ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pyrimidine ribonucleoside catabolic process (GO:0046133)	9.88566313
2	DNA deamination (GO:0045006)	8.77887557
3	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	7.97242299
4	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	5.08353334
5	response to pheromone (GO:0019236)	5.02714014
6	cytolysis (GO:0019835)	4.74846844
7	pyrimidine nucleoside catabolic process (GO:0046135)	4.68239427
8	regulation of cilium movement (GO:0003352)	4.52064499
9	ribosomal small subunit assembly (GO:0000028)	4.47115830
10	pyrimidine ribonucleoside metabolic process (GO:0046131)	4.07045727
11	chaperone-mediated protein transport (GO:0072321)	3.90705373
12	dopamine transport (GO:0015872)	3.77382467
13	DNA double-strand break processing (GO:0000729)	3.72765379
14	ncRNA 3-end processing (GO:0043628)	3.65662363
15	platelet dense granule organization (GO:0060155)	3.62413990
16	axonemal dynein complex assembly (GO:0070286)	3.53870986
17	pyrimidine-containing compound catabolic process (GO:0072529)	3.50524145
18	DNA demethylation (GO:0080111)	3.39709843
19	acrosome reaction (GO:0007340)	3.36953662
20	negative regulation of execution phase of apoptosis (GO:1900118)	3.33908875
21	DNA dealkylation (GO:0035510)	3.30509276
22	protein-cofactor linkage (GO:0018065)	3.25767714
23	killing of cells of other organism (GO:0031640)	3.25294117
24	disruption of cells of other organism (GO:0044364)	3.25294117
25	striatum development (GO:0021756)	3.15860237
26	transmission of nerve impulse (GO:0019226)	3.15074745
27	regulation of mitochondrial translation (GO:0070129)	3.11708454
28	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	3.07013912
29	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	3.07013912
30	synaptic transmission, dopaminergic (GO:0001963)	3.06096355
31	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.99057431
32	regulation of timing of cell differentiation (GO:0048505)	2.98186025
33	DNA integration (GO:0015074)	2.95873667
34	negative regulation of activin receptor signaling pathway (GO:0032926)	2.91759629
35	maturation of SSU-rRNA (GO:0030490)	2.91066800
36	pyrimidine nucleoside metabolic process (GO:0006213)	2.85806665
37	regulation of development, heterochronic (GO:0040034)	2.82666070
38	defense response to fungus (GO:0050832)	2.82170905
39	regulation of neurotransmitter uptake (GO:0051580)	2.81948092
40	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.81707131
41	termination of RNA polymerase III transcription (GO:0006386)	2.81707131
42	multicellular organismal aging (GO:0010259)	2.76283936
43	behavioral response to nicotine (GO:0035095)	2.75886748
44	head development (GO:0060322)	2.74881838
45	negative regulation of T cell apoptotic process (GO:0070233)	2.73665924
46	epithelial cilium movement (GO:0003351)	2.73048720
47	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.69639088
48	indolalkylamine catabolic process (GO:0046218)	2.64230388
49	tryptophan catabolic process (GO:0006569)	2.64230388
50	indole-containing compound catabolic process (GO:0042436)	2.64230388
51	GTP biosynthetic process (GO:0006183)	2.62016651
52	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.61937925
53	regulation of cofactor metabolic process (GO:0051193)	2.60369320
54	regulation of coenzyme metabolic process (GO:0051196)	2.60369320
55	prenylation (GO:0097354)	2.58323389
56	protein prenylation (GO:0018342)	2.58323389
57	fusion of sperm to egg plasma membrane (GO:0007342)	2.57189741
58	regulation of synaptic transmission, dopaminergic (GO:0032225)	2.55944809
59	glycerophospholipid catabolic process (GO:0046475)	2.55771145
60	protein maturation by protein folding (GO:0022417)	2.55314632
61	DNA damage response, detection of DNA damage (GO:0042769)	2.54628041
62	behavioral response to cocaine (GO:0048148)	2.54032433
63	short-term memory (GO:0007614)	2.53655055
64	axoneme assembly (GO:0035082)	2.53646701
65	regulation of acyl-CoA biosynthetic process (GO:0050812)	2.53130021
66	organelle disassembly (GO:1903008)	2.52612392
67	positive regulation of fatty acid transport (GO:2000193)	2.51010566
68	ribonucleoprotein complex disassembly (GO:0032988)	2.50323473
69	negative regulation of viral genome replication (GO:0045071)	2.49957404
70	peristalsis (GO:0030432)	2.49733039
71	nonmotile primary cilium assembly (GO:0035058)	2.48858841
72	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.48596890
73	NADH dehydrogenase complex assembly (GO:0010257)	2.48596890
74	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.48596890
75	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.46565389
76	neurotransmitter-gated ion channel clustering (GO:0072578)	2.46146017
77	C-terminal protein lipidation (GO:0006501)	2.45665051
78	positive regulation of respiratory burst (GO:0060267)	2.45513353
79	kynurenine metabolic process (GO:0070189)	2.45233989
80	inner mitochondrial membrane organization (GO:0007007)	2.45039367
81	cellular ketone body metabolic process (GO:0046950)	2.42713376
82	activated T cell proliferation (GO:0050798)	2.41556314
83	mannosylation (GO:0097502)	2.40943571
84	muscle organ morphogenesis (GO:0048644)	2.40776439
85	positive regulation of defense response to virus by host (GO:0002230)	2.39174494
86	phasic smooth muscle contraction (GO:0014821)	2.38030182
87	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.37753684
88	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.36883143
89	regulation of mesoderm development (GO:2000380)	2.36522535
90	regulation of microtubule-based movement (GO:0060632)	2.36476000
91	neuronal action potential (GO:0019228)	2.35237185
92	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.32323903
93	branched-chain amino acid catabolic process (GO:0009083)	2.31686846
94	negative regulation of calcium ion transport into cytosol (GO:0010523)	2.31518200
95	negative regulation of telomere maintenance (GO:0032205)	2.31432665
96	pyrimidine-containing compound metabolic process (GO:0072527)	2.30344216
97	coenzyme A biosynthetic process (GO:0015937)	2.28598145
98	cytidine deamination (GO:0009972)	10.6405012
99	cytidine metabolic process (GO:0046087)	10.6405012
100	cytidine catabolic process (GO:0006216)	10.6405012

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	6.22036596
2	IGF1R_20145208_ChIP-Seq_DFB_Human	3.59882929
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.53628592
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.16263825
5	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.84723162
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.70003325
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.51534803
8	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.48143893
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.47672302
10	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.42295197
11	P300_19829295_ChIP-Seq_ESCs_Human	2.22634037
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.20134720
13	VDR_22108803_ChIP-Seq_LS180_Human	2.15957820
14	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.12086507
15	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.01312321
16	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.99811361
17	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.99313777
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.98121933
19	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.92006531
20	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.92006531
21	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.92006531
22	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.85974095
23	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.77745693
24	FUS_26573619_Chip-Seq_HEK293_Human	1.74826598
25	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.70451233
26	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.68216506
27	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.64481172
28	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.59367495
29	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.59367495
30	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.56226916
31	TP53_22573176_ChIP-Seq_HFKS_Human	1.54577430
32	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.53664174
33	CBP_20019798_ChIP-Seq_JUKART_Human	1.53664174
34	TAF15_26573619_Chip-Seq_HEK293_Human	1.53032912
35	MYC_18940864_ChIP-ChIP_HL60_Human	1.52802976
36	EWS_26573619_Chip-Seq_HEK293_Human	1.46169667
37	BCAT_22108803_ChIP-Seq_LS180_Human	1.45746749
38	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.39235005
39	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.39065828
40	TCF4_22108803_ChIP-Seq_LS180_Human	1.38902390
41	HTT_18923047_ChIP-ChIP_STHdh_Human	1.37599288
42	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.34594019
43	NCOR_22424771_ChIP-Seq_293T_Human	1.32977733
44	NANOG_19829295_ChIP-Seq_ESCs_Human	1.32289324
45	SOX2_19829295_ChIP-Seq_ESCs_Human	1.32289324
46	RNF2_27304074_Chip-Seq_NSC_Mouse	1.30633382
47	FOXP3_21729870_ChIP-Seq_TREG_Human	1.30240720
48	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.30100477
49	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.30017566
50	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.29074408
51	VDR_23849224_ChIP-Seq_CD4+_Human	1.25919888
52	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.24622651
53	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.24344916
54	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.23860500
55	ER_23166858_ChIP-Seq_MCF-7_Human	1.23727326
56	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.21827319
57	SMAD4_21799915_ChIP-Seq_A2780_Human	1.21582597
58	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.21413422
59	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.20800958
60	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.20279869
61	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.20029620
62	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.19758355
63	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.18612002
64	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.17810995
65	ELK1_19687146_ChIP-ChIP_HELA_Human	1.16316054
66	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.16208284
67	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.14995798
68	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.13845116
69	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.12397648
70	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.11594503
71	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.11143249
72	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.11131742
73	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.10380250
74	AR_25329375_ChIP-Seq_VCAP_Human	1.09827835
75	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.08585236
76	STAT3_23295773_ChIP-Seq_U87_Human	1.08164296
77	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.06924498
78	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.06011021
79	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	1.05228254
80	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.05077580
81	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.04091835
82	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.03838238
83	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.03070440
84	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.02996037
85	RUNX2_22187159_ChIP-Seq_PCA_Human	1.02859954
86	TCF4_23295773_ChIP-Seq_U87_Human	1.02387852
87	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.01777910
88	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.01393182
89	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.01309256
90	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.01006298
91	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.99722833
92	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.99620720
93	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.99314193
94	NANOG_20526341_ChIP-Seq_ESCs_Human	0.98362340
95	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.96501815
96	MYC_19829295_ChIP-Seq_ESCs_Human	0.96383068
97	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.95459442
98	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.95415252
99	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.93805436
100	AR_20517297_ChIP-Seq_VCAP_Human	0.92930003

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	3.96802783
2	MP0009379_abnormal_foot_pigmentation	3.78084046
3	MP0001529_abnormal_vocalization	3.13097475
4	MP0002736_abnormal_nociception_after	3.10459549
5	MP0001986_abnormal_taste_sensitivity	3.09500703
6	MP0008789_abnormal_olfactory_epithelium	3.01438738
7	MP0003890_abnormal_embryonic-extraembry	2.97448225
8	MP0003880_abnormal_central_pattern	2.96709969
9	MP0005499_abnormal_olfactory_system	2.91872213
10	MP0005394_taste/olfaction_phenotype	2.91872213
11	MP0004885_abnormal_endolymph	2.84108595
12	MP0001485_abnormal_pinna_reflex	2.72029731
13	MP0001968_abnormal_touch/_nociception	2.70506701
14	MP0005671_abnormal_response_to	2.49409362
15	MP0001984_abnormal_olfaction	2.44004327
16	MP0002102_abnormal_ear_morphology	2.42692922
17	MP0002234_abnormal_pharynx_morphology	2.26195676
18	MP0004142_abnormal_muscle_tone	2.15834742
19	MP0004133_heterotaxia	1.88316817
20	MP0003786_premature_aging	1.88237521
21	MP0005423_abnormal_somatic_nervous	1.85391333
22	MP0000049_abnormal_middle_ear	1.76538580
23	MP0003195_calcinosis	1.72716872
24	MP0005551_abnormal_eye_electrophysiolog	1.71503862
25	MP0001486_abnormal_startle_reflex	1.69768260
26	MP0004145_abnormal_muscle_electrophysio	1.68076428
27	MP0005377_hearing/vestibular/ear_phenot	1.59599823
28	MP0003878_abnormal_ear_physiology	1.59599823
29	MP0008877_abnormal_DNA_methylation	1.57101845
30	MP0003567_abnormal_fetal_cardiomyocyte	1.55437464
31	MP0002735_abnormal_chemical_nociception	1.50846949
32	MP0004043_abnormal_pH_regulation	1.38600620
33	MP0010030_abnormal_orbit_morphology	1.36765102
34	MP0002653_abnormal_ependyma_morphology	1.30090660
35	MP0005253_abnormal_eye_physiology	1.29028673
36	MP0003119_abnormal_digestive_system	1.27807504
37	MP0005386_behavior/neurological_phenoty	1.27732697
38	MP0004924_abnormal_behavior	1.27732697
39	MP0008058_abnormal_DNA_repair	1.27021673
40	MP0006072_abnormal_retinal_apoptosis	1.26957479
41	MP0004147_increased_porphyrin_level	1.25626985
42	MP0003718_maternal_effect	1.25219522
43	MP0009745_abnormal_behavioral_response	1.25176759
44	MP0002938_white_spotting	1.25160678
45	MP0009046_muscle_twitch	1.24073192
46	MP0000427_abnormal_hair_cycle	1.23491308
47	MP0003787_abnormal_imprinting	1.22540418
48	MP0010368_abnormal_lymphatic_system	1.22120242
49	MP0004742_abnormal_vestibular_system	1.20723854
50	MP0000631_abnormal_neuroendocrine_gland	1.20674626
51	MP0000566_synostosis	1.20113258
52	MP0005408_hypopigmentation	1.17819913
53	MP0002233_abnormal_nose_morphology	1.17817761
54	MP0002272_abnormal_nervous_system	1.07517077
55	MP0003137_abnormal_impulse_conducting	1.05697356
56	MP0008872_abnormal_physiological_respon	1.05160190
57	MP0002095_abnormal_skin_pigmentation	1.01975437
58	MP0001963_abnormal_hearing_physiology	0.99331286
59	MP0000516_abnormal_urinary_system	0.99149845
60	MP0005367_renal/urinary_system_phenotyp	0.99149845
61	MP0001293_anophthalmia	0.97950175
62	MP0000372_irregular_coat_pigmentation	0.97108076
63	MP0003879_abnormal_hair_cell	0.96208482
64	MP0000639_abnormal_adrenal_gland	0.92788454
65	MP0000749_muscle_degeneration	0.92645551
66	MP0003763_abnormal_thymus_physiology	0.91815683
67	MP0002067_abnormal_sensory_capabilities	0.91706458
68	MP0008007_abnormal_cellular_replicative	0.91048615
69	MP0005174_abnormal_tail_pigmentation	0.90286862
70	MP0002163_abnormal_gland_morphology	0.89198074
71	MP0008004_abnormal_stomach_pH	0.88500431
72	MP0003111_abnormal_nucleus_morphology	0.87609859
73	MP0009765_abnormal_xenobiotic_induced	0.87201416
74	MP0005451_abnormal_body_composition	0.84124744
75	MP0000026_abnormal_inner_ear	0.83106384
76	MP0002184_abnormal_innervation	0.80935759
77	MP0002734_abnormal_mechanical_nocicepti	0.78423544
78	MP0001764_abnormal_homeostasis	0.78139633
79	MP0005195_abnormal_posterior_eye	0.77761698
80	MP0005410_abnormal_fertilization	0.77619297
81	MP0004215_abnormal_myocardial_fiber	0.77503710
82	MP0004858_abnormal_nervous_system	0.75318254
83	MP0003693_abnormal_embryo_hatching	0.74566365
84	MP0003136_yellow_coat_color	0.73651009
85	MP0001188_hyperpigmentation	0.73480551
86	MP0003941_abnormal_skin_development	0.73296878
87	MP0002557_abnormal_social/conspecific_i	0.72956411
88	MP0000428_abnormal_craniofacial_morphol	0.72852397
89	MP0002876_abnormal_thyroid_physiology	0.71312940
90	MP0002572_abnormal_emotion/affect_behav	0.70499668
91	MP0008873_increased_physiological_sensi	0.70455964
92	MP0008932_abnormal_embryonic_tissue	0.69639762
93	MP0001970_abnormal_pain_threshold	0.69170651
94	MP0010329_abnormal_lipoprotein_level	0.67935926
95	MP0002752_abnormal_somatic_nervous	0.67442424
96	MP0005379_endocrine/exocrine_gland_phen	0.66104828
97	MP0005085_abnormal_gallbladder_physiolo	0.65490632
98	MP0005395_other_phenotype	0.64633864
99	MP0003937_abnormal_limbs/digits/tail_de	0.64446450
100	MP0003186_abnormal_redox_activity	0.64298545

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Aplastic anemia (HP:0001915)	5.90483403
2	Aplasia/Hypoplasia of the sacrum (HP:0008517)	4.10418101
3	T lymphocytopenia (HP:0005403)	3.76388328
4	Type II lissencephaly (HP:0007260)	3.40963568
5	Intestinal atresia (HP:0011100)	3.39176035
6	Carpal bone hypoplasia (HP:0001498)	3.38182433
7	Abnormality of abdominal situs (HP:0011620)	3.34444142
8	Abdominal situs inversus (HP:0003363)	3.34444142
9	Abnormality of T cell number (HP:0011839)	3.22221092
10	Oligodactyly (hands) (HP:0001180)	3.10423329
11	Chronic hepatic failure (HP:0100626)	3.09045115
12	Hyperglycinemia (HP:0002154)	3.08627462
13	Colon cancer (HP:0003003)	3.01814158
14	Congenital malformation of the right heart (HP:0011723)	2.84862015
15	Double outlet right ventricle (HP:0001719)	2.84862015
16	Pancreatic cysts (HP:0001737)	2.75468217
17	Abnormality of the pons (HP:0007361)	2.69546909
18	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.65698944
19	Progressive inability to walk (HP:0002505)	2.64798957
20	Hypoplasia of the pons (HP:0012110)	2.61600947
21	Abnormal respiratory motile cilium morphology (HP:0005938)	2.61583883
22	Abnormal respiratory epithelium morphology (HP:0012253)	2.61583883
23	Methylmalonic acidemia (HP:0002912)	2.60829312
24	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.54361527
25	Abnormality of the parathyroid morphology (HP:0011766)	2.52474812
26	Cerebellar dysplasia (HP:0007033)	2.51970809
27	Reticulocytopenia (HP:0001896)	2.45492420
28	Short tibia (HP:0005736)	2.44808947
29	Retinal dysplasia (HP:0007973)	2.42224032
30	Aplasia/hypoplasia of the uterus (HP:0008684)	2.39225106
31	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.38232252
32	Methylmalonic aciduria (HP:0012120)	2.37128289
33	Oligodactyly (HP:0012165)	2.35579997
34	Optic nerve hypoplasia (HP:0000609)	2.34329354
35	Abnormal rod and cone electroretinograms (HP:0008323)	2.33692803
36	Acute encephalopathy (HP:0006846)	2.32945095
37	Anterior segment dysgenesis (HP:0007700)	2.29382649
38	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.28685440
39	Combined immunodeficiency (HP:0005387)	2.25996922
40	Molar tooth sign on MRI (HP:0002419)	2.25042589
41	Abnormality of midbrain morphology (HP:0002418)	2.25042589
42	Absent radius (HP:0003974)	2.22729349
43	Acute necrotizing encephalopathy (HP:0006965)	2.22110826
44	Hepatoblastoma (HP:0002884)	2.18928973
45	Esophageal atresia (HP:0002032)	2.18754801
46	Sclerocornea (HP:0000647)	2.17807741
47	Horseshoe kidney (HP:0000085)	2.17420387
48	Deep palmar crease (HP:0006191)	2.13801488
49	Absent forearm bone (HP:0003953)	2.11995691
50	Aplasia involving forearm bones (HP:0009822)	2.11995691
51	Anencephaly (HP:0002323)	2.11455342
52	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.11106523
53	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	2.10572942
54	Bilateral microphthalmos (HP:0007633)	2.10249566
55	Aplasia/Hypoplasia of the macula (HP:0008059)	2.07357811
56	Bifid tongue (HP:0010297)	2.05774543
57	Severe combined immunodeficiency (HP:0004430)	2.05578690
58	Congenital stationary night blindness (HP:0007642)	2.04654986
59	Abnormality of T cells (HP:0002843)	2.01877764
60	Papilledema (HP:0001085)	2.01485930
61	Humeroradial synostosis (HP:0003041)	2.01074089
62	Synostosis involving the elbow (HP:0003938)	2.01074089
63	Mitochondrial inheritance (HP:0001427)	2.00916178
64	Hepatocellular necrosis (HP:0001404)	1.99793792
65	3-Methylglutaconic aciduria (HP:0003535)	1.99590243
66	True hermaphroditism (HP:0010459)	1.99011651
67	Abnormality of macular pigmentation (HP:0008002)	1.96473777
68	Aplasia/Hypoplasia affecting the retina (HP:0008061)	1.96167694
69	Microglossia (HP:0000171)	1.94540666
70	Anophthalmia (HP:0000528)	1.93399494
71	Septo-optic dysplasia (HP:0100842)	1.93303211
72	Disproportionate short-trunk short stature (HP:0003521)	1.93061155
73	11 pairs of ribs (HP:0000878)	1.92906379
74	Pancytopenia (HP:0001876)	1.92795476
75	Increased CSF lactate (HP:0002490)	1.91428619
76	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.89633702
77	Abnormal pancreas size (HP:0012094)	1.87600042
78	Fibular aplasia (HP:0002990)	1.87027359
79	Severe muscular hypotonia (HP:0006829)	1.86556803
80	Abnormality of alanine metabolism (HP:0010916)	1.85826524
81	Hyperalaninemia (HP:0003348)	1.85826524
82	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.85826524
83	Abnormality of urine glucose concentration (HP:0011016)	1.85255548
84	Glycosuria (HP:0003076)	1.85255548
85	Maternal diabetes (HP:0009800)	1.85247586
86	Aplasia/hypoplasia of the humerus (HP:0006507)	1.84842486
87	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.84246196
88	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.84246196
89	Hypoplasia of the uterus (HP:0000013)	1.83409241
90	Abolished electroretinogram (ERG) (HP:0000550)	1.81544985
91	Abnormal mitochondria in muscle tissue (HP:0008316)	1.81407455
92	Thrombocytosis (HP:0001894)	1.81214872
93	Gonadal dysgenesis (HP:0000133)	1.81113251
94	Aplasia/Hypoplasia of the ulna (HP:0006495)	1.80059020
95	Progressive macrocephaly (HP:0004481)	1.77521846
96	Nephronophthisis (HP:0000090)	1.77128871
97	Cellular immunodeficiency (HP:0005374)	1.76939914
98	Hypoplasia of the fovea (HP:0007750)	1.74966942
99	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.74966942
100	Inability to walk (HP:0002540)	1.74619274

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PDK2	5.19681530
2	STK16	4.51351182
3	MAP2K7	3.68737943
4	ERBB4	3.46904679
5	BUB1	3.31288201
6	MAP3K4	2.78809905
7	BCKDK	2.72392627
8	TXK	2.59904472
9	TAOK3	2.41796864
10	ADRBK2	2.25498481
11	CASK	2.21785682
12	ACVR1B	2.18629787
13	EIF2AK3	2.10123014
14	PLK4	2.05030497
15	EPHA4	1.99985278
16	WNK3	1.69885470
17	TRIM28	1.64484703
18	NEK6	1.48886711
19	ITK	1.45110717
20	PIK3CA	1.41578955
21	KDR	1.37708022
22	PBK	1.36980438
23	SRPK1	1.32755320
24	MAP3K6	1.28254816
25	BRSK2	1.26971846
26	STK38	1.26254382
27	PINK1	1.26099180
28	GRK1	1.21521238
29	NEK1	1.17410247
30	TNIK	1.16851866
31	FRK	1.13364825
32	PLK2	1.11650651
33	PAK3	1.08798996
34	MAPK13	1.07063145
35	BMPR1B	1.07033200
36	TNK2	1.06107643
37	ERBB3	1.02222839
38	CLK1	1.00163301
39	PLK3	0.98809321
40	WNK4	0.95795926
41	MAP4K2	0.95371693
42	OBSCN	0.87101066
43	PLK1	0.86358796
44	CDC7	0.85169064
45	ZAK	0.84996384
46	TESK2	0.84987971
47	TYRO3	0.83375468
48	NTRK2	0.81480764
49	PRKCG	0.81217309
50	MAPKAPK3	0.78965481
51	WEE1	0.76379105
52	STK4	0.74871462
53	CHEK2	0.71916279
54	GRK7	0.69682084
55	DYRK1B	0.69092385
56	CAMK1	0.66907876
57	FGFR1	0.65391989
58	AKT3	0.64752987
59	BRD4	0.64689704
60	TTK	0.63281726
61	VRK1	0.63047054
62	PTK2B	0.62725430
63	CSNK1A1L	0.61126479
64	MARK1	0.60284888
65	ADRBK1	0.59683132
66	PIM2	0.59679945
67	CSNK1G3	0.57710286
68	MAP3K5	0.55419763
69	MKNK2	0.55283735
70	CSNK1G1	0.53028806
71	INSRR	0.51361888
72	OXSR1	0.50010413
73	PRKCQ	0.48756081
74	LIMK1	0.47391646
75	STK39	0.46278517
76	PKN1	0.41814779
77	AURKA	0.41149945
78	CAMK2A	0.40062002
79	KIT	0.37027162
80	CSNK1A1	0.36844790
81	BCR	0.35812675
82	PRKCE	0.35382726
83	BRSK1	0.35354647
84	PRKCB	0.33920949
85	NME1	0.33791293
86	PRKACA	0.33621562
87	CDK7	0.29693156
88	DYRK2	0.28930731
89	MATK	0.27494772
90	MAP2K4	0.27492916
91	RPS6KB1	0.26887332
92	PRKCA	0.26798534
93	CSNK1G2	0.26522145
94	PAK1	0.26348326
95	CSNK2A2	0.25765946
96	TEC	0.25544614
97	CSNK2A1	0.25346763
98	ROCK1	0.24559814
99	INSR	0.23701656
100	CHEK1	0.23273485

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	3.21097907
2	RNA polymerase_Homo sapiens_hsa03020	2.86808496
3	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.79906089
4	Fatty acid elongation_Homo sapiens_hsa00062	2.67663699
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.64575601
6	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.59345413
7	Propanoate metabolism_Homo sapiens_hsa00640	2.56472657
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.51396666
9	Linoleic acid metabolism_Homo sapiens_hsa00591	2.44669798
10	Parkinsons disease_Homo sapiens_hsa05012	2.30891045
11	Proteasome_Homo sapiens_hsa03050	2.21639783
12	Oxidative phosphorylation_Homo sapiens_hsa00190	2.12494638
13	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.93130745
14	Caffeine metabolism_Homo sapiens_hsa00232	1.87975672
15	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.74054581
16	Pyrimidine metabolism_Homo sapiens_hsa00240	1.72664278
17	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.63400266
18	Ribosome_Homo sapiens_hsa03010	1.60545620
19	Base excision repair_Homo sapiens_hsa03410	1.60092844
20	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.58935671
21	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.54035719
22	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.51378199
23	Huntingtons disease_Homo sapiens_hsa05016	1.51277984
24	Butanoate metabolism_Homo sapiens_hsa00650	1.43439001
25	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.41449894
26	Peroxisome_Homo sapiens_hsa04146	1.36862360
27	Fanconi anemia pathway_Homo sapiens_hsa03460	1.33953003
28	Nicotine addiction_Homo sapiens_hsa05033	1.33429636
29	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.29241783
30	Alzheimers disease_Homo sapiens_hsa05010	1.25747666
31	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.20543864
32	Primary immunodeficiency_Homo sapiens_hsa05340	1.17577175
33	Sulfur metabolism_Homo sapiens_hsa00920	1.15932880
34	Phototransduction_Homo sapiens_hsa04744	1.15652039
35	Ether lipid metabolism_Homo sapiens_hsa00565	1.13996728
36	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.13577170
37	beta-Alanine metabolism_Homo sapiens_hsa00410	1.13006305
38	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.12787444
39	Homologous recombination_Homo sapiens_hsa03440	1.11447607
40	Fatty acid metabolism_Homo sapiens_hsa01212	1.11131700
41	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.08743690
42	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.08390196
43	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.06106374
44	Purine metabolism_Homo sapiens_hsa00230	1.04407728
45	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.03659054
46	Cardiac muscle contraction_Homo sapiens_hsa04260	1.02575737
47	Steroid biosynthesis_Homo sapiens_hsa00100	1.02185390
48	Retinol metabolism_Homo sapiens_hsa00830	0.97985899
49	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.97420848
50	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.96542899
51	Fat digestion and absorption_Homo sapiens_hsa04975	0.93903717
52	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.93104140
53	Olfactory transduction_Homo sapiens_hsa04740	0.90058564
54	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.88005458
55	Spliceosome_Homo sapiens_hsa03040	0.87375674
56	Antigen processing and presentation_Homo sapiens_hsa04612	0.87048720
57	Regulation of autophagy_Homo sapiens_hsa04140	0.86080008
58	Basal transcription factors_Homo sapiens_hsa03022	0.85611221
59	Galactose metabolism_Homo sapiens_hsa00052	0.82196529
60	Chemical carcinogenesis_Homo sapiens_hsa05204	0.81989215
61	Nitrogen metabolism_Homo sapiens_hsa00910	0.80722729
62	Tryptophan metabolism_Homo sapiens_hsa00380	0.78842955
63	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.77835095
64	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.76529881
65	Non-homologous end-joining_Homo sapiens_hsa03450	0.75808885
66	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.75205523
67	Wnt signaling pathway_Homo sapiens_hsa04310	0.72898719
68	RNA degradation_Homo sapiens_hsa03018	0.71894396
69	RNA transport_Homo sapiens_hsa03013	0.70924956
70	Metabolic pathways_Homo sapiens_hsa01100	0.69441791
71	Basal cell carcinoma_Homo sapiens_hsa05217	0.68010779
72	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.67989191
73	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.65808145
74	Morphine addiction_Homo sapiens_hsa05032	0.62415791
75	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.61799006
76	Serotonergic synapse_Homo sapiens_hsa04726	0.61362909
77	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.59276400
78	Arginine and proline metabolism_Homo sapiens_hsa00330	0.58780968
79	DNA replication_Homo sapiens_hsa03030	0.58755897
80	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.58367568
81	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.57755070
82	Mismatch repair_Homo sapiens_hsa03430	0.57680891
83	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.57367531
84	ABC transporters_Homo sapiens_hsa02010	0.56730052
85	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.51004518
86	Fatty acid degradation_Homo sapiens_hsa00071	0.50790081
87	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.46725865
88	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.44787383
89	Calcium signaling pathway_Homo sapiens_hsa04020	0.44434226
90	Circadian entrainment_Homo sapiens_hsa04713	0.43868445
91	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.43187795
92	Carbon metabolism_Homo sapiens_hsa01200	0.41794036
93	Pyruvate metabolism_Homo sapiens_hsa00620	0.41217963
94	Glutathione metabolism_Homo sapiens_hsa00480	0.41197153
95	Oocyte meiosis_Homo sapiens_hsa04114	0.39558923
96	Taste transduction_Homo sapiens_hsa04742	0.36288023
97	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.36205568
98	Nucleotide excision repair_Homo sapiens_hsa03420	0.34844537
99	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.34692730
100	Legionellosis_Homo sapiens_hsa05134	0.34285993

SNRPCP9

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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