ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.15858596
2	ATP synthesis coupled proton transport (GO:0015986)	5.10162469
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.10162469
4	ribonucleoprotein complex disassembly (GO:0032988)	5.09718867
5	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.95199265
6	response to pheromone (GO:0019236)	4.55495965
7	organelle disassembly (GO:1903008)	4.46329062
8	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.44467814
9	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.44467814
10	NADH dehydrogenase complex assembly (GO:0010257)	4.44467814
11	protein complex biogenesis (GO:0070271)	4.37780141
12	intraciliary transport (GO:0042073)	4.35818752
13	platelet dense granule organization (GO:0060155)	4.34552745
14	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	4.28776995
15	protein localization to cilium (GO:0061512)	4.18347340
16	respiratory electron transport chain (GO:0022904)	4.18228874
17	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	4.16435745
18	electron transport chain (GO:0022900)	4.13955771
19	maturation of 5.8S rRNA (GO:0000460)	3.95501400
20	mitochondrial respiratory chain complex assembly (GO:0033108)	3.83918007
21	piRNA metabolic process (GO:0034587)	3.74552284
22	aldehyde catabolic process (GO:0046185)	3.62875015
23	respiratory chain complex IV assembly (GO:0008535)	3.56972556
24	protein-cofactor linkage (GO:0018065)	3.53626949
25	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.51614579
26	ribosomal large subunit biogenesis (GO:0042273)	3.49639264
27	behavioral response to nicotine (GO:0035095)	3.47332061
28	chaperone-mediated protein transport (GO:0072321)	3.42528932
29	neural tube formation (GO:0001841)	3.34418148
30	cytochrome complex assembly (GO:0017004)	3.26029700
31	rRNA methylation (GO:0031167)	3.21753174
32	lactate metabolic process (GO:0006089)	3.19278365
33	auditory receptor cell stereocilium organization (GO:0060088)	3.18893821
34	DNA deamination (GO:0045006)	3.18890426
35	anterograde synaptic vesicle transport (GO:0048490)	3.17784661
36	preassembly of GPI anchor in ER membrane (GO:0016254)	3.14818393
37	rRNA catabolic process (GO:0016075)	3.13456847
38	amino acid salvage (GO:0043102)	3.12569957
39	L-methionine salvage (GO:0071267)	3.12569957
40	L-methionine biosynthetic process (GO:0071265)	3.12569957
41	protein neddylation (GO:0045116)	3.11274347
42	inositol phosphate dephosphorylation (GO:0046855)	3.10609577
43	phosphorylated carbohydrate dephosphorylation (GO:0046838)	3.10609577
44	inositol phosphate catabolic process (GO:0071545)	3.09624260
45	proteasome assembly (GO:0043248)	3.06460377
46	cellular ketone body metabolic process (GO:0046950)	3.04872025
47	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.02083581
48	regulation of mitotic spindle checkpoint (GO:1903504)	3.02083581
49	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.01483149
50	rRNA modification (GO:0000154)	2.98960017
51	ATP biosynthetic process (GO:0006754)	2.87674910
52	prenylation (GO:0097354)	2.86999589
53	protein prenylation (GO:0018342)	2.86999589
54	protein import into peroxisome matrix (GO:0016558)	2.86860997
55	proton transport (GO:0015992)	2.86785016
56	synapsis (GO:0007129)	2.83037354
57	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.83015417
58	hydrogen ion transmembrane transport (GO:1902600)	2.82874719
59	hydrogen transport (GO:0006818)	2.82155455
60	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.80574592
61	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.79105225
62	tRNA processing (GO:0008033)	2.77988448
63	water-soluble vitamin biosynthetic process (GO:0042364)	2.77944005
64	polyol catabolic process (GO:0046174)	2.75103749
65	termination of RNA polymerase III transcription (GO:0006386)	2.74947490
66	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.74947490
67	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.74386274
68	GPI anchor biosynthetic process (GO:0006506)	2.73787652
69	axoneme assembly (GO:0035082)	2.70102548
70	ketone body metabolic process (GO:1902224)	2.69968771
71	maturation of SSU-rRNA (GO:0030490)	2.68877860
72	GPI anchor metabolic process (GO:0006505)	2.62317661
73	epithelial cilium movement (GO:0003351)	2.61410792
74	chromatin remodeling at centromere (GO:0031055)	2.59073686
75	nucleoside triphosphate biosynthetic process (GO:0009142)	2.58571527
76	regulation of feeding behavior (GO:0060259)	2.58338150
77	GTP biosynthetic process (GO:0006183)	2.58090251
78	ribosomal small subunit assembly (GO:0000028)	2.55104621
79	positive regulation of protein homodimerization activity (GO:0090073)	2.55028361
80	parental behavior (GO:0060746)	2.54805831
81	regulation of action potential (GO:0098900)	2.54685250
82	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.54185343
83	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.54185343
84	coenzyme A biosynthetic process (GO:0015937)	2.52056832
85	cullin deneddylation (GO:0010388)	2.51258585
86	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.50375165
87	pseudouridine synthesis (GO:0001522)	2.49175650
88	C-terminal protein lipidation (GO:0006501)	2.48256292
89	oxidative phosphorylation (GO:0006119)	2.47525854
90	anterograde axon cargo transport (GO:0008089)	2.47314479
91	resolution of meiotic recombination intermediates (GO:0000712)	2.47083005
92	pantothenate metabolic process (GO:0015939)	2.46564549
93	rhodopsin mediated signaling pathway (GO:0016056)	2.46411008
94	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class	2.45508159
95	mismatch repair (GO:0006298)	2.44153037
96	branched-chain amino acid catabolic process (GO:0009083)	2.42522082
97	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	2.41360102
98	myoblast migration (GO:0051451)	2.40644685
99	photoreceptor cell maintenance (GO:0045494)	2.40589214
100	aggressive behavior (GO:0002118)	2.39345335

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.31366305
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.82110105
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.77643341
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.62096804
5	VDR_22108803_ChIP-Seq_LS180_Human	3.10704311
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.93059296
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.73138155
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.62072645
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.59422888
10	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.57733652
11	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.54494223
12	VDR_23849224_ChIP-Seq_CD4+_Human	2.24534221
13	EWS_26573619_Chip-Seq_HEK293_Human	2.15927953
14	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.98926666
15	IGF1R_20145208_ChIP-Seq_DFB_Human	1.95433313
16	FOXP3_21729870_ChIP-Seq_TREG_Human	1.94421202
17	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.93953528
18	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.93342387
19	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.89647676
20	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.88133321
21	ELK1_19687146_ChIP-ChIP_HELA_Human	1.86298884
22	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.79828684
23	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.78274063
24	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.76463252
25	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.73839884
26	EZH2_22144423_ChIP-Seq_EOC_Human	1.69035091
27	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.67409987
28	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.60293633
29	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.59973455
30	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.59819359
31	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.59410523
32	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.56102610
33	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.55550656
34	FUS_26573619_Chip-Seq_HEK293_Human	1.51816926
35	TP53_22573176_ChIP-Seq_HFKS_Human	1.51207449
36	IRF1_19129219_ChIP-ChIP_H3396_Human	1.50897395
37	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.49490053
38	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.48396905
39	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.47214606
40	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.42533608
41	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.42522711
42	ER_23166858_ChIP-Seq_MCF-7_Human	1.40831329
43	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.38977767
44	MYC_18940864_ChIP-ChIP_HL60_Human	1.37610579
45	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.36601683
46	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.31718376
47	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.31564919
48	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.31564919
49	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.31246423
50	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.30133625
51	P300_19829295_ChIP-Seq_ESCs_Human	1.30037837
52	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.25126348
53	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.24813190
54	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.24240067
55	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.22054774
56	AR_20517297_ChIP-Seq_VCAP_Human	1.21442408
57	SOX2_19829295_ChIP-Seq_ESCs_Human	1.19775820
58	NANOG_19829295_ChIP-Seq_ESCs_Human	1.19775820
59	GBX2_23144817_ChIP-Seq_PC3_Human	1.17645099
60	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.15956395
61	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.13542078
62	NCOR_22424771_ChIP-Seq_293T_Human	1.13361599
63	GABP_19822575_ChIP-Seq_HepG2_Human	1.12824883
64	TAF15_26573619_Chip-Seq_HEK293_Human	1.12798554
65	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.11405419
66	CBP_20019798_ChIP-Seq_JUKART_Human	1.09574942
67	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.09574942
68	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.09187094
69	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.08068483
70	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.07528281
71	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.07407865
72	MYC_19829295_ChIP-Seq_ESCs_Human	1.06780737
73	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.05652171
74	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.05437630
75	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.05282887
76	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.04688832
77	DCP1A_22483619_ChIP-Seq_HELA_Human	1.04627304
78	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.04603807
79	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.04121207
80	HOXB7_26014856_ChIP-Seq_BT474_Human	1.03895442
81	TTF2_22483619_ChIP-Seq_HELA_Human	1.03453005
82	TCF4_22108803_ChIP-Seq_LS180_Human	1.02948641
83	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.02822286
84	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.01779848
85	ERG_20517297_ChIP-Seq_VCAP_Human	1.00165724
86	TAF2_19829295_ChIP-Seq_ESCs_Human	0.97339418
87	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.97200580
88	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.96515872
89	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.96497540
90	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.96174903
91	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.95660254
92	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.95088624
93	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.95017822
94	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.94604768
95	BCAT_22108803_ChIP-Seq_LS180_Human	0.93860881
96	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.92877910
97	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.92439722
98	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.91717838
99	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.91396700
100	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.91180619

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	4.29526067
2	MP0006292_abnormal_olfactory_placode	2.66662777
3	MP0003787_abnormal_imprinting	2.55898304
4	MP0008877_abnormal_DNA_methylation	2.50064516
5	MP0006276_abnormal_autonomic_nervous	2.44690737
6	MP0003806_abnormal_nucleotide_metabolis	2.41194042
7	MP0004147_increased_porphyrin_level	2.29414474
8	MP0009379_abnormal_foot_pigmentation	2.27533997
9	MP0004142_abnormal_muscle_tone	2.24314928
10	MP0002234_abnormal_pharynx_morphology	2.14822928
11	MP0002822_catalepsy	2.13657018
12	MP0002638_abnormal_pupillary_reflex	2.12535635
13	MP0005551_abnormal_eye_electrophysiolog	2.11512242
14	MP0004043_abnormal_pH_regulation	2.10777668
15	MP0003121_genomic_imprinting	2.08101100
16	MP0003122_maternal_imprinting	2.05509973
17	MP0005646_abnormal_pituitary_gland	2.04476873
18	MP0005367_renal/urinary_system_phenotyp	2.03358454
19	MP0000516_abnormal_urinary_system	2.03358454
20	MP0002160_abnormal_reproductive_system	2.00620158
21	MP0001984_abnormal_olfaction	1.93267112
22	MP0002102_abnormal_ear_morphology	1.78080251
23	MP0006072_abnormal_retinal_apoptosis	1.77505910
24	MP0008058_abnormal_DNA_repair	1.75493985
25	MP0003718_maternal_effect	1.71880891
26	MP0008995_early_reproductive_senescence	1.69865146
27	MP0002837_dystrophic_cardiac_calcinosis	1.68389387
28	MP0010386_abnormal_urinary_bladder	1.68290451
29	MP0004133_heterotaxia	1.64000708
30	MP0005389_reproductive_system_phenotype	1.60066211
31	MP0008875_abnormal_xenobiotic_pharmacok	1.59544787
32	MP0001529_abnormal_vocalization	1.57490360
33	MP0008872_abnormal_physiological_respon	1.56465275
34	MP0004885_abnormal_endolymph	1.50052564
35	MP0000372_irregular_coat_pigmentation	1.43586485
36	MP0003123_paternal_imprinting	1.42577706
37	MP0005084_abnormal_gallbladder_morpholo	1.38895630
38	MP0005645_abnormal_hypothalamus_physiol	1.33003979
39	MP0003880_abnormal_central_pattern	1.32581688
40	MP0009046_muscle_twitch	1.32035681
41	MP0005253_abnormal_eye_physiology	1.31710603
42	MP0006035_abnormal_mitochondrial_morpho	1.29822726
43	MP0006036_abnormal_mitochondrial_physio	1.27417846
44	MP0001919_abnormal_reproductive_system	1.26844849
45	MP0001293_anophthalmia	1.26412386
46	MP0003786_premature_aging	1.24326342
47	MP0004145_abnormal_muscle_electrophysio	1.22212831
48	MP0009764_decreased_sensitivity_to	1.21786323
49	MP0002272_abnormal_nervous_system	1.20276890
50	MP0008775_abnormal_heart_ventricle	1.19671614
51	MP0005167_abnormal_blood-brain_barrier	1.14189574
52	MP0001440_abnormal_grooming_behavior	1.14024491
53	MP0010094_abnormal_chromosome_stability	1.12999547
54	MP0005195_abnormal_posterior_eye	1.10469389
55	MP0001970_abnormal_pain_threshold	1.09136316
56	MP0002163_abnormal_gland_morphology	1.07406555
57	MP0005377_hearing/vestibular/ear_phenot	1.06067723
58	MP0003878_abnormal_ear_physiology	1.06067723
59	MP0002006_tumorigenesis	1.05564352
60	MP0001348_abnormal_lacrimal_gland	1.05315784
61	MP0001905_abnormal_dopamine_level	1.04620413
62	MP0001486_abnormal_startle_reflex	1.04598902
63	MP0002090_abnormal_vision	1.02930150
64	MP0001764_abnormal_homeostasis	0.98702841
65	MP0001986_abnormal_taste_sensitivity	0.98000895
66	MP0000631_abnormal_neuroendocrine_gland	0.97916950
67	MP0001485_abnormal_pinna_reflex	0.95797010
68	MP0004782_abnormal_surfactant_physiolog	0.95409641
69	MP0008789_abnormal_olfactory_epithelium	0.95157772
70	MP0002751_abnormal_autonomic_nervous	0.94716276
71	MP0008057_abnormal_DNA_replication	0.92835907
72	MP0002557_abnormal_social/conspecific_i	0.90544273
73	MP0005379_endocrine/exocrine_gland_phen	0.89160499
74	MP0004742_abnormal_vestibular_system	0.88849157
75	MP0005671_abnormal_response_to	0.87151878
76	MP0005636_abnormal_mineral_homeostasis	0.83292332
77	MP0002909_abnormal_adrenal_gland	0.83068696
78	MP0005499_abnormal_olfactory_system	0.82963435
79	MP0005394_taste/olfaction_phenotype	0.82963435
80	MP0002572_abnormal_emotion/affect_behav	0.81992163
81	MP0002752_abnormal_somatic_nervous	0.81802890
82	MP0003646_muscle_fatigue	0.80685052
83	MP0002733_abnormal_thermal_nociception	0.79279322
84	MP0003936_abnormal_reproductive_system	0.77979971
85	MP0000639_abnormal_adrenal_gland	0.77724252
86	MP0005395_other_phenotype	0.76867885
87	MP0002282_abnormal_trachea_morphology	0.76590006
88	MP0002735_abnormal_chemical_nociception	0.74281475
89	MP0002210_abnormal_sex_determination	0.74043971
90	MP0009745_abnormal_behavioral_response	0.73153996
91	MP0005332_abnormal_amino_acid	0.73121648
92	MP0001968_abnormal_touch/_nociception	0.72913581
93	MP0002928_abnormal_bile_duct	0.72229490
94	MP0003879_abnormal_hair_cell	0.70375670
95	MP0003075_altered_response_to	0.69773728
96	MP0001145_abnormal_male_reproductive	0.69659583
97	MP0004134_abnormal_chest_morphology	0.68055978
98	MP0000653_abnormal_sex_gland	0.67470335
99	MP0003283_abnormal_digestive_organ	0.65529645
100	MP0001756_abnormal_urination	0.65209841

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.80592720
2	Progressive macrocephaly (HP:0004481)	4.38422373
3	Abnormal mitochondria in muscle tissue (HP:0008316)	4.34751895
4	Mitochondrial inheritance (HP:0001427)	4.31110400
5	Decreased central vision (HP:0007663)	4.22763263
6	Acute encephalopathy (HP:0006846)	4.22163282
7	Increased CSF lactate (HP:0002490)	4.07713958
8	Hepatocellular necrosis (HP:0001404)	3.90989558
9	Lipid accumulation in hepatocytes (HP:0006561)	3.83085681
10	Increased hepatocellular lipid droplets (HP:0006565)	3.76458449
11	Congenital, generalized hypertrichosis (HP:0004540)	3.65754696
12	Hepatic necrosis (HP:0002605)	3.61784965
13	Type II lissencephaly (HP:0007260)	3.59136882
14	Hypothermia (HP:0002045)	3.51005283
15	3-Methylglutaconic aciduria (HP:0003535)	3.35712921
16	Abnormality of the labia minora (HP:0012880)	3.23447845
17	Cerebral edema (HP:0002181)	3.00149720
18	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.97507541
19	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.97507541
20	Increased intramyocellular lipid droplets (HP:0012240)	2.92511608
21	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.90511070
22	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.81932941
23	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.81204826
24	Pancreatic fibrosis (HP:0100732)	2.76733837
25	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.76305589
26	Congenital stationary night blindness (HP:0007642)	2.73546814
27	Polydipsia (HP:0001959)	2.71802306
28	Abnormal drinking behavior (HP:0030082)	2.71802306
29	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.70643249
30	Hypomagnesemia (HP:0002917)	2.67338530
31	Methylmalonic aciduria (HP:0012120)	2.64051970
32	Cerebellar dysplasia (HP:0007033)	2.63569003
33	Increased serum lactate (HP:0002151)	2.60161090
34	Focal motor seizures (HP:0011153)	2.59489775
35	Increased muscle lipid content (HP:0009058)	2.59091395
36	Methylmalonic acidemia (HP:0002912)	2.58578703
37	Abnormal rod and cone electroretinograms (HP:0008323)	2.50939069
38	Optic disc pallor (HP:0000543)	2.43901427
39	Renal Fanconi syndrome (HP:0001994)	2.43718369
40	Microvesicular hepatic steatosis (HP:0001414)	2.42776201
41	Lactic acidosis (HP:0003128)	2.42258531
42	Type 2 muscle fiber atrophy (HP:0003554)	2.38292840
43	Nephronophthisis (HP:0000090)	2.37903241
44	Exertional dyspnea (HP:0002875)	2.37209532
45	Respiratory failure (HP:0002878)	2.36142181
46	Dry hair (HP:0011359)	2.35983815
47	Elevated erythrocyte sedimentation rate (HP:0003565)	2.31711810
48	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.31707662
49	Absent/shortened dynein arms (HP:0200106)	2.31707662
50	CNS demyelination (HP:0007305)	2.30305511
51	Keratoconus (HP:0000563)	2.29121192
52	Increased corneal curvature (HP:0100692)	2.29121192
53	Molar tooth sign on MRI (HP:0002419)	2.28692391
54	Abnormality of midbrain morphology (HP:0002418)	2.28692391
55	Exercise intolerance (HP:0003546)	2.28482869
56	Pancreatic cysts (HP:0001737)	2.28309421
57	Tetany (HP:0001281)	2.28000643
58	Lethargy (HP:0001254)	2.27721566
59	Supernumerary spleens (HP:0009799)	2.27459093
60	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.26651208
61	Attenuation of retinal blood vessels (HP:0007843)	2.26611367
62	Medial flaring of the eyebrow (HP:0010747)	2.25547162
63	Failure to thrive in infancy (HP:0001531)	2.25432534
64	Visual hallucinations (HP:0002367)	2.23424172
65	True hermaphroditism (HP:0010459)	2.23105167
66	Abnormality of magnesium homeostasis (HP:0004921)	2.15427520
67	Hypochromic microcytic anemia (HP:0004840)	2.15345779
68	Leukodystrophy (HP:0002415)	2.14120672
69	Type I transferrin isoform profile (HP:0003642)	2.10561909
70	Muscle fiber atrophy (HP:0100295)	2.09149962
71	Glycosuria (HP:0003076)	2.06956888
72	Abnormality of urine glucose concentration (HP:0011016)	2.06956888
73	Neoplasm of the adrenal cortex (HP:0100641)	2.06222696
74	Polyuria (HP:0000103)	2.03327784
75	Abnormal number of erythroid precursors (HP:0012131)	2.03061268
76	Hyperglycinuria (HP:0003108)	2.01449376
77	Increased circulating renin level (HP:0000848)	1.99977719
78	Abnormality of cells of the erythroid lineage (HP:0012130)	1.95221740
79	Colon cancer (HP:0003003)	1.93830732
80	Hyperphosphaturia (HP:0003109)	1.93156908
81	Brushfield spots (HP:0001088)	1.91209467
82	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.90655402
83	Hyperthyroidism (HP:0000836)	1.90489165
84	Abnormality of the pons (HP:0007361)	1.89569385
85	Hyperglycinemia (HP:0002154)	1.87488932
86	Dicarboxylic aciduria (HP:0003215)	1.85643824
87	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.85643824
88	Tachypnea (HP:0002789)	1.83887223
89	Constricted visual fields (HP:0001133)	1.83490087
90	Abnormal respiratory epithelium morphology (HP:0012253)	1.79860535
91	Abnormal respiratory motile cilium morphology (HP:0005938)	1.79860535
92	Lissencephaly (HP:0001339)	1.79175177
93	Abnormality of the renal medulla (HP:0100957)	1.76196257
94	Abnormality of the renal cortex (HP:0011035)	1.75031640
95	Palpitations (HP:0001962)	1.73887722
96	Renal cortical cysts (HP:0000803)	1.70680687
97	Sclerocornea (HP:0000647)	1.70551044
98	Abnormality of secondary sexual hair (HP:0009888)	1.70545827
99	Abnormality of the axillary hair (HP:0100134)	1.70545827
100	Hypoplasia of the pons (HP:0012110)	1.70471070

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK16	4.72999514
2	FRK	4.01204102
3	TAOK3	3.37819430
4	EIF2AK1	3.21469296
5	ZAK	3.08519233
6	VRK2	2.81187460
7	MAPKAPK5	2.49479132
8	EIF2AK3	2.33255137
9	BMPR1B	2.18142093
10	NUAK1	2.13005513
11	MKNK1	1.97256540
12	ADRBK2	1.84992453
13	GRK1	1.84607958
14	MAP4K2	1.74827630
15	PIM2	1.69634178
16	PLK3	1.67955702
17	MAP2K7	1.63123157
18	PLK2	1.56573833
19	TRIM28	1.54049557
20	TRPM7	1.51514919
21	VRK1	1.50038162
22	TIE1	1.49068695
23	MST4	1.46509461
24	BMPR2	1.43711984
25	PAK3	1.43218941
26	PHKG2	1.40071866
27	PHKG1	1.40071866
28	NME2	1.37452827
29	TSSK6	1.31721253
30	PDK2	1.30378532
31	WNK4	1.23778913
32	ERBB3	1.20466848
33	MAPK13	1.17445668
34	STK3	1.15413612
35	DYRK2	1.12311732
36	TLK1	1.07859421
37	CDC7	1.07470110
38	BCR	1.07128752
39	STK24	1.02490212
40	MAPKAPK3	1.02280610
41	STK38L	1.01311543
42	PINK1	0.98601004
43	CAMKK2	0.93108300
44	FGFR2	0.92132974
45	TEC	0.91094794
46	OXSR1	0.89365545
47	MAP3K4	0.89169812
48	STK4	0.89095333
49	BCKDK	0.86230848
50	DAPK3	0.85760137
51	MAP3K12	0.84132516
52	CDK8	0.83575290
53	RPS6KB2	0.82865057
54	ALK	0.78004845
55	WNK3	0.76065014
56	TAF1	0.74271080
57	DAPK2	0.69999955
58	FES	0.67811627
59	PRKCG	0.66822827
60	RPS6KA5	0.65494657
61	CSNK1G3	0.64732038
62	CSNK1G2	0.63864000
63	INSRR	0.63052451
64	PLK1	0.62105101
65	SRPK1	0.60568112
66	ATR	0.60416613
67	MAP3K11	0.60119720
68	CAMK2D	0.59915834
69	PLK4	0.59406827
70	CSNK1A1L	0.58550861
71	TNIK	0.57384157
72	EIF2AK2	0.55068763
73	IKBKB	0.53881193
74	TNK2	0.52580606
75	NEK2	0.51120276
76	CSNK1G1	0.50179465
77	CSNK2A2	0.49435785
78	CSNK2A1	0.49294687
79	MAP2K6	0.48931178
80	AURKB	0.48188596
81	MINK1	0.46624438
82	ABL2	0.44495478
83	CAMK2A	0.44282335
84	ADRBK1	0.43747326
85	CSNK1E	0.43695868
86	ABL1	0.42675882
87	PRKCE	0.41917702
88	NEK1	0.41276955
89	CSNK1A1	0.41226964
90	PRKAA2	0.40748336
91	PRKCI	0.39954642
92	PRKACA	0.37386698
93	DYRK1B	0.36942968
94	OBSCN	0.36941301
95	NTRK3	0.36745237
96	STK11	0.35922729
97	DAPK1	0.35771910
98	PRKACB	0.34526859
99	PRKCA	0.33190753
100	CAMKK1	0.32448913

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.98904443
2	Parkinsons disease_Homo sapiens_hsa05012	3.17043750
3	Asthma_Homo sapiens_hsa05310	2.73857142
4	Protein export_Homo sapiens_hsa03060	2.64964528
5	Ribosome_Homo sapiens_hsa03010	2.59955657
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.57090139
7	Proteasome_Homo sapiens_hsa03050	2.51391954
8	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.29778629
9	Phototransduction_Homo sapiens_hsa04744	2.26811958
10	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.24328992
11	Huntingtons disease_Homo sapiens_hsa05016	2.22268707
12	Homologous recombination_Homo sapiens_hsa03440	2.08267994
13	Alzheimers disease_Homo sapiens_hsa05010	2.07513534
14	One carbon pool by folate_Homo sapiens_hsa00670	2.06846875
15	Cardiac muscle contraction_Homo sapiens_hsa04260	1.89702730
16	RNA polymerase_Homo sapiens_hsa03020	1.88997716
17	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.87049010
18	RNA degradation_Homo sapiens_hsa03018	1.87038013
19	Propanoate metabolism_Homo sapiens_hsa00640	1.75557255
20	Type I diabetes mellitus_Homo sapiens_hsa04940	1.75055249
21	Linoleic acid metabolism_Homo sapiens_hsa00591	1.69694101
22	Fanconi anemia pathway_Homo sapiens_hsa03460	1.66336926
23	Allograft rejection_Homo sapiens_hsa05330	1.57525063
24	Non-homologous end-joining_Homo sapiens_hsa03450	1.56982114
25	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.54902300
26	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.53480987
27	Basal transcription factors_Homo sapiens_hsa03022	1.52710444
28	Graft-versus-host disease_Homo sapiens_hsa05332	1.50074340
29	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.49467339
30	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.44598111
31	Mismatch repair_Homo sapiens_hsa03430	1.44496761
32	Nucleotide excision repair_Homo sapiens_hsa03420	1.40202395
33	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.39004938
34	Peroxisome_Homo sapiens_hsa04146	1.35610726
35	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.32819938
36	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.29333488
37	Collecting duct acid secretion_Homo sapiens_hsa04966	1.28557139
38	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.25440703
39	Caffeine metabolism_Homo sapiens_hsa00232	1.24067363
40	Regulation of autophagy_Homo sapiens_hsa04140	1.21918257
41	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.17984208
42	DNA replication_Homo sapiens_hsa03030	1.15661360
43	Purine metabolism_Homo sapiens_hsa00230	1.15427078
44	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.06797046
45	Butanoate metabolism_Homo sapiens_hsa00650	1.06132881
46	Rheumatoid arthritis_Homo sapiens_hsa05323	1.03404037
47	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.96763124
48	Spliceosome_Homo sapiens_hsa03040	0.95940178
49	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.90258351
50	Ether lipid metabolism_Homo sapiens_hsa00565	0.89965261
51	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.89893696
52	Pyrimidine metabolism_Homo sapiens_hsa00240	0.89191891
53	Retinol metabolism_Homo sapiens_hsa00830	0.86490016
54	RNA transport_Homo sapiens_hsa03013	0.85261724
55	Olfactory transduction_Homo sapiens_hsa04740	0.83701667
56	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.79094107
57	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.76778301
58	Tryptophan metabolism_Homo sapiens_hsa00380	0.72823805
59	Metabolic pathways_Homo sapiens_hsa01100	0.71499138
60	Nitrogen metabolism_Homo sapiens_hsa00910	0.70922456
61	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.70240841
62	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.70168757
63	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.65311549
64	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.63219506
65	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.63068946
66	Sulfur relay system_Homo sapiens_hsa04122	0.62717818
67	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.60675600
68	Chemical carcinogenesis_Homo sapiens_hsa05204	0.58779596
69	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.58576643
70	Insulin secretion_Homo sapiens_hsa04911	0.57371799
71	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.56863115
72	Nicotine addiction_Homo sapiens_hsa05033	0.52225095
73	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.52188534
74	ABC transporters_Homo sapiens_hsa02010	0.50410145
75	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.49963148
76	Selenocompound metabolism_Homo sapiens_hsa00450	0.46233004
77	Antigen processing and presentation_Homo sapiens_hsa04612	0.45527432
78	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.45362186
79	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.43407682
80	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.43088746
81	Pyruvate metabolism_Homo sapiens_hsa00620	0.42652193
82	Circadian entrainment_Homo sapiens_hsa04713	0.40790250
83	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.40681763
84	Sulfur metabolism_Homo sapiens_hsa00920	0.38547246
85	Base excision repair_Homo sapiens_hsa03410	0.37548086
86	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.36437423
87	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.34573323
88	p53 signaling pathway_Homo sapiens_hsa04115	0.31488930
89	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.31122076
90	Taste transduction_Homo sapiens_hsa04742	0.29750539
91	Salivary secretion_Homo sapiens_hsa04970	0.29379090
92	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.28926890
93	Glutathione metabolism_Homo sapiens_hsa00480	0.28691817
94	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.27776940
95	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.27003213
96	Mineral absorption_Homo sapiens_hsa04978	0.26640970
97	Fatty acid degradation_Homo sapiens_hsa00071	0.26605960
98	Folate biosynthesis_Homo sapiens_hsa00790	0.24659603
99	Viral myocarditis_Homo sapiens_hsa05416	0.22470574
100	Morphine addiction_Homo sapiens_hsa05032	0.20911489

SNRPEP3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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