

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 5.15021163 |
| 2 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.89724807 |
| 3 | telomere maintenance via semi-conservative replication (GO:0032201) | 4.72013632 |
| 4 | ribosomal small subunit assembly (GO:0000028) | 4.71653551 |
| 5 | DNA strand elongation (GO:0022616) | 4.66493390 |
| 6 | chaperone-mediated protein transport (GO:0072321) | 4.61310278 |
| 7 | DNA replication initiation (GO:0006270) | 4.58428207 |
| 8 | DNA deamination (GO:0045006) | 4.57165283 |
| 9 | ATP synthesis coupled proton transport (GO:0015986) | 4.51645925 |
| 10 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.51645925 |
| 11 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.50519114 |
| 12 | maturation of SSU-rRNA (GO:0030490) | 4.45310988 |
| 13 | nucleobase biosynthetic process (GO:0046112) | 4.43867537 |
| 14 | purine nucleobase biosynthetic process (GO:0009113) | 4.33992220 |
| 15 | formation of translation preinitiation complex (GO:0001731) | 4.33100502 |
| 16 | telomere maintenance via recombination (GO:0000722) | 4.26876672 |
| 17 | CENP-A containing nucleosome assembly (GO:0034080) | 4.23091365 |
| 18 | DNA replication checkpoint (GO:0000076) | 4.21393802 |
| 19 | proteasome assembly (GO:0043248) | 4.13627498 |
| 20 | chromatin remodeling at centromere (GO:0031055) | 4.13221615 |
| 21 | ribosomal large subunit biogenesis (GO:0042273) | 4.06944391 |
| 22 | DNA unwinding involved in DNA replication (GO:0006268) | 4.01463985 |
| 23 | mitotic recombination (GO:0006312) | 4.00832803 |
| 24 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.99782753 |
| 25 | mitotic metaphase plate congression (GO:0007080) | 3.99316113 |
| 26 | regulation of mitochondrial translation (GO:0070129) | 3.89281512 |
| 27 | ribosome biogenesis (GO:0042254) | 3.88316104 |
| 28 | IMP biosynthetic process (GO:0006188) | 3.85785278 |
| 29 | respiratory electron transport chain (GO:0022904) | 3.81751551 |
| 30 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.79240161 |
| 31 | ribosome assembly (GO:0042255) | 3.78651004 |
| 32 | telomere maintenance via telomere lengthening (GO:0010833) | 3.78393565 |
| 33 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.77014569 |
| 34 | DNA replication-independent nucleosome organization (GO:0034724) | 3.75515523 |
| 35 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.75515523 |
| 36 | protein localization to kinetochore (GO:0034501) | 3.75093315 |
| 37 | electron transport chain (GO:0022900) | 3.73045180 |
| 38 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.69432288 |
| 39 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.67008061 |
| 40 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.65025270 |
| 41 | DNA damage response, detection of DNA damage (GO:0042769) | 3.64243742 |
| 42 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.64111282 |
| 43 | spliceosomal snRNP assembly (GO:0000387) | 3.62214319 |
| 44 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.61138324 |
| 45 | viral transcription (GO:0019083) | 3.60492847 |
| 46 | translational termination (GO:0006415) | 3.59710103 |
| 47 | kinetochore organization (GO:0051383) | 3.58724073 |
| 48 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.55970651 |
| 49 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.55933103 |
| 50 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.55933103 |
| 51 | cullin deneddylation (GO:0010388) | 3.54634815 |
| 52 | protein targeting to mitochondrion (GO:0006626) | 3.53708503 |
| 53 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.52983681 |
| 54 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.52983681 |
| 55 | NADH dehydrogenase complex assembly (GO:0010257) | 3.52983681 |
| 56 | mitotic nuclear envelope disassembly (GO:0007077) | 3.52530590 |
| 57 | protein complex biogenesis (GO:0070271) | 3.52099370 |
| 58 | rRNA processing (GO:0006364) | 3.50110279 |
| 59 | ribosomal small subunit biogenesis (GO:0042274) | 3.47389901 |
| 60 | pseudouridine synthesis (GO:0001522) | 3.47039178 |
| 61 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.46919658 |
| 62 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.46780726 |
| 63 | metaphase plate congression (GO:0051310) | 3.46591353 |
| 64 | respiratory chain complex IV assembly (GO:0008535) | 3.45011370 |
| 65 | histone exchange (GO:0043486) | 3.44020512 |
| 66 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.40775520 |
| 67 | negative regulation of ligase activity (GO:0051352) | 3.40775520 |
| 68 | translational initiation (GO:0006413) | 3.40174896 |
| 69 | rRNA modification (GO:0000154) | 3.39367923 |
| 70 | translational elongation (GO:0006414) | 3.39075774 |
| 71 | rRNA metabolic process (GO:0016072) | 3.38515629 |
| 72 | kinetochore assembly (GO:0051382) | 3.38470938 |
| 73 | protein deneddylation (GO:0000338) | 3.37439083 |
| 74 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.37145592 |
| 75 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.36271782 |
| 76 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.36271782 |
| 77 | protein neddylation (GO:0045116) | 3.35868453 |
| 78 | IMP metabolic process (GO:0046040) | 3.34175564 |
| 79 | G1/S transition of mitotic cell cycle (GO:0000082) | 3.28465183 |
| 80 | cell cycle G1/S phase transition (GO:0044843) | 3.28465183 |
| 81 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.27456918 |
| 82 | establishment of protein localization to mitochondrion (GO:0072655) | 3.26801122 |
| 83 | protein localization to mitochondrion (GO:0070585) | 3.26641962 |
| 84 | termination of RNA polymerase III transcription (GO:0006386) | 3.26613999 |
| 85 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.26613999 |
| 86 | protein localization to chromosome, centromeric region (GO:0071459) | 3.25959453 |
| 87 | attachment of spindle microtubules to kinetochore (GO:0008608) | 3.24848029 |
| 88 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.24016488 |
| 89 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.24016488 |
| 90 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.23193046 |
| 91 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.23193046 |
| 92 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.23193046 |
| 93 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.22208659 |
| 94 | nuclear envelope disassembly (GO:0051081) | 3.21663339 |
| 95 | membrane disassembly (GO:0030397) | 3.21663339 |
| 96 | histone mRNA metabolic process (GO:0008334) | 3.21215820 |
| 97 | maturation of 5.8S rRNA (GO:0000460) | 3.20882016 |
| 98 | establishment of chromosome localization (GO:0051303) | 3.18941603 |
| 99 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.18660698 |
| 100 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.17992637 |
| 101 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.17992637 |
| 102 | viral mRNA export from host cell nucleus (GO:0046784) | 3.17782537 |
| 103 | oxidative phosphorylation (GO:0006119) | 3.16427601 |
| 104 | establishment of integrated proviral latency (GO:0075713) | 3.16142290 |
| 105 | establishment of viral latency (GO:0019043) | 3.15659787 |
| 106 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.14966166 |
| 107 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.14556253 |
| 108 | DNA double-strand break processing (GO:0000729) | 3.10315704 |
| 109 | spliceosomal complex assembly (GO:0000245) | 3.09929474 |
| 110 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.09427146 |
| 111 | cytochrome complex assembly (GO:0017004) | 3.08613936 |
| 112 | mitochondrial RNA metabolic process (GO:0000959) | 3.08248301 |
| 113 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.07978956 |
| 114 | transcription from mitochondrial promoter (GO:0006390) | 3.07574562 |
| 115 | 7-methylguanosine mRNA capping (GO:0006370) | 3.07179604 |
| 116 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.07046550 |
| 117 | translation (GO:0006412) | 3.06926424 |
| 118 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.05842153 |
| 119 | cotranslational protein targeting to membrane (GO:0006613) | 3.05454360 |
| 120 | positive regulation of ligase activity (GO:0051351) | 3.03881465 |
| 121 | protein targeting to ER (GO:0045047) | 3.03610697 |
| 122 | 7-methylguanosine RNA capping (GO:0009452) | 3.01581308 |
| 123 | RNA capping (GO:0036260) | 3.01581308 |
| 124 | regulation of double-strand break repair via homologous recombination (GO:0010569) | 3.01285681 |
| 125 | nuclear pore organization (GO:0006999) | 3.00607245 |
| 126 | cellular component biogenesis (GO:0044085) | 3.00409989 |
| 127 | deoxyribonucleotide biosynthetic process (GO:0009263) | 2.98588468 |
| 128 | telomere organization (GO:0032200) | 2.96199975 |
| 129 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 2.95768351 |
| 130 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 2.95574814 |
| 131 | telomere maintenance (GO:0000723) | 2.95341606 |
| 132 | negative regulation of sister chromatid segregation (GO:0033046) | 2.90448090 |
| 133 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 2.90448090 |
| 134 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 2.90448090 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 8.10789967 |
| 2 | * MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.47263638 |
| 3 | * EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.86919463 |
| 4 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.69075341 |
| 5 | * E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.53009294 |
| 6 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 3.34741782 |
| 7 | * EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.32042267 |
| 8 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.26774739 |
| 9 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.22398068 |
| 10 | * ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.05112608 |
| 11 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 3.00329021 |
| 12 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.99512209 |
| 13 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.98904088 |
| 14 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.94913209 |
| 15 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.91361952 |
| 16 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.69126990 |
| 17 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.60257614 |
| 18 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.45406813 |
| 19 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.44150546 |
| 20 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.41994003 |
| 21 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.39991028 |
| 22 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.33653298 |
| 23 | * E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.16465523 |
| 24 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.13821371 |
| 25 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.11722036 |
| 26 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.11175075 |
| 27 | * FOXP3_21729870_ChIP-Seq_TREG_Human | 2.10014619 |
| 28 | GABP_19822575_ChIP-Seq_HepG2_Human | 2.02697469 |
| 29 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.02230880 |
| 30 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.00485105 |
| 31 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.99988986 |
| 32 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.97208399 |
| 33 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.94669183 |
| 34 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.93446397 |
| 35 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.88959722 |
| 36 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.88035128 |
| 37 | * E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.86744979 |
| 38 | * MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.83067211 |
| 39 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.78944842 |
| 40 | * ELK1_19687146_ChIP-ChIP_HELA_Human | 1.76200849 |
| 41 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.74882487 |
| 42 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.72845943 |
| 43 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.72124377 |
| 44 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.67592058 |
| 45 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.67129648 |
| 46 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.65945920 |
| 47 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.63926361 |
| 48 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.61028712 |
| 49 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.57803642 |
| 50 | * ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.57407757 |
| 51 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.53686213 |
| 52 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.53280024 |
| 53 | * KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.51497194 |
| 54 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.51485199 |
| 55 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.44048709 |
| 56 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.42863326 |
| 57 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.36162331 |
| 58 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.33886799 |
| 59 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.32639311 |
| 60 | * ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.31702539 |
| 61 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.29127201 |
| 62 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.27753272 |
| 63 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.26452903 |
| 64 | MYC_22102868_ChIP-Seq_BL_Human | 1.25186888 |
| 65 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.23147527 |
| 66 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.22463229 |
| 67 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.21687960 |
| 68 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.17941953 |
| 69 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.16610016 |
| 70 | EWS_26573619_Chip-Seq_HEK293_Human | 1.13871210 |
| 71 | * E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.13360581 |
| 72 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.11398512 |
| 73 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.10520891 |
| 74 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.10455880 |
| 75 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.08258434 |
| 76 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.07671880 |
| 77 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.06920942 |
| 78 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.06614742 |
| 79 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.06387486 |
| 80 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.04947413 |
| 81 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.03636545 |
| 82 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.03044381 |
| 83 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.02384008 |
| 84 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.02343712 |
| 85 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.02281953 |
| 86 | * HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.02036294 |
| 87 | * CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.98824474 |
| 88 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.96865385 |
| 89 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.95629815 |
| 90 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.95255209 |
| 91 | * GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.94591956 |
| 92 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 0.92338276 |
| 93 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 0.91211551 |
| 94 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.89738019 |
| 95 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.88917861 |
| 96 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.88080732 |
| 97 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.86231266 |
| 98 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.86093168 |
| 99 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 0.84914343 |
| 100 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.83774981 |
| 101 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.81731901 |
| 102 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.78293747 |
| 103 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 0.78230571 |
| 104 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 0.77599796 |
| 105 | FUS_26573619_Chip-Seq_HEK293_Human | 0.77270425 |
| 106 | * FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.75592628 |
| 107 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.74168160 |
| 108 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.71618830 |
| 109 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.69290072 |
| 110 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.69272536 |
| 111 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.67623943 |
| 112 | VDR_22108803_ChIP-Seq_LS180_Human | 0.66031319 |
| 113 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.64705646 |
| 114 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 0.64541993 |
| 115 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 0.64398342 |
| 116 | * FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.63524976 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 5.86027394 |
| 2 | MP0010094_abnormal_chromosome_stability | 4.82943087 |
| 3 | MP0004957_abnormal_blastocyst_morpholog | 4.61174651 |
| 4 | MP0003111_abnormal_nucleus_morphology | 4.45739195 |
| 5 | MP0003077_abnormal_cell_cycle | 4.16828910 |
| 6 | MP0008057_abnormal_DNA_replication | 3.74946680 |
| 7 | MP0008058_abnormal_DNA_repair | 3.73423073 |
| 8 | MP0008007_abnormal_cellular_replicative | 3.24043202 |
| 9 | MP0008932_abnormal_embryonic_tissue | 2.82122875 |
| 10 | MP0002396_abnormal_hematopoietic_system | 2.62504373 |
| 11 | MP0003123_paternal_imprinting | 2.47615857 |
| 12 | MP0001730_embryonic_growth_arrest | 2.30042882 |
| 13 | MP0003786_premature_aging | 2.27211369 |
| 14 | MP0000350_abnormal_cell_proliferation | 2.17362841 |
| 15 | MP0001529_abnormal_vocalization | 2.09121085 |
| 16 | MP0008877_abnormal_DNA_methylation | 2.08793749 |
| 17 | MP0010352_gastrointestinal_tract_polyps | 2.03197395 |
| 18 | MP0000490_abnormal_crypts_of | 1.80486465 |
| 19 | MP0003718_maternal_effect | 1.79949200 |
| 20 | MP0001697_abnormal_embryo_size | 1.62810531 |
| 21 | MP0003806_abnormal_nucleotide_metabolis | 1.60572320 |
| 22 | MP0005380_embryogenesis_phenotype | 1.56588434 |
| 23 | MP0001672_abnormal_embryogenesis/_devel | 1.56588434 |
| 24 | MP0010307_abnormal_tumor_latency | 1.54688304 |
| 25 | MP0000313_abnormal_cell_death | 1.54236591 |
| 26 | MP0002102_abnormal_ear_morphology | 1.50495999 |
| 27 | MP0002080_prenatal_lethality | 1.49549438 |
| 28 | MP0004808_abnormal_hematopoietic_stem | 1.48119308 |
| 29 | MP0002019_abnormal_tumor_incidence | 1.46605512 |
| 30 | MP0009333_abnormal_splenocyte_physiolog | 1.45136415 |
| 31 | MP0000372_irregular_coat_pigmentation | 1.43816142 |
| 32 | MP0003984_embryonic_growth_retardation | 1.41242084 |
| 33 | MP0006072_abnormal_retinal_apoptosis | 1.40278144 |
| 34 | MP0008789_abnormal_olfactory_epithelium | 1.40023672 |
| 35 | MP0003186_abnormal_redox_activity | 1.38457077 |
| 36 | MP0001188_hyperpigmentation | 1.37720599 |
| 37 | MP0002088_abnormal_embryonic_growth/wei | 1.36841799 |
| 38 | MP0003763_abnormal_thymus_physiology | 1.34330598 |
| 39 | MP0003315_abnormal_perineum_morphology | 1.33205707 |
| 40 | MP0002085_abnormal_embryonic_tissue | 1.30811884 |
| 41 | MP0002736_abnormal_nociception_after | 1.30419332 |
| 42 | MP0010030_abnormal_orbit_morphology | 1.29802384 |
| 43 | MP0002163_abnormal_gland_morphology | 1.27350594 |
| 44 | MP0006292_abnormal_olfactory_placode | 1.23167589 |
| 45 | MP0003121_genomic_imprinting | 1.22441508 |
| 46 | MP0002210_abnormal_sex_determination | 1.21066005 |
| 47 | MP0005397_hematopoietic_system_phenotyp | 1.19488960 |
| 48 | MP0001545_abnormal_hematopoietic_system | 1.19488960 |
| 49 | MP0002086_abnormal_extraembryonic_tissu | 1.18333941 |
| 50 | MP0002398_abnormal_bone_marrow | 1.17758077 |
| 51 | MP0001293_anophthalmia | 1.17303634 |
| 52 | MP0003567_abnormal_fetal_cardiomyocyte | 1.13841121 |
| 53 | MP0004197_abnormal_fetal_growth/weight/ | 1.13640252 |
| 54 | MP0000703_abnormal_thymus_morphology | 1.13245327 |
| 55 | MP0002132_abnormal_respiratory_system | 1.12149477 |
| 56 | MP0002722_abnormal_immune_system | 1.10876085 |
| 57 | MP0002084_abnormal_developmental_patter | 1.10702015 |
| 58 | MP0009697_abnormal_copulation | 1.10628031 |
| 59 | MP0005499_abnormal_olfactory_system | 1.09447046 |
| 60 | MP0005394_taste/olfaction_phenotype | 1.09447046 |
| 61 | MP0000689_abnormal_spleen_morphology | 1.09253249 |
| 62 | MP0002160_abnormal_reproductive_system | 1.05437476 |
| 63 | MP0003890_abnormal_embryonic-extraembry | 1.04099311 |
| 64 | MP0001145_abnormal_male_reproductive | 1.02028499 |
| 65 | MP0002277_abnormal_respiratory_mucosa | 0.99012939 |
| 66 | MP0001835_abnormal_antigen_presentation | 0.98785357 |
| 67 | MP0000358_abnormal_cell_content/ | 0.97848971 |
| 68 | MP0003937_abnormal_limbs/digits/tail_de | 0.97524790 |
| 69 | MP0005389_reproductive_system_phenotype | 0.96613046 |
| 70 | MP0001853_heart_inflammation | 0.96059742 |
| 71 | MP0002429_abnormal_blood_cell | 0.95010256 |
| 72 | MP0005084_abnormal_gallbladder_morpholo | 0.94928445 |
| 73 | MP0000858_altered_metastatic_potential | 0.94785108 |
| 74 | MP0001119_abnormal_female_reproductive | 0.92815347 |
| 75 | MP0009379_abnormal_foot_pigmentation | 0.92134727 |
| 76 | MP0006036_abnormal_mitochondrial_physio | 0.90781000 |
| 77 | MP0000049_abnormal_middle_ear | 0.89691793 |
| 78 | MP0002751_abnormal_autonomic_nervous | 0.89473922 |
| 79 | MP0001929_abnormal_gametogenesis | 0.87684121 |
| 80 | MP0000653_abnormal_sex_gland | 0.87516704 |
| 81 | MP0006035_abnormal_mitochondrial_morpho | 0.85475679 |
| 82 | MP0005671_abnormal_response_to | 0.85373621 |
| 83 | MP0002938_white_spotting | 0.83930514 |
| 84 | MP0005075_abnormal_melanosome_morpholog | 0.82914088 |
| 85 | MP0003941_abnormal_skin_development | 0.82566500 |
| 86 | MP0002095_abnormal_skin_pigmentation | 0.81682733 |
| 87 | MP0001919_abnormal_reproductive_system | 0.81663402 |
| 88 | MP0000716_abnormal_immune_system | 0.81574510 |
| 89 | MP0006054_spinal_hemorrhage | 0.80696017 |
| 90 | MP0009053_abnormal_anal_canal | 0.80574603 |
| 91 | MP0004147_increased_porphyrin_level | 0.80332329 |
| 92 | MP0003136_yellow_coat_color | 0.79194943 |
| 93 | MP0008872_abnormal_physiological_respon | 0.78444584 |
| 94 | MP0005384_cellular_phenotype | 0.78005685 |
| 95 | MP0000631_abnormal_neuroendocrine_gland | 0.77723995 |
| 96 | MP0004133_heterotaxia | 0.75410232 |
| 97 | MP0001881_abnormal_mammary_gland | 0.73181213 |
| 98 | MP0003698_abnormal_male_reproductive | 0.72858692 |
| 99 | MP0003011_delayed_dark_adaptation | 0.70657991 |
| 100 | MP0001800_abnormal_humoral_immune | 0.70216314 |
| 101 | MP0002254_reproductive_system_inflammat | 0.69867778 |
| 102 | MP0003119_abnormal_digestive_system | 0.69322708 |
| 103 | MP0002420_abnormal_adaptive_immunity | 0.68343590 |
| 104 | MP0001819_abnormal_immune_cell | 0.67703672 |
| 105 | MP0003787_abnormal_imprinting | 0.67551749 |
| 106 | MP0003221_abnormal_cardiomyocyte_apopto | 0.67546139 |
| 107 | MP0002452_abnormal_antigen_presenting | 0.67228645 |
| 108 | MP0001727_abnormal_embryo_implantation | 0.66816699 |
| 109 | MP0005621_abnormal_cell_physiology | 0.64403341 |
| 110 | MP0000015_abnormal_ear_pigmentation | 0.64002251 |
| 111 | MP0002111_abnormal_tail_morphology | 0.63528765 |
| 112 | MP0003880_abnormal_central_pattern | 0.61816712 |
| 113 | MP0005379_endocrine/exocrine_gland_phen | 0.61599003 |
| 114 | MP0005253_abnormal_eye_physiology | 0.60735222 |
| 115 | MP0001764_abnormal_homeostasis | 0.59855445 |
| 116 | MP0009785_altered_susceptibility_to | 0.59566298 |
| 117 | MP0001968_abnormal_touch/_nociception | 0.59255008 |
| 118 | MP0002234_abnormal_pharynx_morphology | 0.59209549 |
| 119 | MP0005645_abnormal_hypothalamus_physiol | 0.58910486 |
| 120 | MP0000685_abnormal_immune_system | 0.58863748 |
| 121 | MP0002405_respiratory_system_inflammati | 0.58691546 |
| 122 | MP0005023_abnormal_wound_healing | 0.58172732 |
| 123 | MP0001984_abnormal_olfaction | 0.57562495 |
| 124 | MP0002233_abnormal_nose_morphology | 0.57489081 |
| 125 | MP0000465_gastrointestinal_hemorrhage | 0.57387988 |
| 126 | MP0002723_abnormal_immune_serum | 0.56498479 |
| 127 | MP0009672_abnormal_birth_weight | 0.56459614 |
| 128 | MP0002161_abnormal_fertility/fecundity | 0.56350906 |
| 129 | MP0005408_hypopigmentation | 0.56047775 |
| 130 | MP0009046_muscle_twitch | 0.55920627 |
| 131 | MP0000477_abnormal_intestine_morphology | 0.55585918 |
| 132 | MP0008995_early_reproductive_senescence | 0.55521232 |
| 133 | MP0000537_abnormal_urethra_morphology | 0.55467388 |
| 134 | MP0000647_abnormal_sebaceous_gland | 0.55363616 |
| 135 | MP0001286_abnormal_eye_development | 0.55319340 |
| 136 | MP0004142_abnormal_muscle_tone | 0.54896369 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Birth length less than 3rd percentile (HP:0003561) | 5.24381911 |
| 2 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.72681968 |
| 3 | Acute encephalopathy (HP:0006846) | 4.52025680 |
| 4 | Reticulocytopenia (HP:0001896) | 4.24944297 |
| 5 | Abnormality of cells of the erythroid lineage (HP:0012130) | 4.12910924 |
| 6 | Progressive macrocephaly (HP:0004481) | 4.09943245 |
| 7 | Breast hypoplasia (HP:0003187) | 4.01479808 |
| 8 | Increased hepatocellular lipid droplets (HP:0006565) | 3.90133524 |
| 9 | Abnormal number of erythroid precursors (HP:0012131) | 3.86843884 |
| 10 | Oral leukoplakia (HP:0002745) | 3.86340588 |
| 11 | Chromsome breakage (HP:0040012) | 3.68077703 |
| 12 | Colon cancer (HP:0003003) | 3.59012140 |
| 13 | Cerebral edema (HP:0002181) | 3.50558388 |
| 14 | Lipid accumulation in hepatocytes (HP:0006561) | 3.49148892 |
| 15 | Aplastic anemia (HP:0001915) | 3.48456612 |
| 16 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 3.46448963 |
| 17 | Hepatic necrosis (HP:0002605) | 3.42101849 |
| 18 | Carpal bone hypoplasia (HP:0001498) | 3.40359344 |
| 19 | Degeneration of anterior horn cells (HP:0002398) | 3.33520246 |
| 20 | Abnormality of the anterior horn cell (HP:0006802) | 3.33520246 |
| 21 | Patellar aplasia (HP:0006443) | 3.31102597 |
| 22 | Rough bone trabeculation (HP:0100670) | 3.30107253 |
| 23 | Selective tooth agenesis (HP:0001592) | 3.17798187 |
| 24 | Meckel diverticulum (HP:0002245) | 3.15894500 |
| 25 | Aplasia/Hypoplasia of the patella (HP:0006498) | 3.13690396 |
| 26 | Cerebral hypomyelination (HP:0006808) | 3.09006132 |
| 27 | Abnormality of the preputium (HP:0100587) | 3.04545545 |
| 28 | Abnormality of chromosome stability (HP:0003220) | 3.01764766 |
| 29 | Abnormality of the ileum (HP:0001549) | 2.98933825 |
| 30 | Microretrognathia (HP:0000308) | 2.95588594 |
| 31 | Macrocytic anemia (HP:0001972) | 2.89533622 |
| 32 | Increased intramyocellular lipid droplets (HP:0012240) | 2.89149525 |
| 33 | Lactic acidosis (HP:0003128) | 2.87760198 |
| 34 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.85567083 |
| 35 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.85567083 |
| 36 | Renal Fanconi syndrome (HP:0001994) | 2.85032414 |
| 37 | Medulloblastoma (HP:0002885) | 2.83500797 |
| 38 | Absent thumb (HP:0009777) | 2.79042050 |
| 39 | Premature graying of hair (HP:0002216) | 2.75625583 |
| 40 | Pallor (HP:0000980) | 2.74118243 |
| 41 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.65886071 |
| 42 | Exercise intolerance (HP:0003546) | 2.61032701 |
| 43 | Agnosia (HP:0010524) | 2.55083425 |
| 44 | Myelodysplasia (HP:0002863) | 2.54265985 |
| 45 | 11 pairs of ribs (HP:0000878) | 2.53794925 |
| 46 | Bone marrow hypocellularity (HP:0005528) | 2.52073349 |
| 47 | Respiratory failure (HP:0002878) | 2.51367985 |
| 48 | Leukodystrophy (HP:0002415) | 2.48578016 |
| 49 | Small intestinal stenosis (HP:0012848) | 2.48543854 |
| 50 | Duodenal stenosis (HP:0100867) | 2.48543854 |
| 51 | Respiratory difficulties (HP:0002880) | 2.44159244 |
| 52 | Cellular immunodeficiency (HP:0005374) | 2.44113507 |
| 53 | Poor head control (HP:0002421) | 2.43513447 |
| 54 | Abnormal lung lobation (HP:0002101) | 2.43095113 |
| 55 | Microvesicular hepatic steatosis (HP:0001414) | 2.41521580 |
| 56 | Absent radius (HP:0003974) | 2.40178753 |
| 57 | Increased serum lactate (HP:0002151) | 2.39780249 |
| 58 | Exertional dyspnea (HP:0002875) | 2.38468798 |
| 59 | Abnormal trabecular bone morphology (HP:0100671) | 2.37626035 |
| 60 | Trismus (HP:0000211) | 2.37292036 |
| 61 | Neoplasm of the pancreas (HP:0002894) | 2.36681136 |
| 62 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 2.35596318 |
| 63 | Optic disc pallor (HP:0000543) | 2.31679605 |
| 64 | Type I transferrin isoform profile (HP:0003642) | 2.30797947 |
| 65 | Abnormal number of incisors (HP:0011064) | 2.30529628 |
| 66 | Pancytopenia (HP:0001876) | 2.29386000 |
| 67 | Increased muscle lipid content (HP:0009058) | 2.28418385 |
| 68 | Horseshoe kidney (HP:0000085) | 2.27471468 |
| 69 | Impulsivity (HP:0100710) | 2.27321715 |
| 70 | Thrombocytosis (HP:0001894) | 2.27172301 |
| 71 | Abnormality of methionine metabolism (HP:0010901) | 2.26374222 |
| 72 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.26308289 |
| 73 | Methylmalonic acidemia (HP:0002912) | 2.24587921 |
| 74 | Abnormal protein glycosylation (HP:0012346) | 2.24325495 |
| 75 | Abnormal glycosylation (HP:0012345) | 2.24325495 |
| 76 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.24325495 |
| 77 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.24325495 |
| 78 | Cleft eyelid (HP:0000625) | 2.23669464 |
| 79 | Aplasia involving forearm bones (HP:0009822) | 2.21250248 |
| 80 | Absent forearm bone (HP:0003953) | 2.21250248 |
| 81 | Tracheoesophageal fistula (HP:0002575) | 2.18636565 |
| 82 | Multiple enchondromatosis (HP:0005701) | 2.18620601 |
| 83 | Ependymoma (HP:0002888) | 2.16986012 |
| 84 | Secondary amenorrhea (HP:0000869) | 2.16338363 |
| 85 | Reduced antithrombin III activity (HP:0001976) | 2.16031338 |
| 86 | Triphalangeal thumb (HP:0001199) | 2.15512271 |
| 87 | Lethargy (HP:0001254) | 2.14085634 |
| 88 | Abnormality of serum amino acid levels (HP:0003112) | 2.13826227 |
| 89 | IgM deficiency (HP:0002850) | 2.12443208 |
| 90 | 3-Methylglutaconic aciduria (HP:0003535) | 2.12328910 |
| 91 | Methylmalonic aciduria (HP:0012120) | 2.12028278 |
| 92 | Atresia of the external auditory canal (HP:0000413) | 2.09639124 |
| 93 | Premature ovarian failure (HP:0008209) | 2.08953566 |
| 94 | Sloping forehead (HP:0000340) | 2.08690658 |
| 95 | Irregular epiphyses (HP:0010582) | 2.04090810 |
| 96 | Hyperglycinemia (HP:0002154) | 2.00981144 |
| 97 | Lymphoma (HP:0002665) | 2.00856095 |
| 98 | Abnormality of the duodenum (HP:0002246) | 2.00489648 |
| 99 | Glossoptosis (HP:0000162) | 2.00044094 |
| 100 | Increased CSF lactate (HP:0002490) | 1.98493361 |
| 101 | Ectopic kidney (HP:0000086) | 1.98204349 |
| 102 | Muscle fiber atrophy (HP:0100295) | 1.97842153 |
| 103 | Hepatocellular necrosis (HP:0001404) | 1.97494327 |
| 104 | Rhabdomyosarcoma (HP:0002859) | 1.96368497 |
| 105 | Optic nerve coloboma (HP:0000588) | 1.94990494 |
| 106 | Pancreatic fibrosis (HP:0100732) | 1.94709313 |
| 107 | Type 2 muscle fiber atrophy (HP:0003554) | 1.93827166 |
| 108 | Supernumerary spleens (HP:0009799) | 1.93720592 |
| 109 | Pancreatic cysts (HP:0001737) | 1.93316592 |
| 110 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.91809430 |
| 111 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 1.91608705 |
| 112 | Mitochondrial inheritance (HP:0001427) | 1.91073077 |
| 113 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 1.88253261 |
| 114 | Acute necrotizing encephalopathy (HP:0006965) | 1.86451640 |
| 115 | Neoplasm of the colon (HP:0100273) | 1.86089702 |
| 116 | CNS demyelination (HP:0007305) | 1.86088541 |
| 117 | Megaloblastic anemia (HP:0001889) | 1.85519665 |
| 118 | Abnormality of the pons (HP:0007361) | 1.84630583 |
| 119 | Slender long bone (HP:0003100) | 1.83515597 |
| 120 | Sparse eyelashes (HP:0000653) | 1.83381114 |
| 121 | Facial cleft (HP:0002006) | 1.81431600 |
| 122 | Hypoplasia of the pons (HP:0012110) | 1.80674137 |
| 123 | Duplicated collecting system (HP:0000081) | 1.80317384 |
| 124 | Testicular atrophy (HP:0000029) | 1.79789789 |
| 125 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 1.79653076 |
| 126 | Abnormality of the labia minora (HP:0012880) | 1.79599098 |
| 127 | Stenosis of the external auditory canal (HP:0000402) | 1.79385039 |
| 128 | Short thumb (HP:0009778) | 1.79338570 |
| 129 | CNS hypomyelination (HP:0003429) | 1.79242204 |
| 130 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.78964941 |
| 131 | Abnormality of alanine metabolism (HP:0010916) | 1.78964941 |
| 132 | Hyperalaninemia (HP:0003348) | 1.78964941 |
| 133 | Abnormality of glycolysis (HP:0004366) | 1.78801135 |
| 134 | Increased serum pyruvate (HP:0003542) | 1.78801135 |
| 135 | Hypoplasia of the radius (HP:0002984) | 1.78421779 |
| 136 | Molar tooth sign on MRI (HP:0002419) | 1.72959202 |
| 137 | Abnormality of midbrain morphology (HP:0002418) | 1.72959202 |
| 138 | Homocystinuria (HP:0002156) | 1.72913947 |
| 139 | Abnormality of homocysteine metabolism (HP:0010919) | 1.72913947 |
| 140 | Abnormality of renal resorption (HP:0011038) | 1.70139467 |
| 141 | Pendular nystagmus (HP:0012043) | 1.68788893 |
| 142 | X-linked dominant inheritance (HP:0001423) | 1.66576561 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 4.98650274 |
| 2 | WEE1 | 4.18984066 |
| 3 | EIF2AK1 | 4.12370726 |
| 4 | VRK2 | 3.80592892 |
| 5 | CDC7 | 3.76024604 |
| 6 | PLK4 | 2.66911861 |
| 7 | SRPK1 | 2.66597265 |
| 8 | NME2 | 2.62753849 |
| 9 | STK16 | 2.56654016 |
| 10 | EIF2AK3 | 2.54870652 |
| 11 | TSSK6 | 2.38610046 |
| 12 | TRIM28 | 2.29787536 |
| 13 | BRSK2 | 2.29674551 |
| 14 | VRK1 | 2.22277207 |
| 15 | NEK2 | 2.17115184 |
| 16 | ACVR1B | 2.14587473 |
| 17 | NEK1 | 1.98962992 |
| 18 | MKNK1 | 1.92518960 |
| 19 | TTK | 1.87998417 |
| 20 | PLK1 | 1.87391759 |
| 21 | NUAK1 | 1.84690058 |
| 22 | TESK2 | 1.79078133 |
| 23 | TLK1 | 1.70273200 |
| 24 | PLK3 | 1.68158316 |
| 25 | AURKB | 1.62092251 |
| 26 | ATR | 1.60820976 |
| 27 | BRSK1 | 1.58181412 |
| 28 | MAP4K2 | 1.56715638 |
| 29 | CDK7 | 1.52592779 |
| 30 | PDK2 | 1.51367215 |
| 31 | RPS6KA4 | 1.50172825 |
| 32 | PASK | 1.44836399 |
| 33 | RPS6KB2 | 1.44165271 |
| 34 | WNK3 | 1.43027583 |
| 35 | TAF1 | 1.42224343 |
| 36 | CCNB1 | 1.40241119 |
| 37 | MKNK2 | 1.37618414 |
| 38 | DYRK3 | 1.31945239 |
| 39 | ZAK | 1.30010922 |
| 40 | BMPR1B | 1.27359315 |
| 41 | TNIK | 1.25730810 |
| 42 | PIM2 | 1.25395765 |
| 43 | PBK | 1.21879345 |
| 44 | AURKA | 1.20264624 |
| 45 | CHEK2 | 1.19595469 |
| 46 | CDK8 | 1.15138889 |
| 47 | MAP3K8 | 1.10724256 |
| 48 | TGFBR1 | 1.09067820 |
| 49 | NME1 | 1.03300255 |
| 50 | KDR | 1.02797830 |
| 51 | EPHA2 | 1.02027570 |
| 52 | CHEK1 | 1.00813319 |
| 53 | CDK4 | 0.99860373 |
| 54 | EIF2AK2 | 0.98362123 |
| 55 | TESK1 | 0.96412606 |
| 56 | STK4 | 0.91765557 |
| 57 | MAP4K1 | 0.88802913 |
| 58 | PAK4 | 0.87421378 |
| 59 | BCR | 0.86935121 |
| 60 | STK10 | 0.85603961 |
| 61 | PIM1 | 0.80592414 |
| 62 | CSNK2A1 | 0.74800487 |
| 63 | CSNK1G3 | 0.74230874 |
| 64 | CSNK1G1 | 0.72785357 |
| 65 | ATM | 0.69430034 |
| 66 | GRK1 | 0.68721404 |
| 67 | CSNK2A2 | 0.67853453 |
| 68 | IRAK3 | 0.67342091 |
| 69 | CDK2 | 0.67151310 |
| 70 | BRAF | 0.67081985 |
| 71 | SCYL2 | 0.66436306 |
| 72 | MAP3K11 | 0.64259787 |
| 73 | MAPKAPK3 | 0.63976886 |
| 74 | MAP3K12 | 0.59158135 |
| 75 | PAK1 | 0.59140273 |
| 76 | FLT3 | 0.56670744 |
| 77 | MELK | 0.56648795 |
| 78 | CSNK1E | 0.54443165 |
| 79 | CSNK1G2 | 0.53419415 |
| 80 | IRAK4 | 0.52300931 |
| 81 | PRKCI | 0.51909093 |
| 82 | CSNK1A1L | 0.51129843 |
| 83 | TAOK2 | 0.51110618 |
| 84 | DYRK2 | 0.50326986 |
| 85 | CDK1 | 0.48513512 |
| 86 | BCKDK | 0.48451742 |
| 87 | RPS6KA5 | 0.47695328 |
| 88 | TEC | 0.46665025 |
| 89 | TXK | 0.46568171 |
| 90 | STK38L | 0.45535025 |
| 91 | TAOK3 | 0.43841318 |
| 92 | BTK | 0.41644395 |
| 93 | ABL2 | 0.41016518 |
| 94 | LRRK2 | 0.40819672 |
| 95 | CDK3 | 0.40354834 |
| 96 | SIK3 | 0.39764634 |
| 97 | LIMK1 | 0.39393024 |
| 98 | OXSR1 | 0.39136615 |
| 99 | MAP2K3 | 0.39134056 |
| 100 | MINK1 | 0.38232100 |
| 101 | CDK12 | 0.37909249 |
| 102 | ILK | 0.37711875 |
| 103 | DAPK1 | 0.36606876 |
| 104 | INSRR | 0.36529269 |
| 105 | CDK19 | 0.36358119 |
| 106 | NEK9 | 0.35997569 |
| 107 | PLK2 | 0.35863294 |
| 108 | MST4 | 0.35418203 |
| 109 | KIT | 0.35229343 |
| 110 | CLK1 | 0.34645670 |
| 111 | ZAP70 | 0.33321943 |
| 112 | PRKDC | 0.32349243 |
| 113 | MAP3K10 | 0.31048096 |
| 114 | MARK3 | 0.30003089 |
| 115 | YES1 | 0.29989016 |
| 116 | BLK | 0.29661613 |
| 117 | CSNK1A1 | 0.29405734 |
| 118 | STK3 | 0.28765661 |
| 119 | WNK4 | 0.28484271 |
| 120 | ERBB3 | 0.27903378 |
| 121 | MAP2K7 | 0.27671475 |
| 122 | MAP3K4 | 0.26291038 |
| 123 | ADRBK2 | 0.26163034 |
| 124 | CDK6 | 0.25079223 |
| 125 | STK24 | 0.24896504 |
| 126 | ALK | 0.24362052 |
| 127 | LYN | 0.23959810 |
| 128 | TYK2 | 0.23934091 |
| 129 | EEF2K | 0.23885507 |
| 130 | AKT2 | 0.23799393 |
| 131 | PRKCG | 0.23689329 |
| 132 | CDK14 | 0.22575892 |
| 133 | CDK18 | 0.21748299 |
| 134 | IKBKB | 0.21582685 |
| 135 | CDK9 | 0.21345624 |
| 136 | BRD4 | 0.21039448 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA replication_Homo sapiens_hsa03030 | 4.99770269 |
| 2 | Mismatch repair_Homo sapiens_hsa03430 | 4.20153615 |
| 3 | Proteasome_Homo sapiens_hsa03050 | 4.17301067 |
| 4 | Ribosome_Homo sapiens_hsa03010 | 3.73665765 |
| 5 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.64363768 |
| 6 | RNA polymerase_Homo sapiens_hsa03020 | 3.61120323 |
| 7 | * Spliceosome_Homo sapiens_hsa03040 | 3.20213958 |
| 8 | Base excision repair_Homo sapiens_hsa03410 | 3.02791026 |
| 9 | Homologous recombination_Homo sapiens_hsa03440 | 3.02747435 |
| 10 | RNA transport_Homo sapiens_hsa03013 | 2.96851801 |
| 11 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.87263809 |
| 12 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.73975745 |
| 13 | Cell cycle_Homo sapiens_hsa04110 | 2.49060360 |
| 14 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.43150172 |
| 15 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.33973208 |
| 16 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.14255341 |
| 17 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.00843980 |
| 18 | Basal transcription factors_Homo sapiens_hsa03022 | 1.93993621 |
| 19 | RNA degradation_Homo sapiens_hsa03018 | 1.88869067 |
| 20 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.52533491 |
| 21 | Purine metabolism_Homo sapiens_hsa00230 | 1.51805586 |
| 22 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.45915710 |
| 23 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.44636331 |
| 24 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.26834923 |
| 25 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.22392541 |
| 26 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.19566751 |
| 27 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.17154703 |
| 28 | Protein export_Homo sapiens_hsa03060 | 1.16454361 |
| 29 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.09234006 |
| 30 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.08522227 |
| 31 | Parkinsons disease_Homo sapiens_hsa05012 | 1.03094118 |
| 32 | Huntingtons disease_Homo sapiens_hsa05016 | 1.01174580 |
| 33 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.96498807 |
| 34 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.96039325 |
| 35 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.93477813 |
| 36 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.93322488 |
| 37 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.90666975 |
| 38 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.87573351 |
| 39 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.86112336 |
| 40 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.84579012 |
| 41 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.83718538 |
| 42 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.83406175 |
| 43 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.83385019 |
| 44 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.78023458 |
| 45 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.76591882 |
| 46 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.75956884 |
| 47 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.73542139 |
| 48 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.72560220 |
| 49 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.72351632 |
| 50 | Legionellosis_Homo sapiens_hsa05134 | 0.71225484 |
| 51 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.68219360 |
| 52 | Sulfur relay system_Homo sapiens_hsa04122 | 0.67113845 |
| 53 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.63831312 |
| 54 | HTLV-I infection_Homo sapiens_hsa05166 | 0.62553277 |
| 55 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.62398612 |
| 56 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.61022671 |
| 57 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.57379138 |
| 58 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.54863447 |
| 59 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.54763089 |
| 60 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.49685986 |
| 61 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.48100687 |
| 62 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.46952501 |
| 63 | Carbon metabolism_Homo sapiens_hsa01200 | 0.46685836 |
| 64 | Thyroid cancer_Homo sapiens_hsa05216 | 0.45954801 |
| 65 | Phototransduction_Homo sapiens_hsa04744 | 0.45696432 |
| 66 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.43499361 |
| 67 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.43037038 |
| 68 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.42330831 |
| 69 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.42173755 |
| 70 | Measles_Homo sapiens_hsa05162 | 0.41996722 |
| 71 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.41449681 |
| 72 | Apoptosis_Homo sapiens_hsa04210 | 0.41233290 |
| 73 | Shigellosis_Homo sapiens_hsa05131 | 0.39209306 |
| 74 | Peroxisome_Homo sapiens_hsa04146 | 0.37907007 |
| 75 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.35686671 |
| 76 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.35111957 |
| 77 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.33941743 |
| 78 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.33154639 |
| 79 | Alzheimers disease_Homo sapiens_hsa05010 | 0.32252024 |
| 80 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.31926890 |
| 81 | Metabolic pathways_Homo sapiens_hsa01100 | 0.31311871 |
| 82 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.31170761 |
| 83 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.29897802 |
| 84 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.29437265 |
| 85 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.29045561 |
| 86 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.28489230 |
| 87 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.28332504 |
| 88 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.27681838 |
| 89 | Influenza A_Homo sapiens_hsa05164 | 0.27271115 |
| 90 | Hepatitis B_Homo sapiens_hsa05161 | 0.26918671 |
| 91 | Allograft rejection_Homo sapiens_hsa05330 | 0.26301824 |
| 92 | Galactose metabolism_Homo sapiens_hsa00052 | 0.26054832 |
| 93 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.25915165 |
| 94 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.25244466 |
| 95 | Asthma_Homo sapiens_hsa05310 | 0.25142496 |
| 96 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.24948849 |
| 97 | Alcoholism_Homo sapiens_hsa05034 | 0.24832994 |
| 98 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.24292121 |
| 99 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.23525036 |
| 100 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.22854571 |
| 101 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.22324128 |
| 102 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.21163195 |
| 103 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.20740525 |
| 104 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.20495849 |
| 105 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.20149441 |
| 106 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.18258019 |
| 107 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.18126072 |
| 108 | Colorectal cancer_Homo sapiens_hsa05210 | 0.17884154 |
| 109 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.17516122 |
| 110 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.16816838 |
| 111 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.16386827 |
| 112 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.16373042 |
| 113 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.15727539 |
| 114 | Viral myocarditis_Homo sapiens_hsa05416 | 0.14409117 |
| 115 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.14186159 |
| 116 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.13957220 |
| 117 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.13335460 |
| 118 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.11617452 |
| 119 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.11572657 |
| 120 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.11459218 |
| 121 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.10859571 |
| 122 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.10147599 |
| 123 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.09683768 |
| 124 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.09226275 |
| 125 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.08832615 |
| 126 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.08631844 |
| 127 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.08091538 |
| 128 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.08085378 |
| 129 | Pathways in cancer_Homo sapiens_hsa05200 | 0.07501208 |
| 130 | Retinol metabolism_Homo sapiens_hsa00830 | 0.05039126 |
| 131 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.04101564 |

