SNRK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: SNRK is a member of the sucrose nonfermenting (SNF)-related kinase family of serine/threonine kinases (Kertesz et al., 2002 [PubMed 12234663]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)5.79301694
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.79301694
3positive regulation of gamma-delta T cell activation (GO:0046645)5.75285282
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.19406641
5regulation of B cell receptor signaling pathway (GO:0050855)4.83867610
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.60651037
7cellular extravasation (GO:0045123)4.59705731
8presynaptic membrane assembly (GO:0097105)4.41466451
9regulation of gamma-delta T cell differentiation (GO:0045586)4.36941251
10regulation of gamma-delta T cell activation (GO:0046643)4.32761802
11response to interleukin-15 (GO:0070672)4.29769524
12antigen processing and presentation of endogenous antigen (GO:0019883)4.29192687
13cellular response to interleukin-15 (GO:0071350)4.19578314
14antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.18306233
15neurotransmitter-gated ion channel clustering (GO:0072578)4.17694679
16positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.15674647
17modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.12958162
18modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.12958162
19positive regulation by organism of defense response of other organism involved in symbiotic interact4.12958162
20modulation by symbiont of host immune response (GO:0052553)4.12958162
21positive regulation by symbiont of host defense response (GO:0052509)4.12958162
22modulation by symbiont of host defense response (GO:0052031)4.12958162
23negative T cell selection (GO:0043383)4.00134796
24positive T cell selection (GO:0043368)3.99370584
25positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.98311037
26negative thymic T cell selection (GO:0045060)3.92597806
27postsynaptic membrane organization (GO:0001941)3.79750288
28presynaptic membrane organization (GO:0097090)3.79352404
29activated T cell proliferation (GO:0050798)3.75492005
30detection of molecule of bacterial origin (GO:0032490)3.74454485
31detection of other organism (GO:0098543)3.74222903
32neuron cell-cell adhesion (GO:0007158)3.73601823
33negative regulation of lymphocyte mediated immunity (GO:0002707)3.71072391
34positive thymic T cell selection (GO:0045059)3.62211907
35tolerance induction (GO:0002507)3.56425908
36positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.54606930
37macrophage activation involved in immune response (GO:0002281)3.53436618
38negative regulation of T cell mediated immunity (GO:0002710)3.51472277
39response to muramyl dipeptide (GO:0032495)3.46374564
40phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.42314944
41B cell receptor signaling pathway (GO:0050853)3.42073296
42leukocyte aggregation (GO:0070486)3.39548212
43detection of external biotic stimulus (GO:0098581)3.38594901
44T cell selection (GO:0045058)3.35471626
45protein localization to synapse (GO:0035418)3.31949403
46detection of bacterium (GO:0016045)3.29252338
47microglial cell activation (GO:0001774)3.24963242
48regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.24804390
49macrophage activation (GO:0042116)3.18296661
50negative regulation of interleukin-12 production (GO:0032695)3.17911474
51regulation of interferon-beta biosynthetic process (GO:0045357)3.16487618
52negative regulation of leukocyte mediated immunity (GO:0002704)3.15944374
53neuronal action potential propagation (GO:0019227)3.10944091
54Golgi to endosome transport (GO:0006895)3.10356144
55synaptic vesicle maturation (GO:0016188)3.10208719
56regulation of synaptic vesicle exocytosis (GO:2000300)3.08299163
57positive regulation of tolerance induction (GO:0002645)3.07041658
58regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.06373359
59positive regulation of dendritic spine development (GO:0060999)3.05782472
60vocalization behavior (GO:0071625)3.03286763
61membrane assembly (GO:0071709)3.01418313
62interferon-gamma production (GO:0032609)3.01010794
63T cell migration (GO:0072678)3.00665692
64thymic T cell selection (GO:0045061)3.00658745
65regulation of tolerance induction (GO:0002643)2.99646830
66positive regulation of granulocyte differentiation (GO:0030854)2.96641837
67regulation of T cell tolerance induction (GO:0002664)2.96199364
68positive regulation of synaptic transmission, GABAergic (GO:0032230)2.95510526
69regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.95122553
70positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.94905677
71positive regulation of B cell differentiation (GO:0045579)2.94329075
72detection of biotic stimulus (GO:0009595)2.94132194
73histone H3-K36 demethylation (GO:0070544)2.93745395
74neutrophil mediated immunity (GO:0002446)2.93742938
75negative regulation of erythrocyte differentiation (GO:0045647)2.93255727
76response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.91811232
77response to host immune response (GO:0052572)2.91811232
78regulation of B cell differentiation (GO:0045577)2.88881940
79negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.88378999
80negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.84811147
81regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.84347528
82cellular potassium ion homeostasis (GO:0030007)2.84188174
83adult heart development (GO:0007512)2.82889561
84neutrophil activation involved in immune response (GO:0002283)2.82798913
85layer formation in cerebral cortex (GO:0021819)2.82635092
86myeloid leukocyte mediated immunity (GO:0002444)2.80782502
87regulation of regulatory T cell differentiation (GO:0045589)2.80040463
88positive regulation of membrane potential (GO:0045838)2.79505176
89neutrophil activation (GO:0042119)2.78786653
90positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.77901998
91gamma-aminobutyric acid transport (GO:0015812)2.77784389
92positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.77180752
93response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.75228289
94response to host (GO:0075136)2.75228289
95response to host defenses (GO:0052200)2.75228289
96regulation of alpha-beta T cell proliferation (GO:0046640)2.73409275
97negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.73005903
98negative regulation of T-helper cell differentiation (GO:0045623)2.73005903
99response to peptidoglycan (GO:0032494)2.70595362
100cellular response to ethanol (GO:0071361)2.69276168
101regulation of glutamate receptor signaling pathway (GO:1900449)2.66850675
102positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.66466851
103negative regulation of inclusion body assembly (GO:0090084)2.65992910
104myeloid cell activation involved in immune response (GO:0002275)2.65079422
105antigen receptor-mediated signaling pathway (GO:0050851)2.62310384
106negative regulation of adaptive immune response (GO:0002820)2.61471193
107germinal center formation (GO:0002467)2.61221889
108positive regulation of neurotransmitter secretion (GO:0001956)2.60399226
109potassium ion import (GO:0010107)2.60252963
110regulation of short-term neuronal synaptic plasticity (GO:0048172)2.59910746
111regulation of histone H3-K27 methylation (GO:0061085)2.58375874
112cerebellar Purkinje cell differentiation (GO:0021702)2.57434483
113regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.56751666
114mating behavior (GO:0007617)2.56544209
115regulation of interleukin-12 biosynthetic process (GO:0045075)2.56344485
116regulation of synaptic vesicle transport (GO:1902803)2.55947426
117locomotory exploration behavior (GO:0035641)2.55074696
118positive regulation of mast cell activation (GO:0033005)2.55000997
119regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.54530673
120antigen processing and presentation via MHC class Ib (GO:0002475)2.54373241
121T cell receptor signaling pathway (GO:0050852)2.53227655
122ionotropic glutamate receptor signaling pathway (GO:0035235)2.52855419
123regulation of mast cell degranulation (GO:0043304)2.51473127
124regulation of mast cell activation (GO:0033003)2.50850660
125cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.50532047
126dendritic cell migration (GO:0036336)2.50165731
127regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.50134485
128regulation of natural killer cell mediated immunity (GO:0002715)2.50134485
129regulation of excitatory postsynaptic membrane potential (GO:0060079)2.49337342
130negative regulation of cAMP-mediated signaling (GO:0043951)2.48729143
131synaptic vesicle exocytosis (GO:0016079)2.48507085
132glutamate receptor signaling pathway (GO:0007215)2.48135348
133growth hormone receptor signaling pathway (GO:0060396)2.47945722
134regulation of dendritic spine development (GO:0060998)2.47921874
135activation of protein kinase A activity (GO:0034199)2.45944107
136production of molecular mediator involved in inflammatory response (GO:0002532)2.45557712
137negative regulation of B cell mediated immunity (GO:0002713)2.45380659
138negative regulation of immunoglobulin mediated immune response (GO:0002890)2.45380659
139mast cell activation (GO:0045576)2.44790950
140granulocyte activation (GO:0036230)2.43996496
141negative regulation of glycoprotein biosynthetic process (GO:0010561)2.43446843
142regulation of T cell mediated cytotoxicity (GO:0001914)2.42924362
143regulation of voltage-gated calcium channel activity (GO:1901385)2.42158228
144positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.41351529
145cerebellar granule cell differentiation (GO:0021707)2.39750436
146positive regulation of synapse assembly (GO:0051965)2.39515830
147membrane hyperpolarization (GO:0060081)2.39391741
148regulation of postsynaptic membrane potential (GO:0060078)2.38896800
149regulation of cell communication by electrical coupling (GO:0010649)2.38850042
150positive regulation of neurotransmitter transport (GO:0051590)2.37999791
151positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.37703435
152gamma-aminobutyric acid signaling pathway (GO:0007214)2.37211875
153response to pheromone (GO:0019236)2.37200185
154regulation of respiratory system process (GO:0044065)2.37100045
155sodium ion export (GO:0071436)2.36954381
156neurotransmitter secretion (GO:0007269)2.34904716
157regulation of synapse structural plasticity (GO:0051823)2.34084013
158negative regulation of synaptic transmission, GABAergic (GO:0032229)2.33134306
159regulation of cardiac muscle cell contraction (GO:0086004)2.32571135
160mechanosensory behavior (GO:0007638)2.31346512
161regulation of sequestering of triglyceride (GO:0010889)2.28097357
162membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.27374279
163synapse assembly (GO:0007416)2.26797304
164G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.26505001
165lymph vessel development (GO:0001945)2.24569902
166negative regulation of cytosolic calcium ion concentration (GO:0051481)2.24346655
167acylglycerol catabolic process (GO:0046464)2.24199123
168neutral lipid catabolic process (GO:0046461)2.24199123
169glutamate secretion (GO:0014047)2.22471205
170regulation of respiratory gaseous exchange (GO:0043576)2.21927407
171regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.21880162
172triglyceride catabolic process (GO:0019433)2.21867115
173negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.20529444
174regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.20152213
175endothelium development (GO:0003158)2.17626506
176heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.16458007
177cellular response to epinephrine stimulus (GO:0071872)2.15958782
178positive regulation of fatty acid oxidation (GO:0046321)2.15799702
179neuron recognition (GO:0008038)2.15470998
180membrane depolarization (GO:0051899)2.15064685
181transmission of nerve impulse (GO:0019226)2.14452428
182potassium ion homeostasis (GO:0055075)2.13180114
183long-term memory (GO:0007616)2.12334491
184neuron-neuron synaptic transmission (GO:0007270)2.11715887
185dendrite morphogenesis (GO:0048813)2.11490743
186cell differentiation in hindbrain (GO:0021533)2.10695406
187positive regulation of potassium ion transmembrane transport (GO:1901381)2.10139009
188neurotransmitter transport (GO:0006836)2.09862709
189cell communication by electrical coupling (GO:0010644)2.09821215
190positive regulation of fatty acid beta-oxidation (GO:0032000)2.09631355
191peptidyl-tyrosine autophosphorylation (GO:0038083)2.09100251
192fatty acid transmembrane transport (GO:1902001)2.09029360
193regulation of dendritic spine morphogenesis (GO:0061001)2.08907079
194regulation of actin filament-based movement (GO:1903115)2.07706577
195regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.07163507
196protein localization to endosome (GO:0036010)2.06966252
197dendritic spine morphogenesis (GO:0060997)2.06543956
198synaptic transmission, glutamatergic (GO:0035249)2.06086395
199neuromuscular process controlling posture (GO:0050884)2.05160250

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.63553994
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.80988642
3EZH2_22144423_ChIP-Seq_EOC_Human3.67464726
4BP1_19119308_ChIP-ChIP_Hs578T_Human2.94177195
5STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.85585437
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.65811183
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.59182486
8FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.58087132
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.52539983
10GBX2_23144817_ChIP-Seq_PC3_Human2.50872348
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.49054883
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.48218150
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.45534032
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.42723194
15IRF8_27001747_Chip-Seq_BMDM_Mouse2.37622215
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.36909378
17EZH2_18974828_ChIP-Seq_MESCs_Mouse2.36909378
18TAF15_26573619_Chip-Seq_HEK293_Human2.29953594
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.27752511
20BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.27018318
21IRF8_21731497_ChIP-ChIP_J774_Mouse2.24167750
22MTF2_20144788_ChIP-Seq_MESCs_Mouse2.22164259
23MYB_21317192_ChIP-Seq_ERMYB_Mouse2.20793952
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.19816855
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.16761785
26SCL_19346495_ChIP-Seq_HPC-7_Human2.16652956
27EED_16625203_ChIP-ChIP_MESCs_Mouse2.14222912
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.08375106
29JARID2_20075857_ChIP-Seq_MESCs_Mouse2.07855228
30* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.06862080
31* MYB_26560356_Chip-Seq_TH2_Human2.05101881
32NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.97920925
33Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.96614285
34* VDR_24787735_ChIP-Seq_THP-1_Human1.96597490
35EZH2_27304074_Chip-Seq_ESCs_Mouse1.95465003
36DROSHA_22980978_ChIP-Seq_HELA_Human1.92825492
37EZH2_27294783_Chip-Seq_ESCs_Mouse1.87672250
38SUZ12_27294783_Chip-Seq_ESCs_Mouse1.86105359
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.81077213
40IKZF1_21737484_ChIP-ChIP_HCT116_Human1.77616798
41SPI1_23127762_ChIP-Seq_K562_Human1.72636625
42MYB_26560356_Chip-Seq_TH1_Human1.69587214
43GATA3_27048872_Chip-Seq_THYMUS_Human1.69530589
44IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.68824962
45CDX2_19796622_ChIP-Seq_MESCs_Mouse1.66864846
46NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.65267951
47RNF2_27304074_Chip-Seq_ESCs_Mouse1.62910163
48GATA1_22025678_ChIP-Seq_K562_Human1.59042764
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56143251
50STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.53855544
51AR_21572438_ChIP-Seq_LNCaP_Human1.53155865
52PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.50666065
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.45272768
54* REST_21632747_ChIP-Seq_MESCs_Mouse1.45189101
55SMAD_19615063_ChIP-ChIP_OVARY_Human1.42088377
56SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.38627034
57MAF_26560356_Chip-Seq_TH1_Human1.37767590
58TCF7_22412390_ChIP-Seq_EML_Mouse1.37032122
59STAT4_19710469_ChIP-ChIP_TH1__Mouse1.36558363
60SPI1_23547873_ChIP-Seq_NB4_Human1.36130723
61VDR_24763502_ChIP-Seq_THP-1_Human1.35942188
62RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.34758495
63RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32207163
64CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31215451
65E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.30324141
66GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30148870
67SMAD4_21799915_ChIP-Seq_A2780_Human1.29773380
68EP300_21415370_ChIP-Seq_HL-1_Mouse1.29711813
69GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.29701869
70RUNX1_22412390_ChIP-Seq_EML_Mouse1.28984461
71GATA3_26560356_Chip-Seq_TH2_Human1.27959638
72BCAT_22108803_ChIP-Seq_LS180_Human1.27472249
73PIAS1_25552417_ChIP-Seq_VCAP_Human1.27391544
74RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.27152916
75ZNF217_24962896_ChIP-Seq_MCF-7_Human1.26349357
76BRD4_27068464_Chip-Seq_AML-cells_Mouse1.26214151
77ZFP57_27257070_Chip-Seq_ESCs_Mouse1.24789646
78ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.22911118
79CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22798276
80UTX_26944678_Chip-Seq_JUKART_Human1.22519674
81EGR1_19374776_ChIP-ChIP_THP-1_Human1.22235304
82KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.20826192
83ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.20167829
84* RXR_22158963_ChIP-Seq_LIVER_Mouse1.16952731
85* REST_18959480_ChIP-ChIP_MESCs_Mouse1.16412682
86GATA1_19941827_ChIP-Seq_MEL_Mouse1.15180544
87* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.14978067
88ZNF274_21170338_ChIP-Seq_K562_Hela1.14646822
89PU_27001747_Chip-Seq_BMDM_Mouse1.14484135
90KDM2B_26808549_Chip-Seq_DND41_Human1.13322580
91* LXR_22158963_ChIP-Seq_LIVER_Mouse1.13048839
92SMAD3_21741376_ChIP-Seq_EPCs_Human1.11170030
93GATA1_19941826_ChIP-Seq_K562_Human1.10979482
94* P300_19829295_ChIP-Seq_ESCs_Human1.10871159
95SMAD3_21741376_ChIP-Seq_HESCs_Human1.10456024
96RARB_27405468_Chip-Seq_BRAIN_Mouse1.10152449
97SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09072192
98* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.08345553
99RING1B_27294783_Chip-Seq_ESCs_Mouse1.07938816
100AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07889176
101WT1_19549856_ChIP-ChIP_CCG9911_Human1.07564314
102LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.07438325
103KDM2B_26808549_Chip-Seq_K562_Human1.07045726
104SMAD4_21741376_ChIP-Seq_HESCs_Human1.06542858
105BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05349986
106SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05111738
107* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.03152359
108TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03009356
109AHR_22903824_ChIP-Seq_MCF-7_Human1.02579236
110* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02331952
111NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02095662
112GATA2_19941826_ChIP-Seq_K562_Human1.02012503
113KDM2B_26808549_Chip-Seq_JURKAT_Human1.01065732
114TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01041385
115ESR1_20079471_ChIP-ChIP_T-47D_Human1.01030321
116NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.00496884
117AR_25329375_ChIP-Seq_VCAP_Human1.00407591
118FOXO3_23340844_ChIP-Seq_DLD1_Human1.00187380
119IGF1R_20145208_ChIP-Seq_DFB_Human1.00012829
120* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.99451169
121MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.99193445
122CBX2_27304074_Chip-Seq_ESCs_Mouse0.98650406
123WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98593969
124FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.96576635
125GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96128653
126MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.95899685
127FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.95860251
128ARNT_22903824_ChIP-Seq_MCF-7_Human0.95847136
129* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95830687
130* STAT3_23295773_ChIP-Seq_U87_Human0.95606804
131SOX2_21211035_ChIP-Seq_LN229_Gbm0.94864970
132RXR_22108803_ChIP-Seq_LS180_Human0.94809100
133LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.93250460
134* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92553678
135KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.92273726
136GATA1_19941827_ChIP-Seq_MEL86_Mouse0.92148231
137SMRT_27268052_Chip-Seq_Bcells_Human0.91688606
138PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91486515
139NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.89741414
140SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.89242851
141KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.89022006
142TP53_16413492_ChIP-PET_HCT116_Human0.88730686
143DNAJC2_21179169_ChIP-ChIP_NT2_Human0.88418694
144VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.88191388
145RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.88087088
146KDM2B_26808549_Chip-Seq_SUP-B15_Human0.87733858
147GATA2_21666600_ChIP-Seq_HMVEC_Human0.87684525
148NRF2_20460467_ChIP-Seq_MEFs_Mouse0.87096559
149NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.87096559
150ERG_21242973_ChIP-ChIP_JURKAT_Human0.86840176
151BMI1_23680149_ChIP-Seq_NPCS_Mouse0.86576623
152FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.86220112
153ER_23166858_ChIP-Seq_MCF-7_Human0.86011052
154* PPARA_22158963_ChIP-Seq_LIVER_Mouse0.85556635
155CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.85332997
156RUNX2_22187159_ChIP-Seq_PCA_Human0.84911454
157* AR_19668381_ChIP-Seq_PC3_Human0.84367736
158ESR2_21235772_ChIP-Seq_MCF-7_Human0.83084315
159WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.83029087
160RUNX_20019798_ChIP-Seq_JUKART_Human0.82910499
161CTNNB1_20460455_ChIP-Seq_HCT116_Human0.82630240
162THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.82388053
163PRDM14_20953172_ChIP-Seq_ESCs_Human0.82281193
164MAF_26560356_Chip-Seq_TH2_Human0.82052829
165VDR_21846776_ChIP-Seq_THP-1_Human0.81258653
166FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.80756640
167EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.80626553
168GATA2_22383799_ChIP-Seq_G1ME_Mouse0.79787751
169ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.75804931
170CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.75497653
171PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.74442333
172TP63_23658742_ChIP-Seq_EP156T_Human0.74344910
173FLI1_21867929_ChIP-Seq_TH2_Mouse0.72417521

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.08046585
2MP0003303_peritoneal_inflammation3.53905900
3MP0003763_abnormal_thymus_physiology3.32430946
4MP0003436_decreased_susceptibility_to3.16418281
5MP0001835_abnormal_antigen_presentation2.92216776
6MP0000465_gastrointestinal_hemorrhage2.89448187
7MP0004859_abnormal_synaptic_plasticity2.78741452
8MP0002837_dystrophic_cardiac_calcinosis2.66296218
9MP0003300_gastrointestinal_ulcer2.63407405
10MP0001800_abnormal_humoral_immune2.59511224
11MP0003635_abnormal_synaptic_transmissio2.49685546
12MP0005671_abnormal_response_to2.43759078
13MP0009046_muscle_twitch2.36550690
14MP0002419_abnormal_innate_immunity2.33464251
15MP0005000_abnormal_immune_tolerance2.31994269
16MP0006276_abnormal_autonomic_nervous2.26667260
17MP0002723_abnormal_immune_serum2.20508416
18MP0002420_abnormal_adaptive_immunity2.18575716
19MP0005025_abnormal_response_to2.18546364
20MP0000569_abnormal_digit_pigmentation2.17884223
21MP0001819_abnormal_immune_cell2.14870462
22MP0009745_abnormal_behavioral_response2.12994776
23MP0004130_abnormal_muscle_cell2.08444786
24MP0002166_altered_tumor_susceptibility2.03291880
25MP0000685_abnormal_immune_system2.01117393
26MP0002452_abnormal_antigen_presenting1.99503849
27MP0002064_seizures1.99489350
28MP0009379_abnormal_foot_pigmentation1.98170532
29MP0001790_abnormal_immune_system1.96518090
30MP0005387_immune_system_phenotype1.96518090
31MP0009785_altered_susceptibility_to1.95301548
32MP0004215_abnormal_myocardial_fiber1.92972018
33MP0008260_abnormal_autophagy1.89470843
34MP0005551_abnormal_eye_electrophysiolog1.88440152
35MP0005670_abnormal_white_adipose1.86867879
36MP0002822_catalepsy1.85492209
37MP0010368_abnormal_lymphatic_system1.85096998
38MP0001968_abnormal_touch/_nociception1.84387726
39MP0002272_abnormal_nervous_system1.84277420
40MP0001501_abnormal_sleep_pattern1.83362282
41MP0008569_lethality_at_weaning1.83352609
42MP0000751_myopathy1.82552278
43MP0004272_abnormal_basement_membrane1.78803540
44MP0002398_abnormal_bone_marrow1.76869533
45MP0002405_respiratory_system_inflammati1.76610041
46MP0004270_analgesia1.72317970
47MP0002139_abnormal_hepatobiliary_system1.71211147
48MP0006082_CNS_inflammation1.70323141
49MP0001533_abnormal_skeleton_physiology1.68843112
50MP0000013_abnormal_adipose_tissue1.68590021
51MP0000716_abnormal_immune_system1.67802710
52MP0001851_eye_inflammation1.67315146
53MP0005167_abnormal_blood-brain_barrier1.67077601
54MP0000703_abnormal_thymus_morphology1.66878585
55MP0010155_abnormal_intestine_physiology1.64112322
56MP0002063_abnormal_learning/memory/cond1.61467171
57MP0001879_abnormal_lymphatic_vessel1.60789977
58MP0001486_abnormal_startle_reflex1.59433766
59MP0004947_skin_inflammation1.59227638
60MP0005464_abnormal_platelet_physiology1.59209413
61MP0002067_abnormal_sensory_capabilities1.56306820
62MP0005423_abnormal_somatic_nervous1.55208184
63MP0004883_abnormal_blood_vessel1.54762428
64MP0005360_urolithiasis1.53612128
65MP0001440_abnormal_grooming_behavior1.52707399
66MP0002572_abnormal_emotion/affect_behav1.50313781
67MP0003866_abnormal_defecation1.48089201
68MP0005535_abnormal_body_temperature1.47836355
69MP0002722_abnormal_immune_system1.46180341
70MP0002148_abnormal_hypersensitivity_rea1.45238085
71MP0002933_joint_inflammation1.45191989
72MP0004145_abnormal_muscle_electrophysio1.44346783
73MP0002009_preneoplasia1.42583441
74MP0000689_abnormal_spleen_morphology1.42126856
75MP0003868_abnormal_feces_composition1.41812410
76MP0006054_spinal_hemorrhage1.41472857
77MP0005409_darkened_coat_color1.40764219
78MP0003656_abnormal_erythrocyte_physiolo1.40482935
79MP0003191_abnormal_cellular_cholesterol1.40468298
80MP0002138_abnormal_hepatobiliary_system1.40361719
81MP0004484_altered_response_of1.39386286
82MP0002734_abnormal_mechanical_nocicepti1.37980499
83MP0003172_abnormal_lysosome_physiology1.35640218
84MP0002638_abnormal_pupillary_reflex1.35526092
85MP0005666_abnormal_adipose_tissue1.35171613
86MP0002971_abnormal_brown_adipose1.34360274
87MP0010329_abnormal_lipoprotein_level1.33732633
88MP0001845_abnormal_inflammatory_respons1.32914265
89MP0005075_abnormal_melanosome_morpholog1.31987595
90MP0005310_abnormal_salivary_gland1.31325871
91MP0003183_abnormal_peptide_metabolism1.29643598
92MP0009764_decreased_sensitivity_to1.27326559
93MP0005451_abnormal_body_composition1.26473304
94MP0002429_abnormal_blood_cell1.24646745
95MP0003646_muscle_fatigue1.24549407
96MP0004085_abnormal_heartbeat1.24535524
97MP0002184_abnormal_innervation1.23829992
98MP0001984_abnormal_olfaction1.22441134
99MP0002006_tumorigenesis1.21545073
100MP0002998_abnormal_bone_remodeling1.20191223
101MP0005386_behavior/neurological_phenoty1.19188844
102MP0004924_abnormal_behavior1.19188844
103MP0003633_abnormal_nervous_system1.18339855
104MP0002557_abnormal_social/conspecific_i1.17715177
105MP0005375_adipose_tissue_phenotype1.17632794
106MP0004036_abnormal_muscle_relaxation1.17389220
107MP0001970_abnormal_pain_threshold1.16733353
108MP0002909_abnormal_adrenal_gland1.15681787
109MP0008875_abnormal_xenobiotic_pharmacok1.14503132
110MP0002733_abnormal_thermal_nociception1.14357400
111MP0001661_extended_life_span1.14046660
112MP0009333_abnormal_splenocyte_physiolog1.12009534
113MP0002736_abnormal_nociception_after1.11553249
114MP0003724_increased_susceptibility_to1.11327671
115MP0002277_abnormal_respiratory_mucosa1.10284938
116MP0005164_abnormal_response_to1.09977785
117MP0003011_delayed_dark_adaptation1.09422835
118MP0002332_abnormal_exercise_endurance1.08400304
119MP0002132_abnormal_respiratory_system1.08271532
120MP0005085_abnormal_gallbladder_physiolo1.08135546
121MP0004185_abnormal_adipocyte_glucose1.07937977
122MP0000015_abnormal_ear_pigmentation1.07916596
123MP0001502_abnormal_circadian_rhythm1.07375432
124MP0002396_abnormal_hematopoietic_system1.06183652
125MP0006072_abnormal_retinal_apoptosis1.06029857
126MP0003787_abnormal_imprinting1.04093790
127MP0006138_congestive_heart_failure1.02627549
128MP0001188_hyperpigmentation1.01904920
129MP0000249_abnormal_blood_vessel1.01237035
130MP0004381_abnormal_hair_follicle1.01114231
131MP0003329_amyloid_beta_deposits1.00689711
132MP0005595_abnormal_vascular_smooth1.00266752
133MP0005623_abnormal_meninges_morphology0.99571870
134MP0005330_cardiomyopathy0.98734649
135MP0004084_abnormal_cardiac_muscle0.98675959
136MP0005620_abnormal_muscle_contractility0.97728066
137MP0000778_abnormal_nervous_system0.97405652
138MP0009278_abnormal_bone_marrow0.96517709
139MP0008874_decreased_physiological_sensi0.94683328
140MP0005365_abnormal_bile_salt0.94260046
141MP0003091_abnormal_cell_migration0.93319107
142MP0000230_abnormal_systemic_arterial0.92017944
143MP0003221_abnormal_cardiomyocyte_apopto0.91639383
144MP0002735_abnormal_chemical_nociception0.90187032
145MP0008469_abnormal_protein_level0.89883709
146MP0005253_abnormal_eye_physiology0.89880402
147MP0005166_decreased_susceptibility_to0.89604105
148MP0004142_abnormal_muscle_tone0.89034711
149MP0005165_increased_susceptibility_to0.88522638
150MP0005397_hematopoietic_system_phenotyp0.88319555
151MP0001545_abnormal_hematopoietic_system0.88319555
152MP0002066_abnormal_motor_capabilities/c0.88305226
153MP0000767_abnormal_smooth_muscle0.88205483
154MP0008004_abnormal_stomach_pH0.87742256
155MP0004808_abnormal_hematopoietic_stem0.87528776
156MP0005388_respiratory_system_phenotype0.87262325
157MP0002133_abnormal_respiratory_system0.87262325
158MP0002118_abnormal_lipid_homeostasis0.87060413
159MP0003690_abnormal_glial_cell0.86691788
160MP0002972_abnormal_cardiac_muscle0.86019817
161MP0002229_neurodegeneration0.84693417
162MP0004510_myositis0.83497805
163MP0000003_abnormal_adipose_tissue0.82765053
164MP0000920_abnormal_myelination0.82499518
165MP0003137_abnormal_impulse_conducting0.82344199
166MP0003828_pulmonary_edema0.81599883
167MP0008775_abnormal_heart_ventricle0.81494250
168MP0000858_altered_metastatic_potential0.81482789
169MP0005084_abnormal_gallbladder_morpholo0.80249726
170MP0005584_abnormal_enzyme/coenzyme_acti0.79769175
171MP0002090_abnormal_vision0.79713467
172MP0003045_fibrosis0.78369481
173MP0001873_stomach_inflammation0.78320154
174MP0001915_intracranial_hemorrhage0.78157487
175MP0003631_nervous_system_phenotype0.78013435
176MP0000604_amyloidosis0.75581132
177MP0009115_abnormal_fat_cell0.74161722
178MP0003448_altered_tumor_morphology0.73967682
179MP0003075_altered_response_to0.72439792
180MP0001986_abnormal_taste_sensitivity0.69429105
181MP0003279_aneurysm0.67668912
182MP0009765_abnormal_xenobiotic_induced0.61960482
183MP0009763_increased_sensitivity_to0.57392370
184MP0008961_abnormal_basal_metabolism0.56523141

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.25402533
2T lymphocytopenia (HP:0005403)4.44270332
3Myositis (HP:0100614)4.43688132
4Abnormality of T cell number (HP:0011839)4.34868824
5Retrobulbar optic neuritis (HP:0100654)4.31494247
6Optic neuritis (HP:0100653)4.31494247
7Recurrent bacterial skin infections (HP:0005406)4.28750776
8Focal motor seizures (HP:0011153)4.23372738
9Orchitis (HP:0100796)4.16563207
10Elevated erythrocyte sedimentation rate (HP:0003565)4.06707672
11Stomatitis (HP:0010280)4.05212984
12Recurrent abscess formation (HP:0002722)4.05085190
13Pseudobulbar signs (HP:0002200)3.86453595
14Gastrointestinal infarctions (HP:0005244)3.45298426
15Progressive cerebellar ataxia (HP:0002073)3.43865513
16Abnormal delayed hypersensitivity skin test (HP:0002963)3.38168047
17Recurrent fungal infections (HP:0002841)3.30317623
18Keratoconjunctivitis sicca (HP:0001097)3.27921319
19Action tremor (HP:0002345)3.25869739
20Drooling (HP:0002307)3.24492304
21Excessive salivation (HP:0003781)3.24492304
22Recurrent gram-negative bacterial infections (HP:0005420)3.23556824
23Atonic seizures (HP:0010819)3.17014134
24Keratoconjunctivitis (HP:0001096)3.13892749
25Visual hallucinations (HP:0002367)3.12993460
26Focal seizures (HP:0007359)3.12694336
27Cone-rod dystrophy (HP:0000548)3.12604452
28Progressive inability to walk (HP:0002505)3.02121175
29Abnormality of macrophages (HP:0004311)2.96390833
30Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.95287002
31Vasculitis (HP:0002633)2.88801129
32Abnormality of T cells (HP:0002843)2.87029991
33Recurrent skin infections (HP:0001581)2.86976779
34Sudden death (HP:0001699)2.86764872
35Decreased circulating renin level (HP:0003351)2.85915947
36Leukocytosis (HP:0001974)2.84091351
37Dysmetric saccades (HP:0000641)2.82670308
38Hematochezia (HP:0002573)2.82300004
39Hemiplegia (HP:0002301)2.81754062
40Meningitis (HP:0001287)2.81071951
41Prolonged bleeding time (HP:0003010)2.79795868
42Metabolic alkalosis (HP:0200114)2.79073841
43Gingivitis (HP:0000230)2.79018780
44Encephalitis (HP:0002383)2.78500376
45Hemoptysis (HP:0002105)2.76396383
46Scanning speech (HP:0002168)2.74592307
47Abnormality of renin-angiotensin system (HP:0000847)2.74031686
48Recurrent cutaneous fungal infections (HP:0011370)2.71446809
49Chronic mucocutaneous candidiasis (HP:0002728)2.71446809
50Dysdiadochokinesis (HP:0002075)2.71310476
51Cerebral hemorrhage (HP:0001342)2.69950051
52Chest pain (HP:0100749)2.69365726
53Myokymia (HP:0002411)2.68835281
54Febrile seizures (HP:0002373)2.67668538
55Pustule (HP:0200039)2.66927366
56Mediastinal lymphadenopathy (HP:0100721)2.66680058
57Subacute progressive viral hepatitis (HP:0006572)2.65451735
58Gaze-evoked nystagmus (HP:0000640)2.64826056
59Dysmetria (HP:0001310)2.63074676
60Hyperactive renin-angiotensin system (HP:0000841)2.60147680
61Eosinophilia (HP:0001880)2.57510017
62Pigmentary retinal degeneration (HP:0001146)2.57449617
63Pulmonary embolism (HP:0002204)2.53389242
64Stomach cancer (HP:0012126)2.50721132
65Autoimmune hemolytic anemia (HP:0001890)2.49838128
66Granulocytopenia (HP:0001913)2.49503789
67Absence seizures (HP:0002121)2.48454100
68Abnormality of eosinophils (HP:0001879)2.47056814
69Gingival bleeding (HP:0000225)2.46756193
70Pulmonary infiltrates (HP:0002113)2.46142423
71Neonatal onset (HP:0003623)2.46101395
72Exercise-induced myalgia (HP:0003738)2.45200849
73Arterial thrombosis (HP:0004420)2.44962448
74Optic disc pallor (HP:0000543)2.44877557
75Recurrent viral infections (HP:0004429)2.44202588
76Abnormality of the fingertips (HP:0001211)2.43708291
77Agitation (HP:0000713)2.43587982
78Anxiety (HP:0000739)2.41871406
79Epistaxis (HP:0000421)2.41524402
80Hyperglycinuria (HP:0003108)2.39390180
81Intellectual disability, progressive (HP:0006887)2.39172204
82Deep venous thrombosis (HP:0002625)2.39058497
83Hyperlipoproteinemia (HP:0010980)2.38487634
84Amyotrophic lateral sclerosis (HP:0007354)2.37004831
85Increased IgE level (HP:0003212)2.36169574
86Urticaria (HP:0001025)2.35092082
87Abnormality of macular pigmentation (HP:0008002)2.33190155
88Slow saccadic eye movements (HP:0000514)2.31053937
89Central scotoma (HP:0000603)2.30471597
90Broad-based gait (HP:0002136)2.29147540
91Inflammation of the large intestine (HP:0002037)2.28925042
92Hyperventilation (HP:0002883)2.28671893
93Abnormal hemoglobin (HP:0011902)2.27521042
94Generalized tonic-clonic seizures (HP:0002069)2.27458302
95Syncope (HP:0001279)2.27281161
96Hyperglycinemia (HP:0002154)2.26737282
97Prolonged QT interval (HP:0001657)2.26469896
98Intention tremor (HP:0002080)2.26329621
99Neurofibrillary tangles (HP:0002185)2.26178494
100Papilledema (HP:0001085)2.24968475
101Cellulitis (HP:0100658)2.24668768
102Ketoacidosis (HP:0001993)2.22919411
103Chronic obstructive pulmonary disease (HP:0006510)2.22366187
104Obstructive lung disease (HP:0006536)2.22366187
105Papillary thyroid carcinoma (HP:0002895)2.21970708
106Recurrent bronchitis (HP:0002837)2.21688104
107Depression (HP:0000716)2.21439306
108Autoimmune thrombocytopenia (HP:0001973)2.19747340
109Genetic anticipation (HP:0003743)2.19241925
110Muscle hypertrophy of the lower extremities (HP:0008968)2.18646409
111Peritonitis (HP:0002586)2.17949329
112Abnormality of salivation (HP:0100755)2.17786461
113Hypochromic microcytic anemia (HP:0004840)2.17355424
114Congenital stationary night blindness (HP:0007642)2.17168556
115Hypochromic anemia (HP:0001931)2.16768914
116Increased variability in muscle fiber diameter (HP:0003557)2.16049950
117Dialeptic seizures (HP:0011146)2.15874535
118Panhypogammaglobulinemia (HP:0003139)2.15863556
119Supranuclear gaze palsy (HP:0000605)2.15671014
120Gastrointestinal inflammation (HP:0004386)2.14416700
121Hemiparesis (HP:0001269)2.14178297
122Neoplasm of the tracheobronchial system (HP:0100552)2.13007213
123Calf muscle hypertrophy (HP:0008981)2.10478570
124Hypothermia (HP:0002045)2.09320061
125Truncal ataxia (HP:0002078)2.08469837
126Limb dystonia (HP:0002451)2.07461486
127Abnormality of binocular vision (HP:0011514)2.06482771
128Diplopia (HP:0000651)2.06482771
129Hypercortisolism (HP:0001578)2.05610696
130Ketosis (HP:0001946)2.03919995
131Abnormal eating behavior (HP:0100738)2.03606179
132Papilloma (HP:0012740)2.03335712
133Verrucae (HP:0200043)2.03335712
134Viral hepatitis (HP:0006562)2.03103697
135Ulnar claw (HP:0001178)2.01538367
136Status epilepticus (HP:0002133)2.01322335
137Osteomyelitis (HP:0002754)2.00759254
138Epileptic encephalopathy (HP:0200134)2.00126691
139Cerebral inclusion bodies (HP:0100314)1.97969051
140Atrial fibrillation (HP:0005110)1.97872987
141Abnormality of serine family amino acid metabolism (HP:0010894)1.97743544
142Abnormality of glycine metabolism (HP:0010895)1.97743544
143Rapidly progressive (HP:0003678)1.97467938
144Colitis (HP:0002583)1.97403443
145Gangrene (HP:0100758)1.96538705
146Microcytic anemia (HP:0001935)1.96198244
147Absent rod-and cone-mediated responses on ERG (HP:0007688)1.95992503
148Abnormality of T cell physiology (HP:0011840)1.95547405
149Hyporeflexia of lower limbs (HP:0002600)1.95458323
150Myotonia (HP:0002486)1.95209164
151Abnormal social behavior (HP:0012433)1.94657868
152Impaired social interactions (HP:0000735)1.94657868
153Primary atrial arrhythmia (HP:0001692)1.94221301
154Difficulty running (HP:0009046)1.94194972
155Pheochromocytoma (HP:0002666)1.93489170
156Alveolar cell carcinoma (HP:0006519)1.93074577
157Abnormality of chloride homeostasis (HP:0011422)1.92828186
158Conjunctival telangiectasia (HP:0000524)1.92811158
159Abnormality of aromatic amino acid family metabolism (HP:0004338)1.91206078
160Episodic fever (HP:0001954)1.90974355
161Anorexia (HP:0002039)1.90735568
162Spontaneous hematomas (HP:0007420)1.89098371
163Sepsis (HP:0100806)1.89027633
164Growth hormone excess (HP:0000845)1.87393278
165Abnormality of the vasculature of the conjunctiva (HP:0008054)1.86344871
166Broad metatarsal (HP:0001783)1.86172317
167Nonprogressive disorder (HP:0003680)1.84824086
168Peripheral hypomyelination (HP:0007182)1.84712035
169Abnormality of the columella (HP:0009929)1.84707895
170Postural instability (HP:0002172)1.84243940
171Hypoglycemic coma (HP:0001325)1.83752906
172Amblyopia (HP:0000646)1.83670783
173Thyroiditis (HP:0100646)1.83348017
174Severe combined immunodeficiency (HP:0004430)1.83277010
175Increased IgM level (HP:0003496)1.83082043
176Poor eye contact (HP:0000817)1.82810800
177Adrenal overactivity (HP:0002717)1.82447817
178Vertigo (HP:0002321)1.81549104
179Xanthomatosis (HP:0000991)1.81396187
180Prolonged partial thromboplastin time (HP:0003645)1.80305750
181Abnormality of the endocardium (HP:0004306)1.80266489
182Amelogenesis imperfecta (HP:0000705)1.80104711
183Supraventricular arrhythmia (HP:0005115)1.78421906
184Lymphopenia (HP:0001888)1.77945407
185Amyloidosis (HP:0011034)1.75867423
186Glomerulonephritis (HP:0000099)1.75789109
187Hypergammaglobulinemia (HP:0010702)1.74852028
188Supraventricular tachycardia (HP:0004755)1.74484524
189Abnormality of cells of the lymphoid lineage (HP:0012140)1.73946029
190Polycythemia (HP:0001901)1.73277184
191Abnormality of the peritoneum (HP:0002585)1.73226753
192Abnormality of the pleura (HP:0002103)1.68284283
193Keratitis (HP:0000491)1.67469890
194Increased CSF protein (HP:0002922)1.67139003

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK384.49018798
2PRKD23.83654449
3TIE13.15983844
4MAP4K12.78436477
5CASK2.70656624
6TXK2.67609267
7KDR2.41845569
8ZAP702.17642175
9MAPK152.07800066
10BLK2.02680226
11PRPF4B2.00673152
12MAP2K31.94906395
13TYK21.94686609
14IKBKE1.84254079
15TAOK31.72921213
16MAP3K141.70952260
17IRAK41.70498885
18NTRK31.69501068
19BTK1.69331251
20JAK31.60872269
21FGR1.57830615
22ITK1.56771869
23JAK11.56569293
24GRK71.55688706
25SYK1.55083337
26RIPK11.53820165
27TSSK61.53571164
28MAP2K41.53034317
29HCK1.51669982
30PHKG21.49753978
31PHKG11.49753978
32MAP3K131.47007882
33TNIK1.45845654
34TEC1.45690218
35CAMK1G1.45027678
36TGFBR21.42013552
37IRAK21.40383100
38YES11.39170251
39UHMK11.37921563
40MAP3K41.34157252
41GRK51.32821068
42PRKD11.32657338
43STK391.31450027
44MAP3K21.30211720
45SIK21.28830359
46LCK1.26707224
47HIPK21.25557786
48INSRR1.23377952
49NTRK21.20102027
50NLK1.19307689
51JAK21.18832065
52FGFR21.17095971
53DAPK21.16505904
54MAP2K71.15628017
55FES1.15317363
56WNK11.13329860
57PIK3CG1.09024034
58MINK11.08435719
59GRK61.07841555
60EPHA41.07430622
61FRK1.06712178
62LYN1.06199303
63PNCK1.05949444
64MAP3K61.04592495
65FER1.03578985
66CAMK2A1.03189988
67KIT1.02778488
68MARK11.02725175
69CAMK2B1.02387570
70SIK31.01033346
71MAPKAPK50.99672035
72MAP3K90.99647074
73MAP3K120.99003211
74MARK30.98685350
75EPHA30.98602718
76EPHB10.96656020
77MAP3K30.95591684
78GRK10.95183077
79MAPK120.95139052
80TBK10.95032239
81WNK40.95012705
82PAK60.93980762
83MAPK70.92507031
84NTRK10.90302668
85CAMKK20.89787704
86SGK2230.89017445
87SGK4940.89017445
88BMPR20.88684911
89PRKCH0.86115788
90IRAK10.85675912
91* STK110.85438203
92SIK10.84359610
93CDK50.84143750
94CAMK2D0.83057083
95PTK2B0.82287056
96MYLK0.81955533
97LMTK20.81147714
98PDK10.80273545
99CAMK10.78106157
100CAMK40.77528228
101CAMK1D0.75567702
102RET0.75133427
103SGK20.73734581
104PINK10.73243284
105DMPK0.73050616
106PRKAA20.72524192
107IKBKB0.72353452
108PDGFRB0.72238168
109MARK20.70648584
110FGFR40.69553517
111TRIB30.69151138
112RAF10.67965503
113TYRO30.67227380
114AKT30.66177110
115TAOK10.64960579
116OXSR10.64147447
117BRD40.63641081
118PRKCQ0.63207659
119PAK30.62702228
120MAP3K70.62553148
121ACVR1B0.61698009
122EPHB20.61334495
123CAMK2G0.61291828
124BCKDK0.58674736
125TRPM70.57463467
126PIM10.55644897
127DYRK1B0.55404847
128CSK0.55155973
129CAMKK10.55152160
130PKN10.53065742
131KSR20.53047653
132KSR10.52649413
133PIK3CA0.52583180
134CSNK1G10.50730425
135PRKCE0.50329198
136SGK30.50273683
137FGFR30.49994735
138DYRK1A0.49237848
139MUSK0.48343783
140TNK20.48133336
141CSF1R0.48086305
142CDK60.47775636
143STK100.47158730
144CSNK1G20.46691761
145CDK120.45839869
146EGFR0.45535524
147RIPK40.45418885
148FYN0.45390010
149PDPK10.45233020
150MAP3K10.45095644
151SGK10.44069981
152ADRBK10.43246732
153CLK10.41762010
154PRKAA10.40703287
155MAPK130.40341339
156NEK60.38886765

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.45388758
2Osteoclast differentiation_Homo sapiens_hsa043802.17710355
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.98205088
4Nitrogen metabolism_Homo sapiens_hsa009101.97476416
5T cell receptor signaling pathway_Homo sapiens_hsa046601.96890759
6B cell receptor signaling pathway_Homo sapiens_hsa046621.96741690
7GABAergic synapse_Homo sapiens_hsa047271.89976520
8Leishmaniasis_Homo sapiens_hsa051401.88910769
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.88052356
10Morphine addiction_Homo sapiens_hsa050321.76945456
11Phototransduction_Homo sapiens_hsa047441.74950328
12Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.74775459
13Glutamatergic synapse_Homo sapiens_hsa047241.73680694
14NOD-like receptor signaling pathway_Homo sapiens_hsa046211.66578746
15Renin secretion_Homo sapiens_hsa049241.66121779
16Circadian entrainment_Homo sapiens_hsa047131.64385416
17Salivary secretion_Homo sapiens_hsa049701.62338270
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.62191821
19Acute myeloid leukemia_Homo sapiens_hsa052211.60267140
20Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.55903251
21Propanoate metabolism_Homo sapiens_hsa006401.54963596
22Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.53316761
23Measles_Homo sapiens_hsa051621.51177232
24Primary immunodeficiency_Homo sapiens_hsa053401.49403777
25Olfactory transduction_Homo sapiens_hsa047401.48219647
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.45039362
27Platelet activation_Homo sapiens_hsa046111.42893914
28Arginine biosynthesis_Homo sapiens_hsa002201.42691956
29Non-small cell lung cancer_Homo sapiens_hsa052231.42670948
30Tuberculosis_Homo sapiens_hsa051521.41695051
31Long-term depression_Homo sapiens_hsa047301.39950194
32Taste transduction_Homo sapiens_hsa047421.38375467
33Staphylococcus aureus infection_Homo sapiens_hsa051501.37416636
34RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.36955063
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.36660116
36Graft-versus-host disease_Homo sapiens_hsa053321.35391306
37Chemokine signaling pathway_Homo sapiens_hsa040621.35107214
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.34219001
39Jak-STAT signaling pathway_Homo sapiens_hsa046301.34170586
40Long-term potentiation_Homo sapiens_hsa047201.33075609
41Aldosterone synthesis and secretion_Homo sapiens_hsa049251.32957356
42PPAR signaling pathway_Homo sapiens_hsa033201.29005099
43Dopaminergic synapse_Homo sapiens_hsa047281.28155225
44Malaria_Homo sapiens_hsa051441.26190878
45NF-kappa B signaling pathway_Homo sapiens_hsa040641.25721275
46Toxoplasmosis_Homo sapiens_hsa051451.25099392
47Allograft rejection_Homo sapiens_hsa053301.25062578
48Amphetamine addiction_Homo sapiens_hsa050311.24485767
49Gastric acid secretion_Homo sapiens_hsa049711.24318526
50Synaptic vesicle cycle_Homo sapiens_hsa047211.23539165
51Butanoate metabolism_Homo sapiens_hsa006501.22527804
52TNF signaling pathway_Homo sapiens_hsa046681.21908623
53Cholinergic synapse_Homo sapiens_hsa047251.21743200
54Cardiac muscle contraction_Homo sapiens_hsa042601.21583185
55Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.21454353
56Fatty acid degradation_Homo sapiens_hsa000711.19433507
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.19307862
58Chronic myeloid leukemia_Homo sapiens_hsa052201.19240123
59Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.18846698
60Bile secretion_Homo sapiens_hsa049761.18663392
61Autoimmune thyroid disease_Homo sapiens_hsa053201.18631586
62Pancreatic cancer_Homo sapiens_hsa052121.17054930
63Hematopoietic cell lineage_Homo sapiens_hsa046401.16183345
64Leukocyte transendothelial migration_Homo sapiens_hsa046701.15919620
65Prolactin signaling pathway_Homo sapiens_hsa049171.15560036
66Hepatitis B_Homo sapiens_hsa051611.15387790
67Insulin secretion_Homo sapiens_hsa049111.13371041
68Calcium signaling pathway_Homo sapiens_hsa040201.11733276
69FoxO signaling pathway_Homo sapiens_hsa040681.11712628
70VEGF signaling pathway_Homo sapiens_hsa043701.10836113
71AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.10437211
72Fatty acid metabolism_Homo sapiens_hsa012121.09701882
73Neurotrophin signaling pathway_Homo sapiens_hsa047221.08504319
74Serotonergic synapse_Homo sapiens_hsa047261.08327085
75cAMP signaling pathway_Homo sapiens_hsa040241.08241135
76Renal cell carcinoma_Homo sapiens_hsa052111.07678887
77Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.07121661
78Influenza A_Homo sapiens_hsa051641.06424403
79Endometrial cancer_Homo sapiens_hsa052131.05624786
80Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.04317705
81Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.03430361
82Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00722209
83Cocaine addiction_Homo sapiens_hsa050300.99274766
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.99077496
85Pancreatic secretion_Homo sapiens_hsa049720.99003343
86Oxytocin signaling pathway_Homo sapiens_hsa049210.98292855
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.96422112
88Dilated cardiomyopathy_Homo sapiens_hsa054140.94333314
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.93902416
90mTOR signaling pathway_Homo sapiens_hsa041500.92725794
91cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92043902
92Glycerolipid metabolism_Homo sapiens_hsa005610.91607651
93Type I diabetes mellitus_Homo sapiens_hsa049400.91559104
94Hepatitis C_Homo sapiens_hsa051600.91071148
95Colorectal cancer_Homo sapiens_hsa052100.90449557
96ErbB signaling pathway_Homo sapiens_hsa040120.89564193
97Legionellosis_Homo sapiens_hsa051340.89306431
98Fatty acid biosynthesis_Homo sapiens_hsa000610.88557539
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.88320234
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.86194992
101Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85990385
102Glioma_Homo sapiens_hsa052140.85894052
103Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.85762829
104Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.83795215
105African trypanosomiasis_Homo sapiens_hsa051430.83174512
106Fatty acid elongation_Homo sapiens_hsa000620.82923595
107Estrogen signaling pathway_Homo sapiens_hsa049150.82133832
108Viral myocarditis_Homo sapiens_hsa054160.80215294
109Vascular smooth muscle contraction_Homo sapiens_hsa042700.78699549
110Herpes simplex infection_Homo sapiens_hsa051680.78642503
111Melanogenesis_Homo sapiens_hsa049160.78237557
112Alzheimers disease_Homo sapiens_hsa050100.76063611
113Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.76029285
114Phospholipase D signaling pathway_Homo sapiens_hsa040720.75910991
115Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75627553
116Tryptophan metabolism_Homo sapiens_hsa003800.75092841
117Pertussis_Homo sapiens_hsa051330.75079106
118Apoptosis_Homo sapiens_hsa042100.74759290
119Type II diabetes mellitus_Homo sapiens_hsa049300.74755273
120Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74659242
121Inositol phosphate metabolism_Homo sapiens_hsa005620.73819202
122GnRH signaling pathway_Homo sapiens_hsa049120.73751025
123Oxidative phosphorylation_Homo sapiens_hsa001900.72806222
124Prostate cancer_Homo sapiens_hsa052150.72685237
125Axon guidance_Homo sapiens_hsa043600.72158851
126Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.72059552
127Dorso-ventral axis formation_Homo sapiens_hsa043200.71821082
128Shigellosis_Homo sapiens_hsa051310.70696513
129Gap junction_Homo sapiens_hsa045400.70304109
130MAPK signaling pathway_Homo sapiens_hsa040100.70229759
131Intestinal immune network for IgA production_Homo sapiens_hsa046720.69434591
132Complement and coagulation cascades_Homo sapiens_hsa046100.68179866
133Phagosome_Homo sapiens_hsa041450.67832083
134Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67666825
135beta-Alanine metabolism_Homo sapiens_hsa004100.65972341
136Choline metabolism in cancer_Homo sapiens_hsa052310.65569935
137Amoebiasis_Homo sapiens_hsa051460.65374442
138Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63943831
139Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62920713
140Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62382781
141Phenylalanine metabolism_Homo sapiens_hsa003600.62225477
142Antigen processing and presentation_Homo sapiens_hsa046120.61729243
143Adipocytokine signaling pathway_Homo sapiens_hsa049200.61597766
144Pyruvate metabolism_Homo sapiens_hsa006200.61313360
145HIF-1 signaling pathway_Homo sapiens_hsa040660.60946683
146Endocytosis_Homo sapiens_hsa041440.60522870
147Glucagon signaling pathway_Homo sapiens_hsa049220.60116014
148Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57953038
149Ether lipid metabolism_Homo sapiens_hsa005650.57573773
150Glycerophospholipid metabolism_Homo sapiens_hsa005640.56971032
151Tyrosine metabolism_Homo sapiens_hsa003500.56832828
152ABC transporters_Homo sapiens_hsa020100.55814866
153Thyroid hormone synthesis_Homo sapiens_hsa049180.54352281
154Circadian rhythm_Homo sapiens_hsa047100.53678238
155Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53217553
156AMPK signaling pathway_Homo sapiens_hsa041520.53137992
157Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52873594
158Parkinsons disease_Homo sapiens_hsa050120.52592502
159Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52357028
160Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52155646
161Salmonella infection_Homo sapiens_hsa051320.51852808
162Notch signaling pathway_Homo sapiens_hsa043300.51436072
163Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50559300
1642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.49736141
165Histidine metabolism_Homo sapiens_hsa003400.48277372
166Fat digestion and absorption_Homo sapiens_hsa049750.45454058
167Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.43010069
168Ras signaling pathway_Homo sapiens_hsa040140.42981627
169Rap1 signaling pathway_Homo sapiens_hsa040150.41019117
170Insulin resistance_Homo sapiens_hsa049310.40227283
171Ovarian steroidogenesis_Homo sapiens_hsa049130.39591071
172Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38978642

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