SNRNP40

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a component of the U5 small nuclear ribonucleoprotein (snRNP) particle. The U5 snRNP is part of the spliceosome, a multiprotein complex that catalyzes the removal of introns from pre-messenger RNAs. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.22369919
2viral transcription (GO:0019083)5.06052077
3ribosomal small subunit biogenesis (GO:0042274)4.95137329
4DNA deamination (GO:0045006)4.91524265
5translational termination (GO:0006415)4.90393599
6telomere maintenance via semi-conservative replication (GO:0032201)4.89754883
7DNA strand elongation involved in DNA replication (GO:0006271)4.88609938
8DNA replication initiation (GO:0006270)4.76672109
9maturation of SSU-rRNA (GO:0030490)4.72449252
10DNA strand elongation (GO:0022616)4.67456210
11ribosomal large subunit biogenesis (GO:0042273)4.54710944
12telomere maintenance via recombination (GO:0000722)4.29516568
13translational elongation (GO:0006414)4.25963322
14SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.25306554
15proteasome assembly (GO:0043248)4.18883146
16cotranslational protein targeting to membrane (GO:0006613)4.16577859
17protein targeting to ER (GO:0045047)4.14372133
18translational initiation (GO:0006413)4.07023101
19nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.99684226
20mitotic recombination (GO:0006312)3.98665057
21DNA unwinding involved in DNA replication (GO:0006268)3.92654454
22establishment of protein localization to endoplasmic reticulum (GO:0072599)3.91784753
23protein localization to endoplasmic reticulum (GO:0070972)3.90500020
24telomere maintenance via telomere lengthening (GO:0010833)3.89742324
25DNA replication checkpoint (GO:0000076)3.87893316
26mitotic sister chromatid segregation (GO:0000070)3.87697047
27regulation of mitochondrial translation (GO:0070129)3.81957544
28ribonucleoprotein complex biogenesis (GO:0022613)3.81915996
29viral life cycle (GO:0019058)3.81792776
30cellular protein complex disassembly (GO:0043624)3.80768328
31establishment of viral latency (GO:0019043)3.67451079
32CENP-A containing nucleosome assembly (GO:0034080)3.62327797
33nucleotide-excision repair, DNA gap filling (GO:0006297)3.59652545
34cullin deneddylation (GO:0010388)3.55953122
35sister chromatid segregation (GO:0000819)3.55757309
36chromatin remodeling at centromere (GO:0031055)3.54013848
37formation of translation preinitiation complex (GO:0001731)3.51953667
38regulation of cellular amino acid metabolic process (GO:0006521)3.51129156
39rRNA processing (GO:0006364)3.50174700
40mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.48650369
41somatic hypermutation of immunoglobulin genes (GO:0016446)3.47865440
42somatic diversification of immune receptors via somatic mutation (GO:0002566)3.47865440
43deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.46836918
44positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.46592942
45signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.46358669
46signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.46358669
47signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.46358669
48spliceosomal snRNP assembly (GO:0000387)3.44272544
49protein deneddylation (GO:0000338)3.43925410
50signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.43736823
51intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.43736823
52protein complex disassembly (GO:0043241)3.43434189
53DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.43394115
54pseudouridine synthesis (GO:0001522)3.43074430
55negative regulation of chromosome segregation (GO:0051985)3.39621022
56negative regulation of mitotic sister chromatid separation (GO:2000816)3.38605522
57negative regulation of sister chromatid segregation (GO:0033046)3.38605522
58negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.38605522
59negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.38605522
60negative regulation of mitotic sister chromatid segregation (GO:0033048)3.38605522
61spindle checkpoint (GO:0031577)3.38514011
62rRNA metabolic process (GO:0016072)3.38390370
63nuclear pore complex assembly (GO:0051292)3.37990110
64signal transduction involved in DNA damage checkpoint (GO:0072422)3.37938369
65signal transduction involved in DNA integrity checkpoint (GO:0072401)3.37938369
66DNA double-strand break processing (GO:0000729)3.37528044
67mitotic spindle checkpoint (GO:0071174)3.36979724
68kinetochore organization (GO:0051383)3.36807661
69establishment of protein localization to mitochondrial membrane (GO:0090151)3.35994804
70signal transduction involved in cell cycle checkpoint (GO:0072395)3.33569504
71DNA catabolic process, exonucleolytic (GO:0000738)3.33399255
72positive regulation of ligase activity (GO:0051351)3.32125395
73DNA replication-dependent nucleosome organization (GO:0034723)3.31742468
74DNA replication-dependent nucleosome assembly (GO:0006335)3.31742468
75kinetochore assembly (GO:0051382)3.29093303
76translation (GO:0006412)3.27767119
77regulation of ubiquitin-protein transferase activity (GO:0051438)3.27745411
78non-recombinational repair (GO:0000726)3.27076085
79double-strand break repair via nonhomologous end joining (GO:0006303)3.27076085
80ribosome assembly (GO:0042255)3.25130931
81regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.24475635
82establishment of integrated proviral latency (GO:0075713)3.24005126
83macromolecular complex disassembly (GO:0032984)3.23854985
84replication fork processing (GO:0031297)3.23684263
85DNA replication-independent nucleosome organization (GO:0034724)3.23178173
86DNA replication-independent nucleosome assembly (GO:0006336)3.23178173
87transcription-coupled nucleotide-excision repair (GO:0006283)3.23056814
88nuclear pore organization (GO:0006999)3.22739258
89nuclear-transcribed mRNA catabolic process (GO:0000956)3.22674175
90mitotic spindle assembly checkpoint (GO:0007094)3.22019530
91chaperone-mediated protein transport (GO:0072321)3.19519588
92mitotic metaphase plate congression (GO:0007080)3.18671618
93spindle assembly checkpoint (GO:0071173)3.17766527
94regulation of ligase activity (GO:0051340)3.16321960
95nucleobase biosynthetic process (GO:0046112)3.16207143
96ribosome biogenesis (GO:0042254)3.15625158
97termination of RNA polymerase III transcription (GO:0006386)3.13320345
98transcription elongation from RNA polymerase III promoter (GO:0006385)3.13320345
99protein localization to kinetochore (GO:0034501)3.11741895
100IMP metabolic process (GO:0046040)3.10680933
101DNA damage response, detection of DNA damage (GO:0042769)3.09706682
102regulation of double-strand break repair via homologous recombination (GO:0010569)3.09221677
103mRNA catabolic process (GO:0006402)3.08947782
104DNA topological change (GO:0006265)3.07258270
105nuclear envelope disassembly (GO:0051081)3.07206925
106membrane disassembly (GO:0030397)3.07206925
107exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.05225082
108tRNA aminoacylation for protein translation (GO:0006418)3.05150287
109spliceosomal complex assembly (GO:0000245)3.03931846
110negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.03709782
111base-excision repair (GO:0006284)3.03224488
112RNA catabolic process (GO:0006401)3.03036688
113rRNA modification (GO:0000154)2.98973070
114nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.93122214
115anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.92732124
116cellular component biogenesis (GO:0044085)2.91960290
117protein localization to chromosome, centromeric region (GO:0071459)2.89915596
118viral mRNA export from host cell nucleus (GO:0046784)2.89570825
119histone exchange (GO:0043486)2.89349131
120regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.87889347
121telomere organization (GO:0032200)2.87700802
122telomere maintenance (GO:0000723)2.86756639
123maturation of 5.8S rRNA (GO:0000460)2.85895867
124purine nucleobase biosynthetic process (GO:0009113)2.83400101
125positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.82317893
126metaphase plate congression (GO:0051310)2.82287424
127DNA ligation (GO:0006266)2.81728188
128tRNA methylation (GO:0030488)2.80314970
1297-methylguanosine mRNA capping (GO:0006370)2.79393001
130negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.78780556
131negative regulation of ligase activity (GO:0051352)2.78780556
132ncRNA processing (GO:0034470)2.78543784
133G1/S transition of mitotic cell cycle (GO:0000082)2.76623210
134cell cycle G1/S phase transition (GO:0044843)2.76623210
135regulation of nuclear cell cycle DNA replication (GO:0033262)2.76495409
136* RNA splicing, via transesterification reactions (GO:0000375)2.76457047
1377-methylguanosine RNA capping (GO:0009452)2.75261033
138RNA capping (GO:0036260)2.75261033
139* mRNA splicing, via spliceosome (GO:0000398)2.74865024
140* RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.74865024
141mismatch repair (GO:0006298)2.74208600
142termination of RNA polymerase I transcription (GO:0006363)2.73921309
143IMP biosynthetic process (GO:0006188)2.73644529
144negative regulation of RNA splicing (GO:0033119)2.73166273
145transcription elongation from RNA polymerase I promoter (GO:0006362)2.71875168
146termination of RNA polymerase II transcription (GO:0006369)2.71083387
147DNA-templated transcription, termination (GO:0006353)2.70650003
148tRNA modification (GO:0006400)2.70221258
149mitotic nuclear envelope disassembly (GO:0007077)2.70118048

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.41467359
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.49218276
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.73445066
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.53272589
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.50349856
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.47386637
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.29425981
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.23714439
9GABP_17652178_ChIP-ChIP_JURKAT_Human3.17289085
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.08641303
11MYC_19079543_ChIP-ChIP_MESCs_Mouse3.06152277
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.03960637
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.94705817
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.94024728
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.89634838
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.74282647
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.69396223
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.56857408
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.53775094
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.44028231
21VDR_23849224_ChIP-Seq_CD4+_Human2.43900781
22* XRN2_22483619_ChIP-Seq_HELA_Human2.38212260
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.29209032
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.23610918
25FOXP3_21729870_ChIP-Seq_TREG_Human2.16773419
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.13996497
27TTF2_22483619_ChIP-Seq_HELA_Human2.04475895
28MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.04339845
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.03209739
30MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.02072499
31DCP1A_22483619_ChIP-Seq_HELA_Human2.01656569
32E2F1_18555785_ChIP-Seq_MESCs_Mouse2.00841613
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.95197472
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.82806318
35GABP_19822575_ChIP-Seq_HepG2_Human1.80209940
36E2F1_21310950_ChIP-Seq_MCF-7_Human1.78816009
37TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.77987707
38ELK1_19687146_ChIP-ChIP_HELA_Human1.75570694
39YY1_21170310_ChIP-Seq_MESCs_Mouse1.74937853
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.74291609
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.71595362
42MYCN_18555785_ChIP-Seq_MESCs_Mouse1.68776299
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.66849500
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.65858381
45HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.63190880
46ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.58930622
47AR_21909140_ChIP-Seq_LNCAP_Human1.55467672
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54832030
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.54434435
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.54359149
51TP63_19390658_ChIP-ChIP_HaCaT_Human1.50258352
52CIITA_25753668_ChIP-Seq_RAJI_Human1.49739248
53ERG_20887958_ChIP-Seq_HPC-7_Mouse1.48209081
54SRF_21415370_ChIP-Seq_HL-1_Mouse1.47270793
55NOTCH1_21737748_ChIP-Seq_TLL_Human1.46587485
56YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43886026
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.43331875
58SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.42077289
59SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.38735644
60CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.38647263
61ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35433519
62MYC_22102868_ChIP-Seq_BL_Human1.33128201
63KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.29294668
64MYC_18940864_ChIP-ChIP_HL60_Human1.28780452
65CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.23969008
66SALL1_21062744_ChIP-ChIP_HESCs_Human1.21068701
67* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.20313871
68KDM5A_27292631_Chip-Seq_BREAST_Human1.19257541
69SOX2_18555785_ChIP-Seq_MESCs_Mouse1.14921126
70EGR1_19374776_ChIP-ChIP_THP-1_Human1.14443775
71SPI1_23547873_ChIP-Seq_NB4_Human1.14435929
72SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.11051092
73* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09285863
74KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.08386178
75KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.08386178
76KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.08386178
77ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07194319
78PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.06209890
79ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.05579994
80CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.04740692
81IRF1_19129219_ChIP-ChIP_H3396_Human1.04708742
82CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03263649
83NANOG_16153702_ChIP-ChIP_HESCs_Human1.02975932
84ELK1_22589737_ChIP-Seq_MCF10A_Human1.02612877
85GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.02351748
86PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.02000864
87SOX2_16153702_ChIP-ChIP_HESCs_Human0.99864782
88IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.99570583
89CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99238158
90VDR_21846776_ChIP-Seq_THP-1_Human0.98753121
91PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98125378
92CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97040052
93TFEB_21752829_ChIP-Seq_HELA_Human0.94078637
94HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.91239008
95POU5F1_16153702_ChIP-ChIP_HESCs_Human0.90350557
96EWS_26573619_Chip-Seq_HEK293_Human0.89916167
97KLF4_18555785_ChIP-Seq_MESCs_Mouse0.89044168
98DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.88867380
99SOX17_20123909_ChIP-Seq_XEN_Mouse0.88218825
100ZNF274_21170338_ChIP-Seq_K562_Hela0.88088264
101STAT3_1855785_ChIP-Seq_MESCs_Mouse0.87506155
102POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.85325823
103BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.83460640
104TCF3_18692474_ChIP-Seq_MEFs_Mouse0.79708004
105HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.78168976
106KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.76924471
107NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.75350022
108* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75215323
109CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.75055072
110STAT4_19710469_ChIP-ChIP_TH1__Mouse0.74516192
111SOX2_18692474_ChIP-Seq_MEFs_Mouse0.73162775
112DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.70894524
113CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.70867300
114SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.69070675
115RBPJ_22232070_ChIP-Seq_NCS_Mouse0.68861814
116TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.63423259
117TBX5_21415370_ChIP-Seq_HL-1_Mouse0.60522137

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.65347566
2MP0010094_abnormal_chromosome_stability4.09925323
3MP0004957_abnormal_blastocyst_morpholog3.67559222
4MP0003111_abnormal_nucleus_morphology3.60357437
5MP0003077_abnormal_cell_cycle3.33967998
6MP0008057_abnormal_DNA_replication3.33735945
7MP0008058_abnormal_DNA_repair3.32972618
8MP0006292_abnormal_olfactory_placode2.84458044
9MP0008007_abnormal_cellular_replicative2.68302741
10MP0003136_yellow_coat_color2.59727479
11MP0009379_abnormal_foot_pigmentation2.58327911
12MP0008932_abnormal_embryonic_tissue2.46500999
13MP0009697_abnormal_copulation2.43847671
14MP0003806_abnormal_nucleotide_metabolis2.32935041
15MP0002396_abnormal_hematopoietic_system2.14267096
16MP0006035_abnormal_mitochondrial_morpho2.03649224
17MP0000490_abnormal_crypts_of2.03538077
18MP0003786_premature_aging1.91317802
19MP0003763_abnormal_thymus_physiology1.87010591
20MP0009333_abnormal_splenocyte_physiolog1.86854560
21MP0006036_abnormal_mitochondrial_physio1.84301544
22MP0005174_abnormal_tail_pigmentation1.74364854
23MP0003315_abnormal_perineum_morphology1.73484335
24MP0003186_abnormal_redox_activity1.69619288
25MP0000350_abnormal_cell_proliferation1.67251563
26MP0003718_maternal_effect1.63543150
27MP0004147_increased_porphyrin_level1.62279245
28MP0008877_abnormal_DNA_methylation1.56034886
29MP0004381_abnormal_hair_follicle1.54962214
30MP0001529_abnormal_vocalization1.53414411
31MP0001188_hyperpigmentation1.50038040
32MP0003123_paternal_imprinting1.47323473
33MP0001730_embryonic_growth_arrest1.45121481
34MP0000358_abnormal_cell_content/1.42652402
35MP0008995_early_reproductive_senescence1.35125534
36MP0005409_darkened_coat_color1.34576373
37MP0002398_abnormal_bone_marrow1.32253393
38MP0000015_abnormal_ear_pigmentation1.31392080
39MP0002102_abnormal_ear_morphology1.30754514
40MP0002019_abnormal_tumor_incidence1.30630513
41MP0005075_abnormal_melanosome_morpholog1.30569841
42MP0000703_abnormal_thymus_morphology1.30382544
43MP0000313_abnormal_cell_death1.29578063
44MP0003890_abnormal_embryonic-extraembry1.26353151
45MP0002095_abnormal_skin_pigmentation1.23472991
46MP0004808_abnormal_hematopoietic_stem1.22785165
47MP0000049_abnormal_middle_ear1.21381471
48MP0005671_abnormal_response_to1.20594900
49MP0010030_abnormal_orbit_morphology1.20278311
50MP0000566_synostosis1.19279582
51MP0002722_abnormal_immune_system1.18412176
52MP0002210_abnormal_sex_determination1.18116289
53MP0006072_abnormal_retinal_apoptosis1.17537903
54MP0002938_white_spotting1.16927986
55MP0008789_abnormal_olfactory_epithelium1.16662336
56MP0002132_abnormal_respiratory_system1.16648012
57MP0001697_abnormal_embryo_size1.15001875
58MP0002085_abnormal_embryonic_tissue1.14793966
59MP0002160_abnormal_reproductive_system1.13645054
60MP0002080_prenatal_lethality1.12152844
61MP0000689_abnormal_spleen_morphology1.11253896
62MP0001293_anophthalmia1.10372630
63MP0009672_abnormal_birth_weight1.06104491
64MP0001672_abnormal_embryogenesis/_devel1.05694985
65MP0005380_embryogenesis_phenotype1.05694985
66MP0001764_abnormal_homeostasis1.04627158
67MP0003567_abnormal_fetal_cardiomyocyte1.04507289
68MP0002429_abnormal_blood_cell1.03827623
69MP0003938_abnormal_ear_development1.01637384
70MP0000716_abnormal_immune_system1.00126916
71MP0001835_abnormal_antigen_presentation0.99687853
72MP0001800_abnormal_humoral_immune0.98831758
73MP0009785_altered_susceptibility_to0.98705030
74MP0001145_abnormal_male_reproductive0.98570024
75MP0000858_altered_metastatic_potential0.97075653
76MP0002420_abnormal_adaptive_immunity0.95744430
77MP0001819_abnormal_immune_cell0.94084715
78MP0002277_abnormal_respiratory_mucosa0.93895773
79MP0003221_abnormal_cardiomyocyte_apopto0.93365646
80MP0004133_heterotaxia0.92813353
81MP0000465_gastrointestinal_hemorrhage0.91666921
82MP0008260_abnormal_autophagy0.91372869
83MP0001545_abnormal_hematopoietic_system0.89770110
84MP0005397_hematopoietic_system_phenotyp0.89770110
85MP0002452_abnormal_antigen_presenting0.89540764
86MP0010352_gastrointestinal_tract_polyps0.89417118
87MP0005389_reproductive_system_phenotype0.89309830
88MP0002084_abnormal_developmental_patter0.88349689
89MP0001919_abnormal_reproductive_system0.87937432
90MP0003937_abnormal_limbs/digits/tail_de0.87467179
91MP0002723_abnormal_immune_serum0.86332299
92MP0010307_abnormal_tumor_latency0.85943892
93MP0002111_abnormal_tail_morphology0.84955942
94MP0003941_abnormal_skin_development0.84487423
95MP0001929_abnormal_gametogenesis0.84447089
96MP0003984_embryonic_growth_retardation0.84276521
97MP0002234_abnormal_pharynx_morphology0.83331271
98MP0000653_abnormal_sex_gland0.82461715
99MP0003121_genomic_imprinting0.82082240
100MP0002751_abnormal_autonomic_nervous0.82073947
101MP0002088_abnormal_embryonic_growth/wei0.81813883
102MP0005000_abnormal_immune_tolerance0.80178231
103MP0001661_extended_life_span0.78382784
104MP0005025_abnormal_response_to0.78348002
105MP0001119_abnormal_female_reproductive0.77864871
106MP0002249_abnormal_larynx_morphology0.77159673
107MP0000685_abnormal_immune_system0.76919225
108MP0002177_abnormal_outer_ear0.76534626
109MP0003119_abnormal_digestive_system0.76420377
110MP0001853_heart_inflammation0.76288276
111MP0002405_respiratory_system_inflammati0.76274941
112MP0005084_abnormal_gallbladder_morpholo0.75462912
113MP0004197_abnormal_fetal_growth/weight/0.75131692
114MP0002148_abnormal_hypersensitivity_rea0.75110705
115MP0005394_taste/olfaction_phenotype0.73906716
116MP0005499_abnormal_olfactory_system0.73906716
117MP0001727_abnormal_embryo_implantation0.73697287
118MP0002086_abnormal_extraembryonic_tissu0.73029699
119MP0002163_abnormal_gland_morphology0.72679037
120MP0000372_irregular_coat_pigmentation0.72666224
121MP0001286_abnormal_eye_development0.72587793
122MP0005395_other_phenotype0.72103656
123MP0000647_abnormal_sebaceous_gland0.71096180
124MP0003698_abnormal_male_reproductive0.68894351
125MP0005253_abnormal_eye_physiology0.68683410
126MP0005384_cellular_phenotype0.66126094
127MP0002233_abnormal_nose_morphology0.65522458
128MP0005645_abnormal_hypothalamus_physiol0.62173742
129MP0005391_vision/eye_phenotype0.61917439
130MP0009703_decreased_birth_body0.61497864
131MP0002090_abnormal_vision0.58851507
132MP0002697_abnormal_eye_size0.57797504
133MP0002736_abnormal_nociception_after0.57369758
134MP0005408_hypopigmentation0.56960949
135MP0000537_abnormal_urethra_morphology0.55026478
136MP0008873_increased_physiological_sensi0.54175577
137MP0002161_abnormal_fertility/fecundity0.53957821
138MP0001346_abnormal_lacrimal_gland0.53459219
139MP0008872_abnormal_physiological_respon0.53339903
140MP0003699_abnormal_female_reproductive0.50086836

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.16791059
2Abnormality of cells of the erythroid lineage (HP:0012130)5.00115355
3Abnormal number of erythroid precursors (HP:0012131)4.79085505
4Birth length less than 3rd percentile (HP:0003561)4.18065888
5Acute necrotizing encephalopathy (HP:0006965)3.64942301
6Macrocytic anemia (HP:0001972)3.60693801
7Acute encephalopathy (HP:0006846)3.55846295
8Abnormal mitochondria in muscle tissue (HP:0008316)3.49451508
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.45826644
10Chromsome breakage (HP:0040012)3.41435318
11Pallor (HP:0000980)3.36852194
12Breast hypoplasia (HP:0003187)3.31081505
13Increased CSF lactate (HP:0002490)3.27720630
14Abnormality of glycolysis (HP:0004366)3.24487462
15Mitochondrial inheritance (HP:0001427)3.22437616
16Hepatocellular necrosis (HP:0001404)3.21401162
17Aplasia/Hypoplasia of the sacrum (HP:0008517)3.20311401
18Type I transferrin isoform profile (HP:0003642)3.19056901
19Increased serum pyruvate (HP:0003542)3.17066602
20Abnormality of the preputium (HP:0100587)3.08595191
21Aplastic anemia (HP:0001915)3.07855078
22Meckel diverticulum (HP:0002245)3.02754268
23Abnormality of the labia minora (HP:0012880)2.97846099
24Absent thumb (HP:0009777)2.95332835
25Progressive macrocephaly (HP:0004481)2.93418988
26Hepatic necrosis (HP:0002605)2.91568032
27Abnormality of the ileum (HP:0001549)2.90303680
28Oral leukoplakia (HP:0002745)2.89629474
29Increased serum lactate (HP:0002151)2.82963009
30Patellar aplasia (HP:0006443)2.81428496
31Cerebral edema (HP:0002181)2.74871033
32Abnormality of chromosome stability (HP:0003220)2.74430134
33Aplasia/Hypoplasia of the patella (HP:0006498)2.69700050
34Aplasia/Hypoplasia of the uvula (HP:0010293)2.69380206
35Supernumerary spleens (HP:0009799)2.69084474
36Lipid accumulation in hepatocytes (HP:0006561)2.67036683
37Triphalangeal thumb (HP:0001199)2.60021830
38Rough bone trabeculation (HP:0100670)2.57259490
39Abnormal lung lobation (HP:0002101)2.56319461
40Colon cancer (HP:0003003)2.55566935
41Lactic acidosis (HP:0003128)2.54005565
42Selective tooth agenesis (HP:0001592)2.50578172
43Multiple enchondromatosis (HP:0005701)2.50240287
44Premature graying of hair (HP:0002216)2.49358258
45Medulloblastoma (HP:0002885)2.45421064
46Reduced antithrombin III activity (HP:0001976)2.43294384
47Abnormal number of incisors (HP:0011064)2.41294488
48Absent radius (HP:0003974)2.38032910
49Duplicated collecting system (HP:0000081)2.36878169
50Duodenal stenosis (HP:0100867)2.36692524
51Small intestinal stenosis (HP:0012848)2.36692524
52Ependymoma (HP:0002888)2.35338556
53Bone marrow hypocellularity (HP:0005528)2.34177079
54Cerebral hypomyelination (HP:0006808)2.32566830
55Myelodysplasia (HP:0002863)2.31822383
56Microretrognathia (HP:0000308)2.31385584
57Asplenia (HP:0001746)2.30765177
5811 pairs of ribs (HP:0000878)2.24709048
59Aplasia involving forearm bones (HP:0009822)2.24485714
60Absent forearm bone (HP:0003953)2.24485714
61Abnormality of the renal collecting system (HP:0004742)2.24376045
62Increased intramyocellular lipid droplets (HP:0012240)2.23223024
63Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.22993213
64IgM deficiency (HP:0002850)2.22082375
65Cleft eyelid (HP:0000625)2.20040637
66Hypoplasia of the radius (HP:0002984)2.19143910
67Pancytopenia (HP:0001876)2.18307023
68Agnosia (HP:0010524)2.18239124
69Neoplasm of the pancreas (HP:0002894)2.14243781
70Exercise intolerance (HP:0003546)2.14165010
71Carpal bone hypoplasia (HP:0001498)2.13904407
72Lymphoma (HP:0002665)2.13556158
73Abnormality of methionine metabolism (HP:0010901)2.12454832
74Tracheoesophageal fistula (HP:0002575)2.11207806
75Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.11186072
76Aplasia/Hypoplasia of the spleen (HP:0010451)2.10877110
77Trismus (HP:0000211)2.10816599
78Embryonal renal neoplasm (HP:0011794)2.09690043
79Degeneration of anterior horn cells (HP:0002398)2.08575480
80Abnormality of the anterior horn cell (HP:0006802)2.08575480
81Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.08364788
82Abnormal protein N-linked glycosylation (HP:0012347)2.08364788
83Abnormal protein glycosylation (HP:0012346)2.08364788
84Abnormal glycosylation (HP:0012345)2.08364788
85Hyperglycinemia (HP:0002154)2.08140837
863-Methylglutaconic aciduria (HP:0003535)2.07296620
87Abnormality of the carotid arteries (HP:0005344)2.05637515
88Cellular immunodeficiency (HP:0005374)2.03590042
89Neoplasm of the adrenal gland (HP:0100631)2.01403452
90Abnormality of alanine metabolism (HP:0010916)1.99992825
91Hyperalaninemia (HP:0003348)1.99992825
92Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.99992825
93Abnormality of DNA repair (HP:0003254)1.99688443
94Microvesicular hepatic steatosis (HP:0001414)1.99463256
95Horseshoe kidney (HP:0000085)1.98996990
96Abnormality of the duodenum (HP:0002246)1.98916697
97Muscle fiber atrophy (HP:0100295)1.98174243
98Thrombocytosis (HP:0001894)1.97761392
99Increased hepatocellular lipid droplets (HP:0006565)1.97560233
100Sex reversal (HP:0012245)1.96844785
101Abnormal sex determination (HP:0012244)1.96844785
102Ectopic kidney (HP:0000086)1.96602719
103Renal Fanconi syndrome (HP:0001994)1.96414349
104Neoplasm of the colon (HP:0100273)1.95082737
105Clubbing of toes (HP:0100760)1.94739777
106Abnormality of serum amino acid levels (HP:0003112)1.94593048
107Methylmalonic aciduria (HP:0012120)1.94214573
108Respiratory failure (HP:0002878)1.94200373
109Sloping forehead (HP:0000340)1.93988978
110Exertional dyspnea (HP:0002875)1.93121410
111Atresia of the external auditory canal (HP:0000413)1.93011697
112Abnormal trabecular bone morphology (HP:0100671)1.92522180
113Abdominal situs inversus (HP:0003363)1.92260032
114Abnormality of abdominal situs (HP:0011620)1.92260032
115Postnatal microcephaly (HP:0005484)1.90642476
116Optic nerve coloboma (HP:0000588)1.90285874
117Premature ovarian failure (HP:0008209)1.89568528
118Squamous cell carcinoma (HP:0002860)1.88892926
119Amaurosis fugax (HP:0100576)1.88370118
120Impulsivity (HP:0100710)1.86796396
121Glioma (HP:0009733)1.86553085
122Methylmalonic acidemia (HP:0002912)1.85580587
123Cholecystitis (HP:0001082)1.83770209
124Abnormal gallbladder physiology (HP:0012438)1.83770209
125Short thumb (HP:0009778)1.83577430
126Type 2 muscle fiber atrophy (HP:0003554)1.82781185
127Decreased activity of mitochondrial respiratory chain (HP:0008972)1.81665571
128Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.81665571
129Leukodystrophy (HP:0002415)1.80240170
130Lethargy (HP:0001254)1.79314518
131Respiratory difficulties (HP:0002880)1.77872467
132Progressive muscle weakness (HP:0003323)1.77738544
133Rhabdomyosarcoma (HP:0002859)1.77698790
134Nephroblastoma (Wilms tumor) (HP:0002667)1.77337615
135Duplication of thumb phalanx (HP:0009942)1.75734903
136Hypoplasia of the pons (HP:0012110)1.75446551
137IgG deficiency (HP:0004315)1.74829965
138Combined immunodeficiency (HP:0005387)1.74640710
139Secondary amenorrhea (HP:0000869)1.74338363
140Absent rod-and cone-mediated responses on ERG (HP:0007688)1.73591298
141CNS demyelination (HP:0007305)1.73039345
142Increased nuchal translucency (HP:0010880)1.72983576
143Severe visual impairment (HP:0001141)1.70479924
144Basal cell carcinoma (HP:0002671)1.69334296
145Abnormality of the heme biosynthetic pathway (HP:0010472)1.68586729
146Depressed nasal ridge (HP:0000457)1.68094727

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.62588367
2WEE13.63152056
3VRK23.62070101
4STK163.28535092
5CDC73.20430421
6NEK13.15265258
7NME23.06462742
8EIF2AK13.01323976
9TLK13.00566203
10SRPK12.85870786
11MKNK22.45268878
12MKNK12.44987033
13EIF2AK32.42179771
14VRK12.34992870
15TSSK62.16567360
16BCKDK2.10608898
17TRIM282.09087618
18NUAK12.03488302
19PLK42.01662504
20TESK22.01154451
21CLK11.91075191
22DYRK31.84550468
23NEK21.73818869
24MAP4K21.70959786
25ACVR1B1.69449200
26TTK1.67337108
27CDK71.66532898
28PASK1.62491831
29PLK11.51916511
30BRSK21.49488912
31TAF11.37062764
32IRAK41.36069901
33NLK1.35991289
34MAP4K11.34118903
35RPS6KB21.33769160
36AURKB1.33070658
37ATR1.28973017
38RPS6KA41.25508313
39BLK1.20746112
40AURKA1.18683186
41SCYL21.18365327
42PDK21.16914484
43EIF2AK21.16031439
44WNK31.13429147
45IRAK31.08591841
46TXK1.08251489
47KDR1.08002543
48YES11.07134894
49MST41.03770948
50CDK41.02661697
51PIM21.02078958
52CHEK21.01102411
53TGFBR11.00673106
54STK101.00434799
55TNIK0.97156780
56TEC0.97149734
57PBK0.95272054
58PLK30.95046511
59MAP3K80.93441722
60BMPR1B0.93288840
61CASK0.93061667
62PIM10.90941894
63ZAK0.90683149
64BTK0.89276826
65BCR0.88594807
66STK40.86179990
67CSNK1A1L0.82562418
68CDK80.81325111
69CDK190.81185404
70DAPK10.80918216
71MUSK0.78698742
72CHEK10.78026478
73RPS6KA50.77682878
74DYRK20.76994435
75CSNK1G20.76104553
76BRSK10.68460134
77EPHA20.67625068
78CSNK2A10.67563832
79CSNK2A20.66249112
80MAP3K110.64568860
81BRD40.63042994
82ERBB30.62165862
83PAK10.61907121
84ATM0.56983234
85PLK20.56295226
86SMG10.56231450
87PAK40.54621853
88ERBB40.53371357
89ZAP700.53090939
90CDK20.52940722
91IRAK10.52796189
92PRKD20.52731366
93ALK0.52608494
94NME10.52567391
95CCNB10.51315418
96MAP3K100.50675248
97BRAF0.50489928
98LYN0.50381909
99IKBKB0.48023544
100MAP2K70.47093972
101PRKCI0.45257410
102GRK60.45108612
103MAPKAPK30.44137652
104TAOK20.41776138
105CDK10.40113162
106IRAK20.39282792
107MAP3K120.34489795
108LCK0.34316915
109MAPKAPK50.31966004
110KIT0.31913187
111RAF10.31670171
112JAK30.31315616
113EEF2K0.31105274
114TESK10.30418912
115FLT30.30355072
116MAP3K40.30184187
117CSNK1G10.29878585
118PRKDC0.28873855
119LRRK20.27976408
120FGFR10.26974054
121CSNK1E0.26126966
122CDK30.25544859
123STK30.25112506
124UHMK10.25096574
125HIPK20.24911332
126SYK0.24882239
127CDK180.24346029
128CSNK1G30.23953255
129OXSR10.23888155
130AKT20.23873060
131CDK60.23382973
132CDK120.23253749
133STK38L0.22402571
134CDK140.20561207
135CDK11A0.18630194

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.91364167
2Ribosome_Homo sapiens_hsa030104.40168981
3Mismatch repair_Homo sapiens_hsa034303.97066386
4* Spliceosome_Homo sapiens_hsa030403.26780300
5RNA polymerase_Homo sapiens_hsa030203.19380450
6Homologous recombination_Homo sapiens_hsa034403.19083589
7Proteasome_Homo sapiens_hsa030503.15985921
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.07020899
9Base excision repair_Homo sapiens_hsa034103.00138360
10Nucleotide excision repair_Homo sapiens_hsa034202.79342548
11Pyrimidine metabolism_Homo sapiens_hsa002402.47868984
12RNA transport_Homo sapiens_hsa030132.47416478
13Fanconi anemia pathway_Homo sapiens_hsa034602.42043589
14Cell cycle_Homo sapiens_hsa041102.23435671
15One carbon pool by folate_Homo sapiens_hsa006702.18002888
16Basal transcription factors_Homo sapiens_hsa030222.06499700
17Non-homologous end-joining_Homo sapiens_hsa034502.04350610
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.77254069
19RNA degradation_Homo sapiens_hsa030181.77197740
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.72746797
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.61807771
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.60691722
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.57971040
24Fatty acid elongation_Homo sapiens_hsa000621.51172215
25Protein export_Homo sapiens_hsa030601.48170082
26Biosynthesis of amino acids_Homo sapiens_hsa012301.41947404
27p53 signaling pathway_Homo sapiens_hsa041151.40812631
28mRNA surveillance pathway_Homo sapiens_hsa030151.39891271
29Purine metabolism_Homo sapiens_hsa002301.36155938
30Propanoate metabolism_Homo sapiens_hsa006401.33550969
31Pyruvate metabolism_Homo sapiens_hsa006201.26503835
32Carbon metabolism_Homo sapiens_hsa012001.21446558
33Primary immunodeficiency_Homo sapiens_hsa053401.20713943
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.17508049
35Systemic lupus erythematosus_Homo sapiens_hsa053221.17488932
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.16162351
37Epstein-Barr virus infection_Homo sapiens_hsa051691.15194537
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.08409067
39Antigen processing and presentation_Homo sapiens_hsa046121.06649217
40Herpes simplex infection_Homo sapiens_hsa051681.05788189
41Steroid biosynthesis_Homo sapiens_hsa001001.01089905
42Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.93552150
43Sulfur relay system_Homo sapiens_hsa041220.84156063
44Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.81853460
45Vitamin B6 metabolism_Homo sapiens_hsa007500.81413841
46Folate biosynthesis_Homo sapiens_hsa007900.80294770
47Thyroid cancer_Homo sapiens_hsa052160.80034193
48Viral carcinogenesis_Homo sapiens_hsa052030.76362450
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76107923
50Graft-versus-host disease_Homo sapiens_hsa053320.75688428
51Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75553738
52Huntingtons disease_Homo sapiens_hsa050160.75452585
53NF-kappa B signaling pathway_Homo sapiens_hsa040640.75427857
54Measles_Homo sapiens_hsa051620.74426356
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72255638
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72183162
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71791847
58HTLV-I infection_Homo sapiens_hsa051660.66498808
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.66111876
60Parkinsons disease_Homo sapiens_hsa050120.65239583
61Allograft rejection_Homo sapiens_hsa053300.64828334
62Intestinal immune network for IgA production_Homo sapiens_hsa046720.62990122
63Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61180338
64Oxidative phosphorylation_Homo sapiens_hsa001900.60996559
65Basal cell carcinoma_Homo sapiens_hsa052170.60524237
66Hematopoietic cell lineage_Homo sapiens_hsa046400.59873697
67Butanoate metabolism_Homo sapiens_hsa006500.55579772
68Asthma_Homo sapiens_hsa053100.54833480
69Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.54106135
70Peroxisome_Homo sapiens_hsa041460.53455408
71Legionellosis_Homo sapiens_hsa051340.53298417
72Sulfur metabolism_Homo sapiens_hsa009200.52387729
73Oocyte meiosis_Homo sapiens_hsa041140.50990838
74Pentose phosphate pathway_Homo sapiens_hsa000300.49210495
75Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.49081615
76Fatty acid metabolism_Homo sapiens_hsa012120.48577724
77Other glycan degradation_Homo sapiens_hsa005110.46502337
78Apoptosis_Homo sapiens_hsa042100.46383968
79RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.45671626
80Alcoholism_Homo sapiens_hsa050340.45279001
81Arachidonic acid metabolism_Homo sapiens_hsa005900.43411753
82N-Glycan biosynthesis_Homo sapiens_hsa005100.42492444
83Autoimmune thyroid disease_Homo sapiens_hsa053200.42220527
84NOD-like receptor signaling pathway_Homo sapiens_hsa046210.42179076
85Small cell lung cancer_Homo sapiens_hsa052220.41298624
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39862387
87Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39684614
88MicroRNAs in cancer_Homo sapiens_hsa052060.38413839
89Glutathione metabolism_Homo sapiens_hsa004800.37517702
90Shigellosis_Homo sapiens_hsa051310.36806268
91Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.36777340
92Arginine and proline metabolism_Homo sapiens_hsa003300.36556210
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.34458334
94Hepatitis B_Homo sapiens_hsa051610.34316629
95Colorectal cancer_Homo sapiens_hsa052100.34233868
96Acute myeloid leukemia_Homo sapiens_hsa052210.32621622
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32350522
98Drug metabolism - other enzymes_Homo sapiens_hsa009830.31454365
99Leishmaniasis_Homo sapiens_hsa051400.30798742
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29859916
101Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.29012806
102T cell receptor signaling pathway_Homo sapiens_hsa046600.28770519
103Cysteine and methionine metabolism_Homo sapiens_hsa002700.28547564
104Notch signaling pathway_Homo sapiens_hsa043300.28355647
105Jak-STAT signaling pathway_Homo sapiens_hsa046300.28318329
106Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.28169394
107Pathways in cancer_Homo sapiens_hsa052000.27756110
108Influenza A_Homo sapiens_hsa051640.27613382
109Wnt signaling pathway_Homo sapiens_hsa043100.26866632
110Fructose and mannose metabolism_Homo sapiens_hsa000510.26326011
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.26002598
112Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.25797786
113Pentose and glucuronate interconversions_Homo sapiens_hsa000400.25482973
114Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.24811402
115Sphingolipid metabolism_Homo sapiens_hsa006000.24400761
116TGF-beta signaling pathway_Homo sapiens_hsa043500.24307809
117Phototransduction_Homo sapiens_hsa047440.23033790
118Ether lipid metabolism_Homo sapiens_hsa005650.22341226
119Hedgehog signaling pathway_Homo sapiens_hsa043400.21782924
120Alzheimers disease_Homo sapiens_hsa050100.20726457
121Metabolic pathways_Homo sapiens_hsa011000.20628759
122Galactose metabolism_Homo sapiens_hsa000520.20496579
123Hippo signaling pathway_Homo sapiens_hsa043900.20319226
124Linoleic acid metabolism_Homo sapiens_hsa005910.20047428
125Regulation of autophagy_Homo sapiens_hsa041400.20025143
126Cardiac muscle contraction_Homo sapiens_hsa042600.19120690
127Selenocompound metabolism_Homo sapiens_hsa004500.17133362
128Prostate cancer_Homo sapiens_hsa052150.16639850
129Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.16382286
130beta-Alanine metabolism_Homo sapiens_hsa004100.16350132
131Fatty acid degradation_Homo sapiens_hsa000710.15754131
132Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.15384188
133Lysine degradation_Homo sapiens_hsa003100.13855803
134Tryptophan metabolism_Homo sapiens_hsa003800.09791854
135Vitamin digestion and absorption_Homo sapiens_hsa049770.07341361
136Nitrogen metabolism_Homo sapiens_hsa009100.06795467
137Arginine biosynthesis_Homo sapiens_hsa00220-0.0158474
138Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603-0.0023329

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