SNCG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the synuclein family of proteins which are believed to be involved in the pathogenesis of neurodegenerative diseases. Mutations in this gene have also been associated with breast tumor development. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sequestering of actin monomers (GO:0042989)7.75907265
2detection of temperature stimulus involved in sensory perception of pain (GO:0050965)6.76553790
3detection of temperature stimulus involved in sensory perception (GO:0050961)6.76553790
4detection of temperature stimulus (GO:0016048)6.57853509
5synaptic vesicle docking involved in exocytosis (GO:0016081)5.78895091
6cell migration in hindbrain (GO:0021535)5.75100086
7peripheral nervous system neuron development (GO:0048935)5.67675260
8negative regulation of microtubule polymerization (GO:0031115)5.36124477
9cerebellar granule cell differentiation (GO:0021707)5.33936643
10cellular potassium ion homeostasis (GO:0030007)5.26037489
11sodium ion export (GO:0071436)5.17845365
12response to pain (GO:0048265)5.09445489
13negative regulation of calcium ion transport into cytosol (GO:0010523)4.97916362
14mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.84527541
15membrane budding (GO:0006900)4.76737093
16protein neddylation (GO:0045116)4.67408725
17phenol-containing compound catabolic process (GO:0019336)4.64262357
18cerebellar Purkinje cell layer development (GO:0021680)4.57072643
19negative regulation of dendrite morphogenesis (GO:0050774)4.44805117
20neuronal action potential (GO:0019228)4.38772079
21short-term memory (GO:0007614)4.32365412
22chaperone-mediated protein transport (GO:0072321)4.20795892
23neurotransmitter secretion (GO:0007269)4.20502123
24cerebellar Purkinje cell differentiation (GO:0021702)4.18180479
25neuronal ion channel clustering (GO:0045161)4.15320045
26membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.13983742
27positive regulation of synaptic transmission, GABAergic (GO:0032230)4.09131387
28neuronal action potential propagation (GO:0019227)4.08658882
29behavioral response to pain (GO:0048266)4.07184935
30retinal ganglion cell axon guidance (GO:0031290)4.06940495
31ionotropic glutamate receptor signaling pathway (GO:0035235)4.04165990
32enteric nervous system development (GO:0048484)4.01797237
33neurofilament cytoskeleton organization (GO:0060052)4.01233491
34proline transport (GO:0015824)3.98724623
35respiratory electron transport chain (GO:0022904)3.97706204
36electron transport chain (GO:0022900)3.97039577
37positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.95745638
38cellular sodium ion homeostasis (GO:0006883)3.92831985
39neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.90304870
40gamma-aminobutyric acid signaling pathway (GO:0007214)3.90164907
41calcium-mediated signaling using intracellular calcium source (GO:0035584)3.89057666
42regulation of synaptic vesicle transport (GO:1902803)3.88373167
43prepulse inhibition (GO:0060134)3.86343684
44negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.86271703
45regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.80682978
46energy coupled proton transport, down electrochemical gradient (GO:0015985)3.79243893
47ATP synthesis coupled proton transport (GO:0015986)3.79243893
48negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.72913229
49cellular response to nicotine (GO:0071316)3.72068710
50mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.67624430
51layer formation in cerebral cortex (GO:0021819)3.65739742
52regulation of neuronal synaptic plasticity (GO:0048168)3.65220720
53detection of mechanical stimulus involved in sensory perception (GO:0050974)3.64528613
54synaptic transmission, glutamatergic (GO:0035249)3.64018852
55neuron-neuron synaptic transmission (GO:0007270)3.63741336
56potassium ion homeostasis (GO:0055075)3.60662254
57negative regulation of heart rate (GO:0010459)3.59730174
58exploration behavior (GO:0035640)3.59441587
59cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.57587858
60positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.52749454
61regulation of synapse structural plasticity (GO:0051823)3.48142480
62positive regulation of dendritic spine morphogenesis (GO:0061003)3.48047719
63positive regulation of synapse maturation (GO:0090129)3.44693542
64sympathetic nervous system development (GO:0048485)3.40383166
65cell differentiation in hindbrain (GO:0021533)3.39577568
66peroxisome fission (GO:0016559)3.39149708
67membrane depolarization during action potential (GO:0086010)3.38980628
68negative regulation of cation channel activity (GO:2001258)3.38264892
69synaptic vesicle endocytosis (GO:0048488)3.36696673
70positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.36687662
71membrane assembly (GO:0071709)3.36549762
72neurotransmitter transport (GO:0006836)3.35062815
73regulation of neurotransmitter levels (GO:0001505)3.32987754
74synaptic vesicle exocytosis (GO:0016079)3.32609564
75synaptic vesicle maturation (GO:0016188)3.32288729
76detection of calcium ion (GO:0005513)3.30133457
77positive regulation of dendritic spine development (GO:0060999)3.29969657
78regulation of synaptic plasticity (GO:0048167)3.27582554
79locomotory exploration behavior (GO:0035641)3.25081305
80behavioral response to nicotine (GO:0035095)3.25061103
81neuromuscular synaptic transmission (GO:0007274)3.25049109
82vocalization behavior (GO:0071625)3.25017986
83eating behavior (GO:0042755)3.23969276
84axon cargo transport (GO:0008088)3.22790605
85NADH metabolic process (GO:0006734)3.21756777
86sensory perception of pain (GO:0019233)3.20258360
87chemosensory behavior (GO:0007635)3.16479592
88glutamate receptor signaling pathway (GO:0007215)3.13576399
89protein maturation by protein folding (GO:0022417)3.13073220
90response to dietary excess (GO:0002021)3.12893778
91cytoskeletal anchoring at plasma membrane (GO:0007016)3.10183273
92negative regulation of protein polymerization (GO:0032272)3.09310950
93regulation of voltage-gated calcium channel activity (GO:1901385)3.08365025
94glutamate secretion (GO:0014047)3.04755380
95response to histamine (GO:0034776)3.04651678
96protein heterotetramerization (GO:0051290)3.04484283
97axon ensheathment in central nervous system (GO:0032291)3.03890071
98central nervous system myelination (GO:0022010)3.03890071
99hydrogen ion transmembrane transport (GO:1902600)3.03318965
100dopamine receptor signaling pathway (GO:0007212)3.03029124
101cell communication by electrical coupling (GO:0010644)3.02235668
102regulation of excitatory postsynaptic membrane potential (GO:0060079)3.01217258
103clathrin coat assembly (GO:0048268)2.98628524
104acylglycerol catabolic process (GO:0046464)2.98187720
105neutral lipid catabolic process (GO:0046461)2.98187720
106regulation of synapse maturation (GO:0090128)2.92968868
107membrane raft organization (GO:0031579)2.92321695
108positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.91880616
109positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.90872820
110regulation of short-term neuronal synaptic plasticity (GO:0048172)2.90746248
111regulation of long-term neuronal synaptic plasticity (GO:0048169)2.90701143
112cytidine catabolic process (GO:0006216)2.90255460
113cytidine deamination (GO:0009972)2.90255460
114cytidine metabolic process (GO:0046087)2.90255460
115negative regulation of amino acid transport (GO:0051956)2.89867541
116negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.88914389
117triglyceride catabolic process (GO:0019433)2.84603535
118negative regulation of dendrite development (GO:2000171)2.84191717
119ATP hydrolysis coupled proton transport (GO:0015991)2.83351325
120energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.83351325
121regulation of ARF protein signal transduction (GO:0032012)2.82850345
122regulation of dendritic spine morphogenesis (GO:0061001)2.81996242
123C4-dicarboxylate transport (GO:0015740)2.81672607
124multicellular organismal response to stress (GO:0033555)2.81287050
125response to insecticide (GO:0017085)2.80601145
126long-term memory (GO:0007616)2.79869256
127regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.79840634
128regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.79700227
129metanephric nephron epithelium development (GO:0072243)2.79626800
130regulation of postsynaptic membrane potential (GO:0060078)2.78013335
131urinary tract smooth muscle contraction (GO:0014848)2.77402975
132regulation of synaptic vesicle exocytosis (GO:2000300)2.74929990
133fructose metabolic process (GO:0006000)2.74859121
134acidic amino acid transport (GO:0015800)2.74487814
135* regulation of neurotransmitter secretion (GO:0046928)2.74330471
136endocrine hormone secretion (GO:0060986)2.73864401
137alanine transport (GO:0032328)2.73366812
138regulation of vesicle fusion (GO:0031338)2.72845896
139metanephric nephron tubule development (GO:0072234)2.72012165
140metanephric tubule development (GO:0072170)2.72012165
141regulation of amyloid precursor protein catabolic process (GO:1902991)2.70707096
142regulation of dopamine metabolic process (GO:0042053)2.70088894
143regulation of catecholamine metabolic process (GO:0042069)2.70088894
144regulation of protein kinase A signaling (GO:0010738)2.69977105
145establishment of mitochondrion localization (GO:0051654)2.69713320
146protein localization to synapse (GO:0035418)2.69711694
147neuromuscular process controlling balance (GO:0050885)2.68896127
148potassium ion import (GO:0010107)2.68087150
149membrane depolarization (GO:0051899)2.67799169
150regulation of histone phosphorylation (GO:0033127)2.66879020
151innervation (GO:0060384)2.66743188
152catecholamine transport (GO:0051937)2.66179642
153response to leptin (GO:0044321)2.66090917
154low-density lipoprotein particle clearance (GO:0034383)2.65477585
155auditory behavior (GO:0031223)2.65326153
156positive regulation of protein depolymerization (GO:1901881)2.65316797
157proton transport (GO:0015992)2.65083924
158long term synaptic depression (GO:0060292)2.64518357
159alkaloid metabolic process (GO:0009820)2.64253429
160regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.63967532
161negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.63446334
162phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.63125551
163dendritic spine organization (GO:0097061)2.63060858
164activation of protein kinase A activity (GO:0034199)2.62263171
165regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.62248720
166actin filament depolymerization (GO:0030042)2.62057005
167potassium ion export (GO:0071435)2.61839513
168regulation of cell communication by electrical coupling (GO:0010649)2.61766099
169behavioral response to ethanol (GO:0048149)2.61504760
170response to acidic pH (GO:0010447)2.61398180
171cell communication involved in cardiac conduction (GO:0086065)2.61130727
172action potential (GO:0001508)2.60594694
173hydrogen transport (GO:0006818)2.59519013
174cellular response to cadmium ion (GO:0071276)2.58508883
175positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.58492375
176synaptic transmission, cholinergic (GO:0007271)2.55171412
177negative regulation of calcium ion transmembrane transport (GO:1903170)2.55049130
178negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.55049130
179mating behavior (GO:0007617)2.54311300
180positive regulation of potassium ion transmembrane transport (GO:1901381)2.51685513
181adenosine metabolic process (GO:0046085)2.50660949

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.49412862
2ZNF263_19887448_ChIP-Seq_K562_Human3.97615739
3EZH2_22144423_ChIP-Seq_EOC_Human3.84199916
4JARID2_20075857_ChIP-Seq_MESCs_Mouse3.05214699
5TAF15_26573619_Chip-Seq_HEK293_Human3.00484267
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.97314715
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.82692042
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.66933181
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.66933181
10BMI1_23680149_ChIP-Seq_NPCS_Mouse2.66799851
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.60315101
12EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.60146856
13ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.51540447
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.50852620
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.49653980
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.45713433
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.43783656
18NR3C1_23031785_ChIP-Seq_PC12_Mouse2.40456112
19CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.37019149
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.36047630
21SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.31708605
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.22442998
23REST_21632747_ChIP-Seq_MESCs_Mouse2.15068823
24EED_16625203_ChIP-ChIP_MESCs_Mouse2.12718275
25EZH2_27294783_Chip-Seq_ESCs_Mouse2.00808810
26ERG_21242973_ChIP-ChIP_JURKAT_Human1.98024533
27REST_18959480_ChIP-ChIP_MESCs_Mouse1.92135953
28SUZ12_27294783_Chip-Seq_ESCs_Mouse1.90704071
29TRIM28_21343339_ChIP-Seq_HEK293_Human1.87365978
30MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.87059768
31WT1_19549856_ChIP-ChIP_CCG9911_Human1.86168900
32TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.85399438
33LXR_22292898_ChIP-Seq_THP-1_Human1.84087457
34PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.78728434
35TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63717603
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.61835195
37PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.61032944
38ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.59125638
39EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.59007993
40OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.53106155
41RNF2_27304074_Chip-Seq_ESCs_Mouse1.52883007
42WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.52840914
43FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.49643824
44ESR2_21235772_ChIP-Seq_MCF-7_Human1.48671091
45RACK7_27058665_Chip-Seq_MCF-7_Human1.47045555
46RBPJ_22232070_ChIP-Seq_NCS_Mouse1.45077762
47RARG_19884340_ChIP-ChIP_MEFs_Mouse1.41085980
48SMC4_20622854_ChIP-Seq_HELA_Human1.38181907
49SMAD4_21799915_ChIP-Seq_A2780_Human1.38080238
50ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.37640130
51RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.37549954
52GBX2_23144817_ChIP-Seq_PC3_Human1.37545129
53* CTCF_27219007_Chip-Seq_Bcells_Human1.37169215
54CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35403997
55CLOCK_20551151_ChIP-Seq_293T_Human1.34357108
56* PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.31221191
57SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.29714752
58CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.28815034
59SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.28642179
60KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.28641689
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26649159
62SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.26586090
63P300_19829295_ChIP-Seq_ESCs_Human1.26093546
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.25307213
65TP53_20018659_ChIP-ChIP_R1E_Mouse1.23199794
66IKZF1_21737484_ChIP-ChIP_HCT116_Human1.22782255
67* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.21490155
68* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.21159137
69CTBP1_25329375_ChIP-Seq_LNCAP_Human1.20900693
70TET1_21451524_ChIP-Seq_MESCs_Mouse1.20260995
71BCAT_22108803_ChIP-Seq_LS180_Human1.18185872
72OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17517629
73ETV2_25802403_ChIP-Seq_MESCs_Mouse1.16915199
74RARB_27405468_Chip-Seq_BRAIN_Mouse1.16551081
75UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16416873
76* P68_20966046_ChIP-Seq_HELA_Human1.13444139
77SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.12437186
78BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.12116088
79TP63_17297297_ChIP-ChIP_HaCaT_Human1.11739760
80CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.11467900
81SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11026098
82SALL1_21062744_ChIP-ChIP_HESCs_Human1.10623538
83POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.09442594
84GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.09101016
85ZNF274_21170338_ChIP-Seq_K562_Hela1.08594118
86ESR1_20079471_ChIP-ChIP_T-47D_Human1.07586388
87KDM2B_26808549_Chip-Seq_SUP-B15_Human1.07386753
88CREB1_26743006_Chip-Seq_LNCaP_Human1.07166280
89VDR_22108803_ChIP-Seq_LS180_Human1.06385371
90TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05744823
91CTCF_18555785_ChIP-Seq_MESCs_Mouse1.05516226
92* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05494685
93SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.04565395
94EGR1_19032775_ChIP-ChIP_M12_Human1.01342221
95TET1_21490601_ChIP-Seq_MESCs_Mouse1.01130416
96SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00630644
97THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.00266510
98FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.99100431
99SOX2_19829295_ChIP-Seq_ESCs_Human0.98751428
100NANOG_19829295_ChIP-Seq_ESCs_Human0.98751428
101HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.98519779
102EP300_21415370_ChIP-Seq_HL-1_Mouse0.98020469
103ESR1_21235772_ChIP-Seq_MCF-7_Human0.97892893
104AHR_22903824_ChIP-Seq_MCF-7_Human0.97519504
105TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.97216055
106RNF2_27304074_Chip-Seq_NSC_Mouse0.96402018
107TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96216817
108ZFP281_27345836_Chip-Seq_ESCs_Mouse0.96190425
109CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.95750375
110* SA1_27219007_Chip-Seq_ERYTHROID_Human0.95705592
111AR_25329375_ChIP-Seq_VCAP_Human0.95265962
112CBX2_27304074_Chip-Seq_ESCs_Mouse0.94812410
113CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.92620545
114MYC_19915707_ChIP-ChIP_AK7_Human0.92012731
115* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.90278209
116PIAS1_25552417_ChIP-Seq_VCAP_Human0.90097726
117ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.89652333
118JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.89420118
119* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.88914931
120JUN_21703547_ChIP-Seq_K562_Human0.88550686
121TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.87464466
122PRDM14_20953172_ChIP-Seq_ESCs_Human0.87355220
123SMAD4_21741376_ChIP-Seq_HESCs_Human0.87076399
124YY1_22570637_ChIP-Seq_MALME-3M_Human0.86562594
125NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.86544890
126CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.86203006
127PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.85331593
128DNAJC2_21179169_ChIP-ChIP_NT2_Human0.85331475
129SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.85142922
130* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.84958663
131SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.84404561
132MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.83761225
133SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.81018100
134SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.80936901
135ZFP281_18757296_ChIP-ChIP_E14_Mouse0.80002225
136DROSHA_22980978_ChIP-Seq_HELA_Human0.79944494
137PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.79814328
138SA1_27219007_Chip-Seq_Bcells_Human0.79431115
139RING1B_27294783_Chip-Seq_NPCs_Mouse0.79321357
140SOX2_21211035_ChIP-Seq_LN229_Gbm0.78878858
141KDM2B_26808549_Chip-Seq_K562_Human0.78524686
142SRY_22984422_ChIP-ChIP_TESTIS_Rat0.78408928
143RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.77676062
144SMAD3_21741376_ChIP-Seq_ESCs_Human0.77456380
145STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.76788363
146RING1B_27294783_Chip-Seq_ESCs_Mouse0.76721490
147ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.76677014
148NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.76316937

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002735_abnormal_chemical_nociception6.63182388
2MP0001968_abnormal_touch/_nociception5.56270166
3MP0002736_abnormal_nociception_after5.07517087
4MP0004270_analgesia4.66601425
5MP0002733_abnormal_thermal_nociception4.50458656
6MP0006276_abnormal_autonomic_nervous4.11534241
7MP0002734_abnormal_mechanical_nocicepti4.04277375
8MP0001986_abnormal_taste_sensitivity4.03559223
9MP0001970_abnormal_pain_threshold4.01409808
10MP0004858_abnormal_nervous_system3.54939904
11MP0004859_abnormal_synaptic_plasticity3.13970234
12MP0002822_catalepsy3.07456725
13MP0005670_abnormal_white_adipose2.83836007
14MP0002751_abnormal_autonomic_nervous2.48499556
15MP0010386_abnormal_urinary_bladder2.43105615
16MP0009780_abnormal_chondrocyte_physiolo2.42426669
17MP0009379_abnormal_foot_pigmentation2.31974205
18MP0002638_abnormal_pupillary_reflex2.30980244
19MP0002184_abnormal_innervation2.19246456
20MP0005666_abnormal_adipose_tissue2.04183932
21MP0002272_abnormal_nervous_system2.03525809
22MP0001905_abnormal_dopamine_level1.89949516
23MP0001440_abnormal_grooming_behavior1.89367848
24MP0002067_abnormal_sensory_capabilities1.80115003
25MP0003635_abnormal_synaptic_transmissio1.78439312
26MP0009745_abnormal_behavioral_response1.77890031
27MP0002064_seizures1.67119972
28MP0010234_abnormal_vibrissa_follicle1.64598602
29MP0002837_dystrophic_cardiac_calcinosis1.63429721
30MP0000372_irregular_coat_pigmentation1.62642278
31MP0005083_abnormal_biliary_tract1.61069461
32MP0000566_synostosis1.60609763
33MP0003690_abnormal_glial_cell1.60129811
34MP0005375_adipose_tissue_phenotype1.54079974
35MP0003880_abnormal_central_pattern1.49630343
36MP0000955_abnormal_spinal_cord1.47570413
37MP0002572_abnormal_emotion/affect_behav1.43867225
38MP0001529_abnormal_vocalization1.42912939
39MP0003656_abnormal_erythrocyte_physiolo1.37826194
40MP0003011_delayed_dark_adaptation1.36926925
41MP0000751_myopathy1.35409711
42MP0000003_abnormal_adipose_tissue1.34640898
43MP0003123_paternal_imprinting1.32664035
44MP0001270_distended_abdomen1.30204855
45MP0000538_abnormal_urinary_bladder1.30176824
46* MP0004811_abnormal_neuron_physiology1.24344218
47MP0006035_abnormal_mitochondrial_morpho1.23785229
48MP0009046_muscle_twitch1.20491129
49MP0002063_abnormal_learning/memory/cond1.19272330
50MP0004924_abnormal_behavior1.19001948
51MP0005386_behavior/neurological_phenoty1.19001948
52MP0008875_abnormal_xenobiotic_pharmacok1.17466895
53MP0002971_abnormal_brown_adipose1.12921521
54MP0005167_abnormal_blood-brain_barrier1.10367192
55MP0003137_abnormal_impulse_conducting1.08969847
56MP0001177_atelectasis1.07398845
57MP0004185_abnormal_adipocyte_glucose1.06226108
58MP0000013_abnormal_adipose_tissue1.04491809
59MP0000778_abnormal_nervous_system1.03136193
60* MP0002882_abnormal_neuron_morphology1.01952454
61MP0005646_abnormal_pituitary_gland1.00699740
62MP0008872_abnormal_physiological_respon0.99787030
63MP0001348_abnormal_lacrimal_gland0.97933887
64MP0005535_abnormal_body_temperature0.97023099
65MP0001501_abnormal_sleep_pattern0.96983188
66MP0004215_abnormal_myocardial_fiber0.96596372
67MP0005408_hypopigmentation0.92495995
68MP0006036_abnormal_mitochondrial_physio0.90494682
69MP0002752_abnormal_somatic_nervous0.89981700
70MP0004145_abnormal_muscle_electrophysio0.88351277
71MP0005423_abnormal_somatic_nervous0.88140288
72MP0002909_abnormal_adrenal_gland0.87718447
73MP0005623_abnormal_meninges_morphology0.85344177
74MP0002066_abnormal_motor_capabilities/c0.85182694
75MP0003122_maternal_imprinting0.83825683
76MP0010329_abnormal_lipoprotein_level0.83444948
77MP0003633_abnormal_nervous_system0.83164037
78MP0002796_impaired_skin_barrier0.83153132
79MP0002557_abnormal_social/conspecific_i0.81028068
80MP0001984_abnormal_olfaction0.79435642
81MP0003329_amyloid_beta_deposits0.79113006
82MP0003879_abnormal_hair_cell0.79039457
83MP0002876_abnormal_thyroid_physiology0.78915256
84MP0002229_neurodegeneration0.78815924
85MP0002152_abnormal_brain_morphology0.78274261
86MP0004142_abnormal_muscle_tone0.78164121
87MP0003191_abnormal_cellular_cholesterol0.78130265
88MP0006138_congestive_heart_failure0.76185238
89MP0000749_muscle_degeneration0.76074203
90MP0003634_abnormal_glial_cell0.75113666
91MP0002160_abnormal_reproductive_system0.74454569
92MP0000639_abnormal_adrenal_gland0.74441832
93MP0001756_abnormal_urination0.73513832
94MP0005334_abnormal_fat_pad0.73100408
95MP0008569_lethality_at_weaning0.73041652
96MP0004484_altered_response_of0.69110799
97MP0003075_altered_response_to0.68937725
98MP0003631_nervous_system_phenotype0.67711309
99* MP0008874_decreased_physiological_sensi0.67703309
100MP0000747_muscle_weakness0.67312879
101MP0001727_abnormal_embryo_implantation0.66214994
102MP0003959_abnormal_lean_body0.64987418
103MP0001346_abnormal_lacrimal_gland0.64554795
104MP0003705_abnormal_hypodermis_morpholog0.64517448
105MP0004883_abnormal_blood_vessel0.63949779
106MP0001664_abnormal_digestion0.62742662
107MP0001188_hyperpigmentation0.62391939
108MP0001486_abnormal_startle_reflex0.61632592
109MP0002970_abnormal_white_adipose0.61139218
110MP0003787_abnormal_imprinting0.59598615
111MP0004782_abnormal_surfactant_physiolog0.58721860
112MP0001299_abnormal_eye_distance/0.58290083
113MP0005448_abnormal_energy_balance0.57488096
114MP0001765_abnormal_ion_homeostasis0.56050414
115MP0002118_abnormal_lipid_homeostasis0.55911164
116MP0004036_abnormal_muscle_relaxation0.55178517
117MP0004742_abnormal_vestibular_system0.52455807
118MP0004130_abnormal_muscle_cell0.52446793
119MP0000534_abnormal_ureter_morphology0.52330355
120MP0004085_abnormal_heartbeat0.52001803
121MP0001963_abnormal_hearing_physiology0.51773155
122MP0000427_abnormal_hair_cycle0.51248148
123MP0002069_abnormal_eating/drinking_beha0.50654309
124MP0003868_abnormal_feces_composition0.49837106
125MP0002938_white_spotting0.49256753
126MP0003045_fibrosis0.48179838
127MP0008961_abnormal_basal_metabolism0.47056037
128MP0000230_abnormal_systemic_arterial0.46172594
129MP0005409_darkened_coat_color0.44935131
130MP0003693_abnormal_embryo_hatching0.44724212
131MP0002090_abnormal_vision0.44314836
132MP0000759_abnormal_skeletal_muscle0.42726574
133MP0003183_abnormal_peptide_metabolism0.42655139
134MP0008260_abnormal_autophagy0.42484907
135MP0005171_absent_coat_pigmentation0.40036094
136MP0000920_abnormal_myelination0.39131875
137MP0010771_integument_phenotype0.39054139
138MP0008775_abnormal_heart_ventricle0.38627258
139MP0001502_abnormal_circadian_rhythm0.38246878
140MP0000579_abnormal_nail_morphology0.37933347

Predicted human phenotypes

RankGene SetZ-score
1Myotonia (HP:0002486)6.91811258
2Hypothermia (HP:0002045)6.62098070
3Pheochromocytoma (HP:0002666)4.93120364
4Epileptic encephalopathy (HP:0200134)4.76074411
5Neuroendocrine neoplasm (HP:0100634)4.62827854
6Ulnar claw (HP:0001178)4.53638334
7Sensory axonal neuropathy (HP:0003390)4.48774964
8Impaired pain sensation (HP:0007328)3.99087512
9Abnormality of pain sensation (HP:0010832)3.99087512
10Scanning speech (HP:0002168)3.97726450
11Abnormal autonomic nervous system physiology (HP:0012332)3.96883126
12Limb dystonia (HP:0002451)3.95637437
13Truncal ataxia (HP:0002078)3.87823653
14Termporal pattern (HP:0011008)3.84122527
15Insidious onset (HP:0003587)3.84122527
16Intention tremor (HP:0002080)3.74307880
17Dysmetric saccades (HP:0000641)3.69245081
18Action tremor (HP:0002345)3.66759494
19Dysmetria (HP:0001310)3.60257396
20Acute necrotizing encephalopathy (HP:0006965)3.59777068
21Dysautonomia (HP:0002459)3.42960224
22Impaired vibration sensation in the lower limbs (HP:0002166)3.40374141
23Dysdiadochokinesis (HP:0002075)3.35427338
24Orthostatic hypotension (HP:0001278)3.31098647
25Abnormal eating behavior (HP:0100738)3.27093415
26Progressive macrocephaly (HP:0004481)3.18897106
27Abnormal hemoglobin (HP:0011902)3.14363188
28Abnormal mitochondria in muscle tissue (HP:0008316)3.10458192
29Focal seizures (HP:0007359)3.08536239
30Mitochondrial inheritance (HP:0001427)3.02460339
31Hypercortisolism (HP:0001578)2.99744861
32Febrile seizures (HP:0002373)2.97183455
33Foot dorsiflexor weakness (HP:0009027)2.96466269
34Muscle stiffness (HP:0003552)2.90304138
35Horizontal nystagmus (HP:0000666)2.89587511
36Atonic seizures (HP:0010819)2.88042627
37Hypoventilation (HP:0002791)2.84861367
38Neoplasm of the peripheral nervous system (HP:0100007)2.83420971
39Amblyopia (HP:0000646)2.83311711
40Neurofibrillary tangles (HP:0002185)2.83228415
41Progressive cerebellar ataxia (HP:0002073)2.82637022
42Acute encephalopathy (HP:0006846)2.82585954
43Akinesia (HP:0002304)2.81672360
44Failure to thrive in infancy (HP:0001531)2.78225361
45Diplopia (HP:0000651)2.77060178
46Abnormality of binocular vision (HP:0011514)2.77060178
47Acanthosis nigricans (HP:0000956)2.74016056
48Abnormality of the vocal cords (HP:0008777)2.70028307
49Distal arthrogryposis (HP:0005684)2.69302508
50Oligomenorrhea (HP:0000876)2.67167664
51Cerebral inclusion bodies (HP:0100314)2.63425442
52Postural tremor (HP:0002174)2.62498631
53Mutism (HP:0002300)2.61029009
54Cerebral hemorrhage (HP:0001342)2.60650322
55Visual hallucinations (HP:0002367)2.59382864
56Abnormality of the foot musculature (HP:0001436)2.57094674
57Depression (HP:0000716)2.56244588
58Polyphagia (HP:0002591)2.55847962
59Growth hormone excess (HP:0000845)2.55382663
60Abnormality of saccadic eye movements (HP:0000570)2.53971032
61Hepatocellular necrosis (HP:0001404)2.49090058
62Cerebral hypomyelination (HP:0006808)2.47444187
63Impaired smooth pursuit (HP:0007772)2.45141816
64Hypokinesia (HP:0002375)2.44179515
65Spastic gait (HP:0002064)2.43948484
66Postural instability (HP:0002172)2.43469579
67Focal motor seizures (HP:0011153)2.41388205
68Increased CSF lactate (HP:0002490)2.39941463
69Supranuclear gaze palsy (HP:0000605)2.39450072
70Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.39071293
71Rigidity (HP:0002063)2.38675735
72Renal salt wasting (HP:0000127)2.38436619
73Neuroblastoma (HP:0003006)2.36222528
74Primitive neuroectodermal tumor (HP:0030065)2.36222528
75Neuroblastic tumors (HP:0004376)2.36222528
76Peripheral primitive neuroectodermal neoplasm (HP:0030067)2.36222528
77Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.35719968
78Abnormal hair whorl (HP:0010721)2.33962512
79Gaze-evoked nystagmus (HP:0000640)2.31321793
80Autoamputation (HP:0001218)2.29558581
81Status epilepticus (HP:0002133)2.28827672
82Hammertoe (HP:0001765)2.28325070
83Ankle clonus (HP:0011448)2.25771351
84Exotropia (HP:0000577)2.23986330
85Abnormality of the corticospinal tract (HP:0002492)2.22868892
86Hyporeflexia of lower limbs (HP:0002600)2.21893327
87Aplasia/Hypoplasia of the brainstem (HP:0007362)2.20956704
88Hypoplasia of the brainstem (HP:0002365)2.20956704
89Abnormality of glycolysis (HP:0004366)2.20941746
90Abnormality of aromatic amino acid family metabolism (HP:0004338)2.19515719
91Steppage gait (HP:0003376)2.18328186
92Segmental peripheral demyelination/remyelination (HP:0003481)2.16871775
93Broad-based gait (HP:0002136)2.16325095
94Neuronal loss in central nervous system (HP:0002529)2.16075270
95Absence seizures (HP:0002121)2.15338468
96Craniofacial dystonia (HP:0012179)2.15246689
97Bradykinesia (HP:0002067)2.15000519
98Thyroid carcinoma (HP:0002890)2.14854167
99Distal upper limb amyotrophy (HP:0007149)2.14603411
100Upper limb amyotrophy (HP:0009129)2.14603411
101Optic disc pallor (HP:0000543)2.14465464
102Delusions (HP:0000746)2.14163785
103Hyperthyroidism (HP:0000836)2.13188441
104Popliteal pterygium (HP:0009756)2.12632585
105Potter facies (HP:0002009)2.12408670
106Facial shape deformation (HP:0011334)2.12408670
107Aplasia involving bones of the extremities (HP:0009825)2.10368284
108Aplasia involving bones of the upper limbs (HP:0009823)2.10368284
109Aplasia of the phalanges of the hand (HP:0009802)2.10368284
110Gait ataxia (HP:0002066)2.09993832
111Limb ataxia (HP:0002070)2.08490438
112Tetraplegia (HP:0002445)2.08242734
113Abnormality of magnesium homeostasis (HP:0004921)2.06627552
114Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.06593206
115Degeneration of the lateral corticospinal tracts (HP:0002314)2.06593206
116Lower limb amyotrophy (HP:0007210)2.06509235
117Torticollis (HP:0000473)2.06365222
118Morphological abnormality of the pyramidal tract (HP:0002062)2.06078483
119Increased hepatocellular lipid droplets (HP:0006565)2.05670944
120Cerebral edema (HP:0002181)2.05172230
121Generalized tonic-clonic seizures (HP:0002069)2.04977397
122Bradycardia (HP:0001662)2.04933506
123Epileptiform EEG discharges (HP:0011182)2.03676507
124Slow progression (HP:0003677)2.02611554
125Lower limb muscle weakness (HP:0007340)2.01038775
126Dialeptic seizures (HP:0011146)2.00297349
127Urinary urgency (HP:0000012)2.00185309
128Myokymia (HP:0002411)11.3476871
129Retinal dysplasia (HP:0007973)1.99854370
130Clonus (HP:0002169)1.98420611
131Abnormality of calcium-phosphate metabolism (HP:0100530)1.97928023
132Increased serum pyruvate (HP:0003542)1.97161295
133Diminished movement (HP:0002374)1.96286712
134Decreased activity of mitochondrial respiratory chain (HP:0008972)1.96093514
135Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.96093514
136Incomplete penetrance (HP:0003829)1.95972155
137Hepatic necrosis (HP:0002605)1.95793277
138Urinary bladder sphincter dysfunction (HP:0002839)1.95781910
139Focal dystonia (HP:0004373)1.95587869
140Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.94701740
141Abnormality of ocular smooth pursuit (HP:0000617)1.92930986
142Hand muscle atrophy (HP:0009130)1.92135107
143Hypomagnesemia (HP:0002917)1.92071348
144Impaired vibratory sensation (HP:0002495)1.91523040
145Anxiety (HP:0000739)1.91213417
146Poor eye contact (HP:0000817)1.90370096
147Poor suck (HP:0002033)1.89304912
148Rapidly progressive (HP:0003678)1.88410101
149Hemiplegia (HP:0002301)1.88215064
150Respiratory failure (HP:0002878)1.87828175
151Distal sensory impairment (HP:0002936)1.87423199
152Areflexia of lower limbs (HP:0002522)1.84567725
153Palpitations (HP:0001962)1.84541412
154Athetosis (HP:0002305)1.83312268
155EEG with generalized epileptiform discharges (HP:0011198)1.81997288
156Abnormality of the lower motor neuron (HP:0002366)1.81619075
157Lipid accumulation in hepatocytes (HP:0006561)1.80727794
158Leukodystrophy (HP:0002415)1.80662728
159Neonatal onset (HP:0003623)1.80356201
160Axonal loss (HP:0003447)1.79918023
161Menstrual irregularities (HP:0000858)1.79284871
162Agitation (HP:0000713)1.78931105
163Abnormal gallbladder physiology (HP:0012438)1.77241035
164Cholecystitis (HP:0001082)1.77241035
165Hypertriglyceridemia (HP:0002155)1.75491616
166Obstructive sleep apnea (HP:0002870)1.73364303
167Annular pancreas (HP:0001734)1.73360179
168CNS hypomyelination (HP:0003429)1.72091397

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK13.94603568
2LIMK13.93270692
3KSR23.80911348
4EPHA43.75170088
5MAP3K23.65663890
6ARAF3.40061217
7NME23.22785062
8MAP3K123.19174391
9MAP3K93.17065369
10NTRK32.67029440
11MINK12.20621481
12LMTK22.07566540
13RIPK12.03516146
14TESK12.01751928
15MST1R2.00455437
16DAPK21.98908872
17RET1.97801266
18EPHA21.92054560
19MATK1.90605302
20BMPR1B1.88700255
21TRIB31.80054590
22PIM21.69806462
23MAP2K11.59113525
24MAPK131.57698884
25PRKD31.57559301
26LATS21.49224424
27CAMK11.47296926
28ADRBK11.46571334
29NME11.41526777
30RIPK41.35781456
31GRK71.34311810
32SIK11.32472319
33UHMK11.31140865
34MAPKAPK51.28254456
35MAP2K21.24384884
36PHKG21.21226239
37PHKG11.21226239
38MAP2K41.21200392
39EPHA31.19803821
40MAPKAPK31.19593181
41TIE11.17426156
42MAP3K11.15910798
43PTK2B1.13714646
44EPHB21.10557346
45* GRK51.09799950
46CSNK1G31.09294820
47MET1.07189126
48PRKG21.06465704
49MARK11.03255346
50CDK141.03061851
51RPS6KA21.02305864
52MAP3K110.98149439
53FER0.97983293
54DDR20.97003927
55MYLK0.96229567
56PLK20.92665370
57SIK30.92611549
58MARK20.90989805
59STK390.90473256
60MAP3K130.90104091
61MAP3K40.87985366
62CSNK1G20.87736833
63CASK0.86680878
64CAMKK20.85355300
65PNCK0.84933420
66TYRO30.84415121
67TESK20.84128944
68PAK40.83589521
69PAK60.82475300
70CDK50.80390708
71MAPK120.78947910
72WNK40.78680955
73BRAF0.78517308
74MAP2K70.75931148
75SGK4940.74497263
76SGK2230.74497263
77ADRBK20.73412772
78PDK10.71931552
79PKN20.71817649
80CDK180.70279036
81MST40.68347099
82PTK20.67841928
83ROCK20.67137670
84CDK150.66903443
85MARK30.65529891
86CSNK1G10.64296027
87DAPK10.64010185
88NEK60.62833315
89PRKCE0.62426627
90CDK11A0.61469805
91PDPK10.60686181
92PTK60.57686909
93DAPK30.57620017
94HIPK20.56684538
95LRRK20.56661842
96BRSK10.54715852
97CDK80.53943367
98PRKG10.53228691
99MAPK40.52849459
100RPS6KA30.52651073
101ERN10.51565163
102STK380.51058261
103PRPF4B0.50268677
104PRKACA0.50105704
105WNK10.49771375
106DYRK20.48678070
107CAMK2G0.47727830
108BMPR20.47258185
109CAMK2B0.47226809
110MAPK100.46596179
111CSNK1A1L0.45720668
112PRKCG0.44971909
113BMX0.43999531
114NEK10.43769423
115PRKCH0.43404241
116CAMK2A0.43059070
117PRKCA0.40359381
118ALK0.39322893
119FYN0.39257880
120PKN10.38979655
121PRKACG0.38448719
122RAF10.38012823
123SGK20.36963519
124ABL20.35292744
125ILK0.34469101
126CAMK2D0.33911455
127TNK20.33258962
128TAOK10.32756230
129NTRK20.30115351
130TGFBR10.29651571
131PAK10.29095743
132SRC0.28893104
133PINK10.27878821
134PAK30.27402581
135CAMKK10.27269039
136PRKCZ0.26466658
137SCYL20.25761312
138SIK20.25699559
139AURKA0.25572706

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.97690730
2Parkinsons disease_Homo sapiens_hsa050124.64704346
3Alzheimers disease_Homo sapiens_hsa050103.39149616
4Synaptic vesicle cycle_Homo sapiens_hsa047213.37429594
5Huntingtons disease_Homo sapiens_hsa050162.96709519
6Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.92781185
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.69866362
8Cardiac muscle contraction_Homo sapiens_hsa042602.64610476
9Collecting duct acid secretion_Homo sapiens_hsa049662.54337855
10Ribosome_Homo sapiens_hsa030102.44034675
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.42673773
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.65722159
13Cholinergic synapse_Homo sapiens_hsa047251.60363129
14Thyroid cancer_Homo sapiens_hsa052161.54237646
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.54082951
16Dopaminergic synapse_Homo sapiens_hsa047281.49597534
17Proteasome_Homo sapiens_hsa030501.48319658
18Serotonergic synapse_Homo sapiens_hsa047261.43115887
19Taste transduction_Homo sapiens_hsa047421.42173566
20Tyrosine metabolism_Homo sapiens_hsa003501.40701040
21Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.40410188
22Vibrio cholerae infection_Homo sapiens_hsa051101.40049768
23Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.39813946
24Nitrogen metabolism_Homo sapiens_hsa009101.38512443
25Vitamin B6 metabolism_Homo sapiens_hsa007501.30577664
26Olfactory transduction_Homo sapiens_hsa047401.29308739
27Insulin secretion_Homo sapiens_hsa049111.26809083
28Dorso-ventral axis formation_Homo sapiens_hsa043201.21618664
29Circadian entrainment_Homo sapiens_hsa047131.16333802
30Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.12483069
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.12027262
32Phenylalanine metabolism_Homo sapiens_hsa003601.11898614
33Long-term potentiation_Homo sapiens_hsa047201.10325075
34Glutamatergic synapse_Homo sapiens_hsa047241.08924078
35Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.07512424
36Regulation of autophagy_Homo sapiens_hsa041401.05246763
37SNARE interactions in vesicular transport_Homo sapiens_hsa041301.04808743
38Salivary secretion_Homo sapiens_hsa049700.99568466
39Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.99237175
40Fatty acid biosynthesis_Homo sapiens_hsa000610.97138441
41Amphetamine addiction_Homo sapiens_hsa050310.96772165
42GnRH signaling pathway_Homo sapiens_hsa049120.93239508
43cAMP signaling pathway_Homo sapiens_hsa040240.91086114
44Long-term depression_Homo sapiens_hsa047300.90023926
45Pyruvate metabolism_Homo sapiens_hsa006200.87711389
46PPAR signaling pathway_Homo sapiens_hsa033200.87479196
47Pentose phosphate pathway_Homo sapiens_hsa000300.87255426
48GABAergic synapse_Homo sapiens_hsa047270.86370175
49Gap junction_Homo sapiens_hsa045400.86172390
50Cocaine addiction_Homo sapiens_hsa050300.82954235
51Phagosome_Homo sapiens_hsa041450.81271974
52Rheumatoid arthritis_Homo sapiens_hsa053230.79063206
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78428689
54Renin secretion_Homo sapiens_hsa049240.74923644
55Glioma_Homo sapiens_hsa052140.73665606
56Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.73556878
57Insulin signaling pathway_Homo sapiens_hsa049100.73418860
58Morphine addiction_Homo sapiens_hsa050320.70104502
59VEGF signaling pathway_Homo sapiens_hsa043700.69114443
60Steroid biosynthesis_Homo sapiens_hsa001000.67878836
61Melanoma_Homo sapiens_hsa052180.66843925
62Carbon metabolism_Homo sapiens_hsa012000.66548036
63beta-Alanine metabolism_Homo sapiens_hsa004100.66064456
64Estrogen signaling pathway_Homo sapiens_hsa049150.64207671
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.63985624
66Biosynthesis of amino acids_Homo sapiens_hsa012300.63690582
67Ovarian steroidogenesis_Homo sapiens_hsa049130.62242652
68Glucagon signaling pathway_Homo sapiens_hsa049220.60524193
69Primary bile acid biosynthesis_Homo sapiens_hsa001200.60506174
70Sulfur relay system_Homo sapiens_hsa041220.60045099
71Central carbon metabolism in cancer_Homo sapiens_hsa052300.59925378
72Arginine and proline metabolism_Homo sapiens_hsa003300.59497592
73AMPK signaling pathway_Homo sapiens_hsa041520.59417415
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59410241
75Gastric acid secretion_Homo sapiens_hsa049710.58146988
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57388595
77Melanogenesis_Homo sapiens_hsa049160.57329076
78Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55367631
79Phototransduction_Homo sapiens_hsa047440.54889730
80Oxytocin signaling pathway_Homo sapiens_hsa049210.54875934
81Glycerolipid metabolism_Homo sapiens_hsa005610.54304235
82Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53341721
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.53098017
84Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52931122
85Nicotine addiction_Homo sapiens_hsa050330.51318643
86Mineral absorption_Homo sapiens_hsa049780.51102769
87Circadian rhythm_Homo sapiens_hsa047100.50725752
88Thyroid hormone synthesis_Homo sapiens_hsa049180.49999596
89Arginine biosynthesis_Homo sapiens_hsa002200.49948055
90Pancreatic secretion_Homo sapiens_hsa049720.49779462
91Fatty acid elongation_Homo sapiens_hsa000620.49634676
92Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49432449
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49111025
94Glutathione metabolism_Homo sapiens_hsa004800.48832124
95Calcium signaling pathway_Homo sapiens_hsa040200.48541869
96Endocytosis_Homo sapiens_hsa041440.46986471
97Prion diseases_Homo sapiens_hsa050200.46729998
98Bile secretion_Homo sapiens_hsa049760.45183357
99Inositol phosphate metabolism_Homo sapiens_hsa005620.44636756
100Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.44433872
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.44228098
102Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.43510572
103Prolactin signaling pathway_Homo sapiens_hsa049170.43267303
104Folate biosynthesis_Homo sapiens_hsa007900.43054554
105Fatty acid metabolism_Homo sapiens_hsa012120.41435981
106Endometrial cancer_Homo sapiens_hsa052130.40128434
107Alcoholism_Homo sapiens_hsa050340.38989842
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.38512196
109Ras signaling pathway_Homo sapiens_hsa040140.37780695
110Oocyte meiosis_Homo sapiens_hsa041140.36481407
111Fructose and mannose metabolism_Homo sapiens_hsa000510.36090928
112Histidine metabolism_Homo sapiens_hsa003400.36025016
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36004356
114Salmonella infection_Homo sapiens_hsa051320.35467735
115cGMP-PKG signaling pathway_Homo sapiens_hsa040220.35357551
116Dilated cardiomyopathy_Homo sapiens_hsa054140.34400459
117Rap1 signaling pathway_Homo sapiens_hsa040150.34093612
118Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34035521
119Cyanoamino acid metabolism_Homo sapiens_hsa004600.33886462
120Bladder cancer_Homo sapiens_hsa052190.33601965
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32994789
122Axon guidance_Homo sapiens_hsa043600.32858693
123Carbohydrate digestion and absorption_Homo sapiens_hsa049730.32288135
124Type II diabetes mellitus_Homo sapiens_hsa049300.32273063
125Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31959863
126Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.30710042
127ErbB signaling pathway_Homo sapiens_hsa040120.30572313
128Renin-angiotensin system_Homo sapiens_hsa046140.29552249
129Glycerophospholipid metabolism_Homo sapiens_hsa005640.29454696
130Choline metabolism in cancer_Homo sapiens_hsa052310.28814849

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