ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	tryptophan catabolic process (GO:0006569)	5.76514929
2	indole-containing compound catabolic process (GO:0042436)	5.76514929
3	indolalkylamine catabolic process (GO:0046218)	5.76514929
4	tryptophan metabolic process (GO:0006568)	5.51351916
5	kynurenine metabolic process (GO:0070189)	5.45292220
6	protein complex biogenesis (GO:0070271)	5.33962546
7	mitochondrial respiratory chain complex assembly (GO:0033108)	4.91013212
8	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	4.86455997
9	respiratory chain complex IV assembly (GO:0008535)	4.57179894
10	protein neddylation (GO:0045116)	4.32806061
11	protein-cofactor linkage (GO:0018065)	4.31209867
12	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.18968505
13	indolalkylamine metabolic process (GO:0006586)	4.12432033
14	sequestering of actin monomers (GO:0042989)	4.12091278
15	platelet dense granule organization (GO:0060155)	4.09672021
16	negative regulation of heart rate (GO:0010459)	4.05592783
17	cytochrome complex assembly (GO:0017004)	3.99724237
18	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.98403491
19	NADH dehydrogenase complex assembly (GO:0010257)	3.95596621
20	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.95596621
21	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.95596621
22	magnesium ion transport (GO:0015693)	3.91043965
23	cellular biogenic amine catabolic process (GO:0042402)	3.74006922
24	amine catabolic process (GO:0009310)	3.74006922
25	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.72445507
26	ATP synthesis coupled proton transport (GO:0015986)	3.72445507
27	GTP biosynthetic process (GO:0006183)	3.58760797
28	electron transport chain (GO:0022900)	3.47368862
29	respiratory electron transport chain (GO:0022904)	3.44320530
30	mitochondrial calcium ion transport (GO:0006851)	3.42149823
31	regulation of meiosis I (GO:0060631)	3.34629938
32	aggressive behavior (GO:0002118)	3.33878861
33	purine-containing compound salvage (GO:0043101)	3.31032934
34	pyrimidine nucleotide catabolic process (GO:0006244)	3.30201180
35	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.29515954
36	lysine metabolic process (GO:0006553)	3.27739197
37	lysine catabolic process (GO:0006554)	3.27739197
38	base-excision repair, AP site formation (GO:0006285)	3.22618536
39	peptidyl-histidine modification (GO:0018202)	3.22196175
40	iron-sulfur cluster assembly (GO:0016226)	3.18765577
41	metallo-sulfur cluster assembly (GO:0031163)	3.18765577
42	rRNA methylation (GO:0031167)	3.18391203
43	adenosine metabolic process (GO:0046085)	3.03176919
44	adaptation of signaling pathway (GO:0023058)	3.02968087
45	rRNA modification (GO:0000154)	3.02346764
46	regulation of rhodopsin mediated signaling pathway (GO:0022400)	3.00456727
47	DNA double-strand break processing (GO:0000729)	3.00219122
48	negative regulation of amino acid transport (GO:0051956)	2.99989085
49	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.99679157
50	aromatic amino acid family catabolic process (GO:0009074)	2.99654316
51	ribosomal small subunit assembly (GO:0000028)	2.98553015
52	auditory receptor cell stereocilium organization (GO:0060088)	2.97945122
53	multicellular organism reproduction (GO:0032504)	2.97892506
54	UTP biosynthetic process (GO:0006228)	2.93915345
55	regulation of mitochondrial translation (GO:0070129)	2.91410003
56	UTP metabolic process (GO:0046051)	2.90931743
57	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.90403788
58	deoxyribose phosphate biosynthetic process (GO:0046385)	2.88781872
59	2-deoxyribonucleotide biosynthetic process (GO:0009265)	2.88781872
60	purine nucleotide salvage (GO:0032261)	2.87511763
61	regulation of transmission of nerve impulse (GO:0051969)	2.85643416
62	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.82784166
63	aspartate family amino acid catabolic process (GO:0009068)	2.81712785
64	neural tube formation (GO:0001841)	2.80089950
65	detection of light stimulus involved in visual perception (GO:0050908)	2.79903434
66	detection of light stimulus involved in sensory perception (GO:0050962)	2.79903434
67	indole-containing compound metabolic process (GO:0042430)	2.78382491
68	C4-dicarboxylate transport (GO:0015740)	2.76604877
69	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.75153625
70	preassembly of GPI anchor in ER membrane (GO:0016254)	2.74488515
71	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.72787520
72	water-soluble vitamin biosynthetic process (GO:0042364)	2.71391848
73	molting cycle (GO:0042303)	2.71057356
74	hair cycle (GO:0042633)	2.71057356
75	tongue development (GO:0043586)	2.69537123
76	protein polyglutamylation (GO:0018095)	2.69385510
77	negative regulation of multicellular organism growth (GO:0040015)	2.68994593
78	rhodopsin mediated signaling pathway (GO:0016056)	2.67665034
79	spliceosomal complex assembly (GO:0000245)	2.67485802
80	interferon-gamma production (GO:0032609)	2.65080712
81	cornea development in camera-type eye (GO:0061303)	2.64756477
82	righting reflex (GO:0060013)	2.63954560
83	viral transcription (GO:0019083)	2.62174223
84	reflex (GO:0060004)	2.61987148
85	negative regulation of neurological system process (GO:0031645)	2.61170808
86	benzene-containing compound metabolic process (GO:0042537)	2.60981457
87	deoxyribonucleotide catabolic process (GO:0009264)	2.60771095
88	DNA deamination (GO:0045006)	2.57869672
89	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.57212227
90	translational termination (GO:0006415)	2.57019110
91	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.56311240
92	forebrain neuron differentiation (GO:0021879)	2.56103454
93	negative regulation of astrocyte differentiation (GO:0048712)	2.53820865
94	behavioral response to nicotine (GO:0035095)	2.53580816
95	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.50730883
96	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.50730883
97	positive regulation of protein homodimerization activity (GO:0090073)	2.50087465
98	regulation of cellular amino acid metabolic process (GO:0006521)	2.49864182
99	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.49419739
100	C-terminal protein lipidation (GO:0006501)	2.48566893

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	5.68017928
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.45136984
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.39410402
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.34083410
5	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.25699740
6	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.13989113
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.99690678
8	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.84129350
9	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.79646504
10	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.65210856
11	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.64619259
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.54332191
13	IGF1R_20145208_ChIP-Seq_DFB_Human	2.47081505
14	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.42958260
15	ZNF274_21170338_ChIP-Seq_K562_Hela	2.32731415
16	EWS_26573619_Chip-Seq_HEK293_Human	2.19348937
17	VDR_23849224_ChIP-Seq_CD4+_Human	2.14389242
18	ELK1_19687146_ChIP-ChIP_HELA_Human	2.08209159
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.07836556
20	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.04514215
21	FOXP3_21729870_ChIP-Seq_TREG_Human	2.03091209
22	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.01358170
23	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.98969017
24	MYC_18940864_ChIP-ChIP_HL60_Human	1.92236558
25	TAF15_26573619_Chip-Seq_HEK293_Human	1.89545303
26	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.87793059
27	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.81323037
28	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.71781875
29	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.70399129
30	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.65058074
31	FUS_26573619_Chip-Seq_HEK293_Human	1.64972689
32	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.56293642
33	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.49702193
34	RNF2_27304074_Chip-Seq_NSC_Mouse	1.47805653
35	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.45733011
36	TP53_22573176_ChIP-Seq_HFKS_Human	1.43566665
37	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.41533112
38	VDR_22108803_ChIP-Seq_LS180_Human	1.40927594
39	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.37992154
40	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.34816200
41	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.32221407
42	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.32221407
43	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.28690676
44	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.26588943
45	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.25976745
46	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.25155102
47	NANOG_19829295_ChIP-Seq_ESCs_Human	1.25084387
48	SOX2_19829295_ChIP-Seq_ESCs_Human	1.25084387
49	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.24089318
50	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.24086709
51	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.21533938
52	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.20634107
53	ER_23166858_ChIP-Seq_MCF-7_Human	1.20599960
54	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.20268128
55	P300_19829295_ChIP-Seq_ESCs_Human	1.19465025
56	HTT_18923047_ChIP-ChIP_STHdh_Human	1.18551727
57	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.17686758
58	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.16873712
59	AR_20517297_ChIP-Seq_VCAP_Human	1.16302194
60	NCOR_22424771_ChIP-Seq_293T_Human	1.16118933
61	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.15891150
62	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.15429305
63	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.15183310
64	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.14058824
65	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.12792490
66	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.12571453
67	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.11552285
68	CBP_20019798_ChIP-Seq_JUKART_Human	1.09712414
69	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.09712414
70	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.08055712
71	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.05086481
72	MYB_26560356_Chip-Seq_TH2_Human	1.03239530
73	IRF1_19129219_ChIP-ChIP_H3396_Human	1.02837562
74	GABP_19822575_ChIP-Seq_HepG2_Human	1.02779656
75	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.02531857
76	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.99985455
77	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.99488966
78	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.99175250
79	GATA3_26560356_Chip-Seq_TH2_Human	0.99110761
80	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.98848351
81	TAF2_19829295_ChIP-Seq_ESCs_Human	0.98833371
82	RBPJ_21746931_ChIP-Seq_IB4_Human	0.97961071
83	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.97893347
84	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.96969941
85	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.94921189
86	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.94611405
87	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.92462690
88	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.92171250
89	NANOG_20526341_ChIP-Seq_ESCs_Human	0.91283797
90	ETV1_20927104_ChIP-Seq_GIST48_Human	0.90769210
91	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.89789507
92	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.89711101
93	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.89042233
94	IRF8_21731497_ChIP-ChIP_J774_Mouse	0.88524212
95	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.85794265
96	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.85345026
97	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.85142250
98	AR_25329375_ChIP-Seq_VCAP_Human	0.84965949
99	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.84763364
100	EZH2_22144423_ChIP-Seq_EOC_Human	0.84617790

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003646_muscle_fatigue	4.14230159
2	MP0000372_irregular_coat_pigmentation	3.95329840
3	MP0003011_delayed_dark_adaptation	3.22753439
4	MP0005377_hearing/vestibular/ear_phenot	3.15567352
5	MP0003878_abnormal_ear_physiology	3.15567352
6	MP0002102_abnormal_ear_morphology	3.07463624
7	MP0005645_abnormal_hypothalamus_physiol	2.92696206
8	MP0006292_abnormal_olfactory_placode	2.50147126
9	MP0005075_abnormal_melanosome_morpholog	2.48223685
10	MP0003183_abnormal_peptide_metabolism	2.45614190
11	MP0005551_abnormal_eye_electrophysiolog	2.43415055
12	MP0002837_dystrophic_cardiac_calcinosis	2.28249084
13	MP0009379_abnormal_foot_pigmentation	2.25894177
14	MP0002234_abnormal_pharynx_morphology	2.21334283
15	MP0010386_abnormal_urinary_bladder	2.13413175
16	MP0005646_abnormal_pituitary_gland	2.06471592
17	MP0005410_abnormal_fertilization	2.06466838
18	MP0005253_abnormal_eye_physiology	1.98946295
19	MP0008872_abnormal_physiological_respon	1.68231234
20	MP0002138_abnormal_hepatobiliary_system	1.68158199
21	MP0009046_muscle_twitch	1.66754908
22	MP0001293_anophthalmia	1.65897278
23	MP0006276_abnormal_autonomic_nervous	1.62481025
24	MP0006036_abnormal_mitochondrial_physio	1.61423257
25	MP0005671_abnormal_response_to	1.60331893
26	MP0000631_abnormal_neuroendocrine_gland	1.55223387
27	MP0001485_abnormal_pinna_reflex	1.54582663
28	MP0008877_abnormal_DNA_methylation	1.54066099
29	MP0002638_abnormal_pupillary_reflex	1.53097497
30	MP0002272_abnormal_nervous_system	1.50640653
31	MP0004381_abnormal_hair_follicle	1.47232304
32	MP0001486_abnormal_startle_reflex	1.39676151
33	MP0001905_abnormal_dopamine_level	1.36332048
34	MP0001984_abnormal_olfaction	1.35044636
35	MP0001963_abnormal_hearing_physiology	1.34147193
36	MP0008995_early_reproductive_senescence	1.32189342
37	MP0004142_abnormal_muscle_tone	1.27148506
38	MP0000538_abnormal_urinary_bladder	1.25084912
39	MP0003786_premature_aging	1.22319526
40	MP0008875_abnormal_xenobiotic_pharmacok	1.16890566
41	MP0003724_increased_susceptibility_to	1.14443101
42	MP0000026_abnormal_inner_ear	1.13861320
43	MP0005084_abnormal_gallbladder_morpholo	1.13683696
44	MP0002733_abnormal_thermal_nociception	1.10362908
45	MP0006072_abnormal_retinal_apoptosis	1.09470425
46	MP0002090_abnormal_vision	1.07630838
47	MP0001970_abnormal_pain_threshold	1.06384889
48	MP0001764_abnormal_homeostasis	1.06289838
49	MP0005391_vision/eye_phenotype	1.04829475
50	MP0003252_abnormal_bile_duct	1.03954261
51	MP0009785_altered_susceptibility_to	1.02217394
52	MP0002736_abnormal_nociception_after	1.02197581
53	MP0000604_amyloidosis	1.01461762
54	MP0002148_abnormal_hypersensitivity_rea	1.01134334
55	MP0008058_abnormal_DNA_repair	0.98492861
56	MP0002653_abnormal_ependyma_morphology	0.96107434
57	MP0005167_abnormal_blood-brain_barrier	0.95884855
58	MP0002928_abnormal_bile_duct	0.95358730
59	MP0000049_abnormal_middle_ear	0.93492737
60	MP0009780_abnormal_chondrocyte_physiolo	0.91795659
61	MP0004043_abnormal_pH_regulation	0.90962170
62	MP0002751_abnormal_autonomic_nervous	0.90487990
63	MP0004742_abnormal_vestibular_system	0.88459466
64	MP0003137_abnormal_impulse_conducting	0.88257921
65	MP0002269_muscular_atrophy	0.87718064
66	MP0002752_abnormal_somatic_nervous	0.86046234
67	MP0009333_abnormal_splenocyte_physiolog	0.85605483
68	MP0003880_abnormal_central_pattern	0.85518738
69	MP0002067_abnormal_sensory_capabilities	0.84850994
70	MP0000613_abnormal_salivary_gland	0.82009920
71	MP0005332_abnormal_amino_acid	0.80233161
72	MP0005171_absent_coat_pigmentation	0.79189417
73	MP0005195_abnormal_posterior_eye	0.77920852
74	MP0004215_abnormal_myocardial_fiber	0.76987771
75	MP0009697_abnormal_copulation	0.75640649
76	MP0002184_abnormal_innervation	0.75530693
77	MP0002229_neurodegeneration	0.74103321
78	MP0000639_abnormal_adrenal_gland	0.73997090
79	MP0002693_abnormal_pancreas_physiology	0.72465081
80	MP0002277_abnormal_respiratory_mucosa	0.72320415
81	MP0001968_abnormal_touch/_nociception	0.71355574
82	MP0002876_abnormal_thyroid_physiology	0.71061197
83	MP0003936_abnormal_reproductive_system	0.69835824
84	MP0003806_abnormal_nucleotide_metabolis	0.69484155
85	MP0002822_catalepsy	0.68516328
86	MP0000653_abnormal_sex_gland	0.66250562
87	MP0002734_abnormal_mechanical_nocicepti	0.65782956
88	MP0001243_abnormal_dermal_layer	0.65218632
89	MP0000569_abnormal_digit_pigmentation	0.64389397
90	MP0001119_abnormal_female_reproductive	0.64320999
91	MP0002210_abnormal_sex_determination	0.64057612
92	MP0003119_abnormal_digestive_system	0.63233686
93	MP0001542_abnormal_bone_strength	0.61860735
94	MP0005636_abnormal_mineral_homeostasis	0.61296529
95	MP0003718_maternal_effect	0.61122932
96	MP0003633_abnormal_nervous_system	0.59521454
97	MP0002282_abnormal_trachea_morphology	0.58663090
98	MP0003186_abnormal_redox_activity	0.58309277
99	MP0003195_calcinosis	0.57537650
100	MP0009745_abnormal_behavioral_response	0.56993179

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Increased intramyocellular lipid droplets (HP:0012240)	4.64461070
2	Abnormal mitochondria in muscle tissue (HP:0008316)	4.58924699
3	Methylmalonic acidemia (HP:0002912)	4.32404253
4	Acute necrotizing encephalopathy (HP:0006965)	4.24705214
5	Decreased central vision (HP:0007663)	4.20760752
6	Increased muscle lipid content (HP:0009058)	4.19813338
7	Lipid accumulation in hepatocytes (HP:0006561)	4.01972415
8	Acute encephalopathy (HP:0006846)	3.97176879
9	Aplastic anemia (HP:0001915)	3.96810064
10	Mitochondrial inheritance (HP:0001427)	3.95862526
11	Increased hepatocellular lipid droplets (HP:0006565)	3.84839823
12	Progressive macrocephaly (HP:0004481)	3.64480959
13	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.63456615
14	Increased CSF lactate (HP:0002490)	3.44802412
15	Pancreatic fibrosis (HP:0100732)	3.39862086
16	Renal cortical cysts (HP:0000803)	3.38784045
17	Hyperglycinemia (HP:0002154)	3.35592990
18	Abnormality of the renal cortex (HP:0011035)	3.29933346
19	Pancreatic cysts (HP:0001737)	3.26026491
20	Pigmentary retinal degeneration (HP:0001146)	3.23816973
21	Methylmalonic aciduria (HP:0012120)	3.17806631
22	Congenital, generalized hypertrichosis (HP:0004540)	3.15466171
23	Congenital stationary night blindness (HP:0007642)	3.14151142
24	Hepatocellular necrosis (HP:0001404)	3.02631020
25	Abnormality of midbrain morphology (HP:0002418)	3.02218365
26	Molar tooth sign on MRI (HP:0002419)	3.02218365
27	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.97615409
28	Abnormal rod and cone electroretinograms (HP:0008323)	2.93387268
29	Spastic paraparesis (HP:0002313)	2.88700045
30	Cerebral edema (HP:0002181)	2.80814987
31	Keratoconus (HP:0000563)	2.78936290
32	Increased corneal curvature (HP:0100692)	2.78936290
33	Renal Fanconi syndrome (HP:0001994)	2.78844383
34	True hermaphroditism (HP:0010459)	2.78503598
35	Hepatic necrosis (HP:0002605)	2.73256503
36	Nephronophthisis (HP:0000090)	2.73061007
37	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.68256647
38	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.65792863
39	Abolished electroretinogram (ERG) (HP:0000550)	2.63863072
40	Tubular atrophy (HP:0000092)	2.63513515
41	Supernumerary spleens (HP:0009799)	2.61165015
42	Attenuation of retinal blood vessels (HP:0007843)	2.60932598
43	Type II lissencephaly (HP:0007260)	2.54666804
44	Abnormality of vitamin B metabolism (HP:0004340)	2.52731974
45	Medial flaring of the eyebrow (HP:0010747)	2.49741282
46	Abnormality of serum amino acid levels (HP:0003112)	2.49664814
47	Leukodystrophy (HP:0002415)	2.48838321
48	Polydipsia (HP:0001959)	2.43240691
49	Abnormal drinking behavior (HP:0030082)	2.43240691
50	Short tibia (HP:0005736)	2.41622164
51	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.40929312
52	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.39580742
53	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.39580742
54	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.33164617
55	Hypoproteinemia (HP:0003075)	2.30229348
56	Severe combined immunodeficiency (HP:0004430)	2.30184768
57	Abnormality of B cell number (HP:0010975)	2.26417148
58	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.25752696
59	Abnormality of the renal medulla (HP:0100957)	2.25613865
60	Abnormality of glycine metabolism (HP:0010895)	2.24021604
61	Abnormality of serine family amino acid metabolism (HP:0010894)	2.24021604
62	Chronic hepatic failure (HP:0100626)	2.21640962
63	B lymphocytopenia (HP:0010976)	2.21214176
64	Optic disc pallor (HP:0000543)	2.21133458
65	Exercise intolerance (HP:0003546)	2.18585182
66	Type I transferrin isoform profile (HP:0003642)	2.16912393
67	Type 2 muscle fiber atrophy (HP:0003554)	2.16299625
68	Lactic acidosis (HP:0003128)	2.15538057
69	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.13991237
70	Dicarboxylic aciduria (HP:0003215)	2.13991237
71	Exertional dyspnea (HP:0002875)	2.13631350
72	Chorioretinal atrophy (HP:0000533)	2.12916624
73	Reduced antithrombin III activity (HP:0001976)	2.12728644
74	Respiratory failure (HP:0002878)	2.10540639
75	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.09972367
76	Abnormality of macular pigmentation (HP:0008002)	2.08009789
77	Focal motor seizures (HP:0011153)	2.04041051
78	3-Methylglutaconic aciduria (HP:0003535)	2.03762862
79	Lethargy (HP:0001254)	2.01900930
80	Thyroiditis (HP:0100646)	1.99825295
81	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.97057832
82	Meckel diverticulum (HP:0002245)	1.96424956
83	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.94539014
84	Cystic liver disease (HP:0006706)	1.93772679
85	Increased serum lactate (HP:0002151)	1.89925338
86	Abnormality of the ileum (HP:0001549)	1.89276231
87	Delayed CNS myelination (HP:0002188)	1.87908171
88	Hyperglycinuria (HP:0003108)	1.87577865
89	Chronic diarrhea (HP:0002028)	1.86549770
90	Polyuria (HP:0000103)	1.83674674
91	Bony spicule pigmentary retinopathy (HP:0007737)	1.83040597
92	Congenital primary aphakia (HP:0007707)	1.82506341
93	Neonatal respiratory distress (HP:0002643)	1.79986612
94	Gait imbalance (HP:0002141)	1.79333129
95	Mesangial abnormality (HP:0001966)	1.78557856
96	Asplenia (HP:0001746)	1.78553556
97	IgG deficiency (HP:0004315)	1.77163003
98	Postaxial hand polydactyly (HP:0001162)	1.76765167
99	Combined immunodeficiency (HP:0005387)	1.72855339
100	Pancytopenia (HP:0001876)	1.71914076

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	6.02658737
2	SCYL2	5.18957946
3	STK16	4.12165102
4	TAOK3	2.62847919
5	ADRBK2	2.32570433
6	MAP4K2	2.28254433
7	MAP4K1	2.24380377
8	STK38L	2.15843908
9	NEK1	2.10053807
10	MAP3K12	2.09674960
11	ZAK	2.08872244
12	WNK3	2.08194371
13	PASK	1.97631361
14	STK24	1.94668879
15	BUB1	1.93288317
16	BCKDK	1.69383992
17	MAP3K11	1.68671267
18	PINK1	1.63990363
19	MKNK1	1.63214207
20	NLK	1.52453472
21	FRK	1.43960456
22	INSRR	1.42580537
23	FES	1.41608564
24	MST4	1.40689992
25	ERBB3	1.38551149
26	NUAK1	1.28830583
27	GRK1	1.27448161
28	MAPKAPK5	1.25542016
29	MAPKAPK3	1.17541163
30	MAPK13	1.10914702
31	OXSR1	1.09063926
32	MAP3K3	1.04486780
33	KDR	1.04410876
34	IKBKE	0.97993532
35	TLK1	0.96394948
36	MAP2K7	0.89561883
37	MAP2K3	0.87832676
38	TIE1	0.86920984
39	BRSK2	0.85999741
40	MATK	0.81265702
41	TNK2	0.80140903
42	TAF1	0.76470476
43	EIF2AK3	0.74428452
44	MAP3K4	0.73933232
45	RPS6KA5	0.67986054
46	NME2	0.67108612
47	MAP2K6	0.64558265
48	PRKCQ	0.64061371
49	CSNK1G3	0.63732787
50	TRPM7	0.63478311
51	ADRBK1	0.63040211
52	DYRK1B	0.60118611
53	DAPK1	0.59282866
54	TNIK	0.58438026
55	PHKG2	0.58415837
56	PHKG1	0.58415837
57	ITK	0.57907653
58	PLK1	0.56893503
59	CAMKK1	0.56719374
60	PIK3CA	0.55668196
61	STK39	0.54688670
62	MAP2K4	0.50854432
63	CDK19	0.49558030
64	IGF1R	0.49206308
65	OBSCN	0.49203057
66	BRSK1	0.49095592
67	WNK4	0.48883613
68	CSNK1G1	0.47163427
69	CSNK1G2	0.46970334
70	NEK2	0.44704300
71	CAMK2A	0.44344061
72	FER	0.44233258
73	CSNK2A1	0.42797709
74	PTK2B	0.42027131
75	ABL2	0.41002680
76	VRK2	0.40752245
77	MAP3K5	0.40367251
78	GRK7	0.40312845
79	PAK3	0.39234033
80	DAPK2	0.38638392
81	IKBKB	0.38309219
82	LYN	0.38006751
83	EPHA4	0.37327004
84	MAPK15	0.37123805
85	CSNK1A1L	0.35246717
86	CSF1R	0.34281844
87	VRK1	0.34280626
88	BTK	0.33949373
89	TEC	0.33759189
90	SYK	0.33405890
91	MYLK	0.32908567
92	PRKACA	0.32408834
93	MINK1	0.32199855
94	CASK	0.31707364
95	KIT	0.30659895
96	LCK	0.29795032
97	JAK3	0.29676023
98	DYRK2	0.29475843
99	PRKCA	0.28655505
100	UHMK1	0.28194892

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.70459989
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.52185711
3	Ribosome_Homo sapiens_hsa03010	3.48243026
4	One carbon pool by folate_Homo sapiens_hsa00670	3.21939484
5	Phototransduction_Homo sapiens_hsa04744	3.08429607
6	Parkinsons disease_Homo sapiens_hsa05012	2.69094823
7	RNA polymerase_Homo sapiens_hsa03020	2.55122458
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.44550119
9	Protein export_Homo sapiens_hsa03060	2.42559358
10	Primary immunodeficiency_Homo sapiens_hsa05340	2.22069313
11	Nitrogen metabolism_Homo sapiens_hsa00910	2.12785176
12	Homologous recombination_Homo sapiens_hsa03440	1.89050287
13	Mismatch repair_Homo sapiens_hsa03430	1.81807851
14	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.73301558
15	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.67970799
16	Tryptophan metabolism_Homo sapiens_hsa00380	1.67262068
17	Huntingtons disease_Homo sapiens_hsa05016	1.67201114
18	Cardiac muscle contraction_Homo sapiens_hsa04260	1.66113810
19	Fanconi anemia pathway_Homo sapiens_hsa03460	1.64397447
20	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.64166403
21	Alzheimers disease_Homo sapiens_hsa05010	1.62662512
22	Pyrimidine metabolism_Homo sapiens_hsa00240	1.58923547
23	Purine metabolism_Homo sapiens_hsa00230	1.52255184
24	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.49124493
25	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.42044181
26	Propanoate metabolism_Homo sapiens_hsa00640	1.38742807
27	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.36555231
28	Antigen processing and presentation_Homo sapiens_hsa04612	1.35065470
29	RNA degradation_Homo sapiens_hsa03018	1.35059909
30	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.29797093
31	Olfactory transduction_Homo sapiens_hsa04740	1.26723289
32	Base excision repair_Homo sapiens_hsa03410	1.25136498
33	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.24622894
34	Spliceosome_Homo sapiens_hsa03040	1.22990813
35	Graft-versus-host disease_Homo sapiens_hsa05332	1.18738853
36	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.18299315
37	Nucleotide excision repair_Homo sapiens_hsa03420	1.17605171
38	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.17103956
39	Linoleic acid metabolism_Homo sapiens_hsa00591	1.13676223
40	Chemical carcinogenesis_Homo sapiens_hsa05204	1.09062535
41	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.06478854
42	Butanoate metabolism_Homo sapiens_hsa00650	1.06130760
43	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.03593046
44	Malaria_Homo sapiens_hsa05144	1.00758908
45	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.99892462
46	Peroxisome_Homo sapiens_hsa04146	0.98796645
47	Retinol metabolism_Homo sapiens_hsa00830	0.94635349
48	Basal transcription factors_Homo sapiens_hsa03022	0.93779653
49	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.92716242
50	Allograft rejection_Homo sapiens_hsa05330	0.91731453
51	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.90804800
52	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.90171845
53	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.89915453
54	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.89311202
55	Caffeine metabolism_Homo sapiens_hsa00232	0.82226583
56	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.81848992
57	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.80053820
58	DNA replication_Homo sapiens_hsa03030	0.79918593
59	Metabolic pathways_Homo sapiens_hsa01100	0.79911215
60	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.79576406
61	Glutathione metabolism_Homo sapiens_hsa00480	0.78335781
62	Taste transduction_Homo sapiens_hsa04742	0.78255044
63	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.77341006
64	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.75194075
65	Type I diabetes mellitus_Homo sapiens_hsa04940	0.69610465
66	Fatty acid elongation_Homo sapiens_hsa00062	0.68085282
67	Regulation of autophagy_Homo sapiens_hsa04140	0.65159800
68	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.62762634
69	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.61719046
70	Collecting duct acid secretion_Homo sapiens_hsa04966	0.59921094
71	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.54712171
72	Morphine addiction_Homo sapiens_hsa05032	0.54308426
73	Steroid biosynthesis_Homo sapiens_hsa00100	0.53653819
74	Nicotine addiction_Homo sapiens_hsa05033	0.52948091
75	Salivary secretion_Homo sapiens_hsa04970	0.51171895
76	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.49592682
77	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.48040571
78	Ether lipid metabolism_Homo sapiens_hsa00565	0.46336917
79	Glycerolipid metabolism_Homo sapiens_hsa00561	0.45988634
80	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.42142521
81	RNA transport_Homo sapiens_hsa03013	0.42068369
82	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.40904306
83	Asthma_Homo sapiens_hsa05310	0.39383634
84	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.38663892
85	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.38625755
86	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.38007125
87	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.35426976
88	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.32326581
89	Tyrosine metabolism_Homo sapiens_hsa00350	0.31217256
90	Mineral absorption_Homo sapiens_hsa04978	0.30823835
91	Basal cell carcinoma_Homo sapiens_hsa05217	0.30753137
92	Selenocompound metabolism_Homo sapiens_hsa00450	0.30006430
93	Renin secretion_Homo sapiens_hsa04924	0.29880602
94	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.28892030
95	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.26858010
96	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.24819771
97	Fat digestion and absorption_Homo sapiens_hsa04975	0.23543618
98	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.20773038
99	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.20552126
100	Non-homologous end-joining_Homo sapiens_hsa03450	0.19828813

SNRPEP10

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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