SNRNP35

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a homolog of the U1-snRNP binding protein. The N-terminal half contains a RNA recognition motif and the C-terminal half is rich in Arg/Asp and Arg/Glu dipeptides, which is a characteristic of a variety of splicing factors. This protein is a component of the U11/U12 small nuclear ribonucleoproteins (snRNP) that form part of the U12-type spliceosome. Alternative splicing results in multiple transcript variants encoding two distinct isoforms and representing a non-protein coding variant. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.22741013
2ATP synthesis coupled proton transport (GO:0015986)4.83744683
3energy coupled proton transport, down electrochemical gradient (GO:0015985)4.83744683
4protein localization to kinetochore (GO:0034501)4.52064679
5mitotic metaphase plate congression (GO:0007080)4.49617109
6protein complex biogenesis (GO:0070271)4.44310238
7mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.43712658
8microtubule depolymerization (GO:0007019)4.31938887
9protein localization to chromosome, centromeric region (GO:0071459)4.29215607
10mitochondrial respiratory chain complex assembly (GO:0033108)4.14269153
11mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.09628219
12mitochondrial respiratory chain complex I assembly (GO:0032981)4.09628219
13NADH dehydrogenase complex assembly (GO:0010257)4.09628219
14mitotic sister chromatid segregation (GO:0000070)4.06592928
15regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.97236960
16electron transport chain (GO:0022900)3.92824409
17respiratory chain complex IV assembly (GO:0008535)3.88746461
18respiratory electron transport chain (GO:0022904)3.86636836
19spliceosomal snRNP assembly (GO:0000387)3.81789748
20regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.81492205
21cytochrome complex assembly (GO:0017004)3.79199471
22DNA deamination (GO:0045006)3.78838602
23proteasome assembly (GO:0043248)3.75577025
24L-fucose metabolic process (GO:0042354)3.72606500
25L-fucose catabolic process (GO:0042355)3.72606500
26fucose catabolic process (GO:0019317)3.72606500
27protein-cofactor linkage (GO:0018065)3.63974577
28purine nucleobase biosynthetic process (GO:0009113)3.54806338
29water-soluble vitamin biosynthetic process (GO:0042364)3.52338737
30piRNA metabolic process (GO:0034587)3.51729172
31regulation of exit from mitosis (GO:0007096)3.51309779
32DNA replication checkpoint (GO:0000076)3.50384094
33sister chromatid segregation (GO:0000819)3.48669553
34platelet dense granule organization (GO:0060155)3.43587629
35epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.37701045
36viral transcription (GO:0019083)3.37595408
37regulation of cilium movement (GO:0003352)3.35272390
38metaphase plate congression (GO:0051310)3.35205307
39negative regulation of telomere maintenance (GO:0032205)3.32521055
40DNA replication-dependent nucleosome organization (GO:0034723)3.30648471
41DNA replication-dependent nucleosome assembly (GO:0006335)3.30648471
42translational termination (GO:0006415)3.28440653
43DNA strand elongation involved in DNA replication (GO:0006271)3.27913239
44anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.27439042
45negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.20325912
46kinetochore assembly (GO:0051382)3.19772672
47establishment of protein localization to mitochondrial membrane (GO:0090151)3.18621398
48indole-containing compound catabolic process (GO:0042436)3.14654042
49indolalkylamine catabolic process (GO:0046218)3.14654042
50tryptophan catabolic process (GO:0006569)3.14654042
51RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.14342802
52tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.14342802
53nucleobase biosynthetic process (GO:0046112)3.13974153
54ribosome biogenesis (GO:0042254)3.13531549
55kinetochore organization (GO:0051383)3.13207810
56indolalkylamine metabolic process (GO:0006586)3.12394659
57kynurenine metabolic process (GO:0070189)3.10631114
58regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.10534456
59microtubule polymerization or depolymerization (GO:0031109)3.05323130
60regulation of spindle checkpoint (GO:0090231)3.05178429
61positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.04082991
62hydrogen ion transmembrane transport (GO:1902600)3.03678298
63mitotic chromosome condensation (GO:0007076)3.03448678
647-methylguanosine mRNA capping (GO:0006370)3.03110486
65ubiquinone biosynthetic process (GO:0006744)3.02793829
66establishment of chromosome localization (GO:0051303)3.02720473
67negative regulation of ligase activity (GO:0051352)3.02279218
68negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.02279218
69transcription elongation from RNA polymerase III promoter (GO:0006385)3.02247538
70termination of RNA polymerase III transcription (GO:0006386)3.02247538
71synaptonemal complex assembly (GO:0007130)3.02074452
72DNA replication initiation (GO:0006270)2.99634062
73ATP biosynthetic process (GO:0006754)2.99560170
74DNA strand elongation (GO:0022616)2.99510932
75attachment of spindle microtubules to kinetochore (GO:0008608)2.98749744
76histone exchange (GO:0043486)2.97239623
77telomere maintenance via semi-conservative replication (GO:0032201)2.97235210
78mannosylation (GO:0097502)2.97137068
79male meiosis (GO:0007140)2.96022561
80epithelial cilium movement (GO:0003351)2.94842463
81proton transport (GO:0015992)2.93020676
82ribosome assembly (GO:0042255)2.92297969
83detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.91234459
84synaptonemal complex organization (GO:0070193)2.90759460
85RNA capping (GO:0036260)2.89982341
867-methylguanosine RNA capping (GO:0009452)2.89982341
87intracellular protein transmembrane import (GO:0044743)2.89329349
88chromosome segregation (GO:0007059)2.88484215
89spliceosomal complex assembly (GO:0000245)2.87668776
90positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.86548550
91hydrogen transport (GO:0006818)2.86094667
92maturation of 5.8S rRNA (GO:0000460)2.85899792
93pseudouridine synthesis (GO:0001522)2.85044136
94nonmotile primary cilium assembly (GO:0035058)2.84991654
95amino acid salvage (GO:0043102)2.84930540
96L-methionine salvage (GO:0071267)2.84930540
97L-methionine biosynthetic process (GO:0071265)2.84930540
98cotranslational protein targeting to membrane (GO:0006613)2.82113925
99adaptation of signaling pathway (GO:0023058)2.81847810
100SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.81844977
101establishment of integrated proviral latency (GO:0075713)2.81009052
102telomere maintenance via recombination (GO:0000722)2.79871177
103purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.79558310
104translational elongation (GO:0006414)2.79337975
105mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.77896233
106purine nucleoside triphosphate biosynthetic process (GO:0009145)2.77884349
107regulation of chromosome segregation (GO:0051983)2.77283948
108protein targeting to ER (GO:0045047)2.76972643
109ribosomal small subunit biogenesis (GO:0042274)2.74322831
110ubiquinone metabolic process (GO:0006743)2.74114072
111protein polyglutamylation (GO:0018095)2.73069622
112preassembly of GPI anchor in ER membrane (GO:0016254)2.71724224
113chromosome condensation (GO:0030261)2.71709904
114positive regulation of ligase activity (GO:0051351)2.71691254
115IMP biosynthetic process (GO:0006188)2.71617965
116dopamine transport (GO:0015872)2.71009917
117DNA unwinding involved in DNA replication (GO:0006268)2.70496924
118CENP-A containing nucleosome assembly (GO:0034080)2.70271079
119antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.69743541
120regulation of ubiquitin-protein transferase activity (GO:0051438)2.69589720
121cellular biogenic amine catabolic process (GO:0042402)2.68419260
122amine catabolic process (GO:0009310)2.68419260
123IMP metabolic process (GO:0046040)2.68205882
124chaperone-mediated protein transport (GO:0072321)2.68137021
125positive regulation of defense response to virus by host (GO:0002230)2.67748765
126antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.67545176
127regulation of microtubule-based movement (GO:0060632)2.66623154
128regulation of mitochondrial translation (GO:0070129)2.65997990
129cellular ketone body metabolic process (GO:0046950)2.65819377
130meiotic cell cycle (GO:0051321)2.65738439
131male meiosis I (GO:0007141)2.65579892
132ribonucleoprotein complex biogenesis (GO:0022613)2.65311873
133axoneme assembly (GO:0035082)2.65094729
134DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.64876362
135positive regulation of viral transcription (GO:0050434)2.64194465
136protein neddylation (GO:0045116)2.63827518
137establishment of protein localization to endoplasmic reticulum (GO:0072599)2.63682331
138sulfation (GO:0051923)2.63661297
139rRNA processing (GO:0006364)2.63517000
140chromatin remodeling at centromere (GO:0031055)2.63298045
141deoxyribose phosphate biosynthetic process (GO:0046385)2.63261529
1422-deoxyribonucleotide biosynthetic process (GO:0009265)2.63261529
143formation of translation preinitiation complex (GO:0001731)2.63056674
144nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.63017398
145transcription elongation from RNA polymerase II promoter (GO:0006368)2.62862210
146maturation of SSU-rRNA (GO:0030490)2.62694424
147synaptic transmission, cholinergic (GO:0007271)2.62692663
148protein localization to endoplasmic reticulum (GO:0070972)2.61826068
149blastocyst development (GO:0001824)2.61284974
150positive regulation of chromosome segregation (GO:0051984)2.61163657
151rRNA metabolic process (GO:0016072)2.60837205
152protein localization to cilium (GO:0061512)2.60759342
153spindle checkpoint (GO:0031577)2.60616878
154RNA splicing, via transesterification reactions (GO:0000375)2.59859589
155mitotic recombination (GO:0006312)2.59380663
156establishment of protein localization to mitochondrion (GO:0072655)2.59018769
157signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.58878806
158intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.58878806
159meiotic nuclear division (GO:0007126)2.58550799
160mRNA splicing, via spliceosome (GO:0000398)2.58205286
161RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.58205286
162regulation of centrosome cycle (GO:0046605)2.57890938
163tryptophan metabolic process (GO:0006568)2.57868401
164regulation of ligase activity (GO:0051340)2.57774979
165DNA replication-independent nucleosome organization (GO:0034724)2.57049558
166DNA replication-independent nucleosome assembly (GO:0006336)2.57049558
167sperm-egg recognition (GO:0035036)2.56528696
168mitotic nuclear envelope disassembly (GO:0007077)2.56452364
169response to pheromone (GO:0019236)2.56328194
170regulation of cellular amino acid metabolic process (GO:0006521)2.54669821
171binding of sperm to zona pellucida (GO:0007339)2.54519826
172exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.54228009
173negative regulation of transcription regulatory region DNA binding (GO:2000678)2.54045041
174tRNA processing (GO:0008033)2.52543516
175detection of light stimulus involved in visual perception (GO:0050908)2.51868597
176detection of light stimulus involved in sensory perception (GO:0050962)2.51868597
177negative regulation of response to food (GO:0032096)2.48992428
178negative regulation of appetite (GO:0032099)2.48992428
179pyrimidine nucleobase catabolic process (GO:0006208)2.48807948
180parturition (GO:0007567)2.46621640
181indole-containing compound metabolic process (GO:0042430)2.42918653
182nucleotide transmembrane transport (GO:1901679)2.41737687
183cell proliferation in forebrain (GO:0021846)2.41369339
184viral life cycle (GO:0019058)2.41337657
185transmission of nerve impulse (GO:0019226)2.40964314
186cellular protein complex disassembly (GO:0043624)2.40100312
187ketone body metabolic process (GO:1902224)2.37809416
188retinal ganglion cell axon guidance (GO:0031290)2.36570718
189negative regulation of mast cell activation (GO:0033004)2.34788105
190ribosomal small subunit assembly (GO:0000028)2.34037673
191cilium morphogenesis (GO:0060271)2.32621141

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.09581410
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.18103601
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.03064831
4ZNF274_21170338_ChIP-Seq_K562_Hela3.93470804
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.42357858
6EZH2_22144423_ChIP-Seq_EOC_Human3.31409420
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.30317706
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.29985753
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.23783274
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.21741493
11E2F4_17652178_ChIP-ChIP_JURKAT_Human3.06451834
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.99672708
13VDR_22108803_ChIP-Seq_LS180_Human2.94072959
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.90110032
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.84294259
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.81785378
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.81117546
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.76647126
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.76082453
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.59132743
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.45598270
22MYC_19030024_ChIP-ChIP_MESCs_Mouse2.41227562
23* VDR_23849224_ChIP-Seq_CD4+_Human2.27007568
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.22922440
25XRN2_22483619_ChIP-Seq_HELA_Human2.21269724
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.20386772
27MYC_19079543_ChIP-ChIP_MESCs_Mouse2.14541480
28NELFA_20434984_ChIP-Seq_ESCs_Mouse2.11099859
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.10649566
30DCP1A_22483619_ChIP-Seq_HELA_Human1.99216449
31* YY1_21170310_ChIP-Seq_MESCs_Mouse1.95986828
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.91774612
33GABP_19822575_ChIP-Seq_HepG2_Human1.91417947
34EWS_26573619_Chip-Seq_HEK293_Human1.89199357
35HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.88517524
36IGF1R_20145208_ChIP-Seq_DFB_Human1.86487055
37AR_21909140_ChIP-Seq_LNCAP_Human1.82892847
38* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.81822283
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.79407494
40GBX2_23144817_ChIP-Seq_PC3_Human1.78866823
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.77239165
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.76209675
43RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74581677
44TP53_22573176_ChIP-Seq_HFKS_Human1.72947279
45GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.72783466
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.72307230
47FOXP3_21729870_ChIP-Seq_TREG_Human1.70839581
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.67717490
49THAP11_20581084_ChIP-Seq_MESCs_Mouse1.67673628
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.67358354
51MYCN_18555785_ChIP-Seq_MESCs_Mouse1.67305138
52E2F1_18555785_ChIP-Seq_MESCs_Mouse1.67133903
53NOTCH1_21737748_ChIP-Seq_TLL_Human1.66557230
54CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66130540
55HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.65786942
56MYC_18940864_ChIP-ChIP_HL60_Human1.62301109
57TTF2_22483619_ChIP-Seq_HELA_Human1.57785336
58SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.57129313
59IRF1_19129219_ChIP-ChIP_H3396_Human1.56807937
60CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.56322396
61ELK1_19687146_ChIP-ChIP_HELA_Human1.55650299
62REST_21632747_ChIP-Seq_MESCs_Mouse1.55219031
63MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.53613836
64KDM5A_27292631_Chip-Seq_BREAST_Human1.50474039
65BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.50237125
66SRF_21415370_ChIP-Seq_HL-1_Mouse1.49845203
67MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49501258
68TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48611480
69PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.47688504
70FOXA1_25329375_ChIP-Seq_VCAP_Human1.46108649
71FOXA1_27270436_Chip-Seq_PROSTATE_Human1.46108649
72CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.45818440
73ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.45481175
74E2F1_21310950_ChIP-Seq_MCF-7_Human1.44535020
75SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.43301023
76IRF8_21731497_ChIP-ChIP_J774_Mouse1.42315884
77* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.41171578
78ELF1_17652178_ChIP-ChIP_JURKAT_Human1.41091843
79FUS_26573619_Chip-Seq_HEK293_Human1.39290078
80* GATA3_21878914_ChIP-Seq_MCF-7_Human1.38891576
81POU3F2_20337985_ChIP-ChIP_501MEL_Human1.37756786
82ETV2_25802403_ChIP-Seq_MESCs_Mouse1.36521576
83P300_19829295_ChIP-Seq_ESCs_Human1.35851871
84HOXB4_20404135_ChIP-ChIP_EML_Mouse1.35425366
85TAF15_26573619_Chip-Seq_HEK293_Human1.33951672
86FLI1_27457419_Chip-Seq_LIVER_Mouse1.33363275
87* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.32875350
88* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.30991621
89CIITA_25753668_ChIP-Seq_RAJI_Human1.29185008
90ER_23166858_ChIP-Seq_MCF-7_Human1.28714408
91MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.27669216
92CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.27460894
93* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26801155
94NANOG_18555785_ChIP-Seq_MESCs_Mouse1.26217275
95DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.26005360
96ERA_21632823_ChIP-Seq_H3396_Human1.25990052
97EZH2_27304074_Chip-Seq_ESCs_Mouse1.25674239
98CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.25004578
99RNF2_27304074_Chip-Seq_NSC_Mouse1.24507113
100KLF4_18555785_ChIP-Seq_MESCs_Mouse1.24294645
101ZFX_18555785_ChIP-Seq_MESCs_Mouse1.24191050
102AR_20517297_ChIP-Seq_VCAP_Human1.22374835
103PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22069540
104GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21214702
105MYC_22102868_ChIP-Seq_BL_Human1.21173079
106NCOR_22424771_ChIP-Seq_293T_Human1.21004766
107SOX2_19829295_ChIP-Seq_ESCs_Human1.20707972
108NANOG_19829295_ChIP-Seq_ESCs_Human1.20707972
109TAF2_19829295_ChIP-Seq_ESCs_Human1.20047505
110E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19862538
111FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.19473355
112TFEB_21752829_ChIP-Seq_HELA_Human1.19240599
113EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.18364456
114UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18125529
115PADI4_21655091_ChIP-ChIP_MCF-7_Human1.18082374
116REST_18959480_ChIP-ChIP_MESCs_Mouse1.17966027
117MYC_19829295_ChIP-Seq_ESCs_Human1.17891543
118NANOG_20526341_ChIP-Seq_ESCs_Human1.17263299
119ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17243047
120CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.16512820
121LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.15746150
122EED_16625203_ChIP-ChIP_MESCs_Mouse1.14481218
123AR_25329375_ChIP-Seq_VCAP_Human1.13337266
124JARID2_20064375_ChIP-Seq_MESCs_Mouse1.11942759
125SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11178674
126BCAT_22108803_ChIP-Seq_LS180_Human1.11137790
127FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.10431470
128PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08079736
129VDR_21846776_ChIP-Seq_THP-1_Human1.07089677
130EZH2_27294783_Chip-Seq_ESCs_Mouse1.06375324
131POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06136863
132TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06136863
133PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03666634
134POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03349613
135CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.03220137
136HOXB7_26014856_ChIP-Seq_BT474_Human1.03215291
137BP1_19119308_ChIP-ChIP_Hs578T_Human1.01391370
138P53_21459846_ChIP-Seq_SAOS-2_Human1.01367679
139SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.00362083
140CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.00043890
141EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.98908904
142FOXA1_21572438_ChIP-Seq_LNCaP_Human0.98464760
143FOXH1_21741376_ChIP-Seq_EPCs_Human0.96256454
144CBP_20019798_ChIP-Seq_JUKART_Human0.96240049
145IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96240049
146* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.96151720
147EGR1_19374776_ChIP-ChIP_THP-1_Human0.95301171
148* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.95204131
149JARID2_20075857_ChIP-Seq_MESCs_Mouse0.94682857
150CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.94528292
151CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.93617218
152MYB_21317192_ChIP-Seq_ERMYB_Mouse0.93381227
153* SPI1_23547873_ChIP-Seq_NB4_Human0.93085622
154KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.92119167
155SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.91626058
156SUZ12_27294783_Chip-Seq_ESCs_Mouse0.91312696
157ELK1_22589737_ChIP-Seq_MCF10A_Human0.91063860
158TCF4_22108803_ChIP-Seq_LS180_Human0.91009566
159STAT3_1855785_ChIP-Seq_MESCs_Mouse0.90536993
160FOXH1_21741376_ChIP-Seq_ESCs_Human0.88723303
161NR3C1_21868756_ChIP-Seq_MCF10A_Human0.88668054
162AUTS2_25519132_ChIP-Seq_293T-REX_Human0.87383754
163CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87027773
164EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.86476728
165TBX5_21415370_ChIP-Seq_HL-1_Mouse0.84734884
166MAF_26560356_Chip-Seq_TH2_Human0.84185577
167NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.84029490
168NANOG_21062744_ChIP-ChIP_HESCs_Human0.79735377
169POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.79391938
170IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.79065221
171* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78882800
172GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.78730083
173FOXP1_21924763_ChIP-Seq_HESCs_Human0.78230489
174YY1_22570637_ChIP-Seq_MALME-3M_Human0.76252775
175BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.75642295
176HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.75604352
177PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.75560431
178GATA1_22383799_ChIP-Seq_G1ME_Mouse0.75481049
179* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.74835024

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.40723754
2MP0003111_abnormal_nucleus_morphology3.83334483
3MP0004957_abnormal_blastocyst_morpholog3.56141201
4MP0008057_abnormal_DNA_replication3.25378850
5MP0010094_abnormal_chromosome_stability3.19415373
6MP0003077_abnormal_cell_cycle3.18690868
7MP0005410_abnormal_fertilization2.95361493
8MP0003656_abnormal_erythrocyte_physiolo2.86685266
9MP0003646_muscle_fatigue2.82573975
10MP0002653_abnormal_ependyma_morphology2.63809196
11MP0003303_peritoneal_inflammation2.57106838
12MP0002837_dystrophic_cardiac_calcinosis2.55693629
13MP0003195_calcinosis2.39481818
14MP0004142_abnormal_muscle_tone2.27534784
15MP0002638_abnormal_pupillary_reflex2.14613505
16MP0001730_embryonic_growth_arrest2.10840917
17MP0008877_abnormal_DNA_methylation2.10335117
18MP0005551_abnormal_eye_electrophysiolog2.09367139
19MP0006292_abnormal_olfactory_placode2.06930984
20MP0003880_abnormal_central_pattern2.04289038
21MP0002102_abnormal_ear_morphology1.99891822
22MP0009046_muscle_twitch1.98130551
23MP0001968_abnormal_touch/_nociception1.97711502
24MP0008932_abnormal_embryonic_tissue1.96503351
25MP0006036_abnormal_mitochondrial_physio1.92393020
26MP0000350_abnormal_cell_proliferation1.87249969
27MP0002876_abnormal_thyroid_physiology1.87174347
28MP0008058_abnormal_DNA_repair1.84506621
29MP0001529_abnormal_vocalization1.83841114
30MP0003221_abnormal_cardiomyocyte_apopto1.83655027
31MP0005646_abnormal_pituitary_gland1.81121190
32MP0009745_abnormal_behavioral_response1.80806461
33MP0004043_abnormal_pH_regulation1.80327782
34MP0005645_abnormal_hypothalamus_physiol1.79772240
35MP0001727_abnormal_embryo_implantation1.79661989
36MP0003011_delayed_dark_adaptation1.78696970
37MP0008260_abnormal_autophagy1.78494847
38MP0000750_abnormal_muscle_regeneration1.77183770
39MP0004885_abnormal_endolymph1.76361353
40MP0001485_abnormal_pinna_reflex1.76220873
41MP0001929_abnormal_gametogenesis1.75970184
42MP0006072_abnormal_retinal_apoptosis1.75389304
43MP0010307_abnormal_tumor_latency1.75125121
44MP0004147_increased_porphyrin_level1.72636145
45MP0008872_abnormal_physiological_respon1.72461237
46MP0002272_abnormal_nervous_system1.71500729
47MP0000372_irregular_coat_pigmentation1.69956564
48MP0001986_abnormal_taste_sensitivity1.69683927
49MP0008875_abnormal_xenobiotic_pharmacok1.68942919
50MP0000631_abnormal_neuroendocrine_gland1.66320052
51MP0003787_abnormal_imprinting1.60683677
52MP0002736_abnormal_nociception_after1.60491151
53MP0002210_abnormal_sex_determination1.59981531
54MP0004145_abnormal_muscle_electrophysio1.58880051
55MP0008007_abnormal_cellular_replicative1.58255288
56MP0003436_decreased_susceptibility_to1.50781296
57MP0009840_abnormal_foam_cell1.49997166
58MP0005084_abnormal_gallbladder_morpholo1.46689116
59MP0002396_abnormal_hematopoietic_system1.45946585
60MP0005058_abnormal_lysosome_morphology1.44868016
61MP0002277_abnormal_respiratory_mucosa1.44822205
62MP0001905_abnormal_dopamine_level1.44354219
63MP0001672_abnormal_embryogenesis/_devel1.43385615
64MP0005380_embryogenesis_phenotype1.43385615
65MP0004133_heterotaxia1.43287619
66MP0000747_muscle_weakness1.42999380
67MP0003698_abnormal_male_reproductive1.42667038
68MP0009333_abnormal_splenocyte_physiolog1.42600454
69MP0005253_abnormal_eye_physiology1.42217460
70MP0003123_paternal_imprinting1.41719331
71MP0000749_muscle_degeneration1.41508102
72MP0003984_embryonic_growth_retardation1.40754688
73MP0001697_abnormal_embryo_size1.38850501
74MP0001984_abnormal_olfaction1.37731748
75MP0003950_abnormal_plasma_membrane1.36621559
76MP0003806_abnormal_nucleotide_metabolis1.35831420
77MP0009379_abnormal_foot_pigmentation1.35814598
78MP0002088_abnormal_embryonic_growth/wei1.34960646
79MP0004742_abnormal_vestibular_system1.32840307
80MP0002064_seizures1.32605340
81MP0000313_abnormal_cell_death1.31196904
82MP0000427_abnormal_hair_cycle1.31005251
83MP0006276_abnormal_autonomic_nervous1.30417482
84MP0003718_maternal_effect1.28720870
85MP0005389_reproductive_system_phenotype1.28617508
86MP0002938_white_spotting1.27839250
87MP0002080_prenatal_lethality1.27371621
88MP0002163_abnormal_gland_morphology1.27259440
89MP0001145_abnormal_male_reproductive1.26927619
90MP0002160_abnormal_reproductive_system1.23362106
91MP0005379_endocrine/exocrine_gland_phen1.22566956
92MP0001501_abnormal_sleep_pattern1.22318251
93MP0001970_abnormal_pain_threshold1.19146003
94MP0002733_abnormal_thermal_nociception1.18601574
95MP0000358_abnormal_cell_content/1.17736738
96MP0010386_abnormal_urinary_bladder1.17426452
97MP0002572_abnormal_emotion/affect_behav1.15831750
98MP0002019_abnormal_tumor_incidence1.14897914
99MP0001919_abnormal_reproductive_system1.12998938
100MP0003136_yellow_coat_color1.10499919
101MP0002557_abnormal_social/conspecific_i1.09611006
102MP0005000_abnormal_immune_tolerance1.08506678
103MP0001545_abnormal_hematopoietic_system1.07670942
104MP0005397_hematopoietic_system_phenotyp1.07670942
105MP0002095_abnormal_skin_pigmentation1.07370370
106MP0004808_abnormal_hematopoietic_stem1.06847732
107MP0002067_abnormal_sensory_capabilities1.06394578
108MP0006082_CNS_inflammation1.05905817
109MP0005076_abnormal_cell_differentiation1.05421946
110MP0005195_abnormal_posterior_eye1.05204757
111MP0000689_abnormal_spleen_morphology1.05115725
112MP0001486_abnormal_startle_reflex1.04671339
113MP0006035_abnormal_mitochondrial_morpho1.03533467
114MP0000653_abnormal_sex_gland1.03240436
115MP0002419_abnormal_innate_immunity1.02890193
116MP0002398_abnormal_bone_marrow1.02757866
117MP0001764_abnormal_homeostasis1.02647521
118MP0002735_abnormal_chemical_nociception1.01516580
119MP0004084_abnormal_cardiac_muscle1.00799327
120MP0004510_myositis1.00549718
121MP0005451_abnormal_body_composition0.99225870
122MP0002161_abnormal_fertility/fecundity0.99074011
123MP0002269_muscular_atrophy0.98700832
124MP0002234_abnormal_pharynx_morphology0.98296811
125MP0002138_abnormal_hepatobiliary_system0.98011113
126MP0002722_abnormal_immune_system0.97910920
127MP0002085_abnormal_embryonic_tissue0.97168419
128MP0005671_abnormal_response_to0.97146391
129MP0008789_abnormal_olfactory_epithelium0.97111607
130MP0005377_hearing/vestibular/ear_phenot0.97028678
131MP0003878_abnormal_ear_physiology0.97028678
132MP0002254_reproductive_system_inflammat0.96872287
133MP0002106_abnormal_muscle_physiology0.96339310
134MP0001849_ear_inflammation0.95698587
135MP0008995_early_reproductive_senescence0.95503675
136MP0004197_abnormal_fetal_growth/weight/0.94492105
137MP0004185_abnormal_adipocyte_glucose0.94269374
138MP0003121_genomic_imprinting0.94068976
139MP0009672_abnormal_birth_weight0.93560224
140MP0005257_abnormal_intraocular_pressure0.93252377
141MP0000778_abnormal_nervous_system0.92720542
142MP0002452_abnormal_antigen_presenting0.92277816
143MP0000026_abnormal_inner_ear0.91807572
144MP0002752_abnormal_somatic_nervous0.90767966
145MP0002429_abnormal_blood_cell0.89242064
146MP0002723_abnormal_immune_serum0.88961058
147MP0000230_abnormal_systemic_arterial0.87790522
148MP0003186_abnormal_redox_activity0.87696317
149MP0009785_altered_susceptibility_to0.87598599
150MP0002148_abnormal_hypersensitivity_rea0.87414783
151MP0002332_abnormal_exercise_endurance0.87284415
152MP0003283_abnormal_digestive_organ0.87048440
153MP0004924_abnormal_behavior0.85104610
154MP0005386_behavior/neurological_phenoty0.85104610
155MP0003122_maternal_imprinting0.84996332
156MP0000685_abnormal_immune_system0.84950863
157MP0002086_abnormal_extraembryonic_tissu0.84138378
158MP0005025_abnormal_response_to0.83979231
159MP0003635_abnormal_synaptic_transmissio0.83851485
160MP0004215_abnormal_myocardial_fiber0.83669118
161MP0002063_abnormal_learning/memory/cond0.83260329
162MP0001440_abnormal_grooming_behavior0.82610155
163MP0000716_abnormal_immune_system0.81873541
164MP0003137_abnormal_impulse_conducting0.81244602
165MP0001800_abnormal_humoral_immune0.80117933
166MP0005174_abnormal_tail_pigmentation0.79594277
167MP0002405_respiratory_system_inflammati0.79168326
168MP0002693_abnormal_pancreas_physiology0.79058793
169MP0000490_abnormal_crypts_of0.79019265
170MP0009764_decreased_sensitivity_to0.78009962
171MP0005310_abnormal_salivary_gland0.77013270
172MP0003448_altered_tumor_morphology0.76585786
173MP0000049_abnormal_middle_ear0.76347865
174MP0005332_abnormal_amino_acid0.76160377
175MP0003828_pulmonary_edema0.75578452
176MP0005384_cellular_phenotype0.75457322
177MP0002734_abnormal_mechanical_nocicepti0.75177654
178MP0002420_abnormal_adaptive_immunity0.75003416
179MP0001819_abnormal_immune_cell0.74589670
180MP0002084_abnormal_developmental_patter0.72663589
181MP0000703_abnormal_thymus_morphology0.71612703
182MP0004036_abnormal_muscle_relaxation0.71276411
183MP0005621_abnormal_cell_physiology0.70646610
184MP0001845_abnormal_inflammatory_respons0.70316885
185MP0000759_abnormal_skeletal_muscle0.69799912

Predicted human phenotypes

RankGene SetZ-score
1Small epiphyses (HP:0010585)5.11566960
2Hypoplasia of the capital femoral epiphysis (HP:0003090)4.81618357
3Molar tooth sign on MRI (HP:0002419)4.02494282
4Abnormality of midbrain morphology (HP:0002418)4.02494282
5Pancreatic cysts (HP:0001737)3.94836136
6Cerebral hypomyelination (HP:0006808)3.74536702
7Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)3.74395786
8Absent epiphyses (HP:0010577)3.74395786
9Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.68996458
10Acute necrotizing encephalopathy (HP:0006965)3.62954720
11Pancreatic fibrosis (HP:0100732)3.56548142
12Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.55533380
13Nephronophthisis (HP:0000090)3.48552025
14True hermaphroditism (HP:0010459)3.41341342
15Congenital stationary night blindness (HP:0007642)3.40167328
16Birth length less than 3rd percentile (HP:0003561)3.32982507
17Multiple enchondromatosis (HP:0005701)3.28521742
18Increased serum pyruvate (HP:0003542)3.23070929
19Abnormality of glycolysis (HP:0004366)3.23070929
20Impulsivity (HP:0100710)3.17144475
21Type II lissencephaly (HP:0007260)3.16799354
22Abnormal mitochondria in muscle tissue (HP:0008316)3.15963788
23Carpal bone hypoplasia (HP:0001498)3.06800546
24Flattened epiphyses (HP:0003071)3.05948791
25Recurrent abscess formation (HP:0002722)3.03621416
26Medial flaring of the eyebrow (HP:0010747)2.98322993
27Abnormal drinking behavior (HP:0030082)2.94835870
28Polydipsia (HP:0001959)2.94835870
29Abnormality of the renal medulla (HP:0100957)2.91500978
30Recurrent bacterial skin infections (HP:0005406)2.90117688
31Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.87392574
32Abnormality of alanine metabolism (HP:0010916)2.87392574
33Hyperalaninemia (HP:0003348)2.87392574
343-Methylglutaconic aciduria (HP:0003535)2.87341208
35Abnormality of the renal cortex (HP:0011035)2.86839435
36Mitochondrial inheritance (HP:0001427)2.85989018
37Sensory axonal neuropathy (HP:0003390)2.78854658
38Breast hypoplasia (HP:0003187)2.77200614
39Acute encephalopathy (HP:0006846)2.72924139
40Exercise-induced muscle cramps (HP:0003710)2.72836200
41Patellar aplasia (HP:0006443)2.70881643
42Nasal polyposis (HP:0100582)2.68756929
43Hepatocellular necrosis (HP:0001404)2.68525948
44Recurrent gram-negative bacterial infections (HP:0005420)2.66090063
45Increased CSF lactate (HP:0002490)2.65126733
46Agnosia (HP:0010524)2.55557290
47Areflexia of lower limbs (HP:0002522)2.54765099
48Progressive macrocephaly (HP:0004481)2.54446216
49Abnormal number of erythroid precursors (HP:0012131)2.54083759
50Aplasia/Hypoplasia of the patella (HP:0006498)2.51579881
51Abnormality of cells of the erythroid lineage (HP:0012130)2.49275000
52Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.48804450
53Decreased activity of mitochondrial respiratory chain (HP:0008972)2.48804450
54Concave nail (HP:0001598)2.47737057
55Irregular vertebral endplates (HP:0003301)2.46875504
56Increased hepatocellular lipid droplets (HP:0006565)2.46661326
57Gait imbalance (HP:0002141)2.44875469
58Toxemia of pregnancy (HP:0100603)2.43686644
59Abnormal rod and cone electroretinograms (HP:0008323)2.42942214
60Lipid accumulation in hepatocytes (HP:0006561)2.42638406
61Facial hemangioma (HP:0000329)2.41594250
62Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.41117868
63CNS demyelination (HP:0007305)2.41008402
64Personality changes (HP:0000751)2.38980053
65Optic disc pallor (HP:0000543)2.37558174
66Pendular nystagmus (HP:0012043)2.37086561
67Tubular atrophy (HP:0000092)2.35558214
68Congenital, generalized hypertrichosis (HP:0004540)2.35147786
69Congenital primary aphakia (HP:0007707)2.33800907
70Nephrogenic diabetes insipidus (HP:0009806)2.33721720
71Abnormality of the labia minora (HP:0012880)2.32928668
72Neuroendocrine neoplasm (HP:0100634)2.28990835
73Rhinitis (HP:0012384)2.28355232
74Methylmalonic acidemia (HP:0002912)2.28255632
75Global brain atrophy (HP:0002283)2.27838041
76Methylmalonic aciduria (HP:0012120)2.27194377
77Hepatic necrosis (HP:0002605)2.26792786
78Eczematoid dermatitis (HP:0000976)2.26786648
79Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.26402331
80Pheochromocytoma (HP:0002666)2.25146320
81Polyuria (HP:0000103)2.24878540
82Cystic liver disease (HP:0006706)2.24632041
83Absent rod-and cone-mediated responses on ERG (HP:0007688)2.24539752
84Lactic acidosis (HP:0003128)2.23579647
85Aplasia/hypoplasia of the uterus (HP:0008684)2.23173904
86Dynein arm defect of respiratory motile cilia (HP:0012255)2.22295091
87Absent/shortened dynein arms (HP:0200106)2.22295091
88Ulnar bowing (HP:0003031)2.21738591
89Hyperventilation (HP:0002883)2.21303711
90Renal Fanconi syndrome (HP:0001994)2.20775202
91Chronic bronchitis (HP:0004469)2.20092916
92Mediastinal lymphadenopathy (HP:0100721)2.18407917
93Abolished electroretinogram (ERG) (HP:0000550)2.18281241
94Chronic obstructive pulmonary disease (HP:0006510)2.17375901
95Obstructive lung disease (HP:0006536)2.17375901
96Attenuation of retinal blood vessels (HP:0007843)2.17332962
97Muscle fiber splitting (HP:0003555)2.16514066
98Poor head control (HP:0002421)2.16192737
99Respiratory failure (HP:0002878)2.15163807
100Sclerocornea (HP:0000647)2.13498459
101Lissencephaly (HP:0001339)2.12645567
102Cerebral edema (HP:0002181)2.12109878
103Trismus (HP:0000211)2.12038300
104Emotional lability (HP:0000712)2.09312497
105Pallor (HP:0000980)2.09032567
106Retinal dysplasia (HP:0007973)2.07417270
107Rough bone trabeculation (HP:0100670)2.06895662
108Reticulocytopenia (HP:0001896)2.05425216
109Rhabdomyolysis (HP:0003201)2.05317020
110Renal cortical cysts (HP:0000803)2.04309688
111Hyporeflexia of lower limbs (HP:0002600)2.03955038
112Progressive muscle weakness (HP:0003323)2.01581603
113Irregular epiphyses (HP:0010582)2.00747244
114Furrowed tongue (HP:0000221)1.99780832
115Chronic hepatic failure (HP:0100626)1.97424299
116Anencephaly (HP:0002323)1.96904812
117Overriding aorta (HP:0002623)1.95990804
118Inability to walk (HP:0002540)1.95509369
119Polyphagia (HP:0002591)1.94251241
120Pustule (HP:0200039)1.93824185
121Optic nerve hypoplasia (HP:0000609)1.91301877
122Unsteady gait (HP:0002317)1.91223386
123Abnormal spermatogenesis (HP:0008669)1.90296936
124Abnormality of lateral ventricle (HP:0030047)1.90099702
125Male pseudohermaphroditism (HP:0000037)1.89771452
126Lethargy (HP:0001254)1.89129560
127Abnormality of the vertebral endplates (HP:0005106)1.88905100
128CNS hypomyelination (HP:0003429)1.88341142
129Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.88238745
130Severe muscular hypotonia (HP:0006829)1.87436405
131Large for gestational age (HP:0001520)1.86564010
132Cellulitis (HP:0100658)1.86271593
133Leukodystrophy (HP:0002415)1.86108881
134Congenital hepatic fibrosis (HP:0002612)1.86005056
135Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.85393868
136Bile duct proliferation (HP:0001408)1.84798878
137Abnormal biliary tract physiology (HP:0012439)1.84798878
138Decreased electroretinogram (ERG) amplitude (HP:0000654)1.84313233
139Axonal loss (HP:0003447)1.83611509
140Abnormality of macrophages (HP:0004311)1.83372742
141Muscle fiber inclusion bodies (HP:0100299)1.82877203
142Stomatitis (HP:0010280)1.82567917
143Increased intramyocellular lipid droplets (HP:0012240)1.82507112
144Exertional dyspnea (HP:0002875)1.82080370
145Genital tract atresia (HP:0001827)1.81830292
146Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.81682467
147Glycosuria (HP:0003076)1.81679562
148Abnormality of urine glucose concentration (HP:0011016)1.81679562
149Tracheoesophageal fistula (HP:0002575)1.81612026
150Oligodactyly (hands) (HP:0001180)1.80921947
151Abnormal respiratory epithelium morphology (HP:0012253)1.78966554
152Abnormal respiratory motile cilium morphology (HP:0005938)1.78966554
153Abnormal ciliary motility (HP:0012262)1.78877503
154Vaginal atresia (HP:0000148)1.78537414
155Decreased central vision (HP:0007663)1.78284594
156Abnormality of the anterior horn cell (HP:0006802)1.78214078
157Degeneration of anterior horn cells (HP:0002398)1.78214078
158Agitation (HP:0000713)1.77433317
159Hypoplasia of the pons (HP:0012110)1.76872112
160Abnormal trabecular bone morphology (HP:0100671)1.76424640
161Nausea (HP:0002018)1.76341992
162Nemaline bodies (HP:0003798)1.76102228
163Abnormal urine output (HP:0012590)1.75601240
164Aplasia/Hypoplasia of the tongue (HP:0010295)1.73980707
165Ketoacidosis (HP:0001993)1.73702774
166Abnormal respiratory motile cilium physiology (HP:0012261)1.73423979
167Hypomagnesemia (HP:0002917)1.72941299
168Cafe-au-lait spot (HP:0000957)1.72896799
169Absent thumb (HP:0009777)1.70875736
170Abnormality of the pons (HP:0007361)1.70613647
171Increased serum lactate (HP:0002151)1.69599340
172Meckel diverticulum (HP:0002245)1.69024525
173Macrocytic anemia (HP:0001972)1.68447657
174Premature ovarian failure (HP:0008209)1.67805722
175Premature graying of hair (HP:0002216)1.67569713
176Abnormality of the ileum (HP:0001549)1.67369663
177Abnormality of chromosome stability (HP:0003220)1.64687779

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.71274112
2FRK4.17807537
3TESK23.50454853
4ADRBK23.49042395
5MAP3K103.36647713
6PBK3.22616647
7CDC73.11422824
8WNK32.94182682
9WEE12.59331553
10STK162.56711908
11ZAK2.49362322
12PDK42.44978073
13PDK32.44978073
14PLK42.44907819
15MAP4K22.41861363
16BMPR1B2.41365470
17BRSK22.36694650
18PASK2.36674321
19NEK22.28841610
20NUAK12.25842449
21PINK12.19303382
22GRK12.15144085
23WNK42.14541381
24TESK12.12867707
25TLK11.96602317
26NME21.96192777
27INSRR1.95606963
28BLK1.82231640
29EIF2AK11.79919413
30ACVR1B1.74403613
31BRSK11.68141973
32SRPK11.67171066
33MAPK131.66725784
34BCKDK1.62201856
35LIMK11.59891716
36CASK1.55122857
37PLK11.50997646
38TAOK31.49395943
39CDK41.49156818
40VRK21.45494680
41DAPK21.40645475
42BRAF1.40321724
43NEK11.38510644
44TNIK1.36879424
45PHKG21.35951800
46PHKG11.35951800
47TRIB31.34682266
48MAP3K41.28027457
49EIF2AK31.26994520
50ABL21.26531168
51CDK121.26489526
52DYRK31.24758405
53AURKB1.19203143
54PDK21.18816852
55MARK31.17802740
56ADRBK11.17401878
57STK41.15640438
58LATS21.15518683
59VRK11.12818073
60PIM21.12799010
61MARK11.12261331
62STK101.11634615
63PAK31.11535964
64MAP2K71.09653123
65TBK11.08473906
66RIPK41.07062905
67OXSR11.05711132
68CHEK21.04390262
69SIK21.04066335
70RPS6KA41.03434295
71CHEK11.01945316
72CDK71.00244783
73TGFBR10.97238072
74PRKCG0.96151148
75PKN20.96092426
76TXK0.95062927
77CSNK1G20.94941106
78CDK80.94382866
79SCYL20.94181307
80MAP3K110.93315706
81STK38L0.91397627
82SIK30.91134942
83TTK0.90643878
84CAMKK20.90156788
85PAK40.90078282
86TAOK10.89644989
87STK30.88164954
88CSNK1G30.88142415
89CCNB10.87994246
90NEK90.87235680
91MUSK0.87005306
92STK390.85371549
93PAK10.83876912
94PLK30.82522223
95MAPKAPK30.82362192
96MAP2K60.81933020
97PKN10.79807283
98NTRK30.78722997
99CSNK1G10.78372363
100OBSCN0.77589756
101NTRK20.76554411
102MST40.76438589
103MAPK150.75928687
104TSSK60.75342666
105TYK20.75275654
106ARAF0.74670805
107PRKCQ0.74444804
108AURKA0.73684788
109MAP3K80.72846451
110GRK70.72738683
111AKT30.71716028
112ALK0.71586133
113PRKCE0.71501463
114ERN10.71034597
115TRIM280.67604508
116ATR0.65045927
117NME10.62751197
118GRK60.62741080
119PIM10.62426769
120PNCK0.62233949
121CSNK1A1L0.61935493
122TTN0.61503306
123CAMK10.61320570
124PRKACA0.61130161
125CDK20.60230601
126YES10.58772349
127RPS6KA50.57548863
128CSNK1A10.56928999
129MST1R0.56166528
130CAMK2A0.54492581
131ERBB40.54341594
132MAP4K10.53395824
133PIK3CA0.53218165
134MAPKAPK20.52968411
135CHUK0.52825106
136PRKCZ0.51421356
137IRAK40.50952675
138TNK20.49965329
139MAP2K20.49284090
140STK110.48823174
141MKNK20.48513343
142CDK10.47748670
143ITK0.47547596
144AKT20.47413192
145RPS6KA60.47061201
146TIE10.46996169
147CSNK2A20.46740071
148FGFR20.46149193
149EPHA40.43809822
150TYRO30.43045773
151CSNK2A10.42529214
152CDK190.42451461
153DYRK20.42218105
154IKBKE0.42146719
155IKBKB0.41813840
156PRKCA0.40814827
157EPHA30.40447260
158MAP2K40.40327612
159CAMKK10.40319489
160PRKG10.40210690
161PLK20.38279836
162IRAK10.36992754
163MTOR0.35368174
164ZAP700.32485412
165EPHB20.32401792
166PRKCI0.31878646
167SYK0.30900044
168BTK0.29839451
169ATM0.28332160
170PTK2B0.27858786
171UHMK10.26826781
172MAP3K90.26266886
173EGFR0.24452315
174CSNK1E0.23648885

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.71835528
2DNA replication_Homo sapiens_hsa030303.34067680
3RNA polymerase_Homo sapiens_hsa030203.15528320
4Spliceosome_Homo sapiens_hsa030403.14280457
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.06057848
6Oxidative phosphorylation_Homo sapiens_hsa001902.79359780
7Homologous recombination_Homo sapiens_hsa034402.78085814
8Mismatch repair_Homo sapiens_hsa034302.63057160
9RNA transport_Homo sapiens_hsa030132.58811648
10Ribosome_Homo sapiens_hsa030102.58784041
11Base excision repair_Homo sapiens_hsa034102.49146902
12Basal transcription factors_Homo sapiens_hsa030222.43089010
13Parkinsons disease_Homo sapiens_hsa050122.40655875
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.24607547
15Pentose phosphate pathway_Homo sapiens_hsa000302.23258609
16Phototransduction_Homo sapiens_hsa047442.20290827
17Huntingtons disease_Homo sapiens_hsa050162.16148900
18Cell cycle_Homo sapiens_hsa041102.10316295
19Pyrimidine metabolism_Homo sapiens_hsa002402.05970869
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.03077677
21Linoleic acid metabolism_Homo sapiens_hsa005911.97142741
22Nitrogen metabolism_Homo sapiens_hsa009101.90796189
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.90274532
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.87788346
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.74733226
26Butanoate metabolism_Homo sapiens_hsa006501.72449266
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.67398801
28Nucleotide excision repair_Homo sapiens_hsa034201.64159633
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.60722347
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.58750733
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.57744319
32Nicotine addiction_Homo sapiens_hsa050331.57391022
33Vitamin B6 metabolism_Homo sapiens_hsa007501.56959225
34Tryptophan metabolism_Homo sapiens_hsa003801.51948465
35Systemic lupus erythematosus_Homo sapiens_hsa053221.49409133
36Legionellosis_Homo sapiens_hsa051341.49238666
37Biosynthesis of amino acids_Homo sapiens_hsa012301.44475062
38Alzheimers disease_Homo sapiens_hsa050101.42513189
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.37949271
40Epstein-Barr virus infection_Homo sapiens_hsa051691.35137489
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.26231520
42RNA degradation_Homo sapiens_hsa030181.25112104
43mRNA surveillance pathway_Homo sapiens_hsa030151.22121406
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.19240240
45Caffeine metabolism_Homo sapiens_hsa002321.16803571
46Carbon metabolism_Homo sapiens_hsa012001.16786633
47Sulfur relay system_Homo sapiens_hsa041221.15529228
48Peroxisome_Homo sapiens_hsa041461.14958991
49Ether lipid metabolism_Homo sapiens_hsa005651.14289494
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.14072902
51Intestinal immune network for IgA production_Homo sapiens_hsa046721.09895673
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.03875347
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.03374663
54Folate biosynthesis_Homo sapiens_hsa007901.02414310
55Morphine addiction_Homo sapiens_hsa050321.01435885
56Cardiac muscle contraction_Homo sapiens_hsa042601.01238333
57One carbon pool by folate_Homo sapiens_hsa006701.00284795
58Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.99885896
59Fanconi anemia pathway_Homo sapiens_hsa034600.98420843
60Olfactory transduction_Homo sapiens_hsa047400.98392743
61Steroid biosynthesis_Homo sapiens_hsa001000.96103400
62Phagosome_Homo sapiens_hsa041450.93107519
63Purine metabolism_Homo sapiens_hsa002300.92335729
64Arachidonic acid metabolism_Homo sapiens_hsa005900.91246882
65p53 signaling pathway_Homo sapiens_hsa041150.90984973
66Herpes simplex infection_Homo sapiens_hsa051680.90227069
67Primary immunodeficiency_Homo sapiens_hsa053400.89723614
68Propanoate metabolism_Homo sapiens_hsa006400.88529326
69Viral carcinogenesis_Homo sapiens_hsa052030.87871254
70Arginine and proline metabolism_Homo sapiens_hsa003300.86589782
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.86426832
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.86013705
73Chemical carcinogenesis_Homo sapiens_hsa052040.85263167
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84517004
75Primary bile acid biosynthesis_Homo sapiens_hsa001200.83743736
76Leishmaniasis_Homo sapiens_hsa051400.83411869
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.81161735
78Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.80551503
79Taste transduction_Homo sapiens_hsa047420.78299462
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77109772
81Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.74982403
82Serotonergic synapse_Homo sapiens_hsa047260.74825531
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74472553
84Collecting duct acid secretion_Homo sapiens_hsa049660.74275294
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.73833997
86Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.73685290
87Tuberculosis_Homo sapiens_hsa051520.72889839
88Pyruvate metabolism_Homo sapiens_hsa006200.69878588
89Oocyte meiosis_Homo sapiens_hsa041140.69604894
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69350418
91GABAergic synapse_Homo sapiens_hsa047270.67631072
92Insulin secretion_Homo sapiens_hsa049110.66778314
93Antigen processing and presentation_Homo sapiens_hsa046120.66117217
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64562470
95Mineral absorption_Homo sapiens_hsa049780.63653873
96Retinol metabolism_Homo sapiens_hsa008300.63455960
97Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.61131553
98Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.60630828
99Staphylococcus aureus infection_Homo sapiens_hsa051500.60066903
100Apoptosis_Homo sapiens_hsa042100.59973568
101ABC transporters_Homo sapiens_hsa020100.59867518
102Rheumatoid arthritis_Homo sapiens_hsa053230.58446004
103Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57415200
104Protein export_Homo sapiens_hsa030600.57033123
1052-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.56506406
106beta-Alanine metabolism_Homo sapiens_hsa004100.56425738
107Regulation of autophagy_Homo sapiens_hsa041400.56094246
108Non-homologous end-joining_Homo sapiens_hsa034500.55666709
109Circadian entrainment_Homo sapiens_hsa047130.55078263
110SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54628140
111Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53121984
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52785859
113Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.52345532
114Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.52129183
115NF-kappa B signaling pathway_Homo sapiens_hsa040640.51403201
116Type I diabetes mellitus_Homo sapiens_hsa049400.51176462
117Toll-like receptor signaling pathway_Homo sapiens_hsa046200.50925810
118Ovarian steroidogenesis_Homo sapiens_hsa049130.50619111
119Glycerolipid metabolism_Homo sapiens_hsa005610.49285573
120Selenocompound metabolism_Homo sapiens_hsa004500.48940978
121Asthma_Homo sapiens_hsa053100.47445359
122HTLV-I infection_Homo sapiens_hsa051660.47073423
123Renal cell carcinoma_Homo sapiens_hsa052110.47042840
124Graft-versus-host disease_Homo sapiens_hsa053320.46709716
125Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46466095
126Osteoclast differentiation_Homo sapiens_hsa043800.45321408
127HIF-1 signaling pathway_Homo sapiens_hsa040660.45143242
128Metabolic pathways_Homo sapiens_hsa011000.44430837
129Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.43618216
130Shigellosis_Homo sapiens_hsa051310.43008842
131Glutamatergic synapse_Homo sapiens_hsa047240.42482110
132Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41507479
133Fructose and mannose metabolism_Homo sapiens_hsa000510.41502646
134Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41281483
135Lysosome_Homo sapiens_hsa041420.38905543
136Allograft rejection_Homo sapiens_hsa053300.38880142
137B cell receptor signaling pathway_Homo sapiens_hsa046620.38781059
138Autoimmune thyroid disease_Homo sapiens_hsa053200.38575152
139Cocaine addiction_Homo sapiens_hsa050300.38278764
140Calcium signaling pathway_Homo sapiens_hsa040200.37824456
141Measles_Homo sapiens_hsa051620.37622651
142Influenza A_Homo sapiens_hsa051640.37498955
143Pertussis_Homo sapiens_hsa051330.37409233
144Chronic myeloid leukemia_Homo sapiens_hsa052200.37006687
145Hepatitis B_Homo sapiens_hsa051610.34473955
146NOD-like receptor signaling pathway_Homo sapiens_hsa046210.34394970
147Vitamin digestion and absorption_Homo sapiens_hsa049770.34135472
148Drug metabolism - other enzymes_Homo sapiens_hsa009830.33873130
149Synaptic vesicle cycle_Homo sapiens_hsa047210.33816291
150Dopaminergic synapse_Homo sapiens_hsa047280.32333171
151Phenylalanine metabolism_Homo sapiens_hsa003600.29451248
152Vibrio cholerae infection_Homo sapiens_hsa051100.29130718
153Fat digestion and absorption_Homo sapiens_hsa049750.28889554
154Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.24765679
155Glutathione metabolism_Homo sapiens_hsa004800.24464558
156Glycosaminoglycan degradation_Homo sapiens_hsa005310.23932279
157Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.23181009
158Sulfur metabolism_Homo sapiens_hsa009200.21820121
159Viral myocarditis_Homo sapiens_hsa054160.21212904

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