SNCA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.86042704
2vocalization behavior (GO:0071625)5.71355085
3synaptic vesicle exocytosis (GO:0016079)5.64075997
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.37128699
5protein localization to synapse (GO:0035418)5.21436251
6regulation of short-term neuronal synaptic plasticity (GO:0048172)5.21433782
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.91783667
8glutamate secretion (GO:0014047)4.82403067
9ionotropic glutamate receptor signaling pathway (GO:0035235)4.77335762
10regulation of glutamate receptor signaling pathway (GO:1900449)4.73686660
11glutamate receptor signaling pathway (GO:0007215)4.66940103
12hepatocyte apoptotic process (GO:0097284)4.64945925
13negative regulation of amyloid precursor protein catabolic process (GO:1902992)4.63236050
14negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.59400327
15negative regulation of cell killing (GO:0031342)4.59400327
16positive regulation of gamma-delta T cell activation (GO:0046645)4.52950654
17neuron recognition (GO:0008038)4.52111774
18regulation of B cell receptor signaling pathway (GO:0050855)4.50554492
19regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.46920504
20regulation of synaptic vesicle exocytosis (GO:2000300)4.43137217
21positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.40919167
22exploration behavior (GO:0035640)4.32279289
23gamma-aminobutyric acid signaling pathway (GO:0007214)4.30001805
24regulation of platelet aggregation (GO:0090330)4.28741752
25response to histamine (GO:0034776)4.25611816
26positive regulation of synapse maturation (GO:0090129)4.24843708
27* neuron-neuron synaptic transmission (GO:0007270)4.21388897
28presynaptic membrane assembly (GO:0097105)4.17046867
29synaptic transmission, glutamatergic (GO:0035249)4.10891153
30protoporphyrinogen IX metabolic process (GO:0046501)4.07770133
31locomotory exploration behavior (GO:0035641)4.02563702
32neuronal action potential propagation (GO:0019227)4.02082259
33regulation of synaptic vesicle transport (GO:1902803)4.01615206
34negative regulation of synaptic transmission, GABAergic (GO:0032229)4.01110604
35neutrophil activation involved in immune response (GO:0002283)3.88196144
36* regulation of long-term neuronal synaptic plasticity (GO:0048169)3.88145546
37neurotransmitter secretion (GO:0007269)3.86183241
38detection of molecule of bacterial origin (GO:0032490)3.86057287
39presynaptic membrane organization (GO:0097090)3.85747995
40axonal fasciculation (GO:0007413)3.83760783
41synaptic vesicle docking involved in exocytosis (GO:0016081)3.83171455
42behavioral fear response (GO:0001662)3.79810030
43behavioral defense response (GO:0002209)3.79810030
44* regulation of excitatory postsynaptic membrane potential (GO:0060079)3.77734019
45positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.74737177
46positive regulation of insulin receptor signaling pathway (GO:0046628)3.74509390
47regulation of beta-amyloid formation (GO:1902003)3.74401292
48antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.74280392
49postsynaptic membrane organization (GO:0001941)3.73920276
50fear response (GO:0042596)3.72907308
51neurotransmitter-gated ion channel clustering (GO:0072578)3.69976285
52protein K11-linked deubiquitination (GO:0035871)3.69753982
53melanin biosynthetic process (GO:0042438)3.69220273
54oxygen transport (GO:0015671)3.63943119
55* regulation of neuronal synaptic plasticity (GO:0048168)3.63023137
56* regulation of postsynaptic membrane potential (GO:0060078)3.62987992
57ATP hydrolysis coupled proton transport (GO:0015991)3.62795800
58energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.62795800
59synaptic vesicle maturation (GO:0016188)3.59669259
60G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.59477696
61melanin metabolic process (GO:0006582)3.58550102
62cerebellar Purkinje cell differentiation (GO:0021702)3.56780644
63neutrophil mediated immunity (GO:0002446)3.56677891
64regulation of dendritic spine morphogenesis (GO:0061001)3.55164981
65positive regulation of granulocyte differentiation (GO:0030854)3.53265445
66regulation of vesicle fusion (GO:0031338)3.53097194
67positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.52286503
68mating behavior (GO:0007617)3.51847980
69long-term memory (GO:0007616)3.50101834
70positive regulation by symbiont of host defense response (GO:0052509)3.48657857
71modulation by symbiont of host defense response (GO:0052031)3.48657857
72modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.48657857
73modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.48657857
74positive regulation by organism of defense response of other organism involved in symbiotic interact3.48657857
75modulation by symbiont of host immune response (GO:0052553)3.48657857
76G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.48460269
77* regulation of synaptic plasticity (GO:0048167)3.48411969
78detection of calcium ion (GO:0005513)3.47594697
79dendritic spine morphogenesis (GO:0060997)3.46577971
80proline transport (GO:0015824)3.45398178
81mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.44415000
82phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.44335008
83* long-term synaptic potentiation (GO:0060291)3.44056521
84myeloid leukocyte mediated immunity (GO:0002444)3.41908403
85positive regulation of membrane potential (GO:0045838)3.41166190
86regulation of synapse maturation (GO:0090128)3.40232340
87response to methylmercury (GO:0051597)3.38519425
88regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.37189805
89transmission of nerve impulse (GO:0019226)3.36257489
90transferrin transport (GO:0033572)3.36170573
91regulation of synapse structural plasticity (GO:0051823)3.35264372
92* microglial cell activation (GO:0001774)3.34691432
93regulation of synaptic transmission, glutamatergic (GO:0051966)3.33834123
94response to amphetamine (GO:0001975)3.31853475
95positive T cell selection (GO:0043368)3.31771615
96* neurotransmitter transport (GO:0006836)3.30989278
97regulation of amyloid precursor protein catabolic process (GO:1902991)3.30408346
98positive regulation of synapse assembly (GO:0051965)3.29512566
99layer formation in cerebral cortex (GO:0021819)3.29386452
100serotonin metabolic process (GO:0042428)3.27022109
101energy coupled proton transport, down electrochemical gradient (GO:0015985)3.22594609
102ATP synthesis coupled proton transport (GO:0015986)3.22594609
103regulation of dendritic spine development (GO:0060998)3.22332213
104myeloid cell development (GO:0061515)3.21181888
105female mating behavior (GO:0060180)3.20180580
106learning (GO:0007612)3.19689786
107regulation of mitochondrial depolarization (GO:0051900)3.18150321
108macrophage activation involved in immune response (GO:0002281)3.17969150
109innervation (GO:0060384)3.16283626
110negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.15614565
111regulation of female receptivity (GO:0045924)3.15337853
112positive regulation of dendritic spine morphogenesis (GO:0061003)3.13385670
113regulation of gamma-delta T cell differentiation (GO:0045586)3.12885541
114* regulation of neurotransmitter levels (GO:0001505)3.10176089
115trivalent inorganic cation transport (GO:0072512)3.09974972
116ferric iron transport (GO:0015682)3.09974972
117* synaptic vesicle endocytosis (GO:0048488)3.09453378
118* establishment of synaptic vesicle localization (GO:0097480)3.09409928
119* synaptic vesicle transport (GO:0048489)3.09409928
120positive regulation of dendritic spine development (GO:0060999)3.08153796
121positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.07978516
122* behavioral response to cocaine (GO:0048148)3.07885768
123intraspecies interaction between organisms (GO:0051703)3.07746164
124social behavior (GO:0035176)3.07746164
125gas transport (GO:0015669)3.04740888
126membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.04334303
127synapse assembly (GO:0007416)3.04137834
128startle response (GO:0001964)3.02318073
129megakaryocyte development (GO:0035855)3.02021142
130* membrane depolarization (GO:0051899)3.01131330
131regulation of gamma-delta T cell activation (GO:0046643)3.00211659
132hemoglobin metabolic process (GO:0020027)2.99454425
133* synaptic transmission (GO:0007268)2.99217178
134* dopamine biosynthetic process (GO:0042416)2.98920621
135mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.98839915
136negative regulation of T cell mediated immunity (GO:0002710)2.98613169
137positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.98006579
138mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.98006579
139regulation of protein kinase A signaling (GO:0010738)2.97982770
140regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.97744128
141negative regulation of amino acid transport (GO:0051956)2.97011186
142* regulation of glutamate secretion (GO:0014048)2.96974117
143cochlea development (GO:0090102)2.96772654
144negative regulation of lymphocyte mediated immunity (GO:0002707)2.96656105
145positive regulation of mast cell activation (GO:0033005)2.96038295
146activated T cell proliferation (GO:0050798)2.95706823
147positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.95450205
148* regulation of neurotransmitter secretion (GO:0046928)2.95347771
149calcium-mediated signaling using intracellular calcium source (GO:0035584)2.94648428
150long term synaptic depression (GO:0060292)2.94444964
151myeloid cell activation involved in immune response (GO:0002275)2.93079261
152B cell receptor signaling pathway (GO:0050853)2.92299059
153response to insecticide (GO:0017085)2.90388601
154positive thymic T cell selection (GO:0045059)2.88929605
155secondary metabolite biosynthetic process (GO:0044550)2.88003805
156cellular extravasation (GO:0045123)2.87884935
157negative T cell selection (GO:0043383)2.85396214
158histone mRNA catabolic process (GO:0071044)2.84153177
159regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.83442275
160erythrocyte development (GO:0048821)2.82641629
161detection of external biotic stimulus (GO:0098581)2.80431685
162neutrophil activation (GO:0042119)2.78663292
163regulation of platelet activation (GO:0010543)2.76760251
164leukocyte migration involved in inflammatory response (GO:0002523)2.76436164
165response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.75483706
166response to host immune response (GO:0052572)2.75483706
167negative regulation of inclusion body assembly (GO:0090084)2.75233602
168* macrophage activation (GO:0042116)2.70118218
169negative thymic T cell selection (GO:0045060)2.68003815
170negative regulation of protein oligomerization (GO:0032460)2.67056074
171nerve growth factor signaling pathway (GO:0038180)2.66746954
172regulation of clathrin-mediated endocytosis (GO:2000369)2.66320018
173negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.65087794
174regulation of necroptotic process (GO:0060544)2.62695098
175leukocyte degranulation (GO:0043299)2.52556377
176negative regulation of B cell mediated immunity (GO:0002713)2.50165179
177negative regulation of immunoglobulin mediated immune response (GO:0002890)2.50165179
178negative regulation of interleukin-17 production (GO:0032700)2.48736180
179regulation of cellular amide metabolic process (GO:0034248)2.47493410
180detection of other organism (GO:0098543)2.45848512
181negative regulation of leukocyte mediated immunity (GO:0002704)2.44724699
182superoxide anion generation (GO:0042554)2.43311291
183clathrin coat assembly (GO:0048268)2.43260500
184negative regulation of B cell proliferation (GO:0030889)2.42599571
185regulation of voltage-gated calcium channel activity (GO:1901385)2.41122719
186granulocyte activation (GO:0036230)2.40494518
187cerebellar granule cell differentiation (GO:0021707)2.40287696

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.37083489
2GBX2_23144817_ChIP-Seq_PC3_Human4.37087210
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.26618965
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.20130787
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.11960023
6SCL_19346495_ChIP-Seq_HPC-7_Human3.01563655
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.98611107
8GATA1_22025678_ChIP-Seq_K562_Human2.96939219
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.84755913
10TAF15_26573619_Chip-Seq_HEK293_Human2.84389409
11* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.79816151
12REST_21632747_ChIP-Seq_MESCs_Mouse2.68762698
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.58671720
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.58392261
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.58392261
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.57727930
17GATA1_19941826_ChIP-Seq_K562_Human2.56683796
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.53944603
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.53857330
20* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.43829857
21MTF2_20144788_ChIP-Seq_MESCs_Mouse2.39653116
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.38264070
23SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.37667313
24* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.37260057
25CTBP1_25329375_ChIP-Seq_LNCAP_Human2.35746733
26CTBP2_25329375_ChIP-Seq_LNCAP_Human2.31775804
27ZFP57_27257070_Chip-Seq_ESCs_Mouse2.25534000
28RARB_27405468_Chip-Seq_BRAIN_Mouse2.19990495
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.17757987
30RUNX_20019798_ChIP-Seq_JUKART_Human2.17331466
31IRF8_21731497_ChIP-ChIP_J774_Mouse2.12501214
32REST_18959480_ChIP-ChIP_MESCs_Mouse2.11519332
33MYB_21317192_ChIP-Seq_ERMYB_Mouse2.11142184
34SUZ12_27294783_Chip-Seq_ESCs_Mouse2.08895697
35GATA2_19941826_ChIP-Seq_K562_Human2.06203340
36GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.05691217
37IRF8_22096565_ChIP-ChIP_GC-B_Human2.01845665
38RNF2_27304074_Chip-Seq_ESCs_Mouse2.00458011
39Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.00406454
40* GATA1_19941827_ChIP-Seq_MEL_Mouse2.00307592
41EZH2_27294783_Chip-Seq_ESCs_Mouse1.99863173
42VDR_22108803_ChIP-Seq_LS180_Human1.99172022
43P300_19829295_ChIP-Seq_ESCs_Human1.93366722
44SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.90755914
45KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.90357785
46SMAD4_21799915_ChIP-Seq_A2780_Human1.89131254
47FUS_26573619_Chip-Seq_HEK293_Human1.88332682
48STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.87732386
49FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.86274116
50IRF8_27001747_Chip-Seq_BMDM_Mouse1.86065555
51BMI1_23680149_ChIP-Seq_NPCS_Mouse1.85112478
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81934788
53DROSHA_22980978_ChIP-Seq_HELA_Human1.80242715
54* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.79064750
55CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.78866551
56AR_21572438_ChIP-Seq_LNCaP_Human1.78645411
57IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.76977019
58* IKZF1_21737484_ChIP-ChIP_HCT116_Human1.75822655
59ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.68311919
60ZNF274_21170338_ChIP-Seq_K562_Hela1.66497495
61TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.65121131
62PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.64611517
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63369428
64* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.63061811
65GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.60115756
66LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.59877419
67SPI1_23127762_ChIP-Seq_K562_Human1.59565240
68* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59326380
69CBX2_27304074_Chip-Seq_ESCs_Mouse1.57219179
70PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.53468778
71* SMAD3_21741376_ChIP-Seq_EPCs_Human1.53443037
72NR3C1_23031785_ChIP-Seq_PC12_Mouse1.53423270
73SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46109809
74RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.45459135
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.44888570
76OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44693088
77PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.43767543
78AR_25329375_ChIP-Seq_VCAP_Human1.42998315
79MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.42460419
80NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.38618122
81UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.38438697
82IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.38291300
83FLI1_27457419_Chip-Seq_LIVER_Mouse1.37268945
84* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37115680
85ERG_21242973_ChIP-ChIP_JURKAT_Human1.35594061
86GATA2_21666600_ChIP-Seq_HMVEC_Human1.31452334
87IGF1R_20145208_ChIP-Seq_DFB_Human1.30675255
88VDR_24787735_ChIP-Seq_THP-1_Human1.30478800
89FLI1_21867929_ChIP-Seq_TH2_Mouse1.29896486
90PRDM14_20953172_ChIP-Seq_ESCs_Human1.29587319
91TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.29439685
92SOX2_21211035_ChIP-Seq_LN229_Gbm1.28639713
93ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.27671608
94RNF2_27304074_Chip-Seq_NSC_Mouse1.25776096
95JUN_21703547_ChIP-Seq_K562_Human1.24209475
96EZH2_27294783_Chip-Seq_NPCs_Mouse1.21825754
97* GATA1_19941827_ChIP-Seq_MEL86_Mouse1.21690865
98RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.21101735
99VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.20631716
100MYB_26560356_Chip-Seq_TH2_Human1.20314243
101ER_23166858_ChIP-Seq_MCF-7_Human1.19109404
102CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.18158924
103STAT3_23295773_ChIP-Seq_U87_Human1.17034602
104BCAT_22108803_ChIP-Seq_LS180_Human1.15752161
105GATA3_27048872_Chip-Seq_THYMUS_Human1.14717464
106* RUNX2_22187159_ChIP-Seq_PCA_Human1.14158760
107TCF4_23295773_ChIP-Seq_U87_Human1.14072721
108TP53_18474530_ChIP-ChIP_U2OS_Human1.13985895
109RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.13880145
110CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.13194738
111CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13162720
112RING1B_27294783_Chip-Seq_ESCs_Mouse1.12537982
113TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.12210298
114NANOG_18555785_Chip-Seq_ESCs_Mouse1.11184857
115LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.10453844
116CMYC_18555785_Chip-Seq_ESCs_Mouse1.10309975
117SMAD_19615063_ChIP-ChIP_OVARY_Human1.09992729
118* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09511128
119P53_22387025_ChIP-Seq_ESCs_Mouse1.09167441
120TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08554221
121RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08070957
122MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07265554
123POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05565859
124TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05565859
125OCT4_21477851_ChIP-Seq_ESCs_Mouse1.05212829
126SMRT_27268052_Chip-Seq_Bcells_Human1.05104090
127NFE2_27457419_Chip-Seq_LIVER_Mouse1.05001806
128PU_27001747_Chip-Seq_BMDM_Mouse1.04941871
129TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04266867
130SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02915914
131EWS_26573619_Chip-Seq_HEK293_Human1.02652134
132BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.02068702
133MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01345465
134SALL4_22934838_ChIP-ChIP_CD34+_Human1.01176697
135SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01143483
136GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00891557
137NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.00804649
138FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.00054138
139ARNT_22903824_ChIP-Seq_MCF-7_Human0.99780815
140AR_19668381_ChIP-Seq_PC3_Human0.99485162
141KDM2B_26808549_Chip-Seq_REH_Human0.99146797
142P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99119585
143GATA3_26560356_Chip-Seq_TH2_Human0.97124873
144CRX_20693478_ChIP-Seq_RETINA_Mouse0.97045082
145SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.97012420
146FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95860707
147NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95856226
148EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.95811759
149CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95737544
150* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.95278048
151EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94198855
152* TP53_16413492_ChIP-PET_HCT116_Human0.94109791
153PCGF2_27294783_Chip-Seq_ESCs_Mouse0.93683498
154* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92530674
155GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91837882
156SOX9_26525672_Chip-Seq_HEART_Mouse0.91132254
157RING1B_27294783_Chip-Seq_NPCs_Mouse0.89807817
158E2F1_18555785_Chip-Seq_ESCs_Mouse0.89524407
159MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88658328

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern6.09566787
2MP0004859_abnormal_synaptic_plasticity5.66816816
3MP0003656_abnormal_erythrocyte_physiolo4.08560574
4* MP0003635_abnormal_synaptic_transmissio4.05383149
5MP0008260_abnormal_autophagy3.90674779
6MP0009745_abnormal_behavioral_response3.57537074
7MP0002063_abnormal_learning/memory/cond3.45623095
8MP0004270_analgesia3.20658112
9MP0005464_abnormal_platelet_physiology3.19182216
10MP0001968_abnormal_touch/_nociception3.18477293
11MP0002064_seizures3.14199415
12MP0002572_abnormal_emotion/affect_behav3.00736501
13MP0000372_irregular_coat_pigmentation2.97798399
14MP0002736_abnormal_nociception_after2.97727692
15MP0005075_abnormal_melanosome_morpholog2.84795520
16MP0003724_increased_susceptibility_to2.83807884
17MP0002822_catalepsy2.81998655
18MP0004381_abnormal_hair_follicle2.77475932
19MP0009046_muscle_twitch2.71068703
20MP0005174_abnormal_tail_pigmentation2.67300587
21MP0001501_abnormal_sleep_pattern2.62926533
22MP0001440_abnormal_grooming_behavior2.57319497
23MP0002735_abnormal_chemical_nociception2.56074685
24MP0002272_abnormal_nervous_system2.52863688
25MP0006276_abnormal_autonomic_nervous2.52072905
26MP0001529_abnormal_vocalization2.48210962
27MP0002734_abnormal_mechanical_nocicepti2.39519425
28MP0003172_abnormal_lysosome_physiology2.37472870
29MP0003303_peritoneal_inflammation2.35703877
30MP0001486_abnormal_startle_reflex2.31030020
31* MP0001905_abnormal_dopamine_level2.23710117
32MP0002837_dystrophic_cardiac_calcinosis2.22194592
33MP0005423_abnormal_somatic_nervous2.08553030
34MP0008877_abnormal_DNA_methylation2.06952009
35MP0002733_abnormal_thermal_nociception2.00995965
36MP0003329_amyloid_beta_deposits1.99052384
37MP0000778_abnormal_nervous_system1.98848052
38MP0004147_increased_porphyrin_level1.98370607
39* MP0002067_abnormal_sensory_capabilities1.98314799
40MP0005386_behavior/neurological_phenoty1.97439252
41MP0004924_abnormal_behavior1.97439252
42MP0002184_abnormal_innervation1.92959858
43MP0001970_abnormal_pain_threshold1.92661429
44MP0001984_abnormal_olfaction1.85736672
45MP0005408_hypopigmentation1.83639411
46MP0001835_abnormal_antigen_presentation1.78283819
47MP0002557_abnormal_social/conspecific_i1.72662285
48MP0001188_hyperpigmentation1.71442854
49MP0002095_abnormal_skin_pigmentation1.63138731
50MP0009780_abnormal_chondrocyte_physiolo1.57135220
51MP0002909_abnormal_adrenal_gland1.54748964
52MP0003690_abnormal_glial_cell1.54251407
53* MP0004811_abnormal_neuron_physiology1.48195820
54MP0003879_abnormal_hair_cell1.46039947
55MP0000371_diluted_coat_color1.39992134
56* MP0002066_abnormal_motor_capabilities/c1.35877150
57MP0003121_genomic_imprinting1.33792817
58MP0005646_abnormal_pituitary_gland1.31247671
59MP0000465_gastrointestinal_hemorrhage1.29666983
60* MP0002882_abnormal_neuron_morphology1.29070223
61MP0003122_maternal_imprinting1.28643120
62MP0004883_abnormal_blood_vessel1.28049635
63* MP0000955_abnormal_spinal_cord1.27069925
64MP0005409_darkened_coat_color1.25721618
65MP0008569_lethality_at_weaning1.25150870
66MP0002332_abnormal_exercise_endurance1.24088818
67MP0003787_abnormal_imprinting1.21109319
68MP0001800_abnormal_humoral_immune1.21081249
69MP0002876_abnormal_thyroid_physiology1.20753827
70MP0008872_abnormal_physiological_respon1.20049475
71MP0004130_abnormal_muscle_cell1.17958313
72MP0002398_abnormal_bone_marrow1.17873269
73MP0005397_hematopoietic_system_phenotyp1.17419743
74MP0001545_abnormal_hematopoietic_system1.17419743
75MP0001502_abnormal_circadian_rhythm1.15678573
76MP0004142_abnormal_muscle_tone1.15101963
77MP0003763_abnormal_thymus_physiology1.14089175
78MP0002419_abnormal_innate_immunity1.11380548
79MP0008057_abnormal_DNA_replication1.11266184
80MP0005645_abnormal_hypothalamus_physiol1.11160887
81MP0003183_abnormal_peptide_metabolism1.08507309
82MP0010386_abnormal_urinary_bladder1.08025142
83MP0005394_taste/olfaction_phenotype1.07148425
84MP0005499_abnormal_olfactory_system1.07148425
85MP0003633_abnormal_nervous_system1.05707092
86MP0004858_abnormal_nervous_system1.05581051
87MP0005535_abnormal_body_temperature1.04977090
88MP0005083_abnormal_biliary_tract1.04895924
89* MP0002152_abnormal_brain_morphology1.02919912
90MP0002420_abnormal_adaptive_immunity1.02184784
91MP0001819_abnormal_immune_cell0.99628613
92MP0005671_abnormal_response_to0.99465878
93MP0005167_abnormal_blood-brain_barrier0.99379569
94MP0005000_abnormal_immune_tolerance0.99370254
95MP0004742_abnormal_vestibular_system0.99078914
96MP0004484_altered_response_of0.98942482
97MP0003866_abnormal_defecation0.98868760
98MP0000689_abnormal_spleen_morphology0.96902235
99MP0002723_abnormal_immune_serum0.96893704
100MP0004145_abnormal_muscle_electrophysio0.96658502
101MP0000751_myopathy0.94749977
102MP0003828_pulmonary_edema0.92729767
103* MP0003631_nervous_system_phenotype0.92441119
104MP0001851_eye_inflammation0.91490866
105MP0000604_amyloidosis0.90938651
106MP0005551_abnormal_eye_electrophysiolog0.90759094
107MP0002069_abnormal_eating/drinking_beha0.90125095
108MP0002722_abnormal_immune_system0.89453651
109MP0005310_abnormal_salivary_gland0.89331123
110MP0001963_abnormal_hearing_physiology0.88632728
111MP0002452_abnormal_antigen_presenting0.88061611
112MP0003221_abnormal_cardiomyocyte_apopto0.87685109
113MP0000716_abnormal_immune_system0.86944875
114MP0004085_abnormal_heartbeat0.86014723
115MP0009379_abnormal_foot_pigmentation0.85193504
116* MP0005025_abnormal_response_to0.83334415
117MP0003136_yellow_coat_color0.83013153
118MP0004885_abnormal_endolymph0.81853948
119MP0000013_abnormal_adipose_tissue0.80711192
120MP0000631_abnormal_neuroendocrine_gland0.80613432
121* MP0002229_neurodegeneration0.78138039
122MP0000703_abnormal_thymus_morphology0.78089386
123MP0004215_abnormal_myocardial_fiber0.77728235
124MP0002166_altered_tumor_susceptibility0.77617381
125MP0000920_abnormal_myelination0.77097190
126MP0003436_decreased_susceptibility_to0.76679521
127MP0002429_abnormal_blood_cell0.76213563
128MP0005171_absent_coat_pigmentation0.76029829
129MP0004808_abnormal_hematopoietic_stem0.75880834
130MP0008004_abnormal_stomach_pH0.75824529
131MP0000685_abnormal_immune_system0.75642145
132* MP0002752_abnormal_somatic_nervous0.75058680
133* MP0008874_decreased_physiological_sensi0.73357049
134MP0003300_gastrointestinal_ulcer0.72672435
135* MP0001664_abnormal_digestion0.67395265
136MP0000026_abnormal_inner_ear0.65087756
137MP0005379_endocrine/exocrine_gland_phen0.63053291
138MP0008789_abnormal_olfactory_epithelium0.60365077
139MP0006292_abnormal_olfactory_placode0.57525142
140MP0001177_atelectasis0.57217373
141MP0002102_abnormal_ear_morphology0.56610291
142MP0002090_abnormal_vision0.55714448
143MP0002163_abnormal_gland_morphology0.55528620
144MP0001943_abnormal_respiration0.53856976
145* MP0003632_abnormal_nervous_system0.52954949
146MP0004510_myositis0.52240151
147MP0006035_abnormal_mitochondrial_morpho0.51738863
148MP0003861_abnormal_nervous_system0.51705519
149MP0003938_abnormal_ear_development0.51548472
150MP0001765_abnormal_ion_homeostasis0.51166990
151* MP0003634_abnormal_glial_cell0.49406442
152MP0001485_abnormal_pinna_reflex0.49399935
153MP0006072_abnormal_retinal_apoptosis0.48017988
154MP0000569_abnormal_digit_pigmentation0.47047163
155MP0000015_abnormal_ear_pigmentation0.46941554
156* MP0003956_abnormal_body_size0.45669753
157MP0010770_preweaning_lethality0.45548558

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.78766671
2Parkinsonism with favorable response to dopaminergic medication (HP:0002548)6.40871267
3Focal seizures (HP:0007359)5.64907030
4Myokymia (HP:0002411)5.27107867
5Hyperventilation (HP:0002883)5.16323586
6Atonic seizures (HP:0010819)5.15071501
7Hypochromic microcytic anemia (HP:0004840)5.12414058
8Epileptic encephalopathy (HP:0200134)5.01120919
9Abnormality of the heme biosynthetic pathway (HP:0010472)4.83088148
10Prolonged bleeding time (HP:0003010)4.80891714
11Poikilocytosis (HP:0004447)4.68872976
12Absence seizures (HP:0002121)4.53565081
13Limb dystonia (HP:0002451)4.52205817
14Gingival bleeding (HP:0000225)4.29130041
15Recurrent bacterial skin infections (HP:0005406)4.28737222
16Dialeptic seizures (HP:0011146)4.27929961
17Febrile seizures (HP:0002373)4.20293468
18Generalized tonic-clonic seizures (HP:0002069)3.93122641
19Ocular albinism (HP:0001107)3.93020559
20Slow saccadic eye movements (HP:0000514)3.90845051
21Amblyopia (HP:0000646)3.77529718
22T lymphocytopenia (HP:0005403)3.76902546
23Broad-based gait (HP:0002136)3.72615469
24Epistaxis (HP:0000421)3.69741150
25Recurrent abscess formation (HP:0002722)3.68757142
26Increased mean platelet volume (HP:0011877)3.62907239
27Progressive cerebellar ataxia (HP:0002073)3.62040994
28Acute necrotizing encephalopathy (HP:0006965)3.58752729
29Iris hypopigmentation (HP:0007730)3.57038282
30Abnormal platelet volume (HP:0011876)3.55761991
31Aplasia/Hypoplasia of the macula (HP:0008059)3.54820515
32* Visual hallucinations (HP:0002367)3.47012273
33Abnormality of T cell number (HP:0011839)3.43743866
34Microcytic anemia (HP:0001935)3.38815659
35Aplasia/Hypoplasia affecting the retina (HP:0008061)3.26615510
36Abnormal mitochondria in muscle tissue (HP:0008316)3.24248356
37Progressive macrocephaly (HP:0004481)3.23066184
38Spontaneous hematomas (HP:0007420)3.18928310
39Menorrhagia (HP:0000132)3.15949848
40Eczematoid dermatitis (HP:0000976)3.12256851
41Drooling (HP:0002307)3.09560491
42Excessive salivation (HP:0003781)3.09560491
43Anxiety (HP:0000739)3.08957547
44Truncal ataxia (HP:0002078)3.01184031
45Supranuclear gaze palsy (HP:0000605)2.98640838
46Poor eye contact (HP:0000817)2.94524138
47Neurofibrillary tangles (HP:0002185)2.92470248
48Epileptiform EEG discharges (HP:0011182)2.91328768
49Gastrointestinal infarctions (HP:0005244)2.90884333
50Conjunctival telangiectasia (HP:0000524)2.88353505
51Mitochondrial inheritance (HP:0001427)2.86767572
52Progressive inability to walk (HP:0002505)2.85408495
53Acanthocytosis (HP:0001927)2.84241495
54Petechiae (HP:0000967)2.82633362
55Inability to walk (HP:0002540)2.80454030
56Diplopia (HP:0000651)2.79026623
57Abnormality of binocular vision (HP:0011514)2.79026623
58Generalized hypopigmentation (HP:0007513)2.77214943
59Optic neuritis (HP:0100653)2.75547482
60Retrobulbar optic neuritis (HP:0100654)2.75547482
61Pheochromocytoma (HP:0002666)2.75276224
62Hemiplegia (HP:0002301)2.73905343
63Papillary thyroid carcinoma (HP:0002895)2.73425156
64Abnormality of the vasculature of the conjunctiva (HP:0008054)2.71414347
65Acute encephalopathy (HP:0006846)2.70731516
66Hypochromic anemia (HP:0001931)2.70414600
67Gaze-evoked nystagmus (HP:0000640)2.68054523
68EEG with generalized epileptiform discharges (HP:0011198)2.66204690
69Stomatitis (HP:0010280)2.65145142
70Papilledema (HP:0001085)2.65087344
71Gait imbalance (HP:0002141)2.60454719
72Absent speech (HP:0001344)2.59960236
73Depression (HP:0000716)2.59745562
74Neuroendocrine neoplasm (HP:0100634)2.57594748
75Impaired social interactions (HP:0000735)2.57074011
76Abnormal social behavior (HP:0012433)2.57074011
77Impaired vibration sensation in the lower limbs (HP:0002166)2.55360515
78Resting tremor (HP:0002322)2.54822041
79Recurrent fungal infections (HP:0002841)2.54126886
80Insidious onset (HP:0003587)2.50838532
81Termporal pattern (HP:0011008)2.50838532
82Protruding tongue (HP:0010808)2.49930224
83Dysmetria (HP:0001310)2.49432080
84Myositis (HP:0100614)2.46483596
85Recurrent skin infections (HP:0001581)2.44314108
86Orchitis (HP:0100796)2.43247918
87Cholelithiasis (HP:0001081)2.42038553
88Hypsarrhythmia (HP:0002521)2.41546826
89Gingivitis (HP:0000230)2.40452505
90Arterial thrombosis (HP:0004420)2.37797643
91Increased CSF lactate (HP:0002490)2.35407349
92Bradykinesia (HP:0002067)2.35257149
93Purpura (HP:0000979)2.33944968
94Action tremor (HP:0002345)2.33303599
95Dysdiadochokinesis (HP:0002075)2.32154479
96Chest pain (HP:0100749)2.30636224
97Medial flaring of the eyebrow (HP:0010747)2.30359192
98Hemiparesis (HP:0001269)2.28866212
99Abnormality of saccadic eye movements (HP:0000570)2.27231679
100Congenital primary aphakia (HP:0007707)2.24506096
101Abnormal eating behavior (HP:0100738)2.23910310
102Leukocytosis (HP:0001974)2.21213454
103Polycythemia (HP:0001901)2.20602509
104Optic disc pallor (HP:0000543)2.19431877
105Abnormal gallbladder morphology (HP:0012437)2.18404879
106Polyphagia (HP:0002591)2.18008257
107Keratoconjunctivitis sicca (HP:0001097)2.17308710
108Generalized myoclonic seizures (HP:0002123)2.15693116
109* Cerebral inclusion bodies (HP:0100314)2.15257358
110Psychosis (HP:0000709)2.15175782
111Abnormality of salivation (HP:0100755)2.14098071
112Recurrent gram-negative bacterial infections (HP:0005420)2.13262734
113Urinary bladder sphincter dysfunction (HP:0002839)2.13033440
114Hypothermia (HP:0002045)2.12710322
115Encephalitis (HP:0002383)2.11654266
116Subacute progressive viral hepatitis (HP:0006572)2.11540760
117Abnormality of the corticospinal tract (HP:0002492)2.11337878
118Impaired smooth pursuit (HP:0007772)2.10916413
119Fetal akinesia sequence (HP:0001989)2.10481218
120Retinal dysplasia (HP:0007973)2.07709086
121Elevated erythrocyte sedimentation rate (HP:0003565)2.07650383
122Nephrogenic diabetes insipidus (HP:0009806)2.07209986
123Mutism (HP:0002300)2.06684344
124Peritonitis (HP:0002586)2.04192316
125Urticaria (HP:0001025)2.03569565
126Hypoventilation (HP:0002791)2.02166772
127Blue irides (HP:0000635)2.01655314
128Genital tract atresia (HP:0001827)2.00241066
129* Delusions (HP:0000746)2.00064587
130Abnormal gallbladder physiology (HP:0012438)1.98751942
131Cholecystitis (HP:0001082)1.98751942
132Keratoconjunctivitis (HP:0001096)1.98695489
133Degeneration of the lateral corticospinal tracts (HP:0002314)1.97584213
134Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.97584213
135Vaginal atresia (HP:0000148)1.96909031
136X-linked dominant inheritance (HP:0001423)1.96764922
137Dynein arm defect of respiratory motile cilia (HP:0012255)1.96133694
138Absent/shortened dynein arms (HP:0200106)1.96133694
139Abnormal hair whorl (HP:0010721)1.96017969
140Abnormality of T cells (HP:0002843)1.95940982
141Hepatocellular necrosis (HP:0001404)1.95900458
142Amyotrophic lateral sclerosis (HP:0007354)1.95494931
143Hyperthyroidism (HP:0000836)1.94870201
144Gastroesophageal reflux (HP:0002020)1.93487695
145Stereotypic behavior (HP:0000733)1.92717923
146Thyroid carcinoma (HP:0002890)1.92609350
147Abnormal auditory evoked potentials (HP:0006958)1.90938703
148Episodic fever (HP:0001954)1.90380738
149Abnormality of macrophages (HP:0004311)1.89780491
150Increased hepatocellular lipid droplets (HP:0006565)1.89750896
151Ankle clonus (HP:0011448)1.88560224
152Urinary urgency (HP:0000012)1.88358153
153Abnormality of the lower motor neuron (HP:0002366)1.88164847
154Fair hair (HP:0002286)1.87846173
155Chronic obstructive pulmonary disease (HP:0006510)1.86605987
156Obstructive lung disease (HP:0006536)1.86605987
157Hypoplasia of the fovea (HP:0007750)1.86323949
158Aplasia/Hypoplasia of the fovea (HP:0008060)1.86323949
159Generalized hypopigmentation of hair (HP:0011358)1.85185149
160Gait ataxia (HP:0002066)1.84923292
161Rigidity (HP:0002063)1.84077395
162Vertigo (HP:0002321)1.84003658
163Paresthesia (HP:0003401)1.83999467
164Chronic mucocutaneous candidiasis (HP:0002728)1.83902130
165Recurrent cutaneous fungal infections (HP:0011370)1.83902130
166Spastic gait (HP:0002064)1.83623285
167Genetic anticipation (HP:0003743)1.83346639
168Poor suck (HP:0002033)1.83239443
169Status epilepticus (HP:0002133)1.83106129
170Abnormal ciliary motility (HP:0012262)1.82939114
171Thickened helices (HP:0000391)1.82902241
172Abnormality of ocular smooth pursuit (HP:0000617)1.82321863
173Postural instability (HP:0002172)1.82158990

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.97335662
2NTRK34.10703924
3MAP3K123.76988366
4CASK3.62236752
5MAP3K43.36076993
6RIPK43.29014456
7MAP2K73.15709991
8MAP3K93.02699811
9FRK2.78196489
10PNCK2.70645201
11MINK12.55216506
12BLK2.43131053
13MARK12.40674589
14DAPK22.29719350
15MAP2K42.25456283
16MAP2K32.12533614
17ARAF2.10459440
18DAPK12.07392906
19NME12.00046644
20EIF2AK11.99852784
21TAOK31.89990580
22* SYK1.73498800
23BMPR21.70224739
24CDK191.68896910
25IKBKE1.66514556
26KSR11.66125141
27STK41.62395293
28KSR21.61405739
29SGK31.55929572
30SIK21.55747242
31WNK11.51868255
32ERBB21.50108340
33CSK1.49900795
34MAP3K111.44725359
35TEC1.44164683
36NTRK21.43342723
37MARK31.42236497
38TAOK11.42151511
39BTK1.39622389
40CDK51.38484318
41MAP3K131.35076860
42MAPK131.33385917
43NTRK11.32143845
44* CAMK2A1.29631827
45CAMK2B1.27332570
46* PLK21.27116528
47FES1.26076907
48PRKCG1.25417009
49PAK61.23410944
50TXK1.22450751
51PIK3CG1.21129445
52IRAK41.18506250
53IRAK21.14830715
54PIM11.12986197
55TNIK1.12024174
56MARK21.10748349
57HCK1.10456008
58ACVR1B1.08108117
59MAPKAPK51.07618015
60FGFR31.06899812
61YES11.06188309
62OXSR11.04278171
63ZAP701.03910698
64JAK21.02167583
65MAP3K31.00543543
66MAP3K50.99924549
67JAK30.98723300
68GRK70.97948452
69RAF10.97273316
70CSNK1G20.96607698
71CDK180.94460950
72PRPF4B0.93749544
73CDK140.93680909
74JAK10.92907503
75CDK150.89683531
76* LYN0.87603520
77BMX0.86963487
78ITK0.84581532
79PINK10.84496265
80CAMKK20.83015859
81MAP4K10.81584165
82CAMK2D0.81242980
83ADRBK20.80300493
84CDK11A0.79454118
85IRAK10.78474135
86CAMKK10.78289022
87MAP3K60.77934595
88LATS20.73425735
89MATK0.72791564
90UHMK10.71606872
91PRKCH0.70728376
92CCNB10.69840004
93PRKCE0.68806900
94SIK30.66909047
95CAMK40.65138599
96BRAF0.65135374
97CSNK1G30.64088861
98FER0.63618639
99AKT30.63320639
100LCK0.62343084
101NEK60.60541054
102MAP3K20.59506867
103SGK10.59097224
104BCR0.59034401
105CAMK2G0.59028593
106TYK20.58484386
107RET0.58095515
108CAMK10.57082085
109PHKG10.56487113
110PHKG20.56487113
111EGFR0.56020390
112PAK30.55955557
113* GRK50.55866596
114MYLK0.55811488
115* FYN0.55438768
116ROCK20.55224225
117TAOK20.54901545
118FGFR20.54824362
119SGK2230.54019906
120SGK4940.54019906
121MAP2K10.53655870
122STK110.51935095
123DAPK30.51771241
124STK380.50161719
125MAP3K140.50103637
126TYRO30.48889033
127PRKD10.48770840
128MAPK120.47296540
129MUSK0.47206297
130CSF1R0.47059199
131PRKCZ0.45204805
132MOS0.44844383
133* PTK2B0.43600360
134PRKACA0.40794655
135BMPR1B0.38343141
136IKBKB0.38172600
137STK390.37533999
138PDK40.36558337
139PDK30.36558337
140PDPK10.35245406
141MAP3K10.34946715
142TSSK60.34775045
143WNK30.34670955
144SGK20.32187831
145PRKCB0.31684977
146PRKCQ0.30770673
147RPS6KA30.30319349
148WNK40.29947842
149PRKD30.29889635
150PRKCA0.29442007
151TNK20.29421783
152PDK10.29328058
153* DYRK1A0.29206339
154PKN10.28117647

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.14967546
2Synaptic vesicle cycle_Homo sapiens_hsa047213.43304121
3Collecting duct acid secretion_Homo sapiens_hsa049662.96711091
4Long-term potentiation_Homo sapiens_hsa047202.92037676
5Amphetamine addiction_Homo sapiens_hsa050312.91666563
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.87901552
7Oxidative phosphorylation_Homo sapiens_hsa001902.66709185
8Olfactory transduction_Homo sapiens_hsa047402.58803995
9Circadian entrainment_Homo sapiens_hsa047132.54229364
10Glutamatergic synapse_Homo sapiens_hsa047242.43187086
11GABAergic synapse_Homo sapiens_hsa047272.43161774
12Dopaminergic synapse_Homo sapiens_hsa047282.41056131
13Morphine addiction_Homo sapiens_hsa050322.40547622
14Platelet activation_Homo sapiens_hsa046112.15813767
15Taste transduction_Homo sapiens_hsa047422.11801475
16Salivary secretion_Homo sapiens_hsa049702.10836440
17Serotonergic synapse_Homo sapiens_hsa047262.05130530
18Parkinsons disease_Homo sapiens_hsa050122.02206436
19Alzheimers disease_Homo sapiens_hsa050101.98709792
20Renin secretion_Homo sapiens_hsa049241.98269722
21Cocaine addiction_Homo sapiens_hsa050301.86172730
22Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.83013317
23B cell receptor signaling pathway_Homo sapiens_hsa046621.76823308
24Long-term depression_Homo sapiens_hsa047301.75095853
25Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.73542286
26Calcium signaling pathway_Homo sapiens_hsa040201.71206206
27Cholinergic synapse_Homo sapiens_hsa047251.69534466
28Gastric acid secretion_Homo sapiens_hsa049711.69166036
29Vibrio cholerae infection_Homo sapiens_hsa051101.68804452
30Insulin secretion_Homo sapiens_hsa049111.64878826
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.57340500
32Osteoclast differentiation_Homo sapiens_hsa043801.56827065
33Cardiac muscle contraction_Homo sapiens_hsa042601.55926877
34Oxytocin signaling pathway_Homo sapiens_hsa049211.55530419
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.51536966
36Leishmaniasis_Homo sapiens_hsa051401.47310626
37Huntingtons disease_Homo sapiens_hsa050161.42837063
38Chemokine signaling pathway_Homo sapiens_hsa040621.38979911
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.37748262
40Malaria_Homo sapiens_hsa051441.37439475
41Tuberculosis_Homo sapiens_hsa051521.35973922
42T cell receptor signaling pathway_Homo sapiens_hsa046601.34036588
43Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.33647987
44GnRH signaling pathway_Homo sapiens_hsa049121.33051712
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.31665804
46Gap junction_Homo sapiens_hsa045401.30268679
47Phototransduction_Homo sapiens_hsa047441.29187301
48NOD-like receptor signaling pathway_Homo sapiens_hsa046211.26438162
49Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.21882276
50Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.18842640
51Toll-like receptor signaling pathway_Homo sapiens_hsa046201.10477577
52cAMP signaling pathway_Homo sapiens_hsa040241.04708708
53Axon guidance_Homo sapiens_hsa043601.03717333
54Endometrial cancer_Homo sapiens_hsa052131.01321290
55FoxO signaling pathway_Homo sapiens_hsa040680.99321713
56Estrogen signaling pathway_Homo sapiens_hsa049150.97486433
57Hematopoietic cell lineage_Homo sapiens_hsa046400.97396720
58Melanogenesis_Homo sapiens_hsa049160.95856293
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.94246007
60Regulation of autophagy_Homo sapiens_hsa041400.93838402
61cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93535901
62Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93462638
63Phosphatidylinositol signaling system_Homo sapiens_hsa040700.92661191
64Pancreatic cancer_Homo sapiens_hsa052120.91261530
65Glioma_Homo sapiens_hsa052140.89057076
66Prolactin signaling pathway_Homo sapiens_hsa049170.88210229
67Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.87666538
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.85043371
69Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.84852289
70Oocyte meiosis_Homo sapiens_hsa041140.83684179
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83482320
72mTOR signaling pathway_Homo sapiens_hsa041500.82986747
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82569755
74Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.80802858
75Jak-STAT signaling pathway_Homo sapiens_hsa046300.78158950
76Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.76712525
77Alcoholism_Homo sapiens_hsa050340.75208819
78Rheumatoid arthritis_Homo sapiens_hsa053230.74927356
79NF-kappa B signaling pathway_Homo sapiens_hsa040640.73685513
80Measles_Homo sapiens_hsa051620.72981249
81African trypanosomiasis_Homo sapiens_hsa051430.72756292
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71452634
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.71077613
84Endocytosis_Homo sapiens_hsa041440.71023722
85RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.70202173
86ErbB signaling pathway_Homo sapiens_hsa040120.69358829
87Hepatitis B_Homo sapiens_hsa051610.67261985
88Pancreatic secretion_Homo sapiens_hsa049720.67222091
89Toxoplasmosis_Homo sapiens_hsa051450.66641938
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.66617043
91Acute myeloid leukemia_Homo sapiens_hsa052210.65551696
92Legionellosis_Homo sapiens_hsa051340.64794827
93Staphylococcus aureus infection_Homo sapiens_hsa051500.63616506
94Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.62811346
95Apoptosis_Homo sapiens_hsa042100.62306134
96Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.61639218
97Glucagon signaling pathway_Homo sapiens_hsa049220.59983616
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59770050
99Chronic myeloid leukemia_Homo sapiens_hsa052200.59031983
100Type II diabetes mellitus_Homo sapiens_hsa049300.58912123
101HIF-1 signaling pathway_Homo sapiens_hsa040660.57671942
102Nitrogen metabolism_Homo sapiens_hsa009100.55746885
103Thyroid hormone synthesis_Homo sapiens_hsa049180.54328136
104Choline metabolism in cancer_Homo sapiens_hsa052310.51141661
105Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.49003713
106Dorso-ventral axis formation_Homo sapiens_hsa043200.48574868
107VEGF signaling pathway_Homo sapiens_hsa043700.48251382
108MAPK signaling pathway_Homo sapiens_hsa040100.47677268
109Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.46715272
110Phagosome_Homo sapiens_hsa041450.44034565
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.42973380
112Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42833809
113Ras signaling pathway_Homo sapiens_hsa040140.42509861
114Dilated cardiomyopathy_Homo sapiens_hsa054140.42313756
115Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41635850
116Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40387815
117Rap1 signaling pathway_Homo sapiens_hsa040150.34072896
118Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33255064
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.32358300
120Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32034866
121Prion diseases_Homo sapiens_hsa050200.30195613
122Pyruvate metabolism_Homo sapiens_hsa006200.30004460
123Inositol phosphate metabolism_Homo sapiens_hsa005620.29238790
124Type I diabetes mellitus_Homo sapiens_hsa049400.29221758
125Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.27992801
126Neurotrophin signaling pathway_Homo sapiens_hsa047220.27835705
127Wnt signaling pathway_Homo sapiens_hsa043100.25483422
128Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.21981217
129Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.20632062
130Renal cell carcinoma_Homo sapiens_hsa052110.17277142
131Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.13773778
132Insulin signaling pathway_Homo sapiens_hsa049100.12529694
133SNARE interactions in vesicular transport_Homo sapiens_hsa041300.12457432
134Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.12113356
135Circadian rhythm_Homo sapiens_hsa047100.11453516
136Tyrosine metabolism_Homo sapiens_hsa003500.11373807
137Carbohydrate digestion and absorption_Homo sapiens_hsa049730.11043650
138Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.10995518
139Phenylalanine metabolism_Homo sapiens_hsa003600.10097689
140Non-small cell lung cancer_Homo sapiens_hsa052230.07958023

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