SNRNP27

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a serine/arginine-rich (SR) protein. SR proteins play important roles in pre-mRNA splicing by facilitating the recognition and selection of splice sites. The encoded protein associates with the 25S U4/U6.U5 tri-snRNP, a major component of the U2-type spiceosome. The expression of this gene may be altered in cells infected with the human T-cell lymphotropic virus type 1 (HTLV-1) retrovirus. A pseudogene of this gene is located on the long arm of chromosome 5. Alternatively spliced transcript variants have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial electron transport, NADH to ubiquinone (GO:0006120)7.00006584
2energy coupled proton transport, down electrochemical gradient (GO:0015985)6.52972504
3ATP synthesis coupled proton transport (GO:0015986)6.52972504
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.51481847
5ribosomal small subunit biogenesis (GO:0042274)6.21872295
6respiratory electron transport chain (GO:0022904)5.74198350
7electron transport chain (GO:0022900)5.62609212
8protein neddylation (GO:0045116)5.39422056
9viral transcription (GO:0019083)5.25868599
10translational termination (GO:0006415)5.05088640
11chaperone-mediated protein transport (GO:0072321)5.01137548
12ribosomal small subunit assembly (GO:0000028)4.75359847
13cotranslational protein targeting to membrane (GO:0006613)4.68798888
14SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.59735667
15protein targeting to ER (GO:0045047)4.58857321
16mitochondrial respiratory chain complex I assembly (GO:0032981)4.49012047
17NADH dehydrogenase complex assembly (GO:0010257)4.49012047
18mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.49012047
19protein complex biogenesis (GO:0070271)4.48172649
20proteasome assembly (GO:0043248)4.38763190
21establishment of protein localization to mitochondrial membrane (GO:0090151)4.37811597
22establishment of protein localization to endoplasmic reticulum (GO:0072599)4.37613348
23protein localization to endoplasmic reticulum (GO:0070972)4.35785559
24cellular protein complex disassembly (GO:0043624)4.17457932
25GTP biosynthetic process (GO:0006183)4.13730906
26translational elongation (GO:0006414)4.13095405
27axon ensheathment in central nervous system (GO:0032291)3.99036008
28central nervous system myelination (GO:0022010)3.99036008
29viral life cycle (GO:0019058)3.98961125
30mitochondrial respiratory chain complex assembly (GO:0033108)3.98127359
31ribosomal large subunit biogenesis (GO:0042273)3.95278325
32maturation of SSU-rRNA (GO:0030490)3.74373616
33transcription elongation from RNA polymerase III promoter (GO:0006385)3.74038967
34termination of RNA polymerase III transcription (GO:0006386)3.74038967
357-methylguanosine mRNA capping (GO:0006370)3.68640742
367-methylguanosine RNA capping (GO:0009452)3.65260297
37RNA capping (GO:0036260)3.65260297
38translational initiation (GO:0006413)3.64323582
39water-soluble vitamin biosynthetic process (GO:0042364)3.61907324
40DNA deamination (GO:0045006)3.57676890
41translation (GO:0006412)3.56468676
42nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.52227102
43protein-cofactor linkage (GO:0018065)3.49889809
44RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.48109448
45tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.48109448
46protein targeting to mitochondrion (GO:0006626)3.45799072
47protein complex disassembly (GO:0043241)3.39967812
48establishment of protein localization to mitochondrion (GO:0072655)3.35831410
49UTP biosynthetic process (GO:0006228)3.35687910
50hydrogen ion transmembrane transport (GO:1902600)3.33971124
51purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.24461044
52establishment of integrated proviral latency (GO:0075713)3.22875988
53macromolecular complex disassembly (GO:0032984)3.22283588
54behavioral response to nicotine (GO:0035095)3.18178734
55purine nucleoside triphosphate biosynthetic process (GO:0009145)3.16521320
56negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.14845901
57mannosylation (GO:0097502)3.13716359
58chromatin remodeling at centromere (GO:0031055)3.12824397
59protein localization to mitochondrion (GO:0070585)3.11424223
60guanosine-containing compound biosynthetic process (GO:1901070)3.10929770
61platelet dense granule organization (GO:0060155)3.10639371
62CENP-A containing nucleosome assembly (GO:0034080)3.10564389
63respiratory chain complex IV assembly (GO:0008535)3.07550758
64nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.05072491
65establishment of viral latency (GO:0019043)3.04028163
66regulation of cellular amino acid metabolic process (GO:0006521)3.03020725
67proton transport (GO:0015992)3.02974931
68L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.02718998
69ATP biosynthetic process (GO:0006754)2.98955369
70cellular component biogenesis (GO:0044085)2.98335262
71regulation of mitochondrial translation (GO:0070129)2.97921548
72protein targeting to membrane (GO:0006612)2.96551449
73negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.94936518
74negative regulation of ligase activity (GO:0051352)2.94936518
75sequestering of actin monomers (GO:0042989)2.94812033
76hydrogen transport (GO:0006818)2.93192421
77cullin deneddylation (GO:0010388)2.91939669
78histone mRNA metabolic process (GO:0008334)2.91629304
79exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.90289953
80protein deneddylation (GO:0000338)2.89412407
81positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.89013359
82presynaptic membrane assembly (GO:0097105)2.86920233
83DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.85960037
84regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.84081018
85regulation of mitotic spindle checkpoint (GO:1903504)2.84081018
86ribonucleoprotein complex biogenesis (GO:0022613)2.83948829
87DNA double-strand break processing (GO:0000729)2.82869061
88maturation of 5.8S rRNA (GO:0000460)2.82337994
89resolution of meiotic recombination intermediates (GO:0000712)2.79894299
90antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.79266806
91signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.77563449
92intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.77563449
93negative regulation of execution phase of apoptosis (GO:1900118)2.77560891
94organelle disassembly (GO:1903008)2.77378311
95inner mitochondrial membrane organization (GO:0007007)2.76948448
96oxidative phosphorylation (GO:0006119)2.75947067
97signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.74821675
98signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.74821675
99signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.74821675
100regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.74653630
101ribonucleoside triphosphate biosynthetic process (GO:0009201)2.74429615
102ubiquinone biosynthetic process (GO:0006744)2.74185852
103cytochrome complex assembly (GO:0017004)2.73104483
104pseudouridine synthesis (GO:0001522)2.72923542
105protein K11-linked ubiquitination (GO:0070979)2.72171349
106anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.69628196
107deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.69537157
108histone exchange (GO:0043486)2.68875964
109regulation of cilium movement (GO:0003352)2.68814215
110UTP metabolic process (GO:0046051)2.68320564
111signal transduction involved in DNA damage checkpoint (GO:0072422)2.67768352
112signal transduction involved in DNA integrity checkpoint (GO:0072401)2.67768352
113peptidyl-histidine modification (GO:0018202)2.67645673
114signal transduction involved in cell cycle checkpoint (GO:0072395)2.67295064
115DNA damage response, detection of DNA damage (GO:0042769)2.66625539
116GPI anchor biosynthetic process (GO:0006506)2.65680423
117positive regulation of protein homodimerization activity (GO:0090073)2.65518645
118positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.64545951
119CTP biosynthetic process (GO:0006241)2.64484633
120CTP metabolic process (GO:0046036)2.64484633
121nucleoside diphosphate phosphorylation (GO:0006165)2.63479868
122substantia nigra development (GO:0021762)2.63399740
123presynaptic membrane organization (GO:0097090)2.62622640
124replication fork processing (GO:0031297)2.62220032
125preassembly of GPI anchor in ER membrane (GO:0016254)2.62062871
126pyrimidine nucleobase catabolic process (GO:0006208)2.60939177
127long-chain fatty acid biosynthetic process (GO:0042759)2.60763685
128intracellular protein transmembrane import (GO:0044743)2.60423897
129ubiquinone metabolic process (GO:0006743)2.58910538
130synapsis (GO:0007129)2.56708916
131rRNA modification (GO:0000154)2.56409397
132protein K6-linked ubiquitination (GO:0085020)2.53729716
133intraciliary transport (GO:0042073)2.53563682
134anterograde synaptic vesicle transport (GO:0048490)2.53432803
135spliceosomal snRNP assembly (GO:0000387)2.53039531
136male meiosis I (GO:0007141)2.52103525
137neuron fate determination (GO:0048664)2.51563470
138positive regulation of ligase activity (GO:0051351)2.50383751
139tRNA processing (GO:0008033)2.49577691
140DNA replication checkpoint (GO:0000076)2.46916340
141mitochondrial transport (GO:0006839)2.45898073
142nonmotile primary cilium assembly (GO:0035058)2.45038571
143inositol phosphate catabolic process (GO:0071545)2.44741927
144GPI anchor metabolic process (GO:0006505)2.44409588
145protein localization to cilium (GO:0061512)2.44318415
146response to pheromone (GO:0019236)2.41667840

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.66560102
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.08699489
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.96731522
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.64336312
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.46122811
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.38373051
7* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.01662714
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.99165086
9ZNF274_21170338_ChIP-Seq_K562_Hela2.92327318
10CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.80688968
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.77750250
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.74194430
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.64489326
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.61117645
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.49494504
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.47813186
17VDR_22108803_ChIP-Seq_LS180_Human2.39296545
18MYC_18555785_ChIP-Seq_MESCs_Mouse2.32085542
19EZH2_22144423_ChIP-Seq_EOC_Human2.03523677
20BMI1_23680149_ChIP-Seq_NPCS_Mouse2.02142700
21FUS_26573619_Chip-Seq_HEK293_Human2.01723961
22PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94679679
23ELK1_19687146_ChIP-ChIP_HELA_Human1.93100493
24* VDR_23849224_ChIP-Seq_CD4+_Human1.88963163
25PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.86740432
26SRF_21415370_ChIP-Seq_HL-1_Mouse1.82177007
27TAF15_26573619_Chip-Seq_HEK293_Human1.78242857
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.70508961
29GBX2_23144817_ChIP-Seq_PC3_Human1.69310335
30MYC_18358816_ChIP-ChIP_MESCs_Mouse1.69089968
31SALL1_21062744_ChIP-ChIP_HESCs_Human1.67277234
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.66875707
33ELK1_22589737_ChIP-Seq_MCF10A_Human1.65622230
34DCP1A_22483619_ChIP-Seq_HELA_Human1.64675382
35ELF1_17652178_ChIP-ChIP_JURKAT_Human1.64110207
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.61466276
37CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.58786183
38PADI4_21655091_ChIP-ChIP_MCF-7_Human1.58452264
39YY1_21170310_ChIP-Seq_MESCs_Mouse1.58270186
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.55853517
41POU5F1_16153702_ChIP-ChIP_HESCs_Human1.54986873
42TTF2_22483619_ChIP-Seq_HELA_Human1.53869321
43GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.51760895
44TP53_22573176_ChIP-Seq_HFKS_Human1.47062217
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45979372
46MYC_19030024_ChIP-ChIP_MESCs_Mouse1.44995103
47E2F1_18555785_ChIP-Seq_MESCs_Mouse1.42300742
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.39783489
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.39777961
50POU3F2_20337985_ChIP-ChIP_501MEL_Human1.39399168
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.38292676
52MYC_18940864_ChIP-ChIP_HL60_Human1.37437385
53MYC_19079543_ChIP-ChIP_MESCs_Mouse1.35574170
54* FOXP3_21729870_ChIP-Seq_TREG_Human1.32959618
55IRF1_19129219_ChIP-ChIP_H3396_Human1.31453093
56XRN2_22483619_ChIP-Seq_HELA_Human1.31282065
57RNF2_27304074_Chip-Seq_NSC_Mouse1.28232726
58EZH2_27304074_Chip-Seq_ESCs_Mouse1.28012058
59FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.27960924
60RBPJ_22232070_ChIP-Seq_NCS_Mouse1.26142853
61POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24859201
62ER_23166858_ChIP-Seq_MCF-7_Human1.24685128
63EWS_26573619_Chip-Seq_HEK293_Human1.24349944
64FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.21815936
65JARID2_20064375_ChIP-Seq_MESCs_Mouse1.19922562
66BP1_19119308_ChIP-ChIP_Hs578T_Human1.19779577
67EZH2_27294783_Chip-Seq_NPCs_Mouse1.19676455
68PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.19531457
69NFE2_27457419_Chip-Seq_LIVER_Mouse1.19490776
70NANOG_19829295_ChIP-Seq_ESCs_Human1.19185612
71SOX2_19829295_ChIP-Seq_ESCs_Human1.19185612
72CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.16700849
73GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15150857
74EED_16625203_ChIP-ChIP_MESCs_Mouse1.14764849
75HOXB4_20404135_ChIP-ChIP_EML_Mouse1.13341123
76ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.13338442
77MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12756488
78CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11620841
79P300_19829295_ChIP-Seq_ESCs_Human1.11379792
80* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07260834
81EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06338608
82EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.04994636
83PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04557878
84TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03536867
85CBP_20019798_ChIP-Seq_JUKART_Human1.02368606
86IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02368606
87OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02041510
88CTBP1_25329375_ChIP-Seq_LNCAP_Human1.01337189
89NOTCH1_21737748_ChIP-Seq_TLL_Human1.00832997
90P53_22387025_ChIP-Seq_ESCs_Mouse1.00597880
91FOXA1_25329375_ChIP-Seq_VCAP_Human0.99939589
92FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99939589
93KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99920187
94HTT_18923047_ChIP-ChIP_STHdh_Human0.99240024
95AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99118808
96FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.99068293
97IGF1R_20145208_ChIP-Seq_DFB_Human0.98989081
98MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.98928077
99AR_25329375_ChIP-Seq_VCAP_Human0.98616867
100MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98498824
101BCAT_22108803_ChIP-Seq_LS180_Human0.98428631
102SOX2_16153702_ChIP-ChIP_HESCs_Human0.97973163
103TAL1_26923725_Chip-Seq_HPCs_Mouse0.97779117
104SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97562285
105CRX_20693478_ChIP-Seq_RETINA_Mouse0.96446221
106SMAD4_21799915_ChIP-Seq_A2780_Human0.96021536
107RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.95863851
108NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.94543732
109FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.93679522
110NELFA_20434984_ChIP-Seq_ESCs_Mouse0.89500494
111TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89457109
112SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.88441887
113GABP_19822575_ChIP-Seq_HepG2_Human0.87750568
114RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.87211408
115EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.86909856
116CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.86421331
117E2F4_17652178_ChIP-ChIP_JURKAT_Human0.86389307
118KAP1_22055183_ChIP-Seq_ESCs_Mouse0.86113262
119PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.83902085
120EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.81298876
121JUN_21703547_ChIP-Seq_K562_Human0.80965650
122* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.80670893
123SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.80462886
124KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.80190477
125SOX17_20123909_ChIP-Seq_XEN_Mouse0.80128705
126NANOG_18555785_Chip-Seq_ESCs_Mouse0.79802465
127SUZ12_18555785_Chip-Seq_ESCs_Mouse0.79271098
128SUZ12_27294783_Chip-Seq_NPCs_Mouse0.79060812
129SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.78824508
130STAT3_18555785_Chip-Seq_ESCs_Mouse0.78500297
131YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.78377363
132JARID2_20075857_ChIP-Seq_MESCs_Mouse0.77688002

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.18725331
2MP0003136_yellow_coat_color3.81585213
3MP0001529_abnormal_vocalization3.70672801
4MP0003880_abnormal_central_pattern3.60238981
5MP0001905_abnormal_dopamine_level3.00678546
6MP0005171_absent_coat_pigmentation2.67724619
7MP0002102_abnormal_ear_morphology2.47242595
8MP0006276_abnormal_autonomic_nervous2.44067875
9MP0002837_dystrophic_cardiac_calcinosis2.35866718
10MP0000372_irregular_coat_pigmentation2.33628097
11MP0002736_abnormal_nociception_after2.26331715
12MP0001188_hyperpigmentation2.14749796
13MP0001986_abnormal_taste_sensitivity2.11863839
14MP0006292_abnormal_olfactory_placode2.05258531
15MP0003315_abnormal_perineum_morphology2.02792260
16MP0002822_catalepsy1.97719798
17MP0001968_abnormal_touch/_nociception1.97650730
18MP0003718_maternal_effect1.97372383
19MP0002163_abnormal_gland_morphology1.92346623
20MP0002638_abnormal_pupillary_reflex1.88660181
21MP0005409_darkened_coat_color1.82803593
22MP0003787_abnormal_imprinting1.81525056
23MP0006072_abnormal_retinal_apoptosis1.80262860
24MP0004742_abnormal_vestibular_system1.78698893
25MP0004142_abnormal_muscle_tone1.73961675
26MP0003121_genomic_imprinting1.67479382
27MP0001485_abnormal_pinna_reflex1.66947763
28MP0003122_maternal_imprinting1.66714852
29MP0003195_calcinosis1.66065270
30MP0005645_abnormal_hypothalamus_physiol1.66012364
31MP0008995_early_reproductive_senescence1.64013145
32MP0005423_abnormal_somatic_nervous1.62666251
33MP0002272_abnormal_nervous_system1.61949686
34MP0004381_abnormal_hair_follicle1.55085617
35MP0008932_abnormal_embryonic_tissue1.52762913
36MP0000920_abnormal_myelination1.48339661
37MP0004885_abnormal_endolymph1.46467567
38MP0005379_endocrine/exocrine_gland_phen1.45370144
39MP0002909_abnormal_adrenal_gland1.42314078
40MP0002938_white_spotting1.42225267
41MP0005408_hypopigmentation1.41739607
42MP0002734_abnormal_mechanical_nocicepti1.40381335
43MP0005451_abnormal_body_composition1.39576491
44MP0002735_abnormal_chemical_nociception1.39204753
45MP0006035_abnormal_mitochondrial_morpho1.32862548
46MP0003950_abnormal_plasma_membrane1.31861986
47MP0004145_abnormal_muscle_electrophysio1.29973468
48MP0005551_abnormal_eye_electrophysiolog1.29178744
49MP0000026_abnormal_inner_ear1.28488246
50MP0002277_abnormal_respiratory_mucosa1.25670408
51MP0008789_abnormal_olfactory_epithelium1.25413866
52MP0001984_abnormal_olfaction1.23775094
53MP0000569_abnormal_digit_pigmentation1.23123588
54MP0009745_abnormal_behavioral_response1.22786102
55MP0008872_abnormal_physiological_respon1.19142951
56MP0005389_reproductive_system_phenotype1.17408137
57MP0004270_analgesia1.17312935
58MP0001440_abnormal_grooming_behavior1.16047343
59MP0008877_abnormal_DNA_methylation1.14958889
60MP0001486_abnormal_startle_reflex1.14545396
61MP0003890_abnormal_embryonic-extraembry1.13042424
62MP0000778_abnormal_nervous_system1.13031918
63MP0001963_abnormal_hearing_physiology1.12926481
64MP0000049_abnormal_middle_ear1.12120343
65MP0003938_abnormal_ear_development1.11429874
66MP0002064_seizures1.10751627
67MP0002751_abnormal_autonomic_nervous1.10087472
68MP0002752_abnormal_somatic_nervous1.09647222
69MP0005253_abnormal_eye_physiology1.07513504
70MP0002210_abnormal_sex_determination1.07114733
71MP0001764_abnormal_homeostasis1.06786554
72MP0004215_abnormal_myocardial_fiber1.06704948
73MP0001919_abnormal_reproductive_system1.06381457
74MP0008875_abnormal_xenobiotic_pharmacok1.06357188
75MP0002148_abnormal_hypersensitivity_rea1.06298027
76MP0002067_abnormal_sensory_capabilities1.06144158
77MP0003567_abnormal_fetal_cardiomyocyte1.06066840
78MP0001970_abnormal_pain_threshold1.05849935
79MP0002234_abnormal_pharynx_morphology1.05149569
80MP0003646_muscle_fatigue1.05084937
81MP0003693_abnormal_embryo_hatching1.03726553
82MP0002572_abnormal_emotion/affect_behav1.03465598
83MP0005084_abnormal_gallbladder_morpholo1.02813018
84MP0003186_abnormal_redox_activity1.00235548
85MP0000631_abnormal_neuroendocrine_gland0.99852781
86MP0001727_abnormal_embryo_implantation0.99487219
87MP0010386_abnormal_urinary_bladder0.99461884
88MP0003011_delayed_dark_adaptation0.99440579
89MP0009250_abnormal_appendicular_skeleto0.95953543
90MP0000653_abnormal_sex_gland0.94138656
91MP0003137_abnormal_impulse_conducting0.92984836
92MP0005646_abnormal_pituitary_gland0.92892245
93MP0001929_abnormal_gametogenesis0.92850202
94MP0002090_abnormal_vision0.88941433
95MP0002184_abnormal_innervation0.88029516
96MP0000639_abnormal_adrenal_gland0.87854990
97MP0010094_abnormal_chromosome_stability0.87471433
98MP0000462_abnormal_digestive_system0.87334124
99MP0001145_abnormal_male_reproductive0.86641563
100MP0006036_abnormal_mitochondrial_physio0.85872646
101MP0003941_abnormal_skin_development0.84900304
102MP0003937_abnormal_limbs/digits/tail_de0.84761422
103MP0002063_abnormal_learning/memory/cond0.84399505
104MP0000955_abnormal_spinal_cord0.84213205
105MP0003698_abnormal_male_reproductive0.84092957
106MP0002132_abnormal_respiratory_system0.83701154
107MP0004957_abnormal_blastocyst_morpholog0.82521003
108MP0000015_abnormal_ear_pigmentation0.79764378
109MP0005410_abnormal_fertilization0.79292944
110MP0009046_muscle_twitch0.79112634
111MP0009697_abnormal_copulation0.78826824
112MP0002160_abnormal_reproductive_system0.78445865
113MP0004133_heterotaxia0.78230622
114MP0004134_abnormal_chest_morphology0.78184561
115MP0002733_abnormal_thermal_nociception0.77102930
116MP0003786_premature_aging0.74597152
117MP0002229_neurodegeneration0.74316180
118MP0003724_increased_susceptibility_to0.73577714
119MP0005195_abnormal_posterior_eye0.73146920
120MP0002095_abnormal_skin_pigmentation0.72802487
121MP0004147_increased_porphyrin_level0.72548275
122MP0003635_abnormal_synaptic_transmissio0.71966086
123MP0002653_abnormal_ependyma_morphology0.71857697
124MP0004924_abnormal_behavior0.71833663
125MP0005386_behavior/neurological_phenoty0.71833663
126MP0002882_abnormal_neuron_morphology0.71344535
127MP0002876_abnormal_thyroid_physiology0.70401107
128MP0008058_abnormal_DNA_repair0.70299088
129MP0005394_taste/olfaction_phenotype0.69032453
130MP0005499_abnormal_olfactory_system0.69032453
131MP0002557_abnormal_social/conspecific_i0.68256340
132MP0008004_abnormal_stomach_pH0.68011219

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.46322484
2Abnormal mitochondria in muscle tissue (HP:0008316)5.63274455
3Mitochondrial inheritance (HP:0001427)5.53279651
4Progressive macrocephaly (HP:0004481)5.42869022
5Increased hepatocellular lipid droplets (HP:0006565)5.01609685
6Acute encephalopathy (HP:0006846)4.86050888
7Increased CSF lactate (HP:0002490)4.68546222
8Renal Fanconi syndrome (HP:0001994)4.41054093
9Hepatocellular necrosis (HP:0001404)4.37947182
10Lipid accumulation in hepatocytes (HP:0006561)4.17822043
11Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.10842710
12Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.89812280
13Abnormality of cells of the erythroid lineage (HP:0012130)3.86592666
14Hepatic necrosis (HP:0002605)3.61058091
15Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.60438128
16Optic disc pallor (HP:0000543)3.56756654
17Exertional dyspnea (HP:0002875)3.56294817
18Leukodystrophy (HP:0002415)3.50155459
193-Methylglutaconic aciduria (HP:0003535)3.47944461
20Increased intramyocellular lipid droplets (HP:0012240)3.39441165
21Abnormal number of erythroid precursors (HP:0012131)3.32783174
22Exercise intolerance (HP:0003546)3.27670836
23Respiratory failure (HP:0002878)3.16443835
24Reticulocytopenia (HP:0001896)3.15979815
25Parakeratosis (HP:0001036)3.15115134
26Methylmalonic acidemia (HP:0002912)3.11893307
27Respiratory difficulties (HP:0002880)3.02924889
28Abnormality of renal resorption (HP:0011038)3.00579139
29Cerebral edema (HP:0002181)2.98673097
30Decreased activity of mitochondrial respiratory chain (HP:0008972)2.97955619
31Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.97955619
32Macrocytic anemia (HP:0001972)2.90433899
33Abnormality of the labia minora (HP:0012880)2.81474021
34Nephronophthisis (HP:0000090)2.71357746
35Increased serum lactate (HP:0002151)2.70966700
36Cerebral hypomyelination (HP:0006808)2.70026975
37Methylmalonic aciduria (HP:0012120)2.67446831
38Lactic acidosis (HP:0003128)2.62432008
39Increased muscle lipid content (HP:0009058)2.60586790
40Aplasia/Hypoplasia of the sacrum (HP:0008517)2.56505034
41Medial flaring of the eyebrow (HP:0010747)2.52908834
42Increased serum pyruvate (HP:0003542)2.51768803
43Abnormality of glycolysis (HP:0004366)2.51768803
44Congenital ichthyosiform erythroderma (HP:0007431)2.44657125
45Pallor (HP:0000980)2.43660799
46Intestinal atresia (HP:0011100)2.42811764
47Abnormality of the renal cortex (HP:0011035)2.32114786
48Abnormality of the anterior horn cell (HP:0006802)2.30875104
49Degeneration of anterior horn cells (HP:0002398)2.30875104
50Gait imbalance (HP:0002141)2.28563522
51Congenital primary aphakia (HP:0007707)2.28500207
52Renal cortical cysts (HP:0000803)2.24893719
53Hypoplasia of the pons (HP:0012110)2.21878202
54Abnormality of the renal medulla (HP:0100957)2.21150518
55Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.20136025
56True hermaphroditism (HP:0010459)2.17852129
57Hypothermia (HP:0002045)2.15342704
58Limb dystonia (HP:0002451)2.15317286
59X-linked dominant inheritance (HP:0001423)2.15074955
60Degeneration of the lateral corticospinal tracts (HP:0002314)2.12924875
61Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.12924875
62Nephrogenic diabetes insipidus (HP:0009806)2.12720815
63Abnormality of placental membranes (HP:0011409)2.12075101
64Amniotic constriction ring (HP:0009775)2.12075101
65Abnormality of the pons (HP:0007361)2.11368769
66Pancreatic fibrosis (HP:0100732)2.08808959
67Patchy hypopigmentation of hair (HP:0011365)2.06382306
68Generalized aminoaciduria (HP:0002909)2.05978222
69Hypoglycemic coma (HP:0001325)2.05509379
70Aplasia/hypoplasia of the uterus (HP:0008684)2.04532640
71Hyperglycinemia (HP:0002154)2.03985740
72Septate vagina (HP:0001153)2.02789250
73Abnormality of secondary sexual hair (HP:0009888)2.01333064
74Abnormality of the axillary hair (HP:0100134)2.01333064
75Lethargy (HP:0001254)2.01141667
76Stenosis of the external auditory canal (HP:0000402)1.99800733
77Congenital, generalized hypertrichosis (HP:0004540)1.99615260
78Colon cancer (HP:0003003)1.97560650
79Adrenal hypoplasia (HP:0000835)1.97044562
80Atrophy/Degeneration involving motor neurons (HP:0007373)1.96533867
81Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.95586596
82Abnormal protein N-linked glycosylation (HP:0012347)1.95586596
83Abnormal protein glycosylation (HP:0012346)1.95586596
84Abnormal glycosylation (HP:0012345)1.95586596
85Genital tract atresia (HP:0001827)1.95466788
86Abnormal ciliary motility (HP:0012262)1.95228007
87Vaginal atresia (HP:0000148)1.93990699
88Sensory axonal neuropathy (HP:0003390)1.93867866
89Hyperphosphaturia (HP:0003109)1.93697668
90Abnormality of the ileum (HP:0001549)1.91288133
91Meckel diverticulum (HP:0002245)1.91188129
92Congenital stationary night blindness (HP:0007642)1.90832428
93Poor suck (HP:0002033)1.89123912
94Gastrointestinal atresia (HP:0002589)1.89035879
95Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.88237418
96Abnormality of alanine metabolism (HP:0010916)1.88237418
97Hyperalaninemia (HP:0003348)1.88237418
98Pancreatic cysts (HP:0001737)1.87727427
99Glycosuria (HP:0003076)1.87283558
100Abnormality of urine glucose concentration (HP:0011016)1.87283558
101Progressive inability to walk (HP:0002505)1.84093870
102Retinal dysplasia (HP:0007973)1.83519024
103Abnormal respiratory motile cilium physiology (HP:0012261)1.83442192
104Volvulus (HP:0002580)1.83403329
105Aplasia/Hypoplasia of the uvula (HP:0010293)1.83304312
106Abnormality of vitamin B metabolism (HP:0004340)1.82386617
107Hyperinsulinemic hypoglycemia (HP:0000825)1.81744043
108Sclerocornea (HP:0000647)1.81108934
109Reduced antithrombin III activity (HP:0001976)1.80124005
110Supernumerary spleens (HP:0009799)1.79907600
111Irregular epiphyses (HP:0010582)1.79541959
112Abnormal respiratory motile cilium morphology (HP:0005938)1.78010954
113Abnormal respiratory epithelium morphology (HP:0012253)1.78010954
114Polyphagia (HP:0002591)1.75110964
115Abnormal hair whorl (HP:0010721)1.74702735
116Aplastic anemia (HP:0001915)1.74481050
117Aplasia/Hypoplasia of the tongue (HP:0010295)1.73453740
118Abnormality of the septum pellucidum (HP:0007375)1.71531021
119Hypoplastic pelvis (HP:0008839)1.70865265
120Abnormality of the corticospinal tract (HP:0002492)1.69753679
121Renal tubular dysfunction (HP:0000124)1.69288856
122Breast hypoplasia (HP:0003187)1.68702872
123Optic nerve hypoplasia (HP:0000609)1.68181076
124Absent septum pellucidum (HP:0001331)1.66737986
125Emotional lability (HP:0000712)1.66351162
126Oligodactyly (hands) (HP:0001180)1.66043813
127Male pseudohermaphroditism (HP:0000037)1.65721980
128Polydipsia (HP:0001959)1.65671563
129Abnormal drinking behavior (HP:0030082)1.65671563
130Focal motor seizures (HP:0011153)1.64239468
131Abnormality of the vitamin B12 metabolism (HP:0004341)1.63591668
132Abnormal urine phosphate concentration (HP:0012599)1.61797647
133Absent/shortened dynein arms (HP:0200106)1.61054583
134Dynein arm defect of respiratory motile cilia (HP:0012255)1.61054583
135Blindness (HP:0000618)1.60121232
136Aplasia/Hypoplasia of the lens (HP:0008063)1.59490698
137Type I transferrin isoform profile (HP:0003642)1.58870785
138Split foot (HP:0001839)1.58145058
139Conical tooth (HP:0000698)1.56948395
140White forelock (HP:0002211)1.56654985
141CNS demyelination (HP:0007305)1.56621498
142Molar tooth sign on MRI (HP:0002419)1.56085677
143Abnormality of midbrain morphology (HP:0002418)1.56085677
144Septo-optic dysplasia (HP:0100842)1.54221397
145Short tibia (HP:0005736)1.54210058
146Myokymia (HP:0002411)1.53711978
147Aplasia/Hypoplasia of the tibia (HP:0005772)1.53706636
148Hypoplasia of the uterus (HP:0000013)1.52399806

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.25975320
2STK163.21111825
3PBK3.05423265
4NME12.88286639
5ARAF2.84522266
6TRIM282.81728238
7MAP4K22.59560616
8STK392.50492188
9BUB12.43350125
10NME22.35964797
11WNK32.25152958
12BCR2.18520171
13FRK2.13381400
14TLK12.07219715
15PINK12.00585213
16MUSK1.99357561
17MST41.95470372
18NEK11.92914425
19OXSR11.90543026
20VRK11.86969450
21VRK21.83928156
22PIM21.75609657
23MAPKAPK51.72495318
24NUAK11.69077888
25ERBB31.65700599
26MKNK11.63459112
27EIF2AK11.63352312
28ADRBK21.61677239
29BRAF1.60799691
30MAP3K121.57851817
31BMPR1B1.57405320
32PNCK1.56432475
33TNIK1.55776226
34MAP3K41.54876282
35BMPR21.54795775
36DYRK21.50867993
37LIMK11.46001701
38SRPK11.43851230
39PLK41.43224201
40GRK71.36823262
41CSNK1G21.35806952
42CDC71.33907757
43CDK191.31021906
44BCKDK1.31000379
45IRAK21.26153371
46GRK51.18368151
47IRAK41.18185937
48EIF2AK31.15334423
49WNK41.12389143
50MAPK131.12089695
51PLK21.11087807
52PDK21.10932809
53MKNK21.06812553
54MYLK0.98942786
55MOS0.98141270
56BRSK20.96676117
57PRKCG0.94298391
58PAK30.93464313
59INSRR0.89357399
60CSNK1A1L0.88170348
61MAP2K70.86456003
62PKN10.85510245
63PASK0.82868580
64CAMK2B0.81672916
65MINK10.80754299
66RPS6KA50.80088586
67CDK80.78867943
68CDK30.77272260
69IRAK10.77062919
70AURKA0.76914202
71ADRBK10.76588215
72DYRK30.76452079
73PLK30.75874160
74ABL20.74822268
75RAF10.74524170
76UHMK10.72869810
77CSNK1G30.72482033
78NEK60.70755923
79CAMK2A0.70356501
80WEE10.69763023
81GRK10.68787948
82OBSCN0.68367950
83EIF2AK20.67217806
84CAMKK20.67127458
85PAK10.65550745
86TTK0.64699491
87TESK20.62767609
88TSSK60.62731395
89RPS6KA40.62260368
90STK30.61468999
91CAMK2D0.61350173
92CCNB10.61330661
93TESK10.59945295
94ROCK20.58899027
95SIK30.55353203
96YES10.54969397
97CSNK1A10.54937432
98FGR0.53395675
99CAMK2G0.53193195
100DAPK20.53119750
101ZAK0.52580798
102FGFR20.52447621
103CSNK2A10.52372089
104PLK10.51151924
105NTRK30.50910241
106ACVR1B0.50213496
107ATR0.49674035
108CDK140.48323934
109MAPK150.48257463
110PRKCE0.48145167
111TIE10.47504630
112ERBB40.46774248
113FES0.46728742
114TAF10.46287161
115CSNK1G10.46149155
116CSNK2A20.45534274
117DAPK30.44355312
118PRKG10.43935938
119AKT30.43780750
120PHKG20.42770535
121PHKG10.42770535
122AURKB0.42261431
123ATM0.41383264
124TAOK30.41089230
125TEC0.40582941
126ILK0.40181313
127PRKACA0.39087468
128CSNK1E0.38916112
129EPHA40.38620443
130CDK11A0.38584526
131CDK180.38564970
132TNK20.38481119
133KDR0.37863360
134TXK0.37426956
135PRKCI0.35737431
136MARK10.35139078
137CDK150.35053276
138MST1R0.34059862
139CHEK20.33691704
140PRKACB0.33053820
141BRSK10.32662586
142STK38L0.32149430

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.39666120
2Ribosome_Homo sapiens_hsa030104.80134487
3Parkinsons disease_Homo sapiens_hsa050124.54137262
4Proteasome_Homo sapiens_hsa030503.58753789
5Alzheimers disease_Homo sapiens_hsa050103.48792596
6Huntingtons disease_Homo sapiens_hsa050163.43643607
7RNA polymerase_Homo sapiens_hsa030203.17856238
8Protein export_Homo sapiens_hsa030602.98895575
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.78019594
10Cardiac muscle contraction_Homo sapiens_hsa042601.94707418
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.87789193
12Propanoate metabolism_Homo sapiens_hsa006401.68793248
13Homologous recombination_Homo sapiens_hsa034401.67481009
14Basal transcription factors_Homo sapiens_hsa030221.65962040
15Pyrimidine metabolism_Homo sapiens_hsa002401.59997996
16Butanoate metabolism_Homo sapiens_hsa006501.55856874
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.55612994
18Collecting duct acid secretion_Homo sapiens_hsa049661.54223551
19Phototransduction_Homo sapiens_hsa047441.51803896
20* Spliceosome_Homo sapiens_hsa030401.47945312
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.43645657
22Ether lipid metabolism_Homo sapiens_hsa005651.43599808
23Mismatch repair_Homo sapiens_hsa034301.37011363
24Nucleotide excision repair_Homo sapiens_hsa034201.36996482
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.34758559
26Linoleic acid metabolism_Homo sapiens_hsa005911.29867210
27DNA replication_Homo sapiens_hsa030301.28819197
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.22502317
29Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.19669166
30Arachidonic acid metabolism_Homo sapiens_hsa005901.16747098
31Rheumatoid arthritis_Homo sapiens_hsa053231.15768575
32Fatty acid elongation_Homo sapiens_hsa000621.15559598
33Steroid biosynthesis_Homo sapiens_hsa001001.15162079
34RNA degradation_Homo sapiens_hsa030181.13403061
35Purine metabolism_Homo sapiens_hsa002301.12436450
36Fanconi anemia pathway_Homo sapiens_hsa034601.10842458
37SNARE interactions in vesicular transport_Homo sapiens_hsa041301.09902979
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.08495747
39One carbon pool by folate_Homo sapiens_hsa006701.06820725
40Nitrogen metabolism_Homo sapiens_hsa009101.04046581
41Vibrio cholerae infection_Homo sapiens_hsa051101.02753088
42Selenocompound metabolism_Homo sapiens_hsa004501.01785251
43Peroxisome_Homo sapiens_hsa041460.98292911
44Non-homologous end-joining_Homo sapiens_hsa034500.98273362
45Caffeine metabolism_Homo sapiens_hsa002320.97298976
46Serotonergic synapse_Homo sapiens_hsa047260.96788323
47alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.95277666
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.95160524
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.91751131
50Sphingolipid metabolism_Homo sapiens_hsa006000.91150065
51Sulfur metabolism_Homo sapiens_hsa009200.89667482
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86915160
53Base excision repair_Homo sapiens_hsa034100.84287259
54Autoimmune thyroid disease_Homo sapiens_hsa053200.81016063
55RNA transport_Homo sapiens_hsa030130.78919073
56Graft-versus-host disease_Homo sapiens_hsa053320.76157743
57Pyruvate metabolism_Homo sapiens_hsa006200.74637652
58Nicotine addiction_Homo sapiens_hsa050330.74479581
59Glutathione metabolism_Homo sapiens_hsa004800.72448753
60Tryptophan metabolism_Homo sapiens_hsa003800.72204360
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.71986047
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.70625943
63Allograft rejection_Homo sapiens_hsa053300.68526807
64Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.67808249
65Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.67598046
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63033833
67Metabolic pathways_Homo sapiens_hsa011000.61349358
68Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.60424513
69Chemical carcinogenesis_Homo sapiens_hsa052040.59577374
70Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55299356
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55270303
72Taste transduction_Homo sapiens_hsa047420.54783033
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.54386377
74Insulin secretion_Homo sapiens_hsa049110.53692430
75Asthma_Homo sapiens_hsa053100.53490083
76Alcoholism_Homo sapiens_hsa050340.51846272
77beta-Alanine metabolism_Homo sapiens_hsa004100.50013707
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49690373
79Cell cycle_Homo sapiens_hsa041100.49229054
80Systemic lupus erythematosus_Homo sapiens_hsa053220.48328762
81Long-term depression_Homo sapiens_hsa047300.47696166
82Regulation of autophagy_Homo sapiens_hsa041400.46456625
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44812214
84Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44485909
85mRNA surveillance pathway_Homo sapiens_hsa030150.43971520
86Phagosome_Homo sapiens_hsa041450.43886469
87Glutamatergic synapse_Homo sapiens_hsa047240.41397043
88Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.41035978
89Epstein-Barr virus infection_Homo sapiens_hsa051690.40494469
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40221691
91Synaptic vesicle cycle_Homo sapiens_hsa047210.39500411
92Amphetamine addiction_Homo sapiens_hsa050310.39249686
93N-Glycan biosynthesis_Homo sapiens_hsa005100.38395354
94Fatty acid metabolism_Homo sapiens_hsa012120.37905605
95Type I diabetes mellitus_Homo sapiens_hsa049400.37322557
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36871496
97Circadian rhythm_Homo sapiens_hsa047100.36774768
98Malaria_Homo sapiens_hsa051440.36686491
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35963927
100Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35303744
101Morphine addiction_Homo sapiens_hsa050320.35049707
102Fatty acid degradation_Homo sapiens_hsa000710.33593665
103Retinol metabolism_Homo sapiens_hsa008300.33003963
104Intestinal immune network for IgA production_Homo sapiens_hsa046720.31892841
105Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.31091756
106GABAergic synapse_Homo sapiens_hsa047270.30801141
107Cocaine addiction_Homo sapiens_hsa050300.29700120
108Axon guidance_Homo sapiens_hsa043600.28706702
109African trypanosomiasis_Homo sapiens_hsa051430.28354898
110Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.27939230
111Other glycan degradation_Homo sapiens_hsa005110.24668800
112Ovarian steroidogenesis_Homo sapiens_hsa049130.23694203
113Vitamin B6 metabolism_Homo sapiens_hsa007500.23452055
114Oocyte meiosis_Homo sapiens_hsa041140.22828754
115Ras signaling pathway_Homo sapiens_hsa040140.22256209
116Steroid hormone biosynthesis_Homo sapiens_hsa001400.21298210
117Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.20701223
118Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.20139790
119Hedgehog signaling pathway_Homo sapiens_hsa043400.19859163
120NOD-like receptor signaling pathway_Homo sapiens_hsa046210.19666725
121Vascular smooth muscle contraction_Homo sapiens_hsa042700.18356962
122Dopaminergic synapse_Homo sapiens_hsa047280.16764292
123Tyrosine metabolism_Homo sapiens_hsa003500.16087466
124Mineral absorption_Homo sapiens_hsa049780.14370467
125Circadian entrainment_Homo sapiens_hsa047130.14153999
126Calcium signaling pathway_Homo sapiens_hsa040200.14083607
127Arginine and proline metabolism_Homo sapiens_hsa003300.12986125
128Folate biosynthesis_Homo sapiens_hsa007900.12421249
129p53 signaling pathway_Homo sapiens_hsa041150.11674914
130Primary immunodeficiency_Homo sapiens_hsa053400.11363332
131Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.11175641
132Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.10541331
133Hematopoietic cell lineage_Homo sapiens_hsa046400.10217667
134Olfactory transduction_Homo sapiens_hsa047400.08497982

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