SND1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transcriptional co-activator that interacts with the acidic domain of Epstein-Barr virus nuclear antigen 2 (EBNA 2), a transcriptional activator that is required for B-lymphocyte transformation. Other transcription factors that interact with this protein are signal transducers and activators of transcription, STATs. This protein is also thought to be essential for normal cell growth. A similar protein in mammals and other organisms is a component of the RNA-induced silencing complex (RISC). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)6.40487299
2Golgi transport vesicle coating (GO:0048200)6.40487299
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.74108611
4folic acid-containing compound biosynthetic process (GO:0009396)4.67481999
5activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.36885532
6positive regulation of nuclease activity (GO:0032075)4.27270949
7protein retention in ER lumen (GO:0006621)4.25461510
8regulation of translational fidelity (GO:0006450)3.99645218
9mitotic chromosome condensation (GO:0007076)3.94338203
10regulation of nuclease activity (GO:0032069)3.90857311
11endoplasmic reticulum unfolded protein response (GO:0030968)3.87587789
124-hydroxyproline metabolic process (GO:0019471)3.82407406
13intestinal cholesterol absorption (GO:0030299)3.71274836
14cellular response to unfolded protein (GO:0034620)3.70029618
15formation of translation preinitiation complex (GO:0001731)3.69795534
16COPII vesicle coating (GO:0048208)3.64565873
17pore complex assembly (GO:0046931)3.62114483
18ER-nucleus signaling pathway (GO:0006984)3.61674505
19retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.57785741
20antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.52324330
21antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.52324330
22exocrine pancreas development (GO:0031017)3.51922876
23tetrahydrofolate metabolic process (GO:0046653)3.46213558
24cellular response to topologically incorrect protein (GO:0035967)3.44333374
25maternal placenta development (GO:0001893)3.44308021
26regulation of RNA export from nucleus (GO:0046831)3.36663881
27L-alpha-amino acid transmembrane transport (GO:1902475)3.31976518
28basement membrane organization (GO:0071711)3.25786778
29regulation of mammary gland epithelial cell proliferation (GO:0033599)3.19313182
30adherens junction assembly (GO:0034333)3.16361172
31positive regulation of histone deacetylation (GO:0031065)3.15689626
32protein maturation by protein folding (GO:0022417)3.15518271
33regulation of early endosome to late endosome transport (GO:2000641)3.15121204
34cell-substrate junction assembly (GO:0007044)3.13492607
35glucose 6-phosphate metabolic process (GO:0051156)3.13421848
36cell-substrate adherens junction assembly (GO:0007045)3.11773487
37focal adhesion assembly (GO:0048041)3.11773487
38protein localization to endosome (GO:0036010)3.11358192
39protein export from nucleus (GO:0006611)3.09594764
40response to endoplasmic reticulum stress (GO:0034976)3.06044367
41peptidyl-arginine omega-N-methylation (GO:0035247)3.05054425
42apoptotic cell clearance (GO:0043277)3.04893385
43hemidesmosome assembly (GO:0031581)3.04322896
44regulation of nucleobase-containing compound transport (GO:0032239)3.02496551
45regulation of cholesterol homeostasis (GO:2000188)3.00820373
46spliceosomal tri-snRNP complex assembly (GO:0000244)3.00528321
47pinocytosis (GO:0006907)2.98360451
48antigen processing and presentation of endogenous antigen (GO:0019883)2.97274066
49proline biosynthetic process (GO:0006561)2.96294881
50valine metabolic process (GO:0006573)2.94414280
51pentose-phosphate shunt (GO:0006098)2.91306673
52protein complex localization (GO:0031503)2.90628502
53glucose catabolic process (GO:0006007)2.90399733
54cellular protein complex localization (GO:0034629)2.89975743
55proline metabolic process (GO:0006560)2.88188565
56planar cell polarity pathway involved in neural tube closure (GO:0090179)2.87025292
57glycine metabolic process (GO:0006544)2.84784116
58regulation of fatty acid beta-oxidation (GO:0031998)2.84556969
59vesicle coating (GO:0006901)2.84147046
60regulation of glucose import in response to insulin stimulus (GO:2001273)2.81964846
61DNA duplex unwinding (GO:0032508)2.77966689
62negative regulation of cell size (GO:0045792)2.77380764
63one-carbon metabolic process (GO:0006730)2.77108346
64membrane disassembly (GO:0030397)2.76641285
65nuclear envelope disassembly (GO:0051081)2.76641285
66nuclear pore complex assembly (GO:0051292)2.76631469
67low-density lipoprotein particle clearance (GO:0034383)2.75590119
68mitotic sister chromatid segregation (GO:0000070)2.73038878
69antigen processing and presentation via MHC class Ib (GO:0002475)2.72457734
70skin morphogenesis (GO:0043589)2.70742987
71pteridine-containing compound biosynthetic process (GO:0042559)2.69706919
72serine family amino acid biosynthetic process (GO:0009070)2.69349793
73dosage compensation (GO:0007549)2.69100673
74negative regulation of fatty acid transport (GO:2000192)2.68263497
75response to unfolded protein (GO:0006986)2.67797859
76sulfur amino acid catabolic process (GO:0000098)2.67362389
77IMP biosynthetic process (GO:0006188)2.67351869
78DNA replication initiation (GO:0006270)2.67058896
79alpha-linolenic acid metabolic process (GO:0036109)2.66831057
80peptidyl-proline hydroxylation (GO:0019511)2.65902839
81protoporphyrinogen IX metabolic process (GO:0046501)2.65721750
82epithelial cell-cell adhesion (GO:0090136)2.64972334
83heterochromatin organization (GO:0070828)2.64437437
84DNA unwinding involved in DNA replication (GO:0006268)2.64056582
85epithelial cell differentiation involved in prostate gland development (GO:0060742)2.63662684
86regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.63359433
87embryonic process involved in female pregnancy (GO:0060136)2.62288283
88nuclear pore organization (GO:0006999)2.61976502
89ribosomal small subunit biogenesis (GO:0042274)2.61599842
90negative regulation of fibrinolysis (GO:0051918)2.61408573
91apoptotic process involved in morphogenesis (GO:0060561)2.61235853
92DNA strand elongation involved in DNA replication (GO:0006271)2.61144758
93DNA geometric change (GO:0032392)2.56714192
94DNA strand elongation (GO:0022616)2.56376121
95sister chromatid segregation (GO:0000819)2.54993174
96NADPH regeneration (GO:0006740)2.54822654
97chromosome condensation (GO:0030261)2.54534358
98L-serine metabolic process (GO:0006563)2.54275058
99response to topologically incorrect protein (GO:0035966)2.53975188
100cellular response to epidermal growth factor stimulus (GO:0071364)2.53907938
101protein localization to kinetochore (GO:0034501)2.53579100
102protein autoprocessing (GO:0016540)2.53510008
103protein hydroxylation (GO:0018126)2.51423638
104nucleosome disassembly (GO:0006337)2.50860879
105protein-DNA complex disassembly (GO:0032986)2.50860879
106peptidyl-lysine dimethylation (GO:0018027)2.50782929
107nucleobase-containing small molecule interconversion (GO:0015949)2.50518185
108positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.50431348
109folic acid-containing compound metabolic process (GO:0006760)2.50115809
110regulation of translational termination (GO:0006449)2.49562203
111insulin-like growth factor receptor signaling pathway (GO:0048009)2.49156334
112protein localization to chromosome, centromeric region (GO:0071459)2.48954192
113peptidyl-glutamic acid carboxylation (GO:0017187)2.48849375
114protein carboxylation (GO:0018214)2.48849375
115glucocorticoid receptor signaling pathway (GO:0042921)2.48714382
116cytoskeletal anchoring at plasma membrane (GO:0007016)2.47614195
117regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.47275630
118tricarboxylic acid metabolic process (GO:0072350)2.47105151
119regulation of histone H3-K27 methylation (GO:0061085)2.46806257
120nuclear envelope organization (GO:0006998)2.46748992
121regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.46503673
122UDP-N-acetylglucosamine metabolic process (GO:0006047)2.44073103
123positive regulation of fatty acid beta-oxidation (GO:0032000)2.43103591
124activation of Rac GTPase activity (GO:0032863)2.43062090
125positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.42076028
126DNA topological change (GO:0006265)2.41633580
127mannose metabolic process (GO:0006013)2.41175945
128desmosome organization (GO:0002934)2.40742441
129negative regulation of lipid transport (GO:0032369)2.40618756
130peptidyl-asparagine modification (GO:0018196)2.40574918
131histone arginine methylation (GO:0034969)2.40374482
132intestinal absorption (GO:0050892)2.40028943
133homocysteine metabolic process (GO:0050667)2.38887161
134sequestering of metal ion (GO:0051238)2.38749616
135protein N-linked glycosylation via asparagine (GO:0018279)2.38694064
136cell adhesion mediated by integrin (GO:0033627)2.38675951
137ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.38482326
138protoporphyrinogen IX biosynthetic process (GO:0006782)2.38391926
139cellular modified amino acid catabolic process (GO:0042219)2.37795396
140T cell apoptotic process (GO:0070231)2.37600435
141peptidyl-arginine methylation (GO:0018216)2.36796799
142establishment of apical/basal cell polarity (GO:0035089)2.35986363
143RNA stabilization (GO:0043489)2.35721833
144mRNA stabilization (GO:0048255)2.35721833
145cysteine metabolic process (GO:0006534)2.34438171
146regulation of hippo signaling (GO:0035330)2.34112262
147growth hormone receptor signaling pathway (GO:0060396)2.33131266
148urea metabolic process (GO:0019627)2.32054840
149urea cycle (GO:0000050)2.32054840
150organ regeneration (GO:0031100)2.30816692
151polarized epithelial cell differentiation (GO:0030859)2.28903340
152positive regulation of SMAD protein import into nucleus (GO:0060391)2.28378696
153lysine metabolic process (GO:0006553)2.26742839
154lysine catabolic process (GO:0006554)2.26742839
155IMP metabolic process (GO:0046040)2.25790721
156positive regulation of triglyceride biosynthetic process (GO:0010867)2.24216360
157mitotic nuclear envelope disassembly (GO:0007077)2.23661169
158pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.22867928
159UMP biosynthetic process (GO:0006222)2.22867928
160pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.22867928
161UMP metabolic process (GO:0046049)2.22867928

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.81206764
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.64704785
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.64180484
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.59364342
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.14290980
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.80452074
7MYC_22102868_ChIP-Seq_BL_Human2.80320575
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.70951412
9PPARA_22158963_ChIP-Seq_LIVER_Mouse2.53629755
10RXR_22158963_ChIP-Seq_LIVER_Mouse2.48194132
11STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.40175939
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.40061888
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.20852519
14CLOCK_20551151_ChIP-Seq_293T_Human2.20575885
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.20309110
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.00879593
17LXR_22158963_ChIP-Seq_LIVER_Mouse1.98016466
18VDR_21846776_ChIP-Seq_THP-1_Human1.94678380
19TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.85733634
20MYC_18358816_ChIP-ChIP_MESCs_Mouse1.82366377
21MYC_18555785_ChIP-Seq_MESCs_Mouse1.80738083
22RARG_19884340_ChIP-ChIP_MEFs_Mouse1.59908203
23ELK3_25401928_ChIP-Seq_HUVEC_Human1.58831653
24TCF7_22412390_ChIP-Seq_EML_Mouse1.57433430
25KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.56138369
26GATA1_22025678_ChIP-Seq_K562_Human1.51846683
27IRF8_22096565_ChIP-ChIP_GC-B_Human1.49668367
28AR_21909140_ChIP-Seq_LNCAP_Human1.48771172
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.48750269
30NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.44620594
31KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.43210601
32KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.43034282
33HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.40130664
34STAT3_1855785_ChIP-Seq_MESCs_Mouse1.39097926
35* ATF3_27146783_Chip-Seq_COLON_Human1.37545744
36BRD4_27068464_Chip-Seq_AML-cells_Mouse1.37208658
37CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.36281127
38* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.35992495
39TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35310340
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.35136349
41ZNF263_19887448_ChIP-Seq_K562_Human1.35104642
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.34523589
43* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.31448904
44MYC_19079543_ChIP-ChIP_MESCs_Mouse1.31141190
45ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.30415278
46RACK7_27058665_Chip-Seq_MCF-7_Human1.30283578
47E2F4_17652178_ChIP-ChIP_JURKAT_Human1.29868600
48POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.29463977
49NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.28580276
50TFEB_21752829_ChIP-Seq_HELA_Human1.28433623
51UTX_26944678_Chip-Seq_JUKART_Human1.28201480
52E2F1_21310950_ChIP-Seq_MCF-7_Human1.26523395
53ESR1_15608294_ChIP-ChIP_MCF-7_Human1.26003130
54MAF_26560356_Chip-Seq_TH1_Human1.25672836
55KDM2B_26808549_Chip-Seq_DND41_Human1.25045183
56HIF1A_21447827_ChIP-Seq_MCF-7_Human1.24894557
57CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.24376561
58GATA6_25053715_ChIP-Seq_YYC3_Human1.24204623
59THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.23018895
60THAP11_20581084_ChIP-Seq_MESCs_Mouse1.21368391
61SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.21102663
62MYB_21317192_ChIP-Seq_ERMYB_Mouse1.21027696
63KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.20436107
64* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.20316644
65PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.20159197
66LXR_22292898_ChIP-Seq_THP-1_Human1.19395704
67SOX2_27498859_Chip-Seq_STOMACH_Mouse1.17678671
68CHD1_26751641_Chip-Seq_LNCaP_Human1.17246139
69* NCOR1_26117541_ChIP-Seq_K562_Human1.16532271
70NELFA_20434984_ChIP-Seq_ESCs_Mouse1.16511047
71TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.16245310
72ZFP281_18757296_ChIP-ChIP_E14_Mouse1.16213833
73WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.16052202
74TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.15666771
75ZFX_18555785_ChIP-Seq_MESCs_Mouse1.14604157
76UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.13411051
77P300_27058665_Chip-Seq_ZR-75-30cells_Human1.13161363
78SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.13063921
79TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12775682
80ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.12153833
81TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.10900437
82E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.10499396
83EGR1_23403033_ChIP-Seq_LIVER_Mouse1.10457172
84DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09980166
85VDR_24763502_ChIP-Seq_THP-1_Human1.09702723
86DCP1A_22483619_ChIP-Seq_HELA_Human1.09115725
87KDM5A_27292631_Chip-Seq_BREAST_Human1.08404402
88FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.06958752
89KDM2B_26808549_Chip-Seq_SUP-B15_Human1.05687922
90TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05234923
91CIITA_25753668_ChIP-Seq_RAJI_Human1.04860893
92KDM2B_26808549_Chip-Seq_K562_Human1.04842846
93UBF1/2_26484160_Chip-Seq_HMECs_Human1.04241721
94* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.04233929
95NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.04082960
96NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.03673400
97* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.03525328
98* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.02345711
99EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02343643
100TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.02116604
101* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.01938805
102* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.01929324
103FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.01863239
104DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.01289503
105HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.01245211
106SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.00895651
107NANOG_21062744_ChIP-ChIP_HESCs_Human1.00237857
108ERG_20887958_ChIP-Seq_HPC-7_Mouse1.00099189
109CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.00010199
110XRN2_22483619_ChIP-Seq_HELA_Human0.99551560
111TP53_22127205_ChIP-Seq_IMR90_Human0.99076263
112ESR1_21235772_ChIP-Seq_MCF-7_Human0.98917996
113GATA1_22383799_ChIP-Seq_G1ME_Mouse0.97960060
114NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.97654377
115CTCF_27219007_Chip-Seq_ERYTHROID_Human0.97571876
116* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.97180839
117SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.96922464
118STAT6_21828071_ChIP-Seq_BEAS2B_Human0.96855884
119JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.96027955
120RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.95786354
121STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.95149078
122CREB1_15753290_ChIP-ChIP_HEK293T_Human0.95127260
123CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.94876123
124* MYB_26560356_Chip-Seq_TH1_Human0.94775998
125* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.94518012
126MYB_26560356_Chip-Seq_TH2_Human0.94344936
127ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.94338251
128PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.92221156
129SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.91762808
130* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.91581192
131ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.91514241
132KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.89706316
133ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.89593058
134* RUNX1_22412390_ChIP-Seq_EML_Mouse0.89147976

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.85193010
2MP0010352_gastrointestinal_tract_polyps2.75214183
3MP0002877_abnormal_melanocyte_morpholog2.74601153
4MP0008438_abnormal_cutaneous_collagen2.68838737
5MP0005451_abnormal_body_composition2.66898046
6MP0002139_abnormal_hepatobiliary_system2.55795986
7MP0005083_abnormal_biliary_tract2.51376767
8MP0003300_gastrointestinal_ulcer2.48900833
9MP0005365_abnormal_bile_salt2.38954563
10MP0005076_abnormal_cell_differentiation2.15722579
11MP0003566_abnormal_cell_adhesion2.13345347
12MP0010234_abnormal_vibrissa_follicle2.03227650
13MP0006054_spinal_hemorrhage1.97953029
14MP0005220_abnormal_exocrine_pancreas1.95523606
15MP0004264_abnormal_extraembryonic_tissu1.92431634
16MP0005085_abnormal_gallbladder_physiolo1.91469617
17MP0005360_urolithiasis1.91121538
18MP0009840_abnormal_foam_cell1.86189891
19MP0001666_abnormal_nutrient_absorption1.82489936
20MP0003252_abnormal_bile_duct1.80006957
21MP0008932_abnormal_embryonic_tissue1.67843055
22MP0010094_abnormal_chromosome_stability1.64149441
23MP0004858_abnormal_nervous_system1.60529591
24MP0010307_abnormal_tumor_latency1.54121559
25MP0005023_abnormal_wound_healing1.50733146
26MP0003283_abnormal_digestive_organ1.49549389
27MP0003941_abnormal_skin_development1.46967299
28MP0005623_abnormal_meninges_morphology1.46843502
29MP0010030_abnormal_orbit_morphology1.42644083
30MP0001661_extended_life_span1.41809126
31MP0008057_abnormal_DNA_replication1.30898889
32MP0008260_abnormal_autophagy1.30610661
33MP0005409_darkened_coat_color1.27528052
34MP0005408_hypopigmentation1.24711482
35MP0002089_abnormal_postnatal_growth/wei1.24418981
36MP0010329_abnormal_lipoprotein_level1.23930133
37MP0005058_abnormal_lysosome_morphology1.23195738
38MP0003806_abnormal_nucleotide_metabolis1.23013887
39MP0001849_ear_inflammation1.22507994
40MP0002166_altered_tumor_susceptibility1.21256581
41MP0005501_abnormal_skin_physiology1.21231471
42MP0000371_diluted_coat_color1.19591828
43MP0000609_abnormal_liver_physiology1.18500253
44MP0005275_abnormal_skin_tensile1.18010648
45MP0005621_abnormal_cell_physiology1.17805246
46MP0004197_abnormal_fetal_growth/weight/1.15100605
47MP0002796_impaired_skin_barrier1.15065029
48MP0003868_abnormal_feces_composition1.12787567
49MP0005257_abnormal_intraocular_pressure1.12298847
50MP0004185_abnormal_adipocyte_glucose1.11918809
51MP0001944_abnormal_pancreas_morphology1.11293513
52MP0004272_abnormal_basement_membrane1.07803655
53MP0001730_embryonic_growth_arrest1.05790498
54MP0002086_abnormal_extraembryonic_tissu1.04816392
55MP0003693_abnormal_embryo_hatching1.02793254
56MP0004947_skin_inflammation1.02385842
57MP0000598_abnormal_liver_morphology1.02216569
58MP0004957_abnormal_blastocyst_morpholog1.01441156
59MP0002396_abnormal_hematopoietic_system1.01291522
60MP0004808_abnormal_hematopoietic_stem1.01232791
61MP0002060_abnormal_skin_morphology1.00930238
62MP0001915_intracranial_hemorrhage1.00825574
63MP0003385_abnormal_body_wall1.00802335
64MP0000537_abnormal_urethra_morphology1.00313848
65MP0003172_abnormal_lysosome_physiology0.99675248
66MP0009278_abnormal_bone_marrow0.99184056
67MP0003191_abnormal_cellular_cholesterol0.99045872
68MP0000678_abnormal_parathyroid_gland0.98465487
69MP0000733_abnormal_muscle_development0.98375563
70MP0003303_peritoneal_inflammation0.98252269
71MP0003091_abnormal_cell_migration0.95907642
72MP0002693_abnormal_pancreas_physiology0.95140864
73MP0002928_abnormal_bile_duct0.94912799
74MP0005384_cellular_phenotype0.94449788
75MP0002088_abnormal_embryonic_growth/wei0.94184285
76MP0000858_altered_metastatic_potential0.93954792
77MP0003453_abnormal_keratinocyte_physiol0.93674454
78MP0003984_embryonic_growth_retardation0.93522904
79MP0000003_abnormal_adipose_tissue0.92102897
80MP0000350_abnormal_cell_proliferation0.91638154
81MP0002896_abnormal_bone_mineralization0.91560092
82MP0009053_abnormal_anal_canal0.90788171
83MP0000490_abnormal_crypts_of0.90451378
84MP0005380_embryogenesis_phenotype0.89802009
85MP0001672_abnormal_embryogenesis/_devel0.89802009
86MP0003279_aneurysm0.89317685
87MP0002138_abnormal_hepatobiliary_system0.88817520
88MP0000313_abnormal_cell_death0.88164053
89MP0008961_abnormal_basal_metabolism0.87749038
90MP0003123_paternal_imprinting0.87136739
91MP0001216_abnormal_epidermal_layer0.86777504
92MP0005503_abnormal_tendon_morphology0.86575494
93MP0000569_abnormal_digit_pigmentation0.85210241
94MP0003077_abnormal_cell_cycle0.83471459
95MP0002080_prenatal_lethality0.82942290
96MP0009931_abnormal_skin_appearance0.82589659
97MP0003111_abnormal_nucleus_morphology0.82100581
98MP0000762_abnormal_tongue_morphology0.82026339
99MP0010630_abnormal_cardiac_muscle0.81144441
100MP0002009_preneoplasia0.80322583
101MP0009672_abnormal_birth_weight0.80151074
102MP0009384_cardiac_valve_regurgitation0.80057341
103MP0003942_abnormal_urinary_system0.79873225
104MP0009643_abnormal_urine_homeostasis0.79566634
105MP0002084_abnormal_developmental_patter0.79344868
106MP0000467_abnormal_esophagus_morphology0.79249410
107MP0001697_abnormal_embryo_size0.79200433
108MP0002697_abnormal_eye_size0.79130689
109MP0003045_fibrosis0.79019371
110MP0008007_abnormal_cellular_replicative0.78532283
111MP0003436_decreased_susceptibility_to0.77902821
112MP0005171_absent_coat_pigmentation0.77654950
113MP0005375_adipose_tissue_phenotype0.77641267
114MP0001243_abnormal_dermal_layer0.77437899
115MP0000579_abnormal_nail_morphology0.77098629
116MP0005319_abnormal_enzyme/_coenzyme0.76831496
117MP0001881_abnormal_mammary_gland0.75733351
118MP0000685_abnormal_immune_system0.75016399
119MP0001873_stomach_inflammation0.74183163
120MP0000627_abnormal_mammary_gland0.73983344
121MP0000767_abnormal_smooth_muscle0.73641462
122MP0005464_abnormal_platelet_physiology0.73562847
123MP0000377_abnormal_hair_follicle0.72033186
124MP0005508_abnormal_skeleton_morphology0.71604016
125MP0000358_abnormal_cell_content/0.71458864
126MP0005666_abnormal_adipose_tissue0.71304471
127MP0003115_abnormal_respiratory_system0.70821016
128MP0001958_emphysema0.70643735
129MP0001348_abnormal_lacrimal_gland0.69586728
130MP0000428_abnormal_craniofacial_morphol0.69058678
131MP0003959_abnormal_lean_body0.68434882
132MP0000477_abnormal_intestine_morphology0.67976086
133MP0002085_abnormal_embryonic_tissue0.66897569
134MP0004233_abnormal_muscle_weight0.66522345
135MP0002118_abnormal_lipid_homeostasis0.66243133
136MP0002006_tumorigenesis0.66110996

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)3.37596909
2Cerebral aneurysm (HP:0004944)3.33587344
3Vertebral compression fractures (HP:0002953)3.29377800
4Cholecystitis (HP:0001082)3.03714935
5Abnormal gallbladder physiology (HP:0012438)3.03714935
6Deep venous thrombosis (HP:0002625)2.97217774
7Hypoglycemic coma (HP:0001325)2.92166484
8Insomnia (HP:0100785)2.83119653
9Ankyloglossia (HP:0010296)2.82501993
10Abnormality of the intrinsic pathway (HP:0010989)2.70676712
11Cervical subluxation (HP:0003308)2.67984414
12Premature rupture of membranes (HP:0001788)2.66371534
13Abnormality of monocarboxylic acid metabolism (HP:0010996)2.65214041
14Abnormality of oral frenula (HP:0000190)2.58635799
15Abnormality of the common coagulation pathway (HP:0010990)2.57732217
16Abnormality of the pancreatic islet cells (HP:0006476)2.57571463
17Abnormality of endocrine pancreas physiology (HP:0012093)2.57571463
18Aneurysm (HP:0002617)2.56170762
19Intrahepatic cholestasis (HP:0001406)2.54747783
20Disproportionate tall stature (HP:0001519)2.54359607
21Hypoglycemic seizures (HP:0002173)2.53500389
22Achilles tendon contracture (HP:0001771)2.53235786
23Fragile skin (HP:0001030)2.51300457
24Hyperinsulinemic hypoglycemia (HP:0000825)2.46323149
25Ankle contracture (HP:0006466)2.44936211
26Biconcave vertebral bodies (HP:0004586)2.43484678
27Shallow orbits (HP:0000586)2.42375704
28Subacute progressive viral hepatitis (HP:0006572)2.39862697
29Xanthomatosis (HP:0000991)2.35129663
30Spastic diplegia (HP:0001264)2.34450135
31Renal duplication (HP:0000075)2.31979104
32Hand muscle atrophy (HP:0009130)2.31817283
33Abnormality of the Achilles tendon (HP:0005109)2.31264924
34Aortic aneurysm (HP:0004942)2.27908534
35Asymmetry of the thorax (HP:0001555)2.27090265
36Dysmetric saccades (HP:0000641)2.26742185
37Trismus (HP:0000211)2.25454507
38Abnormality of dentin (HP:0010299)2.23978412
39Myocardial infarction (HP:0001658)2.22482673
40Late onset (HP:0003584)2.19037266
41Ulnar bowing (HP:0003031)2.18660254
42Mitral valve prolapse (HP:0001634)2.18124796
43Upper limb amyotrophy (HP:0009129)2.16831495
44Distal upper limb amyotrophy (HP:0007149)2.16831495
45Peritonitis (HP:0002586)2.15092494
46Increased density of long bones (HP:0006392)2.14839491
47Distal lower limb amyotrophy (HP:0008944)2.14615357
48Pancreatic islet-cell hyperplasia (HP:0004510)2.14142749
49Mucopolysacchariduria (HP:0008155)2.13864608
50Urinary glycosaminoglycan excretion (HP:0003541)2.13864608
51Spinal rigidity (HP:0003306)2.13104117
52Reticulocytosis (HP:0001923)2.13035906
53Back pain (HP:0003418)2.12050056
54Overriding aorta (HP:0002623)2.10790639
55Enlarged penis (HP:0000040)2.10455438
56Elbow flexion contracture (HP:0002987)2.09565019
57Natal tooth (HP:0000695)2.08794656
58Increased mean platelet volume (HP:0011877)2.08374241
59Long palpebral fissure (HP:0000637)2.07793602
60Advanced eruption of teeth (HP:0006288)2.05960475
61Centrally nucleated skeletal muscle fibers (HP:0003687)2.05790332
62Premature skin wrinkling (HP:0100678)2.05489030
63Long toe (HP:0010511)2.04791458
64Breech presentation (HP:0001623)2.04230002
65Hyperacusis (HP:0010780)2.03497100
66Short nail (HP:0001799)2.02325384
67Flat cornea (HP:0007720)2.01159926
68Orthostatic hypotension (HP:0001278)2.00276963
69Broad face (HP:0000283)1.98970165
70Elfin facies (HP:0004428)1.96604545
71Ketoacidosis (HP:0001993)1.96313696
72Abnormal platelet volume (HP:0011876)1.95312964
73Patellar dislocation (HP:0002999)1.93924601
74Dilatation of the ascending aorta (HP:0005111)1.93648177
75Hyperglycemia (HP:0003074)1.93493333
76Thin bony cortex (HP:0002753)1.92661303
77Thrombocytosis (HP:0001894)1.92642799
78Radial bowing (HP:0002986)1.91229465
79Lymphangioma (HP:0100764)1.91194340
80Abnormality of polysaccharide metabolism (HP:0011012)1.90996464
81Abnormality of glycosaminoglycan metabolism (HP:0004371)1.90996464
82Abnormality of mucopolysaccharide metabolism (HP:0011020)1.90996464
83Nonimmune hydrops fetalis (HP:0001790)1.90835971
84Osteolytic defects of the phalanges of the hand (HP:0009771)1.90712408
85Osteolytic defects of the hand bones (HP:0009699)1.90712408
86Bowel diverticulosis (HP:0005222)1.90642492
87Abnormality of aromatic amino acid family metabolism (HP:0004338)1.90245887
88Increased nuchal translucency (HP:0010880)1.88860465
89Severe short stature (HP:0003510)1.88795060
90Aortic dissection (HP:0002647)1.88440841
91Blue sclerae (HP:0000592)1.87987609
92Bladder diverticulum (HP:0000015)1.87185959
93Pseudobulbar signs (HP:0002200)1.87090866
94Macroorchidism (HP:0000053)1.85349827
95Esophageal varix (HP:0002040)1.85079416
96Selective tooth agenesis (HP:0001592)1.84721839
97Relative macrocephaly (HP:0004482)1.84361105
98Hepatocellular carcinoma (HP:0001402)1.83752669
99Increased connective tissue (HP:0009025)1.80890618
100Abnormal delivery (HP:0001787)1.80276985
101Atrophic scars (HP:0001075)1.79520081
102Turricephaly (HP:0000262)1.79068879
103Overlapping toe (HP:0001845)1.78604390
104Hypobetalipoproteinemia (HP:0003563)1.77774358
105Insulin resistance (HP:0000855)1.77145147
106Complement deficiency (HP:0004431)1.76723603
107Abnormality of sulfur amino acid metabolism (HP:0004339)1.76687634
108Ketosis (HP:0001946)1.76060054
109Hematochezia (HP:0002573)1.75739406
110Abnormality of the calcaneus (HP:0008364)1.74381018
111Skin nodule (HP:0200036)1.74366393
112Arterial tortuosity (HP:0005116)1.71762397
113Micronodular cirrhosis (HP:0001413)1.71731028
114Rectal prolapse (HP:0002035)1.71704866
115Bowing of the arm (HP:0006488)1.71243204
116Bowed forearm bones (HP:0003956)1.71243204
117Abnormality of reticulocytes (HP:0004312)1.70588268
118Abnormality of complement system (HP:0005339)1.69357739
119Genu recurvatum (HP:0002816)1.68527281
120Abnormality of the peritoneum (HP:0002585)1.67989915
121Abnormality of the distal phalanges of the toes (HP:0010182)1.67898455
122Fat malabsorption (HP:0002630)1.67776344
123Abnormality of the distal phalanx of the thumb (HP:0009617)1.67320191
124Dysostosis multiplex (HP:0000943)1.67279673
125Symptomatic seizures (HP:0011145)1.67092090
126Missing ribs (HP:0000921)1.66557815
127Ependymoma (HP:0002888)1.66301630
128Joint laxity (HP:0001388)1.66130930
129Vascular tortuosity (HP:0004948)1.65669912
130Ectopia lentis (HP:0001083)1.65474786
131Abnormal ossification of hand bones (HP:0005921)1.65124886
132Thoracolumbar scoliosis (HP:0002944)1.65076343
133Flat acetabular roof (HP:0003180)1.64456579
134Abnormality of carpal bone ossification (HP:0006257)1.63658883
135Hyperextensible skin (HP:0000974)1.63474374
136Abnormality of glycolysis (HP:0004366)1.63212543
137Delayed cranial suture closure (HP:0000270)1.62360524
138Upper motor neuron abnormality (HP:0002127)1.62246037
139Abnormality of the thoracic spine (HP:0100711)1.62044630
140Syringomyelia (HP:0003396)1.62030388
141Spinal cord lesions (HP:0100561)1.62030388
142Periodontitis (HP:0000704)1.61086332
143Soft skin (HP:0000977)1.60458695
144Wormian bones (HP:0002645)1.60137886
145Exostoses (HP:0100777)1.59932171
146Arnold-Chiari malformation (HP:0002308)1.59913300
147Abnormal cartilage morphology (HP:0002763)1.59751289
148Cutaneous melanoma (HP:0012056)1.59358762
149Deviation of the thumb (HP:0009603)1.58395953
150Pointed chin (HP:0000307)1.57168390
151Mildly elevated creatine phosphokinase (HP:0008180)1.55173468
152Mitral regurgitation (HP:0001653)1.54683469
153Progressive muscle weakness (HP:0003323)1.54463881
154Persistence of primary teeth (HP:0006335)1.54390750
155Hallux valgus (HP:0001822)1.53733247
156Epidermoid cyst (HP:0200040)1.53693692
157Abnormality of the acetabulum (HP:0003170)1.53626136
158Microvesicular hepatic steatosis (HP:0001414)1.53541208
159Increased variability in muscle fiber diameter (HP:0003557)1.53322332
160Renovascular hypertension (HP:0100817)1.52819225
161Deep philtrum (HP:0002002)1.51827741
162Long eyelashes (HP:0000527)1.50175938
163Sparse lateral eyebrow (HP:0005338)1.49920509
164Abnormality of the tricuspid valve (HP:0001702)1.49497811

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.28015815
2PKN24.09523553
3EEF2K4.00999474
4SMG13.85716376
5ERN13.43167764
6MAP3K102.60877936
7PRPF4B2.53302845
8SIK12.53180703
9IRAK32.46493143
10FLT32.35166405
11TAOK32.32649866
12PTK62.28543706
13SCYL22.27592017
14CDK122.22642158
15NME22.11469695
16PASK2.10326975
17TTN2.00990234
18PDGFRA1.93176987
19LATS11.86025786
20FGFR41.60071698
21LRRK21.58705644
22LATS21.54120794
23EPHA21.54119274
24RPS6KB21.53265041
25RIPK11.45525251
26BCKDK1.44661362
27KSR21.39803043
28STK101.34001663
29BMX1.33351754
30FRK1.31193058
31MTOR1.26248711
32NTRK11.25766197
33PAK41.22912925
34MET1.16959003
35PAK21.16707894
36JAK31.16440304
37PTK21.15306933
38LMTK21.14343842
39CAMK1D1.04696083
40NEK21.04526649
41MAP4K11.03906392
42CDK61.02737786
43MAP3K81.02560679
44ARAF0.97810448
45BUB10.97690670
46CDK40.94794737
47EIF2AK10.94394158
48EPHB10.93855255
49DDR20.92927885
50MST1R0.91139879
51ALK0.90827223
52BRAF0.89715593
53TYK20.88929606
54INSRR0.88886869
55TAOK20.88116788
56RPS6KA40.85324211
57MAP2K30.84940287
58CDC70.84011044
59PDGFRB0.83490233
60ZAP700.81648844
61JAK10.81276831
62EPHA30.79427581
63MAPKAPK30.77431892
64PIM20.77132587
65CLK10.75748414
66RAF10.75474017
67STK30.75272497
68FGFR30.74801264
69MAP3K130.73735129
70TGFBR10.73723501
71ICK0.72930464
72HIPK20.72182802
73TRPM70.70250367
74VRK20.70197729
75CSF1R0.68904935
76CHUK0.68686729
77NEK90.68273894
78CHEK20.66512983
79PBK0.65680202
80RET0.65516092
81BTK0.63475520
82PIM10.63297870
83JAK20.62980024
84MAP3K30.62223348
85TESK20.62138573
86CCNB10.61609888
87TBK10.61371076
88EIF2AK30.61033118
89GRK60.60341848
90MAP2K20.60190090
91TSSK60.58739602
92CDK70.57649780
93FGFR10.56715147
94CAMK1G0.56591252
95DYRK1B0.54893169
96MAPK110.54584486
97SRPK10.53245508
98TAF10.52306213
99AURKA0.51978979
100ERBB40.51815853
101PIK3CG0.51353350
102FER0.51007325
103MOS0.49787858
104NEK10.49594254
105CSK0.49353500
106MAP3K20.48769194
107TGFBR20.48690559
108BRSK20.48110825
109MAP3K90.48064023
110PDPK10.47384983
111AURKB0.47288453
112TESK10.47027503
113MAP3K10.46882468
114CDK90.45743293
115ILK0.44929835
116KDR0.44554830
117CDC42BPA0.44324264
118STK40.44260616
119TTK0.43795638
120ATR0.43511956
121RPS6KA20.42064856
122ITK0.40803706
123MARK20.38594172
124CDK20.38446527
125PAK10.38241749
126GSK3A0.38192792
127AKT20.37734596
128CDK80.37404787
129BRD40.36083833
130PRKD30.35793950
131PRKD20.35556261
132CHEK10.35496675
133MAPK150.35176942
134RPS6KL10.34231946
135RPS6KC10.34231946
136CDK10.33260514
137MELK0.33236993
138KIT0.33220220
139RPS6KA60.32931083
140EGFR0.31948060
141RPS6KA10.31627768
142MAP3K70.29709071

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.01597712
2One carbon pool by folate_Homo sapiens_hsa006702.85560173
3Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.48414673
4Selenocompound metabolism_Homo sapiens_hsa004502.44178958
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.18247929
6Nitrogen metabolism_Homo sapiens_hsa009102.15684536
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.93222691
8Lysine degradation_Homo sapiens_hsa003101.73216815
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.67687546
10Primary bile acid biosynthesis_Homo sapiens_hsa001201.65136430
11Fat digestion and absorption_Homo sapiens_hsa049751.65110448
12Arginine biosynthesis_Homo sapiens_hsa002201.57479111
13Tryptophan metabolism_Homo sapiens_hsa003801.53454751
14Biosynthesis of amino acids_Homo sapiens_hsa012301.40602308
15N-Glycan biosynthesis_Homo sapiens_hsa005101.39447917
16Fatty acid degradation_Homo sapiens_hsa000711.36337114
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.35611722
18Chronic myeloid leukemia_Homo sapiens_hsa052201.31919156
19Complement and coagulation cascades_Homo sapiens_hsa046101.27380190
20Caffeine metabolism_Homo sapiens_hsa002321.26523275
21Small cell lung cancer_Homo sapiens_hsa052221.24608403
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.22589143
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.22150373
24Bladder cancer_Homo sapiens_hsa052191.19607669
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.19542055
26Base excision repair_Homo sapiens_hsa034101.18652768
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.16976368
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.14776386
29Central carbon metabolism in cancer_Homo sapiens_hsa052301.10449667
30Glycosaminoglycan degradation_Homo sapiens_hsa005311.07843108
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.07014369
32Insulin resistance_Homo sapiens_hsa049311.05272095
33Antigen processing and presentation_Homo sapiens_hsa046121.05038444
34Mismatch repair_Homo sapiens_hsa034301.03090744
35Galactose metabolism_Homo sapiens_hsa000521.01673537
36Protein digestion and absorption_Homo sapiens_hsa049741.01369733
37Thyroid hormone signaling pathway_Homo sapiens_hsa049191.01251467
38mRNA surveillance pathway_Homo sapiens_hsa030151.00237851
39Spliceosome_Homo sapiens_hsa030401.00004755
40Vibrio cholerae infection_Homo sapiens_hsa051100.98007329
41Adherens junction_Homo sapiens_hsa045200.97085718
42Starch and sucrose metabolism_Homo sapiens_hsa005000.96576952
43Renal cell carcinoma_Homo sapiens_hsa052110.96203686
44Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.96117527
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.96088543
46mTOR signaling pathway_Homo sapiens_hsa041500.94716593
47Carbon metabolism_Homo sapiens_hsa012000.94584778
48Glioma_Homo sapiens_hsa052140.94282497
49MicroRNAs in cancer_Homo sapiens_hsa052060.93475816
50Pentose and glucuronate interconversions_Homo sapiens_hsa000400.91625864
51Focal adhesion_Homo sapiens_hsa045100.91178660
52ErbB signaling pathway_Homo sapiens_hsa040120.91037817
53* Viral carcinogenesis_Homo sapiens_hsa052030.90698904
54Colorectal cancer_Homo sapiens_hsa052100.89267422
55Proteoglycans in cancer_Homo sapiens_hsa052050.88810879
56HIF-1 signaling pathway_Homo sapiens_hsa040660.86037306
57Notch signaling pathway_Homo sapiens_hsa043300.85828790
58VEGF signaling pathway_Homo sapiens_hsa043700.85166956
59Fatty acid metabolism_Homo sapiens_hsa012120.84731991
60Folate biosynthesis_Homo sapiens_hsa007900.83770688
61Vitamin B6 metabolism_Homo sapiens_hsa007500.83734277
62Pyruvate metabolism_Homo sapiens_hsa006200.83164897
63Nucleotide excision repair_Homo sapiens_hsa034200.82349119
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81777920
65Legionellosis_Homo sapiens_hsa051340.81241349
66DNA replication_Homo sapiens_hsa030300.80888265
67Systemic lupus erythematosus_Homo sapiens_hsa053220.80332000
68Acute myeloid leukemia_Homo sapiens_hsa052210.79242586
69ABC transporters_Homo sapiens_hsa020100.78603087
70Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.77698668
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77048339
72Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.76878833
73ECM-receptor interaction_Homo sapiens_hsa045120.75368864
74Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.74886733
75Staphylococcus aureus infection_Homo sapiens_hsa051500.74139610
76Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74088790
77Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.71258760
78Thyroid cancer_Homo sapiens_hsa052160.70974272
79Toxoplasmosis_Homo sapiens_hsa051450.70201383
80Sulfur metabolism_Homo sapiens_hsa009200.69691075
81Pancreatic cancer_Homo sapiens_hsa052120.69521512
82Pentose phosphate pathway_Homo sapiens_hsa000300.69520234
83Apoptosis_Homo sapiens_hsa042100.69221170
84PPAR signaling pathway_Homo sapiens_hsa033200.68810446
85Other glycan degradation_Homo sapiens_hsa005110.67611299
86Amoebiasis_Homo sapiens_hsa051460.67498458
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67321114
88Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.66762386
89Cysteine and methionine metabolism_Homo sapiens_hsa002700.66147374
90Non-small cell lung cancer_Homo sapiens_hsa052230.66018103
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.64994807
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.64678567
93Shigellosis_Homo sapiens_hsa051310.64107342
94p53 signaling pathway_Homo sapiens_hsa041150.63338215
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62612452
96Renin-angiotensin system_Homo sapiens_hsa046140.62084033
97Protein export_Homo sapiens_hsa030600.61824756
98Steroid biosynthesis_Homo sapiens_hsa001000.60481582
99Endometrial cancer_Homo sapiens_hsa052130.59442431
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.59110192
101Prolactin signaling pathway_Homo sapiens_hsa049170.58446997
102Non-homologous end-joining_Homo sapiens_hsa034500.57804195
103AMPK signaling pathway_Homo sapiens_hsa041520.57720617
104Lysosome_Homo sapiens_hsa041420.57479033
105Prostate cancer_Homo sapiens_hsa052150.57403374
106HTLV-I infection_Homo sapiens_hsa051660.56666954
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.56389464
108Sulfur relay system_Homo sapiens_hsa041220.55599141
109B cell receptor signaling pathway_Homo sapiens_hsa046620.55343716
110AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.54979947
111Viral myocarditis_Homo sapiens_hsa054160.54859956
112RNA transport_Homo sapiens_hsa030130.54610493
113Hepatitis B_Homo sapiens_hsa051610.52959369
114Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51806852
115Pathways in cancer_Homo sapiens_hsa052000.51522634
116Bile secretion_Homo sapiens_hsa049760.50678446
117Cell cycle_Homo sapiens_hsa041100.50455332
118Phenylalanine metabolism_Homo sapiens_hsa003600.49941717
119Ribosome_Homo sapiens_hsa030100.49858879
120Type II diabetes mellitus_Homo sapiens_hsa049300.49502673
121Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48083807
122Insulin signaling pathway_Homo sapiens_hsa049100.48082876
123Pancreatic secretion_Homo sapiens_hsa049720.45626595
124Melanoma_Homo sapiens_hsa052180.45574040
125Arginine and proline metabolism_Homo sapiens_hsa003300.45250883
126Pyrimidine metabolism_Homo sapiens_hsa002400.45248293
127Fructose and mannose metabolism_Homo sapiens_hsa000510.44600702
128PI3K-Akt signaling pathway_Homo sapiens_hsa041510.44564266
129Thyroid hormone synthesis_Homo sapiens_hsa049180.44428860
130Tyrosine metabolism_Homo sapiens_hsa003500.44212910
131Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43574979
132Leishmaniasis_Homo sapiens_hsa051400.43338415
133Prion diseases_Homo sapiens_hsa050200.42994954
134Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41493425
135Hepatitis C_Homo sapiens_hsa051600.41120356
136Alcoholism_Homo sapiens_hsa050340.39983992
137Inositol phosphate metabolism_Homo sapiens_hsa005620.38171837

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