SNRPD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a small nuclear ribonucleoprotein that belongs to the SNRNP core protein family. The protein may act as a charged protein scaffold to promote SNRNP assembly or strengthen SNRNP-SNRNP interactions through nonspecific electrostatic contacts with RNA. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)6.05590000
2ribosomal small subunit assembly (GO:0000028)6.01382175
3translational termination (GO:0006415)5.91986329
4ribosomal small subunit biogenesis (GO:0042274)5.68303492
5maturation of SSU-rRNA (GO:0030490)5.64235859
6translational elongation (GO:0006414)5.12683955
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.11048629
8chaperone-mediated protein transport (GO:0072321)5.09362163
9ribosomal large subunit biogenesis (GO:0042273)5.08127169
10cotranslational protein targeting to membrane (GO:0006613)5.02862805
11protein targeting to ER (GO:0045047)4.98996548
12translational initiation (GO:0006413)4.80193949
13nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.77612636
14establishment of protein localization to endoplasmic reticulum (GO:0072599)4.73771347
15cellular protein complex disassembly (GO:0043624)4.71839144
16protein localization to endoplasmic reticulum (GO:0070972)4.68463690
17viral life cycle (GO:0019058)4.63608487
18DNA strand elongation involved in DNA replication (GO:0006271)4.60940570
19telomere maintenance via semi-conservative replication (GO:0032201)4.58506487
20DNA strand elongation (GO:0022616)4.38733330
21mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.36462599
22DNA deamination (GO:0045006)4.35368422
23ribonucleoprotein complex biogenesis (GO:0022613)4.28671734
24DNA replication checkpoint (GO:0000076)4.23947451
25DNA replication initiation (GO:0006270)4.21722449
26protein complex disassembly (GO:0043241)4.19898011
27CENP-A containing nucleosome assembly (GO:0034080)4.19253590
28respiratory electron transport chain (GO:0022904)4.16650600
29telomere maintenance via recombination (GO:0000722)4.15265944
30chromatin remodeling at centromere (GO:0031055)4.13836335
31protein complex biogenesis (GO:0070271)4.11361728
32electron transport chain (GO:0022900)4.08969385
33mitochondrial respiratory chain complex assembly (GO:0033108)4.05075286
34proteasome assembly (GO:0043248)4.03160301
35kinetochore organization (GO:0051383)4.02387350
36macromolecular complex disassembly (GO:0032984)4.00361491
37translation (GO:0006412)3.96206682
38establishment of integrated proviral latency (GO:0075713)3.93116103
39mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.92989627
40mitochondrial respiratory chain complex I assembly (GO:0032981)3.92989627
41NADH dehydrogenase complex assembly (GO:0010257)3.92989627
42mitotic recombination (GO:0006312)3.92865610
43* spliceosomal snRNP assembly (GO:0000387)3.91363510
44formation of translation preinitiation complex (GO:0001731)3.91199288
45protein neddylation (GO:0045116)3.83804385
46regulation of mitochondrial translation (GO:0070129)3.83437078
47rRNA processing (GO:0006364)3.82463488
48kinetochore assembly (GO:0051382)3.80290221
49deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.75057488
50nuclear-transcribed mRNA catabolic process (GO:0000956)3.73046510
51DNA replication-independent nucleosome organization (GO:0034724)3.71042922
52DNA replication-independent nucleosome assembly (GO:0006336)3.71042922
53nucleotide-excision repair, DNA gap filling (GO:0006297)3.69820176
54rRNA metabolic process (GO:0016072)3.68994839
55mitotic metaphase plate congression (GO:0007080)3.68451438
56DNA unwinding involved in DNA replication (GO:0006268)3.65784687
57telomere maintenance via telomere lengthening (GO:0010833)3.62316259
58negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.59028336
59transcription elongation from RNA polymerase III promoter (GO:0006385)3.56213279
60termination of RNA polymerase III transcription (GO:0006386)3.56213279
61* spliceosomal complex assembly (GO:0000245)3.54939260
62pseudouridine synthesis (GO:0001522)3.54890917
63mRNA catabolic process (GO:0006402)3.53804548
64protein localization to kinetochore (GO:0034501)3.52561715
65cellular component biogenesis (GO:0044085)3.49976414
66ribosome biogenesis (GO:0042254)3.46988840
67viral mRNA export from host cell nucleus (GO:0046784)3.46793918
68transcription-coupled nucleotide-excision repair (GO:0006283)3.45889403
69regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.44964485
70regulation of mitotic spindle checkpoint (GO:1903504)3.44964485
71anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.42648789
72exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.40395632
73mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.40385733
74histone exchange (GO:0043486)3.39801064
75regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.39567260
76RNA catabolic process (GO:0006401)3.39562782
77nucleobase biosynthetic process (GO:0046112)3.38614735
78positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.37532044
79DNA replication-dependent nucleosome organization (GO:0034723)3.34321012
80DNA replication-dependent nucleosome assembly (GO:0006335)3.34321012
817-methylguanosine mRNA capping (GO:0006370)3.33636498
82RNA capping (GO:0036260)3.31779633
837-methylguanosine RNA capping (GO:0009452)3.31779633
84nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.29596030
85negative regulation of ligase activity (GO:0051352)3.28798763
86negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.28798763
87DNA damage response, detection of DNA damage (GO:0042769)3.27136666
88metaphase plate congression (GO:0051310)3.21122595
89respiratory chain complex IV assembly (GO:0008535)3.20976758
90protein targeting to membrane (GO:0006612)3.20797170
91protein targeting to mitochondrion (GO:0006626)3.19563913
92tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.17817586
93RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.17817586
94cytochrome complex assembly (GO:0017004)3.17724205
95purine nucleobase biosynthetic process (GO:0009113)3.16909911
96establishment of protein localization to mitochondrion (GO:0072655)3.16470577
97regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.16149685
98ATP synthesis coupled proton transport (GO:0015986)3.15097057
99energy coupled proton transport, down electrochemical gradient (GO:0015985)3.15097057
100inner mitochondrial membrane organization (GO:0007007)3.14849218
101water-soluble vitamin biosynthetic process (GO:0042364)3.14246828
102rRNA modification (GO:0000154)3.14087263
103intracellular protein transmembrane import (GO:0044743)3.13013972
104protein localization to mitochondrion (GO:0070585)3.12944788
105DNA double-strand break processing (GO:0000729)3.12495534
106protein localization to chromosome, centromeric region (GO:0071459)3.12416681
107cullin deneddylation (GO:0010388)3.11023447
108histone mRNA metabolic process (GO:0008334)3.07980839
109attachment of spindle microtubules to kinetochore (GO:0008608)3.07182470
110termination of RNA polymerase II transcription (GO:0006369)3.05781272
111DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.04369770
112negative regulation of DNA-dependent DNA replication (GO:2000104)3.02959466
113replication fork processing (GO:0031297)3.02504023
114establishment of viral latency (GO:0019043)3.02472396
115negative regulation of RNA splicing (GO:0033119)3.02246037
116ribosome assembly (GO:0042255)3.01737846
117protein deneddylation (GO:0000338)3.00774043
118G1/S transition of mitotic cell cycle (GO:0000082)3.00765660
119cell cycle G1/S phase transition (GO:0044843)3.00765660
120deoxyribonucleotide biosynthetic process (GO:0009263)2.99685232
121signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.99655864
122intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.99655864
123transcription elongation from RNA polymerase I promoter (GO:0006362)2.97987990
124establishment of protein localization to mitochondrial membrane (GO:0090151)2.97826730
125DNA-templated transcription, termination (GO:0006353)2.97522002
126ATP biosynthetic process (GO:0006754)2.97479056
127signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.97099583
128signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.97099583
129purine nucleoside triphosphate biosynthetic process (GO:0009145)2.90169960
130purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.89037097
131maturation of 5.8S rRNA (GO:0000460)2.88976236
132DNA ligation (GO:0006266)2.82334431
133regulation of helicase activity (GO:0051095)2.81885710

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.94934757
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.80931426
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.08609784
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.87268906
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.79689608
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.72962468
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.65650267
8FOXM1_23109430_ChIP-Seq_U2OS_Human3.45918830
9* ETS1_20019798_ChIP-Seq_JURKAT_Human3.33050887
10MYC_19079543_ChIP-ChIP_MESCs_Mouse3.29468917
11* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.28463052
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.22606622
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.20792443
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.15364402
15CREB1_15753290_ChIP-ChIP_HEK293T_Human3.15189281
16* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.12267697
17MYC_19030024_ChIP-ChIP_MESCs_Mouse3.05542347
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.78150903
19XRN2_22483619_ChIP-Seq_HELA_Human2.66914201
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.51455601
21* VDR_23849224_ChIP-Seq_CD4+_Human2.50875737
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.48053508
23* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.46505225
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.38471570
25DCP1A_22483619_ChIP-Seq_HELA_Human2.33985934
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.28535015
27TTF2_22483619_ChIP-Seq_HELA_Human2.27413552
28FOXP3_21729870_ChIP-Seq_TREG_Human2.18067514
29* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.17462409
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.15574860
31ELK1_19687146_ChIP-ChIP_HELA_Human2.10041377
32THAP11_20581084_ChIP-Seq_MESCs_Mouse2.08090705
33MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.05100573
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.03067206
35GABP_19822575_ChIP-Seq_HepG2_Human1.95679540
36AR_21909140_ChIP-Seq_LNCAP_Human1.91491060
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.90790888
38* E2F1_21310950_ChIP-Seq_MCF-7_Human1.84038860
39HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.79113987
40MYCN_18555785_ChIP-Seq_MESCs_Mouse1.78203519
41YY1_21170310_ChIP-Seq_MESCs_Mouse1.77614091
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.76314861
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.76029270
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75372397
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.75114110
46* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.73907552
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.71922597
48EWS_26573619_Chip-Seq_HEK293_Human1.61745610
49SRF_21415370_ChIP-Seq_HL-1_Mouse1.61383070
50TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.61271578
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.60358854
52NANOG_18555785_ChIP-Seq_MESCs_Mouse1.53723146
53* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.49536110
54FUS_26573619_Chip-Seq_HEK293_Human1.49390736
55ZNF274_21170338_ChIP-Seq_K562_Hela1.48817668
56VDR_22108803_ChIP-Seq_LS180_Human1.46842671
57POU5F1_16153702_ChIP-ChIP_HESCs_Human1.45956237
58CIITA_25753668_ChIP-Seq_RAJI_Human1.42096175
59MYC_18940864_ChIP-ChIP_HL60_Human1.42054580
60POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.41785527
61RBPJ_22232070_ChIP-Seq_NCS_Mouse1.39725323
62TP63_19390658_ChIP-ChIP_HaCaT_Human1.33986590
63* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.33677835
64PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.31380078
65* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.29590693
66KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.29059629
67SALL1_21062744_ChIP-ChIP_HESCs_Human1.28610174
68KDM5A_27292631_Chip-Seq_BREAST_Human1.28026937
69PADI4_21655091_ChIP-ChIP_MCF-7_Human1.26609601
70CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25804371
71ERG_20887958_ChIP-Seq_HPC-7_Mouse1.25062725
72SOX2_18555785_ChIP-Seq_MESCs_Mouse1.23753481
73ELK1_22589737_ChIP-Seq_MCF10A_Human1.22282249
74CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.18312066
75* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.16505768
76ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.13605905
77FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.07146055
78E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06891676
79CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05908883
80TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.05366748
81CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05149248
82NOTCH1_21737748_ChIP-Seq_TLL_Human1.01576096
83FLI1_27457419_Chip-Seq_LIVER_Mouse0.99899827
84BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.98423558
85CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.96302720
86GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.95000882
87* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.90231658
88HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.89275366
89MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.88518416
90SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.88277423
91KLF4_18555785_ChIP-Seq_MESCs_Mouse0.87947166
92GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86226013
93ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.85997191
94STAT3_1855785_ChIP-Seq_MESCs_Mouse0.85752369
95DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.82725471
96CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.82340757
97TFEB_21752829_ChIP-Seq_HELA_Human0.82030112
98EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.79866076
99MYC_22102868_ChIP-Seq_BL_Human0.78774380
100GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.78475370
101NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.78322250
102SPI1_23547873_ChIP-Seq_NB4_Human0.78067218
103TAF15_26573619_Chip-Seq_HEK293_Human0.77884897
104IRF1_19129219_ChIP-ChIP_H3396_Human0.77611085
105POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.76377976
106SOX17_20123909_ChIP-Seq_XEN_Mouse0.76199614
107OCT4_18692474_ChIP-Seq_MEFs_Mouse0.74435660
108HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.74318219
109CTBP1_25329375_ChIP-Seq_LNCAP_Human0.73519395
110P300_19829295_ChIP-Seq_ESCs_Human0.73356129
111* TP53_22573176_ChIP-Seq_HFKS_Human0.72465830
112SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.72343485
113NANOG_16153702_ChIP-ChIP_HESCs_Human0.71736417
114EGR1_19374776_ChIP-ChIP_THP-1_Human0.71572719
115* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71558628
116SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.70555449
117SOX2_18692474_ChIP-Seq_MEFs_Mouse0.70413361
118PCGF2_27294783_Chip-Seq_ESCs_Mouse0.70260998
119SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.70121395
120KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.69760086
121SOX2_16153702_ChIP-ChIP_HESCs_Human0.69678370
122NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.69420278
123IGF1R_20145208_ChIP-Seq_DFB_Human0.68564693
124CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.66409537

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.53236759
2MP0004957_abnormal_blastocyst_morpholog4.55287472
3MP0010094_abnormal_chromosome_stability4.46255523
4MP0003111_abnormal_nucleus_morphology4.05726026
5MP0003077_abnormal_cell_cycle3.92378004
6MP0008057_abnormal_DNA_replication3.72684941
7MP0008058_abnormal_DNA_repair3.52501052
8MP0009379_abnormal_foot_pigmentation3.43058950
9MP0008932_abnormal_embryonic_tissue3.15876308
10MP0008007_abnormal_cellular_replicative2.79556122
11MP0002837_dystrophic_cardiac_calcinosis2.59930016
12MP0003123_paternal_imprinting2.51937051
13MP0003646_muscle_fatigue2.26750014
14MP0003786_premature_aging2.06577970
15MP0000350_abnormal_cell_proliferation1.98880231
16MP0006292_abnormal_olfactory_placode1.98866997
17MP0008877_abnormal_DNA_methylation1.95316136
18MP0002396_abnormal_hematopoietic_system1.88214811
19MP0001730_embryonic_growth_arrest1.87313554
20MP0003315_abnormal_perineum_morphology1.83247778
21MP0003718_maternal_effect1.77428629
22MP0002102_abnormal_ear_morphology1.63415396
23MP0010030_abnormal_orbit_morphology1.59969365
24MP0000490_abnormal_crypts_of1.54088926
25MP0001697_abnormal_embryo_size1.52217055
26MP0001485_abnormal_pinna_reflex1.50924268
27MP0002736_abnormal_nociception_after1.47211755
28MP0003806_abnormal_nucleotide_metabolis1.42288544
29MP0003121_genomic_imprinting1.41365575
30MP0000313_abnormal_cell_death1.38739513
31MP0000631_abnormal_neuroendocrine_gland1.37781071
32MP0001529_abnormal_vocalization1.33706849
33MP0003567_abnormal_fetal_cardiomyocyte1.33551431
34MP0003136_yellow_coat_color1.33268223
35MP0001672_abnormal_embryogenesis/_devel1.32705905
36MP0005380_embryogenesis_phenotype1.32705905
37MP0002080_prenatal_lethality1.32105314
38MP0002085_abnormal_embryonic_tissue1.31840800
39MP0000049_abnormal_middle_ear1.29879967
40MP0002938_white_spotting1.28716211
41MP0002234_abnormal_pharynx_morphology1.27864992
42MP0008995_early_reproductive_senescence1.27463598
43MP0008789_abnormal_olfactory_epithelium1.24059557
44MP0009333_abnormal_splenocyte_physiolog1.22919254
45MP0002210_abnormal_sex_determination1.21458115
46MP0002132_abnormal_respiratory_system1.17799241
47MP0002019_abnormal_tumor_incidence1.16181304
48MP0001293_anophthalmia1.12092486
49MP0004142_abnormal_muscle_tone1.11959330
50MP0003984_embryonic_growth_retardation1.11826759
51MP0002751_abnormal_autonomic_nervous1.11770557
52MP0003011_delayed_dark_adaptation1.10477980
53MP0002088_abnormal_embryonic_growth/wei1.09018585
54MP0001188_hyperpigmentation1.08951801
55MP0002084_abnormal_developmental_patter1.08736084
56MP0004147_increased_porphyrin_level1.08225521
57MP0000537_abnormal_urethra_morphology1.07394356
58MP0004133_heterotaxia1.05388422
59MP0004808_abnormal_hematopoietic_stem1.03050151
60MP0003890_abnormal_embryonic-extraembry1.02835088
61MP0001145_abnormal_male_reproductive1.02170809
62MP0003937_abnormal_limbs/digits/tail_de1.01795934
63MP0002160_abnormal_reproductive_system1.01415291
64MP0009053_abnormal_anal_canal1.01338237
65MP0005084_abnormal_gallbladder_morpholo0.98136277
66MP0004197_abnormal_fetal_growth/weight/0.97316317
67MP0003186_abnormal_redox_activity0.96876818
68MP0002233_abnormal_nose_morphology0.96523352
69MP0002163_abnormal_gland_morphology0.95480128
70MP0002697_abnormal_eye_size0.91488662
71MP0006035_abnormal_mitochondrial_morpho0.91327855
72MP0000703_abnormal_thymus_morphology0.91273821
73MP0005174_abnormal_tail_pigmentation0.90644443
74MP0005253_abnormal_eye_physiology0.90537445
75MP0000653_abnormal_sex_gland0.89986050
76MP0001968_abnormal_touch/_nociception0.89964190
77MP0005551_abnormal_eye_electrophysiolog0.89811446
78MP0005646_abnormal_pituitary_gland0.89481216
79MP0003119_abnormal_digestive_system0.88707475
80MP0003941_abnormal_skin_development0.88260322
81MP0002086_abnormal_extraembryonic_tissu0.88141870
82MP0001286_abnormal_eye_development0.88136937
83MP0008872_abnormal_physiological_respon0.87971496
84MP0003938_abnormal_ear_development0.87378620
85MP0002095_abnormal_skin_pigmentation0.86062819
86MP0002638_abnormal_pupillary_reflex0.85900902
87MP0000566_synostosis0.84874179
88MP0001929_abnormal_gametogenesis0.84508880
89MP0006054_spinal_hemorrhage0.84439498
90MP0002282_abnormal_trachea_morphology0.83243739
91MP0000358_abnormal_cell_content/0.82948442
92MP0005389_reproductive_system_phenotype0.82798500
93MP0003763_abnormal_thymus_physiology0.82271627
94MP0001119_abnormal_female_reproductive0.81723336
95MP0001986_abnormal_taste_sensitivity0.80928579
96MP0005391_vision/eye_phenotype0.79795030
97MP0006036_abnormal_mitochondrial_physio0.79043668
98MP0010307_abnormal_tumor_latency0.77455597
99MP0002111_abnormal_tail_morphology0.77403220
100MP0010352_gastrointestinal_tract_polyps0.76893763
101MP0005499_abnormal_olfactory_system0.76759437
102MP0005394_taste/olfaction_phenotype0.76759437
103MP0002398_abnormal_bone_marrow0.75732088
104MP0002277_abnormal_respiratory_mucosa0.75264655
105MP0003122_maternal_imprinting0.75079147
106MP0006072_abnormal_retinal_apoptosis0.75002356
107MP0003755_abnormal_palate_morphology0.73752490
108MP0001984_abnormal_olfaction0.73058174
109MP0002722_abnormal_immune_system0.72914176
110MP0000858_altered_metastatic_potential0.72907214
111MP0003195_calcinosis0.72592069
112MP0000372_irregular_coat_pigmentation0.72127202
113MP0004145_abnormal_muscle_electrophysio0.71905180
114MP0002653_abnormal_ependyma_morphology0.70444388
115MP0009046_muscle_twitch0.69850840
116MP0005408_hypopigmentation0.69716035
117MP0005397_hematopoietic_system_phenotyp0.69530300
118MP0001545_abnormal_hematopoietic_system0.69530300
119MP0003698_abnormal_male_reproductive0.69174267
120MP0005195_abnormal_posterior_eye0.68100194
121MP0003861_abnormal_nervous_system0.67330646
122MP0001727_abnormal_embryo_implantation0.66770255
123MP0001919_abnormal_reproductive_system0.66637312
124MP0005075_abnormal_melanosome_morpholog0.66621947
125MP0004742_abnormal_vestibular_system0.65593033
126MP0000689_abnormal_spleen_morphology0.64186729
127MP0009250_abnormal_appendicular_skeleto0.63398471
128MP0003385_abnormal_body_wall0.62187787
129MP0003942_abnormal_urinary_system0.61745892
130MP0009697_abnormal_copulation0.61587238
131MP0002249_abnormal_larynx_morphology0.60713591

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)6.20079468
2Reticulocytopenia (HP:0001896)5.95379151
3Abnormal number of erythroid precursors (HP:0012131)5.77229492
4Birth length less than 3rd percentile (HP:0003561)4.33503647
5Macrocytic anemia (HP:0001972)4.32450280
6Pallor (HP:0000980)4.14498360
7Breast hypoplasia (HP:0003187)3.70868011
8Acute necrotizing encephalopathy (HP:0006965)3.60067573
9Oral leukoplakia (HP:0002745)3.56126036
10Aplastic anemia (HP:0001915)3.53722870
11Mitochondrial inheritance (HP:0001427)3.33155632
12Abnormal mitochondria in muscle tissue (HP:0008316)3.29523555
13Patellar aplasia (HP:0006443)3.24735081
14Increased hepatocellular lipid droplets (HP:0006565)3.20921499
15Aplasia/Hypoplasia of the patella (HP:0006498)3.11884002
16Colon cancer (HP:0003003)3.10170556
17Septo-optic dysplasia (HP:0100842)3.02360748
18Chromsome breakage (HP:0040012)3.01855229
19Cerebral edema (HP:0002181)3.01582224
20Aplasia/Hypoplasia of the sacrum (HP:0008517)3.00364318
21Increased CSF lactate (HP:0002490)2.97837280
22Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.95735553
23Decreased activity of mitochondrial respiratory chain (HP:0008972)2.95735553
24Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.89180489
25Hepatocellular necrosis (HP:0001404)2.88164757
26Progressive macrocephaly (HP:0004481)2.86373973
27Chromosomal breakage induced by crosslinking agents (HP:0003221)2.83603975
28Meckel diverticulum (HP:0002245)2.80988775
29Abnormality of the preputium (HP:0100587)2.80414488
30Rough bone trabeculation (HP:0100670)2.75402755
31Carpal bone hypoplasia (HP:0001498)2.68035199
32Abnormality of the ileum (HP:0001549)2.65399357
33Degeneration of anterior horn cells (HP:0002398)2.64332917
34Abnormality of the anterior horn cell (HP:0006802)2.64332917
35Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.63344247
36Acute encephalopathy (HP:0006846)2.62163870
37Lipid accumulation in hepatocytes (HP:0006561)2.61772999
38Methylmalonic acidemia (HP:0002912)2.61406332
39Absent thumb (HP:0009777)2.60548884
40Abnormality of chromosome stability (HP:0003220)2.57136479
41Horseshoe kidney (HP:0000085)2.56275836
42Pancreatic fibrosis (HP:0100732)2.55025410
43Exertional dyspnea (HP:0002875)2.54766944
4411 pairs of ribs (HP:0000878)2.50345393
45Triphalangeal thumb (HP:0001199)2.49121989
46True hermaphroditism (HP:0010459)2.48590203
47Selective tooth agenesis (HP:0001592)2.46277812
48Cerebral hypomyelination (HP:0006808)2.45931038
49Increased serum lactate (HP:0002151)2.45221206
50Abnormality of midbrain morphology (HP:0002418)2.39105419
51Molar tooth sign on MRI (HP:0002419)2.39105419
52Abnormal number of incisors (HP:0011064)2.38299798
53Absent radius (HP:0003974)2.38240529
54Pendular nystagmus (HP:0012043)2.37710895
55Premature graying of hair (HP:0002216)2.36430476
56Abnormal lung lobation (HP:0002101)2.34916083
57Lactic acidosis (HP:0003128)2.34047010
58Cleft eyelid (HP:0000625)2.33591944
593-Methylglutaconic aciduria (HP:0003535)2.32248552
60Leukodystrophy (HP:0002415)2.32196451
61Aplasia/Hypoplasia of the uvula (HP:0010293)2.29156217
62Methylmalonic aciduria (HP:0012120)2.27145626
63Absent forearm bone (HP:0003953)2.25222975
64Aplasia involving forearm bones (HP:0009822)2.25222975
65Supernumerary spleens (HP:0009799)2.25166843
66Hepatic necrosis (HP:0002605)2.24296405
67Microretrognathia (HP:0000308)2.23176688
68Exercise intolerance (HP:0003546)2.22943091
69Medulloblastoma (HP:0002885)2.21811104
70Myelodysplasia (HP:0002863)2.20175450
71Small intestinal stenosis (HP:0012848)2.17743661
72Duodenal stenosis (HP:0100867)2.17743661
73Hyperglycinemia (HP:0002154)2.15056627
74Respiratory difficulties (HP:0002880)2.14373431
75Abnormality of alanine metabolism (HP:0010916)2.13259097
76Hyperalaninemia (HP:0003348)2.13259097
77Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.13259097
78Renal Fanconi syndrome (HP:0001994)2.12808949
79Increased intramyocellular lipid droplets (HP:0012240)2.11220106
80Trismus (HP:0000211)2.10225608
81Atresia of the external auditory canal (HP:0000413)2.09138006
82Depressed nasal ridge (HP:0000457)2.08788224
83Abnormality of methionine metabolism (HP:0010901)2.07063764
84Absent septum pellucidum (HP:0001331)2.06605741
85Nephronophthisis (HP:0000090)2.06188075
86Multiple enchondromatosis (HP:0005701)2.05921335
87Increased serum pyruvate (HP:0003542)2.05187975
88Abnormality of glycolysis (HP:0004366)2.05187975
89Sclerocornea (HP:0000647)2.04399811
90Cellular immunodeficiency (HP:0005374)2.02786329
91Abnormal trabecular bone morphology (HP:0100671)2.02566818
92Pancytopenia (HP:0001876)2.01355817
93Abnormality of serum amino acid levels (HP:0003112)2.01115355
94Abnormality of renal resorption (HP:0011038)2.01079173
95Bone marrow hypocellularity (HP:0005528)1.99809959
96Tracheoesophageal fistula (HP:0002575)1.99461775
97Abnormality of reticulocytes (HP:0004312)1.98995530
98Abnormality of the heme biosynthetic pathway (HP:0010472)1.98982185
99Neoplasm of the pancreas (HP:0002894)1.98800997
100Glossoptosis (HP:0000162)1.98722370
101Type I transferrin isoform profile (HP:0003642)1.98659164
102Hypoplasia of the pons (HP:0012110)1.98433674
103Secondary amenorrhea (HP:0000869)1.96222744
104Congenital, generalized hypertrichosis (HP:0004540)1.95676713
105Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.95652374
106Abnormality of homocysteine metabolism (HP:0010919)1.93483496
107Homocystinuria (HP:0002156)1.93483496
108Abnormality of the pons (HP:0007361)1.92873171
109Microvesicular hepatic steatosis (HP:0001414)1.92203993
110Increased muscle lipid content (HP:0009058)1.92015329
111Respiratory failure (HP:0002878)1.91502951
112Lethargy (HP:0001254)1.89324232
113Megaloblastic anemia (HP:0001889)1.87055038
114Abnormality of the labia minora (HP:0012880)1.86385661
115Hypoplasia of the radius (HP:0002984)1.85260893
116Maternal diabetes (HP:0009800)1.85118990
117Irregular epiphyses (HP:0010582)1.84003263
118Abnormality of the septum pellucidum (HP:0007375)1.83679462
119Abnormality of aspartate family amino acid metabolism (HP:0010899)1.83402462
120Ectopic kidney (HP:0000086)1.82627840
121Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.82475168
122Anophthalmia (HP:0000528)1.82166370
123Agnosia (HP:0010524)1.81023188
124Bilateral microphthalmos (HP:0007633)1.80855952
125Pancreatic cysts (HP:0001737)1.80492014
126Thrombocytosis (HP:0001894)1.80326850
127Duplicated collecting system (HP:0000081)1.80092343
128Muscle fiber atrophy (HP:0100295)1.79837376
129Optic nerve hypoplasia (HP:0000609)1.79120526
130Abnormality of the duodenum (HP:0002246)1.78866980
131Sloping forehead (HP:0000340)1.77297422
132Stenosis of the external auditory canal (HP:0000402)1.76567307
133Impulsivity (HP:0100710)1.76294414
134Optic disc pallor (HP:0000543)1.75487089
135Premature ovarian failure (HP:0008209)1.75195261
136Short thumb (HP:0009778)1.75002191
137Facial cleft (HP:0002006)1.74734710
138Anencephaly (HP:0002323)1.73349117
139Abnormality of the carotid arteries (HP:0005344)1.67863151

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.48213610
2BUB14.47824344
3WEE14.12621237
4EIF2AK13.97687984
5TLK13.54926529
6CDC73.52447441
7SRPK13.44598242
8NME23.39791853
9STK163.19541144
10VRK12.63908203
11MKNK12.55709948
12EIF2AK32.28130052
13TAF12.24094198
14PLK42.20681241
15NUAK12.17821685
16MKNK22.17488781
17BRSK21.87724476
18NEK21.86954852
19PLK11.81348731
20NME11.78543090
21TTK1.77193972
22ACVR1B1.74751365
23DYRK31.70689278
24TSSK61.67055622
25WNK31.65074821
26NEK11.62445806
27AURKB1.60967530
28TESK21.54815734
29CDK71.51992242
30PBK1.51086519
31CCNB11.50172909
32PLK31.43323817
33AURKA1.36220500
34ATR1.33838059
35RPS6KB21.32490684
36CDK81.31985821
37TRIM281.30312833
38BRSK11.26216610
39CHEK21.24449705
40EIF2AK21.17052190
41RPS6KA41.16713466
42CDK191.09039141
43PASK1.08983832
44PIM21.08502925
45ADRBK21.05144357
46GRK11.04753459
47TGFBR10.97769021
48MAP3K80.92701685
49FRK0.91350856
50CHEK10.89555028
51DYRK20.88276563
52ZAK0.85528920
53CSNK2A10.84911243
54MST40.82656420
55WNK40.82616157
56CSNK2A20.81059810
57TESK10.80495765
58PDK20.79319082
59PNCK0.78969294
60BRAF0.78913552
61INSRR0.78149457
62MAP4K20.77003408
63KDR0.76286038
64PAK40.76276847
65LIMK10.75770552
66CDK40.75285000
67CSNK1G10.69671204
68ATM0.67961273
69PAK10.65640563
70LRRK20.65503860
71ILK0.65085461
72OXSR10.63764926
73IRAK40.63544645
74CDK20.63532916
75STK40.63468043
76MAP3K110.63454342
77STK30.63101819
78CDK30.59987013
79CLK10.59897533
80YES10.59662756
81PRKCG0.59027098
82RPS6KA50.58446013
83ALK0.56798769
84CSNK1G20.55589653
85STK100.53375392
86ABL20.53318411
87CDK10.51895030
88SCYL20.51005269
89BCKDK0.49773684
90PIM10.49270188
91MAP3K40.47211799
92MAPKAPK50.45060459
93PINK10.43599176
94MAP3K90.43337217
95BMPR1B0.41075822
96STK390.40377562
97UHMK10.39447207
98PRKCI0.38460163
99STK38L0.38101271
100TEC0.36915324
101MAP2K70.35691263
102EPHB20.35266330
103CSNK1A10.34490436
104CSNK1A1L0.34048457
105TIE10.33588780
106CASK0.30476486
107CDK11A0.30235061
108CSNK1E0.28710600
109CSNK1G30.28437194
110FGFR10.27916168
111STK240.27355064
112TAOK20.27153238
113BTK0.26490184
114MAP3K120.26267197
115ERBB30.26142166
116LYN0.24464412
117MELK0.23946080
118EPHA20.23300248
119CDK140.23105384
120AKT20.22990281
121MAP3K100.22971268
122PRKDC0.22787011
123CDK180.22763472
124ERBB40.22036715
125ADRBK10.22010979
126DAPK10.21580092
127CDK150.21254517
128TNIK0.20252749
129PRKACB0.19536869
130DAPK30.19407358
131BLK0.19400924
132PRKACA0.18557119
133BCR0.16513877
134BRD40.16496416
135MAPK130.15250882
136MAPKAPK30.13792727
137PLK20.13608048

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.42780791
2DNA replication_Homo sapiens_hsa030304.72219348
3Mismatch repair_Homo sapiens_hsa034303.94099285
4Proteasome_Homo sapiens_hsa030503.91800587
5RNA polymerase_Homo sapiens_hsa030203.74843461
6* Spliceosome_Homo sapiens_hsa030403.48170067
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.27759000
8Homologous recombination_Homo sapiens_hsa034403.09467961
9Nucleotide excision repair_Homo sapiens_hsa034202.82646701
10Base excision repair_Homo sapiens_hsa034102.79576424
11RNA transport_Homo sapiens_hsa030132.74064371
12Pyrimidine metabolism_Homo sapiens_hsa002402.71753575
13Cell cycle_Homo sapiens_hsa041102.31295600
14Fanconi anemia pathway_Homo sapiens_hsa034602.16988134
15Oxidative phosphorylation_Homo sapiens_hsa001902.09172358
16Parkinsons disease_Homo sapiens_hsa050122.07540632
17One carbon pool by folate_Homo sapiens_hsa006701.98542442
18Basal transcription factors_Homo sapiens_hsa030221.95259096
19RNA degradation_Homo sapiens_hsa030181.91153186
20Non-homologous end-joining_Homo sapiens_hsa034501.84370011
21Huntingtons disease_Homo sapiens_hsa050161.79544749
22Protein export_Homo sapiens_hsa030601.73483203
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.73429591
24mRNA surveillance pathway_Homo sapiens_hsa030151.50103245
25Purine metabolism_Homo sapiens_hsa002301.46487857
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.30399101
27p53 signaling pathway_Homo sapiens_hsa041151.25236893
28Alzheimers disease_Homo sapiens_hsa050101.23861361
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.20739607
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.16145072
31Pyruvate metabolism_Homo sapiens_hsa006201.09779477
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.09553505
33Epstein-Barr virus infection_Homo sapiens_hsa051691.06724435
34Propanoate metabolism_Homo sapiens_hsa006401.03598049
35* Systemic lupus erythematosus_Homo sapiens_hsa053221.02013297
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.92286567
37Oocyte meiosis_Homo sapiens_hsa041140.83730417
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72918846
39Sulfur relay system_Homo sapiens_hsa041220.72841771
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.71227897
41Steroid biosynthesis_Homo sapiens_hsa001000.70642838
42Herpes simplex infection_Homo sapiens_hsa051680.69398068
43Fatty acid elongation_Homo sapiens_hsa000620.64252287
44Vitamin B6 metabolism_Homo sapiens_hsa007500.62862035
45Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62583756
46Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62499899
47Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60890611
48Butanoate metabolism_Homo sapiens_hsa006500.58815266
49Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.58716893
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.58650483
51Folate biosynthesis_Homo sapiens_hsa007900.58320854
52Nitrogen metabolism_Homo sapiens_hsa009100.58282252
53Vitamin digestion and absorption_Homo sapiens_hsa049770.58237910
54Viral carcinogenesis_Homo sapiens_hsa052030.58063833
55Antigen processing and presentation_Homo sapiens_hsa046120.57478766
56Cardiac muscle contraction_Homo sapiens_hsa042600.55820277
57Caffeine metabolism_Homo sapiens_hsa002320.54946897
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54243870
59HTLV-I infection_Homo sapiens_hsa051660.51332917
60Alcoholism_Homo sapiens_hsa050340.51210041
61Tryptophan metabolism_Homo sapiens_hsa003800.50805188
62Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.50721010
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.50472365
64Pentose phosphate pathway_Homo sapiens_hsa000300.50458620
65Peroxisome_Homo sapiens_hsa041460.49254541
66Nicotine addiction_Homo sapiens_hsa050330.47678501
67Glutathione metabolism_Homo sapiens_hsa004800.47637165
68Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45965986
69Thyroid cancer_Homo sapiens_hsa052160.44989716
70Maturity onset diabetes of the young_Homo sapiens_hsa049500.44920414
71Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44815157
72Linoleic acid metabolism_Homo sapiens_hsa005910.43958636
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43846960
74Phototransduction_Homo sapiens_hsa047440.43382419
75Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43154094
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40275503
77Chemical carcinogenesis_Homo sapiens_hsa052040.39464266
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.39190281
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38850102
80Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37838222
81N-Glycan biosynthesis_Homo sapiens_hsa005100.37780312
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37175694
832-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.36661573
84Sulfur metabolism_Homo sapiens_hsa009200.36269345
85Metabolic pathways_Homo sapiens_hsa011000.33762670
86Retinol metabolism_Homo sapiens_hsa008300.33139776
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.32798689
88Basal cell carcinoma_Homo sapiens_hsa052170.32485656
89Olfactory transduction_Homo sapiens_hsa047400.31767286
90Legionellosis_Homo sapiens_hsa051340.30998852
91Primary immunodeficiency_Homo sapiens_hsa053400.29925653
92MicroRNAs in cancer_Homo sapiens_hsa052060.28747043
93Asthma_Homo sapiens_hsa053100.28430028
94beta-Alanine metabolism_Homo sapiens_hsa004100.28216898
95Arginine and proline metabolism_Homo sapiens_hsa003300.28186433
96Transcriptional misregulation in cancer_Homo sapiens_hsa052020.28076478
97TGF-beta signaling pathway_Homo sapiens_hsa043500.28014394
98Cyanoamino acid metabolism_Homo sapiens_hsa004600.27526679
99Arachidonic acid metabolism_Homo sapiens_hsa005900.26925115
100Collecting duct acid secretion_Homo sapiens_hsa049660.24731990
101Biosynthesis of amino acids_Homo sapiens_hsa012300.24353104
102Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.23896028
103Taste transduction_Homo sapiens_hsa047420.23568063
104alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.23259118
105Small cell lung cancer_Homo sapiens_hsa052220.21378859
106Fat digestion and absorption_Homo sapiens_hsa049750.20573508
107Fatty acid degradation_Homo sapiens_hsa000710.20509694
108Allograft rejection_Homo sapiens_hsa053300.20501516
109Apoptosis_Homo sapiens_hsa042100.19666727
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.19591120
111SNARE interactions in vesicular transport_Homo sapiens_hsa041300.18252807
112Hippo signaling pathway_Homo sapiens_hsa043900.17567896
113Hematopoietic cell lineage_Homo sapiens_hsa046400.17521323
114Ether lipid metabolism_Homo sapiens_hsa005650.16664912
115Steroid hormone biosynthesis_Homo sapiens_hsa001400.16525054
116Hepatitis B_Homo sapiens_hsa051610.16480220
117Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.16338311
118Colorectal cancer_Homo sapiens_hsa052100.16321324
119Regulation of autophagy_Homo sapiens_hsa041400.15698548
120Shigellosis_Homo sapiens_hsa051310.15455008
121Measles_Homo sapiens_hsa051620.14915932
122Hedgehog signaling pathway_Homo sapiens_hsa043400.14599208
123Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.13693458
124Intestinal immune network for IgA production_Homo sapiens_hsa046720.13673074
125Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.13316783
126Wnt signaling pathway_Homo sapiens_hsa043100.11918818
127Autoimmune thyroid disease_Homo sapiens_hsa053200.11154898
128Graft-versus-host disease_Homo sapiens_hsa053320.10906385
129Pathways in cancer_Homo sapiens_hsa052000.10766903
130Renin-angiotensin system_Homo sapiens_hsa046140.09399796
131Bladder cancer_Homo sapiens_hsa052190.09093718
132Carbon metabolism_Homo sapiens_hsa012000.06645984
133HIF-1 signaling pathway_Homo sapiens_hsa040660.06031567
134Notch signaling pathway_Homo sapiens_hsa043300.05346444
135Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.04757405
136Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.04392134
137NOD-like receptor signaling pathway_Homo sapiens_hsa046210.04390592
138RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.03473237
139Galactose metabolism_Homo sapiens_hsa000520.03379839
140Viral myocarditis_Homo sapiens_hsa054160.02934565
141Selenocompound metabolism_Homo sapiens_hsa004500.02912697
142NF-kappa B signaling pathway_Homo sapiens_hsa040640.02863557
143Type I diabetes mellitus_Homo sapiens_hsa049400.02783262
144Melanoma_Homo sapiens_hsa052180.00722381

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