SNCAIP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing several protein-protein interaction domains, including ankyrin-like repeats, a coiled-coil domain, and an ATP/GTP-binding motif. The encoded protein interacts with alpha-synuclein in neuronal tissue and may play a role in the formation of cytoplasmic inclusions and neurodegeneration. A mutation in this gene has been associated with Parkinson's disease. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)5.61258896
2glomerulus development (GO:0032835)5.51643925
3presynaptic membrane organization (GO:0097090)4.98286852
4metanephric mesenchyme development (GO:0072075)4.74412311
5postsynaptic membrane organization (GO:0001941)4.71997946
6mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)4.55390177
7epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.43110470
8kidney mesenchyme development (GO:0072074)4.41470759
9head development (GO:0060322)4.28693973
10epithelial cilium movement (GO:0003351)4.24174995
11neuron cell-cell adhesion (GO:0007158)4.22111840
12pyrimidine nucleobase catabolic process (GO:0006208)4.18694245
13negative regulation of axon extension involved in axon guidance (GO:0048843)4.12919682
14cerebral cortex radially oriented cell migration (GO:0021799)4.08943275
15negative regulation of axon guidance (GO:1902668)4.05027993
16respiratory tube development (GO:0030323)4.04994681
17outer ear morphogenesis (GO:0042473)4.04607159
18negative regulation of oligodendrocyte differentiation (GO:0048715)3.95801948
19mesenchymal cell differentiation involved in renal system development (GO:2001012)3.94705042
20mesenchymal cell differentiation involved in kidney development (GO:0072161)3.94705042
21cilium movement (GO:0003341)3.91010435
22forebrain neuron differentiation (GO:0021879)3.88995657
23auditory behavior (GO:0031223)3.86888458
24nonmotile primary cilium assembly (GO:0035058)3.86842336
25metanephric epithelium development (GO:0072207)3.84038606
26cell differentiation involved in kidney development (GO:0061005)3.78283642
27central nervous system projection neuron axonogenesis (GO:0021952)3.76195954
28proximal/distal pattern formation (GO:0009954)3.71228997
29regulation of development, heterochronic (GO:0040034)3.62329253
30retinal ganglion cell axon guidance (GO:0031290)3.61980696
31limb bud formation (GO:0060174)3.61561332
32mesonephros development (GO:0001823)3.60487293
33glial cell proliferation (GO:0014009)3.58869919
34neuron recognition (GO:0008038)3.55164456
35cell differentiation involved in metanephros development (GO:0072202)3.54478138
36skeletal muscle organ development (GO:0060538)3.52038285
37intraciliary transport (GO:0042073)3.51957538
38mechanosensory behavior (GO:0007638)3.51619201
39axonemal dynein complex assembly (GO:0070286)3.50532300
40response to auditory stimulus (GO:0010996)3.49008731
41regulation of cilium movement (GO:0003352)3.46920460
42facial nerve structural organization (GO:0021612)3.43884108
43axonal fasciculation (GO:0007413)3.43328003
44glomerular basement membrane development (GO:0032836)3.42898733
45mesenchymal to epithelial transition (GO:0060231)3.42422860
46otic vesicle formation (GO:0030916)3.42309198
47diaphragm development (GO:0060539)3.42187486
48layer formation in cerebral cortex (GO:0021819)3.39994430
49metanephric nephron tubule development (GO:0072234)3.39194661
50metanephric tubule development (GO:0072170)3.39194661
51cytoplasmic mRNA processing body assembly (GO:0033962)3.39087570
52negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.37937977
53cilium morphogenesis (GO:0060271)3.36644173
54regulation of axon guidance (GO:1902667)3.35748650
55cellular response to cholesterol (GO:0071397)3.34261427
56hippocampus development (GO:0021766)3.32697023
57regulation of axon extension involved in axon guidance (GO:0048841)3.31246418
58cilium or flagellum-dependent cell motility (GO:0001539)3.30744517
59positive regulation of gastrulation (GO:2000543)3.29705083
60lymph vessel development (GO:0001945)3.28742460
61cell proliferation in forebrain (GO:0021846)3.20741754
62negative regulation of cytosolic calcium ion concentration (GO:0051481)3.19392999
63axon extension involved in axon guidance (GO:0048846)3.19346373
64neuron projection extension involved in neuron projection guidance (GO:1902284)3.19346373
65olfactory bulb development (GO:0021772)3.18457886
66lateral sprouting from an epithelium (GO:0060601)3.17144976
67negative regulation of astrocyte differentiation (GO:0048712)3.17077079
68cilium organization (GO:0044782)3.16125484
69negative regulation of smoothened signaling pathway (GO:0045879)3.15305291
70cilium assembly (GO:0042384)3.13857726
71metanephric nephron epithelium development (GO:0072243)3.11270316
72cranial nerve morphogenesis (GO:0021602)3.11192452
73regulation of mesenchymal cell apoptotic process (GO:2001053)3.10927326
74vocalization behavior (GO:0071625)3.10405010
75epithelial cell differentiation involved in kidney development (GO:0035850)3.10387792
76neural tube formation (GO:0001841)3.09293606
77cranial nerve structural organization (GO:0021604)3.09282003
78retinal rod cell development (GO:0046548)3.08813579
79negative regulation of transcription regulatory region DNA binding (GO:2000678)3.08039019
80nucleobase catabolic process (GO:0046113)3.05960286
81cell migration in hindbrain (GO:0021535)3.05093007
82mesenchyme morphogenesis (GO:0072132)3.03300084
83central nervous system myelination (GO:0022010)3.03061916
84axon ensheathment in central nervous system (GO:0032291)3.03061916
85branching involved in ureteric bud morphogenesis (GO:0001658)3.00426684
86cerebral cortex cell migration (GO:0021795)2.97306059
87regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.96852892
88positive regulation of synapse assembly (GO:0051965)2.95275889
89urogenital system development (GO:0001655)2.94655654
90cellular response to sterol (GO:0036315)2.94038362
91cell proliferation involved in metanephros development (GO:0072203)2.93651843
92Notch signaling involved in heart development (GO:0061314)2.92526504
93transmission of nerve impulse (GO:0019226)2.91233368
94somite development (GO:0061053)2.89726942
95behavioral response to ethanol (GO:0048149)2.88972304
96planar cell polarity pathway involved in neural tube closure (GO:0090179)2.85637170
97positive regulation of mesonephros development (GO:0061213)2.85137637
98regulation of oligodendrocyte differentiation (GO:0048713)2.84828572
99spinal cord development (GO:0021510)2.84581428
100paraxial mesoderm development (GO:0048339)2.84267795
101establishment of mitochondrion localization (GO:0051654)2.84046012
102C4-dicarboxylate transport (GO:0015740)2.83675966
103protein polyglutamylation (GO:0018095)2.81915957
104cochlea morphogenesis (GO:0090103)2.80785772
105cell proliferation involved in kidney development (GO:0072111)2.79592045
106smoothened signaling pathway (GO:0007224)2.78267720
107neurotransmitter-gated ion channel clustering (GO:0072578)2.77491461
108cerebral cortex neuron differentiation (GO:0021895)2.77072212
109negative chemotaxis (GO:0050919)2.76913925
110negative regulation of axon extension (GO:0030517)2.75314917
111axoneme assembly (GO:0035082)2.75003987
112gamma-aminobutyric acid transport (GO:0015812)2.74486926
113behavioral response to nicotine (GO:0035095)2.74135382
114regulation of neurotransmitter uptake (GO:0051580)2.73405469
115embryonic retina morphogenesis in camera-type eye (GO:0060059)2.72610221
116positive regulation of oligodendrocyte differentiation (GO:0048714)2.72360495
117metanephros development (GO:0001656)2.71370324
118synapse assembly (GO:0007416)2.70552204
119regulation of mesonephros development (GO:0061217)2.69357996
120protein localization to synapse (GO:0035418)2.68140187
121negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.67733263
122nephron tubule development (GO:0072080)2.67643752
123regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.67558661
124endocardial cushion morphogenesis (GO:0003203)2.67482317
125sympathetic nervous system development (GO:0048485)2.67110665
126G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.66927193
127anatomical structure arrangement (GO:0048532)2.65224035
128tongue development (GO:0043586)2.64904506
129regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.64071323
130ganglion development (GO:0061548)2.63069989
131detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.61251587
132oligodendrocyte differentiation (GO:0048709)2.58663418
133central nervous system neuron axonogenesis (GO:0021955)2.58304209
134negative regulation of neurotransmitter transport (GO:0051589)2.58202384
135heart valve formation (GO:0003188)2.58001114
136embryonic skeletal joint morphogenesis (GO:0060272)2.57235765
137inner ear receptor stereocilium organization (GO:0060122)2.57139797
138G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.56765326
139neuronal action potential propagation (GO:0019227)2.56446673
140negative regulation of chemotaxis (GO:0050922)2.56067765
141axon extension (GO:0048675)2.55355012
142hippo signaling (GO:0035329)2.55259533
143retinal cone cell development (GO:0046549)2.54936521
144regulation of glomerulus development (GO:0090192)2.54531657
145platelet dense granule organization (GO:0060155)2.54069646
146regulation of NFAT protein import into nucleus (GO:0051532)2.53562760
147regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.53488648
148limb development (GO:0060173)2.53366788
149appendage development (GO:0048736)2.53366788
150regulation of microtubule-based movement (GO:0060632)2.53262761
151atrial cardiac muscle cell action potential (GO:0086014)2.53022177
152enteric nervous system development (GO:0048484)2.52066197
153positive regulation of male gonad development (GO:2000020)2.51966469
154calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.51277153
155neuron fate determination (GO:0048664)2.50833122
156lung morphogenesis (GO:0060425)2.50167681
157embryonic digestive tract development (GO:0048566)2.50124517
158response to pheromone (GO:0019236)2.49834883
159photoreceptor cell development (GO:0042461)2.49810755
160mesenchymal cell differentiation (GO:0048762)2.49804315
161embryonic cranial skeleton morphogenesis (GO:0048701)2.48736316
162cellular component assembly involved in morphogenesis (GO:0010927)2.48400881
163chondrocyte proliferation (GO:0035988)2.47710287
164regulation of synapse structural plasticity (GO:0051823)2.47384992
165negative regulation of glial cell differentiation (GO:0045686)2.47081224
166vascular smooth muscle contraction (GO:0014829)2.46563276
167negative regulation of protein localization to cell surface (GO:2000009)2.45384793
168positive regulation of metanephros development (GO:0072216)2.45090553
169neuronal stem cell maintenance (GO:0097150)2.44917804
170regulation of timing of cell differentiation (GO:0048505)2.44478870
171dendritic spine morphogenesis (GO:0060997)2.44403679
172regulation of collateral sprouting (GO:0048670)2.44207874
173positive regulation of Notch signaling pathway (GO:0045747)2.43267821
174photoreceptor cell maintenance (GO:0045494)2.41740702
175protein localization to cilium (GO:0061512)2.41208397
176auditory receptor cell differentiation (GO:0042491)2.39541524
177hindbrain development (GO:0030902)2.37877783

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.01282628
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.14504882
3CBX2_27304074_Chip-Seq_ESCs_Mouse2.95725327
4EED_16625203_ChIP-ChIP_MESCs_Mouse2.92039003
5EZH2_27304074_Chip-Seq_ESCs_Mouse2.91876531
6PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.86003145
7* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.66591028
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.61851023
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.61851023
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.59691624
11IGF1R_20145208_ChIP-Seq_DFB_Human2.56228601
12GBX2_23144817_ChIP-Seq_PC3_Human2.56169831
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.46772648
14* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.44187796
15* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.42367443
16* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.42119576
17RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.41319824
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.36910453
19RNF2_27304074_Chip-Seq_ESCs_Mouse2.28579144
20* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.26847290
21VDR_22108803_ChIP-Seq_LS180_Human2.25697698
22* EZH2_27294783_Chip-Seq_ESCs_Mouse2.23337889
23RBPJ_22232070_ChIP-Seq_NCS_Mouse2.23329667
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.19135114
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.12720860
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.10789098
27* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.05618816
28POU5F1_16153702_ChIP-ChIP_HESCs_Human2.05304478
29* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.94516479
30SALL1_21062744_ChIP-ChIP_HESCs_Human1.91711709
31* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.89148462
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.86979680
33RNF2_27304074_Chip-Seq_NSC_Mouse1.80687038
34AR_21572438_ChIP-Seq_LNCaP_Human1.78201670
35RING1B_27294783_Chip-Seq_NPCs_Mouse1.74529730
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.72235279
37* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.70859858
38RING1B_27294783_Chip-Seq_ESCs_Mouse1.67806792
39MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.64904431
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.61814912
41* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.60264527
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.59392342
43TP53_20018659_ChIP-ChIP_R1E_Mouse1.58760875
44WT1_19549856_ChIP-ChIP_CCG9911_Human1.56190164
45CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.51798541
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.51515536
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.49349667
48ISL1_27105846_Chip-Seq_CPCs_Mouse1.48777153
49BMI1_23680149_ChIP-Seq_NPCS_Mouse1.46804983
50* P300_19829295_ChIP-Seq_ESCs_Human1.45452125
51ARNT_22903824_ChIP-Seq_MCF-7_Human1.42522413
52TP63_19390658_ChIP-ChIP_HaCaT_Human1.41118309
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40002341
54STAT3_23295773_ChIP-Seq_U87_Human1.40001409
55ER_23166858_ChIP-Seq_MCF-7_Human1.39426147
56HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.38224074
57WT1_25993318_ChIP-Seq_PODOCYTE_Human1.36694593
58DROSHA_22980978_ChIP-Seq_HELA_Human1.36326220
59FLI1_27457419_Chip-Seq_LIVER_Mouse1.34465770
60ZNF274_21170338_ChIP-Seq_K562_Hela1.34274131
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33950561
62TP53_18474530_ChIP-ChIP_U2OS_Human1.30867456
63TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30704304
64RUNX2_22187159_ChIP-Seq_PCA_Human1.30546935
65DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.30070104
66SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29519927
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.29429888
68TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29429888
69KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.29030911
70MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28201187
71AHR_22903824_ChIP-Seq_MCF-7_Human1.27765681
72FUS_26573619_Chip-Seq_HEK293_Human1.27672908
73NANOG_18555785_Chip-Seq_ESCs_Mouse1.26993098
74PCGF2_27294783_Chip-Seq_ESCs_Mouse1.26196474
75ZNF217_24962896_ChIP-Seq_MCF-7_Human1.24780453
76TCF4_23295773_ChIP-Seq_U87_Human1.24731067
77TRIM28_21343339_ChIP-Seq_HEK293_Human1.24412352
78ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.24035529
79YAP1_20516196_ChIP-Seq_MESCs_Mouse1.23777291
80SMAD4_21799915_ChIP-Seq_A2780_Human1.23103062
81* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.22805687
82EWS_26573619_Chip-Seq_HEK293_Human1.21203855
83SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21177364
84* EP300_21415370_ChIP-Seq_HL-1_Mouse1.21081149
85* SOX9_26525672_Chip-Seq_HEART_Mouse1.20999512
86E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.20740598
87CTBP1_25329375_ChIP-Seq_LNCAP_Human1.20652971
88REST_21632747_ChIP-Seq_MESCs_Mouse1.20414109
89TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.18983856
90ZFP281_18757296_ChIP-ChIP_E14_Mouse1.18084825
91TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17936357
92OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.16804893
93TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.15784605
94ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.15712529
95EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15556171
96STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.14552778
97CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13837380
98TAF15_26573619_Chip-Seq_HEK293_Human1.13562392
99NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12660451
100AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12488222
101GATA1_26923725_Chip-Seq_HPCs_Mouse1.12324966
102* TCF4_22108803_ChIP-Seq_LS180_Human1.12284890
103AR_25329375_ChIP-Seq_VCAP_Human1.12181533
104TAL1_26923725_Chip-Seq_HPCs_Mouse1.11239104
105CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.11235044
106TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10900436
107PIAS1_25552417_ChIP-Seq_VCAP_Human1.10451843
108LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09545048
109* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08819110
110SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08431351
111POU3F2_20337985_ChIP-ChIP_501MEL_Human1.06612877
112EZH2_27294783_Chip-Seq_NPCs_Mouse1.05999961
113ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.03863676
114PCGF2_27294783_Chip-Seq_NPCs_Mouse1.03863376
115SMAD3_21741376_ChIP-Seq_ESCs_Human1.03766917
116CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03434176
117AR_19668381_ChIP-Seq_PC3_Human1.03289587
118P53_22387025_ChIP-Seq_ESCs_Mouse1.03206316
119* SOX2_21211035_ChIP-Seq_LN229_Gbm1.02305093
120UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01904520
121* JUN_21703547_ChIP-Seq_K562_Human1.01904235
122RXR_22108803_ChIP-Seq_LS180_Human1.01465188
123P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01262778
124FLI1_21867929_ChIP-Seq_TH2_Mouse1.00415594
125GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00402001
126CBP_20019798_ChIP-Seq_JUKART_Human0.99495608
127IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99495608
128ZFP281_27345836_Chip-Seq_ESCs_Mouse0.99279952
129SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.98852939
130CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.97780020
131MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97729325
132BCAT_22108803_ChIP-Seq_LS180_Human0.97024436

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color3.91590236
2MP0003122_maternal_imprinting3.01001058
3MP0000778_abnormal_nervous_system3.00439306
4MP0003880_abnormal_central_pattern2.95975114
5MP0003942_abnormal_urinary_system2.86199017
6MP0000049_abnormal_middle_ear2.84757613
7MP0003385_abnormal_body_wall2.65213924
8MP0010030_abnormal_orbit_morphology2.62509139
9MP0000534_abnormal_ureter_morphology2.48586654
10MP0002249_abnormal_larynx_morphology2.40312626
11MP0000537_abnormal_urethra_morphology2.38097382
12MP0009053_abnormal_anal_canal2.32905714
13MP0006292_abnormal_olfactory_placode2.32151618
14MP0000566_synostosis2.28681789
15MP0008789_abnormal_olfactory_epithelium2.24288297
16MP0001529_abnormal_vocalization2.19972642
17MP0003115_abnormal_respiratory_system2.19663185
18MP0010368_abnormal_lymphatic_system2.17964053
19MP0003121_genomic_imprinting2.12766879
20MP0009250_abnormal_appendicular_skeleto2.11166480
21MP0002938_white_spotting1.98732068
22MP0004859_abnormal_synaptic_plasticity1.97290528
23MP0001968_abnormal_touch/_nociception1.90559749
24MP0002653_abnormal_ependyma_morphology1.87520519
25MP0002736_abnormal_nociception_after1.87344673
26MP0003755_abnormal_palate_morphology1.84975546
27MP0001879_abnormal_lymphatic_vessel1.83875877
28MP0005503_abnormal_tendon_morphology1.82256348
29MP0005499_abnormal_olfactory_system1.79251496
30MP0005394_taste/olfaction_phenotype1.79251496
31MP0005253_abnormal_eye_physiology1.78106924
32MP0006072_abnormal_retinal_apoptosis1.74891527
33MP0003938_abnormal_ear_development1.74205011
34MP0000516_abnormal_urinary_system1.74192048
35MP0005367_renal/urinary_system_phenotyp1.74192048
36MP0004858_abnormal_nervous_system1.74172610
37MP0002282_abnormal_trachea_morphology1.72285777
38MP0004885_abnormal_endolymph1.68163046
39MP0002184_abnormal_innervation1.66611984
40MP0004133_heterotaxia1.63857895
41MP0005551_abnormal_eye_electrophysiolog1.63785265
42MP0003935_abnormal_craniofacial_develop1.61172407
43MP0003861_abnormal_nervous_system1.58016965
44MP0002116_abnormal_craniofacial_bone1.57825137
45MP0004270_analgesia1.56336079
46MP0002233_abnormal_nose_morphology1.54423820
47MP0001270_distended_abdomen1.49592534
48MP0005248_abnormal_Harderian_gland1.49503975
49MP0003937_abnormal_limbs/digits/tail_de1.48319504
50MP0001485_abnormal_pinna_reflex1.47884216
51MP0002234_abnormal_pharynx_morphology1.47826070
52MP0005423_abnormal_somatic_nervous1.47690782
53MP0004272_abnormal_basement_membrane1.46866500
54MP0009745_abnormal_behavioral_response1.39959714
55MP0000631_abnormal_neuroendocrine_gland1.39063105
56MP0005623_abnormal_meninges_morphology1.38809905
57MP0002735_abnormal_chemical_nociception1.38376743
58MP0002272_abnormal_nervous_system1.32570530
59MP0002734_abnormal_mechanical_nocicepti1.30406285
60MP0001984_abnormal_olfaction1.28301232
61MP0000569_abnormal_digit_pigmentation1.28229669
62MP0002932_abnormal_joint_morphology1.27769684
63MP0000428_abnormal_craniofacial_morphol1.25731802
64MP0002638_abnormal_pupillary_reflex1.23665389
65MP0003890_abnormal_embryonic-extraembry1.23084590
66MP0002064_seizures1.22551821
67MP0000955_abnormal_spinal_cord1.19651372
68MP0000678_abnormal_parathyroid_gland1.18606681
69MP0002557_abnormal_social/conspecific_i1.18333590
70MP0003123_paternal_imprinting1.15489895
71MP0005195_abnormal_posterior_eye1.15190892
72MP0003119_abnormal_digestive_system1.14613769
73MP0003787_abnormal_imprinting1.14171749
74MP0002081_perinatal_lethality1.14015115
75MP0002152_abnormal_brain_morphology1.13848413
76MP0002177_abnormal_outer_ear1.13032917
77MP0000751_myopathy1.12992919
78MP0000432_abnormal_head_morphology1.12642107
79MP0005187_abnormal_penis_morphology1.12323883
80MP0009384_cardiac_valve_regurgitation1.11216731
81MP0002067_abnormal_sensory_capabilities1.11182650
82MP0009046_muscle_twitch1.10074390
83MP0003315_abnormal_perineum_morphology1.09771696
84MP0002751_abnormal_autonomic_nervous1.08507876
85MP0001286_abnormal_eye_development1.08303541
86MP0004142_abnormal_muscle_tone1.07338379
87MP0003941_abnormal_skin_development1.06699533
88MP0000647_abnormal_sebaceous_gland1.05946898
89MP0001177_atelectasis1.05877267
90MP0001970_abnormal_pain_threshold1.05281593
91MP0002063_abnormal_learning/memory/cond1.04601571
92MP0003635_abnormal_synaptic_transmissio1.03416384
93MP0000538_abnormal_urinary_bladder1.03347455
94MP0005645_abnormal_hypothalamus_physiol1.01990376
95MP0002108_abnormal_muscle_morphology1.01753972
96MP0001963_abnormal_hearing_physiology0.99794966
97MP0002697_abnormal_eye_size0.99726477
98MP0005646_abnormal_pituitary_gland0.99575370
99MP0002109_abnormal_limb_morphology0.99035500
100MP0008438_abnormal_cutaneous_collagen0.99030402
101MP0002928_abnormal_bile_duct0.99026562
102MP0002822_catalepsy0.98283499
103MP0008877_abnormal_DNA_methylation0.96570334
104MP0002095_abnormal_skin_pigmentation0.96131660
105MP0001340_abnormal_eyelid_morphology0.94795407
106MP0005409_darkened_coat_color0.94036248
107MP0005386_behavior/neurological_phenoty0.93656086
108MP0004924_abnormal_behavior0.93656086
109MP0002114_abnormal_axial_skeleton0.93583413
110MP0004742_abnormal_vestibular_system0.93342289
111MP0001293_anophthalmia0.91014675
112MP0001346_abnormal_lacrimal_gland0.90819165
113MP0004134_abnormal_chest_morphology0.90504111
114MP0003011_delayed_dark_adaptation0.90294518
115MP0002102_abnormal_ear_morphology0.88632883
116MP0006276_abnormal_autonomic_nervous0.88341830
117MP0000026_abnormal_inner_ear0.88120016
118MP0000767_abnormal_smooth_muscle0.87026293
119MP0002733_abnormal_thermal_nociception0.87012787
120MP0005508_abnormal_skeleton_morphology0.86564619
121MP0002882_abnormal_neuron_morphology0.85386393
122MP0004811_abnormal_neuron_physiology0.84287211
123MP0001502_abnormal_circadian_rhythm0.83495914
124MP0002092_abnormal_eye_morphology0.83055337
125MP0000163_abnormal_cartilage_morphology0.82973377
126MP0006054_spinal_hemorrhage0.79107217
127MP0001943_abnormal_respiration0.77893113
128MP0002752_abnormal_somatic_nervous0.76248055
129MP0003279_aneurysm0.74104077
130MP0002572_abnormal_emotion/affect_behav0.72743247
131MP0002925_abnormal_cardiovascular_devel0.70159128
132MP0003943_abnormal_hepatobiliary_system0.69589129
133MP0001486_abnormal_startle_reflex0.69411605
134MP0001299_abnormal_eye_distance/0.68773856
135MP0005171_absent_coat_pigmentation0.68704434
136MP0003948_abnormal_gas_homeostasis0.68474349
137MP0005391_vision/eye_phenotype0.68468617
138MP0000762_abnormal_tongue_morphology0.68349805

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.58447723
2Short 4th metacarpal (HP:0010044)4.58447723
3Abnormality of the 4th metacarpal (HP:0010012)3.84115527
4Pancreatic fibrosis (HP:0100732)3.52787092
5Pancreatic cysts (HP:0001737)3.42786778
6Hyperventilation (HP:0002883)3.37531219
7Hepatoblastoma (HP:0002884)3.33771541
8Intestinal atresia (HP:0011100)3.29532982
9Abnormality of the labia minora (HP:0012880)3.20128028
10Congenital primary aphakia (HP:0007707)3.14766220
11Midline defect of the nose (HP:0004122)3.06569124
12Renal duplication (HP:0000075)2.98125639
13Abnormality of the renal medulla (HP:0100957)2.86947212
14Shallow orbits (HP:0000586)2.78494763
15Gastrointestinal atresia (HP:0002589)2.70247567
16Morphological abnormality of the middle ear (HP:0008609)2.67076071
17Focal motor seizures (HP:0011153)2.66981964
18Occipital encephalocele (HP:0002085)2.66600606
19Chronic hepatic failure (HP:0100626)2.65096020
20Renal dysplasia (HP:0000110)2.63994945
21Chorioretinal atrophy (HP:0000533)2.62663751
22Vitreoretinal degeneration (HP:0000655)2.60227331
23Oligodactyly (hands) (HP:0001180)2.54973194
24Cystic liver disease (HP:0006706)2.51403716
25Hypoplastic left heart (HP:0004383)2.50655813
26Postaxial foot polydactyly (HP:0001830)2.45504837
27Mesangial abnormality (HP:0001966)2.45125942
28Trigonocephaly (HP:0000243)2.44047044
29Hemiparesis (HP:0001269)2.43141311
30Oligodactyly (HP:0012165)2.42963295
31Septo-optic dysplasia (HP:0100842)2.42819785
32Sclerocornea (HP:0000647)2.41602751
33Optic nerve hypoplasia (HP:0000609)2.39042884
34Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.37666074
35Split foot (HP:0001839)2.36958476
36Germ cell neoplasia (HP:0100728)2.35440713
37Aplasia/Hypoplasia of the tongue (HP:0010295)2.34277817
38Coronal craniosynostosis (HP:0004440)2.31689209
39Prominent supraorbital ridges (HP:0000336)2.29772011
40Volvulus (HP:0002580)2.29261522
41Type II lissencephaly (HP:0007260)2.26943984
42Esophageal atresia (HP:0002032)2.25101301
43Bifid tongue (HP:0010297)2.25048997
44Absent/shortened dynein arms (HP:0200106)2.24293356
45Dynein arm defect of respiratory motile cilia (HP:0012255)2.24293356
46True hermaphroditism (HP:0010459)2.24077130
47Poor coordination (HP:0002370)2.23509082
48Renovascular hypertension (HP:0100817)2.23312984
49Rhinitis (HP:0012384)2.23028587
50Broad metatarsal (HP:0001783)2.21911295
51Anencephaly (HP:0002323)2.21644712
52Hemivertebrae (HP:0002937)2.18927857
53Long nose (HP:0003189)2.14227170
54Specific learning disability (HP:0001328)2.13449736
55Renal hypoplasia (HP:0000089)2.12995121
56Preaxial hand polydactyly (HP:0001177)2.12489243
57Abnormality of the phalanges of the hallux (HP:0010057)2.10934587
58Aplasia/Hypoplasia of the sternum (HP:0006714)2.09946984
59Embryonal renal neoplasm (HP:0011794)2.09003316
60Cutaneous finger syndactyly (HP:0010554)2.08858770
61Abnormal respiratory motile cilium physiology (HP:0012261)2.08773983
62Broad foot (HP:0001769)2.08086404
63Broad-based gait (HP:0002136)2.07437973
64Elfin facies (HP:0004428)2.01887905
65Shawl scrotum (HP:0000049)2.01161142
66Asymmetry of the thorax (HP:0001555)2.01104375
67Increased corneal curvature (HP:0100692)2.00824997
68Keratoconus (HP:0000563)2.00824997
69Abnormal ciliary motility (HP:0012262)2.00351201
70Absent speech (HP:0001344)1.99941728
71Megalencephaly (HP:0001355)1.99915674
72Cutaneous syndactyly (HP:0012725)1.98781214
73Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.97696095
74Lymphangioma (HP:0100764)1.97465775
75Microglossia (HP:0000171)1.95037453
76Bicornuate uterus (HP:0000813)1.94856042
77Congenital hepatic fibrosis (HP:0002612)1.94234797
78Hyperglycinemia (HP:0002154)1.93752628
79Nephroblastoma (Wilms tumor) (HP:0002667)1.93686869
80Progressive cerebellar ataxia (HP:0002073)1.93418659
81Retinal dysplasia (HP:0007973)1.93183526
82Scrotal hypoplasia (HP:0000046)1.93023955
83Vaginal atresia (HP:0000148)1.92094377
84Aplasia/Hypoplasia of the tibia (HP:0005772)1.92051348
85Narrow forehead (HP:0000341)1.91764474
86Increased nuchal translucency (HP:0010880)1.91327726
87Genital tract atresia (HP:0001827)1.90686231
88Micropenis (HP:0000054)1.90407434
89Choanal stenosis (HP:0000452)1.89737368
90Fibular hypoplasia (HP:0003038)1.89012785
91Abnormality of the aortic arch (HP:0012303)1.88783945
92Broad toe (HP:0001837)1.87997152
93Gait imbalance (HP:0002141)1.86775429
94Absent eyebrow (HP:0002223)1.84765078
95Abnormality of the nasolacrimal system (HP:0000614)1.84345822
96Abnormality of midbrain morphology (HP:0002418)1.84240029
97Molar tooth sign on MRI (HP:0002419)1.84240029
98Facial cleft (HP:0002006)1.83602260
99Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.83346629
100Omphalocele (HP:0001539)1.82926418
101Excessive salivation (HP:0003781)1.82919774
102Drooling (HP:0002307)1.82919774
103Tented upper lip vermilion (HP:0010804)1.82299164
104Focal seizures (HP:0007359)1.81861003
105Male pseudohermaphroditism (HP:0000037)1.81596720
106Preaxial foot polydactyly (HP:0001841)1.81542030
107Hypoplastic heart (HP:0001961)1.81319394
108Short tibia (HP:0005736)1.81012517
109Abnormal respiratory motile cilium morphology (HP:0005938)1.80995316
110Abnormal respiratory epithelium morphology (HP:0012253)1.80995316
111Anterior segment dysgenesis (HP:0007700)1.80663254
112Abolished electroretinogram (ERG) (HP:0000550)1.79167800
113Rib fusion (HP:0000902)1.79043731
114Abnormality of the lacrimal duct (HP:0011481)1.78945126
115Humeroradial synostosis (HP:0003041)1.78443228
116Synostosis involving the elbow (HP:0003938)1.78443228
117Rimmed vacuoles (HP:0003805)1.77215971
118Cerebellar dysplasia (HP:0007033)1.77201446
119Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.76936378
120Degeneration of the lateral corticospinal tracts (HP:0002314)1.76936378
121Bell-shaped thorax (HP:0001591)1.76342174
122Absent hair (HP:0002298)1.76250493
123Abnormality of the pubic bones (HP:0003172)1.75080140
124Aplasia/Hypoplasia of the lens (HP:0008063)1.74147060
125Decreased lacrimation (HP:0000633)1.73714010
126Adactyly (HP:0009776)1.73649140
127Short foot (HP:0001773)1.73058428
128Atonic seizures (HP:0010819)1.72882657
129Patellar dislocation (HP:0002999)1.72798586
130Aplasia/Hypoplasia of the fibula (HP:0006492)1.72384330
131Aganglionic megacolon (HP:0002251)1.72313569
132Flat cornea (HP:0007720)1.71991850
133Hyperacusis (HP:0010780)1.71795991
134Nephronophthisis (HP:0000090)1.70854353
135Limb dystonia (HP:0002451)1.69227721
136Skull defect (HP:0001362)1.68271827
137Accelerated skeletal maturation (HP:0005616)1.68229177
138Polyphagia (HP:0002591)1.68154635
139Abnormality of the diencephalon (HP:0010662)1.67104822
140Overriding aorta (HP:0002623)1.66979202
141Advanced eruption of teeth (HP:0006288)1.66410128
142Nephrogenic diabetes insipidus (HP:0009806)1.66186684
143Anophthalmia (HP:0000528)1.66073792
144Abnormality of the antihelix (HP:0009738)1.65017569
145Postaxial hand polydactyly (HP:0001162)1.64717480
146Abnormal lung lobation (HP:0002101)1.64312040
147Abnormality of the intervertebral disk (HP:0005108)1.62837712
148Medial flaring of the eyebrow (HP:0010747)1.62756365
149Optic nerve coloboma (HP:0000588)1.62696528
150Hypospadias (HP:0000047)1.62432354
151Down-sloping shoulders (HP:0200021)1.61776984
152Short philtrum (HP:0000322)1.60477212
153Natal tooth (HP:0000695)1.60399093
154Intellectual disability, moderate (HP:0002342)1.60143271
155Papillary thyroid carcinoma (HP:0002895)1.60132086
156Hypoplasia of the brainstem (HP:0002365)1.60048646
157Aplasia/Hypoplasia of the brainstem (HP:0007362)1.60048646
158High anterior hairline (HP:0009890)1.59855493
159Exotropia (HP:0000577)1.58519527
160Lissencephaly (HP:0001339)1.58387914
161Overgrowth (HP:0001548)1.57272152
162Pachygyria (HP:0001302)1.56450813
163Embryonal neoplasm (HP:0002898)1.55964242

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.65745613
2EPHB23.28887487
3PNCK2.73381595
4NTRK22.65519350
5MAPK152.59499607
6MAP4K22.51085387
7MAPK132.47248681
8FRK2.31875187
9TNIK2.27197385
10ERBB32.25798487
11LATS12.19822312
12CASK2.19743587
13LMTK22.09564014
14PHKG22.04619463
15PHKG12.04619463
16DYRK21.97928834
17PINK11.93084100
18ICK1.90946531
19TGFBR11.90545685
20MAP3K41.83945920
21ADRBK21.72848093
22CCNB11.72798356
23SGK21.63117737
24SIK31.60867401
25WNK31.59358078
26PASK1.52932788
27MKNK11.49704127
28NUAK11.44257814
29TIE11.43885265
30PDGFRA1.43393548
31YES11.42607508
32KSR11.39732900
33PAK31.39496180
34IRAK21.36960065
35BMPR1B1.33577073
36NTRK31.33294106
37SGK4941.31767420
38SGK2231.31767420
39PRKD31.26431773
40MAP2K71.24276503
41EPHA41.21626222
42RPS6KA21.19899581
43PLK21.19470213
44STK391.19273484
45TGFBR21.18089813
46LATS21.12614248
47MKNK21.08237168
48ROCK11.06492448
49SGK31.05479679
50FGFR21.05363839
51UHMK11.03838993
52BCR1.02299842
53WEE11.01949792
54WNK41.00463547
55EPHB10.99851539
56ERBB20.96564596
57MINK10.95835432
58INSRR0.94016431
59DYRK30.93781934
60CDK30.90172828
61MAP3K100.89060413
62TRIM280.88233010
63MYLK0.83952912
64PLK40.83699831
65FER0.82591102
66GRK10.80590070
67VRK10.80420108
68EPHA30.79697678
69PTK2B0.79300831
70SIK20.77452085
71ROCK20.76533107
72PDK20.76291577
73CAMK40.74951179
74DYRK1A0.74292019
75CDK80.73549039
76CAMK1G0.68381553
77BCKDK0.67569788
78TRIB30.66594640
79PKN10.66137662
80SRPK10.65466953
81CAMK2A0.62793372
82CSNK1A1L0.61938508
83ZAK0.61101181
84STK38L0.60430324
85TSSK60.60242705
86PRKCZ0.59870177
87TTN0.59563321
88PLK30.59222183
89CSNK1G10.58318335
90DMPK0.57753010
91LIMK10.57333141
92CDK50.57199830
93TYRO30.56912234
94CSNK1G30.55103149
95MAPK70.54681854
96MAPK90.53700730
97PDGFRB0.52210455
98CSNK1G20.51974954
99PAK40.51697954
100IRAK10.51217615
101DDR20.51135553
102ACVR1B0.50490643
103PRKCE0.49022219
104CAMKK10.48753180
105RPS6KA40.47695880
106MARK20.47549145
107CHEK20.47308416
108OXSR10.47202064
109EIF2AK20.47187064
110BRD40.46439119
111FGFR10.46423404
112RPS6KL10.45936107
113RPS6KC10.45936107
114CDK180.44561277
115NEK60.43936687
116MAPK80.42655617
117CAMK2B0.42227196
118DYRK1B0.41832200
119PDK30.41695227
120PDK40.41695227
121PIK3CA0.41481687
122PRKCG0.41338474
123ADRBK10.41063940
124CDK140.40180275
125PAK60.38422783
126PRKG10.37590565
127CSNK1A10.37559732
128CSNK1D0.37039875
129NEK90.35498369
130PRKACA0.34657518
131CAMK2D0.33023227
132RPS6KA50.31324968
133PLK10.30321643
134PRKACB0.28536959
135BRSK20.27446621
136MAP2K40.26444834

Predicted pathways (KEGG)

RankGene SetZ-score
1Axon guidance_Homo sapiens_hsa043603.54458240
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.00748798
3Basal cell carcinoma_Homo sapiens_hsa052172.72893003
4Steroid biosynthesis_Homo sapiens_hsa001002.68650167
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.36992676
6Hedgehog signaling pathway_Homo sapiens_hsa043402.35129234
7Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.11736226
8Propanoate metabolism_Homo sapiens_hsa006401.93304310
9Hippo signaling pathway_Homo sapiens_hsa043901.89717899
10Protein export_Homo sapiens_hsa030601.88516611
11Nitrogen metabolism_Homo sapiens_hsa009101.87258808
12Phototransduction_Homo sapiens_hsa047441.82631051
13Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.70983456
14Colorectal cancer_Homo sapiens_hsa052101.68718029
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.66347122
16Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.66266554
17Wnt signaling pathway_Homo sapiens_hsa043101.60436093
18Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.56720090
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.56106425
20Gap junction_Homo sapiens_hsa045401.55432141
21Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.54930253
22Endometrial cancer_Homo sapiens_hsa052131.53773052
23Basal transcription factors_Homo sapiens_hsa030221.53225247
24Dilated cardiomyopathy_Homo sapiens_hsa054141.51952899
25Melanogenesis_Homo sapiens_hsa049161.49102072
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.48592061
27Notch signaling pathway_Homo sapiens_hsa043301.46199577
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.42824423
29Cocaine addiction_Homo sapiens_hsa050301.38857185
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.37689522
31Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.36978494
32Adherens junction_Homo sapiens_hsa045201.36772536
33Circadian entrainment_Homo sapiens_hsa047131.36545787
34TGF-beta signaling pathway_Homo sapiens_hsa043501.34440148
35Nicotine addiction_Homo sapiens_hsa050331.34382290
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30723234
37MicroRNAs in cancer_Homo sapiens_hsa052061.29509430
38Renin secretion_Homo sapiens_hsa049241.28180703
39Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.25922235
40Lysine degradation_Homo sapiens_hsa003101.25658391
41Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.25337042
42ECM-receptor interaction_Homo sapiens_hsa045121.23001413
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.22739527
44Glutamatergic synapse_Homo sapiens_hsa047241.18782554
45Peroxisome_Homo sapiens_hsa041461.18456581
46Focal adhesion_Homo sapiens_hsa045101.16853827
47alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.16323334
48Dorso-ventral axis formation_Homo sapiens_hsa043201.13224780
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.11125947
50Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.10801237
51Thyroid hormone signaling pathway_Homo sapiens_hsa049191.10705183
52Linoleic acid metabolism_Homo sapiens_hsa005911.09271389
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.08763469
54Prostate cancer_Homo sapiens_hsa052151.08647117
55Fanconi anemia pathway_Homo sapiens_hsa034601.08440387
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.07760575
57Oocyte meiosis_Homo sapiens_hsa041141.07419840
58Estrogen signaling pathway_Homo sapiens_hsa049151.07245981
59Viral myocarditis_Homo sapiens_hsa054161.07025971
60Dopaminergic synapse_Homo sapiens_hsa047281.06786173
61Cholinergic synapse_Homo sapiens_hsa047251.05406890
62Neurotrophin signaling pathway_Homo sapiens_hsa047221.03858024
63Proteoglycans in cancer_Homo sapiens_hsa052051.03437690
64Pathways in cancer_Homo sapiens_hsa052001.01957355
65Rap1 signaling pathway_Homo sapiens_hsa040151.01703523
66Glioma_Homo sapiens_hsa052141.01490414
67AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.01254865
68Gastric acid secretion_Homo sapiens_hsa049711.01129824
69Caffeine metabolism_Homo sapiens_hsa002321.00256290
70Cell cycle_Homo sapiens_hsa041100.99353768
71beta-Alanine metabolism_Homo sapiens_hsa004100.98978213
72cAMP signaling pathway_Homo sapiens_hsa040240.97421134
73GnRH signaling pathway_Homo sapiens_hsa049120.97260681
74Fatty acid metabolism_Homo sapiens_hsa012120.97164212
75cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96541798
76Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.96356104
77Tryptophan metabolism_Homo sapiens_hsa003800.96220254
78Renal cell carcinoma_Homo sapiens_hsa052110.96131777
79Olfactory transduction_Homo sapiens_hsa047400.94385323
80ErbB signaling pathway_Homo sapiens_hsa040120.94035668
81HTLV-I infection_Homo sapiens_hsa051660.93722785
82Aldosterone synthesis and secretion_Homo sapiens_hsa049250.93658529
83Morphine addiction_Homo sapiens_hsa050320.93485600
84mRNA surveillance pathway_Homo sapiens_hsa030150.92450780
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.92359393
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.92211883
87GABAergic synapse_Homo sapiens_hsa047270.92156911
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.92086422
89Amphetamine addiction_Homo sapiens_hsa050310.91877179
90Primary bile acid biosynthesis_Homo sapiens_hsa001200.91495963
91Spliceosome_Homo sapiens_hsa030400.91319170
92Melanoma_Homo sapiens_hsa052180.90496437
93Butanoate metabolism_Homo sapiens_hsa006500.88197963
94Insulin secretion_Homo sapiens_hsa049110.87964431
95Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.87263342
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.87068001
97Salivary secretion_Homo sapiens_hsa049700.85878584
98Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.85107239
99Long-term depression_Homo sapiens_hsa047300.84904195
100Huntingtons disease_Homo sapiens_hsa050160.83706591
101Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83614160
102Oxytocin signaling pathway_Homo sapiens_hsa049210.82352411
103MAPK signaling pathway_Homo sapiens_hsa040100.80842448
104Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.80803284
105Retinol metabolism_Homo sapiens_hsa008300.80778275
106Circadian rhythm_Homo sapiens_hsa047100.79106844
107PI3K-Akt signaling pathway_Homo sapiens_hsa041510.79100195
108Ovarian steroidogenesis_Homo sapiens_hsa049130.79050639
109Ether lipid metabolism_Homo sapiens_hsa005650.78623200
110Oxidative phosphorylation_Homo sapiens_hsa001900.78249795
111Chronic myeloid leukemia_Homo sapiens_hsa052200.77378235
112Long-term potentiation_Homo sapiens_hsa047200.76803548
113Cardiac muscle contraction_Homo sapiens_hsa042600.76536353
114Chemical carcinogenesis_Homo sapiens_hsa052040.76339881
115Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75511321
116Histidine metabolism_Homo sapiens_hsa003400.75083185
117Serotonergic synapse_Homo sapiens_hsa047260.74970705
118Pancreatic cancer_Homo sapiens_hsa052120.74804992
119Small cell lung cancer_Homo sapiens_hsa052220.73627889
120Tight junction_Homo sapiens_hsa045300.73324154
121Maturity onset diabetes of the young_Homo sapiens_hsa049500.72513689
122Calcium signaling pathway_Homo sapiens_hsa040200.72116619
123Vitamin B6 metabolism_Homo sapiens_hsa007500.70382859
124Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69759491
125Fatty acid degradation_Homo sapiens_hsa000710.69388331
126Taste transduction_Homo sapiens_hsa047420.68751526
127Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68617624
128ABC transporters_Homo sapiens_hsa020100.67716719
129Glycerolipid metabolism_Homo sapiens_hsa005610.67584733
130Non-small cell lung cancer_Homo sapiens_hsa052230.67492175
131FoxO signaling pathway_Homo sapiens_hsa040680.66738222
132Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64219879
133Regulation of autophagy_Homo sapiens_hsa041400.64122573
134N-Glycan biosynthesis_Homo sapiens_hsa005100.62007664
135Insulin signaling pathway_Homo sapiens_hsa049100.60735674
136Parkinsons disease_Homo sapiens_hsa050120.60427490
137Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60000325
138RNA polymerase_Homo sapiens_hsa030200.58676012
139Arginine and proline metabolism_Homo sapiens_hsa003300.58119400
140Ras signaling pathway_Homo sapiens_hsa040140.57998331
141RNA degradation_Homo sapiens_hsa030180.56463974
142Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55882800
143Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54410449
144Alcoholism_Homo sapiens_hsa050340.54342946
145Fatty acid biosynthesis_Homo sapiens_hsa000610.53187934
146Type II diabetes mellitus_Homo sapiens_hsa049300.51408271
147Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.51323165
148Choline metabolism in cancer_Homo sapiens_hsa052310.50897124
149Thyroid hormone synthesis_Homo sapiens_hsa049180.50403780
150Protein digestion and absorption_Homo sapiens_hsa049740.50397951
151PPAR signaling pathway_Homo sapiens_hsa033200.49168238
152Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48792363
153Glucagon signaling pathway_Homo sapiens_hsa049220.48064716
154Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.47595771
155Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45985936
156Alzheimers disease_Homo sapiens_hsa050100.44946439
157Cysteine and methionine metabolism_Homo sapiens_hsa002700.39403797

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