq_RAJI_Human2.78335459
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.75521644
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.65144496
8EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.60134830
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.58730930
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.57608167
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.52141492
12* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.41933211
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.34984767
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.17595063
15CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat2.16734489
16VDR_21846776_ChIP-Seq_THP-1_Human2.11464400
17KDM2B_26808549_Chip-Seq_DND41_Human2.07374472
18E2F1_21310950_ChIP-Seq_MCF-7_Human2.03951114
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.97564677
20TCF7_22412390_ChIP-Seq_EML_Mouse1.97462750
21* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.94444833
22* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.91785337
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.84163951
24SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.80500247
25SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.79006403
26ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.72986739
27ZFP281_27345836_Chip-Seq_ESCs_Mouse1.72494279
28ZFP281_18757296_ChIP-ChIP_E14_Mouse1.71582902
29XRN2_22483619_ChIP-Seq_HELA_Human1.69754542
30CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.69573835
31RARG_19884340_ChIP-ChIP_MEFs_Mouse1.69032285
32KDM2B_26808549_Chip-Seq_SUP-B15_Human1.69023582
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.67690373
34* KDM5A_27292631_Chip-Seq_BREAST_Human1.66464221
35MYC_19030024_ChIP-ChIP_MESCs_Mouse1.66338964
36SMC4_20622854_ChIP-Seq_HELA_Human1.63210608
37TET1_21451524_ChIP-Seq_MESCs_Mouse1.62692347
38NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.62312256
39YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61695826
40ERG_21242973_ChIP-ChIP_JURKAT_Human1.59530012
41DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.55032776
42SALL1_21062744_ChIP-ChIP_HESCs_Human1.52482485
43DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.51918287
44POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.50759514
45CTCF_27219007_Chip-Seq_ERYTHROID_Human1.49562073
46RARB_27405468_Chip-Seq_BRAIN_Mouse1.49539580
47NANOG_18555785_ChIP-Seq_MESCs_Mouse1.48138623
48ESR1_15608294_ChIP-ChIP_MCF-7_Human1.47563626
49SA1_27219007_Chip-Seq_ERYTHROID_Human1.46411534
50* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.42985420
51* UTX_26944678_Chip-Seq_JUKART_Human1.42799373
52SRY_22984422_ChIP-ChIP_TESTIS_Rat1.42789404
53STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.42720991
54* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.42235614
55TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42163046
56TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.40434855
57PKCTHETA_26484144_Chip-Seq_BREAST_Human1.39403848
58VDR_24763502_ChIP-Seq_THP-1_Human1.38645592
59CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.37793581
60KDM2B_26808549_Chip-Seq_JURKAT_Human1.37616890
61* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.37613088
62THAP11_20581084_ChIP-Seq_MESCs_Mouse1.33514068
63CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.32900096
64* LXR_22292898_ChIP-Seq_THP-1_Human1.31722221
65* ELF1_20517297_ChIP-Seq_JURKAT_Human1.29886742
66HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.28772255
67CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.27772386
68TP63_19390658_ChIP-ChIP_HaCaT_Human1.26854096
69MAF_26560356_Chip-Seq_TH1_Human1.26492724
70KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.26275987
71KDM2B_26808549_Chip-Seq_K562_Human1.24393446
72KLF4_18555785_ChIP-Seq_MESCs_Mouse1.24293584
73ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.24181864
74KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.22630138
75PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.21980382
76E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.21216903
77EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.20954302
78NELFA_20434984_ChIP-Seq_ESCs_Mouse1.20617149
79STAT6_21828071_ChIP-Seq_BEAS2B_Human1.18933418
80CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.18928738
81ELK3_25401928_ChIP-Seq_HUVEC_Human1.18786652
82* BCOR_27268052_Chip-Seq_Bcells_Human1.18352386
83SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.18049409
84POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.17860998
85SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.17464669
86TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.16697123
87AR_21909140_ChIP-Seq_LNCAP_Human1.16692407
88TP53_22127205_ChIP-Seq_IMR90_Human1.16644293
89ETS1_20019798_ChIP-Seq_JURKAT_Human1.16115264
90RUNX1_27514584_Chip-Seq_MCF-7_Human1.15279997
91MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.14589996
92* NCOR1_26117541_ChIP-Seq_K562_Human1.14167616
93TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12410957
94* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12235630
95RUNX1_22412390_ChIP-Seq_EML_Mouse1.11229267
96WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.11055226
97ESR2_21235772_ChIP-Seq_MCF-7_Human1.11009271
98* CREB1_26743006_Chip-Seq_LNCaP_Human1.10561911
99* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.08273823
100RBPJ_22232070_ChIP-Seq_NCS_Mouse1.08263400
101MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.07974783
102ZFX_18555785_ChIP-Seq_MESCs_Mouse1.07973262
103* P68_20966046_ChIP-Seq_HELA_Human1.07946509
104ZNF263_19887448_ChIP-Seq_K562_Human1.07714925
105TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06794598
106SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.06242473
107* GABP_19822575_ChIP-Seq_HepG2_Human1.06197054
108* RARA_24833708_ChIP-Seq_LIVER_Mouse1.06133385
109NANOG_21062744_ChIP-ChIP_HESCs_Human1.05725129
110CTCF_27219007_Chip-Seq_Bcells_Human1.05719160
111P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04616865
112MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.03896540
113GATA1_22383799_ChIP-Seq_G1ME_Mouse1.03809872
114MYB_26560356_Chip-Seq_TH1_Human1.03763920
115FOXP3_21729870_ChIP-Seq_TREG_Human1.02583719
116* BCL6_27268052_Chip-Seq_Bcells_Human1.01702192
117TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.00823065
118TFEB_21752829_ChIP-Seq_HELA_Human1.00195276
119DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00171088
120BRD4_27068464_Chip-Seq_AML-cells_Mouse1.00070226
121TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.99929923
122RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.99655216
123MAF_26560356_Chip-Seq_TH2_Human0.99498224
124PU.1_20513432_ChIP-Seq_Bcells_Mouse0.99332049
125CTCF_26484167_Chip-Seq_Bcells_Mouse0.99320145
126RARB_24833708_ChIP-Seq_LIVER_Mouse0.99300857
127CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99179352
128ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.98518165
129HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.98126801
130STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97826060
131PHF8_20622854_ChIP-Seq_HELA_Human0.96209351
132ATF3_27146783_Chip-Seq_COLON_Human0.95233533
133BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.94979330
134* CHD1_26751641_Chip-Seq_LNCaP_Human0.94691057
135GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93415911
136KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.92948531
137TTF2_22483619_ChIP-Seq_HELA_Human0.91890151
138NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.90607002
139RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90381020
140MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.87923273
141* RACK7_27058665_Chip-Seq_MCF-7_Human0.87731944
142YY1_21170310_ChIP-Seq_MESCs_Mouse0.87205194

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003111_abnormal_nucleus_morphology3.51610319
2MP0003693_abnormal_embryo_hatching3.39286366
3MP0000569_abnormal_digit_pigmentation3.22369539
4MP0004859_abnormal_synaptic_plasticity3.19491063
5MP0010094_abnormal_chromosome_stability3.15971471
6MP0003123_paternal_imprinting2.83418778
7MP0005451_abnormal_body_composition2.83369466
8MP0004957_abnormal_blastocyst_morpholog2.79454518
9MP0003787_abnormal_imprinting2.72144748
10MP0008057_abnormal_DNA_replication2.70996942
11MP0000678_abnormal_parathyroid_gland2.69881879
12MP0003077_abnormal_cell_cycle2.68550074
13MP0001348_abnormal_lacrimal_gland2.57084008
14MP0002249_abnormal_larynx_morphology2.44722014
15MP0010352_gastrointestinal_tract_polyps2.38931878
16MP0008260_abnormal_autophagy2.38113140
17MP0005076_abnormal_cell_differentiation2.37015263
18MP0004185_abnormal_adipocyte_glucose2.25372160
19MP0001730_embryonic_growth_arrest2.24771509
20MP0008877_abnormal_DNA_methylation2.24292738
21MP0010307_abnormal_tumor_latency2.22160008
22MP0000350_abnormal_cell_proliferation2.06161257
23MP0002396_abnormal_hematopoietic_system2.04677138
24MP0005058_abnormal_lysosome_morphology2.02668300
25MP0008961_abnormal_basal_metabolism1.96565026
26MP0003121_genomic_imprinting1.95379425
27MP0005380_embryogenesis_phenotype1.83054661
28MP0001672_abnormal_embryogenesis/_devel1.83054661
29MP0004197_abnormal_fetal_growth/weight/1.78649424
30MP0000537_abnormal_urethra_morphology1.78591742
31MP0003453_abnormal_keratinocyte_physiol1.78234578
32MP0008058_abnormal_DNA_repair1.76796829
33MP0003984_embryonic_growth_retardation1.75573620
34MP0003705_abnormal_hypodermis_morpholog1.73821851
35MP0002088_abnormal_embryonic_growth/wei1.70757720
36MP0002084_abnormal_developmental_patter1.69274490
37MP0003763_abnormal_thymus_physiology1.64022403
38MP0001873_stomach_inflammation1.63109654
39MP0002080_prenatal_lethality1.61105652
40MP0004233_abnormal_muscle_weight1.60228849
41MP0001697_abnormal_embryo_size1.59806790
42MP0002085_abnormal_embryonic_tissue1.57420710
43MP0002086_abnormal_extraembryonic_tissu1.56534628
44MP0003890_abnormal_embryonic-extraembry1.56323181
45MP0004808_abnormal_hematopoietic_stem1.55747934
46MP0005623_abnormal_meninges_morphology1.54878551
47MP0009333_abnormal_splenocyte_physiolog1.52694388
48MP0000703_abnormal_thymus_morphology1.47666370
49MP0005409_darkened_coat_color1.46380349
50MP0003635_abnormal_synaptic_transmissio1.41877817
51MP0003436_decreased_susceptibility_to1.40006638
52MP0003283_abnormal_digestive_organ1.38775787
53MP0009672_abnormal_birth_weight1.38368572
54MP0008007_abnormal_cellular_replicative1.35129469
55MP0002653_abnormal_ependyma_morphology1.32765750
56MP0003119_abnormal_digestive_system1.28286193
57MP0005666_abnormal_adipose_tissue1.28209193
58MP0002796_impaired_skin_barrier1.27304881
59MP0010030_abnormal_orbit_morphology1.27223634
60MP0009703_decreased_birth_body1.24631183
61MP0005501_abnormal_skin_physiology1.23619769
62MP0003091_abnormal_cell_migration1.22224001
63MP0001849_ear_inflammation1.20241407
64MP0004381_abnormal_hair_follicle1.19963822
65MP0000003_abnormal_adipose_tissue1.19134164
66MP0004947_skin_inflammation1.17109751
67MP0003172_abnormal_lysosome_physiology1.16713566
68MP0003300_gastrointestinal_ulcer1.15285253
69MP0003303_peritoneal_inflammation1.14375559
70MP0009053_abnormal_anal_canal1.13207335
71MP0000428_abnormal_craniofacial_morphol1.12332443
72MP0001346_abnormal_lacrimal_gland1.11916878
73MP0001661_extended_life_span1.11712156
74MP0000313_abnormal_cell_death1.10417361
75MP0010234_abnormal_vibrissa_follicle1.10099034
76MP0003566_abnormal_cell_adhesion1.08670001
77MP0006292_abnormal_olfactory_placode1.07627596
78MP0000858_altered_metastatic_potential1.05598340
79MP0003942_abnormal_urinary_system1.04654565
80MP0008932_abnormal_embryonic_tissue1.04435751
81MP0009278_abnormal_bone_marrow1.04410360
82MP0002398_abnormal_bone_marrow1.03395076
83MP0005621_abnormal_cell_physiology1.02339805
84MP0009840_abnormal_foam_cell1.01214695
85MP0000733_abnormal_muscle_development1.00239171
86MP0004811_abnormal_neuron_physiology0.99791954
87MP0010630_abnormal_cardiac_muscle0.99407827
88MP0008770_decreased_survivor_rate0.98532263
89MP0005257_abnormal_intraocular_pressure0.98207612
90MP0009384_cardiac_valve_regurgitation0.96194498
91MP0008569_lethality_at_weaning0.94978963
92MP0005384_cellular_phenotype0.94644430
93MP0002089_abnormal_postnatal_growth/wei0.92916216
94MP0003861_abnormal_nervous_system0.91950973
95MP0002063_abnormal_learning/memory/cond0.91662096
96MP0002019_abnormal_tumor_incidence0.90031726
97MP0001545_abnormal_hematopoietic_system0.89146407
98MP0005397_hematopoietic_system_phenotyp0.89146407
99MP0000371_diluted_coat_color0.87614170
100MP0004264_abnormal_extraembryonic_tissu0.87111048
101MP0002254_reproductive_system_inflammat0.86507124
102MP0000490_abnormal_crypts_of0.85983203
103MP0002722_abnormal_immune_system0.85857716
104MP0002822_catalepsy0.85213064
105MP0005394_taste/olfaction_phenotype0.85031416
106MP0005499_abnormal_olfactory_system0.85031416
107MP0009046_muscle_twitch0.84965510
108MP0009931_abnormal_skin_appearance0.84869404
109MP0002909_abnormal_adrenal_gland0.84681390
110MP0002060_abnormal_skin_morphology0.84035423
111MP0003115_abnormal_respiratory_system0.83514263
112MP0000013_abnormal_adipose_tissue0.82674993
113MP0002092_abnormal_eye_morphology0.80757410
114MP0001293_anophthalmia0.80575622
115MP0003786_premature_aging0.79836990
116MP0009780_abnormal_chondrocyte_physiolo0.79154880
117MP0002116_abnormal_craniofacial_bone0.78819454
118MP0001216_abnormal_epidermal_layer0.77719892
119MP0003122_maternal_imprinting0.77318271
120MP0002925_abnormal_cardiovascular_devel0.76633248
121MP0000579_abnormal_nail_morphology0.75884079
122MP0003866_abnormal_defecation0.75375067
123MP0003567_abnormal_fetal_cardiomyocyte0.74620575
124MP0000467_abnormal_esophagus_morphology0.74527409
125MP0000759_abnormal_skeletal_muscle0.74148974
126MP0002111_abnormal_tail_morphology0.74104341
127MP0002269_muscular_atrophy0.74027307
128MP0000681_abnormal_thyroid_gland0.73831766
129MP0000685_abnormal_immune_system0.73642804
130MP0002152_abnormal_brain_morphology0.73564527
131MP0003045_fibrosis0.73478735
132MP0000566_synostosis0.72801344
133MP0002932_abnormal_joint_morphology0.72341450
134MP0000266_abnormal_heart_morphology0.70596590
135MP0000689_abnormal_spleen_morphology0.70259933
136MP0004510_myositis0.70112258
137MP0002877_abnormal_melanocyte_morpholog0.69174194
138MP0005375_adipose_tissue_phenotype0.68710104
139MP0010768_mortality/aging0.65648880
140MP0010769_abnormal_survival0.65396446
141MP0003935_abnormal_craniofacial_develop0.64874451
142MP0004858_abnormal_nervous_system0.64340054
143MP0002210_abnormal_sex_determination0.63981096
144MP0000358_abnormal_cell_content/0.63356961

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.52916970
2Abnormality of the astrocytes (HP:0100707)3.70321415
3Astrocytoma (HP:0009592)3.70321415
4Ulnar bowing (HP:0003031)3.46517227
5Hyperacusis (HP:0010780)3.44565679
6Obstructive sleep apnea (HP:0002870)3.28486785
7Abnormality of the lower motor neuron (HP:0002366)3.25344351
8Volvulus (HP:0002580)3.08471129
9Glioma (HP:0009733)3.00104195
10Abnormality of the aortic arch (HP:0012303)2.96600724
11Broad distal phalanx of finger (HP:0009836)2.92525280
12Broad face (HP:0000283)2.90704720
13Abnormality of the fingertips (HP:0001211)2.87116137
14Neoplasm of the heart (HP:0100544)2.86214963
15Medulloblastoma (HP:0002885)2.79339040
16Thin bony cortex (HP:0002753)2.77457665
17Long palpebral fissure (HP:0000637)2.72953187
18Increased nuchal translucency (HP:0010880)2.64691630
19Pointed chin (HP:0000307)2.58899857
20Neoplasm of striated muscle (HP:0009728)2.57369526
21Heterotopia (HP:0002282)2.55644043
22Urethral obstruction (HP:0000796)2.55478052
23Disproportionate tall stature (HP:0001519)2.55105176
24Elfin facies (HP:0004428)2.54101391
25Prominent nose (HP:0000448)2.52152275
26Abnormality of the labia minora (HP:0012880)2.49917478
27Basal cell carcinoma (HP:0002671)2.49104133
28Neoplasm of the oral cavity (HP:0100649)2.48085602
29Anal stenosis (HP:0002025)2.44630200
30Stridor (HP:0010307)2.43537349
31Atelectasis (HP:0100750)2.40538796
32Hand muscle atrophy (HP:0009130)2.39149389
33Achilles tendon contracture (HP:0001771)2.39006429
34Impaired smooth pursuit (HP:0007772)2.36851304
35Dysmetric saccades (HP:0000641)2.36748472
36Increased connective tissue (HP:0009025)2.35923851
37Insomnia (HP:0100785)2.34666532
38Distal lower limb amyotrophy (HP:0008944)2.34637812
39Fragile skin (HP:0001030)2.34245372
40Renovascular hypertension (HP:0100817)2.33717820
41Obsessive-compulsive behavior (HP:0000722)2.33176535
42Truncus arteriosus (HP:0001660)2.33125607
43Progressive muscle weakness (HP:0003323)2.33108290
44Abnormality of the thoracic spine (HP:0100711)2.32847694
45Long eyelashes (HP:0000527)2.32697626
46Cerebral aneurysm (HP:0004944)2.32529335
47Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.31348472
48Short 4th metacarpal (HP:0010044)2.31348472
49Urinary urgency (HP:0000012)2.30728064
50Distal upper limb amyotrophy (HP:0007149)2.29081574
51Upper limb amyotrophy (HP:0009129)2.29081574
52Spinal muscular atrophy (HP:0007269)2.27814282
53Patellar dislocation (HP:0002999)2.24568729
54Abnormality of the distal phalanx of the thumb (HP:0009617)2.18183767
55Turricephaly (HP:0000262)2.15311223
56Impaired vibration sensation in the lower limbs (HP:0002166)2.14488254
57Proximal placement of thumb (HP:0009623)2.13359631
58Abnormality of the Achilles tendon (HP:0005109)2.11873580
59Abnormality of ocular smooth pursuit (HP:0000617)2.11164937
60Renal duplication (HP:0000075)2.11042170
61Flat acetabular roof (HP:0003180)2.10879485
62Deviation of the thumb (HP:0009603)2.10720083
63Mitral regurgitation (HP:0001653)2.10494600
64Progressive external ophthalmoplegia (HP:0000590)2.10442466
65Bowed forearm bones (HP:0003956)2.08089115
66Bowing of the arm (HP:0006488)2.08089115
67Macroorchidism (HP:0000053)2.07098547
68Metaphyseal cupping (HP:0003021)2.06360541
69Resting tremor (HP:0002322)2.06234299
70Abnormal number of incisors (HP:0011064)2.04162094
71Overriding aorta (HP:0002623)2.02907259
72Urinary bladder sphincter dysfunction (HP:0002839)2.02769393
73Abnormality of the radial head (HP:0003995)2.01176614
74Hemiplegia (HP:0002301)1.99854417
75High anterior hairline (HP:0009890)1.96858991
76Skin tags (HP:0010609)1.96846533
77Cafe-au-lait spot (HP:0000957)1.95984542
78Broad palm (HP:0001169)1.95414635
79Short nail (HP:0001799)1.93822495
80Neoplasm of the adrenal cortex (HP:0100641)1.93174272
81Abnormality of the distal phalanges of the toes (HP:0010182)1.91992976
82Hyperthyroidism (HP:0000836)1.90989177
83Nasal polyposis (HP:0100582)1.90953255
84Attention deficit hyperactivity disorder (HP:0007018)1.90111170
85Self-mutilation (HP:0000742)1.89461260
86Bowel incontinence (HP:0002607)1.89190237
87Abnormality of the columella (HP:0009929)1.88185810
88Annular pancreas (HP:0001734)1.87918061
89Colitis (HP:0002583)1.87576521
90Squamous cell carcinoma (HP:0002860)1.86295676
91Sandal gap (HP:0001852)1.84923843
92Selective tooth agenesis (HP:0001592)1.84698204
93Bowel diverticulosis (HP:0005222)1.84481951
94Persistence of primary teeth (HP:0006335)1.84104568
95Thoracic kyphosis (HP:0002942)1.83809086
96Rhabdomyosarcoma (HP:0002859)1.82939068
97Flared metaphyses (HP:0003015)1.82840822
98Ankle clonus (HP:0011448)1.82399164
99Biconcave vertebral bodies (HP:0004586)1.81992651
100Hypopigmentation of the fundus (HP:0007894)1.81883298
101Vertebral arch anomaly (HP:0008438)1.81294976
102Adenoma sebaceum (HP:0009720)1.80414192
103Angiofibromas (HP:0010615)1.80414192
104Narrow palate (HP:0000189)1.79847202
105Precocious puberty (HP:0000826)1.79756554
106Ragged-red muscle fibers (HP:0003200)1.78955607
107Lymphangioma (HP:0100764)1.78480298
108Spina bifida occulta (HP:0003298)1.77711112
109Abnormal large intestine physiology (HP:0012700)1.77630543
110Premature skin wrinkling (HP:0100678)1.76631499
111Reticulocytosis (HP:0001923)1.76551245
112Amaurosis fugax (HP:0100576)1.76070859
113Syringomyelia (HP:0003396)1.75294832
114Spinal cord lesions (HP:0100561)1.75294832
115Hypertensive crisis (HP:0100735)1.74741972
116Abnormal vertebral ossification (HP:0100569)1.73223374
117Thin ribs (HP:0000883)1.72146159
118Genetic anticipation (HP:0003743)1.72075337
119Broad thumb (HP:0011304)1.71826297
120Hypoparathyroidism (HP:0000829)1.70844618
121Truncal obesity (HP:0001956)1.70643595
122Trismus (HP:0000211)1.70498943
123Ankyloglossia (HP:0010296)1.70335587
124Trigonocephaly (HP:0000243)1.70210557
125Pelvic girdle muscle weakness (HP:0003749)1.70116402
126Visual hallucinations (HP:0002367)1.69944224
127Supernumerary ribs (HP:0005815)1.69660780
128Seborrheic dermatitis (HP:0001051)1.69439109
129Shallow orbits (HP:0000586)1.69051292
130Abnormality of the diencephalon (HP:0010662)1.68113618
131Aneurysm (HP:0002617)1.68078359
132Microvesicular hepatic steatosis (HP:0001414)1.67922906
133Skull defect (HP:0001362)1.67898043
134Abnormality of the phalanges of the hallux (HP:0010057)1.67852700
135Abnormality of the nasal mucosa (HP:0000433)1.67636968
136Missing ribs (HP:0000921)1.67175393
137Spastic gait (HP:0002064)1.67050581
138Difficulty climbing stairs (HP:0003551)1.65626794
139Pseudobulbar signs (HP:0002200)1.65590656
140Chromsome breakage (HP:0040012)1.64511424
141Hemorrhage of the eye (HP:0011885)1.64143890
142Abnormality of the humeroradial joint (HP:0100744)1.62937057
143Lower limb amyotrophy (HP:0007210)1.62925735
144Emphysema (HP:0002097)1.62793178
145Arnold-Chiari malformation (HP:0002308)1.62208326
146Germ cell neoplasia (HP:0100728)1.62146442
147Sacral dimple (HP:0000960)1.61827945
148Bronchomalacia (HP:0002780)1.61686857
149Malignant gastrointestinal tract tumors (HP:0006749)1.61608329
150Gastrointestinal carcinoma (HP:0002672)1.61608329
151Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.61242716
152Impulsivity (HP:0100710)1.61182587
153Increased density of long bones (HP:0006392)1.61009639
154Broad phalanges of the hand (HP:0009768)1.60833835
155Protrusio acetabuli (HP:0003179)1.60614192
156Smooth philtrum (HP:0000319)1.60416657
15711 pairs of ribs (HP:0000878)1.58692477
158Preauricular skin tag (HP:0000384)1.58578191
159Facial hemangioma (HP:0000329)1.58529969
160Cervical subluxation (HP:0003308)1.58151747
161J-shaped sella turcica (HP:0002680)1.57828430
162High pitched voice (HP:0001620)1.57574188
163Genu recurvatum (HP:0002816)1.57277920
164Sparse lateral eyebrow (HP:0005338)1.56806419
165Atrophic scars (HP:0001075)1.56512979
166Malignant neoplasm of the central nervous system (HP:0100836)1.56255662
167Deep palmar crease (HP:0006191)1.56188553
168Abnormality of the carotid arteries (HP:0005344)1.55972398
169Focal seizures (HP:0007359)1.55785358
170Dislocated radial head (HP:0003083)1.54950130
171Chromosomal breakage induced by crosslinking agents (HP:0003221)1.54168411
172Birth length less than 3rd percentile (HP:0003561)1.53472085
173Supernumerary bones of the axial skeleton (HP:0009144)1.53373600
174Aplasia/Hypoplasia of the sternum (HP:0006714)1.53324898
175Fibroma (HP:0010614)1.52812439

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG14.44158542
2CDK124.05838052
3EEF2K3.08782180
4CDC72.78971630
5PRPF4B2.78806427
6RIPK12.77182440
7TRIB32.52383209
8PKN22.47497249
9SIK22.39553547
10NEK22.36735930
11TAOK22.34274639
12IRAK32.31135886
13ALK2.23674342
14MAP3K102.18956189
15BRD42.05360133
16TSSK62.02942936
17INSRR1.97351171
18ERN11.96442503
19NEK11.87274745
20NME21.84151288
21MAP3K91.71761861
22PRKD31.64963126
23MAP4K11.58310202
24PNCK1.56229922
25MAP3K71.52044444
26SCYL21.50975368
27CAMK1G1.50473212
28CDK41.48994911
29TAOK11.47202505
30ICK1.44478376
31NTRK31.44357181
32MTOR1.44304616
33FGFR41.39881995
34MAP2K31.35567398
35CHEK11.34168727
36STK381.32360891
37ATR1.30658905
38TYRO31.29871956
39WEE11.26919331
40CAMK1D1.25232825
41TTK1.22290200
42MARK21.20189687
43MST1R1.17911898
44MAP3K111.09200299
45NME11.03588732
46PASK1.02514246
47MAP3K41.01061144
48CDC42BPA1.00310913
49CDK21.00256006
50DAPK21.00152717
51IRAK20.98800580
52TTN0.96330085
53RPS6KB20.96231442
54DAPK10.95899328
55CAMKK10.93805556
56HIPK20.89510976
57CDK70.88283992
58IRAK40.87137777
59RIPK40.86075963
60MAPK110.85543125
61ATM0.84800772
62PAK60.82778321
63CDK60.82674760
64GRK60.82656427
65PLK10.82481129
66CSNK1E0.79593294
67MAP2K60.78506057
68CHEK20.78015025
69PTK60.77389816
70KSR20.76037527
71RPS6KL10.75191310
72RPS6KC10.75191310
73BRSK10.74477576
74PRKCH0.73300967
75PRKDC0.72781332
76CAMK40.72003209
77ZAP700.71498357
78PDGFRA0.70824526
79CDK90.70783350
80SIK10.70562627
81MAP3K80.70522467
82SGK30.70498816
83MKNK20.70408067
84PTK20.70058053
85PDPK10.67582362
86CDK10.67550639
87MAPK150.65846489
88NTRK20.64960296
89STK100.63749868
90AURKA0.63341943
91PRKCI0.62982953
92MAP3K10.62413124
93PRKD20.62053617
94LATS20.61089882
95* MAPK140.60787995
96MAPK100.59954980
97KSR10.59602896
98SRPK10.59491613
99* GSK3B0.58328776
100CSNK1D0.57988768
101AURKB0.57603012
102PAK20.57147033
103MAP3K140.56912778
104EPHA20.56591777
105MAP2K20.56467938
106RPS6KA60.55079376
107MAP3K60.54967234
108MAP3K130.54074582
109BMX0.53987436
110TBK10.53836100
111JAK30.53772700
112SIK30.53496131
113RPS6KA20.53219155
114STK110.53199170
115FGFR10.52446230
116CAMK10.51951438
117MAPK80.51828336
118AKT30.51315110
119EPHB10.50046342
120PIM20.48586845
121PLK30.48175796
122FES0.47871570
123RPS6KA10.47777221
124BUB10.46403196
125PIM10.44863748
126RPS6KA30.44554806
127MARK30.43600832
128EPHA40.43444275
129TNK20.43186023
130CHUK0.42781834
131ARAF0.41935283
132RAF10.41671772
133BRAF0.41619771
134MELK0.41373975
135MAPK10.40313694
136RPS6KA40.38890949
137HCK0.38634749
138PAK40.38556856
139TYK20.38515963
140MAPK120.38123179
141MAP3K30.37634319
142PDK10.35038817
143RET0.33655794
144BTK0.33610024
145CDK80.32304842
146AKT20.32290363
147LRRK20.31363216
148MET0.30322284
149AKT10.29777406

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.27769871
2RNA transport_Homo sapiens_hsa030132.12102977
3Other glycan degradation_Homo sapiens_hsa005112.07514521
4Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.06210017
5mRNA surveillance pathway_Homo sapiens_hsa030152.02361685
6DNA replication_Homo sapiens_hsa030301.95865417
7Spliceosome_Homo sapiens_hsa030401.88900588
8One carbon pool by folate_Homo sapiens_hsa006701.85368799
9Bladder cancer_Homo sapiens_hsa052191.85233812
10Mismatch repair_Homo sapiens_hsa034301.81349102
11mTOR signaling pathway_Homo sapiens_hsa041501.80338251
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.57997315
13Sulfur relay system_Homo sapiens_hsa041221.51112532
14Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.50856246
15Cell cycle_Homo sapiens_hsa041101.48687657
16Lysine degradation_Homo sapiens_hsa003101.46345134
17Long-term potentiation_Homo sapiens_hsa047201.44714035
18Type II diabetes mellitus_Homo sapiens_hsa049301.42744794
19Olfactory transduction_Homo sapiens_hsa047401.42536047
20Thyroid hormone signaling pathway_Homo sapiens_hsa049191.36206623
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.31289159
22Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.31057373
23Base excision repair_Homo sapiens_hsa034101.30053208
24Oocyte meiosis_Homo sapiens_hsa041141.28866597
25Fructose and mannose metabolism_Homo sapiens_hsa000511.27601049
26Renal cell carcinoma_Homo sapiens_hsa052111.20507685
27Synaptic vesicle cycle_Homo sapiens_hsa047211.19473205
28Phosphatidylinositol signaling system_Homo sapiens_hsa040701.19304596
29Chronic myeloid leukemia_Homo sapiens_hsa052201.17688643
30Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.15355055
31Amphetamine addiction_Homo sapiens_hsa050311.14272090
32Insulin secretion_Homo sapiens_hsa049111.14129395
33Pentose phosphate pathway_Homo sapiens_hsa000301.13302497
34Apoptosis_Homo sapiens_hsa042101.08240477
35Toll-like receptor signaling pathway_Homo sapiens_hsa046201.07494493
36Neurotrophin signaling pathway_Homo sapiens_hsa047221.07332957
37Estrogen signaling pathway_Homo sapiens_hsa049151.07215522
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.06975005
39Central carbon metabolism in cancer_Homo sapiens_hsa052301.06914221
40Longevity regulating pathway - mammal_Homo sapiens_hsa042111.06776685
41AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.03926646
42Hepatitis C_Homo sapiens_hsa051601.03687081
43Non-small cell lung cancer_Homo sapiens_hsa052231.02856797
44Fanconi anemia pathway_Homo sapiens_hsa034601.02480206
45Colorectal cancer_Homo sapiens_hsa052101.00619089
46Choline metabolism in cancer_Homo sapiens_hsa052311.00464500
47Glioma_Homo sapiens_hsa052141.00206089
48Cyanoamino acid metabolism_Homo sapiens_hsa004600.99099471
49Notch signaling pathway_Homo sapiens_hsa043300.98575869
50T cell receptor signaling pathway_Homo sapiens_hsa046600.97621003
51Glycosaminoglycan degradation_Homo sapiens_hsa005310.97327464
52Endometrial cancer_Homo sapiens_hsa052130.95400813
53Viral carcinogenesis_Homo sapiens_hsa052030.95392251
54Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.94237147
55Non-homologous end-joining_Homo sapiens_hsa034500.94038124
56Prion diseases_Homo sapiens_hsa050200.94011915
57Influenza A_Homo sapiens_hsa051640.93434368
58MicroRNAs in cancer_Homo sapiens_hsa052060.92851936
59Glucagon signaling pathway_Homo sapiens_hsa049220.92312498
60TNF signaling pathway_Homo sapiens_hsa046680.91153876
61Osteoclast differentiation_Homo sapiens_hsa043800.90825936
62HTLV-I infection_Homo sapiens_hsa051660.90638528
63Dopaminergic synapse_Homo sapiens_hsa047280.90388811
64B cell receptor signaling pathway_Homo sapiens_hsa046620.90212063
65Nicotine addiction_Homo sapiens_hsa050330.90119416
66Acute myeloid leukemia_Homo sapiens_hsa052210.89859315
67Primary immunodeficiency_Homo sapiens_hsa053400.89777427
68Circadian entrainment_Homo sapiens_hsa047130.89248763
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87052509
70NF-kappa B signaling pathway_Homo sapiens_hsa040640.85529905
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.84596044
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.83960943
73Toxoplasmosis_Homo sapiens_hsa051450.83523775
74Epstein-Barr virus infection_Homo sapiens_hsa051690.83240645
75Insulin resistance_Homo sapiens_hsa049310.82058561
76RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.81293270
77Nucleotide excision repair_Homo sapiens_hsa034200.80721588
78RNA degradation_Homo sapiens_hsa030180.79529529
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.78829922
80VEGF signaling pathway_Homo sapiens_hsa043700.78051934
81p53 signaling pathway_Homo sapiens_hsa041150.77422852
82Cholinergic synapse_Homo sapiens_hsa047250.76559740
83Oxytocin signaling pathway_Homo sapiens_hsa049210.76344985
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76103127
85HIF-1 signaling pathway_Homo sapiens_hsa040660.75780179
86Insulin signaling pathway_Homo sapiens_hsa049100.75288222
87GnRH signaling pathway_Homo sapiens_hsa049120.75275932
88Galactose metabolism_Homo sapiens_hsa000520.74728717
89Adherens junction_Homo sapiens_hsa045200.74386575
90MAPK signaling pathway_Homo sapiens_hsa040100.73216007
91Glutamatergic synapse_Homo sapiens_hsa047240.73205014
92ErbB signaling pathway_Homo sapiens_hsa040120.72345572
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70745012
94Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.70295748
95Focal adhesion_Homo sapiens_hsa045100.70264882
96Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.70254700
97Prostate cancer_Homo sapiens_hsa052150.70145580
98cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69550535
99Morphine addiction_Homo sapiens_hsa050320.69223625
100Inositol phosphate metabolism_Homo sapiens_hsa005620.69023544
101Homologous recombination_Homo sapiens_hsa034400.68397800
102Prolactin signaling pathway_Homo sapiens_hsa049170.68368454
103Herpes simplex infection_Homo sapiens_hsa051680.67958986
104cAMP signaling pathway_Homo sapiens_hsa040240.65136184
105Small cell lung cancer_Homo sapiens_hsa052220.64850146
106Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64157344
107AMPK signaling pathway_Homo sapiens_hsa041520.64002454
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63934304
109Biosynthesis of amino acids_Homo sapiens_hsa012300.63480426
110Measles_Homo sapiens_hsa051620.63372892
111Salivary secretion_Homo sapiens_hsa049700.63304919
112Pancreatic cancer_Homo sapiens_hsa052120.62682624
113Thyroid cancer_Homo sapiens_hsa052160.62425901
114Leukocyte transendothelial migration_Homo sapiens_hsa046700.61977652
115Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.61725557
116Dorso-ventral axis formation_Homo sapiens_hsa043200.60528651
117Proteoglycans in cancer_Homo sapiens_hsa052050.60333085
118Cocaine addiction_Homo sapiens_hsa050300.59678876
119Gastric acid secretion_Homo sapiens_hsa049710.59614709
120Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.59300326
121Hepatitis B_Homo sapiens_hsa051610.58624228
122Gap junction_Homo sapiens_hsa045400.58331481
123Phospholipase D signaling pathway_Homo sapiens_hsa040720.58255604
124Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57896034
125Sphingolipid signaling pathway_Homo sapiens_hsa040710.57322519
126Thyroid hormone synthesis_Homo sapiens_hsa049180.57314533
127Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57289934
128Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.57043389
129Basal cell carcinoma_Homo sapiens_hsa052170.56696946
130Endocytosis_Homo sapiens_hsa041440.56301551
131Shigellosis_Homo sapiens_hsa051310.55879325
132Wnt signaling pathway_Homo sapiens_hsa043100.55710072
133GABAergic synapse_Homo sapiens_hsa047270.54875506
134Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54192609
135FoxO signaling pathway_Homo sapiens_hsa040680.53488870
136Pathways in cancer_Homo sapiens_hsa052000.52337167
137Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48052623
138Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.47765985
139Rap1 signaling pathway_Homo sapiens_hsa040150.46158400
140Leishmaniasis_Homo sapiens_hsa051400.43741222

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