SNAPIN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a coiled-coil-forming protein that associates with the SNARE (soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor) complex of proteins and the BLOC-1 (biogenesis of lysosome-related organelles) complex. Biochemical studies have identified additional binding partners. As part of the SNARE complex, it is required for vesicle docking and fusion and regulates neurotransmitter release. The BLOC-1 complex is required for the biogenesis of specialized organelles such as melanosomes and platelet dense granules. Mutations in gene products that form the BLOC-1 complex have been identified in mouse strains that are models of Hermansky-Pudlak syndrome. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)7.34743367
2central nervous system myelination (GO:0022010)7.34743367
3deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.73291836
4fatty acid elongation (GO:0030497)4.54191251
5establishment of protein localization to mitochondrial membrane (GO:0090151)4.47332243
6cullin deneddylation (GO:0010388)4.27419439
7negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.25989737
8regulation of cellular amino acid metabolic process (GO:0006521)4.24488746
9positive regulation of mitochondrial calcium ion concentration (GO:0051561)4.21198424
10cytochrome complex assembly (GO:0017004)4.18445471
11protein deneddylation (GO:0000338)4.17379622
12positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.03271288
13DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.02835243
14regulation of mitochondrial translation (GO:0070129)3.97281753
15RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.91154714
16tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.91154714
17signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.89439433
18signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.89439433
19signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.89439433
20regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.89137537
21signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.89110531
22intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.89110531
23negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.87362776
24negative regulation of ligase activity (GO:0051352)3.87362776
25myelin maintenance (GO:0043217)3.79790394
26myelination (GO:0042552)3.78843261
27negative regulation of protein localization to cell surface (GO:2000009)3.76809988
28axon ensheathment (GO:0008366)3.75787441
29ensheathment of neurons (GO:0007272)3.75787441
30signal transduction involved in DNA damage checkpoint (GO:0072422)3.70175193
31signal transduction involved in DNA integrity checkpoint (GO:0072401)3.70175193
32anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.68788649
33signal transduction involved in cell cycle checkpoint (GO:0072395)3.67830675
34deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.66389697
35platelet dense granule organization (GO:0060155)3.62079298
36protein targeting to mitochondrion (GO:0006626)3.58931257
37ubiquinone biosynthetic process (GO:0006744)3.55981053
38pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.54134340
39pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.53961862
40termination of RNA polymerase III transcription (GO:0006386)3.51948758
41transcription elongation from RNA polymerase III promoter (GO:0006385)3.51948758
42mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.51421884
43positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.47293423
44oxidative phosphorylation (GO:0006119)3.46757711
45photoreceptor cell differentiation (GO:0046530)3.40450733
46eye photoreceptor cell differentiation (GO:0001754)3.40450733
47antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.38512726
482-deoxyribonucleotide biosynthetic process (GO:0009265)3.38413653
49deoxyribose phosphate biosynthetic process (GO:0046385)3.38413653
50purine nucleotide salvage (GO:0032261)3.36876438
51substantia nigra development (GO:0021762)3.36591853
52protein localization to mitochondrion (GO:0070585)3.35648723
53establishment of protein localization to mitochondrion (GO:0072655)3.34233343
54inner mitochondrial membrane organization (GO:0007007)3.32999032
55positive regulation of ligase activity (GO:0051351)3.32501350
56long-chain fatty acid biosynthetic process (GO:0042759)3.29634162
57mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.28135528
58deoxyribonucleotide catabolic process (GO:0009264)3.27582545
59branched-chain amino acid catabolic process (GO:0009083)3.25953053
60creatine metabolic process (GO:0006600)3.25264573
61daunorubicin metabolic process (GO:0044597)3.24288672
62polyketide metabolic process (GO:0030638)3.24288672
63doxorubicin metabolic process (GO:0044598)3.24288672
64nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.22921031
65positive regulation of mitochondrial fission (GO:0090141)3.21611265
66phagocytosis, engulfment (GO:0006911)3.21320474
67positive regulation of oligodendrocyte differentiation (GO:0048714)3.17823185
68deoxyribose phosphate catabolic process (GO:0046386)3.15926254
69ubiquinone metabolic process (GO:0006743)3.15785593
70oligodendrocyte differentiation (GO:0048709)3.13127716
71base-excision repair, AP site formation (GO:0006285)3.12180410
72regulation of cellular amine metabolic process (GO:0033238)3.11495604
73antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.10193555
74exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.08996180
75virion attachment to host cell (GO:0019062)3.08935065
76adhesion of symbiont to host cell (GO:0044650)3.08935065
77purine nucleoside triphosphate biosynthetic process (GO:0009145)3.08614420
78enteric nervous system development (GO:0048484)3.07902776
79deoxyribose phosphate metabolic process (GO:0019692)3.07645508
80DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.07565990
81water-soluble vitamin biosynthetic process (GO:0042364)3.07531493
82ATP synthesis coupled proton transport (GO:0015986)3.03960587
83energy coupled proton transport, down electrochemical gradient (GO:0015985)3.03960587
84aldehyde catabolic process (GO:0046185)3.03933605
85purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.02643320
86respiratory electron transport chain (GO:0022904)3.02198039
872-deoxyribonucleotide metabolic process (GO:0009394)3.00421466
88negative regulation of execution phase of apoptosis (GO:1900118)2.99106828
89regulation of ubiquitin-protein transferase activity (GO:0051438)2.97952250
90regulation of collateral sprouting (GO:0048670)2.97148847
91L-amino acid import (GO:0043092)2.96324295
92ATP biosynthetic process (GO:0006754)2.95928220
93electron transport chain (GO:0022900)2.95357456
94hydrogen ion transmembrane transport (GO:1902600)2.94992165
95sequestering of actin monomers (GO:0042989)2.94069925
96amino acid salvage (GO:0043102)2.93520511
97L-methionine salvage (GO:0071267)2.93520511
98L-methionine biosynthetic process (GO:0071265)2.93520511
99guanosine-containing compound biosynthetic process (GO:1901070)2.93369391
100mitochondrial transport (GO:0006839)2.93084227
101purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.91210225
102deoxyribonucleotide metabolic process (GO:0009262)2.89913193
103DNA deamination (GO:0045006)2.88668942
104membrane raft organization (GO:0031579)2.88480012
105regulation of ligase activity (GO:0051340)2.87677738
106antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.86432343
107protein complex biogenesis (GO:0070271)2.85710299
108negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.85559324
109L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.84638777
110mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.83469648
111mitochondrial respiratory chain complex I assembly (GO:0032981)2.83469648
112NADH dehydrogenase complex assembly (GO:0010257)2.83469648
113positive regulation of cell cycle arrest (GO:0071158)2.83126103
114peptidyl-histidine modification (GO:0018202)2.82879486
115mitochondrial calcium ion homeostasis (GO:0051560)2.82702574
116purine-containing compound salvage (GO:0043101)2.82464328
117regulation of relaxation of muscle (GO:1901077)2.80063417
118GPI anchor biosynthetic process (GO:0006506)2.79979822
119C-terminal protein amino acid modification (GO:0018410)2.79544847
120dermatan sulfate metabolic process (GO:0030205)2.78957214
121intracellular protein transmembrane import (GO:0044743)2.78611409
122dermatan sulfate biosynthetic process (GO:0030208)2.73887324
123negative regulation of neurotransmitter secretion (GO:0046929)2.72748150
124amyloid precursor protein metabolic process (GO:0042982)2.72616780
125proteasome assembly (GO:0043248)2.69679497
126extracellular fibril organization (GO:0043206)2.69276955
127mannosylation (GO:0097502)2.69164725
128cholesterol biosynthetic process (GO:0006695)2.67910195
129astrocyte development (GO:0014002)2.65116345
130amyloid precursor protein catabolic process (GO:0042987)2.64621793
131signal peptide processing (GO:0006465)2.62572381
132negative regulation of neurotransmitter transport (GO:0051589)2.60792806
133myelination in peripheral nervous system (GO:0022011)2.57857980
134peripheral nervous system axon ensheathment (GO:0032292)2.57857980
135peripheral nervous system neuron development (GO:0048935)2.55834894
136neutrophil activation involved in immune response (GO:0002283)2.50297304
137blood vessel maturation (GO:0001955)2.50008976
138glial cell development (GO:0021782)2.49803370
139negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.49532289
140sterol biosynthetic process (GO:0016126)2.48719656
141fibril organization (GO:0097435)2.47632420
142substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.46485503
143substrate-independent telencephalic tangential migration (GO:0021826)2.46485503
144regulation of somitogenesis (GO:0014807)2.44312207
145regulation of metalloenzyme activity (GO:0048552)2.43908344
146response to redox state (GO:0051775)2.42344743
147response to muscle activity (GO:0014850)2.41584046
148mitochondrial respiratory chain complex assembly (GO:0033108)2.40388072
149protein neddylation (GO:0045116)2.39822677
150chaperone-mediated protein transport (GO:0072321)2.39444822
151intracellular pH reduction (GO:0051452)2.39206687
152GPI anchor metabolic process (GO:0006505)2.39164467
153neurotransmitter uptake (GO:0001504)2.38900358
154axoneme assembly (GO:0035082)2.38677917
155positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.38378096
156mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.38378096
157nuclear envelope reassembly (GO:0031468)2.36318235
158mitotic nuclear envelope reassembly (GO:0007084)2.36318235
159lateral sprouting from an epithelium (GO:0060601)2.35110853
160negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.34705455
161metallo-sulfur cluster assembly (GO:0031163)2.32991434
162iron-sulfur cluster assembly (GO:0016226)2.32991434
163detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.32804779
164detection of temperature stimulus involved in sensory perception (GO:0050961)2.32804779
165Golgi to plasma membrane protein transport (GO:0043001)2.32441857
166axon development (GO:0061564)2.32136456
167mitochondrion degradation (GO:0000422)2.31318165
168amino acid import (GO:0043090)2.31085627
169C-terminal protein lipidation (GO:0006501)2.30932411
170response to methylmercury (GO:0051597)2.30895689
171positive regulation of vasculogenesis (GO:2001214)2.30233776
172peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.28351613
173respiratory chain complex IV assembly (GO:0008535)2.25339533
174GTP biosynthetic process (GO:0006183)2.25006140
175import into cell (GO:0098657)2.24495028

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.86127599
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.90483299
3* ETS1_20019798_ChIP-Seq_JURKAT_Human3.48996741
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.18131186
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.81434736
6VDR_23849224_ChIP-Seq_CD4+_Human2.81056445
7PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.56918329
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.54135721
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.49287587
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.43312383
11FOXP3_21729870_ChIP-Seq_TREG_Human2.41284165
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.41258258
13THAP11_20581084_ChIP-Seq_MESCs_Mouse2.38464056
14ELK1_19687146_ChIP-ChIP_HELA_Human2.38417567
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.30097895
16DCP1A_22483619_ChIP-Seq_HELA_Human2.26443857
17GABP_19822575_ChIP-Seq_HepG2_Human2.24057489
18LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.23856748
19SRF_21415370_ChIP-Seq_HL-1_Mouse2.10493322
20PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.05348342
21TRIM28_21343339_ChIP-Seq_HEK293_Human2.05313670
22SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.96536697
23PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.89682959
24MYC_19030024_ChIP-ChIP_MESCs_Mouse1.88641454
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.87736380
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.85679934
27CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.83661251
28ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.80122402
29CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.79817470
30YY1_21170310_ChIP-Seq_MESCs_Mouse1.76568914
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.75068093
32E2F4_17652178_ChIP-ChIP_JURKAT_Human1.74505877
33GABP_17652178_ChIP-ChIP_JURKAT_Human1.74243527
34NELFA_20434984_ChIP-Seq_ESCs_Mouse1.71826631
35CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.71096209
36MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.68909414
37MYC_18940864_ChIP-ChIP_HL60_Human1.66492704
38TTF2_22483619_ChIP-Seq_HELA_Human1.62393652
39XRN2_22483619_ChIP-Seq_HELA_Human1.60644334
40RUNX_20019798_ChIP-Seq_JUKART_Human1.58752821
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.57402472
42ZNF274_21170338_ChIP-Seq_K562_Hela1.55084725
43NRF2_20460467_ChIP-Seq_MEFs_Mouse1.54629881
44NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.54629881
45TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.53669289
46CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.52394522
47RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.52271803
48EOMES_21245162_ChIP-Seq_HESCs_Human1.51586584
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.50807370
50POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.49721672
51IRF8_21731497_ChIP-ChIP_J774_Mouse1.49415803
52FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.48423889
53MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.45808119
54IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.45595875
55PADI4_21655091_ChIP-ChIP_MCF-7_Human1.45566895
56WT1_19549856_ChIP-ChIP_CCG9911_Human1.43483089
57BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.42991640
58FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.39843684
59PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36321418
60AR_21572438_ChIP-Seq_LNCaP_Human1.35496195
61CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.31765956
62SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.31394418
63ER_23166858_ChIP-Seq_MCF-7_Human1.26039296
64TP53_22573176_ChIP-Seq_HFKS_Human1.25137347
65CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.24201547
66KDM5A_27292631_Chip-Seq_BREAST_Human1.23133767
67CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.23109916
68MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.23007479
69SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.22231789
70SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.22197050
71SMC3_22415368_ChIP-Seq_MEFs_Mouse1.21829901
72PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.21587022
73ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.21385388
74SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.20518034
75OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19327293
76ERG_20887958_ChIP-Seq_HPC-7_Mouse1.19091808
77CREB1_15753290_ChIP-ChIP_HEK293T_Human1.18401347
78KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.17795727
79STAT4_19710469_ChIP-ChIP_TH1__Mouse1.17471867
80NANOG_20526341_ChIP-Seq_ESCs_Human1.15033708
81NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.14982991
82SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.14092831
83SA1_22415368_ChIP-Seq_MEFs_Mouse1.13643872
84YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13238353
85JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.12156442
86EST1_17652178_ChIP-ChIP_JURKAT_Human1.11677664
87ELK1_22589737_ChIP-Seq_MCF10A_Human1.11613414
88NFI_21473784_ChIP-Seq_ESCs_Mouse1.09832103
89POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.08916926
90HOXB4_20404135_ChIP-ChIP_EML_Mouse1.07671145
91MYCN_18555785_ChIP-Seq_MESCs_Mouse1.07207125
92HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.07167429
93SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06661983
94MTF2_20144788_ChIP-Seq_MESCs_Mouse1.06505556
95FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.06485378
96CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.06153201
97EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04640685
98* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03697428
99MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.03592312
100ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02943254
101EGR1_19032775_ChIP-ChIP_M12_Human1.02367261
102CJUN_26792858_Chip-Seq_BT549_Human1.02320207
103HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.01497479
104CIITA_25753668_ChIP-Seq_RAJI_Human1.00699780
105ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.00212560
106CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.00075773
107DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98225246
108IRF8_22096565_ChIP-ChIP_GC-B_Human0.97835886
109HTT_18923047_ChIP-ChIP_STHdh_Human0.97708688
110* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.97569151
111MYC_19079543_ChIP-ChIP_MESCs_Mouse0.96824223
112JARID2_20064375_ChIP-Seq_MESCs_Mouse0.96055382
113IRF8_27001747_Chip-Seq_BMDM_Mouse0.96036459
114EED_16625203_ChIP-ChIP_MESCs_Mouse0.94525993
115SOX2_20726797_ChIP-Seq_SW620_Human0.94081773
116MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.93833754
117TFEB_21752829_ChIP-Seq_HELA_Human0.93701264
118ZFX_18555785_ChIP-Seq_MESCs_Mouse0.93665025
119TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.93633642
120CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93601092
121MYB_21317192_ChIP-Seq_ERMYB_Mouse0.93309389
122IRF1_19129219_ChIP-ChIP_H3396_Human0.92941201
123ELF1_17652178_ChIP-ChIP_JURKAT_Human0.92386329
124IGF1R_20145208_ChIP-Seq_DFB_Human0.91781911
125PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.91778087
126* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.91620025
127* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.91354193
128ZFP57_27257070_Chip-Seq_ESCs_Mouse0.90479027
129TAL1_26923725_Chip-Seq_HPCs_Mouse0.90163672
130FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90079735
131GATA2_21666600_ChIP-Seq_HMVEC_Human0.89878590
132EWS_26573619_Chip-Seq_HEK293_Human0.89767797
133AR_20517297_ChIP-Seq_VCAP_Human0.89264392
134PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.89005547
135SOX2_19829295_ChIP-Seq_ESCs_Human0.87725563
136NANOG_19829295_ChIP-Seq_ESCs_Human0.87725563
137SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.87216429
138EZH2_27304074_Chip-Seq_ESCs_Mouse0.87020850
139PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86958385
140EGR1_23403033_ChIP-Seq_LIVER_Mouse0.86688191
141SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.86620710
142SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.86049436
143TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85565940
144SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.84661821
145RNF2_18974828_ChIP-Seq_MESCs_Mouse0.84436636
146EZH2_18974828_ChIP-Seq_MESCs_Mouse0.84436636
147SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.84293201
148ERG_20517297_ChIP-Seq_VCAP_Human0.83982406
149CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83552369
150NANOG_18555785_ChIP-Seq_MESCs_Mouse0.83518800
151NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.83306303
152SCL_19346495_ChIP-Seq_HPC-7_Human0.83259454
153JARID2_20075857_ChIP-Seq_MESCs_Mouse0.83223306
154SMC1_22415368_ChIP-Seq_MEFs_Mouse0.82907287
155EP300_21415370_ChIP-Seq_HL-1_Mouse0.82484075
156E2F1_18555785_ChIP-Seq_MESCs_Mouse0.82313329
157CTCF_18555785_ChIP-Seq_MESCs_Mouse0.81958700
158P63_26484246_Chip-Seq_KERATINOCYTES_Human0.81849390
159BP1_19119308_ChIP-ChIP_Hs578T_Human0.81564022
160SRY_22984422_ChIP-ChIP_TESTIS_Rat0.80790370
161EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.79110911
162VDR_22108803_ChIP-Seq_LS180_Human0.78584825
163NOTCH1_21737748_ChIP-Seq_TLL_Human0.77994154
164TBX5_21415370_ChIP-Seq_HL-1_Mouse0.77833371
165RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.76179144
166FOXP1_21924763_ChIP-Seq_HESCs_Human0.76083998
167* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.75220553

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis3.97951264
2MP0000920_abnormal_myelination3.41782694
3MP0002102_abnormal_ear_morphology3.35561056
4MP0008058_abnormal_DNA_repair3.26450827
5MP0008438_abnormal_cutaneous_collagen2.97497471
6MP0000749_muscle_degeneration2.71592558
7MP0002837_dystrophic_cardiac_calcinosis2.70204968
8MP0003011_delayed_dark_adaptation2.49543915
9MP0006035_abnormal_mitochondrial_morpho2.46058234
10MP0008789_abnormal_olfactory_epithelium2.39530818
11MP0003718_maternal_effect2.19278730
12MP0003724_increased_susceptibility_to2.15026509
13MP0001958_emphysema2.12494056
14MP0003279_aneurysm2.06619646
15MP0002736_abnormal_nociception_after2.06181089
16MP0000372_irregular_coat_pigmentation2.04025109
17MP0006072_abnormal_retinal_apoptosis2.03310088
18MP0000747_muscle_weakness2.02406197
19MP0005058_abnormal_lysosome_morphology2.00567779
20MP0009697_abnormal_copulation1.95418070
21MP0005275_abnormal_skin_tensile1.91712407
22MP0005503_abnormal_tendon_morphology1.88878441
23MP0003690_abnormal_glial_cell1.88779300
24MP0001905_abnormal_dopamine_level1.88737444
25MP0003950_abnormal_plasma_membrane1.84447930
26MP0001529_abnormal_vocalization1.76682028
27MP0002933_joint_inflammation1.74982861
28MP0003634_abnormal_glial_cell1.72861798
29MP0004145_abnormal_muscle_electrophysio1.72271346
30MP0004147_increased_porphyrin_level1.70848410
31MP0000751_myopathy1.70731623
32MP0003329_amyloid_beta_deposits1.69653808
33MP0002653_abnormal_ependyma_morphology1.69057724
34MP0003786_premature_aging1.68554500
35MP0005171_absent_coat_pigmentation1.68254079
36MP0004142_abnormal_muscle_tone1.66514406
37MP0000358_abnormal_cell_content/1.65205142
38MP0009384_cardiac_valve_regurgitation1.63814254
39MP0002638_abnormal_pupillary_reflex1.63339904
40MP0010094_abnormal_chromosome_stability1.62334587
41MP0001986_abnormal_taste_sensitivity1.62087128
42MP0008007_abnormal_cellular_replicative1.59818673
43MP0001542_abnormal_bone_strength1.57721977
44MP0009379_abnormal_foot_pigmentation1.54622546
45MP0002148_abnormal_hypersensitivity_rea1.54596284
46MP0000343_altered_response_to1.54157490
47MP0004036_abnormal_muscle_relaxation1.51475111
48MP0003136_yellow_coat_color1.51089475
49MP0000685_abnormal_immune_system1.47342737
50MP0000516_abnormal_urinary_system1.43605415
51MP0005367_renal/urinary_system_phenotyp1.43605415
52MP0001968_abnormal_touch/_nociception1.38052012
53MP0002090_abnormal_vision1.37782547
54MP0008932_abnormal_embryonic_tissue1.36625102
55MP0008569_lethality_at_weaning1.34372403
56MP0001835_abnormal_antigen_presentation1.33218286
57MP0005671_abnormal_response_to1.30360173
58MP0003646_muscle_fatigue1.29167152
59MP0001764_abnormal_homeostasis1.28377140
60MP0008875_abnormal_xenobiotic_pharmacok1.27185413
61MP0005394_taste/olfaction_phenotype1.26756556
62MP0005499_abnormal_olfactory_system1.26756556
63MP0009785_altered_susceptibility_to1.25538865
64MP0008260_abnormal_autophagy1.24430759
65MP0002822_catalepsy1.20296737
66MP0003186_abnormal_redox_activity1.15557140
67MP0002108_abnormal_muscle_morphology1.13406340
68MP0008775_abnormal_heart_ventricle1.12864161
69MP0010030_abnormal_orbit_morphology1.12055164
70MP0003183_abnormal_peptide_metabolism1.11844696
71MP0003077_abnormal_cell_cycle1.11502016
72MP0009250_abnormal_appendicular_skeleto1.11484756
73MP0005408_hypopigmentation1.11139281
74MP0005165_increased_susceptibility_to1.09507023
75MP0004084_abnormal_cardiac_muscle1.08894746
76MP0002163_abnormal_gland_morphology1.08474138
77MP0005000_abnormal_immune_tolerance1.07975628
78MP0001348_abnormal_lacrimal_gland1.07733036
79MP0005369_muscle_phenotype1.06974462
80MP0004215_abnormal_myocardial_fiber1.06367694
81MP0001851_eye_inflammation1.05380440
82MP0006054_spinal_hemorrhage1.04150103
83MP0001346_abnormal_lacrimal_gland1.03976596
84MP0005646_abnormal_pituitary_gland1.03693907
85MP0008872_abnormal_physiological_respon1.02757540
86MP0001661_extended_life_span1.01853063
87MP0008877_abnormal_DNA_methylation1.01505051
88MP0005332_abnormal_amino_acid1.01359868
89MP0006276_abnormal_autonomic_nervous1.01326886
90MP0001299_abnormal_eye_distance/1.01136943
91MP0001984_abnormal_olfaction1.00878398
92MP0002234_abnormal_pharynx_morphology1.00563556
93MP0002106_abnormal_muscle_physiology1.00117026
94MP0004381_abnormal_hair_follicle0.99380830
95MP0002095_abnormal_skin_pigmentation0.99063915
96MP0002419_abnormal_innate_immunity0.98163101
97MP0005330_cardiomyopathy0.97792163
98MP0002876_abnormal_thyroid_physiology0.96606862
99MP0005551_abnormal_eye_electrophysiolog0.95865308
100MP0000049_abnormal_middle_ear0.95644905
101MP0005167_abnormal_blood-brain_barrier0.95220930
102MP0000759_abnormal_skeletal_muscle0.94310503
103MP0005025_abnormal_response_to0.93329289
104MP0009046_muscle_twitch0.92947851
105MP0002972_abnormal_cardiac_muscle0.92529549
106MP0000465_gastrointestinal_hemorrhage0.92263509
107MP0004134_abnormal_chest_morphology0.91096415
108MP0006036_abnormal_mitochondrial_physio0.90813542
109MP0005508_abnormal_skeleton_morphology0.90350159
110MP0000604_amyloidosis0.90209915
111MP0005595_abnormal_vascular_smooth0.90118446
112MP0002938_white_spotting0.90083330
113MP0005620_abnormal_muscle_contractility0.88273061
114MP0001324_abnormal_eye_pigmentation0.88061746
115MP0002160_abnormal_reproductive_system0.88026693
116MP0010386_abnormal_urinary_bladder0.87995131
117MP0005379_endocrine/exocrine_gland_phen0.87959184
118MP0001485_abnormal_pinna_reflex0.87872550
119MP0003693_abnormal_embryo_hatching0.87333103
120MP0005410_abnormal_fertilization0.87061841
121MP0006292_abnormal_olfactory_placode0.86957399
122MP0003137_abnormal_impulse_conducting0.86831713
123MP0001486_abnormal_startle_reflex0.86218154
124MP0003172_abnormal_lysosome_physiology0.84428112
125MP0001929_abnormal_gametogenesis0.84376443
126MP0002272_abnormal_nervous_system0.83483704
127MP0002229_neurodegeneration0.82643271
128MP0003111_abnormal_nucleus_morphology0.82367304
129MP0002210_abnormal_sex_determination0.82128350
130MP0001533_abnormal_skeleton_physiology0.81014205
131MP0005253_abnormal_eye_physiology0.80844143
132MP0002751_abnormal_autonomic_nervous0.79867234
133MP0001293_anophthalmia0.79654336
134MP0003880_abnormal_central_pattern0.79472654
135MP0004087_abnormal_muscle_fiber0.79460348
136MP0001853_heart_inflammation0.79094355
137MP0003075_altered_response_to0.78116224
138MP0005084_abnormal_gallbladder_morpholo0.77437933
139MP0005390_skeleton_phenotype0.77390998
140MP0009764_decreased_sensitivity_to0.76911251
141MP0002723_abnormal_immune_serum0.76683543
142MP0004885_abnormal_endolymph0.76464823
143MP0004130_abnormal_muscle_cell0.75905012
144MP0003633_abnormal_nervous_system0.75891484
145MP0005319_abnormal_enzyme/_coenzyme0.75709490
146MP0005645_abnormal_hypothalamus_physiol0.75501338
147MP0000653_abnormal_sex_gland0.74217685
148MP0005075_abnormal_melanosome_morpholog0.73911569
149MP0002282_abnormal_trachea_morphology0.73512674
150MP0002735_abnormal_chemical_nociception0.73386205
151MP0005174_abnormal_tail_pigmentation0.72998237
152MP0005266_abnormal_metabolism0.72812543
153MP0000681_abnormal_thyroid_gland0.72439555
154MP0000750_abnormal_muscle_regeneration0.71858652
155MP0005389_reproductive_system_phenotype0.71710099
156MP0000647_abnormal_sebaceous_gland0.71693737
157MP0003656_abnormal_erythrocyte_physiolo0.71643173
158MP0004133_heterotaxia0.69625732
159MP0004742_abnormal_vestibular_system0.69309504
160MP0001119_abnormal_female_reproductive0.67868733
161MP0003195_calcinosis0.67383142
162MP0005670_abnormal_white_adipose0.67196197
163MP0005584_abnormal_enzyme/coenzyme_acti0.66679888
164MP0008873_increased_physiological_sensi0.64686936
165MP0001145_abnormal_male_reproductive0.64035326

Predicted human phenotypes

RankGene SetZ-score
1Retinal dysplasia (HP:0007973)3.70357196
2Hepatocellular necrosis (HP:0001404)3.69351153
3Increased hepatocellular lipid droplets (HP:0006565)3.67551646
4Cerebral edema (HP:0002181)3.66111179
5Lipid accumulation in hepatocytes (HP:0006561)3.66102544
6Acute necrotizing encephalopathy (HP:0006965)3.45168314
7Abnormal mitochondria in muscle tissue (HP:0008316)3.29320668
8Increased serum lactate (HP:0002151)3.27792585
9Mitochondrial inheritance (HP:0001427)3.16810989
10Hepatic necrosis (HP:0002605)3.05554993
11Nemaline bodies (HP:0003798)3.00505497
12Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.95530402
13Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.94888235
14Neurofibrillary tangles (HP:0002185)2.90391331
15Increased neuronal autofluorescent lipopigment (HP:0002074)2.88418183
16Type I transferrin isoform profile (HP:0003642)2.86306661
17Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.84568594
18Degeneration of the lateral corticospinal tracts (HP:0002314)2.84568594
19Muscle fiber inclusion bodies (HP:0100299)2.81884615
20Segmental peripheral demyelination/remyelination (HP:0003481)2.81331597
21Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.79862912
22Hyperglycinemia (HP:0002154)2.74312379
23Dicarboxylic aciduria (HP:0003215)2.72608337
24Abnormality of dicarboxylic acid metabolism (HP:0010995)2.72608337
25Lethargy (HP:0001254)2.72221652
26Progressive macrocephaly (HP:0004481)2.70161994
27CNS demyelination (HP:0007305)2.66079092
28Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.65670503
29Patchy hypopigmentation of hair (HP:0011365)2.64921895
30Humeroradial synostosis (HP:0003041)2.64768024
31Synostosis involving the elbow (HP:0003938)2.64768024
32Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.63114580
33Decreased activity of mitochondrial respiratory chain (HP:0008972)2.63114580
34Progressive neurologic deterioration (HP:0002344)2.62477469
35Cerebral hypomyelination (HP:0006808)2.60450621
36Distal arthrogryposis (HP:0005684)2.59326963
37Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.54494428
38Megalencephaly (HP:0001355)2.53451125
39Leukodystrophy (HP:0002415)2.53099624
40Acute encephalopathy (HP:0006846)2.50510735
41Aplasia involving bones of the upper limbs (HP:0009823)2.49341534
42Aplasia of the phalanges of the hand (HP:0009802)2.49341534
43Aplasia involving bones of the extremities (HP:0009825)2.49341534
44Molar tooth sign on MRI (HP:0002419)2.48094489
45Abnormality of midbrain morphology (HP:0002418)2.48094489
46Generalized aminoaciduria (HP:0002909)2.47861436
47Increased CSF lactate (HP:0002490)2.47785044
48Peripheral hypomyelination (HP:0007182)2.43184314
493-Methylglutaconic aciduria (HP:0003535)2.39992079
50Pancreatic cysts (HP:0001737)2.38763150
51White forelock (HP:0002211)2.38632155
52Increased cerebral lipofuscin (HP:0011813)2.38495743
53Exertional dyspnea (HP:0002875)2.35526760
54Neuroendocrine neoplasm (HP:0100634)2.34535551
55Parakeratosis (HP:0001036)2.32873587
56Elevated erythrocyte sedimentation rate (HP:0003565)2.30206531
57Pancreatic fibrosis (HP:0100732)2.29997819
58Methylmalonic aciduria (HP:0012120)2.29685142
59Degeneration of anterior horn cells (HP:0002398)2.29179152
60Abnormality of the anterior horn cell (HP:0006802)2.29179152
61Ragged-red muscle fibers (HP:0003200)2.28742266
62Muscle hypertrophy of the lower extremities (HP:0008968)2.28521302
63Abnormality of the middle phalanges of the toes (HP:0010183)2.26110779
64Pheochromocytoma (HP:0002666)2.23101985
65Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.22598351
66Abnormal protein N-linked glycosylation (HP:0012347)2.22598351
67Abnormal protein glycosylation (HP:0012346)2.22598351
68Abnormal glycosylation (HP:0012345)2.22598351
69Calf muscle hypertrophy (HP:0008981)2.20813710
70Clumsiness (HP:0002312)2.20573626
71Hypothermia (HP:0002045)2.19866823
72Vertebral compression fractures (HP:0002953)2.19563835
73Emotional lability (HP:0000712)2.18892951
74Pulmonary artery stenosis (HP:0004415)2.18829942
75Microvesicular hepatic steatosis (HP:0001414)2.17388864
76Progressive microcephaly (HP:0000253)2.14862331
77Exercise intolerance (HP:0003546)2.12957989
78True hermaphroditism (HP:0010459)2.12573456
79Loss of speech (HP:0002371)2.12263252
80Respiratory failure (HP:0002878)2.09600518
81Abnormality of glycolysis (HP:0004366)2.09389008
82Increased serum pyruvate (HP:0003542)2.09389008
83Exercise-induced muscle cramps (HP:0003710)2.09147146
84Nonprogressive disorder (HP:0003680)2.08166645
85Opisthotonus (HP:0002179)2.05742420
86Poor speech (HP:0002465)2.04767843
87Abnormality of the phalanges of the 2nd finger (HP:0009541)2.04586477
88Round ear (HP:0100830)2.04475847
89Exercise-induced myalgia (HP:0003738)2.04455965
90Pancytopenia (HP:0001876)2.01398495
91Muscle fiber splitting (HP:0003555)2.01202127
92Spastic paraparesis (HP:0002313)2.00860593
93Gowers sign (HP:0003391)1.98430890
94Hyperglycinuria (HP:0003108)1.97907094
95Methylmalonic acidemia (HP:0002912)1.97571760
96Split foot (HP:0001839)1.97514615
97Abnormality of the columella (HP:0009929)1.97263873
98Increased intramyocellular lipid droplets (HP:0012240)1.95739788
99Reduced antithrombin III activity (HP:0001976)1.94060259
100Absent septum pellucidum (HP:0001331)1.93567964
101Medial flaring of the eyebrow (HP:0010747)1.93098877
102Hepatosplenomegaly (HP:0001433)1.90857297
103Aplasia/Hypoplasia of the sacrum (HP:0008517)1.90791265
104Dysostosis multiplex (HP:0000943)1.90518550
105Onion bulb formation (HP:0003383)1.90029268
106Congenital primary aphakia (HP:0007707)1.89262944
107Bile duct proliferation (HP:0001408)1.89035713
108Abnormal biliary tract physiology (HP:0012439)1.89035713
109Abnormality of glycine metabolism (HP:0010895)1.88796964
110Abnormality of serine family amino acid metabolism (HP:0010894)1.88796964
111Lactic acidosis (HP:0003128)1.88639123
112Petechiae (HP:0000967)1.88549123
113Testicular atrophy (HP:0000029)1.87800966
114Ankle clonus (HP:0011448)1.86760639
115Rhabdomyolysis (HP:0003201)1.86677364
116Progressive inability to walk (HP:0002505)1.86327531
117Renal Fanconi syndrome (HP:0001994)1.85912171
118Type 2 muscle fiber atrophy (HP:0003554)1.84913199
119Ketoacidosis (HP:0001993)1.84898727
120EMG: myopathic abnormalities (HP:0003458)1.84680549
121Renal cortical cysts (HP:0000803)1.84550412
122Increased muscle lipid content (HP:0009058)1.83373770
123Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.83302501
124Abnormality of alanine metabolism (HP:0010916)1.83302501
125Hyperalaninemia (HP:0003348)1.83302501
126X-linked dominant inheritance (HP:0001423)1.82926143
127Optic disc pallor (HP:0000543)1.82523982
128Poor head control (HP:0002421)1.82035468
129Ketosis (HP:0001946)1.81220677
130Bell-shaped thorax (HP:0001591)1.81190941
131Abnormality of glycolipid metabolism (HP:0010969)1.80301608
132Abnormality of liposaccharide metabolism (HP:0010968)1.80301608
133Abnormality of glycosphingolipid metabolism (HP:0004343)1.80301608
134Aplasia/hypoplasia of the uterus (HP:0008684)1.80243536
135Vacuolated lymphocytes (HP:0001922)1.80057815
136Chronic otitis media (HP:0000389)1.80026908
137Abnormality of macrophages (HP:0004311)1.79743907
138Recurrent abscess formation (HP:0002722)1.79017130
139Gait imbalance (HP:0002141)1.78335868
140Hypokinesia (HP:0002375)1.78045639
141Nephrogenic diabetes insipidus (HP:0009806)1.77778669
142Abnormality of renal resorption (HP:0011038)1.76930193
143Symphalangism affecting the phalanges of the hand (HP:0009773)1.76611746
144Short tibia (HP:0005736)1.75703178
145CNS hypomyelination (HP:0003429)1.75690840
146Prolonged neonatal jaundice (HP:0006579)1.75510147
147Muscle fiber atrophy (HP:0100295)1.75223635
148Calcaneovalgus deformity (HP:0001848)1.74925094
149Hypoglycemic coma (HP:0001325)1.73263941
150Abnormality of fatty-acid metabolism (HP:0004359)1.73214296
151Abnormality of the calf musculature (HP:0001430)1.72873505
152Sclerocornea (HP:0000647)1.72602978
153Neck muscle weakness (HP:0000467)1.72579907
154Median cleft lip (HP:0000161)1.71916883
155Atrophy/Degeneration involving motor neurons (HP:0007373)1.71391501
156Neoplasm of the adrenal gland (HP:0100631)1.69355640
157Aplasia/Hypoplasia of the tongue (HP:0010295)1.69166995
158Hyperammonemia (HP:0001987)1.67249906
159Abnormality of urine glucose concentration (HP:0011016)1.66937107
160Glycosuria (HP:0003076)1.66937107
161Cholecystitis (HP:0001082)1.65883972
162Abnormal gallbladder physiology (HP:0012438)1.65883972
163Blindness (HP:0000618)1.65696056

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.25587200
2MUSK3.55656979
3MAP4K23.44128004
4LIMK13.17844964
5CAMKK23.08226198
6STK393.05089076
7MAPKAPK53.00582814
8TNIK2.68591129
9ZAK2.43826777
10TRIM282.37321814
11BLK2.34056246
12CDK192.22402267
13ARAF2.17514946
14NUAK12.13443992
15PIM22.12167842
16PBK2.02023354
17STK161.95810533
18PHKG11.94039764
19PHKG21.94039764
20EIF2AK11.90636581
21NEK11.86187679
22MAP3K121.84144810
23TESK21.82101480
24KIT1.81896400
25MST41.79631753
26OXSR11.68150267
27LMTK21.64185764
28IRAK11.58863175
29IRAK41.56716025
30EPHB11.51948315
31CCNB11.49884556
32CDK81.49199231
33EIF2AK31.47805539
34BCR1.43768293
35SRPK11.41713950
36ERBB31.37685500
37PDK21.32979060
38MYLK1.32871312
39TEC1.31487311
40OBSCN1.30707883
41GRK11.29906733
42NEK91.29445830
43IRAK21.24528400
44ILK1.24016018
45MAP2K71.20212388
46TLK11.20119425
47PLK21.19205219
48ROCK21.18330414
49DAPK11.16217719
50ADRBK21.13495495
51PINK11.12502295
52CAMK1D1.08855734
53TBK11.06609535
54MAPKAPK31.06402487
55PLK31.06217289
56BMPR1B1.06128373
57ABL21.04398113
58KDR1.01230871
59CSNK1G30.99023955
60NME20.98836019
61TXK0.97830257
62WEE10.92367275
63PLK40.90540233
64BUB10.90398433
65DYRK30.90389070
66CSF1R0.89423680
67IRAK30.88987013
68NLK0.88733613
69INSRR0.88146007
70CAMK2D0.87831205
71WNK40.87163480
72TESK10.86773318
73DYRK20.86522797
74BCKDK0.85698143
75VRK10.85560417
76DMPK0.83504923
77WNK30.81785983
78PLK10.81451598
79MAP3K130.80967974
80NEK60.79932602
81MAPK130.77632090
82FRK0.77367286
83CDC70.77042987
84CAMK2G0.74965683
85PKN10.72827426
86AURKA0.70383878
87RAF10.70296535
88CSNK1G10.70176350
89GRK70.69664517
90MAP4K10.69145328
91BTK0.68079098
92GRK50.68039479
93CLK10.67164956
94ADRBK10.66779035
95ZAP700.64226406
96PRKCI0.64224627
97NTRK10.63803893
98SGK4940.63544915
99SGK2230.63544915
100CASK0.63526710
101MAP3K110.62464977
102SCYL20.62187089
103RPS6KA50.62044853
104TRIB30.61436741
105EPHA30.60882517
106IKBKE0.59632191
107CAMK2B0.59579365
108CSNK1G20.59059060
109MOS0.58559014
110CSNK1A1L0.57520857
111PRKD10.57260959
112SIK30.57038048
113AURKB0.56226239
114PRKCE0.54466764
115ROCK10.53323433
116MET0.53196932
117JAK30.52350741
118TRPM70.52147907
119PIK3CG0.51711166
120ATR0.51598657
121CDK140.51066710
122FGR0.50757319
123LCK0.50131684
124FLT30.49501271
125MAPK150.49262524
126CAMK1G0.48548305
127PRKCQ0.47874801
128MINK10.47133968
129EIF2AK20.46963046
130CSNK2A10.46816105
131BRAF0.46552892
132PRPF4B0.46521272
133DAPK30.46348909
134FES0.46092501
135YES10.45391010
136RPS6KA40.45166045
137PRKG20.45095151
138NME10.45026673
139BRSK10.44820082
140PIK3CA0.44499544
141MAPKAPK20.44014642
142LYN0.43923921
143TGFBR10.43102981
144PAK10.41982827
145MAP3K40.39411188
146CDK70.36204710
147EPHB20.35722541
148ACVR1B0.35555267
149TIE10.33772933
150PAK40.33662971
151TTK0.32244576
152PRKCG0.32112579
153MAP2K60.31983360
154CSNK2A20.31841343
155CDK90.29733816
156IKBKB0.29202653

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.76188839
2Parkinsons disease_Homo sapiens_hsa050123.35737438
3Protein export_Homo sapiens_hsa030603.30987938
4Fatty acid elongation_Homo sapiens_hsa000623.24763764
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.96423195
6Steroid biosynthesis_Homo sapiens_hsa001002.80759095
7SNARE interactions in vesicular transport_Homo sapiens_hsa041302.53693663
8Ribosome_Homo sapiens_hsa030102.46896767
9Alzheimers disease_Homo sapiens_hsa050102.43773644
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.31869463
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.30904117
12Nitrogen metabolism_Homo sapiens_hsa009102.06956068
13Mismatch repair_Homo sapiens_hsa034302.05145251
14Base excision repair_Homo sapiens_hsa034102.03449764
15Proteasome_Homo sapiens_hsa030502.03044355
16DNA replication_Homo sapiens_hsa030301.98524212
17Huntingtons disease_Homo sapiens_hsa050161.89426761
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.89059473
19Ether lipid metabolism_Homo sapiens_hsa005651.87655410
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.86121013
21Pyrimidine metabolism_Homo sapiens_hsa002401.84396639
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.83670659
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.75673178
24Sphingolipid metabolism_Homo sapiens_hsa006001.72626421
25Cardiac muscle contraction_Homo sapiens_hsa042601.68607517
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.63883952
27Lysosome_Homo sapiens_hsa041421.57375610
28Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.52263722
29Malaria_Homo sapiens_hsa051441.48766515
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.42193678
31Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.42057017
32Fanconi anemia pathway_Homo sapiens_hsa034601.35992178
33Nucleotide excision repair_Homo sapiens_hsa034201.33924467
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.27707889
35Other glycan degradation_Homo sapiens_hsa005111.25825476
36Rheumatoid arthritis_Homo sapiens_hsa053231.24021512
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.23691987
38Arachidonic acid metabolism_Homo sapiens_hsa005901.17058589
39Butanoate metabolism_Homo sapiens_hsa006501.15522290
40Carbon metabolism_Homo sapiens_hsa012001.15251812
41RNA degradation_Homo sapiens_hsa030181.14104306
42One carbon pool by folate_Homo sapiens_hsa006701.13829411
43Phagosome_Homo sapiens_hsa041451.12815103
44Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.11546155
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.09971751
46Fatty acid biosynthesis_Homo sapiens_hsa000611.05438200
47Shigellosis_Homo sapiens_hsa051311.05271823
48Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.04287533
49Spliceosome_Homo sapiens_hsa030401.03122053
50Sulfur relay system_Homo sapiens_hsa041221.02597492
51Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.02416865
52Sphingolipid signaling pathway_Homo sapiens_hsa040711.01165477
53RNA polymerase_Homo sapiens_hsa030200.97737562
54Vibrio cholerae infection_Homo sapiens_hsa051100.96786683
55Fatty acid metabolism_Homo sapiens_hsa012120.95253074
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.93766418
57Salmonella infection_Homo sapiens_hsa051320.93546205
58Autoimmune thyroid disease_Homo sapiens_hsa053200.92223296
59Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.89151324
60Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.89143621
61Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.89065622
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.87986807
63Regulation of autophagy_Homo sapiens_hsa041400.86064143
64Tryptophan metabolism_Homo sapiens_hsa003800.86000909
65Pentose phosphate pathway_Homo sapiens_hsa000300.85008922
66Biosynthesis of amino acids_Homo sapiens_hsa012300.84626541
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83036296
68Sulfur metabolism_Homo sapiens_hsa009200.82447970
69Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.78958396
70Fatty acid degradation_Homo sapiens_hsa000710.76850863
71RNA transport_Homo sapiens_hsa030130.76537366
72Glutathione metabolism_Homo sapiens_hsa004800.73840900
73Primary immunodeficiency_Homo sapiens_hsa053400.70971014
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67226449
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.66769452
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.66124004
77Caffeine metabolism_Homo sapiens_hsa002320.65054007
78Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63906233
79Endocytosis_Homo sapiens_hsa041440.62999420
80Propanoate metabolism_Homo sapiens_hsa006400.62751813
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62573119
82Phototransduction_Homo sapiens_hsa047440.62179293
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61852555
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61502026
85beta-Alanine metabolism_Homo sapiens_hsa004100.61431485
86Dilated cardiomyopathy_Homo sapiens_hsa054140.60156029
87Hematopoietic cell lineage_Homo sapiens_hsa046400.59061480
88Platelet activation_Homo sapiens_hsa046110.58398987
89Pyruvate metabolism_Homo sapiens_hsa006200.57480319
90Fructose and mannose metabolism_Homo sapiens_hsa000510.57308374
91Allograft rejection_Homo sapiens_hsa053300.57132143
92Leukocyte transendothelial migration_Homo sapiens_hsa046700.56700652
93Vitamin B6 metabolism_Homo sapiens_hsa007500.56495575
94Linoleic acid metabolism_Homo sapiens_hsa005910.56394784
95Pertussis_Homo sapiens_hsa051330.55281242
96Collecting duct acid secretion_Homo sapiens_hsa049660.54440493
97Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52986049
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51411139
99Galactose metabolism_Homo sapiens_hsa000520.50994860
100Metabolic pathways_Homo sapiens_hsa011000.50850863
101ECM-receptor interaction_Homo sapiens_hsa045120.50691035
102Systemic lupus erythematosus_Homo sapiens_hsa053220.50041989
103Leishmaniasis_Homo sapiens_hsa051400.49527955
104Renal cell carcinoma_Homo sapiens_hsa052110.49437665
105Chemical carcinogenesis_Homo sapiens_hsa052040.49245192
106Viral myocarditis_Homo sapiens_hsa054160.48756446
107Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.48338448
108Purine metabolism_Homo sapiens_hsa002300.48131903
109N-Glycan biosynthesis_Homo sapiens_hsa005100.47104241
110Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46315062
111Homologous recombination_Homo sapiens_hsa034400.46055895
112Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45296972
113Tuberculosis_Homo sapiens_hsa051520.45063677
114Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45001674
115Glycosaminoglycan degradation_Homo sapiens_hsa005310.44912300
116Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44655316
117Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.44339040
118Vascular smooth muscle contraction_Homo sapiens_hsa042700.44002483
119Non-homologous end-joining_Homo sapiens_hsa034500.43363712
120Arginine and proline metabolism_Homo sapiens_hsa003300.42210936
121Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41278993
122Drug metabolism - other enzymes_Homo sapiens_hsa009830.40997693
123Serotonergic synapse_Homo sapiens_hsa047260.40724439
124Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40588798
125Folate biosynthesis_Homo sapiens_hsa007900.40097213
126Ras signaling pathway_Homo sapiens_hsa040140.37159438
127Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.37120182
128Jak-STAT signaling pathway_Homo sapiens_hsa046300.37060416
129Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36110499
130Tyrosine metabolism_Homo sapiens_hsa003500.36100908
131Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35093467
132Selenocompound metabolism_Homo sapiens_hsa004500.34922163
133Toll-like receptor signaling pathway_Homo sapiens_hsa046200.34478375
134Peroxisome_Homo sapiens_hsa041460.34341527
135PI3K-Akt signaling pathway_Homo sapiens_hsa041510.34176025
136Basal transcription factors_Homo sapiens_hsa030220.33646160
137Measles_Homo sapiens_hsa051620.33493378
138Asthma_Homo sapiens_hsa053100.33439019
139B cell receptor signaling pathway_Homo sapiens_hsa046620.32873973
140Cell cycle_Homo sapiens_hsa041100.32729461
141Phospholipase D signaling pathway_Homo sapiens_hsa040720.32400439
142Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.31370631
143Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30069454
144p53 signaling pathway_Homo sapiens_hsa041150.29686442
145Oocyte meiosis_Homo sapiens_hsa041140.27948609
146Chemokine signaling pathway_Homo sapiens_hsa040620.27812867
147Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.26846420
148Phenylalanine metabolism_Homo sapiens_hsa003600.24037460

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »