ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	axonemal dynein complex assembly (GO:0070286)	5.90235739
2	cilium movement (GO:0003341)	5.23997756
3	DNA deamination (GO:0045006)	5.20983773
4	epithelial cilium movement (GO:0003351)	5.15122311
5	positive regulation of calcium ion import (GO:0090280)	4.86185813
6	somite development (GO:0061053)	4.79120534
7	axoneme assembly (GO:0035082)	4.60511336
8	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.58788812
9	RNA destabilization (GO:0050779)	4.58100425
10	left/right pattern formation (GO:0060972)	4.53506376
11	aldehyde catabolic process (GO:0046185)	4.44222340
12	radial glial cell differentiation (GO:0060019)	4.27884663
13	rRNA methylation (GO:0031167)	4.26692419
14	phenylpropanoid metabolic process (GO:0009698)	4.25801017
15	cilium or flagellum-dependent cell motility (GO:0001539)	4.03029383
16	positive regulation of catecholamine secretion (GO:0033605)	4.00312253
17	regulation of cellular extravasation (GO:0002691)	3.99907404
18	rRNA modification (GO:0000154)	3.97189153
19	parturition (GO:0007567)	3.70295144
20	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	3.69772962
21	negative regulation of leukocyte migration (GO:0002686)	3.61572916
22	cytidine metabolic process (GO:0046087)	3.59248502
23	cytidine catabolic process (GO:0006216)	3.59248502
24	cytidine deamination (GO:0009972)	3.59248502
25	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO	3.56725813
26	regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)	3.56725813
27	protein neddylation (GO:0045116)	3.56168467
28	protein-cofactor linkage (GO:0018065)	3.52560441
29	positive regulation of monocyte chemotaxis (GO:0090026)	3.50981494
30	intraciliary transport (GO:0042073)	3.46725675
31	motile cilium assembly (GO:0044458)	3.46457870
32	response to gravity (GO:0009629)	3.44266824
33	protein polyglutamylation (GO:0018095)	3.39069051
34	peptidyl-arginine methylation (GO:0018216)	3.38825629
35	peptidyl-arginine N-methylation (GO:0035246)	3.38825629
36	regulation of monocyte differentiation (GO:0045655)	3.37078008
37	peptidyl-arginine omega-N-methylation (GO:0035247)	3.36990025
38	chaperone mediated protein folding requiring cofactor (GO:0051085)	3.34093964
39	protein K11-linked deubiquitination (GO:0035871)	3.32529470
40	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.31935308
41	retinal rod cell development (GO:0046548)	3.30943146
42	inner mitochondrial membrane organization (GO:0007007)	3.30831609
43	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.30190200
44	germ cell migration (GO:0008354)	3.19336286
45	auditory receptor cell differentiation (GO:0042491)	3.18714664
46	ubiquinone biosynthetic process (GO:0006744)	3.12139610
47	neurotransmitter catabolic process (GO:0042135)	3.11898982
48	positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:00357	3.09850725
49	regulation of gonadotropin secretion (GO:0032276)	3.04454032
50	protein prenylation (GO:0018342)	3.00635547
51	prenylation (GO:0097354)	3.00635547
52	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO	2.92825677
53	positive thymic T cell selection (GO:0045059)	2.90698400
54	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.89366515
55	regulation of glucocorticoid secretion (GO:2000849)	2.87919499
56	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.86832485
57	Arp2/3 complex-mediated actin nucleation (GO:0034314)	2.84834615
58	positive regulation of digestive system process (GO:0060456)	2.84524018
59	cardiolipin metabolic process (GO:0032048)	2.80649925
60	positive regulation of mRNA 3-end processing (GO:0031442)	2.80472437
61	cilium morphogenesis (GO:0060271)	2.80468170
62	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)	2.79424374
63	regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)	2.79424374
64	neuron fate determination (GO:0048664)	2.77869274
65	sleep (GO:0030431)	2.77315341
66	positive regulation of mitochondrial fission (GO:0090141)	2.76484406
67	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.74222203
68	metallo-sulfur cluster assembly (GO:0031163)	2.74217879
69	iron-sulfur cluster assembly (GO:0016226)	2.74217879
70	photoreceptor cell maintenance (GO:0045494)	2.71361360
71	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.70960125
72	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.69343315
73	peroxisome fission (GO:0016559)	2.68794248
74	cellular response to dexamethasone stimulus (GO:0071549)	2.68627178
75	axon ensheathment in central nervous system (GO:0032291)	2.68486591
76	central nervous system myelination (GO:0022010)	2.68486591
77	respiratory chain complex IV assembly (GO:0008535)	2.67437251
78	photoreceptor cell development (GO:0042461)	2.66816575
79	photoreceptor cell differentiation (GO:0046530)	2.65439652
80	eye photoreceptor cell differentiation (GO:0001754)	2.65439652
81	response to muramyl dipeptide (GO:0032495)	2.64553992
82	cilium organization (GO:0044782)	2.63905409
83	seminiferous tubule development (GO:0072520)	2.63413328
84	ubiquinone metabolic process (GO:0006743)	2.62850029
85	primary alcohol catabolic process (GO:0034310)	2.62392352
86	regulation of calcium ion import (GO:0090279)	2.61697783
87	positive regulation of steroid hormone secretion (GO:2000833)	2.61490472
88	positive regulation of mRNA catabolic process (GO:0061014)	2.61221254
89	branched-chain amino acid catabolic process (GO:0009083)	2.60610684
90	quinone biosynthetic process (GO:1901663)	2.59274958
91	adenosine metabolic process (GO:0046085)	2.58860005
92	regulation of cilium movement (GO:0003352)	2.58230397
93	glucocorticoid biosynthetic process (GO:0006704)	2.56403119
94	histone arginine methylation (GO:0034969)	2.54884106
95	positive regulation of cholesterol efflux (GO:0010875)	2.53381934
96	peptidyl-histidine modification (GO:0018202)	2.52863240
97	cilium assembly (GO:0042384)	2.52378901
98	nonmotile primary cilium assembly (GO:0035058)	2.52181380
99	regulation of germinal center formation (GO:0002634)	2.51911318
100	positive regulation of T cell migration (GO:2000406)	2.50769688

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	5.43916283
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.63984892
3	IRF8_22096565_ChIP-ChIP_GC-B_Human	4.03470215
4	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.94090365
5	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.12086163
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.97783736
7	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.89730941
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.67630871
9	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.65274934
10	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.58355854
11	IRF1_19129219_ChIP-ChIP_H3396_Human	2.51972898
12	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.39109623
13	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.38996524
14	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.38848759
15	ZNF274_21170338_ChIP-Seq_K562_Hela	2.34935320
16	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.28212641
17	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	2.26058765
18	VDR_23849224_ChIP-Seq_CD4+_Human	2.15524106
19	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.02762918
20	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.01159513
21	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.88464917
22	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.80705987
23	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.79763921
24	FOXP3_21729870_ChIP-Seq_TREG_Human	1.66368789
25	IGF1R_20145208_ChIP-Seq_DFB_Human	1.58975958
26	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.58793581
27	AR_20517297_ChIP-Seq_VCAP_Human	1.56715556
28	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.52362080
29	GATA3_26560356_Chip-Seq_TH2_Human	1.51816437
30	GATA3_27048872_Chip-Seq_THYMUS_Human	1.49325448
31	CIITA_25753668_ChIP-Seq_RAJI_Human	1.44906741
32	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.36802868
33	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.36721845
34	MYC_18940864_ChIP-ChIP_HL60_Human	1.33907797
35	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.32963871
36	VDR_22108803_ChIP-Seq_LS180_Human	1.28695502
37	GATA1_22025678_ChIP-Seq_K562_Human	1.26977360
38	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.26270222
39	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.25543092
40	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.23755129
41	EWS_26573619_Chip-Seq_HEK293_Human	1.22976364
42	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.22716741
43	ELK1_19687146_ChIP-ChIP_HELA_Human	1.20041525
44	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.19529504
45	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.19529504
46	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.15576652
47	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.14545936
48	MYB_26560356_Chip-Seq_TH2_Human	1.14283833
49	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.13821180
50	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.12794644
51	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.11877142
52	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.11227730
53	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.10493009
54	GABP_19822575_ChIP-Seq_HepG2_Human	1.08829998
55	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.07879945
56	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.07792704
57	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.07751568
58	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.06746075
59	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.06576657
60	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.06452487
61	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.04604552
62	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.04568755
63	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.04485224
64	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.03772377
65	ER_23166858_ChIP-Seq_MCF-7_Human	1.02878400
66	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.01669005
67	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.00883535
68	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.00292985
69	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.99558198
70	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	0.99375206
71	BCL6_27268052_Chip-Seq_Bcells_Human	0.99075585
72	PHF8_20622853_ChIP-Seq_HELA_Human	0.97784691
73	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.97081224
74	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	0.96947908
75	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.96657399
76	NCOR_22424771_ChIP-Seq_293T_Human	0.95119850
77	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.94785872
78	NANOG_20526341_ChIP-Seq_ESCs_Human	0.94671390
79	TTF2_22483619_ChIP-Seq_HELA_Human	0.94631145
80	SOX2_19829295_ChIP-Seq_ESCs_Human	0.93757778
81	NANOG_19829295_ChIP-Seq_ESCs_Human	0.93757778
82	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.93264906
83	SMRT_27268052_Chip-Seq_Bcells_Human	0.92089997
84	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	0.91680283
85	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.91614141
86	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.91347731
87	STAT4_19710469_ChIP-ChIP_TH1__Mouse	0.89494391
88	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.89341699
89	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.89262390
90	CBP_20019798_ChIP-Seq_JUKART_Human	0.89262390
91	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.88790622
92	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.88604368
93	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.87427958
94	CEBPB_22108803_ChIP-Seq_LS180_Human	0.85847139
95	SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human	0.85792012
96	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.85741211
97	BCAT_22108803_ChIP-Seq_LS180_Human	0.85574961
98	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.85409639
99	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.84944748
100	XRN2_22483619_ChIP-Seq_HELA_Human	0.84703806

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009278_abnormal_bone_marrow	4.49457419
2	MP0002653_abnormal_ependyma_morphology	3.16148901
3	MP0004147_increased_porphyrin_level	2.83839150
4	MP0005646_abnormal_pituitary_gland	2.78557483
5	MP0001545_abnormal_hematopoietic_system	2.67828418
6	MP0005397_hematopoietic_system_phenotyp	2.67828418
7	MP0003724_increased_susceptibility_to	2.60763011
8	MP0008875_abnormal_xenobiotic_pharmacok	2.41612676
9	MP0003718_maternal_effect	2.19296932
10	MP0005551_abnormal_eye_electrophysiolog	2.04024003
11	MP0002282_abnormal_trachea_morphology	2.02813085
12	MP0001919_abnormal_reproductive_system	2.01127247
13	MP0008789_abnormal_olfactory_epithelium	2.00992417
14	MP0009333_abnormal_splenocyte_physiolog	1.98556834
15	MP0001501_abnormal_sleep_pattern	1.90405561
16	MP0005075_abnormal_melanosome_morpholog	1.88195918
17	MP0002638_abnormal_pupillary_reflex	1.87215965
18	MP0002938_white_spotting	1.84005663
19	MP0001984_abnormal_olfaction	1.81139482
20	MP0001986_abnormal_taste_sensitivity	1.74752575
21	MP0002837_dystrophic_cardiac_calcinosis	1.73102839
22	MP0006036_abnormal_mitochondrial_physio	1.71952988
23	MP0004782_abnormal_surfactant_physiolog	1.71314158
24	MP0006072_abnormal_retinal_apoptosis	1.68374448
25	MP0005389_reproductive_system_phenotype	1.68236919
26	MP0000372_irregular_coat_pigmentation	1.68113300
27	MP0005503_abnormal_tendon_morphology	1.66264734
28	MP0003763_abnormal_thymus_physiology	1.63918162
29	MP0002132_abnormal_respiratory_system	1.62739677
30	MP0004133_heterotaxia	1.61673796
31	MP0003136_yellow_coat_color	1.56470743
32	MP0005000_abnormal_immune_tolerance	1.56401831
33	MP0005671_abnormal_response_to	1.48259846
34	MP0000689_abnormal_spleen_morphology	1.33994209
35	MP0002148_abnormal_hypersensitivity_rea	1.33663476
36	MP0003656_abnormal_erythrocyte_physiolo	1.32340792
37	MP0002933_joint_inflammation	1.32060181
38	MP0005645_abnormal_hypothalamus_physiol	1.29003338
39	MP0002405_respiratory_system_inflammati	1.26197612
40	MP0001727_abnormal_embryo_implantation	1.25466327
41	MP0004858_abnormal_nervous_system	1.22384718
42	MP0004043_abnormal_pH_regulation	1.19666173
43	MP0001764_abnormal_homeostasis	1.17571981
44	MP0001851_eye_inflammation	1.17141631
45	MP0002249_abnormal_larynx_morphology	1.16847241
46	MP0002723_abnormal_immune_serum	1.16552152
47	MP0003186_abnormal_redox_activity	1.16142449
48	MP0005499_abnormal_olfactory_system	1.12649258
49	MP0005394_taste/olfaction_phenotype	1.12649258
50	MP0001533_abnormal_skeleton_physiology	1.12227705
51	MP0003943_abnormal_hepatobiliary_system	1.12099026
52	MP0001800_abnormal_humoral_immune	1.08516731
53	MP0000639_abnormal_adrenal_gland	1.08094258
54	MP0005390_skeleton_phenotype	1.06613796
55	MP0001835_abnormal_antigen_presentation	1.05438714
56	MP0002095_abnormal_skin_pigmentation	1.05417179
57	MP0009785_altered_susceptibility_to	1.04830849
58	MP0002722_abnormal_immune_system	1.04513562
59	MP0002420_abnormal_adaptive_immunity	1.01497646
60	MP0005253_abnormal_eye_physiology	1.00885151
61	MP0000685_abnormal_immune_system	1.00530214
62	MP0001819_abnormal_immune_cell	0.98262601
63	MP0001853_heart_inflammation	0.97895359
64	MP0002452_abnormal_antigen_presenting	0.96962028
65	MP0002166_altered_tumor_susceptibility	0.96487400
66	MP0001542_abnormal_bone_strength	0.96069115
67	MP0004134_abnormal_chest_morphology	0.94921961
68	MP0003121_genomic_imprinting	0.93070066
69	MP0008995_early_reproductive_senescence	0.92922407
70	MP0003806_abnormal_nucleotide_metabolis	0.92650965
71	MP0002876_abnormal_thyroid_physiology	0.92622289
72	MP0003866_abnormal_defecation	0.91761952
73	MP0005220_abnormal_exocrine_pancreas	0.90387980
74	MP0005410_abnormal_fertilization	0.86500123
75	MP0003787_abnormal_imprinting	0.85206135
76	MP0005084_abnormal_gallbladder_morpholo	0.84579068
77	MP0002233_abnormal_nose_morphology	0.84573724
78	MP0008007_abnormal_cellular_replicative	0.83830205
79	MP0001293_anophthalmia	0.83282736
80	MP0006276_abnormal_autonomic_nervous	0.82239330
81	MP0003638_abnormal_response/metabolism_	0.81788209
82	MP0000703_abnormal_thymus_morphology	0.81678988
83	MP0003122_maternal_imprinting	0.79850946
84	MP0002108_abnormal_muscle_morphology	0.79706211
85	MP0008260_abnormal_autophagy	0.79503679
86	MP0005195_abnormal_posterior_eye	0.79454143
87	MP0005395_other_phenotype	0.79374111
88	MP0004808_abnormal_hematopoietic_stem	0.78684022
89	MP0005025_abnormal_response_to	0.78099451
90	MP0002419_abnormal_innate_immunity	0.78081596
91	MP0002160_abnormal_reproductive_system	0.78008801
92	MP0002398_abnormal_bone_marrow	0.77943144
93	MP0005508_abnormal_skeleton_morphology	0.76906682
94	MP0008469_abnormal_protein_level	0.75839845
95	MP0003786_premature_aging	0.74865205
96	MP0000716_abnormal_immune_system	0.73898746
97	MP0002277_abnormal_respiratory_mucosa	0.72294918
98	MP0010155_abnormal_intestine_physiology	0.72048255
99	MP0001324_abnormal_eye_pigmentation	0.71946651
100	MP0005164_abnormal_response_to	0.71366384

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	6.22505584
2	Rhinitis (HP:0012384)	6.06422806
3	Abnormal respiratory motile cilium physiology (HP:0012261)	5.19293675
4	Tubulointerstitial nephritis (HP:0001970)	5.18842662
5	Abnormal ciliary motility (HP:0012262)	4.84997703
6	Abnormal respiratory motile cilium morphology (HP:0005938)	4.72011034
7	Abnormal respiratory epithelium morphology (HP:0012253)	4.72011034
8	Absent/shortened dynein arms (HP:0200106)	4.56445108
9	Dynein arm defect of respiratory motile cilia (HP:0012255)	4.56445108
10	True hermaphroditism (HP:0010459)	4.09601713
11	Elevated erythrocyte sedimentation rate (HP:0003565)	3.85227731
12	Congenital stationary night blindness (HP:0007642)	3.57665582
13	Renal cortical cysts (HP:0000803)	3.57147790
14	Chronic bronchitis (HP:0004469)	3.52329243
15	Nephronophthisis (HP:0000090)	3.51157345
16	Medial flaring of the eyebrow (HP:0010747)	3.45072224
17	Pancreatic fibrosis (HP:0100732)	3.25563873
18	Nephrogenic diabetes insipidus (HP:0009806)	3.18443514
19	Bronchiectasis (HP:0002110)	3.17411801
20	Abnormality of the renal medulla (HP:0100957)	3.09692834
21	Enlarged kidneys (HP:0000105)	3.09583221
22	Abolished electroretinogram (ERG) (HP:0000550)	3.05743036
23	Pancreatic cysts (HP:0001737)	2.90033371
24	Congenital primary aphakia (HP:0007707)	2.87962299
25	Abnormality of the renal cortex (HP:0011035)	2.84900374
26	Asplenia (HP:0001746)	2.77579168
27	Gait imbalance (HP:0002141)	2.73732170
28	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.71094718
29	Dyschromatopsia (HP:0007641)	2.69588748
30	Hepatic necrosis (HP:0002605)	2.66919607
31	Molar tooth sign on MRI (HP:0002419)	2.65008571
32	Abnormality of midbrain morphology (HP:0002418)	2.65008571
33	Tubulointerstitial abnormality (HP:0001969)	2.62278298
34	Hypoglycemic seizures (HP:0002173)	2.55545430
35	Attenuation of retinal blood vessels (HP:0007843)	2.54872843
36	Neuroendocrine neoplasm (HP:0100634)	2.53993311
37	Congenital hepatic fibrosis (HP:0002612)	2.51929497
38	Abnormal rod and cone electroretinograms (HP:0008323)	2.49237110
39	Mesangial abnormality (HP:0001966)	2.48636001
40	Cystic liver disease (HP:0006706)	2.48116625
41	Hepatocellular necrosis (HP:0001404)	2.44390233
42	Chronic otitis media (HP:0000389)	2.42046927
43	Abnormality of macular pigmentation (HP:0008002)	2.40940784
44	Premature loss of primary teeth (HP:0006323)	2.38208829
45	Tubular atrophy (HP:0000092)	2.34564982
46	Anhidrosis (HP:0000970)	2.27883793
47	Gonadal dysgenesis (HP:0000133)	2.25343513
48	Median cleft lip (HP:0000161)	2.23695710
49	Recurrent sinusitis (HP:0011108)	2.23382929
50	Chronic sinusitis (HP:0011109)	2.20843722
51	Hypoglycemic coma (HP:0001325)	2.20351640
52	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.17907718
53	Prostate neoplasm (HP:0100787)	2.16136516
54	Occipital encephalocele (HP:0002085)	2.15612497
55	Male pseudohermaphroditism (HP:0000037)	2.15445852
56	Polyphagia (HP:0002591)	2.14551352
57	Decreased central vision (HP:0007663)	2.07487375
58	Anencephaly (HP:0002323)	2.04510822
59	Broad foot (HP:0001769)	2.03202814
60	Osteomalacia (HP:0002749)	2.02972726
61	Infertility (HP:0000789)	1.97825725
62	Abnormal drinking behavior (HP:0030082)	1.97756329
63	Polydipsia (HP:0001959)	1.97756329
64	Type I transferrin isoform profile (HP:0003642)	1.96349454
65	Poor coordination (HP:0002370)	1.95942912
66	Progressive inability to walk (HP:0002505)	1.94715395
67	Sclerocornea (HP:0000647)	1.94334018
68	Neoplasm of the heart (HP:0100544)	1.93930814
69	Mitochondrial inheritance (HP:0001427)	1.91109037
70	Abnormality of the prostate (HP:0008775)	1.90687356
71	Hyperinsulinemic hypoglycemia (HP:0000825)	1.90665082
72	Nasal polyposis (HP:0100582)	1.89897661
73	Postaxial foot polydactyly (HP:0001830)	1.89873734
74	Papilledema (HP:0001085)	1.89153189
75	Focal motor seizures (HP:0011153)	1.88858168
76	Testicular neoplasm (HP:0010788)	1.87776541
77	Growth hormone deficiency (HP:0000824)	1.85314904
78	Abnormality of the costochondral junction (HP:0000919)	1.83606548
79	Adrenal hypoplasia (HP:0000835)	1.83298549
80	Abnormality of the nasal septum (HP:0000419)	1.82943904
81	Stage 5 chronic kidney disease (HP:0003774)	1.82600828
82	Increased CSF lactate (HP:0002490)	1.82569541
83	Growth hormone excess (HP:0000845)	1.81360368
84	Dicarboxylic aciduria (HP:0003215)	1.79711192
85	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.79711192
86	Abnormality of the vocal cords (HP:0008777)	1.78810212
87	Bilateral microphthalmos (HP:0007633)	1.78569358
88	Primary adrenal insufficiency (HP:0008207)	1.78429565
89	Autoimmune hemolytic anemia (HP:0001890)	1.75110884
90	3-Methylglutaconic aciduria (HP:0003535)	1.74893811
91	Genital tract atresia (HP:0001827)	1.72506471
92	Failure to thrive in infancy (HP:0001531)	1.72248641
93	Bronchitis (HP:0012387)	1.70458243
94	Vaginal atresia (HP:0000148)	1.68280281
95	Optic disc pallor (HP:0000543)	1.65751374
96	Oligohydramnios (HP:0001562)	1.63072827
97	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.63006945
98	Optic nerve coloboma (HP:0000588)	1.62382586
99	Bell-shaped thorax (HP:0001591)	1.61777918
100	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.60434037

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	4.40236935
2	MAPK15	4.16888939
3	NUAK1	3.85140900
4	MAP2K2	3.73806462
5	BRSK2	3.42555695
6	MST4	2.93508039
7	KIT	2.48269255
8	TNK2	2.31391435
9	ZAK	2.15453611
10	TLK1	2.14240228
11	VRK2	2.08443154
12	IKBKB	2.04950383
13	MAP3K14	2.04947829
14	ERN1	2.03216878
15	TBK1	1.99265108
16	IKBKE	1.95805520
17	VRK1	1.92666325
18	MAP4K2	1.87809335
19	MKNK1	1.86799755
20	BCKDK	1.83560002
21	MAPKAPK5	1.65259495
22	EIF2AK2	1.47665784
23	FES	1.44136043
24	PRKCQ	1.42914847
25	MARK3	1.41109552
26	WNK4	1.39326309
27	TESK2	1.29812212
28	RPS6KA5	1.26250755
29	TIE1	1.26187523
30	BMPR1B	1.23641942
31	TSSK6	1.21240342
32	TAF1	1.16236066
33	TEC	1.15789082
34	BRSK1	1.13444966
35	GRK1	1.10379671
36	KDR	1.09096066
37	GRK7	1.07304432
38	CASK	1.06538161
39	PASK	1.04372030
40	SCYL2	0.98354671
41	TAOK3	0.95378920
42	NLK	0.91421679
43	CHUK	0.86164122
44	BCR	0.84316361
45	DYRK2	0.78931105
46	MAPK4	0.78163835
47	DYRK1A	0.77187418
48	PKN1	0.76997307
49	CDK3	0.75644259
50	ADRBK2	0.71758596
51	LCK	0.71744788
52	MAP4K1	0.68347922
53	JAK1	0.68155224
54	NME2	0.67294221
55	STK11	0.64554331
56	BTK	0.63020374
57	MAPK7	0.62194798
58	MAP3K7	0.61989940
59	PIK3CA	0.61757996
60	LYN	0.60020961
61	PLK3	0.59661739
62	BMPR2	0.57674245
63	ITK	0.57237860
64	ADRBK1	0.56365805
65	STK39	0.56051558
66	MAP2K1	0.55948503
67	WNK3	0.55142479
68	TGFBR1	0.52949482
69	RPS6KA1	0.51231379
70	CSK	0.50545733
71	GRK5	0.49249419
72	FRK	0.48064059
73	MAPK3	0.47708401
74	DMPK	0.47065042
75	SYK	0.46348953
76	MAPKAPK2	0.45563693
77	MAP2K7	0.44900561
78	STK16	0.41718276
79	DYRK1B	0.41449739
80	MAP3K12	0.40701172
81	EPHA3	0.38084952
82	CAMK2D	0.36588120
83	PLK4	0.35198288
84	RPS6KA6	0.34983605
85	GRK6	0.34978537
86	MOS	0.34431211
87	MAP3K11	0.34345703
88	TGFBR2	0.33982182
89	CSNK1G1	0.33778778
90	CSF1R	0.33282214
91	FYN	0.32630921
92	ILK	0.31727569
93	PTK2B	0.31657392
94	IGF1R	0.31199942
95	CDK8	0.31131873
96	PAK6	0.30910975
97	PRKACA	0.29269022
98	CDK19	0.28891486
99	PRKAA2	0.28501340
100	MAPK11	0.27893753

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Cyanoamino acid metabolism_Homo sapiens_hsa00460	3.35408335
2	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	3.08737513
3	Fatty acid elongation_Homo sapiens_hsa00062	2.77517416
4	Graft-versus-host disease_Homo sapiens_hsa05332	2.67640714
5	Primary immunodeficiency_Homo sapiens_hsa05340	2.17367273
6	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.12108819
7	Antigen processing and presentation_Homo sapiens_hsa04612	2.09455671
8	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.04510955
9	Butanoate metabolism_Homo sapiens_hsa00650	2.04172566
10	Sulfur relay system_Homo sapiens_hsa04122	2.02184305
11	Folate biosynthesis_Homo sapiens_hsa00790	1.96622386
12	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.94830047
13	Phototransduction_Homo sapiens_hsa04744	1.91240910
14	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.89978274
15	Asthma_Homo sapiens_hsa05310	1.83956461
16	Allograft rejection_Homo sapiens_hsa05330	1.83097526
17	Peroxisome_Homo sapiens_hsa04146	1.82843798
18	Chemical carcinogenesis_Homo sapiens_hsa05204	1.78214272
19	Proteasome_Homo sapiens_hsa03050	1.72730635
20	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.69690150
21	Type I diabetes mellitus_Homo sapiens_hsa04940	1.68471265
22	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.67575922
23	Propanoate metabolism_Homo sapiens_hsa00640	1.63074126
24	RNA degradation_Homo sapiens_hsa03018	1.58559963
25	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.51657776
26	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.50260432
27	Rheumatoid arthritis_Homo sapiens_hsa05323	1.45851332
28	Protein export_Homo sapiens_hsa03060	1.45733654
29	Linoleic acid metabolism_Homo sapiens_hsa00591	1.42049666
30	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.39963105
31	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.37674877
32	Tyrosine metabolism_Homo sapiens_hsa00350	1.35468029
33	Tryptophan metabolism_Homo sapiens_hsa00380	1.34904354
34	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.30787419
35	Basal transcription factors_Homo sapiens_hsa03022	1.29607278
36	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.28802379
37	beta-Alanine metabolism_Homo sapiens_hsa00410	1.27372763
38	Fatty acid degradation_Homo sapiens_hsa00071	1.24911255
39	Fanconi anemia pathway_Homo sapiens_hsa03460	1.22730665
40	Parkinsons disease_Homo sapiens_hsa05012	1.22391132
41	Glutathione metabolism_Homo sapiens_hsa00480	1.19967698
42	Regulation of autophagy_Homo sapiens_hsa04140	1.18627347
43	Oxidative phosphorylation_Homo sapiens_hsa00190	1.12405607
44	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.12218767
45	One carbon pool by folate_Homo sapiens_hsa00670	1.10626741
46	Retinol metabolism_Homo sapiens_hsa00830	1.07351909
47	Nucleotide excision repair_Homo sapiens_hsa03420	1.06185469
48	Fatty acid metabolism_Homo sapiens_hsa01212	1.04719303
49	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.04417559
50	Legionellosis_Homo sapiens_hsa05134	1.02455746
51	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.01986190
52	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.99643290
53	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.97216275
54	Caffeine metabolism_Homo sapiens_hsa00232	0.96323575
55	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.93790658
56	Huntingtons disease_Homo sapiens_hsa05016	0.93606462
57	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.91955737
58	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.90260311
59	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.88448004
60	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.87567215
61	Viral myocarditis_Homo sapiens_hsa05416	0.86237042
62	Ribosome_Homo sapiens_hsa03010	0.82465192
63	Nitrogen metabolism_Homo sapiens_hsa00910	0.77887239
64	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.74696550
65	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.73595456
66	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.73437279
67	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.71507784
68	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.68897003
69	Homologous recombination_Homo sapiens_hsa03440	0.66804147
70	Phenylalanine metabolism_Homo sapiens_hsa00360	0.66278267
71	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.65528147
72	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.63517546
73	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.62900385
74	Leishmaniasis_Homo sapiens_hsa05140	0.62310725
75	Olfactory transduction_Homo sapiens_hsa04740	0.61200627
76	Herpes simplex infection_Homo sapiens_hsa05168	0.60831222
77	Steroid biosynthesis_Homo sapiens_hsa00100	0.59331034
78	Glycerolipid metabolism_Homo sapiens_hsa00561	0.57520295
79	ABC transporters_Homo sapiens_hsa02010	0.56974762
80	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.56417261
81	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.53892959
82	Basal cell carcinoma_Homo sapiens_hsa05217	0.53477557
83	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.52263068
84	Metabolic pathways_Homo sapiens_hsa01100	0.48626742
85	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.47765131
86	Base excision repair_Homo sapiens_hsa03410	0.45618341
87	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.44934814
88	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.43504209
89	Carbon metabolism_Homo sapiens_hsa01200	0.43268103
90	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.42699319
91	Alzheimers disease_Homo sapiens_hsa05010	0.42225819
92	Histidine metabolism_Homo sapiens_hsa00340	0.39943970
93	Spliceosome_Homo sapiens_hsa03040	0.39447853
94	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.38022500
95	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.36497741
96	Selenocompound metabolism_Homo sapiens_hsa00450	0.35623209
97	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.32659014
98	Pyruvate metabolism_Homo sapiens_hsa00620	0.32400311
99	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.30208563
100	Measles_Homo sapiens_hsa05162	0.29502065

SNRPCP3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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