SNIP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that contains a coiled-coil motif and C-terminal forkhead-associated (FHA) domain. The encoded protein functions as a transcriptional coactivator that increases c-Myc activity and inhibits transforming growth factor beta (TGF-beta) and nuclear factor kappa-B (NF-kB) signaling. The encoded protein also regulates the stability of cyclin D1 mRNA, and may play a role in cell proliferation and cancer progression. Mutations in this gene are a cause of psychomotor retardation, epilepsy, and craniofacial dysmorphism (PMRED). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein K11-linked deubiquitination (GO:0035871)5.29092098
2DNA deamination (GO:0045006)4.92045247
3piRNA metabolic process (GO:0034587)4.82497237
4DNA strand elongation involved in DNA replication (GO:0006271)4.48512824
5ribosomal small subunit assembly (GO:0000028)4.45290758
6DNA strand elongation (GO:0022616)4.31023272
7telomere maintenance via semi-conservative replication (GO:0032201)4.20459846
8maturation of SSU-rRNA (GO:0030490)4.12458327
9viral transcription (GO:0019083)4.07024318
10DNA replication initiation (GO:0006270)4.06908784
11formation of translation preinitiation complex (GO:0001731)4.01854782
12DNA unwinding involved in DNA replication (GO:0006268)4.01500800
13translational termination (GO:0006415)3.98348630
14nucleobase biosynthetic process (GO:0046112)3.96724403
15tryptophan catabolic process (GO:0006569)3.86117364
16indole-containing compound catabolic process (GO:0042436)3.86117364
17indolalkylamine catabolic process (GO:0046218)3.86117364
18folic acid-containing compound biosynthetic process (GO:0009396)3.83935702
19DNA methylation involved in gamete generation (GO:0043046)3.81128486
20L-fucose catabolic process (GO:0042355)3.81095866
21fucose catabolic process (GO:0019317)3.81095866
22L-fucose metabolic process (GO:0042354)3.81095866
23purine nucleobase biosynthetic process (GO:0009113)3.79510542
24signal peptide processing (GO:0006465)3.76178409
25synapsis (GO:0007129)3.71127274
26telomere maintenance via recombination (GO:0000722)3.70735346
27indolalkylamine metabolic process (GO:0006586)3.68131727
28translational elongation (GO:0006414)3.67458809
29kynurenine metabolic process (GO:0070189)3.62279736
30ribosomal small subunit biogenesis (GO:0042274)3.58649637
31protein localization to kinetochore (GO:0034501)3.58346783
32DNA replication-dependent nucleosome organization (GO:0034723)3.57772606
33DNA replication-dependent nucleosome assembly (GO:0006335)3.57772606
34behavioral response to nicotine (GO:0035095)3.56603272
35translational initiation (GO:0006413)3.55695162
36neural tube formation (GO:0001841)3.52762831
37SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.49716663
38mitotic recombination (GO:0006312)3.48464431
39mitotic nuclear envelope disassembly (GO:0007077)3.47432148
40nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.45461602
41detection of light stimulus involved in sensory perception (GO:0050962)3.43319028
42detection of light stimulus involved in visual perception (GO:0050908)3.43319028
43tryptophan metabolic process (GO:0006568)3.41961477
44protein targeting to ER (GO:0045047)3.38768019
45cotranslational protein targeting to membrane (GO:0006613)3.37947339
46ribosome biogenesis (GO:0042254)3.36608051
47ribonucleoprotein complex biogenesis (GO:0022613)3.33215603
48protein localization to chromosome, centromeric region (GO:0071459)3.32423328
49DNA replication checkpoint (GO:0000076)3.30984061
50regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.30314508
51IMP biosynthetic process (GO:0006188)3.29678994
52regulation of meiosis I (GO:0060631)3.28411870
53positive regulation of defense response to virus by host (GO:0002230)3.28072369
54CENP-A containing nucleosome assembly (GO:0034080)3.27378726
55chromatin remodeling at centromere (GO:0031055)3.25728792
56nuclear envelope disassembly (GO:0051081)3.25269914
57membrane disassembly (GO:0030397)3.25269914
58negative regulation of mast cell activation (GO:0033004)3.23641554
59telomere maintenance via telomere lengthening (GO:0010833)3.22928024
60male meiosis I (GO:0007141)3.22852071
61DNA replication-independent nucleosome assembly (GO:0006336)3.21666572
62DNA replication-independent nucleosome organization (GO:0034724)3.21666572
63establishment of protein localization to endoplasmic reticulum (GO:0072599)3.19943452
64viral life cycle (GO:0019058)3.17286665
65ribosomal large subunit biogenesis (GO:0042273)3.16916749
66protein localization to endoplasmic reticulum (GO:0070972)3.16175958
67nuclear pore organization (GO:0006999)3.14750969
68regulation of DNA endoreduplication (GO:0032875)3.12313762
69establishment of protein localization to Golgi (GO:0072600)3.11460673
70folic acid metabolic process (GO:0046655)3.09195286
71mitotic metaphase plate congression (GO:0007080)3.09154668
72cellular protein complex disassembly (GO:0043624)3.08856922
73snRNA transcription (GO:0009301)3.08583379
74nucleotide-excision repair, DNA gap filling (GO:0006297)3.07265835
75monoubiquitinated protein deubiquitination (GO:0035520)3.05953116
76somatic hypermutation of immunoglobulin genes (GO:0016446)3.03087099
77somatic diversification of immune receptors via somatic mutation (GO:0002566)3.03087099
78rRNA processing (GO:0006364)3.02767763
79ribosome assembly (GO:0042255)3.00529278
80nuclear pore complex assembly (GO:0051292)2.99840988
81IMP metabolic process (GO:0046040)2.97408399
82cytoplasmic mRNA processing body assembly (GO:0033962)2.95958064
83reciprocal meiotic recombination (GO:0007131)2.95698642
84reciprocal DNA recombination (GO:0035825)2.95698642
85mitotic chromosome condensation (GO:0007076)2.94606879
86rRNA catabolic process (GO:0016075)2.94222977
87rRNA metabolic process (GO:0016072)2.93530567
88activated T cell proliferation (GO:0050798)2.92594568
89histone exchange (GO:0043486)2.91627833
90protein K63-linked deubiquitination (GO:0070536)2.90869343
91interferon-gamma production (GO:0032609)2.89697727
92negative regulation of DNA-dependent DNA replication (GO:2000104)2.89588723
93viral mRNA export from host cell nucleus (GO:0046784)2.88849634
94translesion synthesis (GO:0019985)2.88733177
95protein complex disassembly (GO:0043241)2.88487895
96cellular response to interleukin-15 (GO:0071350)2.87230935
97male meiosis (GO:0007140)2.86146427
98regulation of memory T cell differentiation (GO:0043380)2.85299163
99regulation of histone H3-K9 methylation (GO:0051570)2.85103943
100nuclear-transcribed mRNA catabolic process (GO:0000956)2.84575120
101chromatin assembly or disassembly (GO:0006333)2.82393932
102cornea development in camera-type eye (GO:0061303)2.82029141
103regulation of spindle organization (GO:0090224)2.78620760
104detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.77841881
105RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.75609815
106spliceosomal snRNP assembly (GO:0000387)2.74880826
107adaptation of signaling pathway (GO:0023058)2.74708285
108double-strand break repair via homologous recombination (GO:0000724)2.73978704
109recombinational repair (GO:0000725)2.73870856
110RNA catabolic process (GO:0006401)2.72823445
111histone H3-K9 methylation (GO:0051567)2.71974172
112mRNA catabolic process (GO:0006402)2.71398254
113protein targeting to Golgi (GO:0000042)2.71187484
114macromolecular complex disassembly (GO:0032984)2.70573746
115negative regulation of interleukin-1 beta production (GO:0032691)2.69466871
116antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.69161864
117antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.69161864
118negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.65989788
119positive regulation of protein homooligomerization (GO:0032464)2.65262698
120amine catabolic process (GO:0009310)2.65091282
121cellular biogenic amine catabolic process (GO:0042402)2.65091282
122metaphase plate congression (GO:0051310)2.65039193
123interkinetic nuclear migration (GO:0022027)2.64916868
124gene silencing by RNA (GO:0031047)2.64752225
125cellular response to ATP (GO:0071318)2.63035543
126protein K48-linked deubiquitination (GO:0071108)2.62244968
127negative regulation of RNA splicing (GO:0033119)2.61574453
128pteridine-containing compound biosynthetic process (GO:0042559)2.61520535
129DNA duplex unwinding (GO:0032508)2.61411099
130pseudouridine synthesis (GO:0001522)2.59769149
131histone H2A ubiquitination (GO:0033522)2.59617631
132attachment of spindle microtubules to kinetochore (GO:0008608)2.59499110
133DNA geometric change (GO:0032392)2.59179070
134positive regulation of T-helper 1 type immune response (GO:0002827)2.58312194
135translation (GO:0006412)2.57868172
136mismatch repair (GO:0006298)2.57318405
137protein K6-linked ubiquitination (GO:0085020)2.57030146
138dosage compensation (GO:0007549)2.56526857
139DNA double-strand break processing (GO:0000729)2.56423661
140ATP-dependent chromatin remodeling (GO:0043044)2.54536829
141peptidyl-lysine trimethylation (GO:0018023)2.52917645
142histone H2A acetylation (GO:0043968)2.51795069
143indole-containing compound metabolic process (GO:0042430)2.51606022
144rRNA modification (GO:0000154)2.51411212
145deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.51031502
146regulation of interleukin-12 biosynthetic process (GO:0045075)2.50883478
147postreplication repair (GO:0006301)2.50826525
148G1/S transition of mitotic cell cycle (GO:0000082)2.48952042
149cell cycle G1/S phase transition (GO:0044843)2.48952042
150tolerance induction (GO:0002507)2.48824446
151nuclear envelope organization (GO:0006998)2.48685503
152base-excision repair (GO:0006284)2.47875322
153retrograde transport, vesicle recycling within Golgi (GO:0000301)2.47822079
154negative regulation of cAMP-mediated signaling (GO:0043951)2.47662954
155somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.47376501
156isotype switching (GO:0045190)2.47376501
157somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.47376501
158negative regulation of interleukin-1 production (GO:0032692)2.47372176
159telomere maintenance (GO:0000723)2.47279279
160telomere organization (GO:0032200)2.47093779
161meiosis I (GO:0007127)2.47067659
162retinal cone cell development (GO:0046549)2.46674778
163mitotic G1 DNA damage checkpoint (GO:0031571)2.46354475
164mitotic sister chromatid segregation (GO:0000070)2.46063819
165regulation of MHC class I biosynthetic process (GO:0045343)2.45777681
166regulation of double-strand break repair via homologous recombination (GO:0010569)2.43483481
167peptidyl-threonine dephosphorylation (GO:0035970)2.43195638
168meiotic chromosome segregation (GO:0045132)2.42469387
169positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.42438549
170histone H3-K9 modification (GO:0061647)2.41896952
171response to interleukin-15 (GO:0070672)2.41004290
172negative regulation of systemic arterial blood pressure (GO:0003085)2.39907706
173keratinocyte development (GO:0003334)2.39175083
174microtubule anchoring (GO:0034453)2.37476607
175negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.37350813
176negative regulation of translation, ncRNA-mediated (GO:0040033)2.37350813
177regulation of translation, ncRNA-mediated (GO:0045974)2.37350813
178RNA destabilization (GO:0050779)2.36493132
179epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.35532346
180regulation of defense response to virus by host (GO:0050691)2.34582672
181positive regulation of heat generation (GO:0031652)2.34220189
182meiotic cell cycle (GO:0051321)2.33236363
183regulation of hippo signaling (GO:0035330)2.32160666
184tachykinin receptor signaling pathway (GO:0007217)2.30853793
185preassembly of GPI anchor in ER membrane (GO:0016254)2.30368215
186protein-cofactor linkage (GO:0018065)2.29412358
187kidney morphogenesis (GO:0060993)2.28535079
188protein localization to Golgi apparatus (GO:0034067)2.26339732
189positive regulation of cell fate commitment (GO:0010455)2.25267822
190centriole replication (GO:0007099)2.24962607
191regulation of heat generation (GO:0031650)2.23782126
192negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.23635129
193negative regulation of T-helper cell differentiation (GO:0045623)2.23635129
194cAMP catabolic process (GO:0006198)2.23280835
195photoreceptor cell development (GO:0042461)2.23122072

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.58198215
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.74729594
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.63164179
4ZNF274_21170338_ChIP-Seq_K562_Hela3.50842126
5* FOXM1_23109430_ChIP-Seq_U2OS_Human3.25485180
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.15173980
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.00510265
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.82482519
9VDR_22108803_ChIP-Seq_LS180_Human2.72187290
10IGF1R_20145208_ChIP-Seq_DFB_Human2.68291419
11* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.67181450
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.65306297
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.56098816
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.50198511
15EWS_26573619_Chip-Seq_HEK293_Human2.49676824
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.43354085
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.43101856
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.41702297
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.37013947
20TAF15_26573619_Chip-Seq_HEK293_Human2.35527187
21* GABP_17652178_ChIP-ChIP_JURKAT_Human2.33809031
22EST1_17652178_ChIP-ChIP_JURKAT_Human2.31665501
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.31022366
24EGR1_19374776_ChIP-ChIP_THP-1_Human2.29699418
25KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.29365830
26* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.29182566
27FLI1_27457419_Chip-Seq_LIVER_Mouse2.27999909
28* ETS1_20019798_ChIP-Seq_JURKAT_Human2.27333347
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.24621746
30MYC_22102868_ChIP-Seq_BL_Human2.23441154
31GBX2_23144817_ChIP-Seq_PC3_Human2.15782260
32CREB1_15753290_ChIP-ChIP_HEK293T_Human2.15611901
33* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.07565805
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.07464668
35XRN2_22483619_ChIP-Seq_HELA_Human2.07450231
36ELF1_17652178_ChIP-ChIP_JURKAT_Human2.06890839
37VDR_23849224_ChIP-Seq_CD4+_Human2.06299415
38FUS_26573619_Chip-Seq_HEK293_Human2.05344401
39ER_23166858_ChIP-Seq_MCF-7_Human1.97755668
40HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.95013694
41FOXP3_21729870_ChIP-Seq_TREG_Human1.90699943
42* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.90082202
43STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.87226530
44P300_19829295_ChIP-Seq_ESCs_Human1.81459410
45CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.79933374
46NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.77188221
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77024644
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.73963186
49* GABP_19822575_ChIP-Seq_HepG2_Human1.73379093
50* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.72045069
51DCP1A_22483619_ChIP-Seq_HELA_Human1.71939451
52* E2F1_21310950_ChIP-Seq_MCF-7_Human1.70774764
53RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68581441
54ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.68235401
55MYCN_18555785_ChIP-Seq_MESCs_Mouse1.68210513
56AR_21909140_ChIP-Seq_LNCAP_Human1.65872152
57UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.64913872
58SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.63484699
59AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.61914109
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59257147
61* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.58142056
62VDR_21846776_ChIP-Seq_THP-1_Human1.57422935
63CIITA_25753668_ChIP-Seq_RAJI_Human1.56931546
64MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.56749013
65CTBP2_25329375_ChIP-Seq_LNCAP_Human1.56601236
66ZFX_18555785_ChIP-Seq_MESCs_Mouse1.53801542
67TTF2_22483619_ChIP-Seq_HELA_Human1.53543619
68* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.51564227
69POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.50516495
70STAT3_23295773_ChIP-Seq_U87_Human1.49482272
71HOXB4_20404135_ChIP-ChIP_EML_Mouse1.47830223
72EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.47102217
73GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.46548882
74* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.46258686
75MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46060297
76BCAT_22108803_ChIP-Seq_LS180_Human1.45791900
77FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.45107418
78IRF8_21731497_ChIP-ChIP_J774_Mouse1.44828573
79TP53_22573176_ChIP-Seq_HFKS_Human1.43540884
80NANOG_18555785_ChIP-Seq_MESCs_Mouse1.43276329
81SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42675404
82CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40643540
83EZH2_27294783_Chip-Seq_NPCs_Mouse1.37485817
84* KDM5A_27292631_Chip-Seq_BREAST_Human1.37282499
85MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37146845
86IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.34026839
87ELK1_19687146_ChIP-ChIP_HELA_Human1.33019064
88IRF1_19129219_ChIP-ChIP_H3396_Human1.32759568
89MYC_18940864_ChIP-ChIP_HL60_Human1.32654636
90STAT3_1855785_ChIP-Seq_MESCs_Mouse1.32548194
91TCF4_23295773_ChIP-Seq_U87_Human1.32022699
92TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30422400
93POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30422400
94FLI1_21867929_ChIP-Seq_TH2_Mouse1.30335998
95IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30161198
96CBP_20019798_ChIP-Seq_JUKART_Human1.30161198
97PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30129113
98* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.29273849
99SPI1_23547873_ChIP-Seq_NB4_Human1.28004401
100SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27929302
101THAP11_20581084_ChIP-Seq_MESCs_Mouse1.27693666
102MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.27426103
103RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.26729017
104NOTCH1_21737748_ChIP-Seq_TLL_Human1.26527413
105NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26283812
106* TFEB_21752829_ChIP-Seq_HELA_Human1.25680380
107ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.25070002
108GATA3_26560356_Chip-Seq_TH2_Human1.25067886
109PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23790146
110PIAS1_25552417_ChIP-Seq_VCAP_Human1.23755501
111MYB_21317192_ChIP-Seq_ERMYB_Mouse1.23630868
112NFE2_27457419_Chip-Seq_LIVER_Mouse1.23337826
113IRF8_22096565_ChIP-ChIP_GC-B_Human1.22561612
114TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21656386
115SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.20673439
116* SMAD4_21799915_ChIP-Seq_A2780_Human1.20111440
117TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19554706
118* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19237546
119CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.18403115
120* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.18120512
121DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17283770
122* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.17208118
123SRF_21415370_ChIP-Seq_HL-1_Mouse1.16831703
124SCL_19346495_ChIP-Seq_HPC-7_Human1.16620970
125CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.16230202
126EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.15232809
127* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14821182
128AR_25329375_ChIP-Seq_VCAP_Human1.14585783
129TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13221752
130SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13072637
131YY1_21170310_ChIP-Seq_MESCs_Mouse1.12505718
132CDX2_22108803_ChIP-Seq_LS180_Human1.12423207
133NANOG_19829295_ChIP-Seq_ESCs_Human1.11988827
134SOX2_19829295_ChIP-Seq_ESCs_Human1.11988827
135RUNX2_22187159_ChIP-Seq_PCA_Human1.11248516
136TP63_19390658_ChIP-ChIP_HaCaT_Human1.10565445
137PRDM14_20953172_ChIP-Seq_ESCs_Human1.09706923
138STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.09439702
139GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.09128512
140SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08844062
141GATA1_22025678_ChIP-Seq_K562_Human1.08588175
142NANOG_18555785_Chip-Seq_ESCs_Mouse1.08075069
143SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.07827794
144YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07534023
145MYB_26560356_Chip-Seq_TH2_Human1.07084734
146* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.06907800
147CRX_20693478_ChIP-Seq_RETINA_Mouse1.06274270
148TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05683740
149RUNX_20019798_ChIP-Seq_JUKART_Human1.05606573
150OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05235263
151MYB_26560356_Chip-Seq_TH1_Human1.05061157
152GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05008833
153SMAD3_21741376_ChIP-Seq_EPCs_Human1.04997562
154UTX_26944678_Chip-Seq_JUKART_Human1.04795517
155GATA3_26560356_Chip-Seq_TH1_Human1.04732960
156MAF_26560356_Chip-Seq_TH1_Human1.04636312
157TCF4_22108803_ChIP-Seq_LS180_Human1.04606412
158SMAD_19615063_ChIP-ChIP_OVARY_Human1.04465513
159CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03823687
160* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03627780
161* FOXA1_25329375_ChIP-Seq_VCAP_Human1.03627780
162* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.02951838
163RUNX1_22412390_ChIP-Seq_EML_Mouse1.02415251
164SMRT_27268052_Chip-Seq_Bcells_Human1.00900515
165GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00078108
166POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.99521579
167BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99519359
168CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98368174
169RNF2_27304074_Chip-Seq_NSC_Mouse0.96548353
170EGR1_23403033_ChIP-Seq_LIVER_Mouse0.96452866
171TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.95809956
172CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.95568655
173POU5F1_16153702_ChIP-ChIP_HESCs_Human0.95533838
174E2F1_18555785_Chip-Seq_ESCs_Mouse0.94864122
175GATA3_21878914_ChIP-Seq_MCF-7_Human0.94699130
176CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94689091
177MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.94677560
178BRD4_27068464_Chip-Seq_AML-cells_Mouse0.94375286
179EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94045775
180PADI4_21655091_ChIP-ChIP_MCF-7_Human0.93322525
181FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.93077700
182CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.92305245
183STAT4_19710469_ChIP-ChIP_TH1__Mouse0.91321062
184GATA2_22383799_ChIP-Seq_G1ME_Mouse0.91012768
185TCF7_22412390_ChIP-Seq_EML_Mouse0.90569410
186KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.90220426

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.08917823
2MP0010094_abnormal_chromosome_stability3.68760857
3MP0003111_abnormal_nucleus_morphology3.40969528
4MP0004957_abnormal_blastocyst_morpholog3.40182515
5MP0008057_abnormal_DNA_replication3.30625626
6MP0003077_abnormal_cell_cycle3.14880660
7MP0002396_abnormal_hematopoietic_system2.80354543
8MP0000569_abnormal_digit_pigmentation2.76610866
9MP0003195_calcinosis2.73361200
10MP0008058_abnormal_DNA_repair2.64127024
11MP0008007_abnormal_cellular_replicative2.58327008
12MP0002102_abnormal_ear_morphology2.56899271
13MP0002653_abnormal_ependyma_morphology2.53757254
14MP0003787_abnormal_imprinting2.47344047
15MP0000372_irregular_coat_pigmentation2.39033177
16MP0010352_gastrointestinal_tract_polyps2.35783993
17MP0002138_abnormal_hepatobiliary_system2.32830634
18MP0002277_abnormal_respiratory_mucosa2.24266040
19MP0002009_preneoplasia2.16116742
20MP0003646_muscle_fatigue2.13066281
21MP0004808_abnormal_hematopoietic_stem2.08365709
22MP0005397_hematopoietic_system_phenotyp2.06226082
23MP0001545_abnormal_hematopoietic_system2.06226082
24MP0000490_abnormal_crypts_of2.00683304
25MP0005310_abnormal_salivary_gland1.92799913
26MP0003763_abnormal_thymus_physiology1.90810285
27MP0005174_abnormal_tail_pigmentation1.89987767
28MP0000685_abnormal_immune_system1.84906240
29MP0001919_abnormal_reproductive_system1.84855959
30MP0000427_abnormal_hair_cycle1.84657885
31MP0001835_abnormal_antigen_presentation1.83663573
32MP0010307_abnormal_tumor_latency1.83227988
33MP0000350_abnormal_cell_proliferation1.83163627
34MP0005389_reproductive_system_phenotype1.79233611
35MP0002254_reproductive_system_inflammat1.78274337
36MP0002398_abnormal_bone_marrow1.77812661
37MP0001730_embryonic_growth_arrest1.76614351
38MP0009333_abnormal_splenocyte_physiolog1.73730080
39MP0005551_abnormal_eye_electrophysiolog1.72446767
40MP0008932_abnormal_embryonic_tissue1.69877350
41MP0004142_abnormal_muscle_tone1.68941870
42MP0003136_yellow_coat_color1.66956494
43MP0004381_abnormal_hair_follicle1.64899371
44MP0003786_premature_aging1.63914611
45MP0008961_abnormal_basal_metabolism1.62250439
46MP0008877_abnormal_DNA_methylation1.62142259
47MP0003436_decreased_susceptibility_to1.60205947
48MP0005671_abnormal_response_to1.60117535
49MP0006292_abnormal_olfactory_placode1.59711094
50MP0000383_abnormal_hair_follicle1.59330747
51MP0002163_abnormal_gland_morphology1.57450886
52MP0000689_abnormal_spleen_morphology1.56552963
53MP0002722_abnormal_immune_system1.56192438
54MP0002019_abnormal_tumor_incidence1.55356377
55MP0001800_abnormal_humoral_immune1.52274254
56MP0002160_abnormal_reproductive_system1.51071252
57MP0002837_dystrophic_cardiac_calcinosis1.50438570
58MP0009278_abnormal_bone_marrow1.49666135
59MP0000371_diluted_coat_color1.49091110
60MP0003890_abnormal_embryonic-extraembry1.46954811
61MP0003123_paternal_imprinting1.44282405
62MP0000703_abnormal_thymus_morphology1.44101848
63MP0002429_abnormal_blood_cell1.37412674
64MP0000313_abnormal_cell_death1.35279791
65MP0001697_abnormal_embryo_size1.34895587
66MP0000716_abnormal_immune_system1.34397983
67MP0005075_abnormal_melanosome_morpholog1.33008005
68MP0002420_abnormal_adaptive_immunity1.31337014
69MP0009379_abnormal_foot_pigmentation1.30380673
70MP0002452_abnormal_antigen_presenting1.30262855
71MP0005253_abnormal_eye_physiology1.30202097
72MP0002080_prenatal_lethality1.30020991
73MP0009785_altered_susceptibility_to1.29388248
74MP0001819_abnormal_immune_cell1.29027802
75MP0003724_increased_susceptibility_to1.27914072
76MP0001672_abnormal_embryogenesis/_devel1.27341628
77MP0005380_embryogenesis_phenotype1.27341628
78MP0002723_abnormal_immune_serum1.24673726
79MP0008995_early_reproductive_senescence1.23397385
80MP0002166_altered_tumor_susceptibility1.22617790
81MP0003984_embryonic_growth_retardation1.22420530
82MP0009046_muscle_twitch1.21555187
83MP0002928_abnormal_bile_duct1.21128328
84MP0002086_abnormal_extraembryonic_tissu1.20113974
85MP0002405_respiratory_system_inflammati1.19952112
86MP0002088_abnormal_embryonic_growth/wei1.19821606
87MP0009764_decreased_sensitivity_to1.19810930
88MP0010155_abnormal_intestine_physiology1.18809825
89MP0006054_spinal_hemorrhage1.18579231
90MP0000858_altered_metastatic_potential1.16702968
91MP0005000_abnormal_immune_tolerance1.16491194
92MP0005025_abnormal_response_to1.15435965
93MP0002638_abnormal_pupillary_reflex1.14533424
94MP0001873_stomach_inflammation1.13750660
95MP0002148_abnormal_hypersensitivity_rea1.13247572
96MP0005464_abnormal_platelet_physiology1.11418678
97MP0005647_abnormal_sex_gland1.10019945
98MP0001324_abnormal_eye_pigmentation1.09968318
99MP0002736_abnormal_nociception_after1.09360825
100MP0001968_abnormal_touch/_nociception1.08566149
101MP0003806_abnormal_nucleotide_metabolis1.07601269
102MP0000015_abnormal_ear_pigmentation1.06485864
103MP0004043_abnormal_pH_regulation1.05970124
104MP0006072_abnormal_retinal_apoptosis1.05341430
105MP0008875_abnormal_xenobiotic_pharmacok1.04057561
106MP0001188_hyperpigmentation1.03393427
107MP0001119_abnormal_female_reproductive1.02874328
108MP0005379_endocrine/exocrine_gland_phen1.01771063
109MP0001501_abnormal_sleep_pattern1.01632235
110MP0003567_abnormal_fetal_cardiomyocyte1.01289304
111MP0002085_abnormal_embryonic_tissue0.99171989
112MP0000358_abnormal_cell_content/0.99060040
113MP0005076_abnormal_cell_differentiation0.98683010
114MP0002210_abnormal_sex_determination0.98648605
115MP0004197_abnormal_fetal_growth/weight/0.98287056
116MP0001929_abnormal_gametogenesis0.97725048
117MP0001853_heart_inflammation0.97221097
118MP0000631_abnormal_neuroendocrine_gland0.97183381
119MP0005266_abnormal_metabolism0.95277054
120MP0002132_abnormal_respiratory_system0.94181178
121MP0000465_gastrointestinal_hemorrhage0.94048923
122MP0003943_abnormal_hepatobiliary_system0.93238478
123MP0002877_abnormal_melanocyte_morpholog0.92787969
124MP0005023_abnormal_wound_healing0.92715384
125MP0002006_tumorigenesis0.92197425
126MP0003866_abnormal_defecation0.91973376
127MP0002084_abnormal_developmental_patter0.90609823
128MP0001790_abnormal_immune_system0.90527641
129MP0005387_immune_system_phenotype0.90527641
130MP0002938_white_spotting0.90493362
131MP0001145_abnormal_male_reproductive0.89313632
132MP0004264_abnormal_extraembryonic_tissu0.88727778
133MP0008872_abnormal_physiological_respon0.88031222
134MP0002735_abnormal_chemical_nociception0.87983281
135MP0010678_abnormal_skin_adnexa0.87870948
136MP0000477_abnormal_intestine_morphology0.87458872
137MP0002419_abnormal_innate_immunity0.85580639
138MP0001845_abnormal_inflammatory_respons0.85379975
139MP0004947_skin_inflammation0.83823112
140MP0003698_abnormal_male_reproductive0.81931200
141MP0002095_abnormal_skin_pigmentation0.81875987
142MP0000598_abnormal_liver_morphology0.81694024
143MP0002693_abnormal_pancreas_physiology0.79779879
144MP0005167_abnormal_blood-brain_barrier0.79109738
145MP0000647_abnormal_sebaceous_gland0.78702326
146MP0005384_cellular_phenotype0.78619008
147MP0003186_abnormal_redox_activity0.78594289
148MP0002075_abnormal_coat/hair_pigmentati0.77934379
149MP0005621_abnormal_cell_physiology0.76937517
150MP0005410_abnormal_fertilization0.76407914
151MP0003705_abnormal_hypodermis_morpholog0.75265781
152MP0003656_abnormal_erythrocyte_physiolo0.75153517
153MP0006082_CNS_inflammation0.74884292
154MP0002332_abnormal_exercise_endurance0.73885965
155MP0009672_abnormal_birth_weight0.72550275
156MP0000653_abnormal_sex_gland0.72066374
157MP0001186_pigmentation_phenotype0.71126748
158MP0003300_gastrointestinal_ulcer0.70784873
159MP0003121_genomic_imprinting0.70348427
160MP0003718_maternal_effect0.69945374
161MP0003303_peritoneal_inflammation0.68753214
162MP0001915_intracranial_hemorrhage0.68198861

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.70018430
2Abnormal number of erythroid precursors (HP:0012131)4.52306282
3Pancreatic cysts (HP:0001737)4.41507561
4Reticulocytopenia (HP:0001896)4.18571570
5Birth length less than 3rd percentile (HP:0003561)3.97375808
6Pancreatic fibrosis (HP:0100732)3.91122360
7Congenital stationary night blindness (HP:0007642)3.89910896
8Abnormality of midbrain morphology (HP:0002418)3.57491209
9Molar tooth sign on MRI (HP:0002419)3.57491209
10True hermaphroditism (HP:0010459)3.52002973
11Aplastic anemia (HP:0001915)3.49914947
12Stomatitis (HP:0010280)3.46376248
13Thrombocytosis (HP:0001894)3.41690216
14Chronic hepatic failure (HP:0100626)3.32292360
15Ependymoma (HP:0002888)3.24190247
1611 pairs of ribs (HP:0000878)3.19466934
17Selective tooth agenesis (HP:0001592)3.15747575
18Agnosia (HP:0010524)3.13011647
19Degeneration of anterior horn cells (HP:0002398)3.06647286
20Abnormality of the anterior horn cell (HP:0006802)3.06647286
21Abnormality of the renal cortex (HP:0011035)3.02144164
22Pallor (HP:0000980)2.98731745
23Retrobulbar optic neuritis (HP:0100654)2.96871562
24Optic neuritis (HP:0100653)2.96871562
25IgM deficiency (HP:0002850)2.86946078
26Macrocytic anemia (HP:0001972)2.85661986
27Stomach cancer (HP:0012126)2.82627173
28Tubular atrophy (HP:0000092)2.75103963
29Oral leukoplakia (HP:0002745)2.74491131
30Medulloblastoma (HP:0002885)2.73660872
31Genetic anticipation (HP:0003743)2.72086778
32Nasal polyposis (HP:0100582)2.69159845
33Myelodysplasia (HP:0002863)2.67048824
34Recurrent bronchitis (HP:0002837)2.65017846
35Basal cell carcinoma (HP:0002671)2.64566817
36Nephronophthisis (HP:0000090)2.62733818
37Aplasia/Hypoplasia of the tibia (HP:0005772)2.62131253
38Keratoconjunctivitis (HP:0001096)2.61437502
39Breast hypoplasia (HP:0003187)2.59122064
40Bile duct proliferation (HP:0001408)2.56006411
41Abnormal biliary tract physiology (HP:0012439)2.56006411
42Microretrognathia (HP:0000308)2.54650755
43Type II lissencephaly (HP:0007260)2.52534903
44Attenuation of retinal blood vessels (HP:0007843)2.50588190
45Abnormality of the renal medulla (HP:0100957)2.50442253
46Abnormality of chromosome stability (HP:0003220)2.43559264
47Hyperventilation (HP:0002883)2.41340891
48Medial flaring of the eyebrow (HP:0010747)2.40749407
49Gaze-evoked nystagmus (HP:0000640)2.39664945
50Multiple enchondromatosis (HP:0005701)2.39486065
51Amaurosis fugax (HP:0100576)2.38884869
52Polydipsia (HP:0001959)2.38733223
53Abnormal drinking behavior (HP:0030082)2.38733223
54Absent thumb (HP:0009777)2.38607402
55Abnormality of the heme biosynthetic pathway (HP:0010472)2.37912959
56Keratoconjunctivitis sicca (HP:0001097)2.37379339
57Decreased central vision (HP:0007663)2.36783902
58Lymphoma (HP:0002665)2.36776733
59Abnormality of the preputium (HP:0100587)2.35049182
60Cystic liver disease (HP:0006706)2.34060908
61Carpal bone hypoplasia (HP:0001498)2.33683182
62Abnormality of the nasal mucosa (HP:0000433)2.33194679
63Rhabdomyosarcoma (HP:0002859)2.32182702
64Rough bone trabeculation (HP:0100670)2.30290563
65Abnormal rod and cone electroretinograms (HP:0008323)2.29710978
66Colon cancer (HP:0003003)2.28806803
67Volvulus (HP:0002580)2.28697790
68Orchitis (HP:0100796)2.27539192
69Chronic otitis media (HP:0000389)2.25379290
70Petechiae (HP:0000967)2.23756101
71Recurrent viral infections (HP:0004429)2.23545069
72Acute myeloid leukemia (HP:0004808)2.22178243
73Fair hair (HP:0002286)2.20844922
74Abnormality of T cells (HP:0002843)2.20838278
75Hypoplasia of the fovea (HP:0007750)2.20506388
76Aplasia/Hypoplasia of the fovea (HP:0008060)2.20506388
77Abnormality of T cell physiology (HP:0011840)2.19289286
78Meckel diverticulum (HP:0002245)2.18724411
79Furrowed tongue (HP:0000221)2.18378968
80Alveolar cell carcinoma (HP:0006519)2.17137212
81Type I transferrin isoform profile (HP:0003642)2.16445462
82Neoplasm of the tracheobronchial system (HP:0100552)2.15673093
83Neoplasm of the pancreas (HP:0002894)2.14730869
84Chromsome breakage (HP:0040012)2.14627489
85Bone marrow hypocellularity (HP:0005528)2.14415355
86Abnormality of DNA repair (HP:0003254)2.13527160
87Oligodactyly (hands) (HP:0001180)2.12470949
88Aplasia/Hypoplasia of the tongue (HP:0010295)2.12470266
89Patellar aplasia (HP:0006443)2.12449398
90Aplasia/Hypoplasia of the uvula (HP:0010293)2.12409046
91Increased neuronal autofluorescent lipopigment (HP:0002074)2.11889187
92Absent rod-and cone-mediated responses on ERG (HP:0007688)2.09434083
93Chromosomal breakage induced by crosslinking agents (HP:0003221)2.08533437
94T lymphocytopenia (HP:0005403)2.08473802
95Abnormality of alanine metabolism (HP:0010916)2.07921962
96Hyperalaninemia (HP:0003348)2.07921962
97Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.07921962
98B lymphocytopenia (HP:0010976)2.07592112
99Abnormality of B cell number (HP:0010975)2.07592112
100Abnormality of the ileum (HP:0001549)2.07368278
101Prominent nose (HP:0000448)2.07325166
102Cerebellar dysplasia (HP:0007033)2.06242591
103Concave nail (HP:0001598)2.06115595
104Progressive inability to walk (HP:0002505)2.04948802
105Abolished electroretinogram (ERG) (HP:0000550)2.04889582
106Poikiloderma (HP:0001029)2.04354473
107Duodenal stenosis (HP:0100867)2.03422489
108Small intestinal stenosis (HP:0012848)2.03422489
109Albinism (HP:0001022)2.03076571
110Abnormality of the renal collecting system (HP:0004742)2.01725013
111Abnormality of reticulocytes (HP:0004312)2.00310227
112Keratitis (HP:0000491)2.00298925
113Missing ribs (HP:0000921)2.00207014
114Acute lymphatic leukemia (HP:0006721)2.00160453
115Anencephaly (HP:0002323)1.98947752
116Thyroiditis (HP:0100646)1.98505060
117Short tibia (HP:0005736)1.97375589
118Premature graying of hair (HP:0002216)1.96949436
119Azoospermia (HP:0000027)1.95277720
120Aplasia/Hypoplasia of the patella (HP:0006498)1.95225088
121Trismus (HP:0000211)1.94516550
122Elevated erythrocyte sedimentation rate (HP:0003565)1.94510182
123Bronchitis (HP:0012387)1.94300387
124Panhypogammaglobulinemia (HP:0003139)1.92170362
125Entropion (HP:0000621)1.92036647
126Abnormality of T cell number (HP:0011839)1.90277101
127Pancytopenia (HP:0001876)1.90255174
128Myositis (HP:0100614)1.90198803
129Congenital hepatic fibrosis (HP:0002612)1.90032328
130Progressive cerebellar ataxia (HP:0002073)1.89841371
131Febrile seizures (HP:0002373)1.89563741
132Impulsivity (HP:0100710)1.86446190
133Progressive muscle weakness (HP:0003323)1.86327186
134Recurrent fungal infections (HP:0002841)1.86294385
135IgG deficiency (HP:0004315)1.86244279
136Sloping forehead (HP:0000340)1.85563502
137Renal cortical cysts (HP:0000803)1.85097374
138Male pseudohermaphroditism (HP:0000037)1.84524599
139Atrophy/Degeneration involving motor neurons (HP:0007373)1.84285175
140Generalized hypopigmentation of hair (HP:0011358)1.83265310
141Pustule (HP:0200039)1.81983035
142Increased cerebral lipofuscin (HP:0011813)1.81854374
143Abnormality of the pons (HP:0007361)1.81427891
144Inability to walk (HP:0002540)1.81366742
145Hypoplasia of the thymus (HP:0000778)1.81094770
146Cerebral hypomyelination (HP:0006808)1.81084724
147Congenital primary aphakia (HP:0007707)1.80956471
148Abnormality of the calcaneus (HP:0008364)1.80766178
149Intestinal atresia (HP:0011100)1.78971828
150Combined immunodeficiency (HP:0005387)1.78890001
151Abnormality of cells of the lymphoid lineage (HP:0012140)1.78223774
152Abnormal spermatogenesis (HP:0008669)1.77810869
153Duplicated collecting system (HP:0000081)1.77067588
154Abnormality of the astrocytes (HP:0100707)1.76190001
155Astrocytoma (HP:0009592)1.76190001
156Abnormality of the duodenum (HP:0002246)1.75695125
157Premature ovarian failure (HP:0008209)1.75083401
158Protruding tongue (HP:0010808)1.74841451
159Cellulitis (HP:0100658)1.74808250
160Leukopenia (HP:0001882)1.74565359
161Large for gestational age (HP:0001520)1.73882648
162Secondary amenorrhea (HP:0000869)1.73547056
163Gait imbalance (HP:0002141)1.72777353
164Aplasia/Hypoplasia of the thymus (HP:0010515)1.72588271
165Poor head control (HP:0002421)1.72565999
166Reduced antithrombin III activity (HP:0001976)1.71716981
167Cafe-au-lait spot (HP:0000957)1.70700590
168Nephrogenic diabetes insipidus (HP:0009806)1.70601428
169Supernumerary spleens (HP:0009799)1.70037299
170Lissencephaly (HP:0001339)1.69850624
171Lymphopenia (HP:0001888)1.69462711
172Abnormal glycosylation (HP:0012345)1.69438528
173Abnormal protein N-linked glycosylation (HP:0012347)1.69438528
174Pendular nystagmus (HP:0012043)1.69212155
175Abnormality of the fovea (HP:0000493)1.66039863
176Optic nerve hypoplasia (HP:0000609)1.65180744
177Hematochezia (HP:0002573)1.64027271
178Abnormal delayed hypersensitivity skin test (HP:0002963)1.63546555
179Sclerocornea (HP:0000647)1.63194277
180Clubbing of toes (HP:0100760)1.62687938
181Anhidrosis (HP:0000970)1.62221439
182Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.61844949
183Widely spaced teeth (HP:0000687)1.61365162
184Polyuria (HP:0000103)1.60642351
185Astigmatism (HP:0000483)1.60391920
186Abnormal biliary tract morphology (HP:0012440)1.59741470
187Clumsiness (HP:0002312)1.58610255
188Absent/shortened dynein arms (HP:0200106)1.57926899
189Dynein arm defect of respiratory motile cilia (HP:0012255)1.57926899
190Increased corneal curvature (HP:0100692)1.57583548

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.54165274
2WEE13.81976473
3CDC73.10167449
4BUB12.97671099
5NEK22.90780823
6MAP3K102.51973090
7TAOK32.51518282
8AKT32.49429857
9BMPR1B2.42536961
10ADRBK22.42469575
11TRIM282.28497806
12EIF2AK12.26835096
13DYRK32.18937750
14ACVR1B2.14999157
15NME22.14526599
16EEF2K2.01872116
17IRAK11.95793049
18MAP4K21.95266974
19EIF2AK31.94265157
20FLT31.93837222
21NUAK11.92541371
22MAP4K11.90106126
23BRSK21.85710870
24NEK11.81649755
25RPS6KA41.81611254
26TRIB31.74902224
27PASK1.74651215
28PDK21.73820138
29VRK11.73569048
30SCYL21.69600003
31KIT1.69013814
32PKN21.60415427
33PIK3CG1.58608843
34IKBKE1.58486210
35CDK41.54188222
36MAP2K31.49801403
37GRK11.49272301
38TSSK61.49163772
39RPS6KB21.48286621
40TGFBR11.48023365
41WNK31.47771429
42CDK71.46300323
43SRPK11.45255350
44STK101.44017725
45TESK21.40692045
46ATR1.40419915
47MAPK131.38412182
48KDR1.35319799
49TTK1.31810277
50TYK21.31285376
51PIM21.30530976
52WNK41.28966143
53PLK11.27511884
54MARK31.27291777
55LRRK21.25011949
56PNCK1.24110337
57AURKB1.21100318
58MAP3K81.19959897
59STK161.19564256
60PIM11.17205134
61ZAP701.16411983
62TLK11.13214136
63BRD41.13073445
64STK38L1.12409956
65PLK41.09966456
66PAK31.09772668
67MAP3K141.09668512
68MAP3K41.07632353
69STK41.04023463
70BTK1.02715904
71EPHA21.02262052
72JAK31.01383083
73CDK120.99278926
74TNIK0.98396720
75BCR0.94161645
76CSF1R0.93083313
77PAK40.92302603
78TEC0.91524732
79GRK70.91010186
80TGFBR20.89863441
81CHEK10.89459375
82CHEK20.86863788
83IRAK20.85050634
84KSR10.84911911
85PINK10.83414047
86SIK30.82896043
87MKNK10.81366386
88TBK10.80440481
89MST40.79411815
90GRK60.79250755
91ADRBK10.78309979
92MAPKAPK30.78228290
93CCNB10.75954752
94STK390.75740539
95AURKA0.74791827
96BRSK10.74785949
97TESK10.73466867
98SGK20.70903667
99TRPM70.70265857
100BLK0.70170694
101INSRR0.70045191
102IRAK40.69490583
103CLK10.68399721
104ERN10.67626412
105CDK60.66283377
106NLK0.66002569
107FER0.65776446
108MATK0.65622864
109CASK0.65523418
110CAMKK20.65237830
111OXSR10.64819656
112PRKCQ0.63723215
113TXK0.62967824
114MAP3K30.62382467
115PDK30.62284967
116PDK40.62284967
117IKBKB0.62260697
118ZAK0.61433095
119STK30.61363209
120PRKCE0.60593042
121CDK20.60025288
122MAP3K110.60010775
123ATM0.59991142
124PLK30.57746915
125ALK0.55845683
126PIK3CA0.55399867
127DYRK1A0.54445547
128CDK90.53992814
129RPS6KA50.53787411
130BCKDK0.52969306
131PRKCG0.52316228
132MELK0.51262472
133MAP2K60.50045556
134CSNK2A20.49987287
135TAOK20.47265081
136PTK2B0.46724656
137CSNK1G20.45117817
138PRKCZ0.44800869
139CHUK0.44742584
140LCK0.44430564
141WNK10.44303542
142PRKCI0.43289301
143CSNK1D0.43139378
144EPHA30.42975790
145CSNK2A10.42681181
146STK110.42259582
147MKNK20.42121124
148STK240.42049188
149EIF2AK20.42003745
150NEK90.41590702
151CDK80.41584103
152MTOR0.41110868
153MAP2K70.40685054
154PAK10.40162915
155MAPK70.39757697
156PLK20.39733883
157BMPR20.39360824
158JAK20.39240101
159TNK20.38951965
160ITK0.38837326
161LYN0.38483512
162ERBB30.38054526
163SIK20.37593312
164CSNK1A1L0.36030566
165HCK0.35702843
166CSNK1G10.35152745
167LATS10.35024947

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.78213357
2Mismatch repair_Homo sapiens_hsa034303.95600387
3Ribosome_Homo sapiens_hsa030103.32537357
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.93027757
5Base excision repair_Homo sapiens_hsa034102.87018424
6Spliceosome_Homo sapiens_hsa030402.73592831
7RNA transport_Homo sapiens_hsa030132.63368218
8RNA polymerase_Homo sapiens_hsa030202.62990600
9Phototransduction_Homo sapiens_hsa047442.51180616
10Homologous recombination_Homo sapiens_hsa034402.50885519
11Nucleotide excision repair_Homo sapiens_hsa034202.45461407
12Dorso-ventral axis formation_Homo sapiens_hsa043202.40827237
13One carbon pool by folate_Homo sapiens_hsa006702.40709455
14Pyrimidine metabolism_Homo sapiens_hsa002402.30850463
15Cell cycle_Homo sapiens_hsa041102.25818160
16Proteasome_Homo sapiens_hsa030502.23543431
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.23500936
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.92704646
19Non-homologous end-joining_Homo sapiens_hsa034501.87158418
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.80619424
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.75846255
22Fanconi anemia pathway_Homo sapiens_hsa034601.73446854
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.68229880
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.64805364
25Linoleic acid metabolism_Homo sapiens_hsa005911.58899146
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.58477437
27p53 signaling pathway_Homo sapiens_hsa041151.55650879
28RNA degradation_Homo sapiens_hsa030181.52910182
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.52863253
30Folate biosynthesis_Homo sapiens_hsa007901.51283987
31Nitrogen metabolism_Homo sapiens_hsa009101.47903778
32Regulation of autophagy_Homo sapiens_hsa041401.45217857
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.44387364
34Basal transcription factors_Homo sapiens_hsa030221.40517743
35Caffeine metabolism_Homo sapiens_hsa002321.40414990
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.38155881
37Antigen processing and presentation_Homo sapiens_hsa046121.36289585
38Primary immunodeficiency_Homo sapiens_hsa053401.34826187
39Systemic lupus erythematosus_Homo sapiens_hsa053221.34640615
40Butanoate metabolism_Homo sapiens_hsa006501.33645182
41Epstein-Barr virus infection_Homo sapiens_hsa051691.31305166
42Circadian rhythm_Homo sapiens_hsa047101.27015987
43mRNA surveillance pathway_Homo sapiens_hsa030151.26372744
44Selenocompound metabolism_Homo sapiens_hsa004501.26234698
45Herpes simplex infection_Homo sapiens_hsa051681.25519123
46Ether lipid metabolism_Homo sapiens_hsa005651.24088775
47Viral carcinogenesis_Homo sapiens_hsa052031.18847007
48Tryptophan metabolism_Homo sapiens_hsa003801.18632282
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.17836776
50Pentose phosphate pathway_Homo sapiens_hsa000301.13460102
51ABC transporters_Homo sapiens_hsa020101.10088251
52Sulfur relay system_Homo sapiens_hsa041221.09795042
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.06452745
54Purine metabolism_Homo sapiens_hsa002301.05148586
55Measles_Homo sapiens_hsa051621.04131301
56FoxO signaling pathway_Homo sapiens_hsa040680.99573280
57Acute myeloid leukemia_Homo sapiens_hsa052210.98672603
58Drug metabolism - other enzymes_Homo sapiens_hsa009830.97123681
59Olfactory transduction_Homo sapiens_hsa047400.95133375
60Legionellosis_Homo sapiens_hsa051340.93678758
61B cell receptor signaling pathway_Homo sapiens_hsa046620.92061800
62Nicotine addiction_Homo sapiens_hsa050330.91235024
63Protein export_Homo sapiens_hsa030600.87448299
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86425605
65Small cell lung cancer_Homo sapiens_hsa052220.86238895
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.85967924
67Collecting duct acid secretion_Homo sapiens_hsa049660.85481070
68TGF-beta signaling pathway_Homo sapiens_hsa043500.84886605
69HTLV-I infection_Homo sapiens_hsa051660.83078245
70NF-kappa B signaling pathway_Homo sapiens_hsa040640.82678875
71Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81891245
72N-Glycan biosynthesis_Homo sapiens_hsa005100.80209455
73Taste transduction_Homo sapiens_hsa047420.78469669
74Biosynthesis of amino acids_Homo sapiens_hsa012300.78001874
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.76760740
76Thyroid cancer_Homo sapiens_hsa052160.74633587
77Apoptosis_Homo sapiens_hsa042100.74438699
78Chronic myeloid leukemia_Homo sapiens_hsa052200.74205763
79Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73571814
80Ovarian steroidogenesis_Homo sapiens_hsa049130.70748444
81Hepatitis B_Homo sapiens_hsa051610.70358471
82Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69312988
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68132862
84Leishmaniasis_Homo sapiens_hsa051400.67873175
85Hematopoietic cell lineage_Homo sapiens_hsa046400.66657036
86RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.64413197
87Rheumatoid arthritis_Homo sapiens_hsa053230.63787922
88Vitamin B6 metabolism_Homo sapiens_hsa007500.62930976
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62585124
90Hedgehog signaling pathway_Homo sapiens_hsa043400.62171348
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62126026
92Cyanoamino acid metabolism_Homo sapiens_hsa004600.62105913
93Prolactin signaling pathway_Homo sapiens_hsa049170.60831993
94Influenza A_Homo sapiens_hsa051640.58701544
95Jak-STAT signaling pathway_Homo sapiens_hsa046300.58697595
96Propanoate metabolism_Homo sapiens_hsa006400.58679159
97Sphingolipid metabolism_Homo sapiens_hsa006000.58262006
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57779305
99Shigellosis_Homo sapiens_hsa051310.57141462
100Type II diabetes mellitus_Homo sapiens_hsa049300.56875595
101Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56868152
102T cell receptor signaling pathway_Homo sapiens_hsa046600.54882471
103Colorectal cancer_Homo sapiens_hsa052100.54792041
104Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.54765808
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.53466671
106Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51071484
107Morphine addiction_Homo sapiens_hsa050320.50598726
108Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.49931066
109African trypanosomiasis_Homo sapiens_hsa051430.48879459
110Osteoclast differentiation_Homo sapiens_hsa043800.48289740
111Chemokine signaling pathway_Homo sapiens_hsa040620.47900502
112Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.47586951
113Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47130591
114Toxoplasmosis_Homo sapiens_hsa051450.46957465
115Primary bile acid biosynthesis_Homo sapiens_hsa001200.46915754
116Intestinal immune network for IgA production_Homo sapiens_hsa046720.46203113
117Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.45694104
118Type I diabetes mellitus_Homo sapiens_hsa049400.45527423
119Lysine degradation_Homo sapiens_hsa003100.45112689
120Serotonergic synapse_Homo sapiens_hsa047260.45094686
121MAPK signaling pathway_Homo sapiens_hsa040100.44411199
122Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44307483
123Graft-versus-host disease_Homo sapiens_hsa053320.42105308
124Oocyte meiosis_Homo sapiens_hsa041140.41991811
125Non-small cell lung cancer_Homo sapiens_hsa052230.41507225
126mTOR signaling pathway_Homo sapiens_hsa041500.40870749
127Melanoma_Homo sapiens_hsa052180.40519223
128Pancreatic cancer_Homo sapiens_hsa052120.39772995
129Glutathione metabolism_Homo sapiens_hsa004800.39354293
130Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38868873
131Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38787055
132MicroRNAs in cancer_Homo sapiens_hsa052060.37875979
133Steroid hormone biosynthesis_Homo sapiens_hsa001400.37459518
134Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37168940
135Glycerolipid metabolism_Homo sapiens_hsa005610.36539043
136Tuberculosis_Homo sapiens_hsa051520.36533310
137Carbon metabolism_Homo sapiens_hsa012000.35801389
138Arachidonic acid metabolism_Homo sapiens_hsa005900.35667177
139Toll-like receptor signaling pathway_Homo sapiens_hsa046200.35470842
140Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.35454477
141Long-term depression_Homo sapiens_hsa047300.35271067
142Insulin resistance_Homo sapiens_hsa049310.34626066
143NOD-like receptor signaling pathway_Homo sapiens_hsa046210.33554340
144Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33082298
145HIF-1 signaling pathway_Homo sapiens_hsa040660.33061678
146TNF signaling pathway_Homo sapiens_hsa046680.31753884
147Glycosaminoglycan degradation_Homo sapiens_hsa005310.30263717
148Leukocyte transendothelial migration_Homo sapiens_hsa046700.30252858
149Alcoholism_Homo sapiens_hsa050340.28382232
150Galactose metabolism_Homo sapiens_hsa000520.27905201
151Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.27015437
152Fructose and mannose metabolism_Homo sapiens_hsa000510.25239713
153Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.24811219
154Bladder cancer_Homo sapiens_hsa052190.23038275
155Endometrial cancer_Homo sapiens_hsa052130.21303459
156Hepatitis C_Homo sapiens_hsa051600.20446492
157Prostate cancer_Homo sapiens_hsa052150.19897385
158Allograft rejection_Homo sapiens_hsa053300.19762348

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