SNRPC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of the specific protein components of the U1 small nuclear ribonucleoprotein (snRNP) particle required for the formation of the spliceosome. The encoded protein participates in the processing of nuclear precursor messenger RNA splicing. snRNP particles are attacked by autoantibodies frequently produced by patients with connective tissue diseases. The genome contains several pseudogenes of this functional gene. Alternative splicing results in a non-coding transcript variant. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.48427220
2energy coupled proton transport, down electrochemical gradient (GO:0015985)5.65327341
3ATP synthesis coupled proton transport (GO:0015986)5.65327341
4establishment of protein localization to mitochondrial membrane (GO:0090151)5.17705025
5chaperone-mediated protein transport (GO:0072321)5.09434210
6DNA deamination (GO:0045006)5.08392349
7mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.80632397
8respiratory electron transport chain (GO:0022904)4.68875752
9electron transport chain (GO:0022900)4.57130986
10establishment of integrated proviral latency (GO:0075713)4.50574410
11cotranslational protein targeting to membrane (GO:0006613)4.41772643
12protein targeting to ER (GO:0045047)4.35781704
13formation of translation preinitiation complex (GO:0001731)4.31860790
14regulation of mitochondrial translation (GO:0070129)4.29257173
15mitotic metaphase plate congression (GO:0007080)4.24435723
16DNA strand elongation involved in DNA replication (GO:0006271)4.23321058
17establishment of protein localization to endoplasmic reticulum (GO:0072599)4.17573584
18protein localization to endoplasmic reticulum (GO:0070972)4.11866083
19telomere maintenance via semi-conservative replication (GO:0032201)4.08958967
20ribosome biogenesis (GO:0042254)4.06892604
21DNA strand elongation (GO:0022616)4.04258020
22DNA replication initiation (GO:0006270)4.03189138
23DNA replication checkpoint (GO:0000076)4.01256461
24protein complex biogenesis (GO:0070271)4.00609729
25maturation of SSU-rRNA (GO:0030490)3.98816150
26mitochondrial respiratory chain complex assembly (GO:0033108)3.92976735
27regulation of cellular amino acid metabolic process (GO:0006521)3.88036672
28mitochondrial respiratory chain complex I assembly (GO:0032981)3.82489623
29NADH dehydrogenase complex assembly (GO:0010257)3.82489623
30mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.82489623
31protein localization to kinetochore (GO:0034501)3.81307295
32ribonucleoprotein complex biogenesis (GO:0022613)3.81263126
33nucleobase biosynthetic process (GO:0046112)3.80232352
34DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.78755743
35ribosomal large subunit biogenesis (GO:0042273)3.77861060
36purine nucleobase biosynthetic process (GO:0009113)3.76954285
37ribosomal small subunit assembly (GO:0000028)3.76158662
38protein targeting to mitochondrion (GO:0006626)3.75386604
39signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.74156337
40signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.74156337
41signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.74156337
42signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.72505992
43intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.72505992
44viral life cycle (GO:0019058)3.71215889
45establishment of viral latency (GO:0019043)3.69921725
46cellular protein complex disassembly (GO:0043624)3.69407643
47telomere maintenance via recombination (GO:0000722)3.68557461
48signal transduction involved in DNA integrity checkpoint (GO:0072401)3.64975430
49signal transduction involved in DNA damage checkpoint (GO:0072422)3.64975430
50oxidative phosphorylation (GO:0006119)3.63847288
51ribosome assembly (GO:0042255)3.61290872
52signal transduction involved in cell cycle checkpoint (GO:0072395)3.60193623
53proteasome assembly (GO:0043248)3.59204761
54rRNA modification (GO:0000154)3.58993543
55protein neddylation (GO:0045116)3.57120401
56positive regulation of ligase activity (GO:0051351)3.55800105
57nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.54106771
58regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.52511304
59metaphase plate congression (GO:0051310)3.51578017
60regulation of nuclear cell cycle DNA replication (GO:0033262)3.51540704
61establishment of protein localization to mitochondrion (GO:0072655)3.49929479
62exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.49844904
63kinetochore assembly (GO:0051382)3.48780578
64viral transcription (GO:0019083)3.47668234
65rRNA processing (GO:0006364)3.47284194
66protein localization to mitochondrion (GO:0070585)3.46324897
67viral mRNA export from host cell nucleus (GO:0046784)3.45321729
68ribosomal small subunit biogenesis (GO:0042274)3.45149549
69DNA damage response, detection of DNA damage (GO:0042769)3.44868991
70mitotic recombination (GO:0006312)3.44720061
71translational termination (GO:0006415)3.44192609
72mitotic sister chromatid segregation (GO:0000070)3.43557196
73regulation of ubiquitin-protein transferase activity (GO:0051438)3.42290378
74protein localization to chromosome, centromeric region (GO:0071459)3.42278712
75CENP-A containing nucleosome assembly (GO:0034080)3.40887088
76* spliceosomal snRNP assembly (GO:0000387)3.40713466
77inner mitochondrial membrane organization (GO:0007007)3.39268253
78mitotic nuclear envelope disassembly (GO:0007077)3.39217473
79telomere maintenance via telomere lengthening (GO:0010833)3.39151886
80chromatin remodeling at centromere (GO:0031055)3.38500369
81rRNA metabolic process (GO:0016072)3.36910901
82kinetochore organization (GO:0051383)3.36384844
83translational initiation (GO:0006413)3.34958632
84cullin deneddylation (GO:0010388)3.33636784
85DNA replication-dependent nucleosome assembly (GO:0006335)3.32532045
86DNA replication-dependent nucleosome organization (GO:0034723)3.32532045
87regulation of ligase activity (GO:0051340)3.28766197
88respiratory chain complex IV assembly (GO:0008535)3.27552622
89pseudouridine synthesis (GO:0001522)3.25285836
90attachment of spindle microtubules to kinetochore (GO:0008608)3.23654238
91anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.23109814
92DNA unwinding involved in DNA replication (GO:0006268)3.22866897
93maturation of 5.8S rRNA (GO:0000460)3.22663643
94protein complex disassembly (GO:0043241)3.22093253
95transcription-coupled nucleotide-excision repair (GO:0006283)3.21923614
96termination of RNA polymerase III transcription (GO:0006386)3.20382938
97transcription elongation from RNA polymerase III promoter (GO:0006385)3.20382938
98nucleotide-excision repair, DNA gap filling (GO:0006297)3.19696621
99ATP biosynthetic process (GO:0006754)3.18624756
100translational elongation (GO:0006414)3.17866083
101spliceosomal complex assembly (GO:0000245)3.17129646
102regulation of double-strand break repair via homologous recombination (GO:0010569)3.16499933
103DNA replication-independent nucleosome assembly (GO:0006336)3.16311444
104DNA replication-independent nucleosome organization (GO:0034724)3.16311444
105negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.16094149
106regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.16082960
107purine nucleoside triphosphate biosynthetic process (GO:0009145)3.15432486
108establishment of chromosome localization (GO:0051303)3.14735491
109protein deneddylation (GO:0000338)3.14573144
110purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.13423340
111negative regulation of chromosome segregation (GO:0051985)3.12675214
112maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.12489740
113macromolecular complex disassembly (GO:0032984)3.11771003
114positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.10545881
115cytochrome complex assembly (GO:0017004)3.09024594
116nuclear envelope disassembly (GO:0051081)3.07421560
117membrane disassembly (GO:0030397)3.07421560
118tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.07091801
119RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.07091801
120regulation of spindle organization (GO:0090224)3.06166478
121negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.04565337
122negative regulation of sister chromatid segregation (GO:0033046)3.04565337
123negative regulation of mitotic sister chromatid separation (GO:2000816)3.04565337
124negative regulation of mitotic sister chromatid segregation (GO:0033048)3.04565337
125nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.02837394
126spindle checkpoint (GO:0031577)2.99271067
127spindle assembly checkpoint (GO:0071173)2.97292942
128termination of RNA polymerase I transcription (GO:0006363)2.97237995
129mitotic spindle assembly checkpoint (GO:0007094)2.97038627
130transcription from RNA polymerase I promoter (GO:0006360)2.96803017
131IMP biosynthetic process (GO:0006188)2.96794128
132regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.95784721
133negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.94301078
134positive regulation of chromosome segregation (GO:0051984)2.91855064
135negative regulation of ligase activity (GO:0051352)2.89953804
136negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.89953804
137regulation of mitotic metaphase/anaphase transition (GO:0030071)2.89797463
138sister chromatid segregation (GO:0000819)2.88976776
139mitotic spindle checkpoint (GO:0071174)2.88339268
140DNA-templated transcription, termination (GO:0006353)2.88276260
141termination of RNA polymerase II transcription (GO:0006369)2.87942827
142folic acid-containing compound biosynthetic process (GO:0009396)2.87565676
1437-methylguanosine mRNA capping (GO:0006370)2.87541460
144regulation of chromosome segregation (GO:0051983)2.85511432
145histone exchange (GO:0043486)2.85367229
146rRNA methylation (GO:0031167)2.85080309
147SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.85013719
148transcription elongation from RNA polymerase I promoter (GO:0006362)2.84155825
149translation (GO:0006412)2.83941823
150positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.83863274
151cellular component biogenesis (GO:0044085)2.83227259
152protein K6-linked ubiquitination (GO:0085020)2.83007123
153replication fork processing (GO:0031297)2.82322834
154regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.82201624
155deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.82033810

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.05595613
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.21757910
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.75647957
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.49383695
5* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.24783779
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.22686926
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.11859685
8MYC_19079543_ChIP-ChIP_MESCs_Mouse3.03706803
9* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.03120361
10* ETS1_20019798_ChIP-Seq_JURKAT_Human2.95575133
11* EST1_17652178_ChIP-ChIP_JURKAT_Human2.92452274
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.89249682
13* GABP_17652178_ChIP-ChIP_JURKAT_Human2.87756034
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.87259499
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.68499541
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.48199403
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.45879552
18XRN2_22483619_ChIP-Seq_HELA_Human2.37672855
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.36286597
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.26482146
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.22988346
22VDR_23849224_ChIP-Seq_CD4+_Human2.22211819
23* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.03503531
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.01306355
25MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.99750513
26DCP1A_22483619_ChIP-Seq_HELA_Human1.98228346
27* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.93036382
28* FOXP3_21729870_ChIP-Seq_TREG_Human1.92594853
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.92556982
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.90822000
31* GABP_19822575_ChIP-Seq_HepG2_Human1.90095243
32THAP11_20581084_ChIP-Seq_MESCs_Mouse1.86901615
33YY1_21170310_ChIP-Seq_MESCs_Mouse1.85818590
34TTF2_22483619_ChIP-Seq_HELA_Human1.82898148
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.82026983
36MYCN_18555785_ChIP-Seq_MESCs_Mouse1.80495327
37E2F1_21310950_ChIP-Seq_MCF-7_Human1.70910892
38AR_21909140_ChIP-Seq_LNCAP_Human1.70276126
39TP63_19390658_ChIP-ChIP_HaCaT_Human1.69855600
40* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.64186751
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56491521
42CIITA_25753668_ChIP-Seq_RAJI_Human1.55491640
43SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.53999573
44ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.52505735
45CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.51836283
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51092142
47TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.50599245
48CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.49155053
49KDM5A_27292631_Chip-Seq_BREAST_Human1.45845747
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.45083372
51POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.44931054
52* ELK1_19687146_ChIP-ChIP_HELA_Human1.44429905
53MYC_22102868_ChIP-Seq_BL_Human1.43059612
54POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.42451213
55SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.40862436
56SRF_21415370_ChIP-Seq_HL-1_Mouse1.40818367
57ZFX_18555785_ChIP-Seq_MESCs_Mouse1.40460440
58TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.40457333
59CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.39775584
60* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.38165693
61EGR1_19374776_ChIP-ChIP_THP-1_Human1.37516365
62NOTCH1_21737748_ChIP-Seq_TLL_Human1.34976197
63KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.34299242
64KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.34299242
65KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.34299242
66STAT3_1855785_ChIP-Seq_MESCs_Mouse1.34292179
67HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31758514
68* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.28231545
69* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.27211627
70KLF4_18555785_ChIP-Seq_MESCs_Mouse1.25580945
71DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.24801214
72SOX2_18555785_ChIP-Seq_MESCs_Mouse1.24618916
73HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.23431491
74MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22951640
75KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.22033842
76KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.20335271
77HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.16212627
78CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.14876852
79DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.10885147
80ERG_20887958_ChIP-Seq_HPC-7_Mouse1.07789181
81ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07649012
82TCF3_18692474_ChIP-Seq_MEFs_Mouse1.06440567
83* TFEB_21752829_ChIP-Seq_HELA_Human1.06317860
84BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.06175369
85SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.05397801
86ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04113632
87E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03320583
88CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.03054437
89NANOG_16153702_ChIP-ChIP_HESCs_Human1.02396819
90CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00582318
91SOX2_16153702_ChIP-ChIP_HESCs_Human0.99800344
92NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.99219200
93NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.97839856
94NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.97384715
95* ELK1_22589737_ChIP-Seq_MCF10A_Human0.95456704
96CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.95426140
97VDR_21846776_ChIP-Seq_THP-1_Human0.95356586
98PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95214730
99ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.94501353
100NANOG_21062744_ChIP-ChIP_HESCs_Human0.94202144
101* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.92978040
102PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.92757321
103SOX2_18692474_ChIP-Seq_MEFs_Mouse0.92682252
104TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91738525
105ZNF263_19887448_ChIP-Seq_K562_Human0.91626748
106MYC_18940864_ChIP-ChIP_HL60_Human0.90802761
107SOX17_20123909_ChIP-Seq_XEN_Mouse0.90579814
108SPI1_23547873_ChIP-Seq_NB4_Human0.90398443
109OCT4_18692474_ChIP-Seq_MEFs_Mouse0.89979451
110* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.87878838
111HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.87699822
112CTCF_18555785_ChIP-Seq_MESCs_Mouse0.85799314
113SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.85608735
114POU5F1_16153702_ChIP-ChIP_HESCs_Human0.78116021
115FOXP1_21924763_ChIP-Seq_HESCs_Human0.77193248
116PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.69041122
117CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.68531470
118* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.67509329
119* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.66711687
120EWS_26573619_Chip-Seq_HEK293_Human0.66428920

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.35555157
2MP0003111_abnormal_nucleus_morphology4.50653749
3MP0010094_abnormal_chromosome_stability4.05677449
4MP0004957_abnormal_blastocyst_morpholog4.05388181
5MP0003077_abnormal_cell_cycle3.82235711
6MP0009379_abnormal_foot_pigmentation3.74238617
7MP0008057_abnormal_DNA_replication3.56129061
8MP0008058_abnormal_DNA_repair3.40680206
9MP0008007_abnormal_cellular_replicative2.85995756
10MP0008932_abnormal_embryonic_tissue2.72507558
11MP0003786_premature_aging2.26749459
12MP0001529_abnormal_vocalization2.22159920
13MP0006036_abnormal_mitochondrial_physio2.21435670
14MP0009697_abnormal_copulation2.13657952
15MP0006035_abnormal_mitochondrial_morpho2.09068773
16MP0000372_irregular_coat_pigmentation2.06159026
17MP0000350_abnormal_cell_proliferation2.05394300
18MP0001730_embryonic_growth_arrest2.01610953
19MP0003123_paternal_imprinting2.01412018
20MP0010030_abnormal_orbit_morphology1.93743506
21MP0003718_maternal_effect1.89076817
22MP0006292_abnormal_olfactory_placode1.86954063
23MP0002396_abnormal_hematopoietic_system1.86909734
24MP0008877_abnormal_DNA_methylation1.82761887
25MP0000490_abnormal_crypts_of1.74204253
26MP0005380_embryogenesis_phenotype1.71810494
27MP0001672_abnormal_embryogenesis/_devel1.71810494
28MP0009333_abnormal_splenocyte_physiolog1.62470407
29MP0001697_abnormal_embryo_size1.57508190
30MP0010307_abnormal_tumor_latency1.55563632
31MP0002085_abnormal_embryonic_tissue1.53669158
32MP0010352_gastrointestinal_tract_polyps1.52084383
33MP0003984_embryonic_growth_retardation1.48880051
34MP0000313_abnormal_cell_death1.45992052
35MP0002088_abnormal_embryonic_growth/wei1.45678280
36MP0002080_prenatal_lethality1.44999400
37MP0004147_increased_porphyrin_level1.43241790
38MP0006072_abnormal_retinal_apoptosis1.36136856
39MP0002653_abnormal_ependyma_morphology1.35844623
40MP0002019_abnormal_tumor_incidence1.35573870
41MP0005408_hypopigmentation1.35181992
42MP0003567_abnormal_fetal_cardiomyocyte1.32109238
43MP0003315_abnormal_perineum_morphology1.31604845
44MP0001545_abnormal_hematopoietic_system1.31311315
45MP0005397_hematopoietic_system_phenotyp1.31311315
46MP0001293_anophthalmia1.30609125
47MP0003941_abnormal_skin_development1.28326478
48MP0002086_abnormal_extraembryonic_tissu1.27926501
49MP0002084_abnormal_developmental_patter1.27839563
50MP0004808_abnormal_hematopoietic_stem1.26134003
51MP0002132_abnormal_respiratory_system1.25741760
52MP0009278_abnormal_bone_marrow1.25562995
53MP0002210_abnormal_sex_determination1.24641590
54MP0004197_abnormal_fetal_growth/weight/1.24021584
55MP0004133_heterotaxia1.23597601
56MP0003890_abnormal_embryonic-extraembry1.23184962
57MP0005499_abnormal_olfactory_system1.18717986
58MP0005394_taste/olfaction_phenotype1.18717986
59MP0002163_abnormal_gland_morphology1.18263415
60MP0005084_abnormal_gallbladder_morpholo1.17090428
61MP0003119_abnormal_digestive_system1.10601798
62MP0002160_abnormal_reproductive_system1.10131006
63MP0001145_abnormal_male_reproductive1.09716246
64MP0003763_abnormal_thymus_physiology1.08961362
65MP0000703_abnormal_thymus_morphology1.05774938
66MP0002234_abnormal_pharynx_morphology1.04231916
67MP0001764_abnormal_homeostasis1.03097043
68MP0002736_abnormal_nociception_after1.02343300
69MP0005076_abnormal_cell_differentiation0.99480749
70MP0005389_reproductive_system_phenotype0.98496008
71MP0002722_abnormal_immune_system0.96418950
72MP0002111_abnormal_tail_morphology0.96168023
73MP0002837_dystrophic_cardiac_calcinosis0.95864127
74MP0002398_abnormal_bone_marrow0.95644214
75MP0001929_abnormal_gametogenesis0.95241418
76MP0003011_delayed_dark_adaptation0.93089763
77MP0000858_altered_metastatic_potential0.92700016
78MP0003121_genomic_imprinting0.92153399
79MP0000689_abnormal_spleen_morphology0.91686633
80MP0008260_abnormal_autophagy0.91465838
81MP0005075_abnormal_melanosome_morpholog0.91141484
82MP0000653_abnormal_sex_gland0.89411686
83MP0001119_abnormal_female_reproductive0.89217751
84MP0001727_abnormal_embryo_implantation0.87630751
85MP0002233_abnormal_nose_morphology0.86181320
86MP0002697_abnormal_eye_size0.86062730
87MP0003806_abnormal_nucleotide_metabolis0.84372253
88MP0001905_abnormal_dopamine_level0.83908075
89MP0000631_abnormal_neuroendocrine_gland0.83395366
90MP0000647_abnormal_sebaceous_gland0.82890787
91MP0001286_abnormal_eye_development0.82407523
92MP0002095_abnormal_skin_pigmentation0.82271759
93MP0002102_abnormal_ear_morphology0.80964346
94MP0004142_abnormal_muscle_tone0.80905924
95MP0001919_abnormal_reproductive_system0.80707320
96MP0003186_abnormal_redox_activity0.79466883
97MP0002277_abnormal_respiratory_mucosa0.78998651
98MP0001346_abnormal_lacrimal_gland0.77960474
99MP0000358_abnormal_cell_content/0.76836335
100MP0002429_abnormal_blood_cell0.76161624
101MP0000049_abnormal_middle_ear0.75991809
102MP0000566_synostosis0.74501078
103MP0000428_abnormal_craniofacial_morphol0.74337180
104MP0002282_abnormal_trachea_morphology0.72757841
105MP0001881_abnormal_mammary_gland0.72718662
106MP0008995_early_reproductive_senescence0.71836442
107MP0003937_abnormal_limbs/digits/tail_de0.70430178
108MP0005384_cellular_phenotype0.69599578
109MP0008789_abnormal_olfactory_epithelium0.69399747
110MP0005379_endocrine/exocrine_gland_phen0.69124982
111MP0000750_abnormal_muscle_regeneration0.69057767
112MP0008875_abnormal_xenobiotic_pharmacok0.68672247
113MP0009672_abnormal_birth_weight0.67732937
114MP0005621_abnormal_cell_physiology0.66642213
115MP0003698_abnormal_male_reproductive0.66508863
116MP0002092_abnormal_eye_morphology0.66004101
117MP0002938_white_spotting0.65717492
118MP0003878_abnormal_ear_physiology0.65369799
119MP0005377_hearing/vestibular/ear_phenot0.65369799
120MP0000716_abnormal_immune_system0.64976307
121MP0002090_abnormal_vision0.64520525
122MP0005253_abnormal_eye_physiology0.64439405
123MP0009053_abnormal_anal_canal0.63958779
124MP0005391_vision/eye_phenotype0.63573321
125MP0002405_respiratory_system_inflammati0.62564560
126MP0000432_abnormal_head_morphology0.62528437
127MP0003136_yellow_coat_color0.62315069
128MP0005023_abnormal_wound_healing0.62181654
129MP0001853_heart_inflammation0.62075728
130MP0003938_abnormal_ear_development0.61911191
131MP0000537_abnormal_urethra_morphology0.61831308
132MP0005332_abnormal_amino_acid0.60869876
133MP0009703_decreased_birth_body0.60202584
134MP0004145_abnormal_muscle_electrophysio0.59958265
135MP0003448_altered_tumor_morphology0.59495101
136MP0002751_abnormal_autonomic_nervous0.56881201
137MP0000678_abnormal_parathyroid_gland0.56160371
138MP0002249_abnormal_larynx_morphology0.55943748

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.99056534
2Abnormal mitochondria in muscle tissue (HP:0008316)5.60007271
3Acute encephalopathy (HP:0006846)5.32927615
4Mitochondrial inheritance (HP:0001427)5.19007695
5Birth length less than 3rd percentile (HP:0003561)4.87913455
6Progressive macrocephaly (HP:0004481)4.84072654
7Increased CSF lactate (HP:0002490)4.82633656
8Hepatocellular necrosis (HP:0001404)4.66748183
9Increased hepatocellular lipid droplets (HP:0006565)4.50837329
10Breast hypoplasia (HP:0003187)4.31815246
11Hepatic necrosis (HP:0002605)4.26652914
12Chromosomal breakage induced by crosslinking agents (HP:0003221)4.22485323
13Reticulocytopenia (HP:0001896)4.18958890
14Lipid accumulation in hepatocytes (HP:0006561)4.07052571
15Cerebral edema (HP:0002181)3.99902116
16Chromsome breakage (HP:0040012)3.93996521
17Patellar aplasia (HP:0006443)3.75313646
18Renal Fanconi syndrome (HP:0001994)3.68891467
19Decreased activity of mitochondrial respiratory chain (HP:0008972)3.65906153
20Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.65906153
21Aplasia/Hypoplasia of the patella (HP:0006498)3.59319023
22Abnormality of cells of the erythroid lineage (HP:0012130)3.50553272
23Meckel diverticulum (HP:0002245)3.43155248
24Increased intramyocellular lipid droplets (HP:0012240)3.41044319
25Abnormal number of erythroid precursors (HP:0012131)3.40326161
26Abnormality of the ileum (HP:0001549)3.40031017
27Increased serum lactate (HP:0002151)3.34786026
28Absent radius (HP:0003974)3.26828901
29Carpal bone hypoplasia (HP:0001498)3.25562752
30Lactic acidosis (HP:0003128)3.24656302
31Rough bone trabeculation (HP:0100670)3.23598383
32Increased serum pyruvate (HP:0003542)3.21573094
33Abnormality of the anterior horn cell (HP:0006802)3.20892268
34Degeneration of anterior horn cells (HP:0002398)3.20892268
35Oral leukoplakia (HP:0002745)3.16007823
36Absent thumb (HP:0009777)3.13926240
37Exercise intolerance (HP:0003546)3.10998427
38Abnormality of the preputium (HP:0100587)3.09063452
39Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.08818621
40Respiratory failure (HP:0002878)3.06942589
41Aplasia involving forearm bones (HP:0009822)3.03322631
42Absent forearm bone (HP:0003953)3.03322631
43Aplasia/Hypoplasia of the uvula (HP:0010293)3.01252802
44Selective tooth agenesis (HP:0001592)2.98909050
45Abnormality of glycolysis (HP:0004366)2.94674675
46Impulsivity (HP:0100710)2.92239461
473-Methylglutaconic aciduria (HP:0003535)2.86562967
48Leukodystrophy (HP:0002415)2.85093560
49Trismus (HP:0000211)2.81908115
50Cerebral hypomyelination (HP:0006808)2.81466153
51Exertional dyspnea (HP:0002875)2.80165000
52Abnormality of chromosome stability (HP:0003220)2.77370974
53Increased muscle lipid content (HP:0009058)2.77035458
54Respiratory difficulties (HP:0002880)2.72659367
55Microvesicular hepatic steatosis (HP:0001414)2.70152311
56Premature graying of hair (HP:0002216)2.66819038
57Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.65052176
58Optic disc pallor (HP:0000543)2.63526097
59Pallor (HP:0000980)2.63514889
60Supernumerary spleens (HP:0009799)2.58917412
61Bone marrow hypocellularity (HP:0005528)2.58778554
62Aplastic anemia (HP:0001915)2.57630270
63Macrocytic anemia (HP:0001972)2.56503708
64Myelodysplasia (HP:0002863)2.52714316
65Small intestinal stenosis (HP:0012848)2.49178732
66Duodenal stenosis (HP:0100867)2.49178732
67Cleft eyelid (HP:0000625)2.48586699
68Aplasia/Hypoplasia of the sacrum (HP:0008517)2.48552836
69Triphalangeal thumb (HP:0001199)2.47062534
70Duplicated collecting system (HP:0000081)2.46255279
71Microretrognathia (HP:0000308)2.41891688
72Abnormal trabecular bone morphology (HP:0100671)2.41093936
73Lethargy (HP:0001254)2.40231523
74Colon cancer (HP:0003003)2.38185872
75Tracheoesophageal fistula (HP:0002575)2.37183261
76Premature ovarian failure (HP:0008209)2.36791293
77Medulloblastoma (HP:0002885)2.36272955
78Horseshoe kidney (HP:0000085)2.33237987
79Neoplasm of the pancreas (HP:0002894)2.32889301
80Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.32515201
81Multiple enchondromatosis (HP:0005701)2.24342428
82Abnormality of the renal collecting system (HP:0004742)2.21555696
83Ectopic kidney (HP:0000086)2.18475440
84CNS demyelination (HP:0007305)2.18098124
85Secondary amenorrhea (HP:0000869)2.14779376
86Hyperglycinemia (HP:0002154)2.14317023
87Ureteral duplication (HP:0000073)2.12536565
88Atresia of the external auditory canal (HP:0000413)2.12457506
89Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.12302486
90Abnormal protein N-linked glycosylation (HP:0012347)2.12302486
91Abnormal protein glycosylation (HP:0012346)2.12302486
92Abnormal glycosylation (HP:0012345)2.12302486
93Ependymoma (HP:0002888)2.11100647
94Abnormality of renal resorption (HP:0011038)2.09667236
95Abnormality of the duodenum (HP:0002246)2.09622733
96Short thumb (HP:0009778)2.08049524
97Abnormality of the labia minora (HP:0012880)2.07869519
98Abnormal lung lobation (HP:0002101)2.07526634
99Cellular immunodeficiency (HP:0005374)2.05827496
100Sloping forehead (HP:0000340)2.05028621
101Abnormality of alanine metabolism (HP:0010916)2.04978513
102Hyperalaninemia (HP:0003348)2.04978513
103Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.04978513
104Generalized aminoaciduria (HP:0002909)2.03836849
105Hypoplasia of the radius (HP:0002984)2.03390331
106Overlapping toe (HP:0001845)2.03389325
107Rib fusion (HP:0000902)2.02945599
108Abnormal number of incisors (HP:0011064)2.01351396
109Rhabdomyosarcoma (HP:0002859)1.99581768
110Abnormality of methionine metabolism (HP:0010901)1.99490092
111Agnosia (HP:0010524)1.98497847
112X-linked dominant inheritance (HP:0001423)1.98004116
113Sparse eyelashes (HP:0000653)1.95431895
114Muscle fiber atrophy (HP:0100295)1.95337817
115Emotional lability (HP:0000712)1.93590816
11611 pairs of ribs (HP:0000878)1.93533177
117Reduced antithrombin III activity (HP:0001976)1.92549111
118Congenital, generalized hypertrichosis (HP:0004540)1.92424405
119Methylmalonic aciduria (HP:0012120)1.92243906
120Aplasia/hypoplasia of the humerus (HP:0006507)1.92187130
121Squamous cell carcinoma (HP:0002860)1.91907118
122Tongue fasciculations (HP:0001308)1.91382652
123Type I transferrin isoform profile (HP:0003642)1.89812830
124Abnormality of serum amino acid levels (HP:0003112)1.88933873
125Glycosuria (HP:0003076)1.88498903
126Abnormality of urine glucose concentration (HP:0011016)1.88498903
127Clubbing of toes (HP:0100760)1.88342598
128Methylmalonic acidemia (HP:0002912)1.88024164
129Abnormality of DNA repair (HP:0003254)1.83360854
130Slender long bone (HP:0003100)1.82941251
131Abnormality of the carotid arteries (HP:0005344)1.82799784
132Breast aplasia (HP:0100783)1.79765671
133Progressive muscle weakness (HP:0003323)1.78498107
134Aplasia/Hypoplasia involving the musculature (HP:0001460)1.78489203
135Atrophy/Degeneration involving motor neurons (HP:0007373)1.78304820
136Abnormality of abdominal situs (HP:0011620)1.77883534
137Abdominal situs inversus (HP:0003363)1.77883534
138Testicular atrophy (HP:0000029)1.76814656
139Abnormality of the umbilical cord (HP:0010881)1.76657150
140Pancytopenia (HP:0001876)1.76271293
141Lymphoma (HP:0002665)1.75792883
142Pancreatic fibrosis (HP:0100732)1.75783566
143Type 2 muscle fiber atrophy (HP:0003554)1.75285090
144Rectal fistula (HP:0100590)1.75039527
145Rectovaginal fistula (HP:0000143)1.75039527
146Breech presentation (HP:0001623)1.74840993
147Sclerocornea (HP:0000647)1.74207826
148Spinal muscular atrophy (HP:0007269)1.73944323
149Aplasia/Hypoplasia of the breasts (HP:0010311)1.73144391
150Facial hemangioma (HP:0000329)1.72968382
151Facial cleft (HP:0002006)1.72793424
152Hyperphosphaturia (HP:0003109)1.72373668
153Abnormality of placental membranes (HP:0011409)1.71963346
154Amniotic constriction ring (HP:0009775)1.71963346
155Blindness (HP:0000618)1.71013028
156Muscle fibrillation (HP:0010546)1.70221859
157Septo-optic dysplasia (HP:0100842)1.70221740
158Hypoplastic pelvis (HP:0008839)1.69434864
159Basal cell carcinoma (HP:0002671)1.68354095
160Pancreatic cysts (HP:0001737)1.67504826
161Absent septum pellucidum (HP:0001331)1.64968800
162Nephroblastoma (Wilms tumor) (HP:0002667)1.63228935
163Poor head control (HP:0002421)1.62862698

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.24487179
2BUB15.04979227
3WEE13.93167051
4NEK13.25460054
5NEK23.14465423
6CDC72.75858003
7EIF2AK12.62471361
8PLK42.62301984
9NME22.51821359
10SRPK12.44948820
11TTK2.33195226
12STK162.27789418
13TESK22.25583746
14DYRK32.09097792
15PLK12.01926965
16EPHA21.94402707
17CDK71.83668696
18ACVR1B1.81518051
19BRSK21.77343956
20TLK11.73953507
21TSSK61.71915332
22ZAK1.68221242
23TRIM281.66445482
24PDK21.64516160
25VRK11.62310107
26NUAK11.59854821
27PIM21.58176324
28AURKB1.58163454
29EIF2AK31.53056242
30RPS6KA41.49891048
31MKNK11.49460648
32MKNK21.47775903
33ATR1.47552683
34CHEK21.46390601
35TAF11.45329720
36IRAK31.43964690
37CDK121.41640809
38AURKA1.34802978
39PLK31.32557558
40RPS6KB21.30106002
41MAP3K81.15223045
42TAOK21.12811367
43BRSK11.11924635
44STK101.10958859
45TESK11.10682655
46PASK1.10261379
47PIM11.09910605
48MAP3K121.05974954
49STK41.05155879
50CDK41.05106403
51MAP3K111.04774675
52CHEK11.02553071
53STK38L0.98247506
54WNK30.98147838
55PAK40.94621295
56AKT30.92967476
57MAP4K20.89822565
58LATS20.88724573
59CSNK1G30.88456629
60CDK190.86836650
61EIF2AK20.86088962
62MAP3K100.84794143
63KDR0.83079361
64BRAF0.80237721
65BMPR1B0.79393217
66CDK20.74321247
67PRKCI0.73358190
68PAK10.73107260
69CSNK1G10.72659120
70DYRK20.71780898
71CDK80.70639804
72DAPK10.70256684
73CCNB10.69039679
74CSNK2A10.68865541
75ATM0.67051748
76RPS6KA50.63501947
77CSNK2A20.60890322
78CSNK1G20.60679310
79BLK0.60648990
80IRAK40.59484202
81YES10.58786749
82ILK0.58768988
83STK30.58555993
84ABL20.58308487
85CSNK1A1L0.57233021
86IKBKB0.56554670
87LRRK20.54803371
88MAPKAPK30.52322916
89MAP4K10.52132463
90CDK10.49871364
91EEF2K0.48286317
92PNCK0.47918679
93TNIK0.47679499
94DAPK30.46299992
95ALK0.44491633
96CHUK0.43376750
97MAP2K70.42557375
98PBK0.42551462
99SCYL20.41501972
100MAP2K20.41194099
101AKT20.40379817
102MAPKAPK50.38561889
103TGFBR10.37659765
104BCKDK0.37380871
105BCR0.37052215
106CDK60.36511569
107MELK0.35129778
108BRD40.34630491
109WNK40.34188680
110ZAP700.32591272
111MTOR0.32480516
112LIMK10.30942438
113MARK30.29980552
114GRK10.29660008
115MAPKAPK20.29475224
116CDK140.29162877
117CLK10.28972132
118FLT30.28896222
119ICK0.28495533
120CDK11A0.28487482
121ERBB40.28362785
122PLK20.28012410
123RPS6KC10.27751279
124RPS6KL10.27751279
125NME10.27230313
126ARAF0.27136996
127RPS6KA60.26975521
128CDK180.26864051
129MYLK0.26820321
130CDK30.26696079
131MST40.26368865
132MATK0.26100887
133JAK30.25514710
134CDK150.24917404
135INSRR0.24337087
136NLK0.23168794
137CSNK1E0.23018622
138CSNK1A10.22792483

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.47997535
2Mismatch repair_Homo sapiens_hsa034303.92099966
3Oxidative phosphorylation_Homo sapiens_hsa001903.90074097
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.76016123
5Ribosome_Homo sapiens_hsa030103.59838287
6RNA polymerase_Homo sapiens_hsa030203.57586415
7Proteasome_Homo sapiens_hsa030503.35748372
8* Spliceosome_Homo sapiens_hsa030403.30603107
9Base excision repair_Homo sapiens_hsa034103.11692744
10RNA transport_Homo sapiens_hsa030133.06488460
11Homologous recombination_Homo sapiens_hsa034402.97262050
12Nucleotide excision repair_Homo sapiens_hsa034202.75524998
13Cell cycle_Homo sapiens_hsa041102.58498557
14Pyrimidine metabolism_Homo sapiens_hsa002402.52903471
15Fanconi anemia pathway_Homo sapiens_hsa034602.45559779
16One carbon pool by folate_Homo sapiens_hsa006702.29345984
17Alzheimers disease_Homo sapiens_hsa050102.22537107
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.13669206
19Basal transcription factors_Homo sapiens_hsa030222.07345646
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.94439906
21mRNA surveillance pathway_Homo sapiens_hsa030151.79407411
22p53 signaling pathway_Homo sapiens_hsa041151.76171363
23RNA degradation_Homo sapiens_hsa030181.70972564
24Vitamin B6 metabolism_Homo sapiens_hsa007501.55501219
25Non-homologous end-joining_Homo sapiens_hsa034501.52552351
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.49963537
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.49127793
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.48126428
29Cardiac muscle contraction_Homo sapiens_hsa042601.44787817
30Pyruvate metabolism_Homo sapiens_hsa006201.33155614
31Purine metabolism_Homo sapiens_hsa002301.32891862
32Fatty acid elongation_Homo sapiens_hsa000621.30502821
33Epstein-Barr virus infection_Homo sapiens_hsa051691.28408115
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.23005013
35Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.18347515
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.17547898
37Sulfur relay system_Homo sapiens_hsa041221.09600813
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.08554355
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.06815908
40Propanoate metabolism_Homo sapiens_hsa006401.06163012
41Folate biosynthesis_Homo sapiens_hsa007901.03939621
42Herpes simplex infection_Homo sapiens_hsa051681.01687500
43Steroid biosynthesis_Homo sapiens_hsa001000.93010244
44Pentose phosphate pathway_Homo sapiens_hsa000300.84852259
45Viral carcinogenesis_Homo sapiens_hsa052030.84656459
46Systemic lupus erythematosus_Homo sapiens_hsa053220.83374556
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.83373166
48Antigen processing and presentation_Homo sapiens_hsa046120.83271331
49HTLV-I infection_Homo sapiens_hsa051660.75235652
50Oocyte meiosis_Homo sapiens_hsa041140.72539492
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70086308
52Legionellosis_Homo sapiens_hsa051340.65734996
53Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63296640
54Primary immunodeficiency_Homo sapiens_hsa053400.62753679
55Drug metabolism - other enzymes_Homo sapiens_hsa009830.62170795
56Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.60682249
57Selenocompound metabolism_Homo sapiens_hsa004500.60674607
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.59720185
59Peroxisome_Homo sapiens_hsa041460.59016962
60Sulfur metabolism_Homo sapiens_hsa009200.57044274
61Notch signaling pathway_Homo sapiens_hsa043300.56711871
62Biosynthesis of amino acids_Homo sapiens_hsa012300.56081367
63Apoptosis_Homo sapiens_hsa042100.55244753
64MicroRNAs in cancer_Homo sapiens_hsa052060.55029166
65Measles_Homo sapiens_hsa051620.55007527
66Huntingtons disease_Homo sapiens_hsa050160.54784802
67Protein export_Homo sapiens_hsa030600.54178268
68NF-kappa B signaling pathway_Homo sapiens_hsa040640.53616898
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.53374670
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53089914
71Hippo signaling pathway_Homo sapiens_hsa043900.53087366
72Basal cell carcinoma_Homo sapiens_hsa052170.52523612
73Glutathione metabolism_Homo sapiens_hsa004800.50745481
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49901576
75Thyroid cancer_Homo sapiens_hsa052160.49800410
76Butanoate metabolism_Homo sapiens_hsa006500.48299486
77Regulation of autophagy_Homo sapiens_hsa041400.47961382
78Small cell lung cancer_Homo sapiens_hsa052220.47714010
79Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46856145
80Intestinal immune network for IgA production_Homo sapiens_hsa046720.46696555
81Fructose and mannose metabolism_Homo sapiens_hsa000510.45727970
82Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45639966
83Shigellosis_Homo sapiens_hsa051310.44992678
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44874531
85Hedgehog signaling pathway_Homo sapiens_hsa043400.40327480
86TGF-beta signaling pathway_Homo sapiens_hsa043500.38686979
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38507618
88Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.37822718
89Tyrosine metabolism_Homo sapiens_hsa003500.37761358
90Fatty acid metabolism_Homo sapiens_hsa012120.35913014
91Arachidonic acid metabolism_Homo sapiens_hsa005900.35708594
92Hepatitis B_Homo sapiens_hsa051610.35444619
93Collecting duct acid secretion_Homo sapiens_hsa049660.35333960
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34590577
95RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.32192728
96Bladder cancer_Homo sapiens_hsa052190.31800170
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30978386
98Influenza A_Homo sapiens_hsa051640.30863165
99Colorectal cancer_Homo sapiens_hsa052100.30013075
100Acute myeloid leukemia_Homo sapiens_hsa052210.29584015
101Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.28796818
102Tryptophan metabolism_Homo sapiens_hsa003800.28715317
103Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26012805
104Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.25823049
105Fatty acid degradation_Homo sapiens_hsa000710.25610936
106Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.25336549
107Galactose metabolism_Homo sapiens_hsa000520.25225094
108Graft-versus-host disease_Homo sapiens_hsa053320.24904899
109Hematopoietic cell lineage_Homo sapiens_hsa046400.24220269
110Pathways in cancer_Homo sapiens_hsa052000.23911020
111Allograft rejection_Homo sapiens_hsa053300.22205598
112beta-Alanine metabolism_Homo sapiens_hsa004100.22197296
113Phenylalanine metabolism_Homo sapiens_hsa003600.21805318
114Phototransduction_Homo sapiens_hsa047440.21499867
115Metabolic pathways_Homo sapiens_hsa011000.21105730
116NOD-like receptor signaling pathway_Homo sapiens_hsa046210.20971627
117Maturity onset diabetes of the young_Homo sapiens_hsa049500.20558430
118Vitamin digestion and absorption_Homo sapiens_hsa049770.20463099
119Chemical carcinogenesis_Homo sapiens_hsa052040.20229926
120Parkinsons disease_Homo sapiens_hsa050120.19957431
121Primary bile acid biosynthesis_Homo sapiens_hsa001200.19147226
122HIF-1 signaling pathway_Homo sapiens_hsa040660.19066776
123Chronic myeloid leukemia_Homo sapiens_hsa052200.18597869
124Arginine and proline metabolism_Homo sapiens_hsa003300.17653531
125Carbon metabolism_Homo sapiens_hsa012000.16796583
126Asthma_Homo sapiens_hsa053100.16434258
127Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.16184683
128Jak-STAT signaling pathway_Homo sapiens_hsa046300.15655679
129Fat digestion and absorption_Homo sapiens_hsa049750.15353605
130Prostate cancer_Homo sapiens_hsa052150.14888507
131Wnt signaling pathway_Homo sapiens_hsa043100.14700073
132Vibrio cholerae infection_Homo sapiens_hsa051100.14577742
133Leishmaniasis_Homo sapiens_hsa051400.14429183
134Alcoholism_Homo sapiens_hsa050340.14295283
135Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.14204374
136Nitrogen metabolism_Homo sapiens_hsa009100.14136962
137Adherens junction_Homo sapiens_hsa045200.13630260
138Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.12790295
139N-Glycan biosynthesis_Homo sapiens_hsa005100.12508786
140Caffeine metabolism_Homo sapiens_hsa002320.11537478
141Retinol metabolism_Homo sapiens_hsa008300.10022814
142Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.08029495
143SNARE interactions in vesicular transport_Homo sapiens_hsa041300.07462357

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