SNRPCP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine deamination (GO:0009972)8.74573031
2cytidine metabolic process (GO:0046087)8.74573031
3cytidine catabolic process (GO:0006216)8.74573031
4DNA deamination (GO:0045006)8.64639540
5pyrimidine ribonucleoside catabolic process (GO:0046133)7.81780394
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450917.75651125
7establishment of protein localization to mitochondrial membrane (GO:0090151)5.30905072
8positive regulation of interleukin-8 secretion (GO:2000484)5.22652347
9regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033395.14135943
10cytolysis (GO:0019835)5.05265951
11regulation of interleukin-12 biosynthetic process (GO:0045075)4.62680454
12positive regulation of interleukin-1 beta secretion (GO:0050718)4.46671193
13eosinophil chemotaxis (GO:0048245)4.34679127
14positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.33926720
15negative regulation by host of viral transcription (GO:0043922)4.32890749
16positive regulation of natural killer cell mediated immunity (GO:0002717)4.27769006
17DNA demethylation (GO:0080111)4.24339752
18Arp2/3 complex-mediated actin nucleation (GO:0034314)4.22745716
19positive regulation of interleukin-1 secretion (GO:0050716)4.20037902
20regulation of regulatory T cell differentiation (GO:0045589)4.14746694
21cellular response to interleukin-15 (GO:0071350)4.09780839
22regulation of cellular amino acid metabolic process (GO:0006521)4.04804346
23regulation of interleukin-1 beta secretion (GO:0050706)4.03637621
24tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.02009663
25RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.02009663
26regulation of isotype switching to IgG isotypes (GO:0048302)3.95788923
27negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.93975333
28response to interleukin-15 (GO:0070672)3.93266397
29regulation of interleukin-8 secretion (GO:2000482)3.92181043
30negative regulation of T cell apoptotic process (GO:0070233)3.91962748
31eosinophil migration (GO:0072677)3.91798077
32transcription elongation from RNA polymerase III promoter (GO:0006385)3.86028380
33termination of RNA polymerase III transcription (GO:0006386)3.86028380
34metallo-sulfur cluster assembly (GO:0031163)3.80347522
35iron-sulfur cluster assembly (GO:0016226)3.80347522
36DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.77748984
37signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.77665737
38signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.77665737
39signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.77665737
40actin nucleation (GO:0045010)3.72396668
41mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.70961591
42signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.68306988
43intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.68306988
44chaperone-mediated protein transport (GO:0072321)3.66131796
45regulation of natural killer cell mediated immunity (GO:0002715)3.63200570
46regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.63200570
47positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.62987760
48proteasome assembly (GO:0043248)3.62715258
49DNA dealkylation (GO:0035510)3.60829096
50signal transduction involved in DNA damage checkpoint (GO:0072422)3.60196385
51signal transduction involved in DNA integrity checkpoint (GO:0072401)3.60196385
52negative regulation of ligase activity (GO:0051352)3.56353044
53negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.56353044
54positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.54892713
55regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.54892713
56signal transduction involved in cell cycle checkpoint (GO:0072395)3.54260855
57regulation of interleukin-1 secretion (GO:0050704)3.51868868
58regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.50889236
59mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.50156790
60positive regulation of interleukin-1 beta production (GO:0032731)3.43169813
61antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.41516881
62protein-cofactor linkage (GO:0018065)3.40884633
63positive regulation of cell killing (GO:0031343)3.39056840
64pyrimidine nucleoside catabolic process (GO:0046135)3.35767062
65respiratory electron transport chain (GO:0022904)3.35589274
66positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.34016632
67positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.32662719
68rRNA modification (GO:0000154)3.30700494
69electron transport chain (GO:0022900)3.30429698
70anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.22759515
71negative regulation of metanephros development (GO:0072217)3.15259809
72antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.15250918
73regulation of interleukin-2 biosynthetic process (GO:0045076)3.13235400
74macrophage chemotaxis (GO:0048246)3.13146907
75protein neddylation (GO:0045116)3.09425343
76positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.07254314
77negative regulation of calcium ion transport into cytosol (GO:0010523)3.07013524
78positive regulation of cell cycle arrest (GO:0071158)3.04604149
79negative regulation of viral genome replication (GO:0045071)3.04590424
80protein complex biogenesis (GO:0070271)3.01421654
81ATP synthesis coupled proton transport (GO:0015986)3.00850340
82energy coupled proton transport, down electrochemical gradient (GO:0015985)3.00850340
83positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.96261411
84positive regulation of interleukin-1 production (GO:0032732)2.94962538
85positive regulation of interleukin-17 production (GO:0032740)2.93987013
86regulation of B cell receptor signaling pathway (GO:0050855)2.93574109
87inner mitochondrial membrane organization (GO:0007007)2.93136680
88regulation of cell killing (GO:0031341)2.90234497
89positive thymic T cell selection (GO:0045059)2.88606277
90positive regulation of chemokine biosynthetic process (GO:0045080)2.87202296
91positive regulation of defense response to virus by host (GO:0002230)2.86567112
92negative regulation of viral transcription (GO:0032897)2.82515483
93positive regulation of ligase activity (GO:0051351)2.82418426
94regulation of leukocyte mediated cytotoxicity (GO:0001910)2.80819986
95myeloid dendritic cell activation (GO:0001773)2.80647366
96rRNA methylation (GO:0031167)2.80580394
97regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.80290383
98regulation of mitochondrial translation (GO:0070129)2.78301921
99regulation of cellular amine metabolic process (GO:0033238)2.78231321
100regulation of activation of Janus kinase activity (GO:0010533)2.74981829

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.13116652
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.31953997
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.21171179
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.19564236
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.43256814
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.40810021
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.32014761
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.22150337
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.90170718
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.80093674
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.65328422
12VDR_22108803_ChIP-Seq_LS180_Human2.64362934
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.56016227
14VDR_23849224_ChIP-Seq_CD4+_Human2.36602930
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.27826390
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.14445604
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.07767815
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.06173442
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.04829127
20IRF8_21731497_ChIP-ChIP_J774_Mouse2.03435425
21ZNF274_21170338_ChIP-Seq_K562_Hela1.98701235
22STAT4_19710469_ChIP-ChIP_TH1__Mouse1.92513023
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.88984380
24HTT_18923047_ChIP-ChIP_STHdh_Human1.84728952
25ELF1_17652178_ChIP-ChIP_JURKAT_Human1.77562716
26STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.77116440
27SRF_21415370_ChIP-Seq_HL-1_Mouse1.74069007
28DCP1A_22483619_ChIP-Seq_HELA_Human1.73678191
29FOXP3_21729870_ChIP-Seq_TREG_Human1.69065195
30ELK1_19687146_ChIP-ChIP_HELA_Human1.67809671
31FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.66568613
32NOTCH1_21737748_ChIP-Seq_TLL_Human1.62352341
33FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.59284146
34LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.56403230
35HOXB4_20404135_ChIP-ChIP_EML_Mouse1.54185870
36IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.48347540
37YY1_21170310_ChIP-Seq_MESCs_Mouse1.48334461
38IRF8_22096565_ChIP-ChIP_GC-B_Human1.43633367
39PADI4_21655091_ChIP-ChIP_MCF-7_Human1.41525291
40PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.37794399
41SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.34550406
42MYB_26560356_Chip-Seq_TH2_Human1.34008179
43EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.24494176
44E2F4_17652178_ChIP-ChIP_JURKAT_Human1.24206321
45TP53_22573176_ChIP-Seq_HFKS_Human1.23597762
46TAF15_26573619_Chip-Seq_HEK293_Human1.23314860
47PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21523268
48NFE2_27457419_Chip-Seq_LIVER_Mouse1.16757402
49TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.15085413
50EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.14322022
51RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.11472236
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11006239
53AUTS2_25519132_ChIP-Seq_293T-REX_Human1.10837907
54CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.10468249
55IGF1R_20145208_ChIP-Seq_DFB_Human1.10436541
56GATA3_27048872_Chip-Seq_THYMUS_Human1.09478704
57SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09312494
58CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.08896373
59GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08729283
60TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.08037845
61FOXH1_21741376_ChIP-Seq_EPCs_Human1.07770566
62SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.07283913
63FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04691582
64STAT1_20625510_ChIP-Seq_HELA_Human1.02910635
65GABP_19822575_ChIP-Seq_HepG2_Human1.02123109
66EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01162848
67FOXA1_25329375_ChIP-Seq_VCAP_Human1.00566038
68FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00566038
69PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.00206593
70GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.99999926
71NCOR_22424771_ChIP-Seq_293T_Human0.99820151
72GBX2_23144817_ChIP-Seq_PC3_Human0.97941856
73PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.97298754
74AR_20517297_ChIP-Seq_VCAP_Human0.96863941
75GATA3_26560356_Chip-Seq_TH2_Human0.96712988
76TAF2_19829295_ChIP-Seq_ESCs_Human0.96678280
77HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.96185240
78ERG_20517297_ChIP-Seq_VCAP_Human0.94118433
79NANOG_19829295_ChIP-Seq_ESCs_Human0.93010556
80SOX2_19829295_ChIP-Seq_ESCs_Human0.93010556
81MYC_18358816_ChIP-ChIP_MESCs_Mouse0.92930978
82CTBP1_25329375_ChIP-Seq_LNCAP_Human0.92394163
83BCAT_22108803_ChIP-Seq_LS180_Human0.92318448
84P300_19829295_ChIP-Seq_ESCs_Human0.92035085
85GATA6_21074721_ChIP-Seq_CACO-2_Human0.91696335
86EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.91278925
87GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.91029019
88TTF2_22483619_ChIP-Seq_HELA_Human0.90638168
89SALL4_22934838_ChIP-ChIP_CD34+_Human0.90509573
90RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.90480326
91FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88757079
92CTBP2_25329375_ChIP-Seq_LNCAP_Human0.88192201
93TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.87423283
94E2F1_18555785_ChIP-Seq_MESCs_Mouse0.86897203
95CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86354544
96THAP11_20581084_ChIP-Seq_MESCs_Mouse0.86161534
97CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85551566
98MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.85527360
99RBPJ_21746931_ChIP-Seq_IB4_Human0.84503598
100IRF1_19129219_ChIP-ChIP_H3396_Human0.84253057

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.27512465
2MP0001835_abnormal_antigen_presentation3.90511667
3MP0009785_altered_susceptibility_to3.83271207
4MP0001873_stomach_inflammation3.16625880
5MP0009333_abnormal_splenocyte_physiolog3.04450713
6MP0005377_hearing/vestibular/ear_phenot2.85558013
7MP0003878_abnormal_ear_physiology2.85558013
8MP0006082_CNS_inflammation2.74910858
9MP0005000_abnormal_immune_tolerance2.43632002
10MP0003866_abnormal_defecation2.41243393
11MP0004782_abnormal_surfactant_physiolog2.40834369
12MP0010307_abnormal_tumor_latency2.33176438
13MP0002148_abnormal_hypersensitivity_rea2.29464744
14MP0003448_altered_tumor_morphology2.26209968
15MP0002138_abnormal_hepatobiliary_system2.10350529
16MP0006036_abnormal_mitochondrial_physio2.04250459
17MP0001800_abnormal_humoral_immune2.01515193
18MP0002876_abnormal_thyroid_physiology1.95493443
19MP0005387_immune_system_phenotype1.92165677
20MP0001790_abnormal_immune_system1.92165677
21MP0001958_emphysema1.87800149
22MP0003786_premature_aging1.83605282
23MP0006035_abnormal_mitochondrial_morpho1.81780362
24MP0010155_abnormal_intestine_physiology1.81222663
25MP0005310_abnormal_salivary_gland1.80695733
26MP0004145_abnormal_muscle_electrophysio1.75504189
27MP0002405_respiratory_system_inflammati1.69641866
28MP0002420_abnormal_adaptive_immunity1.64430685
29MP0002723_abnormal_immune_serum1.60922461
30MP0005025_abnormal_response_to1.60131691
31MP0001661_extended_life_span1.58889970
32MP0001819_abnormal_immune_cell1.56906826
33MP0004147_increased_porphyrin_level1.50998161
34MP0002006_tumorigenesis1.39983504
35MP0003763_abnormal_thymus_physiology1.37424880
36MP0001485_abnormal_pinna_reflex1.37217892
37MP0008875_abnormal_xenobiotic_pharmacok1.33634660
38MP0002166_altered_tumor_susceptibility1.31194051
39MP0002452_abnormal_antigen_presenting1.29714164
40MP0008877_abnormal_DNA_methylation1.28884396
41MP0001986_abnormal_taste_sensitivity1.24131258
42MP0000716_abnormal_immune_system1.23751041
43MP0005410_abnormal_fertilization1.21952731
44MP0003045_fibrosis1.17372779
45MP0003186_abnormal_redox_activity1.17363856
46MP0002822_catalepsy1.17064947
47MP0005075_abnormal_melanosome_morpholog1.15520696
48MP0002398_abnormal_bone_marrow1.15086490
49MP0001845_abnormal_inflammatory_respons1.14738702
50MP0002722_abnormal_immune_system1.14711099
51MP0000689_abnormal_spleen_morphology1.09722934
52MP0002429_abnormal_blood_cell1.03696274
53MP0003195_calcinosis1.02646190
54MP0002693_abnormal_pancreas_physiology1.02109605
55MP0002277_abnormal_respiratory_mucosa1.00838947
56MP0003137_abnormal_impulse_conducting1.00709021
57MP0001881_abnormal_mammary_gland0.99821389
58MP0008873_increased_physiological_sensi0.99566603
59MP0008469_abnormal_protein_level0.99196998
60MP0004142_abnormal_muscle_tone0.96311479
61MP0009765_abnormal_xenobiotic_induced0.96111193
62MP0003567_abnormal_fetal_cardiomyocyte0.95887511
63MP0002933_joint_inflammation0.93131442
64MP0005551_abnormal_eye_electrophysiolog0.92839049
65MP0001905_abnormal_dopamine_level0.92815528
66MP0006072_abnormal_retinal_apoptosis0.92683009
67MP0004957_abnormal_blastocyst_morpholog0.91258146
68MP0000703_abnormal_thymus_morphology0.90738891
69MP0005645_abnormal_hypothalamus_physiol0.88047215
70MP0008872_abnormal_physiological_respon0.87103979
71MP0006276_abnormal_autonomic_nervous0.85628660
72MP0002102_abnormal_ear_morphology0.85152568
73MP0001853_heart_inflammation0.85004743
74MP0002419_abnormal_innate_immunity0.84784278
75MP0009764_decreased_sensitivity_to0.84687938
76MP0004885_abnormal_endolymph0.84475866
77MP0005174_abnormal_tail_pigmentation0.82800040
78MP0005636_abnormal_mineral_homeostasis0.82688233
79MP0009763_increased_sensitivity_to0.81466166
80MP0001502_abnormal_circadian_rhythm0.81446930
81MP0002095_abnormal_skin_pigmentation0.80775113
82MP0005584_abnormal_enzyme/coenzyme_acti0.79818119
83MP0009745_abnormal_behavioral_response0.76368654
84MP0000358_abnormal_cell_content/0.75676662
85MP0008770_decreased_survivor_rate0.75635131
86MP0005319_abnormal_enzyme/_coenzyme0.75206350
87MP0001529_abnormal_vocalization0.74912803
88MP0004134_abnormal_chest_morphology0.74469907
89MP0002163_abnormal_gland_morphology0.72287914
90MP0005084_abnormal_gallbladder_morpholo0.69475188
91MP0003111_abnormal_nucleus_morphology0.68708587
92MP0003718_maternal_effect0.66398029
93MP0001984_abnormal_olfaction0.65579168
94MP0002019_abnormal_tumor_incidence0.63204455
95MP0001764_abnormal_homeostasis0.62776870
96MP0001119_abnormal_female_reproductive0.62600443
97MP0001919_abnormal_reproductive_system0.62190849
98MP0000569_abnormal_digit_pigmentation0.61122550
99MP0003011_delayed_dark_adaptation0.60779412
100MP0003936_abnormal_reproductive_system0.60502560

Predicted human phenotypes

RankGene SetZ-score
13-Methylglutaconic aciduria (HP:0003535)4.75034549
2Acute necrotizing encephalopathy (HP:0006965)4.72281105
3Mitochondrial inheritance (HP:0001427)4.60116126
4Abnormal mitochondria in muscle tissue (HP:0008316)4.30798659
5Decreased activity of mitochondrial respiratory chain (HP:0008972)4.26447857
6Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.26447857
7Hypoproteinemia (HP:0003075)4.07039578
8Hepatocellular necrosis (HP:0001404)4.01657333
9Progressive macrocephaly (HP:0004481)3.94510676
10Hepatic necrosis (HP:0002605)3.92979344
11Abnormal biliary tract physiology (HP:0012439)3.86604392
12Bile duct proliferation (HP:0001408)3.86604392
13Acute encephalopathy (HP:0006846)3.86071106
14Aplastic anemia (HP:0001915)3.86034981
15Increased intramyocellular lipid droplets (HP:0012240)3.85047331
16Increased CSF lactate (HP:0002490)3.81977297
17Cerebral edema (HP:0002181)3.67518519
18T lymphocytopenia (HP:0005403)3.44520717
19Pancreatic cysts (HP:0001737)3.42252199
20True hermaphroditism (HP:0010459)3.31233328
21Increased hepatocellular lipid droplets (HP:0006565)3.29684134
22Pancreatic fibrosis (HP:0100732)3.22303476
23Abnormality of T cell number (HP:0011839)3.20699698
24Zonular cataract (HP:0010920)3.17397256
25Renal Fanconi syndrome (HP:0001994)3.14232454
26Increased muscle lipid content (HP:0009058)3.05658321
27Increased serum lactate (HP:0002151)2.97664171
28Abnormality of midbrain morphology (HP:0002418)2.96532237
29Molar tooth sign on MRI (HP:0002419)2.96532237
30Lipid accumulation in hepatocytes (HP:0006561)2.84260550
31Generalized aminoaciduria (HP:0002909)2.84195224
32Abnormality of the prostate (HP:0008775)2.84031426
33Hemiplegia (HP:0002301)2.81629018
34Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.79561966
35Optic disc pallor (HP:0000543)2.69949144
36Lactic acidosis (HP:0003128)2.63271690
37Exercise intolerance (HP:0003546)2.61626190
38IgG deficiency (HP:0004315)2.60429106
39Exertional dyspnea (HP:0002875)2.51573792
40Increased IgM level (HP:0003496)2.48913839
41Abnormality of T cells (HP:0002843)2.39014132
42Abnormal albumin level (HP:0012116)2.37711752
43Hypoalbuminemia (HP:0003073)2.37711752
44Renal cortical cysts (HP:0000803)2.36726413
45Gastrointestinal infarctions (HP:0005244)2.28658062
46Leukodystrophy (HP:0002415)2.28237998
47Respiratory failure (HP:0002878)2.27033983
48Microvesicular hepatic steatosis (HP:0001414)2.23109362
49CNS demyelination (HP:0007305)2.20812588
50Palpitations (HP:0001962)2.19600777
51Hypoglycemic seizures (HP:0002173)2.17900993
52Hypothermia (HP:0002045)2.16133472
53Autoimmune hemolytic anemia (HP:0001890)2.13337114
54Encephalitis (HP:0002383)2.03538302
55Hemoptysis (HP:0002105)2.02795882
56Cerebral hypomyelination (HP:0006808)2.02254995
57Hypoglycemic coma (HP:0001325)2.00921676
58Amaurosis fugax (HP:0100576)2.00438362
59Abolished electroretinogram (ERG) (HP:0000550)1.99371728
60Sclerocornea (HP:0000647)1.99166023
61Emotional lability (HP:0000712)1.99003272
62Gangrene (HP:0100758)1.97442210
63Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.96571512
64Postaxial foot polydactyly (HP:0001830)1.95638338
65Cerebral hemorrhage (HP:0001342)1.94867302
66Cystic liver disease (HP:0006706)1.94750036
67Lethargy (HP:0001254)1.94613611
68Meningitis (HP:0001287)1.91936599
69Chronic diarrhea (HP:0002028)1.89078742
70Hyponatremia (HP:0002902)1.87326978
71Panhypogammaglobulinemia (HP:0003139)1.87128467
72Short tibia (HP:0005736)1.86309675
73Abnormality of DNA repair (HP:0003254)1.85983843
74Tetraplegia (HP:0002445)1.84245164
75Type I transferrin isoform profile (HP:0003642)1.84103257
76Thyroiditis (HP:0100646)1.83773042
77Stomatitis (HP:0010280)1.82135960
78Chest pain (HP:0100749)1.81848309
79Abnormality of renal resorption (HP:0011038)1.80386090
80Severe combined immunodeficiency (HP:0004430)1.79598046
81Hypoplasia of the thymus (HP:0000778)1.79242596
82Aplasia/Hypoplasia of the tongue (HP:0010295)1.79193205
83Glycosuria (HP:0003076)1.79025760
84Abnormality of urine glucose concentration (HP:0011016)1.79025760
85Carpal bone hypoplasia (HP:0001498)1.77840683
86Type 2 muscle fiber atrophy (HP:0003554)1.75629489
87Spastic paraparesis (HP:0002313)1.73384915
88Pancytopenia (HP:0001876)1.72069456
89Hyperinsulinemic hypoglycemia (HP:0000825)1.70118215
90Joint swelling (HP:0001386)1.69778379
91Male pseudohermaphroditism (HP:0000037)1.69725136
92Ketosis (HP:0001946)1.69104833
93Aplasia/Hypoplasia of the tibia (HP:0005772)1.69007919
94X-linked dominant inheritance (HP:0001423)1.68757118
95Constricted visual fields (HP:0001133)1.68119465
96Bifid tongue (HP:0010297)1.65881471
97Periodontitis (HP:0000704)1.61514220
98Nephronophthisis (HP:0000090)1.61136658
99Pendular nystagmus (HP:0012043)1.58836716
100Clitoromegaly (HP:0000057)1.57739340

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.73180625
2ZAK4.69677871
3BUB13.97679164
4EIF2AK33.82091608
5KDR3.51740238
6STK163.40127197
7MST43.38062887
8TRIM283.30274780
9BCKDK3.26487224
10ITK2.84396613
11EIF2AK12.44851799
12VRK22.33534844
13TLK12.13406355
14PIK3CA1.85642417
15VRK11.81480584
16PIK3CG1.77767738
17ADRBK21.74998512
18NUAK11.72206090
19TESK21.67631076
20MAP3K121.53529896
21JAK31.47285210
22NME11.40310297
23GRK11.35402227
24FRK1.26268574
25INSRR1.24360578
26WNK41.24169372
27BMPR1B1.18221073
28OXSR11.07966751
29MAP2K61.01240601
30PLK31.01136554
31SRPK10.98681864
32MAP3K50.96963674
33TEC0.95804078
34TIE10.87783581
35EIF2AK20.87219517
36SYK0.86346814
37LIMK10.86109459
38LCK0.80132109
39BMPR20.79664889
40ERBB30.77607633
41MYLK0.76778128
42GRK50.73331299
43PIM20.73281566
44GRK70.70542130
45DYRK20.68002318
46TESK10.67398285
47DAPK30.66097062
48CSNK1G30.64201540
49STK390.63914268
50PINK10.63777604
51MAP4K10.62825930
52TAOK30.58436178
53PRKCQ0.57916783
54CAMK2D0.56746818
55MAP2K70.55009342
56LYN0.53798775
57ZAP700.53506908
58DAPK10.52719572
59FES0.52123587
60TTK0.51365617
61PHKG10.51278569
62PHKG20.51278569
63TSSK60.48974756
64NTRK30.47771862
65MINK10.46600160
66BTK0.45642118
67CSNK1A10.45015124
68IGF1R0.44758766
69CDC70.44668238
70CSNK1G10.43495439
71CSNK1A1L0.42923235
72CSK0.40873488
73CSNK1G20.40013718
74PLK20.39240453
75JAK20.39064529
76WNK30.38780555
77PRKCA0.38563868
78PIM10.37555485
79PRKCE0.36178813
80AURKA0.36064223
81ROCK10.35700076
82FYN0.35037438
83PNCK0.34573662
84ALK0.32147188
85CSNK2A10.32134502
86MAP4K20.31560739
87RPS6KA50.31314904
88CAMK2G0.30417758
89CAMK2A0.30231985
90OBSCN0.28606989
91ATR0.28434695
92ADRBK10.27905954
93PAK10.25934120
94PLK10.25611011
95FGFR20.25516450
96PRKCH0.24467852
97WNK10.24420009
98FLT30.23575611
99PRKCB0.22733891
100CAMK1G0.22411019

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.51860943
2Allograft rejection_Homo sapiens_hsa053304.04570037
3Graft-versus-host disease_Homo sapiens_hsa053323.84314041
4Autoimmune thyroid disease_Homo sapiens_hsa053203.62367697
5Type I diabetes mellitus_Homo sapiens_hsa049403.47012640
6Protein export_Homo sapiens_hsa030603.22370114
7Oxidative phosphorylation_Homo sapiens_hsa001903.15647689
8Rheumatoid arthritis_Homo sapiens_hsa053232.93558756
9Primary immunodeficiency_Homo sapiens_hsa053402.76897967
10Parkinsons disease_Homo sapiens_hsa050122.69093024
11RNA polymerase_Homo sapiens_hsa030202.22673484
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.01124433
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.96258200
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.88273505
15Antigen processing and presentation_Homo sapiens_hsa046121.85962181
16Salmonella infection_Homo sapiens_hsa051321.77573367
17Hematopoietic cell lineage_Homo sapiens_hsa046401.69031907
18Alzheimers disease_Homo sapiens_hsa050101.52758689
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.47197307
20Huntingtons disease_Homo sapiens_hsa050161.43697510
21One carbon pool by folate_Homo sapiens_hsa006701.43415733
22Cardiac muscle contraction_Homo sapiens_hsa042601.38540010
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.38364424
24T cell receptor signaling pathway_Homo sapiens_hsa046601.27892389
25Nitrogen metabolism_Homo sapiens_hsa009101.27773835
26Mismatch repair_Homo sapiens_hsa034301.24181608
27Asthma_Homo sapiens_hsa053101.23655306
28Butanoate metabolism_Homo sapiens_hsa006501.23601635
29Homologous recombination_Homo sapiens_hsa034401.15798243
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.15740046
31Ribosome_Homo sapiens_hsa030101.07776268
32DNA replication_Homo sapiens_hsa030301.05485412
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.04146936
34Systemic lupus erythematosus_Homo sapiens_hsa053221.03048505
35Propanoate metabolism_Homo sapiens_hsa006401.01921561
36Peroxisome_Homo sapiens_hsa041461.01710035
37Viral myocarditis_Homo sapiens_hsa054160.99655333
38Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.99038204
39Fatty acid elongation_Homo sapiens_hsa000620.92619337
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.82000870
41Basal transcription factors_Homo sapiens_hsa030220.78951864
42Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.78443917
43Collecting duct acid secretion_Homo sapiens_hsa049660.76034916
44Measles_Homo sapiens_hsa051620.75666053
45Steroid biosynthesis_Homo sapiens_hsa001000.75442149
46Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73789916
47Pyrimidine metabolism_Homo sapiens_hsa002400.73170871
48Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.72982711
49Spliceosome_Homo sapiens_hsa030400.69779204
50Nucleotide excision repair_Homo sapiens_hsa034200.69675504
51Malaria_Homo sapiens_hsa051440.68232824
52Regulation of autophagy_Homo sapiens_hsa041400.66304266
53Fanconi anemia pathway_Homo sapiens_hsa034600.65506645
54Maturity onset diabetes of the young_Homo sapiens_hsa049500.63897800
55Purine metabolism_Homo sapiens_hsa002300.62580610
56Phototransduction_Homo sapiens_hsa047440.61940907
57RNA degradation_Homo sapiens_hsa030180.61195331
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59742162
59Epstein-Barr virus infection_Homo sapiens_hsa051690.57881277
60Tryptophan metabolism_Homo sapiens_hsa003800.57382585
61Fatty acid metabolism_Homo sapiens_hsa012120.53702291
62Caffeine metabolism_Homo sapiens_hsa002320.53145516
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52790047
64N-Glycan biosynthesis_Homo sapiens_hsa005100.52047071
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51280915
66Linoleic acid metabolism_Homo sapiens_hsa005910.51067401
67African trypanosomiasis_Homo sapiens_hsa051430.51027737
68Sulfur metabolism_Homo sapiens_hsa009200.50745387
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.47880456
70Folate biosynthesis_Homo sapiens_hsa007900.47759049
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47060286
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46541917
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45062999
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44358226
75Jak-STAT signaling pathway_Homo sapiens_hsa046300.44060311
76RNA transport_Homo sapiens_hsa030130.43293564
77Metabolic pathways_Homo sapiens_hsa011000.40328069
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39162927
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.38509042
80Olfactory transduction_Homo sapiens_hsa047400.37478470
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.37225236
82Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.35753464
83Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.35131451
84Retinol metabolism_Homo sapiens_hsa008300.34490315
85Fatty acid degradation_Homo sapiens_hsa000710.32929711
86Toll-like receptor signaling pathway_Homo sapiens_hsa046200.30819104
87Chemokine signaling pathway_Homo sapiens_hsa040620.27754012
88Mineral absorption_Homo sapiens_hsa049780.27446140
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.26195477
90Herpes simplex infection_Homo sapiens_hsa051680.22332262
91HTLV-I infection_Homo sapiens_hsa051660.21594610
92Alcoholism_Homo sapiens_hsa050340.18685525
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.18376261
94NF-kappa B signaling pathway_Homo sapiens_hsa040640.17967345
95Shigellosis_Homo sapiens_hsa051310.17397478
96Leishmaniasis_Homo sapiens_hsa051400.15978733
97Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.15895727
98Base excision repair_Homo sapiens_hsa034100.15482945
99Non-homologous end-joining_Homo sapiens_hsa034500.14763160
100Synaptic vesicle cycle_Homo sapiens_hsa047210.14249874

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