SNRPCP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of interleukin-12 biosynthetic process (GO:0045075)9.84929529
2regulation of vitamin D biosynthetic process (GO:0060556)9.37038235
3positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)9.36757383
4negative regulation of metanephros development (GO:0072217)9.20002804
5negative regulation of interleukin-17 production (GO:0032700)8.08123010
6regulation of isotype switching to IgG isotypes (GO:0048302)8.04848752
7regulation of vitamin metabolic process (GO:0030656)7.70077206
8regulation of MHC class II biosynthetic process (GO:0045346)7.65130088
9positive regulation of chemokine biosynthetic process (GO:0045080)7.62190284
10negative regulation of neurological system process (GO:0031645)7.28463310
11regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)7.00616023
12positive regulation of isotype switching (GO:0045830)6.79737236
13positive regulation of DNA recombination (GO:0045911)6.16248559
14positive regulation of osteoclast differentiation (GO:0045672)5.89870327
15positive regulation of muscle cell apoptotic process (GO:0010661)5.80391980
16negative regulation of growth of symbiont in host (GO:0044130)5.72713144
17negative regulation of growth of symbiont involved in interaction with host (GO:0044146)5.72713144
18modulation of growth of symbiont involved in interaction with host (GO:0044144)5.72713144
19regulation of growth of symbiont in host (GO:0044126)5.72713144
20regulation of chemokine biosynthetic process (GO:0045073)5.65773864
21regulation of interleukin-6 biosynthetic process (GO:0045408)5.56199931
22positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)5.55211566
23positive regulation of macrophage derived foam cell differentiation (GO:0010744)5.42824053
24positive regulation of steroid biosynthetic process (GO:0010893)5.35100570
25regulation of smooth muscle cell apoptotic process (GO:0034391)5.29529049
26regulation of nephron tubule epithelial cell differentiation (GO:0072182)5.24313698
27negative regulation of kidney development (GO:0090185)5.23966170
28alpha-beta T cell differentiation involved in immune response (GO:0002293)4.98833634
29alpha-beta T cell activation involved in immune response (GO:0002287)4.98833634
30T cell differentiation involved in immune response (GO:0002292)4.98833634
31positive regulation of interleukin-1 beta secretion (GO:0050718)4.96222860
32myeloid dendritic cell differentiation (GO:0043011)4.91696352
33defense response to protozoan (GO:0042832)4.86141064
34regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)4.82143106
35positive regulation of monooxygenase activity (GO:0032770)4.79563108
36positive regulation of membrane protein ectodomain proteolysis (GO:0051044)4.75691759
37regulation of epithelial cell differentiation involved in kidney development (GO:2000696)4.74367776
38positive regulation of interleukin-1 secretion (GO:0050716)4.66104919
39leukocyte apoptotic process (GO:0071887)4.61784855
40positive regulation of organelle assembly (GO:1902117)4.59914316
41regulation of interleukin-1 beta secretion (GO:0050706)4.56118487
42regulation of interleukin-17 production (GO:0032660)4.35288519
43myeloid dendritic cell activation (GO:0001773)4.33134036
44regulation of isotype switching (GO:0045191)4.32788141
45positive regulation of B cell mediated immunity (GO:0002714)4.28959425
46positive regulation of immunoglobulin mediated immune response (GO:0002891)4.28959425
47regulation of cytokine production involved in inflammatory response (GO:1900015)4.22995532
48positive regulation of interleukin-12 production (GO:0032735)4.06847352
49regulation of interleukin-1 secretion (GO:0050704)4.00528262
50positive regulation of alcohol biosynthetic process (GO:1902932)3.97451783
51regulation of membrane protein ectodomain proteolysis (GO:0051043)3.95988988
52response to protozoan (GO:0001562)3.94246933
53positive regulation of phosphatase activity (GO:0010922)3.82342765
54water-soluble vitamin biosynthetic process (GO:0042364)3.74370863
55somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.72552074
56somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.72552074
57isotype switching (GO:0045190)3.72552074
58regulation of metanephros development (GO:0072215)3.71248655
59positive regulation of interleukin-1 beta production (GO:0032731)3.68427326
60positive regulation of immunoglobulin production (GO:0002639)3.62828285
61positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)3.59463510
62regulation of response to interferon-gamma (GO:0060330)3.51537674
63regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.43467095
64regulation of centriole replication (GO:0046599)3.42753929
65protein import into nucleus, translocation (GO:0000060)3.42444068
66regulation of myelination (GO:0031641)3.40206917
67response to pheromone (GO:0019236)3.37766075
68maturation of 5.8S rRNA (GO:0000460)3.31388996
69positive regulation of interleukin-1 production (GO:0032732)3.24116622
70positive regulation of JAK-STAT cascade (GO:0046427)3.16662773
71alpha-beta T cell differentiation (GO:0046632)3.14178834
72cullin deneddylation (GO:0010388)3.14029515
73regulation of immunoglobulin production (GO:0002637)3.09228044
74regulation of the force of heart contraction (GO:0002026)3.06678707
75ether lipid metabolic process (GO:0046485)3.02668631
76regulation of tyrosine phosphorylation of STAT protein (GO:0042509)2.98516501
77DNA deamination (GO:0045006)2.95721829
78dendritic cell differentiation (GO:0097028)2.94165721
79protein deneddylation (GO:0000338)2.92246579
80regulation of immunoglobulin mediated immune response (GO:0002889)2.90396179
81positive regulation of myeloid leukocyte differentiation (GO:0002763)2.84623942
82positive regulation of steroid metabolic process (GO:0045940)2.84567112
83regulation of B cell mediated immunity (GO:0002712)2.81695421
84regulation of regulatory T cell differentiation (GO:0045589)2.81159469
85somatic recombination of immunoglobulin gene segments (GO:0016447)2.80445604
86regulation of cellular amino acid metabolic process (GO:0006521)2.75320619
87regulation of macrophage derived foam cell differentiation (GO:0010743)2.73651762
88regulation of interleukin-12 production (GO:0032655)2.68517860
89negative regulation of smooth muscle cell proliferation (GO:0048662)2.67838887
90positive regulation of oxidoreductase activity (GO:0051353)2.67757087
91alpha-beta T cell activation (GO:0046631)2.66802440
92cornea development in camera-type eye (GO:0061303)2.64078607
93negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.61188491
94retinal cone cell development (GO:0046549)2.57011299
95aldehyde catabolic process (GO:0046185)2.54527261
96positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)12.2272594
97regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)12.2272594
98regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:000333911.5098516
99regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)10.0055645
100regulation of podosome assembly (GO:0071801)10.0009095

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.03199113
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.39744047
3FLI1_27457419_Chip-Seq_LIVER_Mouse4.01093832
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.75827292
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.47019617
6PCGF2_27294783_Chip-Seq_ESCs_Mouse3.44480944
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.44160169
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.00613402
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.98418025
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.90806038
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.70168579
12PCGF2_27294783_Chip-Seq_NPCs_Mouse2.65834759
13SUZ12_27294783_Chip-Seq_NPCs_Mouse2.37053770
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.35971667
15ELK1_19687146_ChIP-ChIP_HELA_Human2.19420943
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.13445171
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.12000792
18IRF1_19129219_ChIP-ChIP_H3396_Human2.10819811
19NFE2_27457419_Chip-Seq_LIVER_Mouse2.08510363
20VDR_22108803_ChIP-Seq_LS180_Human2.08496498
21ZNF274_21170338_ChIP-Seq_K562_Hela2.05578571
22EZH2_27294783_Chip-Seq_NPCs_Mouse1.96745616
23VDR_23849224_ChIP-Seq_CD4+_Human1.91634906
24IGF1R_20145208_ChIP-Seq_DFB_Human1.89795959
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.85766625
26ETS1_20019798_ChIP-Seq_JURKAT_Human1.81014376
27POU3F2_20337985_ChIP-ChIP_501MEL_Human1.75320952
28GATA1_26923725_Chip-Seq_HPCs_Mouse1.74764778
29CREB1_15753290_ChIP-ChIP_HEK293T_Human1.67844654
30JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.62665318
31GBX2_23144817_ChIP-Seq_PC3_Human1.60189268
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57730718
33LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56836770
34CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.53384588
35CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.52495960
36E2F4_17652178_ChIP-ChIP_JURKAT_Human1.52208478
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.51037872
38FUS_26573619_Chip-Seq_HEK293_Human1.48937583
39CRX_20693478_ChIP-Seq_RETINA_Mouse1.48847722
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.47818508
41OCT4_21477851_ChIP-Seq_ESCs_Mouse1.42041473
42BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.36970831
43IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33855724
44CBP_20019798_ChIP-Seq_JUKART_Human1.33855724
45FOXP3_21729870_ChIP-Seq_TREG_Human1.32501567
46TP53_22573176_ChIP-Seq_HFKS_Human1.31728183
47NOTCH1_21737748_ChIP-Seq_TLL_Human1.30398499
48MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.29903675
49EWS_26573619_Chip-Seq_HEK293_Human1.29104012
50GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.28844626
51UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27923181
52P300_19829295_ChIP-Seq_ESCs_Human1.26784040
53SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.22975595
54EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.21945944
55NANOG_19829295_ChIP-Seq_ESCs_Human1.21436031
56SOX2_19829295_ChIP-Seq_ESCs_Human1.21436031
57RBPJ_22232070_ChIP-Seq_NCS_Mouse1.20510107
58MYC_18940864_ChIP-ChIP_HL60_Human1.20209318
59SALL4_22934838_ChIP-ChIP_CD34+_Human1.19244621
60FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.17415393
61CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.15873980
62NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.14530620
63IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.13756516
64ELK1_22589737_ChIP-Seq_MCF10A_Human1.09916794
65GATA1_22025678_ChIP-Seq_K562_Human1.08960017
66PADI4_21655091_ChIP-ChIP_MCF-7_Human1.08591373
67EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.07870401
68PRDM14_20953172_ChIP-Seq_ESCs_Human1.06066538
69IRF8_21731497_ChIP-ChIP_J774_Mouse1.04075770
70FLI1_21867929_ChIP-Seq_TH2_Mouse1.03323726
71STAT3_18555785_Chip-Seq_ESCs_Mouse1.03318366
72TP53_18474530_ChIP-ChIP_U2OS_Human1.02069676
73AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00663105
74SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.00232144
75SMAD4_21799915_ChIP-Seq_A2780_Human1.00111581
76TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99841972
77FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99633445
78SOX2_18555785_Chip-Seq_ESCs_Mouse0.99369169
79TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98747300
80TCF4_22108803_ChIP-Seq_LS180_Human0.98648948
81STAT3_23295773_ChIP-Seq_U87_Human0.98362892
82DCP1A_22483619_ChIP-Seq_HELA_Human0.97947042
83P300_18555785_Chip-Seq_ESCs_Mouse0.97872378
84EGR1_23403033_ChIP-Seq_LIVER_Mouse0.97575447
85KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97330935
86SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.96434183
87STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.95536847
88TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94977637
89TCF4_23295773_ChIP-Seq_U87_Human0.94042030
90YY1_21170310_ChIP-Seq_MESCs_Mouse0.93964235
91HTT_18923047_ChIP-ChIP_STHdh_Human0.93911802
92EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92925966
93HOXB4_20404135_ChIP-ChIP_EML_Mouse0.92906458
94EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.91051314
95NMYC_18555785_Chip-Seq_ESCs_Mouse0.89177035
96CTBP1_25329375_ChIP-Seq_LNCAP_Human0.88882376
97P53_22387025_ChIP-Seq_ESCs_Mouse0.88788795
98SMAD3_21741376_ChIP-Seq_EPCs_Human0.88667610
99STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.88526852
100E2F1_18555785_Chip-Seq_ESCs_Mouse0.88469636

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001873_stomach_inflammation7.94358981
2MP0004782_abnormal_surfactant_physiolog6.98506448
3MP0001835_abnormal_antigen_presentation6.10064268
4MP0010307_abnormal_tumor_latency4.81202829
5MP0001958_emphysema4.75218698
6MP0005671_abnormal_response_to3.89545161
7MP0009333_abnormal_splenocyte_physiolog3.39393459
8MP0009785_altered_susceptibility_to3.03311119
9MP0002405_respiratory_system_inflammati2.88043234
10MP0003436_decreased_susceptibility_to2.52873351
11MP0005387_immune_system_phenotype2.19623637
12MP0001790_abnormal_immune_system2.19623637
13MP0003186_abnormal_redox_activity2.19425838
14MP0002148_abnormal_hypersensitivity_rea2.18901675
15MP0009780_abnormal_chondrocyte_physiolo2.13611471
16MP0000685_abnormal_immune_system2.12821688
17MP0003950_abnormal_plasma_membrane2.03692136
18MP0005000_abnormal_immune_tolerance1.83497808
19MP0002933_joint_inflammation1.59399638
20MP0001800_abnormal_humoral_immune1.55512583
21MP0001881_abnormal_mammary_gland1.52127736
22MP0008877_abnormal_DNA_methylation1.46956693
23MP0005501_abnormal_skin_physiology1.42554164
24MP0001663_abnormal_digestive_system1.38603872
25MP0010155_abnormal_intestine_physiology1.38095577
26MP0003195_calcinosis1.26197581
27MP0005166_decreased_susceptibility_to1.23762597
28MP0005310_abnormal_salivary_gland1.17742339
29MP0008058_abnormal_DNA_repair1.15087839
30MP0000427_abnormal_hair_cycle1.14705657
31MP0009765_abnormal_xenobiotic_induced1.11470332
32MP0006035_abnormal_mitochondrial_morpho1.08444811
33MP0008569_lethality_at_weaning1.06003035
34MP0003806_abnormal_nucleotide_metabolis1.02815811
35MP0003448_altered_tumor_morphology1.02810853
36MP0005646_abnormal_pituitary_gland1.00558063
37MP0008775_abnormal_heart_ventricle1.00346170
38MP0004142_abnormal_muscle_tone0.96780929
39MP0006054_spinal_hemorrhage0.96613097
40MP0001533_abnormal_skeleton_physiology0.93126871
41MP0000569_abnormal_digit_pigmentation0.92986738
42MP0002138_abnormal_hepatobiliary_system0.91943250
43MP0010094_abnormal_chromosome_stability0.87143423
44MP0004133_heterotaxia0.86956068
45MP0002693_abnormal_pancreas_physiology0.85258941
46MP0006072_abnormal_retinal_apoptosis0.84565016
47MP0004147_increased_porphyrin_level0.84324435
48MP0005381_digestive/alimentary_phenotyp0.83856916
49MP0002234_abnormal_pharynx_morphology0.83820851
50MP0008872_abnormal_physiological_respon0.83645311
51MP0008875_abnormal_xenobiotic_pharmacok0.82805135
52MP0003567_abnormal_fetal_cardiomyocyte0.80528430
53MP0001501_abnormal_sleep_pattern0.80018967
54MP0001293_anophthalmia0.79884896
55MP0000689_abnormal_spleen_morphology0.77284564
56MP0008770_decreased_survivor_rate0.77260608
57MP0005551_abnormal_eye_electrophysiolog0.77074573
58MP0009764_decreased_sensitivity_to0.74872564
59MP0001119_abnormal_female_reproductive0.74753074
60MP0001502_abnormal_circadian_rhythm0.74198832
61MP0001853_heart_inflammation0.74050214
62MP0003252_abnormal_bile_duct0.73327335
63MP0002136_abnormal_kidney_physiology0.73275920
64MP0002254_reproductive_system_inflammat0.73051474
65MP0000358_abnormal_cell_content/0.69997818
66MP0002452_abnormal_antigen_presenting0.69831912
67MP0002722_abnormal_immune_system0.69445304
68MP0000383_abnormal_hair_follicle0.68958371
69MP0005365_abnormal_bile_salt0.68211199
70MP0009697_abnormal_copulation0.67571737
71MP0003122_maternal_imprinting0.66344183
72MP0002420_abnormal_adaptive_immunity0.65612305
73MP0002723_abnormal_immune_serum0.64211326
74MP0001819_abnormal_immune_cell0.63377617
75MP0002419_abnormal_innate_immunity0.62392536
76MP0002166_altered_tumor_susceptibility0.60837545
77MP0006036_abnormal_mitochondrial_physio0.60230400
78MP0002019_abnormal_tumor_incidence0.59866843
79MP0010771_integument_phenotype0.59201645
80MP0003890_abnormal_embryonic-extraembry0.57590899
81MP0006292_abnormal_olfactory_placode0.56041274
82MP0002210_abnormal_sex_determination0.55544682
83MP0004197_abnormal_fetal_growth/weight/0.55260608
84MP0002837_dystrophic_cardiac_calcinosis0.54089754
85MP0005390_skeleton_phenotype0.53991150
86MP0005319_abnormal_enzyme/_coenzyme0.53037264
87MP0001845_abnormal_inflammatory_respons0.52698638
88MP0008873_increased_physiological_sensi0.50066280
89MP0005084_abnormal_gallbladder_morpholo0.49098037
90MP0003936_abnormal_reproductive_system0.48051852
91MP0000627_abnormal_mammary_gland0.46973057
92MP0000653_abnormal_sex_gland0.46219449
93MP0001756_abnormal_urination0.45847457
94MP0005083_abnormal_biliary_tract0.45713687
95MP0001175_abnormal_lung_morphology0.44928710
96MP0005388_respiratory_system_phenotype0.44586238
97MP0002133_abnormal_respiratory_system0.44586238
98MP0001764_abnormal_homeostasis0.44250245
99MP0008438_abnormal_cutaneous_collagen0.43534427
100MP0005253_abnormal_eye_physiology0.42909671

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)4.98619409
2IgA deficiency (HP:0002720)4.61573883
3Type 2 muscle fiber atrophy (HP:0003554)4.47425062
4Abnormality of the pons (HP:0007361)3.90443489
5Muscle fiber atrophy (HP:0100295)3.87904235
6Glucose intolerance (HP:0000833)3.70063536
7Acute necrotizing encephalopathy (HP:0006965)3.57783012
8Attenuation of retinal blood vessels (HP:0007843)3.56732608
9Hypoplasia of the pons (HP:0012110)3.48428133
10Progressive macrocephaly (HP:0004481)3.47457327
11Aplasia/hypoplasia of the humerus (HP:0006507)3.33308799
12Acute encephalopathy (HP:0006846)3.32889291
13Carpal bone hypoplasia (HP:0001498)3.20473983
14Short humerus (HP:0005792)3.18729926
15Abnormal mitochondria in muscle tissue (HP:0008316)3.04125524
16Biconcave vertebral bodies (HP:0004586)3.01418459
17Prolonged partial thromboplastin time (HP:0003645)2.92860346
18Hypoplasia of the capital femoral epiphysis (HP:0003090)2.92830148
19Increased CSF lactate (HP:0002490)2.91272401
20Mitochondrial inheritance (HP:0001427)2.88122824
21Abnormality of T cells (HP:0002843)2.86319964
22IgG deficiency (HP:0004315)2.83241071
23Central scotoma (HP:0000603)2.79636796
24Chronic diarrhea (HP:0002028)2.75223406
25Abnormal glucose tolerance (HP:0001952)2.72090933
26T lymphocytopenia (HP:0005403)2.66450149
27Increased IgM level (HP:0003496)2.65131157
28Absent rod-and cone-mediated responses on ERG (HP:0007688)2.64571743
29Aplastic anemia (HP:0001915)2.62712752
30Oligomenorrhea (HP:0000876)2.62293056
31Abnormality of T cell number (HP:0011839)2.56545585
32Asplenia (HP:0001746)2.52083094
33Abnormality of T cell physiology (HP:0011840)2.51883502
34Aplasia/Hypoplasia of the spleen (HP:0010451)2.47554687
35Abnormal rod and cone electroretinograms (HP:0008323)2.47492140
36Alkalosis (HP:0001948)2.41298438
37Chronic sinusitis (HP:0011109)2.40500726
38Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.36880050
39Posterior subcapsular cataract (HP:0007787)2.32566314
40Abnormality of the proximal phalanges of the hand (HP:0009834)2.31779040
41Absent epiphyses (HP:0010577)2.28607334
42Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.28607334
43Abnormality of the costochondral junction (HP:0000919)2.27793280
44Irregular vertebral endplates (HP:0003301)2.27720233
45Increased serum pyruvate (HP:0003542)2.22246818
46Short 1st metacarpal (HP:0010034)2.21244854
47Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.21244854
48Neonatal respiratory distress (HP:0002643)2.20293674
49Horizontal nystagmus (HP:0000666)2.20191911
50Cerebral edema (HP:0002181)2.17731898
51Hepatocellular necrosis (HP:0001404)2.14189532
52Inability to walk (HP:0002540)2.12756442
53Cerebral hypomyelination (HP:0006808)2.12542301
54Thyroiditis (HP:0100646)2.12473946
55Pancreatic cysts (HP:0001737)2.09784319
56Prominent metopic ridge (HP:0005487)2.09085006
57Progressive microcephaly (HP:0000253)2.03357743
58Delayed epiphyseal ossification (HP:0002663)2.02472707
59Abnormality of the prostate (HP:0008775)2.00347090
60Scotoma (HP:0000575)1.98804954
61Constricted visual fields (HP:0001133)1.94716374
62Duplicated collecting system (HP:0000081)1.93506741
63Hepatic necrosis (HP:0002605)1.92996113
64Abnormality of the 1st metacarpal (HP:0010009)1.92830243
65Abolished electroretinogram (ERG) (HP:0000550)1.92766640
66Poor head control (HP:0002421)1.92203549
67Irregular epiphyses (HP:0010582)1.91909431
68Abnormality of the metopic suture (HP:0005556)1.91575851
69Increased serum lactate (HP:0002151)1.91492398
70Abnormality of the vertebral endplates (HP:0005106)1.91178917
71Metabolic alkalosis (HP:0200114)1.90542117
72Thyroid-stimulating hormone excess (HP:0002925)1.89695965
73Abnormality of the labia minora (HP:0012880)1.89616305
74Autoimmune hemolytic anemia (HP:0001890)1.88544039
75Type I transferrin isoform profile (HP:0003642)1.87184443
76Congenital stationary night blindness (HP:0007642)1.85782261
77Optic disc pallor (HP:0000543)1.85284286
78Congenital, generalized hypertrichosis (HP:0004540)1.84660640
79Polyuria (HP:0000103)1.83947285
80Renal salt wasting (HP:0000127)1.83614343
81Enlarged epiphyses (HP:0010580)1.82313471
82Recurrent fungal infections (HP:0002841)1.81698402
83Abnormality of DNA repair (HP:0003254)1.81612945
84Disproportionate short-trunk short stature (HP:0003521)1.80109373
85Neutropenia (HP:0001875)1.79869280
86Abnormality of the renal collecting system (HP:0004742)1.76580889
87Dyschromatopsia (HP:0007641)1.74913793
88Flattened epiphyses (HP:0003071)1.74216194
89Small hand (HP:0200055)1.74128529
90True hermaphroditism (HP:0010459)1.72891127
91Joint swelling (HP:0001386)1.71970565
92Hypokalemic alkalosis (HP:0001949)1.69810756
93Molar tooth sign on MRI (HP:0002419)1.69624878
94Abnormality of midbrain morphology (HP:0002418)1.69624878
95Small epiphyses (HP:0010585)1.69011627
96Keratoconjunctivitis (HP:0001096)1.68561105
97Keratoconus (HP:0000563)1.68370526
98Increased corneal curvature (HP:0100692)1.68370526
99Metaphyseal irregularity (HP:0003025)1.67912523
100Hypoproteinemia (HP:0003075)1.67580055

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.69002036
2EIF2AK35.16325723
3NME14.39672078
4FRK4.02737472
5EIF2AK13.53356595
6MST42.73267891
7FLT32.44715843
8ADRBK22.17349187
9BMPR1B2.12683281
10TSSK62.08337834
11ACVR1B2.01678584
12CAMKK21.88743905
13SRPK11.84841119
14WNK11.82686953
15BUB11.79296271
16GRK11.78657115
17TLK11.71151487
18PDK21.70803512
19TNIK1.65254538
20VRK21.64408566
21PLK31.62269649
22TNK21.59732138
23PKN21.46743491
24EIF2AK21.45033674
25PRKD31.43702383
26VRK11.29325341
27FGFR11.15429632
28TAOK31.13971595
29MAP4K21.13187427
30ZAK1.13158806
31WNK31.12339669
32AKT31.10562920
33INSRR0.99766058
34DDR20.98511942
35MAP2K60.98505944
36MAP3K70.92050113
37NUAK10.90543615
38ALK0.90228864
39PAK30.88068945
40NLK0.87533437
41PLK20.86414749
42PLK10.79107499
43TGFBR10.78853657
44KIT0.76825779
45MKNK10.76805304
46PIK3CG0.76702634
47NEK60.73197622
48MKNK20.69084909
49STK380.66835051
50ADRBK10.64527828
51ERBB30.64136510
52MAPK130.64006310
53STK100.63953287
54TRIM280.63110506
55MAP4K10.62261548
56CDK60.58010296
57TIE10.56626062
58IKBKB0.55275843
59STK390.51948856
60PDGFRB0.49886143
61OXSR10.48513381
62UHMK10.47454494
63MAP3K120.46558172
64FGFR20.45177740
65SYK0.45166081
66STK38L0.45106041
67CHUK0.45004449
68MUSK0.43842856
69PINK10.43209388
70PHKG20.42079375
71PHKG10.42079375
72STK40.40257607
73JAK30.39159890
74WNK40.38586096
75PIK3CA0.35942053
76LCK0.35922201
77ATM0.35486489
78LATS10.33910930
79PRKCE0.33723837
80PTK2B0.32504139
81PRKCI0.31178949
82TYK20.30604050
83PNCK0.30110399
84BRSK20.30097959
85PRKCG0.28883287
86PRKCA0.28784414
87MAP3K40.28635712
88RPS6KA50.27354758
89PRKCH0.25675048
90CAMKK10.25529537
91JAK20.25419755
92PRKCB0.25214212
93BCKDK0.24608997
94PRKACA0.23872604
95STK110.22493232
96DAPK20.22292686
97WEE10.20289853
98OBSCN0.20013369
99EPHA40.19319253
100GRK60.18695796

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030507.31430144
2Regulation of autophagy_Homo sapiens_hsa041403.62799037
3Allograft rejection_Homo sapiens_hsa053303.17794168
4Rheumatoid arthritis_Homo sapiens_hsa053233.12275360
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.81203706
6Protein export_Homo sapiens_hsa030602.78048516
7Type I diabetes mellitus_Homo sapiens_hsa049402.77097555
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.71957713
9Graft-versus-host disease_Homo sapiens_hsa053322.37873950
10African trypanosomiasis_Homo sapiens_hsa051432.35860295
11T cell receptor signaling pathway_Homo sapiens_hsa046601.99357166
12One carbon pool by folate_Homo sapiens_hsa006701.95275497
13Malaria_Homo sapiens_hsa051441.87411057
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.78300556
15Jak-STAT signaling pathway_Homo sapiens_hsa046301.75317179
16Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.74825711
17RNA polymerase_Homo sapiens_hsa030201.63757957
18Primary bile acid biosynthesis_Homo sapiens_hsa001201.56972879
19Non-homologous end-joining_Homo sapiens_hsa034501.43098349
20Butanoate metabolism_Homo sapiens_hsa006501.42348470
21Antigen processing and presentation_Homo sapiens_hsa046121.41415939
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.39902599
23Salmonella infection_Homo sapiens_hsa051321.37512922
24Amoebiasis_Homo sapiens_hsa051461.33467767
25Homologous recombination_Homo sapiens_hsa034401.32522391
26Hematopoietic cell lineage_Homo sapiens_hsa046401.30397503
27Oxidative phosphorylation_Homo sapiens_hsa001901.29397010
28Primary immunodeficiency_Homo sapiens_hsa053401.27435026
29Vitamin B6 metabolism_Homo sapiens_hsa007501.16857769
30Basal transcription factors_Homo sapiens_hsa030221.16516420
31Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.12983638
32Collecting duct acid secretion_Homo sapiens_hsa049661.09599065
33Linoleic acid metabolism_Homo sapiens_hsa005911.08793544
34Fanconi anemia pathway_Homo sapiens_hsa034601.00489595
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.97277067
36Selenocompound metabolism_Homo sapiens_hsa004500.96806259
37Autoimmune thyroid disease_Homo sapiens_hsa053200.94682930
38Systemic lupus erythematosus_Homo sapiens_hsa053220.94398491
39Parkinsons disease_Homo sapiens_hsa050120.93430933
40Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.90357404
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.89249438
42Peroxisome_Homo sapiens_hsa041460.88292745
43TGF-beta signaling pathway_Homo sapiens_hsa043500.85918543
44Measles_Homo sapiens_hsa051620.84184342
45Folate biosynthesis_Homo sapiens_hsa007900.84029672
46Tryptophan metabolism_Homo sapiens_hsa003800.83155964
47Caffeine metabolism_Homo sapiens_hsa002320.82407547
48RNA degradation_Homo sapiens_hsa030180.80519315
49Propanoate metabolism_Homo sapiens_hsa006400.80283133
50Arachidonic acid metabolism_Homo sapiens_hsa005900.78576973
51Asthma_Homo sapiens_hsa053100.77287257
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.72746386
53Steroid hormone biosynthesis_Homo sapiens_hsa001400.71015895
54Huntingtons disease_Homo sapiens_hsa050160.70550855
55Cysteine and methionine metabolism_Homo sapiens_hsa002700.69116696
56Nitrogen metabolism_Homo sapiens_hsa009100.66626368
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.64776687
58Taste transduction_Homo sapiens_hsa047420.61861429
59HIF-1 signaling pathway_Homo sapiens_hsa040660.58657053
60Leishmaniasis_Homo sapiens_hsa051400.56387609
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54903916
62RNA transport_Homo sapiens_hsa030130.54032172
63TNF signaling pathway_Homo sapiens_hsa046680.52966199
64Intestinal immune network for IgA production_Homo sapiens_hsa046720.51972447
65Epstein-Barr virus infection_Homo sapiens_hsa051690.51203128
66Chemical carcinogenesis_Homo sapiens_hsa052040.49662020
67Ribosome_Homo sapiens_hsa030100.48864907
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48823587
69Mismatch repair_Homo sapiens_hsa034300.47960519
70Nucleotide excision repair_Homo sapiens_hsa034200.47513485
71Spliceosome_Homo sapiens_hsa030400.46390240
72Phototransduction_Homo sapiens_hsa047440.46190659
73Purine metabolism_Homo sapiens_hsa002300.45947724
74Pyrimidine metabolism_Homo sapiens_hsa002400.45051268
75Glutathione metabolism_Homo sapiens_hsa004800.42433933
76Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.42382618
77ABC transporters_Homo sapiens_hsa020100.39798324
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37137856
79Retinol metabolism_Homo sapiens_hsa008300.36993077
80Ether lipid metabolism_Homo sapiens_hsa005650.36916453
81Fatty acid elongation_Homo sapiens_hsa000620.35717368
82Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.34766021
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34196504
84Mineral absorption_Homo sapiens_hsa049780.32438887
85Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.31757795
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31627460
87Ovarian steroidogenesis_Homo sapiens_hsa049130.31455448
88Olfactory transduction_Homo sapiens_hsa047400.31241541
89Fat digestion and absorption_Homo sapiens_hsa049750.29882075
90Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.28927888
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.28689563
92Alzheimers disease_Homo sapiens_hsa050100.25905790
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.25252235
94Herpes simplex infection_Homo sapiens_hsa051680.24784908
95Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.24516675
96N-Glycan biosynthesis_Homo sapiens_hsa005100.23160635
97Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.23160262
98Toxoplasmosis_Homo sapiens_hsa051450.22569880
99Glycerolipid metabolism_Homo sapiens_hsa005610.21565979
100Metabolic pathways_Homo sapiens_hsa011000.21545086

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