SNRPB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is one of several nuclear proteins that are found in common among U1, U2, U4/U6, and U5 small ribonucleoprotein particles (snRNPs). These snRNPs are involved in pre-mRNA splicing, and the encoded protein may also play a role in pre-mRNA splicing or snRNP structure. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding different isoforms (B and B') have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.14213889
2ribosomal small subunit assembly (GO:0000028)5.07097203
3DNA strand elongation involved in DNA replication (GO:0006271)5.03393516
4telomere maintenance via semi-conservative replication (GO:0032201)4.81261700
5DNA strand elongation (GO:0022616)4.79868367
6viral transcription (GO:0019083)4.74667741
7maturation of SSU-rRNA (GO:0030490)4.68979402
8translational termination (GO:0006415)4.64594714
9DNA replication initiation (GO:0006270)4.51268478
10DNA unwinding involved in DNA replication (GO:0006268)4.46537547
11translational elongation (GO:0006414)4.24485347
12telomere maintenance via recombination (GO:0000722)4.24259944
13formation of translation preinitiation complex (GO:0001731)4.23159331
14establishment of viral latency (GO:0019043)4.21774750
15DNA replication checkpoint (GO:0000076)4.14527791
16ribosomal large subunit biogenesis (GO:0042273)4.10164230
17translational initiation (GO:0006413)4.08591413
18protein maturation by protein folding (GO:0022417)4.06543788
19ribosomal small subunit biogenesis (GO:0042274)4.05270659
20SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.01753132
21regulation of mitochondrial translation (GO:0070129)4.01024474
22nucleobase biosynthetic process (GO:0046112)4.00501404
23DNA replication-dependent nucleosome organization (GO:0034723)3.99713822
24DNA replication-dependent nucleosome assembly (GO:0006335)3.99713822
25mitotic recombination (GO:0006312)3.96125143
26cotranslational protein targeting to membrane (GO:0006613)3.90044470
27protein targeting to ER (GO:0045047)3.89258038
28mitotic chromosome condensation (GO:0007076)3.87896987
29ribonucleoprotein complex biogenesis (GO:0022613)3.86961417
30nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.83745741
31protein localization to kinetochore (GO:0034501)3.82984893
32ribosome biogenesis (GO:0042254)3.80096417
33CENP-A containing nucleosome assembly (GO:0034080)3.76417091
34purine nucleobase biosynthetic process (GO:0009113)3.75354643
35mitotic sister chromatid segregation (GO:0000070)3.75119964
36telomere maintenance via telomere lengthening (GO:0010833)3.74988731
37chromatin remodeling at centromere (GO:0031055)3.70868817
38nucleotide-excision repair, DNA gap filling (GO:0006297)3.69859362
39establishment of protein localization to endoplasmic reticulum (GO:0072599)3.67787635
40protein localization to endoplasmic reticulum (GO:0070972)3.66560550
41viral life cycle (GO:0019058)3.64779486
42cellular protein complex disassembly (GO:0043624)3.64420310
43nucleobase-containing small molecule interconversion (GO:0015949)3.57860424
44proline biosynthetic process (GO:0006561)3.51505031
45IMP biosynthetic process (GO:0006188)3.47877614
46peptidyl-arginine omega-N-methylation (GO:0035247)3.46963231
47proteasome assembly (GO:0043248)3.45894280
48rRNA processing (GO:0006364)3.45827315
49pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.43234831
50mitotic metaphase plate congression (GO:0007080)3.42935798
51protein localization to chromosome, centromeric region (GO:0071459)3.39012930
52DNA replication-independent nucleosome assembly (GO:0006336)3.38817816
53DNA replication-independent nucleosome organization (GO:0034724)3.38817816
54deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.36878253
55pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.36396909
56regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.35685288
57regulation of translational fidelity (GO:0006450)3.35348620
58mitotic nuclear envelope disassembly (GO:0007077)3.35205829
59protein complex disassembly (GO:0043241)3.33192173
60folic acid-containing compound biosynthetic process (GO:0009396)3.33063748
61rRNA metabolic process (GO:0016072)3.32699764
62negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.32622508
63* spliceosomal snRNP assembly (GO:0000387)3.32384276
64ribosome assembly (GO:0042255)3.28511150
65translation (GO:0006412)3.28017182
66sister chromatid segregation (GO:0000819)3.27318805
67regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.22222035
68negative regulation of mRNA processing (GO:0050686)3.21800938
69anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.21585190
70viral mRNA export from host cell nucleus (GO:0046784)3.19214162
71heterochromatin organization (GO:0070828)3.17481547
72pseudouridine synthesis (GO:0001522)3.16196627
73macromolecular complex disassembly (GO:0032984)3.15961281
74histone exchange (GO:0043486)3.15616868
75nuclear-transcribed mRNA catabolic process (GO:0000956)3.13921621
76kinetochore organization (GO:0051383)3.13010035
77regulation of translational termination (GO:0006449)3.12175166
78positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.12129962
79IMP metabolic process (GO:0046040)3.10288729
80negative regulation of RNA splicing (GO:0033119)3.10228349
81base-excision repair (GO:0006284)3.08870460
82pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.08146860
83histone arginine methylation (GO:0034969)3.07847931
84mitotic nuclear envelope reassembly (GO:0007084)3.07551022
85nuclear envelope reassembly (GO:0031468)3.07551022
86transcription-coupled nucleotide-excision repair (GO:0006283)3.06330173
87negative regulation of ligase activity (GO:0051352)3.05742367
88negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.05742367
89nuclear envelope disassembly (GO:0051081)3.05458838
90membrane disassembly (GO:0030397)3.05458838
91regulation of cellular amino acid metabolic process (GO:0006521)3.03820175
92metaphase plate congression (GO:0051310)3.02439458
93deoxyribonucleotide biosynthetic process (GO:0009263)3.01270445
94signal transduction involved in cell cycle checkpoint (GO:0072395)3.00321954
95kinetochore assembly (GO:0051382)2.98527995
96positive regulation of ligase activity (GO:0051351)2.97671062
97guanosine-containing compound biosynthetic process (GO:1901070)2.97528148
98DNA ligation (GO:0006266)2.97047115
99L-serine metabolic process (GO:0006563)2.96634373
100mRNA catabolic process (GO:0006402)2.96536665
101regulation of ubiquitin-protein transferase activity (GO:0051438)2.96438829
102protein complex localization (GO:0031503)2.95365114
103G1/S transition of mitotic cell cycle (GO:0000082)2.95324580
104cell cycle G1/S phase transition (GO:0044843)2.95324580
105UTP biosynthetic process (GO:0006228)2.95111801
106establishment of integrated proviral latency (GO:0075713)2.94227733
107protein targeting to mitochondrion (GO:0006626)2.93796378
108pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.93695095
109RNA catabolic process (GO:0006401)2.92682324
110cellular component biogenesis (GO:0044085)2.91593109
111spliceosomal complex assembly (GO:0000245)2.91185777
112telomere organization (GO:0032200)2.90896627
113telomere maintenance (GO:0000723)2.89791126
114pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.88566553
115regulation of ligase activity (GO:0051340)2.85618139
116DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.84620793
117regulation of double-strand break repair via homologous recombination (GO:0010569)2.82579517
118signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.81573741
119intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.81573741
120signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.80850076
121signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.80850076
122signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.80850076
123exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.79073330
124termination of RNA polymerase III transcription (GO:0006386)2.79000593
125transcription elongation from RNA polymerase III promoter (GO:0006385)2.79000593
126attachment of spindle microtubules to kinetochore (GO:0008608)2.78095166
127positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.76756609
128signal transduction involved in DNA damage checkpoint (GO:0072422)2.76374215
129signal transduction involved in DNA integrity checkpoint (GO:0072401)2.76374215
130rRNA modification (GO:0000154)2.75719862
131regulation of spindle organization (GO:0090224)2.74840061
132establishment of chromosome localization (GO:0051303)2.73906293
133regulation of nuclear cell cycle DNA replication (GO:0033262)2.73444010
134negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.73119516

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.82736298
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.39117116
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.92391429
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.37946021
5* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.35176285
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.03790190
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.97876435
8* EST1_17652178_ChIP-ChIP_JURKAT_Human2.94440016
9MYC_18358816_ChIP-ChIP_MESCs_Mouse2.93481382
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.93466197
11* GABP_17652178_ChIP-ChIP_JURKAT_Human2.86349853
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.84703484
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.80769515
14* ETS1_20019798_ChIP-Seq_JURKAT_Human2.78315370
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.58234426
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.56577994
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.51727919
18* XRN2_22483619_ChIP-Seq_HELA_Human2.46333027
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.30656448
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.30525623
21* VDR_23849224_ChIP-Seq_CD4+_Human2.22580343
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.19572027
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.14244617
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.05665987
25* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.02083305
26* FOXP3_21729870_ChIP-Seq_TREG_Human1.96658775
27SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.95377611
28DCP1A_22483619_ChIP-Seq_HELA_Human1.93691931
29TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.87617294
30MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.87197673
31* TTF2_22483619_ChIP-Seq_HELA_Human1.86628434
32* GABP_19822575_ChIP-Seq_HepG2_Human1.83715021
33AR_21909140_ChIP-Seq_LNCAP_Human1.82139269
34* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.77088861
35* E2F1_21310950_ChIP-Seq_MCF-7_Human1.73633062
36EGR1_19374776_ChIP-ChIP_THP-1_Human1.71861722
37THAP11_20581084_ChIP-Seq_MESCs_Mouse1.70869199
38MYCN_18555785_ChIP-Seq_MESCs_Mouse1.70843995
39CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.65280656
40MYC_22102868_ChIP-Seq_BL_Human1.61489419
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60296372
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.58181000
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.57181635
44* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.56468017
45CIITA_25753668_ChIP-Seq_RAJI_Human1.56356608
46FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.55575371
47E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.55153673
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.52942317
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.51870981
50* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.51625679
51ZNF263_19887448_ChIP-Seq_K562_Human1.50033021
52* ELK1_19687146_ChIP-ChIP_HELA_Human1.48792087
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.47171258
54PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.46386456
55SRF_21415370_ChIP-Seq_HL-1_Mouse1.46142576
56ERG_20887958_ChIP-Seq_HPC-7_Mouse1.43073704
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.41544024
58CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.41312362
59NOTCH1_21737748_ChIP-Seq_TLL_Human1.32945711
60ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.30063107
61KDM5A_27292631_Chip-Seq_BREAST_Human1.30030182
62SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.29439403
63YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27658251
64VDR_21846776_ChIP-Seq_THP-1_Human1.22098980
65STAT3_1855785_ChIP-Seq_MESCs_Mouse1.20304434
66POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.18669159
67MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18254063
68CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.14424472
69TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13307952
70SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.12807464
71KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.12735352
72CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.12557196
73ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.12078733
74KLF4_18555785_ChIP-Seq_MESCs_Mouse1.09841354
75E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08658931
76* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08619241
77DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08161813
78* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.07758631
79POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.07106301
80TFEB_21752829_ChIP-Seq_HELA_Human1.06514938
81NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.04546318
82TET1_21451524_ChIP-Seq_MESCs_Mouse1.03921047
83PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.03861019
84SPI1_23547873_ChIP-Seq_NB4_Human1.02501606
85TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.01677347
86KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.00406836
87GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99973193
88HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98362951
89SRY_22984422_ChIP-ChIP_TESTIS_Rat0.97711311
90ESR1_15608294_ChIP-ChIP_MCF-7_Human0.97377992
91CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.96329544
92SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.95479338
93ELK3_25401928_ChIP-Seq_HUVEC_Human0.95083998
94BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.94346217
95* MYC_18940864_ChIP-ChIP_HL60_Human0.94202342
96IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.94135329
97PADI4_21655091_ChIP-ChIP_MCF-7_Human0.93859489
98CTCF_18555785_ChIP-Seq_MESCs_Mouse0.93407320
99* FOXP1_21924763_ChIP-Seq_HESCs_Human0.91265316
100ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91188738
101* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.90773234
102SOX2_18555785_ChIP-Seq_MESCs_Mouse0.90576335
103TP63_19390658_ChIP-ChIP_HaCaT_Human0.88062709
104TBX5_21415370_ChIP-Seq_HL-1_Mouse0.86762718
105* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86428957
106ELK1_22589737_ChIP-Seq_MCF10A_Human0.82804436
107CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.81214776
108OCT4_18692474_ChIP-Seq_MEFs_Mouse0.77173110
109STAT4_19710469_ChIP-ChIP_TH1__Mouse0.77035785
110CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.76622052
111RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.75483343
112SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.73947207
113GATA1_22383799_ChIP-Seq_G1ME_Mouse0.73525560
114DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.72651447

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.99833167
2MP0010094_abnormal_chromosome_stability4.24358240
3MP0004957_abnormal_blastocyst_morpholog4.02213096
4MP0003111_abnormal_nucleus_morphology3.99574266
5MP0003077_abnormal_cell_cycle3.66958101
6MP0008057_abnormal_DNA_replication3.39147491
7MP0008058_abnormal_DNA_repair3.21255219
8MP0008007_abnormal_cellular_replicative2.79537304
9MP0002396_abnormal_hematopoietic_system2.57474327
10MP0008932_abnormal_embryonic_tissue2.53462832
11MP0002877_abnormal_melanocyte_morpholog2.14008568
12MP0001730_embryonic_growth_arrest2.07458800
13MP0000490_abnormal_crypts_of2.03257993
14MP0003786_premature_aging1.94548906
15MP0000350_abnormal_cell_proliferation1.94167970
16MP0010352_gastrointestinal_tract_polyps1.91429056
17MP0005451_abnormal_body_composition1.90555897
18MP0008877_abnormal_DNA_methylation1.78721500
19MP0003763_abnormal_thymus_physiology1.74850490
20MP0003123_paternal_imprinting1.74671039
21MP0004808_abnormal_hematopoietic_stem1.65957521
22MP0006054_spinal_hemorrhage1.64338410
23MP0006035_abnormal_mitochondrial_morpho1.60445532
24MP0009333_abnormal_splenocyte_physiolog1.59812767
25MP0009379_abnormal_foot_pigmentation1.55442787
26MP0002019_abnormal_tumor_incidence1.53736251
27MP0000313_abnormal_cell_death1.52302018
28MP0005397_hematopoietic_system_phenotyp1.50049378
29MP0001545_abnormal_hematopoietic_system1.50049378
30MP0005501_abnormal_skin_physiology1.49585627
31MP0001697_abnormal_embryo_size1.48627131
32MP0010307_abnormal_tumor_latency1.48228999
33MP0000537_abnormal_urethra_morphology1.47247036
34MP0009697_abnormal_copulation1.46483647
35MP0003806_abnormal_nucleotide_metabolis1.44467983
36MP0005380_embryogenesis_phenotype1.42567917
37MP0001672_abnormal_embryogenesis/_devel1.42567917
38MP0002080_prenatal_lethality1.42409895
39MP0008260_abnormal_autophagy1.41237275
40MP0002163_abnormal_gland_morphology1.41166172
41MP0002398_abnormal_bone_marrow1.34636537
42MP0003186_abnormal_redox_activity1.33448011
43MP0004185_abnormal_adipocyte_glucose1.31458146
44MP0003984_embryonic_growth_retardation1.31453703
45MP0002132_abnormal_respiratory_system1.30923532
46MP0000703_abnormal_thymus_morphology1.30029315
47MP0001853_heart_inflammation1.28729261
48MP0002722_abnormal_immune_system1.28256241
49MP0002088_abnormal_embryonic_growth/wei1.27396838
50MP0010030_abnormal_orbit_morphology1.26640772
51MP0000689_abnormal_spleen_morphology1.22801186
52MP0002085_abnormal_embryonic_tissue1.22764505
53MP0005058_abnormal_lysosome_morphology1.21021356
54MP0002210_abnormal_sex_determination1.20796919
55MP0001346_abnormal_lacrimal_gland1.20026898
56MP0001835_abnormal_antigen_presentation1.17229279
57MP0003567_abnormal_fetal_cardiomyocyte1.14740228
58MP0002429_abnormal_blood_cell1.10194721
59MP0001145_abnormal_male_reproductive1.08199958
60MP0002086_abnormal_extraembryonic_tissu1.07406823
61MP0000858_altered_metastatic_potential1.07296200
62MP0002796_impaired_skin_barrier1.07179510
63MP0000678_abnormal_parathyroid_gland1.07012360
64MP0001727_abnormal_embryo_implantation1.06715780
65MP0001293_anophthalmia1.04477070
66MP0000685_abnormal_immune_system1.03896768
67MP0004197_abnormal_fetal_growth/weight/1.03142956
68MP0001661_extended_life_span1.02642457
69MP0004233_abnormal_muscle_weight1.02603501
70MP0002084_abnormal_developmental_patter1.02044754
71MP0001929_abnormal_gametogenesis1.02006092
72MP0000716_abnormal_immune_system0.99226648
73MP0003718_maternal_effect0.98823456
74MP0002653_abnormal_ependyma_morphology0.97777042
75MP0003315_abnormal_perineum_morphology0.97699033
76MP0001881_abnormal_mammary_gland0.95335722
77MP0005384_cellular_phenotype0.95168192
78MP0001849_ear_inflammation0.94000083
79MP0009785_altered_susceptibility_to0.93345775
80MP0000358_abnormal_cell_content/0.93190639
81MP0003436_decreased_susceptibility_to0.90250877
82MP0005671_abnormal_response_to0.89624207
83MP0002160_abnormal_reproductive_system0.88937384
84MP0000653_abnormal_sex_gland0.88092931
85MP0002405_respiratory_system_inflammati0.87505782
86MP0005075_abnormal_melanosome_morpholog0.87066759
87MP0003890_abnormal_embryonic-extraembry0.86987783
88MP0002420_abnormal_adaptive_immunity0.86685238
89MP0001800_abnormal_humoral_immune0.86595381
90MP0001819_abnormal_immune_cell0.85469458
91MP0004133_heterotaxia0.84244755
92MP0005621_abnormal_cell_physiology0.84120642
93MP0002452_abnormal_antigen_presenting0.84033734
94MP0006036_abnormal_mitochondrial_physio0.81836169
95MP0005174_abnormal_tail_pigmentation0.81454312
96MP0003705_abnormal_hypodermis_morpholog0.80974588
97MP0010234_abnormal_vibrissa_follicle0.80594642
98MP0003566_abnormal_cell_adhesion0.79855016
99MP0005023_abnormal_wound_healing0.79275908
100MP0002095_abnormal_skin_pigmentation0.77418226
101MP0002723_abnormal_immune_serum0.76991625
102MP0005025_abnormal_response_to0.76567727
103MP0001119_abnormal_female_reproductive0.75438420
104MP0009278_abnormal_bone_marrow0.74007685
105MP0005330_cardiomyopathy0.73201469
106MP0009053_abnormal_anal_canal0.73066893
107MP0000477_abnormal_intestine_morphology0.72430888
108MP0003119_abnormal_digestive_system0.72214743
109MP0002006_tumorigenesis0.72161006
110MP0003941_abnormal_skin_development0.70577808
111MP0002697_abnormal_eye_size0.70220578
112MP0005389_reproductive_system_phenotype0.68370716
113MP0001216_abnormal_epidermal_layer0.67811394
114MP0010155_abnormal_intestine_physiology0.67724361
115MP0005076_abnormal_cell_differentiation0.67334121
116MP0006292_abnormal_olfactory_placode0.67186759
117MP0005623_abnormal_meninges_morphology0.66485823
118MP0005000_abnormal_immune_tolerance0.66037948
119MP0002102_abnormal_ear_morphology0.65922650
120MP0001764_abnormal_homeostasis0.65782956
121MP0002166_altered_tumor_susceptibility0.65518492
122MP0003221_abnormal_cardiomyocyte_apopto0.64964076
123MP0002111_abnormal_tail_morphology0.64483037
124MP0002060_abnormal_skin_morphology0.63804979
125MP0000750_abnormal_muscle_regeneration0.63677568
126MP0002148_abnormal_hypersensitivity_rea0.63544460
127MP0000465_gastrointestinal_hemorrhage0.62887761
128MP0009672_abnormal_birth_weight0.62200202
129MP0001915_intracranial_hemorrhage0.62104088
130MP0000627_abnormal_mammary_gland0.61348930
131MP0003453_abnormal_keratinocyte_physiol0.59517105
132MP0005408_hypopigmentation0.58986049
133MP0005379_endocrine/exocrine_gland_phen0.57849254
134MP0000372_irregular_coat_pigmentation0.57593186
135MP0002092_abnormal_eye_morphology0.57311819
136MP0003699_abnormal_female_reproductive0.55485096
137MP0002254_reproductive_system_inflammat0.55380101
138MP0004858_abnormal_nervous_system0.53838952
139MP0002938_white_spotting0.53813073

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.97487784
2Abnormality of cells of the erythroid lineage (HP:0012130)4.92700733
3Abnormal number of erythroid precursors (HP:0012131)4.85980754
4Birth length less than 3rd percentile (HP:0003561)4.58882259
5Microvesicular hepatic steatosis (HP:0001414)4.42312899
6Oral leukoplakia (HP:0002745)3.67347119
7Colon cancer (HP:0003003)3.51581407
8Aplastic anemia (HP:0001915)3.48369945
9Pallor (HP:0000980)3.43854996
10Breast hypoplasia (HP:0003187)3.41769338
11Macrocytic anemia (HP:0001972)3.39171840
12Degeneration of anterior horn cells (HP:0002398)3.38742668
13Abnormality of the anterior horn cell (HP:0006802)3.38742668
14Abnormality of glycolysis (HP:0004366)3.38030342
15Selective tooth agenesis (HP:0001592)3.31869194
16Tongue fasciculations (HP:0001308)3.10818207
17Increased serum pyruvate (HP:0003542)3.08896658
18Microretrognathia (HP:0000308)3.07448776
19Abnormal mitochondria in muscle tissue (HP:0008316)3.02169235
20Ragged-red muscle fibers (HP:0003200)3.00418671
21Patellar aplasia (HP:0006443)2.87893790
22Rough bone trabeculation (HP:0100670)2.87290549
23Trismus (HP:0000211)2.86692441
24Hepatocellular necrosis (HP:0001404)2.80498746
25Muscle fibrillation (HP:0010546)2.79562138
26Carpal bone hypoplasia (HP:0001498)2.78503651
27Thrombocytosis (HP:0001894)2.76746431
2811 pairs of ribs (HP:0000878)2.76368922
29Aplasia/Hypoplasia of the patella (HP:0006498)2.75973203
30Acute necrotizing encephalopathy (HP:0006965)2.75183066
31Absent thumb (HP:0009777)2.71582167
32Decreased activity of mitochondrial respiratory chain (HP:0008972)2.71533374
33Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.71533374
34Chromsome breakage (HP:0040012)2.68439991
35Aplasia/Hypoplasia of the sacrum (HP:0008517)2.64383448
36Abnormal gallbladder physiology (HP:0012438)2.61325843
37Cholecystitis (HP:0001082)2.61325843
38Chromosomal breakage induced by crosslinking agents (HP:0003221)2.60250765
39Meckel diverticulum (HP:0002245)2.59002461
40Acute encephalopathy (HP:0006846)2.57468074
41Mitochondrial inheritance (HP:0001427)2.57250274
42Testicular atrophy (HP:0000029)2.56930772
43Hepatic necrosis (HP:0002605)2.53413374
44Abnormality of the preputium (HP:0100587)2.52380068
45Increased CSF lactate (HP:0002490)2.52136311
46Abnormality of the umbilical cord (HP:0010881)2.49384088
47Abnormality of the ileum (HP:0001549)2.47715231
48Neoplasm of the pancreas (HP:0002894)2.46255893
49Broad distal phalanx of finger (HP:0009836)2.44092774
50Premature graying of hair (HP:0002216)2.43357305
51Medulloblastoma (HP:0002885)2.41793463
52Increased intramyocellular lipid droplets (HP:0012240)2.41375052
53Chronic otitis media (HP:0000389)2.38583572
54Agnosia (HP:0010524)2.37026222
55Multiple enchondromatosis (HP:0005701)2.36123042
56Proximal placement of thumb (HP:0009623)2.33376807
57Abnormality of chromosome stability (HP:0003220)2.30369293
58Myelodysplasia (HP:0002863)2.30079015
59Exercise intolerance (HP:0003546)2.28616178
60Cerebral hypomyelination (HP:0006808)2.28521526
61Cleft eyelid (HP:0000625)2.25213156
62Deviation of the thumb (HP:0009603)2.23655840
63Pancytopenia (HP:0001876)2.23586815
64Reduced antithrombin III activity (HP:0001976)2.23431733
65Bone marrow hypocellularity (HP:0005528)2.23341710
66IgM deficiency (HP:0002850)2.23134729
67Lactic acidosis (HP:0003128)2.22539794
68Poor head control (HP:0002421)2.20945721
69Aplasia/Hypoplasia of the uvula (HP:0010293)2.19036755
70Increased hepatocellular lipid droplets (HP:0006565)2.18325062
71Type I transferrin isoform profile (HP:0003642)2.17949935
72Duodenal stenosis (HP:0100867)2.17859166
73Small intestinal stenosis (HP:0012848)2.17859166
74Cellular immunodeficiency (HP:0005374)2.17625028
75Abnormality of the fetal cardiovascular system (HP:0010948)2.15509751
76Abnormal umbilical cord blood vessels (HP:0011403)2.15509751
77Single umbilical artery (HP:0001195)2.15509751
78Triphalangeal thumb (HP:0001199)2.15255690
79Increased muscle lipid content (HP:0009058)2.14735848
80Cerebral edema (HP:0002181)2.13147417
81Muscle fiber atrophy (HP:0100295)2.13080160
82Abnormal lung lobation (HP:0002101)2.12727507
83Tracheoesophageal fistula (HP:0002575)2.12115733
84Abnormal number of incisors (HP:0011064)2.08758094
85Progressive external ophthalmoplegia (HP:0000590)2.08060390
86Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.06348925
87Lymphoma (HP:0002665)2.06186777
88Abnormal protein glycosylation (HP:0012346)2.05667916
89Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.05667916
90Abnormal protein N-linked glycosylation (HP:0012347)2.05667916
91Hyperacusis (HP:0010780)2.04502230
92Absent radius (HP:0003974)2.03540134
93Entropion (HP:0000621)2.02557983
94Impulsivity (HP:0100710)2.02048933
95Abnormality of reticulocytes (HP:0004312)2.01984842
96Increased serum lactate (HP:0002151)2.00915128
97Type 2 muscle fiber atrophy (HP:0003554)1.99623284
98Lipid accumulation in hepatocytes (HP:0006561)1.99454349
99Basal cell carcinoma (HP:0002671)1.98849062
100Spastic diplegia (HP:0001264)1.98135913
101Abnormality of the heme biosynthetic pathway (HP:0010472)1.98134427
102Abnormal spermatogenesis (HP:0008669)1.98080983
103Sloping forehead (HP:0000340)1.97499055
104Respiratory difficulties (HP:0002880)1.96733118
105Slender long bone (HP:0003100)1.96715704
106Abnormalities of placenta or umbilical cord (HP:0001194)1.96675215
107Sparse eyelashes (HP:0000653)1.95197396
108Horseshoe kidney (HP:0000085)1.94054304
109Duplicated collecting system (HP:0000081)1.92171042
110Ependymoma (HP:0002888)1.91305740
111Atresia of the external auditory canal (HP:0000413)1.90689847
112Abnormal trabecular bone morphology (HP:0100671)1.90479632
113Abnormality of pyrimidine metabolism (HP:0004353)1.90075209
114Poikiloderma (HP:0001029)1.88303998
115Recurrent bronchitis (HP:0002837)1.87541125
116Increased nuchal translucency (HP:0010880)1.85089383
117Facial cleft (HP:0002006)1.84757956
118Absent forearm bone (HP:0003953)1.84524869
119Aplasia involving forearm bones (HP:0009822)1.84524869
120Supernumerary spleens (HP:0009799)1.84248107
121Elevated erythrocyte sedimentation rate (HP:0003565)1.83808677
122Atrophy/Degeneration involving motor neurons (HP:0007373)1.82787444
123Abnormality of the duodenum (HP:0002246)1.82043516
124Petechiae (HP:0000967)1.81936590
125Hypoplasia of the capital femoral epiphysis (HP:0003090)1.81070969
126Premature ovarian failure (HP:0008209)1.80723545
127Progressive macrocephaly (HP:0004481)1.80364880
128Nasal polyposis (HP:0100582)1.80026977
129Gout (HP:0001997)1.79850838
130Neoplasm of the colon (HP:0100273)1.79845017
131Fasciculations (HP:0002380)1.79037167
132Progressive muscle weakness (HP:0003323)1.77143180
133Orthostatic hypotension (HP:0001278)1.76878588
134Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.76558687
135Vertebral compression fractures (HP:0002953)1.76502983
136Hypergonadotropic hypogonadism (HP:0000815)1.75444440
137Optic nerve coloboma (HP:0000588)1.75393968
138Absent epiphyses (HP:0010577)1.73629009
139Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.73629009
140Rhabdomyosarcoma (HP:0002859)1.72204784
141Glossoptosis (HP:0000162)1.71122775
142Abnormality of the renal collecting system (HP:0004742)1.70524560
143Respiratory failure (HP:0002878)1.70316410
144Secondary amenorrhea (HP:0000869)1.69677110
145Achilles tendon contracture (HP:0001771)1.69432305
146Septate vagina (HP:0001153)1.67877550
147Hypoplasia of the radius (HP:0002984)1.66871848
148High pitched voice (HP:0001620)1.66869284
149Abnormality of the distal phalanges of the toes (HP:0010182)1.65930446
150Insomnia (HP:0100785)1.65888727
151Squamous cell carcinoma (HP:0002860)1.65065728
152Abnormality of the carotid arteries (HP:0005344)1.64795493
153Death in infancy (HP:0001522)1.64602550
154High anterior hairline (HP:0009890)1.64146903
155Hepatosplenomegaly (HP:0001433)1.63699565
156Amaurosis fugax (HP:0100576)1.63680341
157Abnormal glycosylation (HP:0012345)1.63358765

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.71302940
2VRK24.39952019
3WEE14.24300450
4CDC73.31865736
5SMG13.06696375
6EIF2AK12.98321584
7NME22.85742745
8TLK12.61264547
9STK162.45425600
10NEK22.34801638
11TESK22.31879415
12ACVR1B2.15484665
13VRK12.07970880
14BRSK22.07436542
15SRPK12.03389311
16PLK41.97229483
17EIF2AK31.91348029
18TSSK61.90455115
19RPS6KA41.76461792
20TTK1.72914312
21NEK11.71082182
22PLK11.69286093
23PASK1.64209339
24CDK71.62918654
25DYRK31.60235548
26MKNK11.59043369
27KDR1.58273210
28AURKB1.49524036
29PIM21.48575630
30ARAF1.48254273
31RPS6KB21.46569022
32ATR1.44020901
33MAP4K11.41330317
34ZAK1.41048552
35SCYL21.38000593
36BRSK11.28462592
37TRIB31.27905373
38AURKA1.27536063
39MAP3K101.24225575
40MAP3K81.22603956
41MAP3K111.19831080
42STK101.19696818
43TGFBR11.17596839
44PAK41.16712776
45EEF2K1.16043884
46STK41.15739778
47CHEK21.15701340
48TAF11.14946986
49CDK41.14419145
50MKNK21.13868267
51CCNB11.10415375
52TESK11.09829053
53ICK1.01710510
54FLT31.00490678
55DAPK10.98190195
56PIM10.95934943
57PBK0.94748707
58PLK30.93734613
59BCKDK0.93058167
60MAP2K30.91967073
61CHEK10.90288725
62EPHA20.87873706
63LRRK20.86830686
64ZAP700.86689749
65MST1R0.83812734
66MAPKAPK30.81173084
67PKN20.80439465
68EIF2AK20.80031839
69BTK0.74233474
70ABL20.74006734
71PDK20.72214003
72PAK10.70049316
73BLK0.68242001
74CSNK1G30.67994608
75PRPF4B0.65572117
76CSNK2A10.64880728
77CLK10.64512469
78CSNK2A20.64216778
79CDK120.63965734
80RPS6KA50.62651231
81TEC0.61079266
82PDK30.56251412
83PDK40.56251412
84CDK20.55770613
85DAPK30.55200476
86TYK20.53976188
87KIT0.53128077
88ATM0.52844299
89LMTK20.52725270
90JAK30.51372722
91ALK0.50768661
92TAOK20.49948412
93MAPK110.49338308
94CDK190.48262358
95CDK11A0.48245425
96CDK90.47858469
97CSNK1A1L0.47237833
98IRAK40.44558439
99NME10.44503289
100IKBKB0.44382447
101ILK0.43909020
102CDK140.43510883
103CDK150.42932816
104CDK80.42205811
105BMX0.40584896
106MAP3K30.40499298
107CDK180.40377893
108PRKCI0.40132072
109ERBB40.39707784
110YES10.38511436
111CSNK1G10.38345239
112RAF10.38232637
113MELK0.37680786
114BRAF0.37362965
115NLK0.36934199
116GRK60.36249286
117CDK60.36097136
118TBK10.35653247
119CDK10.33991984
120CSF1R0.33564055
121AKT20.31908499
122LYN0.30543748
123MAPKAPK20.30422062
124IRAK30.29931126
125ERN10.28749055
126LIMK10.26575615
127MST40.25099098
128MTOR0.22761429

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.12112723
2Ribosome_Homo sapiens_hsa030104.16688533
3Mismatch repair_Homo sapiens_hsa034304.12207499
4Proteasome_Homo sapiens_hsa030503.58039212
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.41968958
6* Spliceosome_Homo sapiens_hsa030403.12181618
7Base excision repair_Homo sapiens_hsa034103.10867696
8RNA polymerase_Homo sapiens_hsa030203.05557733
9Homologous recombination_Homo sapiens_hsa034402.99701874
10RNA transport_Homo sapiens_hsa030132.74154990
11Nucleotide excision repair_Homo sapiens_hsa034202.65160173
12Pyrimidine metabolism_Homo sapiens_hsa002402.56803907
13One carbon pool by folate_Homo sapiens_hsa006702.38386577
14Cell cycle_Homo sapiens_hsa041102.34524194
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.14911563
16Fanconi anemia pathway_Homo sapiens_hsa034601.98014933
17Basal transcription factors_Homo sapiens_hsa030221.70798712
18Non-homologous end-joining_Homo sapiens_hsa034501.66742914
19RNA degradation_Homo sapiens_hsa030181.63674809
20p53 signaling pathway_Homo sapiens_hsa041151.53224481
21* Systemic lupus erythematosus_Homo sapiens_hsa053221.46950538
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.42861221
23Purine metabolism_Homo sapiens_hsa002301.34849834
24mRNA surveillance pathway_Homo sapiens_hsa030151.28481897
25Fatty acid elongation_Homo sapiens_hsa000621.28141321
26Pentose phosphate pathway_Homo sapiens_hsa000301.27789392
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.24528764
28Epstein-Barr virus infection_Homo sapiens_hsa051691.17905817
29Pyruvate metabolism_Homo sapiens_hsa006201.07010496
30Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.04661407
31Herpes simplex infection_Homo sapiens_hsa051681.02400078
32Antigen processing and presentation_Homo sapiens_hsa046121.02260244
33Folate biosynthesis_Homo sapiens_hsa007900.99290150
34Protein export_Homo sapiens_hsa030600.98402121
35Viral carcinogenesis_Homo sapiens_hsa052030.92914056
36Selenocompound metabolism_Homo sapiens_hsa004500.91912247
37Biosynthesis of amino acids_Homo sapiens_hsa012300.90970859
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87806064
39Cysteine and methionine metabolism_Homo sapiens_hsa002700.87478582
40Drug metabolism - other enzymes_Homo sapiens_hsa009830.86062700
41Alzheimers disease_Homo sapiens_hsa050100.85281160
42Huntingtons disease_Homo sapiens_hsa050160.82375629
43Sulfur relay system_Homo sapiens_hsa041220.81820875
44Primary immunodeficiency_Homo sapiens_hsa053400.79669561
45Legionellosis_Homo sapiens_hsa051340.77248193
46Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74610727
47HTLV-I infection_Homo sapiens_hsa051660.70761875
48Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.69893570
49N-Glycan biosynthesis_Homo sapiens_hsa005100.66659169
50Glutathione metabolism_Homo sapiens_hsa004800.65336696
51Parkinsons disease_Homo sapiens_hsa050120.64814848
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64230847
53Carbon metabolism_Homo sapiens_hsa012000.63251909
54Cyanoamino acid metabolism_Homo sapiens_hsa004600.62623782
55Oocyte meiosis_Homo sapiens_hsa041140.59879593
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59741544
57Thyroid cancer_Homo sapiens_hsa052160.58869124
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53768733
59Measles_Homo sapiens_hsa051620.53177922
60Apoptosis_Homo sapiens_hsa042100.51944878
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51226907
62Small cell lung cancer_Homo sapiens_hsa052220.49277109
63Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48522992
64Shigellosis_Homo sapiens_hsa051310.47184999
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.46484403
66Alcoholism_Homo sapiens_hsa050340.45703047
67NF-kappa B signaling pathway_Homo sapiens_hsa040640.42872956
68Steroid biosynthesis_Homo sapiens_hsa001000.42745846
69Arginine and proline metabolism_Homo sapiens_hsa003300.42258841
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42135536
71Vibrio cholerae infection_Homo sapiens_hsa051100.41352281
72Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.40980338
73Oxidative phosphorylation_Homo sapiens_hsa001900.40973134
74Sulfur metabolism_Homo sapiens_hsa009200.40716250
75Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38154412
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37818356
77Phenylalanine metabolism_Homo sapiens_hsa003600.37297966
78Galactose metabolism_Homo sapiens_hsa000520.37286570
79Other glycan degradation_Homo sapiens_hsa005110.37164109
80Renin-angiotensin system_Homo sapiens_hsa046140.36126822
81Fructose and mannose metabolism_Homo sapiens_hsa000510.34827070
82Hematopoietic cell lineage_Homo sapiens_hsa046400.33830450
832-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.33656140
84Intestinal immune network for IgA production_Homo sapiens_hsa046720.33356333
85Hepatitis B_Homo sapiens_hsa051610.33216437
86Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.33064232
87Influenza A_Homo sapiens_hsa051640.31868631
88MicroRNAs in cancer_Homo sapiens_hsa052060.30057557
89Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.29745497
90RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.29677294
91Metabolic pathways_Homo sapiens_hsa011000.27961080
92Fatty acid metabolism_Homo sapiens_hsa012120.27268816
93Leishmaniasis_Homo sapiens_hsa051400.27019129
94Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.26595297
95Bladder cancer_Homo sapiens_hsa052190.24953519
96Asthma_Homo sapiens_hsa053100.24808657
97Vitamin B6 metabolism_Homo sapiens_hsa007500.24193166
98Pancreatic cancer_Homo sapiens_hsa052120.22532276
99Viral myocarditis_Homo sapiens_hsa054160.22247075
100Notch signaling pathway_Homo sapiens_hsa043300.22137085
101Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.21417389
102Allograft rejection_Homo sapiens_hsa053300.21386385
103Acute myeloid leukemia_Homo sapiens_hsa052210.21031833
104Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.19537776
105HIF-1 signaling pathway_Homo sapiens_hsa040660.19387509
106NOD-like receptor signaling pathway_Homo sapiens_hsa046210.19385419
107Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.19283270
108Lysine degradation_Homo sapiens_hsa003100.19082341
109Basal cell carcinoma_Homo sapiens_hsa052170.19062163
110Jak-STAT signaling pathway_Homo sapiens_hsa046300.18106371
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.18070350
112Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.18054364
113Tyrosine metabolism_Homo sapiens_hsa003500.17584912
114Chronic myeloid leukemia_Homo sapiens_hsa052200.16787278
115Colorectal cancer_Homo sapiens_hsa052100.16182869
116Central carbon metabolism in cancer_Homo sapiens_hsa052300.15447263
117TGF-beta signaling pathway_Homo sapiens_hsa043500.15202722
118Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.14821234
119Non-small cell lung cancer_Homo sapiens_hsa052230.14227621
120Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.13091487
121Arginine biosynthesis_Homo sapiens_hsa002200.12141172

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