SNRPE

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a core component of U small nuclear ribonucleoproteins, which are key components of the pre-mRNA processing spliceosome. The encoded protein plays a role in the 3' end processing of histone transcripts. This protein is one of the targets in the autoimmune disease systemic lupus erythematosus, and mutations in this gene have been associated with hypotrichosis. Several pseudogenes of this gene have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.69155043
2viral transcription (GO:0019083)6.67501282
3ribosomal small subunit biogenesis (GO:0042274)6.60110028
4translational termination (GO:0006415)6.48175485
5maturation of SSU-rRNA (GO:0030490)5.74749587
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.64725620
7cotranslational protein targeting to membrane (GO:0006613)5.57334407
8translational elongation (GO:0006414)5.56842631
9protein targeting to ER (GO:0045047)5.52558379
10establishment of protein localization to endoplasmic reticulum (GO:0072599)5.24895070
11protein localization to endoplasmic reticulum (GO:0070972)5.21038038
12nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.13756505
13viral life cycle (GO:0019058)5.10624900
14cellular protein complex disassembly (GO:0043624)5.09992443
15translational initiation (GO:0006413)5.05910745
16ribosomal large subunit biogenesis (GO:0042273)5.00830612
17chaperone-mediated protein transport (GO:0072321)4.77279651
18mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.72939276
19DNA deamination (GO:0045006)4.49494058
20protein complex disassembly (GO:0043241)4.45867564
21mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.37437684
22respiratory electron transport chain (GO:0022904)4.34370639
23ribonucleoprotein complex biogenesis (GO:0022613)4.29719909
24proteasome assembly (GO:0043248)4.25311641
25electron transport chain (GO:0022900)4.24778538
26macromolecular complex disassembly (GO:0032984)4.22513498
27telomere maintenance via semi-conservative replication (GO:0032201)4.22307245
28translation (GO:0006412)4.22140422
29DNA strand elongation involved in DNA replication (GO:0006271)4.20975918
30ATP synthesis coupled proton transport (GO:0015986)4.12138565
31energy coupled proton transport, down electrochemical gradient (GO:0015985)4.12138565
32CENP-A containing nucleosome assembly (GO:0034080)4.02325522
33establishment of integrated proviral latency (GO:0075713)4.00840512
34DNA strand elongation (GO:0022616)4.00327962
35nuclear-transcribed mRNA catabolic process (GO:0000956)3.95444580
36transcription elongation from RNA polymerase III promoter (GO:0006385)3.92456829
37termination of RNA polymerase III transcription (GO:0006386)3.92456829
38chromatin remodeling at centromere (GO:0031055)3.91412260
39negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.91253045
40formation of translation preinitiation complex (GO:0001731)3.86126976
41rRNA processing (GO:0006364)3.81517474
42kinetochore organization (GO:0051383)3.81012023
43protein complex biogenesis (GO:0070271)3.79849795
44DNA double-strand break processing (GO:0000729)3.79253427
45telomere maintenance via recombination (GO:0000722)3.79119854
46deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.76921971
47mitochondrial respiratory chain complex assembly (GO:0033108)3.75655952
48DNA replication initiation (GO:0006270)3.75245364
49mRNA catabolic process (GO:0006402)3.73408321
50mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.68824120
51mitochondrial respiratory chain complex I assembly (GO:0032981)3.68824120
52NADH dehydrogenase complex assembly (GO:0010257)3.68824120
53positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.67650202
54regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.66572509
55rRNA metabolic process (GO:0016072)3.66451100
56kinetochore assembly (GO:0051382)3.65801358
57anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.64838894
58* spliceosomal snRNP assembly (GO:0000387)3.63351531
59exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.62152478
60negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.61155640
61negative regulation of ligase activity (GO:0051352)3.61155640
62protein targeting to membrane (GO:0006612)3.57532647
63DNA damage response, detection of DNA damage (GO:0042769)3.56807717
647-methylguanosine mRNA capping (GO:0006370)3.55924249
65regulation of mitochondrial translation (GO:0070129)3.55875858
66nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.54141936
67DNA replication-independent nucleosome assembly (GO:0006336)3.53944098
68DNA replication-independent nucleosome organization (GO:0034724)3.53944098
69mitotic recombination (GO:0006312)3.53198133
70cellular component biogenesis (GO:0044085)3.53078117
71RNA capping (GO:0036260)3.52502568
727-methylguanosine RNA capping (GO:0009452)3.52502568
73RNA catabolic process (GO:0006401)3.51944713
74DNA replication checkpoint (GO:0000076)3.48637879
75regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.48003585
76regulation of mitotic spindle checkpoint (GO:1903504)3.48003585
77transcription-coupled nucleotide-excision repair (GO:0006283)3.46728242
78DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.43806487
79signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.38750980
80intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.38750980
81cullin deneddylation (GO:0010388)3.37372740
82nucleotide-excision repair, DNA gap filling (GO:0006297)3.36337767
83signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.36074122
84signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.36074122
85signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.36074122
86rRNA modification (GO:0000154)3.34765959
87telomere maintenance via telomere lengthening (GO:0010833)3.33413404
88signal transduction involved in DNA integrity checkpoint (GO:0072401)3.29973434
89signal transduction involved in DNA damage checkpoint (GO:0072422)3.29973434
90transcription elongation from RNA polymerase I promoter (GO:0006362)3.29948332
91DNA ligation (GO:0006266)3.28340125
92signal transduction involved in cell cycle checkpoint (GO:0072395)3.26907899
93termination of RNA polymerase I transcription (GO:0006363)3.26375165
94mitotic metaphase plate congression (GO:0007080)3.24597255
95regulation of cellular amino acid metabolic process (GO:0006521)3.23037683
96establishment of protein localization to mitochondrial membrane (GO:0090151)3.21955018
97establishment of viral latency (GO:0019043)3.20284592
98respiratory chain complex IV assembly (GO:0008535)3.20052662
99antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.19801216
100* spliceosomal complex assembly (GO:0000245)3.19434866
101histone exchange (GO:0043486)3.16682569
102ribosome biogenesis (GO:0042254)3.16397396
103protein targeting to mitochondrion (GO:0006626)3.15737157
104positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.15687141
105DNA catabolic process, exonucleolytic (GO:0000738)3.14767799
106pseudouridine synthesis (GO:0001522)3.13168785
107purine nucleobase biosynthetic process (GO:0009113)3.12568453
108GTP biosynthetic process (GO:0006183)3.12105545
109oxidative phosphorylation (GO:0006119)3.11099378
110transcription from RNA polymerase I promoter (GO:0006360)3.10493522
111nucleobase biosynthetic process (GO:0046112)3.09146422
112ribosome assembly (GO:0042255)3.08283843
113* histone mRNA metabolic process (GO:0008334)3.06974957
114protein deneddylation (GO:0000338)3.04613922
115inner mitochondrial membrane organization (GO:0007007)3.03887376
116protein localization to mitochondrion (GO:0070585)3.03289332
117tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.02689558
118RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.02689558
119positive regulation of ligase activity (GO:0051351)3.02621688
120cell cycle G1/S phase transition (GO:0044843)3.01254895
121G1/S transition of mitotic cell cycle (GO:0000082)3.01254895
122protein localization to kinetochore (GO:0034501)3.00306821
123viral mRNA export from host cell nucleus (GO:0046784)3.00131618
124protein neddylation (GO:0045116)2.99701852
125DNA replication-dependent nucleosome assembly (GO:0006335)2.99658253
126DNA replication-dependent nucleosome organization (GO:0034723)2.99658253
127regulation of helicase activity (GO:0051095)2.98873521
128establishment of protein localization to mitochondrion (GO:0072655)2.98715445
129antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.98668562
130negative regulation of DNA-dependent DNA replication (GO:2000104)2.96652614
131ATP biosynthetic process (GO:0006754)2.93627430
132cytochrome complex assembly (GO:0017004)2.92410101

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.90114896
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.79750113
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.21446543
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.93331617
5* GABP_17652178_ChIP-ChIP_JURKAT_Human3.91729820
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.82835054
7* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.73046224
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.51573948
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.37384204
10* ETS1_20019798_ChIP-Seq_JURKAT_Human3.34202565
11MYC_19079543_ChIP-ChIP_MESCs_Mouse3.31024197
12CREB1_15753290_ChIP-ChIP_HEK293T_Human3.21722623
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.20967540
14MYC_18358816_ChIP-ChIP_MESCs_Mouse3.11183022
15FOXM1_23109430_ChIP-Seq_U2OS_Human3.03888366
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.03349783
17* MYC_19030024_ChIP-ChIP_MESCs_Mouse3.02238414
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.01458907
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.83430882
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.67718816
21XRN2_22483619_ChIP-Seq_HELA_Human2.65577360
22* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.63365922
23* VDR_23849224_ChIP-Seq_CD4+_Human2.60016378
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.50982353
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.47816182
26NELFA_20434984_ChIP-Seq_ESCs_Mouse2.41780565
27DCP1A_22483619_ChIP-Seq_HELA_Human2.35058510
28TTF2_22483619_ChIP-Seq_HELA_Human2.29252577
29* ELK1_19687146_ChIP-ChIP_HELA_Human2.24863761
30* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.23544864
31* FOXP3_21729870_ChIP-Seq_TREG_Human2.16064665
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.06673082
33THAP11_20581084_ChIP-Seq_MESCs_Mouse1.94827881
34HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.91695735
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.88423543
36MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.87729008
37* GABP_19822575_ChIP-Seq_HepG2_Human1.86945501
38EWS_26573619_Chip-Seq_HEK293_Human1.83164286
39* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.80106833
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.79088934
41* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.78921337
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.76608714
43ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.74486800
44POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.71758628
45FUS_26573619_Chip-Seq_HEK293_Human1.71160159
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.69757043
47MYCN_18555785_ChIP-Seq_MESCs_Mouse1.66676232
48AR_21909140_ChIP-Seq_LNCAP_Human1.65970057
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.63299091
50PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61863603
51NANOG_18555785_ChIP-Seq_MESCs_Mouse1.60959911
52YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.58044579
53* E2F1_21310950_ChIP-Seq_MCF-7_Human1.56769389
54SALL1_21062744_ChIP-ChIP_HESCs_Human1.54951367
55POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.49295220
56VDR_22108803_ChIP-Seq_LS180_Human1.47514955
57ZNF274_21170338_ChIP-Seq_K562_Hela1.46990982
58PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.45143089
59TP63_19390658_ChIP-ChIP_HaCaT_Human1.43977142
60* ELK1_22589737_ChIP-Seq_MCF10A_Human1.40528008
61* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.37868984
62FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.37102349
63MYC_18940864_ChIP-ChIP_HL60_Human1.34490087
64KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.34190627
65ERG_20887958_ChIP-Seq_HPC-7_Mouse1.33417694
66CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.32245876
67CIITA_25753668_ChIP-Seq_RAJI_Human1.31962536
68RBPJ_22232070_ChIP-Seq_NCS_Mouse1.28525104
69PADI4_21655091_ChIP-ChIP_MCF-7_Human1.23613805
70ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.23169568
71NOTCH1_21737748_ChIP-Seq_TLL_Human1.21611012
72POU3F2_20337985_ChIP-ChIP_501MEL_Human1.21588282
73SOX2_18555785_ChIP-Seq_MESCs_Mouse1.21334514
74IGF1R_20145208_ChIP-Seq_DFB_Human1.20256701
75FLI1_27457419_Chip-Seq_LIVER_Mouse1.18806923
76SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.12750622
77* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.11287167
78KDM5A_27292631_Chip-Seq_BREAST_Human1.10155685
79TAF15_26573619_Chip-Seq_HEK293_Human1.09253423
80CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.09189995
81CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05649934
82* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.04678813
83SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.03424749
84IRF1_19129219_ChIP-ChIP_H3396_Human1.02855377
85CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.02154697
86MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99427498
87CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.98934401
88BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96506812
89P300_19829295_ChIP-Seq_ESCs_Human0.95134933
90E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.94267664
91DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.91482836
92SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.91308740
93CTBP1_25329375_ChIP-Seq_LNCAP_Human0.89852479
94TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.89498878
95PCGF2_27294783_Chip-Seq_ESCs_Mouse0.88020868
96SPI1_23547873_ChIP-Seq_NB4_Human0.87816062
97GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.84578250
98ZFP57_27257070_Chip-Seq_ESCs_Mouse0.84113588
99FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.84040759
100GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.83904021
101CTBP2_25329375_ChIP-Seq_LNCAP_Human0.83840117
102POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.83467799
103SOX17_20123909_ChIP-Seq_XEN_Mouse0.82756609
104POU5F1_16153702_ChIP-ChIP_HESCs_Human0.81028612
105OCT4_18692474_ChIP-Seq_MEFs_Mouse0.80606335
106KLF4_18555785_ChIP-Seq_MESCs_Mouse0.79684069
107STAT3_1855785_ChIP-Seq_MESCs_Mouse0.79037926
108TP53_22573176_ChIP-Seq_HFKS_Human0.78865097
109SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.78421980
110EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.77715480
111* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.77497632
112TFEB_21752829_ChIP-Seq_HELA_Human0.77073610
113HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.76083878
114SOX2_18692474_ChIP-Seq_MEFs_Mouse0.75812488
115* ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.74676229
116* NANOG_16153702_ChIP-ChIP_HESCs_Human0.74265624
117NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.73535042
118DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.73175954
119BP1_19119308_ChIP-ChIP_Hs578T_Human0.73132215
120* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72395130
121SOX2_16153702_ChIP-ChIP_HESCs_Human0.71469948
122* CTCF_18555785_ChIP-Seq_MESCs_Mouse0.71318555
123NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.70901935
124TCF3_18692474_ChIP-Seq_MEFs_Mouse0.69194622

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.40446759
2MP0009379_abnormal_foot_pigmentation4.40895266
3MP0004957_abnormal_blastocyst_morpholog4.25350447
4MP0010094_abnormal_chromosome_stability4.01536041
5MP0003111_abnormal_nucleus_morphology3.71452392
6MP0003077_abnormal_cell_cycle3.67004141
7MP0008057_abnormal_DNA_replication3.50685040
8MP0008058_abnormal_DNA_repair3.21478591
9MP0008932_abnormal_embryonic_tissue2.88293266
10MP0008007_abnormal_cellular_replicative2.60935799
11MP0003786_premature_aging2.34231234
12MP0002102_abnormal_ear_morphology2.12869426
13MP0006292_abnormal_olfactory_placode2.03515947
14MP0003123_paternal_imprinting2.01035723
15MP0003315_abnormal_perineum_morphology1.99464325
16MP0003718_maternal_effect1.93264523
17MP0009697_abnormal_copulation1.85692130
18MP0002938_white_spotting1.77854220
19MP0000350_abnormal_cell_proliferation1.70982130
20MP0008877_abnormal_DNA_methylation1.65853741
21MP0003880_abnormal_central_pattern1.62622896
22MP0010030_abnormal_orbit_morphology1.61684117
23MP0002132_abnormal_respiratory_system1.60536991
24MP0001730_embryonic_growth_arrest1.60143966
25MP0002396_abnormal_hematopoietic_system1.57661196
26MP0003136_yellow_coat_color1.55157207
27MP0005394_taste/olfaction_phenotype1.54069332
28MP0005499_abnormal_olfactory_system1.54069332
29MP0000490_abnormal_crypts_of1.52787214
30MP0001529_abnormal_vocalization1.51413950
31MP0009333_abnormal_splenocyte_physiolog1.51149616
32MP0003941_abnormal_skin_development1.46670402
33MP0002234_abnormal_pharynx_morphology1.41821718
34MP0003186_abnormal_redox_activity1.41341592
35MP0000631_abnormal_neuroendocrine_gland1.36440015
36MP0005253_abnormal_eye_physiology1.34667806
37MP0000566_synostosis1.34663810
38MP0003567_abnormal_fetal_cardiomyocyte1.28121977
39MP0000313_abnormal_cell_death1.27719274
40MP0005174_abnormal_tail_pigmentation1.27210600
41MP0001697_abnormal_embryo_size1.24322391
42MP0002736_abnormal_nociception_after1.22839050
43MP0002233_abnormal_nose_morphology1.21991001
44MP0002163_abnormal_gland_morphology1.21953822
45MP0002638_abnormal_pupillary_reflex1.20437754
46MP0003121_genomic_imprinting1.19575610
47MP0004133_heterotaxia1.19521524
48MP0003119_abnormal_digestive_system1.19409218
49MP0008789_abnormal_olfactory_epithelium1.16715453
50MP0006035_abnormal_mitochondrial_morpho1.14204897
51MP0001485_abnormal_pinna_reflex1.13566309
52MP0002095_abnormal_skin_pigmentation1.12418735
53MP0005408_hypopigmentation1.11611281
54MP0003890_abnormal_embryonic-extraembry1.11063796
55MP0005084_abnormal_gallbladder_morpholo1.11027588
56MP0002210_abnormal_sex_determination1.10449617
57MP0003763_abnormal_thymus_physiology1.09316189
58MP0002080_prenatal_lethality1.09216515
59MP0002697_abnormal_eye_size1.07946738
60MP0002019_abnormal_tumor_incidence1.07665024
61MP0000049_abnormal_middle_ear1.07557818
62MP0006036_abnormal_mitochondrial_physio1.06561732
63MP0001984_abnormal_olfaction1.05974971
64MP0002085_abnormal_embryonic_tissue1.05915785
65MP0001853_heart_inflammation1.05645333
66MP0004142_abnormal_muscle_tone1.05593986
67MP0003938_abnormal_ear_development1.05520881
68MP0001293_anophthalmia1.04032563
69MP0002751_abnormal_autonomic_nervous1.04001992
70MP0008995_early_reproductive_senescence1.02938542
71MP0001672_abnormal_embryogenesis/_devel1.02494686
72MP0005380_embryogenesis_phenotype1.02494686
73MP0000372_irregular_coat_pigmentation1.02290059
74MP0002837_dystrophic_cardiac_calcinosis1.01853646
75MP0001188_hyperpigmentation1.01586821
76MP0005391_vision/eye_phenotype1.00697343
77MP0001764_abnormal_homeostasis0.96485597
78MP0001145_abnormal_male_reproductive0.94230030
79MP0003011_delayed_dark_adaptation0.94218803
80MP0002090_abnormal_vision0.93632574
81MP0000647_abnormal_sebaceous_gland0.93187440
82MP0002653_abnormal_ependyma_morphology0.92993770
83MP0000703_abnormal_thymus_morphology0.92990256
84MP0002160_abnormal_reproductive_system0.92008061
85MP0005551_abnormal_eye_electrophysiolog0.91604527
86MP0004808_abnormal_hematopoietic_stem0.91561618
87MP0001286_abnormal_eye_development0.91396720
88MP0002398_abnormal_bone_marrow0.91323266
89MP0005075_abnormal_melanosome_morpholog0.90145898
90MP0002277_abnormal_respiratory_mucosa0.89970494
91MP0001727_abnormal_embryo_implantation0.89416347
92MP0003122_maternal_imprinting0.88859849
93MP0002722_abnormal_immune_system0.88449867
94MP0003937_abnormal_limbs/digits/tail_de0.86919822
95MP0006276_abnormal_autonomic_nervous0.86278468
96MP0001905_abnormal_dopamine_level0.85834480
97MP0003755_abnormal_palate_morphology0.85256797
98MP0001835_abnormal_antigen_presentation0.84547081
99MP0005389_reproductive_system_phenotype0.83569104
100MP0001119_abnormal_female_reproductive0.82044458
101MP0000653_abnormal_sex_gland0.81967038
102MP0003984_embryonic_growth_retardation0.81250883
103MP0005671_abnormal_response_to0.81242414
104MP0000689_abnormal_spleen_morphology0.79972624
105MP0002088_abnormal_embryonic_growth/wei0.79476546
106MP0005248_abnormal_Harderian_gland0.78631654
107MP0002282_abnormal_trachea_morphology0.78336781
108MP0004215_abnormal_myocardial_fiber0.78296627
109MP0001929_abnormal_gametogenesis0.77750763
110MP0000858_altered_metastatic_potential0.77499020
111MP0002084_abnormal_developmental_patter0.77047037
112MP0005195_abnormal_posterior_eye0.76874408
113MP0006054_spinal_hemorrhage0.75932087
114MP0000015_abnormal_ear_pigmentation0.75537356
115MP0003787_abnormal_imprinting0.74463113
116MP0002429_abnormal_blood_cell0.74241138
117MP0000358_abnormal_cell_content/0.73772061
118MP0003698_abnormal_male_reproductive0.70742064
119MP0003861_abnormal_nervous_system0.70715358
120MP0000778_abnormal_nervous_system0.70455688
121MP0001177_atelectasis0.69984408
122MP0005171_absent_coat_pigmentation0.69039274
123MP0005187_abnormal_penis_morphology0.68910501
124MP0000537_abnormal_urethra_morphology0.68496771
125MP0004381_abnormal_hair_follicle0.68324674
126MP0001324_abnormal_eye_pigmentation0.68202218
127MP0002752_abnormal_somatic_nervous0.68131152
128MP0009785_altered_susceptibility_to0.67429059
129MP0002111_abnormal_tail_morphology0.67135984
130MP0002148_abnormal_hypersensitivity_rea0.66560167
131MP0002086_abnormal_extraembryonic_tissu0.65860791
132MP0006072_abnormal_retinal_apoptosis0.65029118
133MP0005397_hematopoietic_system_phenotyp0.64737674
134MP0001545_abnormal_hematopoietic_system0.64737674
135MP0000716_abnormal_immune_system0.64543379
136MP0004147_increased_porphyrin_level0.61113083
137MP0003806_abnormal_nucleotide_metabolis0.60841321
138MP0004197_abnormal_fetal_growth/weight/0.60672524

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)7.05779723
2Abnormal number of erythroid precursors (HP:0012131)6.43947766
3Reticulocytopenia (HP:0001896)6.31233917
4Macrocytic anemia (HP:0001972)4.61977270
5Pallor (HP:0000980)4.39845199
6Birth length less than 3rd percentile (HP:0003561)4.20196607
7Acute necrotizing encephalopathy (HP:0006965)4.05768607
8Increased hepatocellular lipid droplets (HP:0006565)3.89762638
9Mitochondrial inheritance (HP:0001427)3.68582450
10Abnormal mitochondria in muscle tissue (HP:0008316)3.52722875
11Breast hypoplasia (HP:0003187)3.50843569
12Aplastic anemia (HP:0001915)3.41849787
13Oral leukoplakia (HP:0002745)3.36468827
14Decreased activity of mitochondrial respiratory chain (HP:0008972)3.36065626
15Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.36065626
16Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.31671208
17Lipid accumulation in hepatocytes (HP:0006561)3.29810035
18Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.27548258
19Progressive macrocephaly (HP:0004481)3.26205318
20Increased CSF lactate (HP:0002490)3.18682089
21Exertional dyspnea (HP:0002875)3.05902169
22Renal Fanconi syndrome (HP:0001994)3.03101487
23Aplasia/Hypoplasia of the sacrum (HP:0008517)2.99863745
24Acute encephalopathy (HP:0006846)2.97347979
25Abnormality of the labia minora (HP:0012880)2.96166591
26Hepatocellular necrosis (HP:0001404)2.91592986
273-Methylglutaconic aciduria (HP:0003535)2.91022074
28Septo-optic dysplasia (HP:0100842)2.89015567
29Patellar aplasia (HP:0006443)2.85252118
30Methylmalonic acidemia (HP:0002912)2.84857297
31Chromsome breakage (HP:0040012)2.80715494
32Colon cancer (HP:0003003)2.79954414
3311 pairs of ribs (HP:0000878)2.78372816
34Chromosomal breakage induced by crosslinking agents (HP:0003221)2.73753310
35Rough bone trabeculation (HP:0100670)2.71788941
36Aplasia/Hypoplasia of the patella (HP:0006498)2.69042284
37Absent thumb (HP:0009777)2.68979591
38Hyperglycinemia (HP:0002154)2.66921533
39Abnormality of the preputium (HP:0100587)2.62395304
40Carpal bone hypoplasia (HP:0001498)2.57714903
41Respiratory difficulties (HP:0002880)2.53406035
42Increased serum lactate (HP:0002151)2.50882936
43Increased intramyocellular lipid droplets (HP:0012240)2.49686965
44Absent radius (HP:0003974)2.48188658
45Meckel diverticulum (HP:0002245)2.46443093
46Triphalangeal thumb (HP:0001199)2.41122270
47Multiple enchondromatosis (HP:0005701)2.40182404
48Exercise intolerance (HP:0003546)2.39841462
49Abnormality of methionine metabolism (HP:0010901)2.38812171
50Premature graying of hair (HP:0002216)2.38707218
51Hepatic necrosis (HP:0002605)2.37409027
52Cleft eyelid (HP:0000625)2.37073763
53Aplasia involving forearm bones (HP:0009822)2.35558982
54Absent forearm bone (HP:0003953)2.35558982
55Abnormality of the ileum (HP:0001549)2.35240150
56Methylmalonic aciduria (HP:0012120)2.32412003
57Pancreatic fibrosis (HP:0100732)2.30842199
58Pancreatic cysts (HP:0001737)2.29617550
59Abnormal lung lobation (HP:0002101)2.27751263
60Abnormality of chromosome stability (HP:0003220)2.26868744
61Type I transferrin isoform profile (HP:0003642)2.24625061
62Stenosis of the external auditory canal (HP:0000402)2.24610549
63Cerebral hypomyelination (HP:0006808)2.23631926
64Abnormality of the heme biosynthetic pathway (HP:0010472)2.23065506
65Horseshoe kidney (HP:0000085)2.20104627
66Abnormality of serum amino acid levels (HP:0003112)2.19845012
67True hermaphroditism (HP:0010459)2.18428949
68Abnormality of glycolysis (HP:0004366)2.15044363
69Increased serum pyruvate (HP:0003542)2.15044363
70Absent septum pellucidum (HP:0001331)2.13023025
71Abnormal number of incisors (HP:0011064)2.12459301
72Abnormality of midbrain morphology (HP:0002418)2.11763461
73Molar tooth sign on MRI (HP:0002419)2.11763461
74Trismus (HP:0000211)2.10813606
75Depressed nasal ridge (HP:0000457)2.10348953
76Cellular immunodeficiency (HP:0005374)2.09991566
77Aplasia/Hypoplasia of the uvula (HP:0010293)2.09610865
78Microretrognathia (HP:0000308)2.09479852
79Selective tooth agenesis (HP:0001592)2.09168929
80Abnormality of renal resorption (HP:0011038)2.08485983
81Duplicated collecting system (HP:0000081)2.07116927
82Medial flaring of the eyebrow (HP:0010747)2.06704456
83Myelodysplasia (HP:0002863)2.06682579
84Hypoplasia of the radius (HP:0002984)2.06364171
85Supernumerary spleens (HP:0009799)2.06328182
86Abnormality of aspartate family amino acid metabolism (HP:0010899)2.03449897
87Lethargy (HP:0001254)2.02837963
88Abnormal trabecular bone morphology (HP:0100671)2.02705672
89Secondary amenorrhea (HP:0000869)2.01769204
90Nephronophthisis (HP:0000090)2.01578035
91Abnormality of the duodenum (HP:0002246)1.98471590
92Respiratory failure (HP:0002878)1.97971167
93Megaloblastic anemia (HP:0001889)1.97588960
94Abnormality of reticulocytes (HP:0004312)1.96344532
95Small intestinal stenosis (HP:0012848)1.96153939
96Duodenal stenosis (HP:0100867)1.96153939
97Bone marrow hypocellularity (HP:0005528)1.94656738
98Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.93601981
99Lactic acidosis (HP:0003128)1.91748255
100Pancytopenia (HP:0001876)1.91279000
101Glossoptosis (HP:0000162)1.90164276
102Abnormality of the septum pellucidum (HP:0007375)1.89334843
103Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.89010713
104Increased muscle lipid content (HP:0009058)1.87678608
105Abnormality of the renal collecting system (HP:0004742)1.86620346
106Facial cleft (HP:0002006)1.85458337
107Atresia of the external auditory canal (HP:0000413)1.84974501
108Degeneration of anterior horn cells (HP:0002398)1.84336179
109Abnormality of the anterior horn cell (HP:0006802)1.84336179
110Sloping forehead (HP:0000340)1.83940909
111Sparse eyelashes (HP:0000653)1.83904802
112Tracheoesophageal fistula (HP:0002575)1.83337690
113Optic disc pallor (HP:0000543)1.83219515
114Leukodystrophy (HP:0002415)1.83038734
115Sclerocornea (HP:0000647)1.82500862
116Median cleft lip (HP:0000161)1.80186176
117Congenital primary aphakia (HP:0007707)1.79946613
118Abnormality of serine family amino acid metabolism (HP:0010894)1.78592555
119Abnormality of glycine metabolism (HP:0010895)1.78592555
120Short thumb (HP:0009778)1.78367525
121Neoplasm of the pancreas (HP:0002894)1.78005565
122Cerebral edema (HP:0002181)1.77675320
123Premature ovarian failure (HP:0008209)1.76330548
124Hyperglycinuria (HP:0003108)1.76268424
125Volvulus (HP:0002580)1.75590654
126Thrombocytosis (HP:0001894)1.74590418
127CNS demyelination (HP:0007305)1.73031426
128Optic nerve hypoplasia (HP:0000609)1.72882441
129Microvesicular hepatic steatosis (HP:0001414)1.72608100
130Pendular nystagmus (HP:0012043)1.72569378
131Abnormality of alanine metabolism (HP:0010916)1.70856885
132Hyperalaninemia (HP:0003348)1.70856885
133Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.70856885
134Medulloblastoma (HP:0002885)1.70839771
135Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.70216657
136Abnormal protein N-linked glycosylation (HP:0012347)1.70216657
137Abnormal protein glycosylation (HP:0012346)1.70216657
138Abnormal glycosylation (HP:0012345)1.70216657
139X-linked dominant inheritance (HP:0001423)1.70135224
140Agnosia (HP:0010524)1.69838104
141Bifid tongue (HP:0010297)1.69226216
142Hypoplastic pelvis (HP:0008839)1.68974284
143Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.68835121

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.19579667
2WEE14.15972536
3VRK23.73442356
4NME23.67030997
5STK163.49667304
6SRPK13.30460346
7EIF2AK13.07804117
8CDC72.96699336
9VRK12.93649734
10WNK32.36927667
11PLK42.33885910
12EIF2AK32.33019588
13MKNK12.08121313
14DYRK32.04965755
15TRIM282.04877215
16ACVR1B2.01657265
17BRSK21.84076136
18TLK11.81209983
19TAF11.74427570
20NME11.72052054
21PBK1.67058830
22PLK11.66860740
23NUAK11.64824895
24AURKB1.60969351
25NEK21.55250428
26TTK1.54521292
27RPS6KB21.50860494
28TESK21.45323968
29PIM21.40089112
30MAP4K21.37114002
31PLK31.37096720
32CDK71.35702879
33DYRK21.34125600
34MST41.33540663
35CDK81.29974817
36EIF2AK21.25671933
37MKNK21.24569529
38MAP2K71.24038104
39TSSK61.22860435
40ATR1.22796197
41AURKA1.20183487
42CCNB11.20097268
43MAP3K41.18819220
44PASK1.14016797
45ZAK1.13492794
46BRSK11.12225349
47BCKDK1.10024652
48KDR1.08908036
49TGFBR11.06002919
50CSNK1G21.05857639
51LIMK11.04999912
52CHEK21.04631003
53RPS6KA40.92600314
54NEK10.90315530
55GRK10.87599712
56LRRK20.87218249
57IRAK40.87204534
58PAK40.86858708
59CSNK2A10.86473441
60CSNK1A1L0.85684581
61CSNK2A20.83168219
62PLK20.82778850
63MUSK0.80336926
64CASK0.79790221
65CHEK10.78353106
66ILK0.76499543
67MAP3K80.74599332
68STK38L0.73955816
69RPS6KA50.73796093
70MAP3K120.72928442
71EPHA20.71442066
72BRAF0.70215596
73STK40.69076195
74BMPR1B0.69068915
75ABL20.68404130
76PNCK0.66494739
77INSRR0.66128257
78PAK10.60786976
79OXSR10.57792232
80CLK10.57384673
81TEC0.57261937
82CDK30.57211195
83ATM0.56172051
84TESK10.55544815
85YES10.55500025
86PIM10.55148329
87CDK40.53141724
88ERBB30.50257832
89PRKCG0.49357485
90CDK20.48906391
91CSNK1E0.47553615
92CDK190.47275555
93PDK20.47108125
94MAPK130.46372322
95PINK10.46229607
96TNIK0.45052498
97CSNK1G30.44827513
98ADRBK20.44451491
99CDK10.44114416
100STK30.43605650
101LYN0.42736572
102PRKCI0.42344694
103TXK0.42271641
104MINK10.41868252
105BLK0.39254721
106MELK0.36890675
107IRAK30.36875214
108EPHA40.36471992
109BCR0.36382340
110STK100.35931228
111UHMK10.35930758
112MYLK0.35198286
113CSNK1A10.34837011
114MAP3K110.33642350
115IKBKB0.32894988
116IRAK20.32093680
117FGFR10.31681219
118BTK0.29986744
119MAP4K10.29947695
120CDK140.29592615
121ALK0.29481401
122FRK0.27177127
123ERBB40.26898575
124CDK180.26829634
125STK390.26663925
126PRKCE0.26358439
127PRKDC0.25774299
128TIE10.25712959
129PRKACB0.24080779
130MAPKAPK50.23535099
131CSNK1G10.23312290
132KIT0.21589673
133SYK0.21164143
134STK240.19349012
135GRK60.18566574
136ARAF0.18475399
137CDK11A0.17932314
138FLT30.16927816

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.80048771
2Proteasome_Homo sapiens_hsa030504.33213991
3DNA replication_Homo sapiens_hsa030304.17651722
4RNA polymerase_Homo sapiens_hsa030203.94613844
5Mismatch repair_Homo sapiens_hsa034303.68479415
6* Spliceosome_Homo sapiens_hsa030403.24765883
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.03799384
8Pyrimidine metabolism_Homo sapiens_hsa002402.77125265
9Homologous recombination_Homo sapiens_hsa034402.75944778
10Nucleotide excision repair_Homo sapiens_hsa034202.67269734
11Oxidative phosphorylation_Homo sapiens_hsa001902.55139791
12RNA transport_Homo sapiens_hsa030132.45757373
13Base excision repair_Homo sapiens_hsa034102.44999480
14Parkinsons disease_Homo sapiens_hsa050122.42333156
15Huntingtons disease_Homo sapiens_hsa050162.02097357
16Protein export_Homo sapiens_hsa030601.98473249
17Cell cycle_Homo sapiens_hsa041101.98311146
18Fanconi anemia pathway_Homo sapiens_hsa034601.97892500
19Basal transcription factors_Homo sapiens_hsa030221.96201277
20RNA degradation_Homo sapiens_hsa030181.86797728
21Non-homologous end-joining_Homo sapiens_hsa034501.79130414
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.77356814
23One carbon pool by folate_Homo sapiens_hsa006701.67003696
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.59468377
25Alzheimers disease_Homo sapiens_hsa050101.56226968
26Propanoate metabolism_Homo sapiens_hsa006401.49946401
27Purine metabolism_Homo sapiens_hsa002301.45669200
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.43797127
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.40708188
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.27698616
31p53 signaling pathway_Homo sapiens_hsa041151.26173345
32Pyruvate metabolism_Homo sapiens_hsa006201.22456864
33Steroid biosynthesis_Homo sapiens_hsa001001.20542933
34mRNA surveillance pathway_Homo sapiens_hsa030151.19991448
35Epstein-Barr virus infection_Homo sapiens_hsa051691.09154063
36Systemic lupus erythematosus_Homo sapiens_hsa053221.07551993
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.02399984
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.01077721
39Fatty acid elongation_Homo sapiens_hsa000620.88107650
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.84594403
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.82968950
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.74192955
43Butanoate metabolism_Homo sapiens_hsa006500.73984849
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71144638
45Cardiac muscle contraction_Homo sapiens_hsa042600.71103653
46Herpes simplex infection_Homo sapiens_hsa051680.70562788
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.66822174
48Glutathione metabolism_Homo sapiens_hsa004800.64695052
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.64624562
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62851379
51Primary immunodeficiency_Homo sapiens_hsa053400.60371514
52Oocyte meiosis_Homo sapiens_hsa041140.58638341
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57349502
54Antigen processing and presentation_Homo sapiens_hsa046120.55961167
55Carbon metabolism_Homo sapiens_hsa012000.54532435
56Peroxisome_Homo sapiens_hsa041460.54526550
57Folate biosynthesis_Homo sapiens_hsa007900.53038789
58Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51825428
59Viral carcinogenesis_Homo sapiens_hsa052030.51552431
60Graft-versus-host disease_Homo sapiens_hsa053320.50277526
61Drug metabolism - other enzymes_Homo sapiens_hsa009830.50055389
62Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49955551
63Vitamin digestion and absorption_Homo sapiens_hsa049770.47902605
64Allograft rejection_Homo sapiens_hsa053300.47628403
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47445998
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42786292
67Asthma_Homo sapiens_hsa053100.42377493
68Legionellosis_Homo sapiens_hsa051340.42333206
69Arachidonic acid metabolism_Homo sapiens_hsa005900.42239841
70Tryptophan metabolism_Homo sapiens_hsa003800.42211179
71Metabolic pathways_Homo sapiens_hsa011000.41882887
72Sulfur relay system_Homo sapiens_hsa041220.41621098
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.41618319
74HTLV-I infection_Homo sapiens_hsa051660.40380155
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40281471
76Chemical carcinogenesis_Homo sapiens_hsa052040.40090740
77Alcoholism_Homo sapiens_hsa050340.39557476
78Sulfur metabolism_Homo sapiens_hsa009200.39495848
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38299635
80Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36453879
81beta-Alanine metabolism_Homo sapiens_hsa004100.36346525
82Hematopoietic cell lineage_Homo sapiens_hsa046400.36298371
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.36209503
84Pentose phosphate pathway_Homo sapiens_hsa000300.36145647
85Caffeine metabolism_Homo sapiens_hsa002320.35587426
86Intestinal immune network for IgA production_Homo sapiens_hsa046720.32768120
87Nitrogen metabolism_Homo sapiens_hsa009100.32092568
88Nicotine addiction_Homo sapiens_hsa050330.32092051
89Collecting duct acid secretion_Homo sapiens_hsa049660.31001901
90Retinol metabolism_Homo sapiens_hsa008300.30434344
91TGF-beta signaling pathway_Homo sapiens_hsa043500.30244332
92Autoimmune thyroid disease_Homo sapiens_hsa053200.29777988
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28695142
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.27544444
95N-Glycan biosynthesis_Homo sapiens_hsa005100.27432511
96Cyanoamino acid metabolism_Homo sapiens_hsa004600.26579703
97Arginine and proline metabolism_Homo sapiens_hsa003300.25528048
98Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.25234019
99Measles_Homo sapiens_hsa051620.24988679
100Fatty acid degradation_Homo sapiens_hsa000710.24875933
101Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23232842
102NF-kappa B signaling pathway_Homo sapiens_hsa040640.23005406
103Basal cell carcinoma_Homo sapiens_hsa052170.22547550
104Apoptosis_Homo sapiens_hsa042100.22229636
105Maturity onset diabetes of the young_Homo sapiens_hsa049500.22092214
106Wnt signaling pathway_Homo sapiens_hsa043100.21761063
107Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.20425177
108Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.20312181
109Small cell lung cancer_Homo sapiens_hsa052220.19688908
110Fatty acid metabolism_Homo sapiens_hsa012120.19512592
111NOD-like receptor signaling pathway_Homo sapiens_hsa046210.18595291
112Olfactory transduction_Homo sapiens_hsa047400.18401144
113Primary bile acid biosynthesis_Homo sapiens_hsa001200.18247369
114Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.17543855
115Tyrosine metabolism_Homo sapiens_hsa003500.17482360
116Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.17459574
117RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.17325462
118Taste transduction_Homo sapiens_hsa047420.17311656
119Shigellosis_Homo sapiens_hsa051310.14863025
120MicroRNAs in cancer_Homo sapiens_hsa052060.14638489
121Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.14593938
122Steroid hormone biosynthesis_Homo sapiens_hsa001400.13757291
123Hepatitis B_Homo sapiens_hsa051610.13257819
124Vitamin B6 metabolism_Homo sapiens_hsa007500.11634363
125Hedgehog signaling pathway_Homo sapiens_hsa043400.11528463
126Linoleic acid metabolism_Homo sapiens_hsa005910.11178115
127Thyroid cancer_Homo sapiens_hsa052160.10884656
128Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.10856342
129Viral myocarditis_Homo sapiens_hsa054160.09683959
130Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.09477149
131Pathways in cancer_Homo sapiens_hsa052000.09412720
132Colorectal cancer_Homo sapiens_hsa052100.09119601
133Type I diabetes mellitus_Homo sapiens_hsa049400.08903417
134Phototransduction_Homo sapiens_hsa047440.08726460
135Renin-angiotensin system_Homo sapiens_hsa046140.06490693
136Ether lipid metabolism_Homo sapiens_hsa005650.06370253
137Notch signaling pathway_Homo sapiens_hsa043300.04953588
138Selenocompound metabolism_Homo sapiens_hsa004500.04304719
139Regulation of autophagy_Homo sapiens_hsa041400.03914495
140Biosynthesis of amino acids_Homo sapiens_hsa012300.03388209
141Hippo signaling pathway_Homo sapiens_hsa043900.03295714
142Influenza A_Homo sapiens_hsa051640.02750986

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