SNCB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a small family of proteins that inhibit phospholipase D2 and may function in neuronal plasticity. The encoded protein is abundant in lesions of patients with Alzheimer disease. A mutation in this gene was found in individuals with dementia with Lewy bodies. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)7.16338813
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.90928068
3locomotory exploration behavior (GO:0035641)6.29502380
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)6.10779913
5glutamate secretion (GO:0014047)6.03240676
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.97325210
7synaptic vesicle exocytosis (GO:0016079)5.93165791
8synaptic vesicle docking involved in exocytosis (GO:0016081)5.74908666
9regulation of synaptic vesicle exocytosis (GO:2000300)5.69570292
10vocalization behavior (GO:0071625)5.69183255
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.45102361
12regulation of glutamate receptor signaling pathway (GO:1900449)5.09414304
13regulation of synaptic vesicle transport (GO:1902803)5.05406858
14neurotransmitter secretion (GO:0007269)5.04451435
15protein localization to synapse (GO:0035418)4.88950871
16exploration behavior (GO:0035640)4.80023407
17neuronal action potential propagation (GO:0019227)4.73852130
18regulation of neuronal synaptic plasticity (GO:0048168)4.67667186
19layer formation in cerebral cortex (GO:0021819)4.62882531
20regulation of long-term neuronal synaptic plasticity (GO:0048169)4.58452831
21ionotropic glutamate receptor signaling pathway (GO:0035235)4.57642609
22amino acid import (GO:0043090)4.55116982
23gamma-aminobutyric acid transport (GO:0015812)4.47720604
24cellular potassium ion homeostasis (GO:0030007)4.46557245
25sodium ion export (GO:0071436)4.37039305
26axon ensheathment in central nervous system (GO:0032291)4.34055412
27central nervous system myelination (GO:0022010)4.34055412
28neuron cell-cell adhesion (GO:0007158)4.28992457
29proline transport (GO:0015824)4.25955151
30neurotransmitter-gated ion channel clustering (GO:0072578)4.24148110
31regulation of synapse structural plasticity (GO:0051823)4.19964850
32synaptic transmission, glutamatergic (GO:0035249)4.18758569
33dendritic spine morphogenesis (GO:0060997)4.17443066
34regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.09843423
35neurotransmitter transport (GO:0006836)4.04878386
36regulation of synapse maturation (GO:0090128)4.04300250
37long-term memory (GO:0007616)4.01217370
38positive regulation of membrane potential (GO:0045838)3.99917432
39glutamate receptor signaling pathway (GO:0007215)3.99505993
40positive regulation of dendritic spine morphogenesis (GO:0061003)3.98222819
41negative regulation of dendrite morphogenesis (GO:0050774)3.90101335
42neuron-neuron synaptic transmission (GO:0007270)3.88938132
43activation of protein kinase A activity (GO:0034199)3.86302747
44glycine transport (GO:0015816)3.84518167
45membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.82165830
46regulation of excitatory postsynaptic membrane potential (GO:0060079)3.77871620
47regulation of neurotransmitter secretion (GO:0046928)3.74980983
48cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.74836499
49neuromuscular process controlling posture (GO:0050884)3.73261205
50regulation of neurotransmitter levels (GO:0001505)3.71476570
51synaptic vesicle endocytosis (GO:0048488)3.70327498
52positive regulation of synapse maturation (GO:0090129)3.66163328
53cerebellar Purkinje cell differentiation (GO:0021702)3.63649471
54regulation of synaptic plasticity (GO:0048167)3.63012500
55regulation of dendritic spine development (GO:0060998)3.62707957
56neuromuscular process controlling balance (GO:0050885)3.61884335
57regulation of postsynaptic membrane potential (GO:0060078)3.60949481
58positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.56983433
59cell communication by electrical coupling (GO:0010644)3.53046173
60regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.49554241
61regulation of neurotransmitter transport (GO:0051588)3.43642232
62acidic amino acid transport (GO:0015800)3.43259284
63neurotransmitter uptake (GO:0001504)3.42327251
64regulation of dendritic spine morphogenesis (GO:0061001)3.40444725
65regulation of vesicle fusion (GO:0031338)3.38215547
66long-term synaptic potentiation (GO:0060291)3.36027477
67vesicle docking involved in exocytosis (GO:0006904)3.35809279
68synaptic vesicle transport (GO:0048489)3.35365396
69establishment of synaptic vesicle localization (GO:0097480)3.35365396
70positive regulation of synaptic transmission, GABAergic (GO:0032230)3.34186773
71postsynaptic membrane organization (GO:0001941)3.33182471
72regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.32987268
73positive regulation of neurotransmitter transport (GO:0051590)3.32147568
74auditory behavior (GO:0031223)3.32058729
75cytoskeletal anchoring at plasma membrane (GO:0007016)3.30191550
76L-amino acid import (GO:0043092)3.29932176
77regulation of ARF protein signal transduction (GO:0032012)3.29774784
78negative regulation of synaptic transmission, GABAergic (GO:0032229)3.29606714
79gamma-aminobutyric acid signaling pathway (GO:0007214)3.28276253
80positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.28275524
81transmission of nerve impulse (GO:0019226)3.27632880
82positive regulation of neurotransmitter secretion (GO:0001956)3.26814617
83positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.25158270
84neuron recognition (GO:0008038)3.23894150
85response to auditory stimulus (GO:0010996)3.23151782
86regulation of exocytosis (GO:0017157)3.21389127
87dendrite morphogenesis (GO:0048813)3.20324611
88regulation of synaptic transmission, glutamatergic (GO:0051966)3.19451449
89potassium ion import (GO:0010107)3.19158347
90neuromuscular synaptic transmission (GO:0007274)3.16694194
91cell differentiation in hindbrain (GO:0021533)3.16674438
92membrane hyperpolarization (GO:0060081)3.15678014
93chemosensory behavior (GO:0007635)3.15352690
94vesicle transport along microtubule (GO:0047496)3.11866272
95dicarboxylic acid transport (GO:0006835)3.11856512
96signal release (GO:0023061)3.11041497
97membrane depolarization (GO:0051899)3.10926915
98membrane depolarization during action potential (GO:0086010)3.10238055
99vesicle docking (GO:0048278)3.09972413
100regulation of synaptic transmission (GO:0050804)3.07358052
101positive regulation of synaptic transmission (GO:0050806)3.07103211
102regulation of voltage-gated calcium channel activity (GO:1901385)3.05834073
103positive regulation of dendrite development (GO:1900006)3.05362915
104response to pheromone (GO:0019236)3.05361012
105G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.04782090
106intraspecies interaction between organisms (GO:0051703)3.04666263
107social behavior (GO:0035176)3.04666263
108neuromuscular process (GO:0050905)3.04659472
109dendritic spine organization (GO:0097061)3.02785083
110potassium ion homeostasis (GO:0055075)3.02579952
111cerebellar Purkinje cell layer development (GO:0021680)3.02106517
112prepulse inhibition (GO:0060134)3.01891078
113regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.01851230
114* synaptic transmission (GO:0007268)3.00283888
115neuronal ion channel clustering (GO:0045161)3.00187430
116cellular sodium ion homeostasis (GO:0006883)2.99552899
117innervation (GO:0060384)2.99323229
118cerebellar granule cell differentiation (GO:0021707)2.99084224
119positive regulation of dendritic spine development (GO:0060999)2.99013340
120G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.98633475
121learning (GO:0007612)2.98298316

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.84316704
2* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.13192571
3* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.06796866
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.06545803
5GBX2_23144817_ChIP-Seq_PC3_Human2.99225062
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.95868726
7* RARB_27405468_Chip-Seq_BRAIN_Mouse2.84604905
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.82819189
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.82819189
10DROSHA_22980978_ChIP-Seq_HELA_Human2.80845017
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.72651493
12* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.65682699
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.62280783
14* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.54093110
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.52763915
16* REST_18959480_ChIP-ChIP_MESCs_Mouse2.49391911
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.45256800
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.44565629
19IKZF1_21737484_ChIP-ChIP_HCT116_Human2.41056948
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.40220002
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.37901218
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.36366664
23EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.34691927
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.29429778
25* RNF2_27304074_Chip-Seq_ESCs_Mouse2.22125767
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.18676578
27* EED_16625203_ChIP-ChIP_MESCs_Mouse2.12264014
28ERG_21242973_ChIP-ChIP_JURKAT_Human1.81806215
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.79815260
30AR_21572438_ChIP-Seq_LNCaP_Human1.77897103
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.76237881
32DNAJC2_21179169_ChIP-ChIP_NT2_Human1.55811730
33* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.51718883
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.47838710
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47238276
36SMAD4_21799915_ChIP-Seq_A2780_Human1.44844278
37RING1B_27294783_Chip-Seq_ESCs_Mouse1.40206512
38SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.37808080
39ZFP281_18757296_ChIP-ChIP_E14_Mouse1.37092515
40* KDM2B_26808549_Chip-Seq_K562_Human1.35461083
41* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.32772442
42LXR_22292898_ChIP-Seq_THP-1_Human1.32108658
43* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.30406485
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30156086
45* SOX2_21211035_ChIP-Seq_LN229_Gbm1.24957253
46ZNF274_21170338_ChIP-Seq_K562_Hela1.24921963
47AR_19668381_ChIP-Seq_PC3_Human1.24035476
48TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22338383
49NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22180738
50WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19910504
51WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.18707950
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17338593
53ESR2_21235772_ChIP-Seq_MCF-7_Human1.16743570
54PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.16136973
55CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.15806126
56SMAD_19615063_ChIP-ChIP_OVARY_Human1.13666452
57RING1B_27294783_Chip-Seq_NPCs_Mouse1.13245997
58PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.13076284
59OCT4_19829295_ChIP-Seq_ESCs_Human1.12575026
60TAF15_26573619_Chip-Seq_HEK293_Human1.12223707
61* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11152185
62SRY_22984422_ChIP-ChIP_TESTIS_Rat1.10773418
63GATA1_26923725_Chip-Seq_HPCs_Mouse1.10288629
64* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.10170579
65AR_25329375_ChIP-Seq_VCAP_Human1.09871474
66ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.08981988
67P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08864973
68RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.07839883
69STAT3_23295773_ChIP-Seq_U87_Human1.07478894
70SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.05495030
71SMAD3_21741376_ChIP-Seq_EPCs_Human1.01927093
72DPY_21335234_ChIP-Seq_ESCs_Mouse1.01294640
73TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01264613
74ZFP281_27345836_Chip-Seq_ESCs_Mouse1.00299439
75P300_19829295_ChIP-Seq_ESCs_Human0.99368851
76TET1_21490601_ChIP-Seq_MESCs_Mouse0.98818132
77* RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.98226036
78SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97951956
79PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.97828426
80YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97365290
81* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.97282440
82* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.96982209
83TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.96882780
84THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.96612228
85MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95511188
86SMAD3_21741376_ChIP-Seq_ESCs_Human0.94964078
87CTCF_27219007_Chip-Seq_Bcells_Human0.94466162
88TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93679931
89TCF4_23295773_ChIP-Seq_U87_Human0.93077105
90* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.92841499
91ZNF217_24962896_ChIP-Seq_MCF-7_Human0.92561990
92P68_20966046_ChIP-Seq_HELA_Human0.92243862
93CBX2_27304074_Chip-Seq_ESCs_Mouse0.91850252
94SMAD4_21741376_ChIP-Seq_HESCs_Human0.91513213
95CREB1_26743006_Chip-Seq_LNCaP_Human0.90839895
96ARNT_22903824_ChIP-Seq_MCF-7_Human0.90244167
97SMAD3_21741376_ChIP-Seq_HESCs_Human0.88772299
98OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88506360
99EGR1_19032775_ChIP-ChIP_M12_Human0.88497272
100ZFP57_27257070_Chip-Seq_ESCs_Mouse0.87917811
101SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87589778
102CDX2_19796622_ChIP-Seq_MESCs_Mouse0.87269763
103AHR_22903824_ChIP-Seq_MCF-7_Human0.86359095
104KDM2B_26808549_Chip-Seq_SUP-B15_Human0.85589636
105RNF2_27304074_Chip-Seq_NSC_Mouse0.85189068
106SMAD4_21741376_ChIP-Seq_ESCs_Human0.84372483
107TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.83752948
108KDM2B_26808549_Chip-Seq_DND41_Human0.83522456
109RXR_22108803_ChIP-Seq_LS180_Human0.83451664
110VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.83175303
111PIAS1_25552417_ChIP-Seq_VCAP_Human0.82930414
112MYC_19915707_ChIP-ChIP_AK7_Human0.81709796
113BMI1_23680149_ChIP-Seq_NPCS_Mouse0.81653262
114DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.80796699
115SMC4_20622854_ChIP-Seq_HELA_Human0.80596078
116TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80558726
117KLF4_19829295_ChIP-Seq_ESCs_Human0.80274870
118PRDM14_20953172_ChIP-Seq_ESCs_Human0.79678850
119SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79584018
120GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77947181
121NR3C1_21868756_ChIP-Seq_MCF10A_Human0.77745687
122PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.77453034
123UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.76836329
124GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.76641022
125RUNX1_26923725_Chip-Seq_HPCs_Mouse0.76447350
126CTNNB1_20460455_ChIP-Seq_HCT116_Human0.75481987
127KDM2B_26808549_Chip-Seq_JURKAT_Human0.72759270
128TP53_20018659_ChIP-ChIP_R1E_Mouse0.71765725
129CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.70668731
130TET1_21451524_ChIP-Seq_MESCs_Mouse0.70012555
131TP53_23651856_ChIP-Seq_MEFs_Mouse0.68532616
132TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.67926564

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.09474556
2MP0003880_abnormal_central_pattern4.67108262
3MP0003635_abnormal_synaptic_transmissio4.37133009
4MP0004270_analgesia3.80280558
5MP0009745_abnormal_behavioral_response3.47867665
6MP0002063_abnormal_learning/memory/cond3.38536852
7MP0002064_seizures3.34125135
8MP0009046_muscle_twitch3.31669490
9MP0005423_abnormal_somatic_nervous3.15015860
10MP0001968_abnormal_touch/_nociception2.94307209
11MP0002572_abnormal_emotion/affect_behav2.77772680
12MP0002734_abnormal_mechanical_nocicepti2.74225550
13MP0002272_abnormal_nervous_system2.68150720
14MP0001486_abnormal_startle_reflex2.62949217
15MP0002822_catalepsy2.36213432
16MP0001501_abnormal_sleep_pattern2.34349599
17MP0008569_lethality_at_weaning2.17732006
18MP0002736_abnormal_nociception_after2.16450975
19MP0009780_abnormal_chondrocyte_physiolo2.16417888
20MP0001440_abnormal_grooming_behavior2.09210028
21MP0002735_abnormal_chemical_nociception2.03381436
22MP0002733_abnormal_thermal_nociception2.03070868
23MP0001970_abnormal_pain_threshold1.99545539
24MP0003329_amyloid_beta_deposits1.97700993
25MP0004858_abnormal_nervous_system1.96448077
26MP0002067_abnormal_sensory_capabilities1.94375063
27MP0004811_abnormal_neuron_physiology1.88694220
28MP0002909_abnormal_adrenal_gland1.81908327
29MP0002184_abnormal_innervation1.74989454
30MP0002557_abnormal_social/conspecific_i1.72702835
31MP0003879_abnormal_hair_cell1.66997262
32MP0004885_abnormal_endolymph1.66912352
33MP0004924_abnormal_behavior1.66801399
34MP0005386_behavior/neurological_phenoty1.66801399
35MP0000955_abnormal_spinal_cord1.62552388
36MP0000778_abnormal_nervous_system1.60546024
37MP0003787_abnormal_imprinting1.57152899
38MP0005646_abnormal_pituitary_gland1.54989560
39MP0002882_abnormal_neuron_morphology1.47889537
40MP0003633_abnormal_nervous_system1.46967720
41MP0002066_abnormal_motor_capabilities/c1.46471182
42MP0003123_paternal_imprinting1.39244417
43MP0001984_abnormal_olfaction1.34337960
44MP0004142_abnormal_muscle_tone1.34107245
45MP0001502_abnormal_circadian_rhythm1.33879471
46MP0006276_abnormal_autonomic_nervous1.33653438
47MP0005551_abnormal_eye_electrophysiolog1.29824470
48MP0003631_nervous_system_phenotype1.22656818
49MP0003122_maternal_imprinting1.21489558
50MP0005645_abnormal_hypothalamus_physiol1.20134851
51MP0002229_neurodegeneration1.12010086
52MP0001905_abnormal_dopamine_level1.09775938
53MP0002152_abnormal_brain_morphology1.09415479
54MP0008872_abnormal_physiological_respon1.07616949
55MP0003075_altered_response_to1.06920536
56MP0008961_abnormal_basal_metabolism1.05749427
57MP0003283_abnormal_digestive_organ1.04683622
58MP0003690_abnormal_glial_cell1.01421402
59MP0000751_myopathy0.99811263
60MP0001346_abnormal_lacrimal_gland0.97035831
61MP0000013_abnormal_adipose_tissue0.95773509
62MP0002069_abnormal_eating/drinking_beha0.95365413
63MP0004145_abnormal_muscle_electrophysio0.94687257
64MP0003634_abnormal_glial_cell0.92737371
65MP0000569_abnormal_digit_pigmentation0.91926922
66MP0001177_atelectasis0.91424567
67MP0002090_abnormal_vision0.90695606
68MP0004147_increased_porphyrin_level0.90649777
69MP0008874_decreased_physiological_sensi0.90047982
70MP0000604_amyloidosis0.89752939
71MP0003632_abnormal_nervous_system0.89319752
72MP0000920_abnormal_myelination0.87746201
73MP0005535_abnormal_body_temperature0.84510870
74MP0005167_abnormal_blood-brain_barrier0.81055770
75MP0001529_abnormal_vocalization0.81052889
76MP0005499_abnormal_olfactory_system0.80203419
77MP0005394_taste/olfaction_phenotype0.80203419
78MP0001348_abnormal_lacrimal_gland0.79250270
79MP0004742_abnormal_vestibular_system0.79020253
80MP0004233_abnormal_muscle_weight0.76747822
81MP0001963_abnormal_hearing_physiology0.76200232
82MP0003172_abnormal_lysosome_physiology0.75899696
83MP0002752_abnormal_somatic_nervous0.75357002
84MP0010386_abnormal_urinary_bladder0.74971790
85MP0004085_abnormal_heartbeat0.74902173
86MP0001986_abnormal_taste_sensitivity0.74529941
87MP0006072_abnormal_retinal_apoptosis0.71574451
88MP0005623_abnormal_meninges_morphology0.70864288
89MP0008877_abnormal_DNA_methylation0.70345781
90MP0002638_abnormal_pupillary_reflex0.70134535
91MP0004043_abnormal_pH_regulation0.67836495
92MP0004215_abnormal_myocardial_fiber0.64085467
93MP0004130_abnormal_muscle_cell0.64055899
94MP0005166_decreased_susceptibility_to0.63100088
95MP0005253_abnormal_eye_physiology0.62192530
96MP0003137_abnormal_impulse_conducting0.62121095
97MP0000631_abnormal_neuroendocrine_gland0.60547007
98MP0004510_myositis0.60277834
99MP0004484_altered_response_of0.58088687
100MP0001664_abnormal_digestion0.57293345
101MP0001188_hyperpigmentation0.56156856
102MP0010769_abnormal_survival0.55037831
103MP0010234_abnormal_vibrissa_follicle0.53460713
104MP0000579_abnormal_nail_morphology0.53090623
105MP0001943_abnormal_respiration0.52366546
106MP0002089_abnormal_postnatal_growth/wei0.52351638
107MP0003956_abnormal_body_size0.52100180
108MP0001299_abnormal_eye_distance/0.51677087
109MP0001485_abnormal_pinna_reflex0.51674824
110MP0010768_mortality/aging0.49998409
111MP0002082_postnatal_lethality0.47733487
112MP0010770_preweaning_lethality0.47733487
113* MP0002873_normal_phenotype0.45361941
114MP0003121_genomic_imprinting0.44219300
115* MP0002169_no_abnormal_phenotype0.43785373
116MP0000026_abnormal_inner_ear0.42612251
117MP0003183_abnormal_peptide_metabolism0.42228053
118MP0000639_abnormal_adrenal_gland0.41443071
119MP0003861_abnormal_nervous_system0.41142119

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.36604352
2Focal motor seizures (HP:0011153)7.16888769
3Focal seizures (HP:0007359)5.67285307
4Epileptic encephalopathy (HP:0200134)4.84811130
5Progressive cerebellar ataxia (HP:0002073)4.69529324
6Atonic seizures (HP:0010819)4.63053818
7Febrile seizures (HP:0002373)4.52565802
8Action tremor (HP:0002345)4.34143964
9* Visual hallucinations (HP:0002367)4.18381774
10Absence seizures (HP:0002121)4.12813745
11Supranuclear gaze palsy (HP:0000605)4.04229256
12Generalized tonic-clonic seizures (HP:0002069)3.92667612
13Ankle clonus (HP:0011448)3.88847463
14Cerebral hypomyelination (HP:0006808)3.87961589
15Dialeptic seizures (HP:0011146)3.68612898
16Depression (HP:0000716)3.59826669
17Mutism (HP:0002300)3.57846057
18Impaired vibration sensation in the lower limbs (HP:0002166)3.45991426
19Poor eye contact (HP:0000817)3.42221238
20Papilledema (HP:0001085)3.40106095
21Dysdiadochokinesis (HP:0002075)3.38843229
22Postural instability (HP:0002172)3.38402406
23Gaze-evoked nystagmus (HP:0000640)3.32419445
24Broad-based gait (HP:0002136)3.31186043
25Abnormality of the lower motor neuron (HP:0002366)3.29594674
26Urinary bladder sphincter dysfunction (HP:0002839)3.28858369
27Dysmetria (HP:0001310)3.20586806
28Abnormal eating behavior (HP:0100738)3.19982055
29Anxiety (HP:0000739)3.14527661
30Abnormal social behavior (HP:0012433)3.12482558
31Impaired social interactions (HP:0000735)3.12482558
32Genetic anticipation (HP:0003743)3.04072421
33Hemiplegia (HP:0002301)2.97839634
34Akinesia (HP:0002304)2.97829286
35Truncal ataxia (HP:0002078)2.96450995
36Ventricular fibrillation (HP:0001663)2.96315168
37Torticollis (HP:0000473)2.85773489
38Urinary urgency (HP:0000012)2.84201378
39Impaired smooth pursuit (HP:0007772)2.82751593
40Intention tremor (HP:0002080)2.82485667
41Amblyopia (HP:0000646)2.73828154
42Spastic gait (HP:0002064)2.72869979
43Diplopia (HP:0000651)2.71177991
44Abnormality of binocular vision (HP:0011514)2.71177991
45Bradykinesia (HP:0002067)2.69006033
46Focal dystonia (HP:0004373)2.67694399
47Hemiparesis (HP:0001269)2.66078363
48Peripheral hypomyelination (HP:0007182)2.62631578
49Progressive inability to walk (HP:0002505)2.60056910
50Scanning speech (HP:0002168)2.55065815
51Abnormality of ocular smooth pursuit (HP:0000617)2.53236511
52Sleep apnea (HP:0010535)2.52292847
53Hyperventilation (HP:0002883)2.51619556
54Megalencephaly (HP:0001355)2.49714398
55Diminished motivation (HP:0000745)2.48705873
56Choreoathetosis (HP:0001266)2.48056616
57Dysmetric saccades (HP:0000641)2.47348307
58Annular pancreas (HP:0001734)2.46538131
59Status epilepticus (HP:0002133)2.45433817
60Neurofibrillary tangles (HP:0002185)2.44408964
61Drooling (HP:0002307)2.43337504
62Excessive salivation (HP:0003781)2.43337504
63Spastic tetraparesis (HP:0001285)2.39897919
64Pheochromocytoma (HP:0002666)2.38463826
65Stereotypic behavior (HP:0000733)2.38259997
66Insomnia (HP:0100785)2.37239179
67Craniofacial dystonia (HP:0012179)2.36746502
68CNS hypomyelination (HP:0003429)2.35553223
69Bundle branch block (HP:0011710)2.35081916
70Cerebral inclusion bodies (HP:0100314)2.33866231
71Impaired vibratory sensation (HP:0002495)2.32771947
72Epileptiform EEG discharges (HP:0011182)2.26479999
73Lower limb muscle weakness (HP:0007340)2.26120337
74Agitation (HP:0000713)2.25965417
75EEG with generalized epileptiform discharges (HP:0011198)2.22583557
76Limb dystonia (HP:0002451)2.21596838
77Fetal akinesia sequence (HP:0001989)2.20897885
78Pointed chin (HP:0000307)2.20081332
79Abnormality of the corticospinal tract (HP:0002492)2.19649077
80Hypsarrhythmia (HP:0002521)2.15560866
81* Delusions (HP:0000746)2.15333809
82Generalized myoclonic seizures (HP:0002123)2.15093216
83Clonus (HP:0002169)2.13551999
84Polyphagia (HP:0002591)2.12581926
85Amyotrophic lateral sclerosis (HP:0007354)2.12137873
86Termporal pattern (HP:0011008)2.11372611
87Insidious onset (HP:0003587)2.11372611
88Morphological abnormality of the pyramidal tract (HP:0002062)2.07347062
89Degeneration of the lateral corticospinal tracts (HP:0002314)2.05099931
90Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.05099931
91Obstructive sleep apnea (HP:0002870)2.04363560
92Neuronal loss in central nervous system (HP:0002529)2.02786258
93Central scotoma (HP:0000603)2.01553460
94Abnormality of saccadic eye movements (HP:0000570)2.01229424
95Absent speech (HP:0001344)2.00880865
96Lower limb amyotrophy (HP:0007210)2.00825275
97Increased circulating renin level (HP:0000848)2.00198716
98Neuroendocrine neoplasm (HP:0100634)2.00002880
99Rigidity (HP:0002063)1.99973412
100Gait ataxia (HP:0002066)1.99451123
101Tetraplegia (HP:0002445)1.96146969
102Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.95547826
103Incomplete penetrance (HP:0003829)1.95298717
104Memory impairment (HP:0002354)1.93591706
105Inability to walk (HP:0002540)1.91862634
106Aplasia involving bones of the extremities (HP:0009825)1.88803512
107Aplasia involving bones of the upper limbs (HP:0009823)1.88803512
108Aplasia of the phalanges of the hand (HP:0009802)1.88803512
109Slow saccadic eye movements (HP:0000514)1.86976001
110Rapidly progressive (HP:0003678)1.84961568
111Resting tremor (HP:0002322)1.84668344
112Heart block (HP:0012722)1.84578775
113Unsteady gait (HP:0002317)1.84147292
114Psychosis (HP:0000709)1.83529029
115Split foot (HP:0001839)1.82975867
116Abnormal EKG (HP:0003115)1.82419767
117Apathy (HP:0000741)1.80224311
118Neoplasm of the peripheral nervous system (HP:0100007)1.79512539
119Lower limb asymmetry (HP:0100559)1.77815171
120Hypoventilation (HP:0002791)1.77295376
121Distal upper limb amyotrophy (HP:0007149)1.77248107
122Upper limb amyotrophy (HP:0009129)1.77248107
123Failure to thrive in infancy (HP:0001531)1.76511923
124Spinal canal stenosis (HP:0003416)1.74978437

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.25231068
2NTRK34.16362496
3EPHA43.66028989
4MARK13.18461684
5MAP3K42.98400965
6MINK12.87565135
7DAPK22.87279885
8PAK62.73280312
9PRKD32.52758414
10MAP2K72.41227506
11CAMKK12.25427228
12KSR22.20866172
13NTRK22.17213591
14MAP2K41.92509650
15MAP3K121.88490017
16NTRK11.82893927
17STK381.74868217
18CDK191.65561774
19CDK51.61905059
20DAPK11.59852324
21KSR11.42240201
22UHMK11.36859260
23PRPF4B1.35632420
24ARAF1.35554011
25RIPK41.35340861
26SIK21.31356028
27TYRO31.29537953
28PRKCG1.29369795
29TAOK11.28235476
30MAP3K21.24686448
31CASK1.20611488
32LATS21.20603498
33CAMKK21.19517916
34PHKG21.15736374
35PHKG11.15736374
36PINK11.15545992
37MAPK131.15092415
38ALK1.13125944
39PRKCH1.09636028
40CAMK11.09140256
41FES1.08881431
42STK111.04885053
43MAP3K131.04151627
44CDK151.03528845
45CDK181.03357656
46TNIK1.01536399
47CDK140.97142404
48PNCK0.96206249
49NEK10.95439231
50MAP3K110.94212073
51LMTK20.94138772
52SGK2230.92930943
53SGK4940.92930943
54CDK11A0.91434536
55RET0.89690832
56RIPK10.84929361
57CAMK2A0.84773010
58PAK30.81940508
59PKN10.75826208
60SGK30.75675540
61TNK20.74422470
62PDK10.73927406
63OXSR10.73782646
64RAF10.73163547
65BRAF0.70508699
66SGK20.70212205
67BRSK10.69487108
68DYRK1A0.69304460
69MARK20.66281705
70MAP3K10.65067434
71PDPK10.64444010
72SGK10.63128391
73TESK10.62634145
74SCYL20.62004798
75WNK10.61560797
76CAMK2B0.60465551
77CSNK1G20.59327256
78CDC42BPA0.58781892
79PTK2B0.57356938
80CAMK1G0.53859093
81RPS6KA30.53481112
82CAMK40.52893854
83PRKG20.52183417
84MAP3K70.51748282
85DAPK30.51554546
86PRKCZ0.51503179
87CCNB10.49216449
88NEK60.48435977
89CAMK2G0.46852189
90MAPK100.46087747
91FYN0.45136329
92FGFR20.42831681
93PRKCE0.38285977
94CAMK2D0.37165035
95BMPR20.35305825
96MAPKAPK50.35187805
97MAP2K10.34328689
98FER0.33866020
99TAOK20.33283806
100RPS6KA20.32472155
101MAPK120.32072582
102PRKCB0.32032125
103ROCK10.31512027
104IRAK20.30790632
105MAP2K60.30288635
106ROCK20.28713353
107PRKCA0.28227370
108MAPK40.27338254
109DDR20.27239291
110* GRK50.26988266
111ERBB20.26834802
112LIMK10.26728912
113MAPK80.25904042
114SRC0.23594222

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.72616191
2Nicotine addiction_Homo sapiens_hsa050333.51367908
3Olfactory transduction_Homo sapiens_hsa047402.78071090
4GABAergic synapse_Homo sapiens_hsa047272.76209143
5Circadian entrainment_Homo sapiens_hsa047132.65160270
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.54578828
7Long-term potentiation_Homo sapiens_hsa047202.54241495
8Glutamatergic synapse_Homo sapiens_hsa047242.53961743
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.48213023
10Morphine addiction_Homo sapiens_hsa050322.41015573
11Amphetamine addiction_Homo sapiens_hsa050312.28477437
12Salivary secretion_Homo sapiens_hsa049702.17273134
13Insulin secretion_Homo sapiens_hsa049112.09555586
14Dopaminergic synapse_Homo sapiens_hsa047282.06638027
15Gastric acid secretion_Homo sapiens_hsa049711.97116285
16Cholinergic synapse_Homo sapiens_hsa047251.88564291
17Vitamin B6 metabolism_Homo sapiens_hsa007501.87404996
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.85738405
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.72573005
20Nitrogen metabolism_Homo sapiens_hsa009101.66701320
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.63940461
22Taste transduction_Homo sapiens_hsa047421.61614685
23Oxytocin signaling pathway_Homo sapiens_hsa049211.60722800
24Long-term depression_Homo sapiens_hsa047301.60210397
25Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.52736582
26Renin secretion_Homo sapiens_hsa049241.50516237
27Cocaine addiction_Homo sapiens_hsa050301.48816078
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.46391461
29Calcium signaling pathway_Homo sapiens_hsa040201.44968469
30Serotonergic synapse_Homo sapiens_hsa047261.43348250
31GnRH signaling pathway_Homo sapiens_hsa049121.42653797
32Collecting duct acid secretion_Homo sapiens_hsa049661.40990873
33Phototransduction_Homo sapiens_hsa047441.33787199
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.28391878
35Gap junction_Homo sapiens_hsa045401.28252690
36Type II diabetes mellitus_Homo sapiens_hsa049301.25888402
37cAMP signaling pathway_Homo sapiens_hsa040241.23070436
38Estrogen signaling pathway_Homo sapiens_hsa049151.15264368
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14547930
40Glioma_Homo sapiens_hsa052141.13183013
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.05903675
42ErbB signaling pathway_Homo sapiens_hsa040120.99155028
43cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99020750
44Melanogenesis_Homo sapiens_hsa049160.97258404
45Cardiac muscle contraction_Homo sapiens_hsa042600.93141091
46Axon guidance_Homo sapiens_hsa043600.92964664
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.92140884
48Vibrio cholerae infection_Homo sapiens_hsa051100.90749321
49Oocyte meiosis_Homo sapiens_hsa041140.89467375
50Vascular smooth muscle contraction_Homo sapiens_hsa042700.83963874
51Phospholipase D signaling pathway_Homo sapiens_hsa040720.83677926
52Pancreatic secretion_Homo sapiens_hsa049720.82969369
53Thyroid hormone synthesis_Homo sapiens_hsa049180.82191812
54Dorso-ventral axis formation_Homo sapiens_hsa043200.81867169
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79948667
56Carbohydrate digestion and absorption_Homo sapiens_hsa049730.78784029
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71547967
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71524029
59Dilated cardiomyopathy_Homo sapiens_hsa054140.70605915
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69855720
61MAPK signaling pathway_Homo sapiens_hsa040100.67272805
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.65677155
63Bile secretion_Homo sapiens_hsa049760.65298854
64Choline metabolism in cancer_Homo sapiens_hsa052310.64613089
65Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62416796
66Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.61970512
67Endocytosis_Homo sapiens_hsa041440.59984133
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59669623
69VEGF signaling pathway_Homo sapiens_hsa043700.58457508
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57849954
71mTOR signaling pathway_Homo sapiens_hsa041500.57257628
72Glucagon signaling pathway_Homo sapiens_hsa049220.57082309
73Arginine and proline metabolism_Homo sapiens_hsa003300.54931582
74Type I diabetes mellitus_Homo sapiens_hsa049400.54928331
75Inositol phosphate metabolism_Homo sapiens_hsa005620.52222676
76Ras signaling pathway_Homo sapiens_hsa040140.51637843
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.49982094
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.49915608
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49529149
80Rap1 signaling pathway_Homo sapiens_hsa040150.48176361
81Endometrial cancer_Homo sapiens_hsa052130.46064806
82Alcoholism_Homo sapiens_hsa050340.45078453
83Insulin signaling pathway_Homo sapiens_hsa049100.44040241
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43990036
85Circadian rhythm_Homo sapiens_hsa047100.42849429
86Prion diseases_Homo sapiens_hsa050200.42804665
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42697291
88Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42629485
89Non-small cell lung cancer_Homo sapiens_hsa052230.40599810
90Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40127145
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39175757
92Renal cell carcinoma_Homo sapiens_hsa052110.38518468
93Histidine metabolism_Homo sapiens_hsa003400.38127307
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36498992
95Chemokine signaling pathway_Homo sapiens_hsa040620.34961735
96Mineral absorption_Homo sapiens_hsa049780.34671881
97Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32908613
98Wnt signaling pathway_Homo sapiens_hsa043100.32408052
99Ovarian steroidogenesis_Homo sapiens_hsa049130.32079288
100Arginine biosynthesis_Homo sapiens_hsa002200.31249885
101Alzheimers disease_Homo sapiens_hsa050100.31055353
102Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.29087205
103Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.28298686
104Central carbon metabolism in cancer_Homo sapiens_hsa052300.27662624
105HIF-1 signaling pathway_Homo sapiens_hsa040660.25985516
106Fatty acid biosynthesis_Homo sapiens_hsa000610.25130764
107Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.24406870
108beta-Alanine metabolism_Homo sapiens_hsa004100.22854991
109AMPK signaling pathway_Homo sapiens_hsa041520.21472594
1102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.21311053
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.17989701
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.17644472
113Tight junction_Homo sapiens_hsa045300.16863285

Most similar genes based on co-expression Upload to Enrichr

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