SNRPCP6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1limb bud formation (GO:0060174)6.94843773
2lateral sprouting from an epithelium (GO:0060601)6.63944569
3viral transcription (GO:0019083)6.61579054
4translational termination (GO:0006415)6.34201104
5lens fiber cell development (GO:0070307)5.90758675
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.32552170
7cotranslational protein targeting to membrane (GO:0006613)5.31331757
8regulation of vascular endothelial growth factor signaling pathway (GO:1900746)5.27421780
9establishment of protein localization to mitochondrial membrane (GO:0090151)5.21726877
10protein targeting to ER (GO:0045047)5.20534013
11translational elongation (GO:0006414)5.18279360
12cellular protein complex disassembly (GO:0043624)5.07148616
13establishment of protein localization to endoplasmic reticulum (GO:0072599)4.98631443
14nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.84630824
15protein localization to endoplasmic reticulum (GO:0070972)4.77709077
16viral life cycle (GO:0019058)4.74869877
17presynaptic membrane assembly (GO:0097105)4.73257143
18microtubule depolymerization (GO:0007019)4.71176227
19notochord development (GO:0030903)4.67453714
20digestive tract morphogenesis (GO:0048546)4.62040365
21regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.53308890
22mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.47442914
23protein complex disassembly (GO:0043241)4.29326696
24axon ensheathment in central nervous system (GO:0032291)4.27171924
25central nervous system myelination (GO:0022010)4.27171924
26ATP synthesis coupled proton transport (GO:0015986)4.26233032
27energy coupled proton transport, down electrochemical gradient (GO:0015985)4.26233032
28negative regulation of mesenchymal cell apoptotic process (GO:2001054)4.20578793
29ribosomal small subunit assembly (GO:0000028)4.20060168
30ribosomal large subunit biogenesis (GO:0042273)4.20029734
31translational initiation (GO:0006413)4.18152234
32macromolecular complex disassembly (GO:0032984)4.07514962
33prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060524.06936804
34maturation of SSU-rRNA (GO:0030490)4.06312447
35regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.04988888
36ribosomal small subunit biogenesis (GO:0042274)4.04249061
37presynaptic membrane organization (GO:0097090)4.03378674
38endocardial cushion morphogenesis (GO:0003203)3.95745797
39dopaminergic neuron differentiation (GO:0071542)3.78663595
40mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.69189189
41mitochondrial respiratory chain complex I assembly (GO:0032981)3.69189189
42NADH dehydrogenase complex assembly (GO:0010257)3.69189189
43positive regulation of gastrulation (GO:2000543)3.62922790
44forebrain neuron differentiation (GO:0021879)3.62306139
45neuronal stem cell maintenance (GO:0097150)3.61414600
46mitochondrion transport along microtubule (GO:0047497)3.55835896
47establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.55835896
48positive regulation of RNA splicing (GO:0033120)3.54562902
49organ growth (GO:0035265)3.54146581
50regulation of mesenchymal cell apoptotic process (GO:2001053)3.48972984
51heart valve formation (GO:0003188)3.44958668
52protein targeting to membrane (GO:0006612)3.44417166
53somatic stem cell division (GO:0048103)3.38622756
54hindbrain development (GO:0030902)3.38115427
55mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.37803246
56establishment of mitochondrion localization (GO:0051654)3.36015032
57protein-cofactor linkage (GO:0018065)3.30404224
58nuclear-transcribed mRNA catabolic process (GO:0000956)3.29321024
59protein complex biogenesis (GO:0070271)3.29024108
60midbrain development (GO:0030901)3.26071059
61paraxial mesoderm development (GO:0048339)3.25622814
62lung-associated mesenchyme development (GO:0060484)3.18904006
63spinal cord association neuron differentiation (GO:0021527)3.16443110
64mRNA catabolic process (GO:0006402)3.13801815
65negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.13127154
66mesenchyme morphogenesis (GO:0072132)3.12197744
67protein localization to synapse (GO:0035418)3.11530394
68branching involved in labyrinthine layer morphogenesis (GO:0060670)3.09184713
69lung epithelium development (GO:0060428)3.08897371
70neuron cell-cell adhesion (GO:0007158)3.06735662
71nonmotile primary cilium assembly (GO:0035058)3.04709893
72eye photoreceptor cell differentiation (GO:0001754)3.02813267
73photoreceptor cell differentiation (GO:0046530)3.02813267
74nephron tubule formation (GO:0072079)3.00815648
75positive regulation of male gonad development (GO:2000020)2.98107269
76translation (GO:0006412)2.97072112
77regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.96069261
78respiratory electron transport chain (GO:0022904)2.95604577
79pre-miRNA processing (GO:0031054)2.93868987
80lung lobe morphogenesis (GO:0060463)2.93442762
81pattern specification involved in kidney development (GO:0061004)2.92266775
82epithelial tube branching involved in lung morphogenesis (GO:0060441)2.91430815
83mitochondrial respiratory chain complex assembly (GO:0033108)2.90183739
84chondrocyte proliferation (GO:0035988)2.90138894
85chaperone-mediated protein transport (GO:0072321)2.89864251
86chromatin remodeling at centromere (GO:0031055)2.89443198
87genitalia morphogenesis (GO:0035112)2.87872489
88RNA catabolic process (GO:0006401)2.86772962
89electron transport chain (GO:0022900)2.86480087
90negative regulation of glial cell differentiation (GO:0045686)2.85580531
91mitotic metaphase plate congression (GO:0007080)2.82524029
92neuron fate specification (GO:0048665)2.80284858
93primitive streak formation (GO:0090009)2.79614078
94pituitary gland development (GO:0021983)2.79301845
95mesenchymal cell proliferation (GO:0010463)2.75096601
96epithelial cell fate commitment (GO:0072148)2.74944575
97Sertoli cell development (GO:0060009)2.74756702
98cochlea morphogenesis (GO:0090103)2.71920391
99metaphase plate congression (GO:0051310)2.71161006
100otic vesicle formation (GO:0030916)10.4676592

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.53115515
2IGF1R_20145208_ChIP-Seq_DFB_Human3.40929206
3MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.33874685
4FOXM1_23109430_ChIP-Seq_U2OS_Human2.91178865
5EWS_26573619_Chip-Seq_HEK293_Human2.77415007
6TP63_19390658_ChIP-ChIP_HaCaT_Human2.63836470
7CBX2_27304074_Chip-Seq_ESCs_Mouse2.61681155
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.60159963
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.57409294
10RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.54898217
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.52571018
12FUS_26573619_Chip-Seq_HEK293_Human2.47323248
13POU5F1_16153702_ChIP-ChIP_HESCs_Human2.23092072
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.18583268
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.06134470
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.05665745
17GBX2_23144817_ChIP-Seq_PC3_Human2.04483635
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.03112184
19RBPJ_22232070_ChIP-Seq_NCS_Mouse2.01099695
20ZFP57_27257070_Chip-Seq_ESCs_Mouse2.00770975
21RNF2_27304074_Chip-Seq_NSC_Mouse1.98757499
22POU3F2_20337985_ChIP-ChIP_501MEL_Human1.97278977
23BMI1_23680149_ChIP-Seq_NPCS_Mouse1.95031797
24ZNF274_21170338_ChIP-Seq_K562_Hela1.93699216
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.93102401
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.93036538
27ELK1_19687146_ChIP-ChIP_HELA_Human1.91966059
28E2F4_17652178_ChIP-ChIP_JURKAT_Human1.90150037
29P300_19829295_ChIP-Seq_ESCs_Human1.84074460
30EZH2_27304074_Chip-Seq_ESCs_Mouse1.73556363
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.72387359
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.69508023
33TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69319791
34POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.69319791
35KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.68960159
36MYC_18555785_ChIP-Seq_MESCs_Mouse1.61568675
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.60178984
38MYC_19079543_ChIP-ChIP_MESCs_Mouse1.56582971
39PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.55841063
40CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.54854874
41RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.53894501
42JARID2_20064375_ChIP-Seq_MESCs_Mouse1.53183937
43SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46613005
44TAF15_26573619_Chip-Seq_HEK293_Human1.45941387
45VDR_22108803_ChIP-Seq_LS180_Human1.45785523
46HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.43912137
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.43542475
48SOX2_16153702_ChIP-ChIP_HESCs_Human1.39303173
49MYC_18940864_ChIP-ChIP_HL60_Human1.37844551
50GATA1_26923725_Chip-Seq_HPCs_Mouse1.33572760
51TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.32416411
52EED_16625203_ChIP-ChIP_MESCs_Mouse1.29827912
53CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29329342
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.28971420
55MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.27512084
56JARID2_20075857_ChIP-Seq_MESCs_Mouse1.26240984
57XRN2_22483619_ChIP-Seq_HELA_Human1.25546433
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25244591
59RNF2_27304074_Chip-Seq_ESCs_Mouse1.24909493
60AR_25329375_ChIP-Seq_VCAP_Human1.23654134
61KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.21726037
62KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.21726037
63KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.21726037
64SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21562736
65RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19697900
66TP53_20018659_ChIP-ChIP_R1E_Mouse1.17480992
67SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.15069780
68TTF2_22483619_ChIP-Seq_HELA_Human1.14201454
69TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13496200
70SOX2_19829295_ChIP-Seq_ESCs_Human1.11151622
71NANOG_19829295_ChIP-Seq_ESCs_Human1.11151622
72PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10032803
73SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.08987873
74KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08743697
75MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08634657
76CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.08525010
77SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.07954645
78GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05779623
79UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05752112
80NANOG_16153702_ChIP-ChIP_HESCs_Human1.04776957
81POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.04772904
82ER_23166858_ChIP-Seq_MCF-7_Human1.03700885
83SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.03567095
84SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.02666617
85OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02078450
86CREB1_15753290_ChIP-ChIP_HEK293T_Human1.00399280
87ETS1_20019798_ChIP-Seq_JURKAT_Human0.99858703
88IRF1_19129219_ChIP-ChIP_H3396_Human0.98243311
89NFYB_21822215_ChIP-Seq_K562_Human0.98169398
90HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.97877340
91RNF2_18974828_ChIP-Seq_MESCs_Mouse0.97707781
92EZH2_18974828_ChIP-Seq_MESCs_Mouse0.97707781
93RUNX2_22187159_ChIP-Seq_PCA_Human0.97386696
94RXR_22108803_ChIP-Seq_LS180_Human0.96840440
95TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96619698
96AR_21572438_ChIP-Seq_LNCaP_Human0.96445325
97TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96234167
98STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.93843250
99RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.93050293
100TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92705737

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color8.61620918
2MP0000566_synostosis7.55072730
3MP0000537_abnormal_urethra_morphology3.33297568
4MP0009379_abnormal_foot_pigmentation2.86299989
5MP0001346_abnormal_lacrimal_gland2.51668002
6MP0003122_maternal_imprinting2.50266791
7MP0000569_abnormal_digit_pigmentation2.30355486
8MP0003890_abnormal_embryonic-extraembry2.19775024
9MP0003315_abnormal_perineum_morphology2.15894437
10MP0002282_abnormal_trachea_morphology2.12345912
11MP0004885_abnormal_endolymph2.12204275
12MP0002938_white_spotting2.06917029
13MP0005187_abnormal_penis_morphology1.95498587
14MP0002638_abnormal_pupillary_reflex1.93732438
15MP0008995_early_reproductive_senescence1.87398972
16MP0000647_abnormal_sebaceous_gland1.86774182
17MP0002095_abnormal_skin_pigmentation1.82541272
18MP0003121_genomic_imprinting1.73531331
19MP0001299_abnormal_eye_distance/1.67967683
20MP0000049_abnormal_middle_ear1.61856654
21MP0009780_abnormal_chondrocyte_physiolo1.60441518
22MP0004742_abnormal_vestibular_system1.59085367
23MP0002277_abnormal_respiratory_mucosa1.58204231
24MP0000631_abnormal_neuroendocrine_gland1.55014449
25MP0000383_abnormal_hair_follicle1.53674624
26MP0003123_paternal_imprinting1.51424939
27MP0001485_abnormal_pinna_reflex1.45577331
28MP0001986_abnormal_taste_sensitivity1.38894633
29MP0000778_abnormal_nervous_system1.38526705
30MP0003937_abnormal_limbs/digits/tail_de1.36427115
31MP0005075_abnormal_melanosome_morpholog1.36157397
32MP0000579_abnormal_nail_morphology1.33973979
33MP0004142_abnormal_muscle_tone1.33772792
34MP0010030_abnormal_orbit_morphology1.32717687
35MP0001529_abnormal_vocalization1.30279536
36MP0001293_anophthalmia1.27558131
37MP0003787_abnormal_imprinting1.27197837
38MP0003755_abnormal_palate_morphology1.26419545
39MP0005670_abnormal_white_adipose1.24286744
40MP0009250_abnormal_appendicular_skeleto1.23841186
41MP0000762_abnormal_tongue_morphology1.21201167
42MP0002653_abnormal_ependyma_morphology1.14435070
43MP0003941_abnormal_skin_development1.13087868
44MP0001286_abnormal_eye_development1.09528432
45MP0000427_abnormal_hair_cycle1.05904882
46MP0003880_abnormal_central_pattern1.05817063
47MP0002751_abnormal_autonomic_nervous1.03289990
48MP0003938_abnormal_ear_development1.02852239
49MP0003119_abnormal_digestive_system1.02748335
50MP0000026_abnormal_inner_ear1.02210762
51MP0000462_abnormal_digestive_system1.01688111
52MP0002249_abnormal_larynx_morphology1.01669379
53MP0001324_abnormal_eye_pigmentation0.99129829
54MP0005174_abnormal_tail_pigmentation0.90329266
55MP0000955_abnormal_spinal_cord0.89051282
56MP0002233_abnormal_nose_morphology0.88761681
57MP0001984_abnormal_olfaction0.88647556
58MP0005551_abnormal_eye_electrophysiolog0.87100801
59MP0008877_abnormal_DNA_methylation0.86757935
60MP0002697_abnormal_eye_size0.86731365
61MP0003186_abnormal_redox_activity0.85268674
62MP0010678_abnormal_skin_adnexa0.85114809
63MP0009672_abnormal_birth_weight0.83304872
64MP0002111_abnormal_tail_morphology0.83102441
65MP0005083_abnormal_biliary_tract0.82821656
66MP0006292_abnormal_olfactory_placode0.81710178
67MP0002067_abnormal_sensory_capabilities0.81657039
68MP0006072_abnormal_retinal_apoptosis0.81528948
69MP0005084_abnormal_gallbladder_morpholo0.81065042
70MP0000534_abnormal_ureter_morphology0.79430849
71MP0004957_abnormal_blastocyst_morpholog0.78786663
72MP0003011_delayed_dark_adaptation0.78365194
73MP0004381_abnormal_hair_follicle0.78121054
74MP0000639_abnormal_adrenal_gland0.76078777
75MP0002752_abnormal_somatic_nervous0.73588615
76MP0000428_abnormal_craniofacial_morphol0.73376729
77MP0002837_dystrophic_cardiac_calcinosis0.72874451
78MP0001968_abnormal_touch/_nociception0.71015382
79MP0005253_abnormal_eye_physiology0.71005329
80MP0000538_abnormal_urinary_bladder0.70045814
81MP0001177_atelectasis0.69427523
82MP0001963_abnormal_hearing_physiology0.66638839
83MP0005171_absent_coat_pigmentation0.66206753
84MP0003943_abnormal_hepatobiliary_system0.64715605
85MP0004270_analgesia0.64089371
86MP0005195_abnormal_posterior_eye0.63574100
87MP0003567_abnormal_fetal_cardiomyocyte0.62913857
88MP0002557_abnormal_social/conspecific_i0.62575547
89MP0005386_behavior/neurological_phenoty0.62010339
90MP0004924_abnormal_behavior0.62010339
91MP0003861_abnormal_nervous_system0.61900222
92MP0002184_abnormal_innervation0.60302126
93MP0002210_abnormal_sex_determination0.59541722
94MP0002109_abnormal_limb_morphology0.59308684
95MP0005423_abnormal_somatic_nervous0.59175494
96MP0002272_abnormal_nervous_system0.58837095
97MP0008932_abnormal_embryonic_tissue0.57500771
98MP0004145_abnormal_muscle_electrophysio0.57014673
99MP0002734_abnormal_mechanical_nocicepti0.56134149
100MP0002234_abnormal_pharynx_morphology0.55474456

Predicted human phenotypes

RankGene SetZ-score
1Partial duplication of thumb phalanx (HP:0009944)5.93914949
2Coronal craniosynostosis (HP:0004440)5.91042110
3Partial duplication of the phalanx of hand (HP:0009999)5.54972445
4Septo-optic dysplasia (HP:0100842)5.48994480
5Abnormality of incisor morphology (HP:0011063)4.66896491
6Abnormality of the labia minora (HP:0012880)4.53518020
7Aplasia involving bones of the upper limbs (HP:0009823)4.51228150
8Aplasia of the phalanges of the hand (HP:0009802)4.51228150
9Aplasia involving bones of the extremities (HP:0009825)4.51228150
10Abnormality of the parietal bone (HP:0002696)4.35764637
11Neonatal short-limb short stature (HP:0008921)4.35069308
12Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)4.19719179
13Abnormality of the middle phalanges of the toes (HP:0010183)4.16725784
14Absent septum pellucidum (HP:0001331)3.96363881
15Conical tooth (HP:0000698)3.92175826
16Esophageal atresia (HP:0002032)3.87129865
17Megalencephaly (HP:0001355)3.85974826
18Nasolacrimal duct obstruction (HP:0000579)3.64461133
19Abnormality of the lacrimal duct (HP:0011481)3.56317543
20True hermaphroditism (HP:0010459)3.36538738
21Abnormality of the septum pellucidum (HP:0007375)3.32400942
22Alacrima (HP:0000522)3.32383932
23Stenosis of the external auditory canal (HP:0000402)3.29145213
24Abnormality of the nasolacrimal system (HP:0000614)3.22975825
25Bronchomalacia (HP:0002780)3.22617560
26Abnormality of the phalanges of the 2nd finger (HP:0009541)3.16748120
27Duplication of thumb phalanx (HP:0009942)3.16163003
28Down-sloping shoulders (HP:0200021)3.06333409
29Gastrointestinal atresia (HP:0002589)3.04568720
30Aplasia/Hypoplasia of the sternum (HP:0006714)3.00835074
31Thickened helices (HP:0000391)3.00217000
32Cortical dysplasia (HP:0002539)2.96778098
33Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.93463587
34Recurrent corneal erosions (HP:0000495)2.93452961
35Bifid scrotum (HP:0000048)2.88228202
36Abnormality of the 2nd finger (HP:0004100)2.86628850
37Anophthalmia (HP:0000528)2.83189135
38Decreased lacrimation (HP:0000633)2.71235232
39Optic nerve hypoplasia (HP:0000609)2.70908596
40Abnormality of the incisor (HP:0000676)2.69783895
41Broad metatarsal (HP:0001783)2.68455524
42Supernumerary ribs (HP:0005815)2.57672482
43Aqueductal stenosis (HP:0002410)2.52023843
44Supernumerary bones of the axial skeleton (HP:0009144)2.45175855
45Split foot (HP:0001839)2.43464616
4611 pairs of ribs (HP:0000878)2.40688030
47Sex reversal (HP:0012245)2.40138921
48Abnormal sex determination (HP:0012244)2.40138921
49Vaginal atresia (HP:0000148)2.35581725
50Bilateral microphthalmos (HP:0007633)2.34109672
51Vertebral fusion (HP:0002948)2.25612138
52Preaxial foot polydactyly (HP:0001841)2.24389558
53Genital tract atresia (HP:0001827)2.22778007
54Broad distal phalanx of finger (HP:0009836)2.22421355
55Xerostomia (HP:0000217)2.21017851
56Hypoplastic iliac wings (HP:0002866)2.18987241
57Broad hallux (HP:0010055)2.18179384
58Respiratory distress (HP:0002098)2.17453373
59Overriding aorta (HP:0002623)2.14498108
60Missing ribs (HP:0000921)2.14083429
61Hypoplasia of the ulna (HP:0003022)2.13993663
62Abnormality of cells of the erythroid lineage (HP:0012130)2.13589749
63Stomach cancer (HP:0012126)2.12696638
64Synostosis involving the elbow (HP:0003938)2.12292439
65Humeroradial synostosis (HP:0003041)2.12292439
66Cutaneous finger syndactyly (HP:0010554)2.11816438
67Mixed hearing impairment (HP:0000410)2.09953761
68Abnormality of the antihelix (HP:0009738)2.06982977
69Sleep apnea (HP:0010535)2.06705231
70Increased hepatocellular lipid droplets (HP:0006565)2.05514721
71Abnormality of the salivary glands (HP:0010286)2.03806700
72Chronic otitis media (HP:0000389)2.03331780
73Cutaneous syndactyly (HP:0012725)2.02946416
74Abnormal number of erythroid precursors (HP:0012131)2.02040845
75Short 4th metacarpal (HP:0010044)2.00959173
76Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.00959173
77Macrocytic anemia (HP:0001972)2.00940640
78Hemivertebrae (HP:0002937)2.00009817
79Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.99983116
80Abnormality of the distal phalanx of the thumb (HP:0009617)1.99925808
81Pancreatic cysts (HP:0001737)1.99595832
82Reticulocytopenia (HP:0001896)1.98898313
83Cupped ear (HP:0000378)1.95151585
84Absent radius (HP:0003974)1.93731096
85Hypoplastic ilia (HP:0000946)1.92750851
86Intestinal atresia (HP:0011100)1.91346313
87Medial flaring of the eyebrow (HP:0010747)1.90547237
88Neoplasm of the heart (HP:0100544)1.90446374
89Abnormality of the musculature of the hand (HP:0001421)1.89986806
90Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.88230345
91Vertebral hypoplasia (HP:0008417)1.88230345
92Short hallux (HP:0010109)1.84153773
93Hypoplasia of the radius (HP:0002984)1.82441098
94Absent forearm bone (HP:0003953)1.81883218
95Aplasia involving forearm bones (HP:0009822)1.81883218
96Hyperglycinuria (HP:0003108)1.81077472
97Short phalanx of the thumb (HP:0009660)1.78949606
98Broad toe (HP:0001837)1.77429565
99Choanal stenosis (HP:0000452)1.76527985
100Hyperglycinemia (HP:0002154)1.76373420

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR25.73684092
2PNCK5.29604676
3WEE14.01217582
4PINK13.56046543
5BUB13.16758199
6TNIK2.62255896
7STK162.57190041
8CASK2.51904189
9EPHB22.51134378
10WNK32.39362395
11LATS12.34906072
12FGFR12.33445520
13CDK192.13313447
14VRK22.03099858
15LATS21.94436478
16NME11.91539309
17VRK11.86423490
18NUAK11.80380243
19MAP3K61.79905649
20PDK21.76448409
21NEK21.67730935
22EPHA41.55317266
23UHMK11.52007847
24MKNK21.41280065
25DYRK21.36865796
26PASK1.35584062
27TTK1.35016177
28DYRK31.33935709
29MAPK151.33578524
30FGFR31.33344607
31MKNK11.27457525
32TAF11.17542913
33STK31.04931294
34ZAK0.96776630
35PBK0.96115374
36PLK30.93691145
37MST40.93148785
38LIMK10.89906942
39MARK10.86047485
40ADRBK10.85081244
41BMPR1B0.82029440
42PLK40.81927839
43NTRK20.79654255
44STK38L0.79211640
45ERBB20.77325608
46ACVR1B0.76514284
47EIF2AK20.75305375
48CDC70.74992711
49TGFBR10.74690289
50CSNK1G10.73738856
51YES10.73656459
52SRPK10.71726041
53PRKCG0.68178988
54TSSK60.61800371
55ADRBK20.58569343
56TAOK30.57728471
57RPS6KA40.57595844
58MAPK130.57514236
59ALK0.55747915
60ERBB40.54336452
61DYRK1A0.53533175
62CSNK1G20.53300634
63DYRK1B0.51699702
64NLK0.50930925
65ROCK10.47617288
66WNK40.45659405
67FLT30.44372792
68PLK10.44124018
69CSNK1E0.42853559
70MAP2K40.37775813
71BRAF0.37455851
72KSR10.37385998
73TGFBR20.36797914
74CDK80.35827170
75WNK10.34992633
76MAP2K70.33918370
77PTK60.33663109
78CSNK1G30.33266897
79INSRR0.31808858
80MINK10.31341283
81MAP2K60.31004223
82CSNK2A20.30661974
83AURKB0.30368870
84MAPKAPK50.29216922
85STK40.27995405
86AKT20.26806376
87CHUK0.26674001
88IRAK20.26570468
89PRKACA0.26446861
90CDK30.23419532
91GRK10.23291804
92MAP3K100.22976406
93CSNK2A10.22632200
94PIM10.21565409
95OBSCN0.21042087
96IRAK40.20726704
97PRKG10.20602804
98CSNK1A10.19534888
99IRAK10.18539774
100LRRK20.17323169

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030107.17634420
2Oxidative phosphorylation_Homo sapiens_hsa001904.48078113
3Parkinsons disease_Homo sapiens_hsa050123.70539857
4Huntingtons disease_Homo sapiens_hsa050162.70002381
5Proteasome_Homo sapiens_hsa030502.62273464
6Alzheimers disease_Homo sapiens_hsa050102.47250633
7Cardiac muscle contraction_Homo sapiens_hsa042602.46686141
8Protein export_Homo sapiens_hsa030602.32246394
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.30664236
10Mismatch repair_Homo sapiens_hsa034302.19083126
11Basal transcription factors_Homo sapiens_hsa030222.18183691
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.93745355
13Spliceosome_Homo sapiens_hsa030401.86350059
14RNA polymerase_Homo sapiens_hsa030201.84363398
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.84010055
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.83102868
17Propanoate metabolism_Homo sapiens_hsa006401.71058655
18Nicotine addiction_Homo sapiens_hsa050331.64563821
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.56419085
20Basal cell carcinoma_Homo sapiens_hsa052171.48288765
21Folate biosynthesis_Homo sapiens_hsa007901.46810970
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.43683014
23One carbon pool by folate_Homo sapiens_hsa006701.43580568
24Homologous recombination_Homo sapiens_hsa034401.31113532
25Pyruvate metabolism_Homo sapiens_hsa006201.30229454
26Phototransduction_Homo sapiens_hsa047441.29951874
27Steroid biosynthesis_Homo sapiens_hsa001001.26215655
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.24981949
29RNA transport_Homo sapiens_hsa030131.22380551
30DNA replication_Homo sapiens_hsa030301.16515513
31p53 signaling pathway_Homo sapiens_hsa041151.14550145
32Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.12042891
33Hedgehog signaling pathway_Homo sapiens_hsa043401.05376271
34Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.03281756
35Olfactory transduction_Homo sapiens_hsa047401.01173443
36Glycerolipid metabolism_Homo sapiens_hsa005610.95060770
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.91740948
38Nucleotide excision repair_Homo sapiens_hsa034200.89548866
39Nitrogen metabolism_Homo sapiens_hsa009100.88581818
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87721246
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.84577416
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83401073
43Cocaine addiction_Homo sapiens_hsa050300.75864418
44Purine metabolism_Homo sapiens_hsa002300.73918056
45Wnt signaling pathway_Homo sapiens_hsa043100.73124669
46Fanconi anemia pathway_Homo sapiens_hsa034600.71525541
47TGF-beta signaling pathway_Homo sapiens_hsa043500.71165513
48Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69714456
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.69633183
50Hippo signaling pathway_Homo sapiens_hsa043900.67702473
51RNA degradation_Homo sapiens_hsa030180.67048947
52Peroxisome_Homo sapiens_hsa041460.66281732
53Base excision repair_Homo sapiens_hsa034100.65071455
54Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.64858742
55Taste transduction_Homo sapiens_hsa047420.62851299
56beta-Alanine metabolism_Homo sapiens_hsa004100.61163425
57Fat digestion and absorption_Homo sapiens_hsa049750.60524432
58Retinol metabolism_Homo sapiens_hsa008300.59864811
59Cell cycle_Homo sapiens_hsa041100.57801892
60Metabolic pathways_Homo sapiens_hsa011000.56830083
61Insulin secretion_Homo sapiens_hsa049110.56155819
62Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.54213285
63Collecting duct acid secretion_Homo sapiens_hsa049660.52776045
64Arginine and proline metabolism_Homo sapiens_hsa003300.52548246
65Morphine addiction_Homo sapiens_hsa050320.52237075
66Linoleic acid metabolism_Homo sapiens_hsa005910.51971498
67Butanoate metabolism_Homo sapiens_hsa006500.49522894
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46124371
69Serotonergic synapse_Homo sapiens_hsa047260.45456473
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45131657
71Chemical carcinogenesis_Homo sapiens_hsa052040.43052734
72Tyrosine metabolism_Homo sapiens_hsa003500.40968362
73Tryptophan metabolism_Homo sapiens_hsa003800.40903130
74mRNA surveillance pathway_Homo sapiens_hsa030150.40501526
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40105752
76Starch and sucrose metabolism_Homo sapiens_hsa005000.40104677
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39585152
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.39071297
79Pyrimidine metabolism_Homo sapiens_hsa002400.38947442
80Glutamatergic synapse_Homo sapiens_hsa047240.33618232
81Prostate cancer_Homo sapiens_hsa052150.32090974
82Sulfur relay system_Homo sapiens_hsa041220.31750123
83Alcoholism_Homo sapiens_hsa050340.30835704
84Central carbon metabolism in cancer_Homo sapiens_hsa052300.30710573
85Circadian entrainment_Homo sapiens_hsa047130.30298456
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.29875929
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26940170
88Mineral absorption_Homo sapiens_hsa049780.26604281
89cAMP signaling pathway_Homo sapiens_hsa040240.26004459
90African trypanosomiasis_Homo sapiens_hsa051430.24887604
91Cysteine and methionine metabolism_Homo sapiens_hsa002700.24731754
92Axon guidance_Homo sapiens_hsa043600.24624669
93Colorectal cancer_Homo sapiens_hsa052100.21734807
94GABAergic synapse_Homo sapiens_hsa047270.21230528
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.19965773
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.18297812
97Vitamin digestion and absorption_Homo sapiens_hsa049770.18280812
98Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.18114140
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.16605166
100Glutathione metabolism_Homo sapiens_hsa004800.16521621

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