ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	serotonin receptor signaling pathway (GO:0007210)	9.05382071
2	positive regulation of osteoblast proliferation (GO:0033690)	9.03760434
3	angiogenesis involved in wound healing (GO:0060055)	8.34701592
4	negative regulation of interleukin-8 production (GO:0032717)	8.24502397
5	positive regulation of hair follicle development (GO:0051798)	8.19403473
6	positive regulation of hair cycle (GO:0042635)	8.19403473
7	regulation of appetite (GO:0032098)	7.55233548
8	interferon-gamma production (GO:0032609)	7.13208479
9	negative regulation of calcium ion transport into cytosol (GO:0010523)	7.06307631
10	activated T cell proliferation (GO:0050798)	6.67633509
11	regulation of Cdc42 GTPase activity (GO:0043088)	6.64148610
12	negative regulation of circadian rhythm (GO:0042754)	6.50862554
13	glycerophospholipid catabolic process (GO:0046475)	5.80114588
14	glycoprotein catabolic process (GO:0006516)	5.80012075
15	protein K48-linked deubiquitination (GO:0071108)	5.68591813
16	hematopoietic stem cell proliferation (GO:0071425)	5.64453127
17	protein K63-linked deubiquitination (GO:0070536)	5.57138727
18	regulation of hair follicle development (GO:0051797)	5.21209705
19	lymphangiogenesis (GO:0001946)	5.15673517
20	granulocyte differentiation (GO:0030851)	5.03558264
21	disruption of cells of other organism (GO:0044364)	5.03155549
22	killing of cells of other organism (GO:0031640)	5.03155549
23	mucosal immune response (GO:0002385)	5.01978421
24	thyroid hormone metabolic process (GO:0042403)	5.01608129
25	sulfation (GO:0051923)	4.98540855
26	cysteine metabolic process (GO:0006534)	4.93086852
27	carnitine transmembrane transport (GO:1902603)	4.81102731
28	omega-hydroxylase P450 pathway (GO:0097267)	4.72593512
29	organ or tissue specific immune response (GO:0002251)	4.59586397
30	homocysteine metabolic process (GO:0050667)	4.53633605
31	filopodium assembly (GO:0046847)	4.52692076
32	phospholipid translocation (GO:0045332)	4.43519191
33	lipid translocation (GO:0034204)	4.43519191
34	carnitine transport (GO:0015879)	4.37131272
35	amino-acid betaine transport (GO:0015838)	4.37131272
36	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	4.35767342
37	carnitine metabolic process (GO:0009437)	4.20949745
38	positive regulation of cAMP-mediated signaling (GO:0043950)	4.18962861
39	negative regulation of metanephros development (GO:0072217)	4.05710290
40	defense response to fungus (GO:0050832)	4.02230887
41	low-density lipoprotein particle remodeling (GO:0034374)	3.96129998
42	paraxial mesoderm development (GO:0048339)	3.94491974
43	organic cation transport (GO:0015695)	3.91440662
44	regulation of B cell receptor signaling pathway (GO:0050855)	3.86778558
45	heparan sulfate proteoglycan metabolic process (GO:0030201)	3.85854333
46	regulation of integrin-mediated signaling pathway (GO:2001044)	3.84234520
47	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.82257892
48	regulation of osteoblast proliferation (GO:0033688)	3.78835630
49	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	3.78422322
50	androgen biosynthetic process (GO:0006702)	3.75132971
51	negative regulation of hormone biosynthetic process (GO:0032353)	3.74793410
52	axon ensheathment in central nervous system (GO:0032291)	3.69771968
53	central nervous system myelination (GO:0022010)	3.69771968
54	synaptic vesicle docking involved in exocytosis (GO:0016081)	3.69653874
55	regulation of hair cycle (GO:0042634)	3.68240761
56	positive regulation of blood coagulation (GO:0030194)	3.66965414
57	positive regulation of hemostasis (GO:1900048)	3.66965414
58	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.66678159
59	positive regulation of epidermis development (GO:0045684)	3.62812910
60	startle response (GO:0001964)	3.55588682
61	righting reflex (GO:0060013)	3.52926914
62	platelet formation (GO:0030220)	3.52219484
63	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	3.50940759
64	protein sumoylation (GO:0016925)	3.50598526
65	flavonoid metabolic process (GO:0009812)	3.45446270
66	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.45001240
67	regulation of steroid hormone biosynthetic process (GO:0090030)	3.44523201
68	positive regulation of coagulation (GO:0050820)	3.37209438
69	negative regulation of hormone metabolic process (GO:0032351)	3.32565115
70	quaternary ammonium group transport (GO:0015697)	3.31974262
71	positive regulation of inositol phosphate biosynthetic process (GO:0060732)	3.31422987
72	tryptophan catabolic process (GO:0006569)	3.31261875
73	indole-containing compound catabolic process (GO:0042436)	3.31261875
74	indolalkylamine catabolic process (GO:0046218)	3.31261875
75	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	3.25934451
76	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	3.25934451
77	cell killing (GO:0001906)	3.24059418
78	superoxide anion generation (GO:0042554)	3.23209503
79	regulation of sarcomere organization (GO:0060297)	3.18983268
80	sex differentiation (GO:0007548)	3.17293788
81	negative regulation by host of viral transcription (GO:0043922)	3.16030797
82	negative regulation of mast cell activation (GO:0033004)	3.14475630
83	amino-acid betaine metabolic process (GO:0006577)	3.14419261
84	maturation of 5.8S rRNA (GO:0000460)	3.14064533
85	retinal cone cell development (GO:0046549)	3.13550429
86	regulation of membrane lipid distribution (GO:0097035)	3.12517022
87	DNA double-strand break processing (GO:0000729)	3.10800820
88	positive regulation of vasculogenesis (GO:2001214)	3.08051582
89	skin development (GO:0043588)	3.07487683
90	reflex (GO:0060004)	3.07145967
91	rRNA catabolic process (GO:0016075)	3.07097034
92	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	3.04384099
93	spindle assembly involved in mitosis (GO:0090307)	3.04089250
94	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.99637379
95	regulation of transmission of nerve impulse (GO:0051969)	2.95299992
96	establishment of protein localization to Golgi (GO:0072600)	2.94861318
97	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	2.91699368
98	protein-cofactor linkage (GO:0018065)	2.90220014
99	endothelial cell proliferation (GO:0001935)	2.85990160
100	protein K11-linked deubiquitination (GO:0035871)	14.8214516

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	6.29608208
2	IKZF1_21737484_ChIP-ChIP_HCT116_Human	5.05291210
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	4.33283315
4	SMAD_19615063_ChIP-ChIP_OVARY_Human	3.62555180
5	ESR1_20079471_ChIP-ChIP_T-47D_Human	3.14174260
6	TAF15_26573619_Chip-Seq_HEK293_Human	2.94552260
7	DROSHA_22980978_ChIP-Seq_HELA_Human	2.66996090
8	TP53_16413492_ChIP-PET_HCT116_Human	2.49670610
9	EZH2_22144423_ChIP-Seq_EOC_Human	2.46581082
10	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.46259400
11	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.35100689
12	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.29417649
13	AR_21572438_ChIP-Seq_LNCaP_Human	2.22987977
14	AR_25329375_ChIP-Seq_VCAP_Human	2.08973586
15	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.84213088
16	ER_23166858_ChIP-Seq_MCF-7_Human	1.80161600
17	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.79774863
18	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.70590285
19	SMAD4_21799915_ChIP-Seq_A2780_Human	1.69511179
20	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.67814587
21	IGF1R_20145208_ChIP-Seq_DFB_Human	1.67112581
22	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.62663081
23	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.60546207
24	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.57458067
25	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.53452712
26	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.51776477
27	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.49050853
28	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.48707174
29	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.45408880
30	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.42330951
31	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.42319846
32	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.42236670
33	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.42160396
34	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.41236675
35	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.40833395
36	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.40181553
37	STAT3_23295773_ChIP-Seq_U87_Human	1.39784093
38	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.37221481
39	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.36260081
40	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.35847581
41	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.35718618
42	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.32427950
43	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.32344857
44	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.29095298
45	TP53_18474530_ChIP-ChIP_U2OS_Human	1.27449346
46	LUZP1_20508642_ChIP-Seq_ESCs_Mouse	1.27214166
47	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.27059123
48	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.26949732
49	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.26909550
50	TCF4_23295773_ChIP-Seq_U87_Human	1.26136303
51	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.25899243
52	P300_19829295_ChIP-Seq_ESCs_Human	1.25194145
53	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.24518764
54	EWS_26573619_Chip-Seq_HEK293_Human	1.24374290
55	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	1.23684131
56	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.23455900
57	TP53_22573176_ChIP-Seq_HFKS_Human	1.22382684
58	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.20394737
59	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.18869393
60	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.17071504
61	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.15963061
62	CBP_20019798_ChIP-Seq_JUKART_Human	1.15963061
63	SPI1_23127762_ChIP-Seq_K562_Human	1.13385360
64	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.12529971
65	JUN_21703547_ChIP-Seq_K562_Human	1.11673655
66	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.11156231
67	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.11001098
68	CDX2_22108803_ChIP-Seq_LS180_Human	1.10871305
69	SOX3_22085726_ChIP-Seq_MUSCLE_Mouse	1.09527853
70	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.09352329
71	PHF8_20622853_ChIP-Seq_HELA_Human	1.07182434
72	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	1.06513702
73	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.05701896
74	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.05394649
75	AR_19668381_ChIP-Seq_PC3_Human	1.01879029
76	RUNX2_22187159_ChIP-Seq_PCA_Human	1.01711471
77	TBL1_22424771_ChIP-Seq_293T_Human	1.01112233
78	REST_21632747_ChIP-Seq_MESCs_Mouse	1.00008741
79	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.98146606
80	BCAT_22108803_ChIP-Seq_LS180_Human	0.97019539
81	CJUN_26792858_Chip-Seq_BT549_Human	0.95990241
82	ELK4_26923725_Chip-Seq_MESODERM_Mouse	0.95762088
83	GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse	0.95647828
84	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.95349971
85	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.95233077
86	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.94364404
87	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.93133947
88	TCF4_22108803_ChIP-Seq_LS180_Human	0.92804118
89	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.91833135
90	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.90865016
91	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.87665014
92	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.86288572
93	STAT1_20625510_ChIP-Seq_HELA_Human	0.84854136
94	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.84529597
95	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.84529597
96	PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	0.84524417
97	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.84397174
98	P53_22387025_ChIP-Seq_ESCs_Mouse	0.84259507
99	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.84218737
100	RBPJ_21746931_ChIP-Seq_IB4_Human	0.84205664

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003183_abnormal_peptide_metabolism	7.89770188
2	MP0005310_abnormal_salivary_gland	4.49488977
3	MP0002138_abnormal_hepatobiliary_system	4.31817434
4	MP0005670_abnormal_white_adipose	4.12619512
5	MP0002254_reproductive_system_inflammat	4.06729218
6	MP0008875_abnormal_xenobiotic_pharmacok	3.80708013
7	MP0002139_abnormal_hepatobiliary_system	3.62863557
8	MP0003806_abnormal_nucleotide_metabolis	3.18330442
9	MP0001984_abnormal_olfaction	3.13108644
10	MP0003283_abnormal_digestive_organ	2.79347068
11	MP0005464_abnormal_platelet_physiology	2.69447125
12	MP0001348_abnormal_lacrimal_gland	2.66365252
13	MP0004043_abnormal_pH_regulation	2.44329619
14	MP0001919_abnormal_reproductive_system	2.18953590
15	MP0003724_increased_susceptibility_to	2.06363447
16	MP0001879_abnormal_lymphatic_vessel	2.05007213
17	MP0005647_abnormal_sex_gland	2.02554735
18	MP0005503_abnormal_tendon_morphology	1.99643787
19	MP0002876_abnormal_thyroid_physiology	1.89878980
20	MP0006276_abnormal_autonomic_nervous	1.81192442
21	MP0002064_seizures	1.80469942
22	MP0000230_abnormal_systemic_arterial	1.75343557
23	MP0006082_CNS_inflammation	1.69759023
24	MP0005187_abnormal_penis_morphology	1.69106063
25	MP0009046_muscle_twitch	1.68537862
26	MP0005551_abnormal_eye_electrophysiolog	1.64490279
27	MP0005389_reproductive_system_phenotype	1.60236091
28	MP0002735_abnormal_chemical_nociception	1.59846156
29	MP0005084_abnormal_gallbladder_morpholo	1.57546119
30	MP0000613_abnormal_salivary_gland	1.52462847
31	MP0009745_abnormal_behavioral_response	1.48168094
32	MP0002736_abnormal_nociception_after	1.42536240
33	MP0001873_stomach_inflammation	1.40340669
34	MP0003638_abnormal_response/metabolism_	1.40207675
35	MP0002006_tumorigenesis	1.35130201
36	MP0005167_abnormal_blood-brain_barrier	1.33011277
37	MP0002970_abnormal_white_adipose	1.32786537
38	MP0004142_abnormal_muscle_tone	1.25529314
39	MP0008569_lethality_at_weaning	1.21167783
40	MP0001968_abnormal_touch/_nociception	1.20696293
41	MP0001970_abnormal_pain_threshold	1.16732517
42	MP0001346_abnormal_lacrimal_gland	1.12588835
43	MP0006054_spinal_hemorrhage	1.11991773
44	MP0001486_abnormal_startle_reflex	1.10170955
45	MP0001905_abnormal_dopamine_level	1.10125220
46	MP0010329_abnormal_lipoprotein_level	1.07070076
47	MP0005275_abnormal_skin_tensile	1.05153306
48	MP0002928_abnormal_bile_duct	1.04684962
49	MP0002572_abnormal_emotion/affect_behav	0.99391901
50	MP0008874_decreased_physiological_sensi	0.96760957
51	MP0005164_abnormal_response_to	0.94290589
52	MP0002272_abnormal_nervous_system	0.92927585
53	MP0005377_hearing/vestibular/ear_phenot	0.91657717
54	MP0003878_abnormal_ear_physiology	0.91657717
55	MP0000639_abnormal_adrenal_gland	0.91565375
56	MP0000569_abnormal_digit_pigmentation	0.88713012
57	MP0005257_abnormal_intraocular_pressure	0.88119985
58	MP0005410_abnormal_fertilization	0.83563277
59	MP0000383_abnormal_hair_follicle	0.81490062
60	MP0001764_abnormal_homeostasis	0.80548446
61	MP0004858_abnormal_nervous_system	0.80393706
62	MP0010155_abnormal_intestine_physiology	0.80204581
63	MP0004134_abnormal_chest_morphology	0.78703252
64	MP0003279_aneurysm	0.76893623
65	MP0002734_abnormal_mechanical_nocicepti	0.75984486
66	MP0003315_abnormal_perineum_morphology	0.74406856
67	MP0002063_abnormal_learning/memory/cond	0.73957746
68	MP0001501_abnormal_sleep_pattern	0.73829809
69	MP0004085_abnormal_heartbeat	0.73142082
70	MP0002269_muscular_atrophy	0.72315174
71	MP0000685_abnormal_immune_system	0.70693862
72	MP0005253_abnormal_eye_physiology	0.69813398
73	MP0001851_eye_inflammation	0.69388936
74	MP0001986_abnormal_taste_sensitivity	0.68969810
75	MP0000249_abnormal_blood_vessel	0.68477062
76	MP0009250_abnormal_appendicular_skeleto	0.68297942
77	MP0001663_abnormal_digestive_system	0.67159953
78	MP0008961_abnormal_basal_metabolism	0.64742545
79	MP0005595_abnormal_vascular_smooth	0.64247846
80	MP0003635_abnormal_synaptic_transmissio	0.63023408
81	MP0005452_abnormal_adipose_tissue	0.62829137
82	MP0009642_abnormal_blood_homeostasis	0.62069381
83	MP0004130_abnormal_muscle_cell	0.61266111
84	MP0002971_abnormal_brown_adipose	0.60969296
85	MP0002127_abnormal_cardiovascular_syste	0.60007733
86	MP0005381_digestive/alimentary_phenotyp	0.58929686
87	MP0008872_abnormal_physiological_respon	0.57959839
88	MP0002118_abnormal_lipid_homeostasis	0.57720379
89	MP0003936_abnormal_reproductive_system	0.55236666
90	MP0010678_abnormal_skin_adnexa	0.55066277
91	MP0002733_abnormal_thermal_nociception	0.55017168
92	MP0005387_immune_system_phenotype	0.54814965
93	MP0001790_abnormal_immune_system	0.54814965
94	MP0010386_abnormal_urinary_bladder	0.54125563
95	MP0002452_abnormal_antigen_presenting	0.53881859
96	MP0005360_urolithiasis	0.50571390
97	MP0002148_abnormal_hypersensitivity_rea	0.49786084
98	MP0003195_calcinosis	0.49050173
99	MP0002229_neurodegeneration	0.47859603
100	MP0001440_abnormal_grooming_behavior	0.47478427

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital sensorineural hearing impairment (HP:0008527)	6.34890053
2	Retrobulbar optic neuritis (HP:0100654)	5.61348307
3	Optic neuritis (HP:0100653)	5.61348307
4	Lower limb hyperreflexia (HP:0002395)	5.56009195
5	Bilateral sensorineural hearing impairment (HP:0008619)	5.24832166
6	Keratoconjunctivitis (HP:0001096)	5.02568672
7	Orchitis (HP:0100796)	4.93493830
8	Poikiloderma (HP:0001029)	4.46366801
9	Decreased circulating renin level (HP:0003351)	4.28913629
10	Anomalous pulmonary venous return (HP:0010772)	4.06072080
11	Myositis (HP:0100614)	3.85118729
12	Metaphyseal dysplasia (HP:0100255)	3.69418555
13	Abnormality of the pericardium (HP:0001697)	3.64880119
14	Abnormal pancreas size (HP:0012094)	3.63403920
15	Keratoconjunctivitis sicca (HP:0001097)	3.61394144
16	Prolonged bleeding time (HP:0003010)	3.53301705
17	Abnormality of the pulmonary veins (HP:0011718)	3.52790569
18	Attenuation of retinal blood vessels (HP:0007843)	3.49381597
19	Enlarged penis (HP:0000040)	3.48947194
20	Tinnitus (HP:0000360)	3.47478179
21	Xanthomatosis (HP:0000991)	3.39536296
22	Hypoplasia of the uterus (HP:0000013)	3.37748971
23	Congenital stationary night blindness (HP:0007642)	3.29785104
24	Abolished electroretinogram (ERG) (HP:0000550)	3.26950711
25	Bony spicule pigmentary retinopathy (HP:0007737)	3.11543568
26	Hyperventilation (HP:0002883)	3.05311924
27	Abnormality of dentin (HP:0010299)	3.00609750
28	Gout (HP:0001997)	2.98171238
29	True hermaphroditism (HP:0010459)	2.94663350
30	Basal ganglia calcification (HP:0002135)	2.93534780
31	Arthropathy (HP:0003040)	2.89035258
32	Unilateral renal agenesis (HP:0000122)	2.78737519
33	Mesangial abnormality (HP:0001966)	2.70037355
34	Craniofacial hyperostosis (HP:0004493)	2.69836329
35	Male pseudohermaphroditism (HP:0000037)	2.63158775
36	Vitreoretinal degeneration (HP:0000655)	2.59748873
37	Hypoplastic ischia (HP:0003175)	2.58923524
38	Hyperglycinuria (HP:0003108)	2.57266895
39	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.52746774
40	Absent speech (HP:0001344)	2.50937117
41	Abnormality of dental color (HP:0011073)	2.49744258
42	Preaxial foot polydactyly (HP:0001841)	2.49486558
43	Delayed closure of the anterior fontanelle (HP:0001476)	2.43755100
44	Vertigo (HP:0002321)	2.41100499
45	Abnormal drinking behavior (HP:0030082)	2.36730907
46	Polydipsia (HP:0001959)	2.36730907
47	Late onset (HP:0003584)	2.34631766
48	Encephalitis (HP:0002383)	2.33429197
49	Anorexia (HP:0002039)	2.32922609
50	Absent frontal sinuses (HP:0002688)	2.32344472
51	Aplasia/hypoplasia of the uterus (HP:0008684)	2.31583074
52	Spastic tetraparesis (HP:0001285)	2.29605599
53	Cranial hyperostosis (HP:0004437)	2.24122655
54	Acne (HP:0001061)	2.23818622
55	Hypoplastic left heart (HP:0004383)	2.22984513
56	Gonadotropin excess (HP:0000837)	2.21291155
57	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.20899660
58	Pancreatic cysts (HP:0001737)	2.19466317
59	Arterial thrombosis (HP:0004420)	2.18520727
60	Ileus (HP:0002595)	2.18448898
61	Spastic paraplegia (HP:0001258)	2.17933944
62	Clumsiness (HP:0002312)	2.17920492
63	Bicornuate uterus (HP:0000813)	2.17656022
64	Delayed puberty (HP:0000823)	2.15915063
65	Hyperlipoproteinemia (HP:0010980)	2.14846346
66	Keratitis (HP:0000491)	2.14772527
67	Onion bulb formation (HP:0003383)	2.14180721
68	Hyperaldosteronism (HP:0000859)	2.13957161
69	Abnormality of the ischium (HP:0003174)	2.13910226
70	Persistence of primary teeth (HP:0006335)	2.12396173
71	Menorrhagia (HP:0000132)	2.12195411
72	Petechiae (HP:0000967)	2.11336534
73	Pulmonary embolism (HP:0002204)	2.08744080
74	Ventricular fibrillation (HP:0001663)	2.08689926
75	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.04239748
76	Frequent falls (HP:0002359)	2.02289950
77	Tongue fasciculations (HP:0001308)	2.02188465
78	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.00484593
79	Hemoptysis (HP:0002105)	1.99742186
80	Abnormality of renin-angiotensin system (HP:0000847)	1.98337739
81	Amelogenesis imperfecta (HP:0000705)	1.97365831
82	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.96020664
83	Decreased central vision (HP:0007663)	1.95532007
84	Dyschromatopsia (HP:0007641)	1.94588424
85	Abnormality of the left ventricular outflow tract (HP:0011103)	1.94563422
86	Subaortic stenosis (HP:0001682)	1.94563422
87	Paraplegia (HP:0010550)	1.94088441
88	Epistaxis (HP:0000421)	1.91746028
89	Pancreatic fibrosis (HP:0100732)	1.88417820
90	Atrioventricular block (HP:0001678)	1.87608797
91	Opisthotonus (HP:0002179)	1.87512478
92	Gangrene (HP:0100758)	1.85482377
93	Abnormal pupillary function (HP:0007686)	1.84243048
94	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	1.82565830
95	Abnormal eating behavior (HP:0100738)	1.81486886
96	Bicuspid aortic valve (HP:0001647)	1.80563701
97	Glomerulopathy (HP:0100820)	1.77941342
98	Peripheral demyelination (HP:0011096)	1.77343091
99	Steppage gait (HP:0003376)	1.75727168
100	Tapered finger (HP:0001182)	1.75150422

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	9.14970058
2	WNK3	6.81919160
3	TXK	5.14061945
4	PINK1	3.88374372
5	BLK	3.19048474
6	EEF2K	2.81121821
7	MAPKAPK3	2.72563225
8	ZAK	2.19581577
9	YES1	2.16802920
10	FER	2.10119135
11	IRAK1	1.61030023
12	ADRBK2	1.55469414
13	MAPKAPK5	1.51424678
14	NTRK3	1.48482624
15	CDK12	1.48291413
16	TRPM7	1.44500374
17	TAOK3	1.20847960
18	PRKCZ	1.20037237
19	CSF1R	1.12423499
20	JAK1	1.08640079
21	MST4	1.01979192
22	OXSR1	1.00830633
23	CSK	1.00306302
24	GRK1	0.99525126
25	MAPK13	0.95603375
26	BMX	0.91772251
27	STK39	0.89088582
28	TEC	0.83468843
29	MAPK11	0.76102133
30	ADRBK1	0.75909240
31	PIK3CA	0.74643076
32	DAPK2	0.72459287
33	PTK2B	0.71925043
34	MYLK	0.69593668
35	BTK	0.67727890
36	GRK5	0.65648978
37	PRKG1	0.64333347
38	PRKCH	0.63129984
39	BMPR2	0.61397237
40	RIPK4	0.61251249
41	STK24	0.60417140
42	PDK1	0.59776693
43	TLK1	0.59390009
44	PRKD2	0.58777289
45	STK38L	0.55777419
46	EIF2AK2	0.54060415
47	EIF2AK3	0.53983183
48	IGF1R	0.51898683
49	PRKD3	0.51650589
50	TYK2	0.51591772
51	PLK2	0.51082088
52	PRKCA	0.50388482
53	MAP2K1	0.49474234
54	PRKCB	0.48027058
55	LMTK2	0.46589497
56	BMPR1B	0.45639328
57	SYK	0.45320480
58	WNK4	0.43345834
59	CAMK2A	0.43248651
60	STK3	0.42584535
61	LYN	0.42154344
62	CAMK1	0.41833331
63	GRK7	0.40917474
64	TNK2	0.40530092
65	GSK3A	0.39963719
66	FLT3	0.39334586
67	CHEK2	0.36481468
68	MAPK12	0.34294995
69	LIMK1	0.33809314
70	PIK3CG	0.31517473
71	RPS6KB2	0.30927530
72	PRKCQ	0.29578866
73	EPHA4	0.28365329
74	RET	0.28159691
75	PRKACA	0.27993502
76	ITK	0.27621033
77	TNIK	0.26448996
78	PRKG2	0.25553995
79	PLK4	0.25160713
80	RPS6KA5	0.23563778
81	TIE1	0.23149307
82	MAP3K7	0.23029767
83	BCKDK	0.22925594
84	IKBKB	0.22808717
85	DAPK1	0.22563927
86	PRKCE	0.21122932
87	PDPK1	0.20319460
88	PRKCG	0.20298006
89	INSR	0.20034992
90	RPS6KA3	0.19968649
91	NEK1	0.18705934
92	ACVR1B	0.17338206
93	PRKACG	0.17325217
94	TYRO3	0.16641814
95	MAP2K7	0.16519876
96	NUAK1	0.16041998
97	CSNK1A1	0.15727489
98	MAPK10	0.14432725
99	FGR	0.14045205
100	ERBB2	0.14037330

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosaminoglycan degradation_Homo sapiens_hsa00531	6.36434141
2	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	3.35754193
3	Selenocompound metabolism_Homo sapiens_hsa00450	3.09881508
4	Arachidonic acid metabolism_Homo sapiens_hsa00590	2.74842867
5	Linoleic acid metabolism_Homo sapiens_hsa00591	2.74133672
6	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.25711995
7	Nicotine addiction_Homo sapiens_hsa05033	2.24475712
8	Ether lipid metabolism_Homo sapiens_hsa00565	2.22920111
9	Serotonergic synapse_Homo sapiens_hsa04726	2.17501830
10	Butanoate metabolism_Homo sapiens_hsa00650	2.11097856
11	Phototransduction_Homo sapiens_hsa04744	1.99401705
12	Histidine metabolism_Homo sapiens_hsa00340	1.97374033
13	Calcium signaling pathway_Homo sapiens_hsa04020	1.94698935
14	Salivary secretion_Homo sapiens_hsa04970	1.94590916
15	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.89704092
16	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.83056430
17	Propanoate metabolism_Homo sapiens_hsa00640	1.75942622
18	Glycerolipid metabolism_Homo sapiens_hsa00561	1.75011611
19	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.72534417
20	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.65427754
21	Platelet activation_Homo sapiens_hsa04611	1.60411204
22	Fat digestion and absorption_Homo sapiens_hsa04975	1.58002602
23	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.46058647
24	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.45823738
25	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.44415246
26	Olfactory transduction_Homo sapiens_hsa04740	1.44238142
27	Morphine addiction_Homo sapiens_hsa05032	1.39772746
28	Glutathione metabolism_Homo sapiens_hsa00480	1.36209897
29	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.27992783
30	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.27688720
31	cAMP signaling pathway_Homo sapiens_hsa04024	1.26846627
32	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.22411529
33	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.15030395
34	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.14769665
35	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.14293795
36	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.10810849
37	Cholinergic synapse_Homo sapiens_hsa04725	1.09212515
38	Nitrogen metabolism_Homo sapiens_hsa00910	1.08698507
39	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.04008599
40	Gastric acid secretion_Homo sapiens_hsa04971	1.00786492
41	Tryptophan metabolism_Homo sapiens_hsa00380	0.99636750
42	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.90854915
43	Proteasome_Homo sapiens_hsa03050	0.88809074
44	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.87177138
45	ABC transporters_Homo sapiens_hsa02010	0.87062551
46	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.85910891
47	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.82915688
48	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.82531483
49	Pancreatic secretion_Homo sapiens_hsa04972	0.82023890
50	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.80012416
51	GABAergic synapse_Homo sapiens_hsa04727	0.78590259
52	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.71641127
53	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.71244306
54	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.69691763
55	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.66000172
56	Peroxisome_Homo sapiens_hsa04146	0.65093698
57	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.64550495
58	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.64207725
59	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.62539817
60	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.62200047
61	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.61219950
62	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.60668806
63	African trypanosomiasis_Homo sapiens_hsa05143	0.60462403
64	Fatty acid metabolism_Homo sapiens_hsa01212	0.58164685
65	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.55623696
66	Fatty acid degradation_Homo sapiens_hsa00071	0.54392002
67	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.52763817
68	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.51338398
69	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.50349459
70	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.49428186
71	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.45875334
72	Protein digestion and absorption_Homo sapiens_hsa04974	0.45503044
73	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.42349382
74	Chemical carcinogenesis_Homo sapiens_hsa05204	0.42189954
75	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.41457129
76	Long-term depression_Homo sapiens_hsa04730	0.39763911
77	Circadian entrainment_Homo sapiens_hsa04713	0.39449159
78	Ras signaling pathway_Homo sapiens_hsa04014	0.36715369
79	Taste transduction_Homo sapiens_hsa04742	0.35542145
80	Metabolic pathways_Homo sapiens_hsa01100	0.32964368
81	Choline metabolism in cancer_Homo sapiens_hsa05231	0.31764513
82	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.29563369
83	ECM-receptor interaction_Homo sapiens_hsa04512	0.27899927
84	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.27199513
85	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.26764000
86	Primary immunodeficiency_Homo sapiens_hsa05340	0.26614568
87	Chemokine signaling pathway_Homo sapiens_hsa04062	0.25855396
88	Lysosome_Homo sapiens_hsa04142	0.23059173
89	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.22972794
90	Collecting duct acid secretion_Homo sapiens_hsa04966	0.21885153
91	Glutamatergic synapse_Homo sapiens_hsa04724	0.21251167
92	Fanconi anemia pathway_Homo sapiens_hsa03460	0.21166801
93	Arginine and proline metabolism_Homo sapiens_hsa00330	0.19362360
94	PPAR signaling pathway_Homo sapiens_hsa03320	0.19316751
95	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.19315849
96	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.18780782
97	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.17744576
98	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.17177296
99	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.17051938
100	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.17044810

SNAPC5P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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