ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ATP synthesis coupled proton transport (GO:0015986)	5.59973975
2	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.59973975
3	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.58517231
4	ribosomal small subunit assembly (GO:0000028)	5.53152921
5	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.86748740
6	NADH dehydrogenase complex assembly (GO:0010257)	4.86748740
7	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.86748740
8	negative regulation of thymocyte apoptotic process (GO:0070244)	4.83421747
9	V(D)J recombination (GO:0033151)	4.75790848
10	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	4.67695048
11	exocrine pancreas development (GO:0031017)	4.53157147
12	viral transcription (GO:0019083)	4.52857191
13	protein complex biogenesis (GO:0070271)	4.49456685
14	translational termination (GO:0006415)	4.35237448
15	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.24489359
16	pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)	4.19153886
17	mitochondrial respiratory chain complex assembly (GO:0033108)	4.14230994
18	pyrimidine nucleotide catabolic process (GO:0006244)	4.08015823
19	pyrimidine nucleoside monophosphate metabolic process (GO:0009129)	4.03086227
20	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.97931933
21	protein targeting to ER (GO:0045047)	3.89651553
22	cotranslational protein targeting to membrane (GO:0006613)	3.88278199
23	T cell lineage commitment (GO:0002360)	3.83465999
24	chaperone-mediated protein transport (GO:0072321)	3.81869764
25	respiratory electron transport chain (GO:0022904)	3.81082349
26	electron transport chain (GO:0022900)	3.77454966
27	translational elongation (GO:0006414)	3.77429437
28	UMP biosynthetic process (GO:0006222)	3.76214556
29	pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)	3.76214556
30	UMP metabolic process (GO:0046049)	3.76214556
31	pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)	3.76214556
32	deoxyribonucleotide catabolic process (GO:0009264)	3.71988601
33	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.71359309
34	regulation of thymocyte apoptotic process (GO:0070243)	3.64353251
35	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.63574360
36	protein-cofactor linkage (GO:0018065)	3.58482145
37	protein localization to endoplasmic reticulum (GO:0070972)	3.54900195
38	deoxyribose phosphate catabolic process (GO:0046386)	3.49984709
39	nucleotide salvage (GO:0043173)	3.47820142
40	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.44391193
41	mast cell activation involved in immune response (GO:0002279)	3.43450351
42	mast cell degranulation (GO:0043303)	3.43450351
43	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.41129767
44	cellular protein complex disassembly (GO:0043624)	3.36259091
45	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.34133925
46	viral life cycle (GO:0019058)	3.33368734
47	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	3.32597667
48	purine nucleotide salvage (GO:0032261)	3.30887808
49	ribosomal small subunit biogenesis (GO:0042274)	3.30740697
50	ubiquinone biosynthetic process (GO:0006744)	3.29875549
51	DNA deamination (GO:0045006)	3.29717533
52	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.29560461
53	respiratory chain complex IV assembly (GO:0008535)	3.26075384
54	negative regulation of B cell apoptotic process (GO:0002903)	3.25768609
55	behavioral response to nicotine (GO:0035095)	3.24084646
56	purine deoxyribonucleotide catabolic process (GO:0009155)	3.17067856
57	iron-sulfur cluster assembly (GO:0016226)	3.08310804
58	metallo-sulfur cluster assembly (GO:0031163)	3.08310804
59	ATP biosynthetic process (GO:0006754)	3.02675308
60	DNA strand elongation involved in DNA replication (GO:0006271)	3.02134543
61	maturation of SSU-rRNA (GO:0030490)	3.01658340
62	mast cell activation (GO:0045576)	2.97949501
63	translational initiation (GO:0006413)	2.97354997
64	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	2.95709292
65	somatic diversification of immune receptors (GO:0002200)	2.93192886
66	translation (GO:0006412)	2.92067012
67	somatic diversification of immune receptors via germline recombination within a single locus (GO:000	2.90284653
68	somatic cell DNA recombination (GO:0016444)	2.90284653
69	CTP metabolic process (GO:0046036)	2.89201486
70	CTP biosynthetic process (GO:0006241)	2.89201486
71	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.88927663
72	negative regulation of telomere maintenance (GO:0032205)	2.87737920
73	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.86368766
74	ubiquinone metabolic process (GO:0006743)	2.85801422
75	protein neddylation (GO:0045116)	2.85415716
76	nonmotile primary cilium assembly (GO:0035058)	2.84759627
77	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.84591166
78	2-deoxyribonucleotide metabolic process (GO:0009394)	2.84472635
79	activated T cell proliferation (GO:0050798)	2.83660002
80	negative regulation of T cell apoptotic process (GO:0070233)	2.83309162
81	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.80932225
82	pyrimidine dimer repair (GO:0006290)	2.79770415
83	proteasome assembly (GO:0043248)	2.78629694
84	cytochrome complex assembly (GO:0017004)	2.78268533
85	regulation of dendritic cell antigen processing and presentation (GO:0002604)	2.78180348
86	oxidative phosphorylation (GO:0006119)	2.77865825
87	DNA strand elongation (GO:0022616)	2.77026578
88	telomere maintenance via semi-conservative replication (GO:0032201)	2.76753516
89	water-soluble vitamin biosynthetic process (GO:0042364)	2.74782569
90	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.74101701
91	quinone biosynthetic process (GO:1901663)	2.72760727
92	platelet dense granule organization (GO:0060155)	2.72659570
93	protein complex disassembly (GO:0043241)	2.71463044
94	deoxyribose phosphate metabolic process (GO:0019692)	2.67878864
95	spliceosomal snRNP assembly (GO:0000387)	2.67507189
96	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.66817645
97	pyrimidine ribonucleoside biosynthetic process (GO:0046132)	2.65834735
98	regulation of cellular amino acid metabolic process (GO:0006521)	2.64296013
99	regulation of mitochondrial translation (GO:0070129)	2.63679236
100	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.63554222

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	6.32593172
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.88243906
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.73629829
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.73224325
5	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.34762977
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.29105991
7	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.08093854
8	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.02221468
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.00037774
10	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.95181804
11	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.88820665
12	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.78904690
13	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.64982544
14	E2F7_22180533_ChIP-Seq_HELA_Human	2.63341466
15	VDR_23849224_ChIP-Seq_CD4+_Human	2.41183778
16	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.32579003
17	ZNF274_21170338_ChIP-Seq_K562_Hela	2.23985334
18	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.17162106
19	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.04174454
20	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.99850111
21	FOXP3_21729870_ChIP-Seq_TREG_Human	1.95620129
22	IGF1R_20145208_ChIP-Seq_DFB_Human	1.90290255
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.88166316
24	MYC_18940864_ChIP-ChIP_HL60_Human	1.84795729
25	IRF1_19129219_ChIP-ChIP_H3396_Human	1.80576923
26	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.79628687
27	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.70714227
28	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.69308639
29	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.64213965
30	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.60515912
31	ELK1_19687146_ChIP-ChIP_HELA_Human	1.54803938
32	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.52593026
33	EWS_26573619_Chip-Seq_HEK293_Human	1.52588113
34	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.49202932
35	CIITA_25753668_ChIP-Seq_RAJI_Human	1.48460694
36	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.43481240
37	GABP_19822575_ChIP-Seq_HepG2_Human	1.40878254
38	EZH2_22144423_ChIP-Seq_EOC_Human	1.40473451
39	VDR_22108803_ChIP-Seq_LS180_Human	1.40308075
40	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.37816448
41	DCP1A_22483619_ChIP-Seq_HELA_Human	1.37816259
42	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.36919471
43	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.32965450
44	TP53_22573176_ChIP-Seq_HFKS_Human	1.32655901
45	TTF2_22483619_ChIP-Seq_HELA_Human	1.31501619
46	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.29935594
47	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.29553485
48	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.29553485
49	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.29189048
50	XRN2_22483619_ChIP-Seq_HELA_Human	1.28534564
51	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.27946178
52	ERG_20517297_ChIP-Seq_VCAP_Human	1.27439051
53	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.24164930
54	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.23465875
55	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.21915147
56	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.20897763
57	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.19737222
58	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.18067738
59	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.13922465
60	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.12941791
61	ERA_21632823_ChIP-Seq_H3396_Human	1.11588003
62	MYB_26560356_Chip-Seq_TH2_Human	1.10757326
63	AR_20517297_ChIP-Seq_VCAP_Human	1.10738705
64	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.08715055
65	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.06999068
66	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.05552100
67	KDM5A_27292631_Chip-Seq_BREAST_Human	1.05396034
68	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.04397263
69	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.03100448
70	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.01248389
71	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.01074039
72	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.99849400
73	CBP_20019798_ChIP-Seq_JUKART_Human	0.99849400
74	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.99543935
75	TAF2_19829295_ChIP-Seq_ESCs_Human	0.99392432
76	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.98746467
77	NANOG_20526341_ChIP-Seq_ESCs_Human	0.97236910
78	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	0.96829720
79	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.96820153
80	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.96776420
81	ER_23166858_ChIP-Seq_MCF-7_Human	0.95962171
82	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.95209032
83	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.95085099
84	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.95075403
85	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.94259271
86	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.91216583
87	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.91183789
88	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.90749178
89	P300_27268052_Chip-Seq_Bcells_Human	0.90245300
90	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.89829286
91	NCOR_22424771_ChIP-Seq_293T_Human	0.89416271
92	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.88816529
93	GATA3_26560356_Chip-Seq_TH2_Human	0.88477475
94	BCL6_27268052_Chip-Seq_Bcells_Human	0.88378423
95	P53_21459846_ChIP-Seq_SAOS-2_Human	0.87329412
96	SOX2_19829295_ChIP-Seq_ESCs_Human	0.86621477
97	NANOG_19829295_ChIP-Seq_ESCs_Human	0.86621477
98	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.86568624
99	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	0.86331080
100	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.86164659

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002876_abnormal_thyroid_physiology	3.31730279
2	MP0002132_abnormal_respiratory_system	3.18283150
3	MP0009278_abnormal_bone_marrow	3.17185195
4	MP0002166_altered_tumor_susceptibility	3.10999198
5	MP0010094_abnormal_chromosome_stability	2.96022489
6	MP0005671_abnormal_response_to	2.95570646
7	MP0002653_abnormal_ependyma_morphology	2.88408350
8	MP0001835_abnormal_antigen_presentation	2.75615391
9	MP0004147_increased_porphyrin_level	2.72384362
10	MP0000372_irregular_coat_pigmentation	2.71146582
11	MP0002006_tumorigenesis	2.47582508
12	MP0000685_abnormal_immune_system	2.41356944
13	MP0009379_abnormal_foot_pigmentation	2.28738214
14	MP0005387_immune_system_phenotype	2.25430199
15	MP0001790_abnormal_immune_system	2.25430199
16	MP0008058_abnormal_DNA_repair	2.23793935
17	MP0008877_abnormal_DNA_methylation	2.13996687
18	MP0003283_abnormal_digestive_organ	2.13841830
19	MP0006292_abnormal_olfactory_placode	2.10075377
20	MP0002095_abnormal_skin_pigmentation	2.03871609
21	MP0009785_altered_susceptibility_to	2.03810945
22	MP0001800_abnormal_humoral_immune	1.93166040
23	MP0008872_abnormal_physiological_respon	1.91523537
24	MP0003763_abnormal_thymus_physiology	1.85564021
25	MP0008875_abnormal_xenobiotic_pharmacok	1.78623680
26	MP0008057_abnormal_DNA_replication	1.70998465
27	MP0001485_abnormal_pinna_reflex	1.67632587
28	MP0004142_abnormal_muscle_tone	1.65793669
29	MP0002148_abnormal_hypersensitivity_rea	1.64177840
30	MP0005646_abnormal_pituitary_gland	1.58845579
31	MP0004742_abnormal_vestibular_system	1.54178373
32	MP0002102_abnormal_ear_morphology	1.47790890
33	MP0008007_abnormal_cellular_replicative	1.42708017
34	MP0005397_hematopoietic_system_phenotyp	1.37146639
35	MP0001545_abnormal_hematopoietic_system	1.37146639
36	MP0003787_abnormal_imprinting	1.36219680
37	MP0003646_muscle_fatigue	1.35860601
38	MP0005551_abnormal_eye_electrophysiolog	1.35181833
39	MP0002138_abnormal_hepatobiliary_system	1.35144198
40	MP0002160_abnormal_reproductive_system	1.31594262
41	MP0001905_abnormal_dopamine_level	1.30717947
42	MP0006036_abnormal_mitochondrial_physio	1.24866383
43	MP0006276_abnormal_autonomic_nervous	1.23755301
44	MP0002420_abnormal_adaptive_immunity	1.23361872
45	MP0002723_abnormal_immune_serum	1.23331662
46	MP0003786_premature_aging	1.22520553
47	MP0001819_abnormal_immune_cell	1.21642291
48	MP0002163_abnormal_gland_morphology	1.21448235
49	MP0002396_abnormal_hematopoietic_system	1.21390107
50	MP0005075_abnormal_melanosome_morpholog	1.20285959
51	MP0000569_abnormal_digit_pigmentation	1.13980218
52	MP0002452_abnormal_antigen_presenting	1.13629050
53	MP0005389_reproductive_system_phenotype	1.12905898
54	MP0005000_abnormal_immune_tolerance	1.08263516
55	MP0004133_heterotaxia	1.07487180
56	MP0005367_renal/urinary_system_phenotyp	1.05846324
57	MP0000516_abnormal_urinary_system	1.05846324
58	MP0001529_abnormal_vocalization	1.03918184
59	MP0009697_abnormal_copulation	1.00977623
60	MP0001879_abnormal_lymphatic_vessel	1.00596572
61	MP0002837_dystrophic_cardiac_calcinosis	0.98880028
62	MP0002398_abnormal_bone_marrow	0.98639081
63	MP0003806_abnormal_nucleotide_metabolis	0.98465772
64	MP0000716_abnormal_immune_system	0.98108433
65	MP0001986_abnormal_taste_sensitivity	0.96314575
66	MP0005410_abnormal_fertilization	0.95010900
67	MP0001919_abnormal_reproductive_system	0.93878443
68	MP0006072_abnormal_retinal_apoptosis	0.93668709
69	MP0004885_abnormal_endolymph	0.90216121
70	MP0005645_abnormal_hypothalamus_physiol	0.89953903
71	MP0003252_abnormal_bile_duct	0.89583791
72	MP0001486_abnormal_startle_reflex	0.88111595
73	MP0010155_abnormal_intestine_physiology	0.87280648
74	MP0000689_abnormal_spleen_morphology	0.86159886
75	MP0002429_abnormal_blood_cell	0.84670909
76	MP0001293_anophthalmia	0.84498198
77	MP0001663_abnormal_digestive_system	0.84264336
78	MP0003136_yellow_coat_color	0.81138129
79	MP0000427_abnormal_hair_cycle	0.80703052
80	MP0002638_abnormal_pupillary_reflex	0.80448210
81	MP0001764_abnormal_homeostasis	0.80315963
82	MP0008789_abnormal_olfactory_epithelium	0.78735063
83	MP0005195_abnormal_posterior_eye	0.76334196
84	MP0005084_abnormal_gallbladder_morpholo	0.75294772
85	MP0002736_abnormal_nociception_after	0.73835424
86	MP0005379_endocrine/exocrine_gland_phen	0.72418550
87	MP0002722_abnormal_immune_system	0.72387833
88	MP0005220_abnormal_exocrine_pancreas	0.71864484
89	MP0002075_abnormal_coat/hair_pigmentati	0.70371595
90	MP0000703_abnormal_thymus_morphology	0.69713034
91	MP0004957_abnormal_blastocyst_morpholog	0.69568657
92	MP0001929_abnormal_gametogenesis	0.69110393
93	MP0005253_abnormal_eye_physiology	0.68470017
94	MP0001188_hyperpigmentation	0.68145549
95	MP0009765_abnormal_xenobiotic_induced	0.68138568
96	MP0000462_abnormal_digestive_system	0.66064339
97	MP0005451_abnormal_body_composition	0.66005536
98	MP0005025_abnormal_response_to	0.65346208
99	MP0004043_abnormal_pH_regulation	0.63909732
100	MP0000026_abnormal_inner_ear	0.63518416

Predicted human phenotypes

Rank	Gene Set	Z-score
1	B lymphocytopenia (HP:0010976)	9.31887405
2	Abnormality of B cell number (HP:0010975)	8.36095721
3	Severe combined immunodeficiency (HP:0004430)	7.46459878
4	Thyroiditis (HP:0100646)	6.18881152
5	Hypoplasia of the thymus (HP:0000778)	6.13309839
6	Combined immunodeficiency (HP:0005387)	5.90102017
7	Panhypogammaglobulinemia (HP:0003139)	5.62067379
8	Hypoproteinemia (HP:0003075)	5.30875174
9	Agammaglobulinemia (HP:0004432)	4.46506322
10	Erythroderma (HP:0001019)	4.19029951
11	Acute necrotizing encephalopathy (HP:0006965)	4.13442308
12	T lymphocytopenia (HP:0005403)	4.02797086
13	Eosinophilia (HP:0001880)	3.97819145
14	Mitochondrial inheritance (HP:0001427)	3.93716457
15	Increased CSF lactate (HP:0002490)	3.53342874
16	Abnormal mitochondria in muscle tissue (HP:0008316)	3.53280144
17	IgG deficiency (HP:0004315)	3.49637687
18	Hepatocellular necrosis (HP:0001404)	3.46694788
19	Granulocytopenia (HP:0001913)	3.40725426
20	Acute encephalopathy (HP:0006846)	3.33804334
21	Progressive macrocephaly (HP:0004481)	3.32460731
22	Abnormality of T cell number (HP:0011839)	3.31782825
23	Abnormality of eosinophils (HP:0001879)	3.21340426
24	Hepatic necrosis (HP:0002605)	3.12516015
25	Cerebral edema (HP:0002181)	3.01743716
26	Aplasia/Hypoplasia of the thymus (HP:0010515)	2.72934742
27	Molar tooth sign on MRI (HP:0002419)	2.71513526
28	Abnormality of midbrain morphology (HP:0002418)	2.71513526
29	Meningitis (HP:0001287)	2.65379302
30	Recurrent viral infections (HP:0004429)	2.63337499
31	Chronic sinusitis (HP:0011109)	2.57885069
32	Abnormality of T cells (HP:0002843)	2.54157593
33	Type II lissencephaly (HP:0007260)	2.37933559
34	Sepsis (HP:0100806)	2.34520771
35	Lactic acidosis (HP:0003128)	2.34216318
36	Pendular nystagmus (HP:0012043)	2.29887502
37	Cleft eyelid (HP:0000625)	2.25365708
38	Methylmalonic aciduria (HP:0012120)	2.23758174
39	Optic disc pallor (HP:0000543)	2.19288333
40	Recurrent fungal infections (HP:0002841)	2.19031801
41	Respiratory failure (HP:0002878)	2.18323543
42	Increased serum lactate (HP:0002151)	2.13407533
43	Abnormality of the thymus (HP:0000777)	2.11848874
44	Testicular atrophy (HP:0000029)	2.09609899
45	Abolished electroretinogram (ERG) (HP:0000550)	2.07858665
46	Abnormal number of erythroid precursors (HP:0012131)	2.07378071
47	Increased hepatocellular lipid droplets (HP:0006565)	2.07067973
48	Renal cortical cysts (HP:0000803)	2.06759065
49	Methylmalonic acidemia (HP:0002912)	2.06442692
50	Pancreatic cysts (HP:0001737)	2.05355201
51	Congenital stationary night blindness (HP:0007642)	2.04791007
52	Cerebellar dysplasia (HP:0007033)	2.03864133
53	Colon cancer (HP:0003003)	2.02449743
54	Abnormality of cells of the erythroid lineage (HP:0012130)	1.94650507
55	Prostate neoplasm (HP:0100787)	1.93876656
56	Pancytopenia (HP:0001876)	1.93251360
57	Leukodystrophy (HP:0002415)	1.91368020
58	Abnormality of alanine metabolism (HP:0010916)	1.90320598
59	Hyperalaninemia (HP:0003348)	1.90320598
60	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.90320598
61	Leukocytosis (HP:0001974)	1.89534376
62	3-Methylglutaconic aciduria (HP:0003535)	1.88268952
63	Increased intramyocellular lipid droplets (HP:0012240)	1.88232353
64	Abnormality of the pons (HP:0007361)	1.88156568
65	Cerebral palsy (HP:0100021)	1.87426185
66	Papilloma (HP:0012740)	1.87374078
67	Verrucae (HP:0200043)	1.87374078
68	Medial flaring of the eyebrow (HP:0010747)	1.87156220
69	Reticulocytopenia (HP:0001896)	1.87120700
70	Macrocytic anemia (HP:0001972)	1.85738213
71	Lipid accumulation in hepatocytes (HP:0006561)	1.84386381
72	Autoimmune thrombocytopenia (HP:0001973)	1.82825828
73	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.81679430
74	Exertional dyspnea (HP:0002875)	1.81516197
75	Cellular immunodeficiency (HP:0005374)	1.80874549
76	Renal Fanconi syndrome (HP:0001994)	1.79921943
77	Progressive microcephaly (HP:0000253)	1.78490837
78	Hypoplasia of the pons (HP:0012110)	1.78090565
79	Exercise intolerance (HP:0003546)	1.75967280
80	Dicarboxylic aciduria (HP:0003215)	1.75948632
81	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.75948632
82	Lethargy (HP:0001254)	1.75857627
83	Partial agenesis of the corpus callosum (HP:0001338)	1.73381020
84	Increased neuronal autofluorescent lipopigment (HP:0002074)	1.71971604
85	Entropion (HP:0000621)	1.70823990
86	Lymphoma (HP:0002665)	1.70499595
87	Bilateral microphthalmos (HP:0007633)	1.68863325
88	Abnormality of DNA repair (HP:0003254)	1.68647527
89	Recurrent pneumonia (HP:0006532)	1.68435597
90	Abnormality of the labia minora (HP:0012880)	1.68054323
91	Hypoplasia of the radius (HP:0002984)	1.67620271
92	Abnormality of macular pigmentation (HP:0008002)	1.65301175
93	11 pairs of ribs (HP:0000878)	1.64624388
94	Abnormal rod and cone electroretinograms (HP:0008323)	1.63588471
95	Pancreatic fibrosis (HP:0100732)	1.61165118
96	Visual hallucinations (HP:0002367)	1.59486751
97	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.58964146
98	True hermaphroditism (HP:0010459)	1.58936687
99	Pallor (HP:0000980)	1.58074294
100	Nephrotic syndrome (HP:0000100)	1.57125968

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	5.15002337
2	MAP4K1	4.26977301
3	TESK2	3.25215526
4	PBK	3.11282669
5	TXK	3.05933886
6	NUAK1	2.74931210
7	KDR	2.56621710
8	BMPR1B	2.47704906
9	KIT	2.29295550
10	MAP3K11	2.26669604
11	WNK3	2.11856568
12	NME1	2.03157115
13	CDK19	1.88904568
14	BCKDK	1.88408910
15	TAF1	1.82539172
16	SCYL2	1.81266630
17	FLT3	1.71692657
18	SYK	1.70049845
19	VRK1	1.61184448
20	ACVR1B	1.60544162
21	LIMK1	1.58018261
22	MAP3K12	1.47603703
23	WNK4	1.46514837
24	CSF1R	1.44517462
25	ADRBK2	1.44061536
26	SIK2	1.40887952
27	GRK1	1.34613689
28	SRPK1	1.30473582
29	PIK3CG	1.27214900
30	FRK	1.23773818
31	DYRK2	1.21262908
32	MAPK13	1.20755758
33	MAP4K2	1.12408614
34	PDK2	1.10110127
35	TGFBR1	1.09803619
36	WEE1	1.07706248
37	STK16	1.06670162
38	MUSK	1.03263929
39	MKNK1	1.00478940
40	LYN	0.99713594
41	NEK1	0.98437786
42	MAPKAPK5	0.97651633
43	TNIK	0.97048997
44	MATK	0.94661312
45	TLK1	0.93888577
46	DAPK1	0.87075576
47	TAOK3	0.87010465
48	BTK	0.83415289
49	RPS6KB1	0.82181166
50	NEK2	0.74901222
51	LRRK2	0.73918076
52	PLK4	0.73908181
53	EIF2AK3	0.73780382
54	CDK8	0.72580955
55	PIM2	0.68163269
56	ATR	0.67188022
57	BRSK1	0.64237504
58	ZAK	0.62982671
59	TEC	0.62469432
60	CDK9	0.61686024
61	FES	0.59995662
62	AURKA	0.59991934
63	SMG1	0.59210137
64	DAPK3	0.58681515
65	MAP2K7	0.58144141
66	PASK	0.58069304
67	LCK	0.56752445
68	PNCK	0.56680663
69	ITK	0.56140792
70	ABL2	0.55950976
71	ADRBK1	0.55189185
72	INSRR	0.53207124
73	TIE1	0.52975668
74	OXSR1	0.51484246
75	TESK1	0.51458058
76	CHEK2	0.51063334
77	GRK5	0.49254574
78	AURKB	0.49129470
79	NME2	0.48413927
80	RPS6KB2	0.42664407
81	CSNK2A1	0.41702623
82	CDC7	0.40459914
83	IKBKB	0.39069669
84	PHKG2	0.38670517
85	PHKG1	0.38670517
86	BMPR2	0.37872036
87	MKNK2	0.35883710
88	RPS6KA4	0.32635159
89	ERBB2	0.31895327
90	PLK1	0.31042356
91	MAPK11	0.30708372
92	PRKACA	0.30518505
93	CDK7	0.29848654
94	CSNK2A2	0.29496630
95	PINK1	0.29164376
96	CAMK2D	0.28950448
97	STK39	0.28272230
98	OBSCN	0.27587461
99	PIM1	0.24931389
100	NLK	0.24846865

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary immunodeficiency_Homo sapiens_hsa05340	4.36834033
2	Ribosome_Homo sapiens_hsa03010	3.86113946
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.65374113
4	Non-homologous end-joining_Homo sapiens_hsa03450	3.61971357
5	Proteasome_Homo sapiens_hsa03050	3.44242619
6	DNA replication_Homo sapiens_hsa03030	3.34408095
7	Parkinsons disease_Homo sapiens_hsa05012	3.22866989
8	Mismatch repair_Homo sapiens_hsa03430	2.47676689
9	Huntingtons disease_Homo sapiens_hsa05016	2.19935843
10	Alzheimers disease_Homo sapiens_hsa05010	2.15846003
11	Nucleotide excision repair_Homo sapiens_hsa03420	2.11878108
12	Protein export_Homo sapiens_hsa03060	2.07286277
13	RNA polymerase_Homo sapiens_hsa03020	1.96198668
14	Sulfur metabolism_Homo sapiens_hsa00920	1.94264674
15	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.93259276
16	Base excision repair_Homo sapiens_hsa03410	1.73713253
17	One carbon pool by folate_Homo sapiens_hsa00670	1.70417185
18	Pyrimidine metabolism_Homo sapiens_hsa00240	1.69698758
19	Homologous recombination_Homo sapiens_hsa03440	1.68035085
20	Fanconi anemia pathway_Homo sapiens_hsa03460	1.63280757
21	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.62181324
22	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.61867608
23	Cardiac muscle contraction_Homo sapiens_hsa04260	1.58617367
24	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.55102489
25	Asthma_Homo sapiens_hsa05310	1.54608459
26	Phototransduction_Homo sapiens_hsa04744	1.52801004
27	Spliceosome_Homo sapiens_hsa03040	1.46103071
28	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.41502066
29	Allograft rejection_Homo sapiens_hsa05330	1.40731294
30	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.36908812
31	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.35782213
32	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.25770986
33	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.20838184
34	Linoleic acid metabolism_Homo sapiens_hsa00591	1.20182500
35	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.18216191
36	Fatty acid elongation_Homo sapiens_hsa00062	1.17807664
37	Purine metabolism_Homo sapiens_hsa00230	1.15633717
38	Caffeine metabolism_Homo sapiens_hsa00232	1.13819966
39	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.03274899
40	RNA degradation_Homo sapiens_hsa03018	1.02949132
41	RNA transport_Homo sapiens_hsa03013	1.00483427
42	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.96406303
43	Sulfur relay system_Homo sapiens_hsa04122	0.95305146
44	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.91987990
45	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.88862229
46	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.83935989
47	Graft-versus-host disease_Homo sapiens_hsa05332	0.83697789
48	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.83528731
49	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.78257586
50	Type I diabetes mellitus_Homo sapiens_hsa04940	0.77796177
51	Regulation of autophagy_Homo sapiens_hsa04140	0.77565690
52	Propanoate metabolism_Homo sapiens_hsa00640	0.74627298
53	Basal transcription factors_Homo sapiens_hsa03022	0.73759525
54	Fatty acid metabolism_Homo sapiens_hsa01212	0.72950131
55	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.72648821
56	Antigen processing and presentation_Homo sapiens_hsa04612	0.72112534
57	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.70185267
58	Nitrogen metabolism_Homo sapiens_hsa00910	0.70044619
59	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.69588487
60	Peroxisome_Homo sapiens_hsa04146	0.67345928
61	Metabolic pathways_Homo sapiens_hsa01100	0.64970999
62	Tryptophan metabolism_Homo sapiens_hsa00380	0.64142182
63	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.63966468
64	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.63558654
65	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.61611890
66	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.59118983
67	Butanoate metabolism_Homo sapiens_hsa00650	0.55915628
68	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.54708915
69	Glutathione metabolism_Homo sapiens_hsa00480	0.53534451
70	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.53330937
71	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.48545095
72	Nicotine addiction_Homo sapiens_hsa05033	0.48226014
73	p53 signaling pathway_Homo sapiens_hsa04115	0.47565115
74	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.45657290
75	Chemical carcinogenesis_Homo sapiens_hsa05204	0.42297961
76	Olfactory transduction_Homo sapiens_hsa04740	0.41870048
77	Pyruvate metabolism_Homo sapiens_hsa00620	0.40671945
78	Selenocompound metabolism_Homo sapiens_hsa00450	0.37537701
79	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.35300767
80	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.32002210
81	mRNA surveillance pathway_Homo sapiens_hsa03015	0.31715861
82	Morphine addiction_Homo sapiens_hsa05032	0.25542083
83	Retinol metabolism_Homo sapiens_hsa00830	0.24596423
84	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.24414245
85	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.24087633
86	Rheumatoid arthritis_Homo sapiens_hsa05323	0.24063353
87	Cell cycle_Homo sapiens_hsa04110	0.23724226
88	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.22910967
89	Ether lipid metabolism_Homo sapiens_hsa00565	0.22825438
90	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.19577420
91	Taste transduction_Homo sapiens_hsa04742	0.18874690
92	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.18828422
93	Fat digestion and absorption_Homo sapiens_hsa04975	0.18544402
94	Collecting duct acid secretion_Homo sapiens_hsa04966	0.17853960
95	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.15811821
96	HTLV-I infection_Homo sapiens_hsa05166	0.15486459
97	Tyrosine metabolism_Homo sapiens_hsa00350	0.15257454
98	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.14517631
99	Folate biosynthesis_Homo sapiens_hsa00790	0.13422927
100	Herpes simplex infection_Homo sapiens_hsa05168	0.12725091

SNRPD2P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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