ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein neddylation (GO:0045116)	6.04282874
2	viral transcription (GO:0019083)	5.25401174
3	regulation of cilium movement (GO:0003352)	5.22339427
4	ribosomal small subunit assembly (GO:0000028)	5.20317860
5	maturation of SSU-rRNA (GO:0030490)	5.14925728
6	translational termination (GO:0006415)	5.11236061
7	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.06392971
8	ATP synthesis coupled proton transport (GO:0015986)	5.06392971
9	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.72805700
10	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.57430054
11	behavioral response to nicotine (GO:0035095)	4.56902654
12	translational elongation (GO:0006414)	4.55975881
13	cotranslational protein targeting to membrane (GO:0006613)	4.49116797
14	protein targeting to ER (GO:0045047)	4.48722249
15	DNA deamination (GO:0045006)	4.46355082
16	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.32361232
17	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.31516183
18	base-excision repair, AP site formation (GO:0006285)	4.27945485
19	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.26649509
20	protein localization to endoplasmic reticulum (GO:0070972)	4.25618326
21	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.25286598
22	ribosomal small subunit biogenesis (GO:0042274)	4.18269865
23	protein complex biogenesis (GO:0070271)	4.07678469
24	chaperone-mediated protein transport (GO:0072321)	4.06982749
25	respiratory electron transport chain (GO:0022904)	4.05395735
26	electron transport chain (GO:0022900)	3.99921264
27	cellular protein complex disassembly (GO:0043624)	3.95585506
28	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.94128472
29	NADH dehydrogenase complex assembly (GO:0010257)	3.94128472
30	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.94128472
31	viral life cycle (GO:0019058)	3.89822062
32	regulation of microtubule-based movement (GO:0060632)	3.86445199
33	negative regulation by host of viral transcription (GO:0043922)	3.83248866
34	ubiquinone biosynthetic process (GO:0006744)	3.83119539
35	mitochondrial respiratory chain complex assembly (GO:0033108)	3.79764644
36	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.73068845
37	translational initiation (GO:0006413)	3.66738737
38	water-soluble vitamin biosynthetic process (GO:0042364)	3.56331183
39	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.53901983
40	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.53901983
41	cytidine deamination (GO:0009972)	3.50067847
42	cytidine metabolic process (GO:0046087)	3.50067847
43	cytidine catabolic process (GO:0006216)	3.50067847
44	translation (GO:0006412)	3.47273206
45	ribosomal large subunit biogenesis (GO:0042273)	3.41946921
46	ubiquinone metabolic process (GO:0006743)	3.39541277
47	mannosylation (GO:0097502)	3.34558421
48	GTP biosynthetic process (GO:0006183)	3.28922745
49	protein-cofactor linkage (GO:0018065)	3.28782644
50	glyoxylate metabolic process (GO:0046487)	3.25544397
51	protein complex disassembly (GO:0043241)	3.24490507
52	quinone biosynthetic process (GO:1901663)	3.15932395
53	purine deoxyribonucleotide catabolic process (GO:0009155)	3.13822985
54	macromolecular complex disassembly (GO:0032984)	3.07784332
55	DNA double-strand break processing (GO:0000729)	3.06942263
56	rRNA processing (GO:0006364)	3.03531925
57	platelet dense granule organization (GO:0060155)	3.00614096
58	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.96788675
59	rRNA metabolic process (GO:0016072)	2.95986549
60	protein polyglutamylation (GO:0018095)	2.95833900
61	nonmotile primary cilium assembly (GO:0035058)	2.94625814
62	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.91444766
63	respiratory chain complex IV assembly (GO:0008535)	2.88225539
64	UTP biosynthetic process (GO:0006228)	2.86898635
65	glycerol metabolic process (GO:0006071)	2.85788487
66	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.85297552
67	attachment of spindle microtubules to kinetochore (GO:0008608)	2.85206711
68	negative regulation of T cell differentiation in thymus (GO:0033085)	2.85109403
69	UTP metabolic process (GO:0046051)	2.84505569
70	mRNA catabolic process (GO:0006402)	2.82544302
71	protein targeting to membrane (GO:0006612)	2.82490652
72	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.82389558
73	cellular component biogenesis (GO:0044085)	2.81585483
74	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.80115048
75	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.78969446
76	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.78969446
77	cell proliferation in forebrain (GO:0021846)	2.78793692
78	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.78640985
79	otic vesicle formation (GO:0030916)	2.78608708
80	cytochrome complex assembly (GO:0017004)	2.74461025
81	negative regulation of telomere maintenance (GO:0032205)	2.74369066
82	tRNA processing (GO:0008033)	2.74219650
83	ATP biosynthetic process (GO:0006754)	2.71521175
84	proteasome assembly (GO:0043248)	2.71488360
85	pseudouridine synthesis (GO:0001522)	2.70489139
86	ncRNA 3-end processing (GO:0043628)	2.70439614
87	aldehyde catabolic process (GO:0046185)	2.69961610
88	piRNA metabolic process (GO:0034587)	2.69750487
89	DNA catabolic process, exonucleolytic (GO:0000738)	2.68284704
90	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.67295611
91	pattern specification involved in kidney development (GO:0061004)	2.63980307
92	deoxyribonucleotide catabolic process (GO:0009264)	2.62791822
93	chromatin remodeling at centromere (GO:0031055)	2.62743121
94	RNA catabolic process (GO:0006401)	2.62528065
95	ribonucleoprotein complex biogenesis (GO:0022613)	2.58332109
96	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.58079673
97	termination of RNA polymerase III transcription (GO:0006386)	2.58079673
98	intracellular protein transmembrane import (GO:0044743)	2.54914467
99	neural tube formation (GO:0001841)	2.53923451
100	alditol metabolic process (GO:0019400)	2.53618510

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.90304746
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.43469130
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.32243848
4	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.29670217
5	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.05845695
6	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.02406207
7	EZH2_22144423_ChIP-Seq_EOC_Human	2.89756537
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.85493220
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.78513271
10	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.63735796
11	VDR_23849224_ChIP-Seq_CD4+_Human	2.50765241
12	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.48894603
13	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.38317542
14	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.28732587
15	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.23315234
16	E2F7_22180533_ChIP-Seq_HELA_Human	2.17222584
17	ELK1_19687146_ChIP-ChIP_HELA_Human	2.15570968
18	FOXP3_21729870_ChIP-Seq_TREG_Human	2.13731390
19	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.07220125
20	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.07058209
21	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.05113378
22	IGF1R_20145208_ChIP-Seq_DFB_Human	1.94737472
23	MYC_18940864_ChIP-ChIP_HL60_Human	1.84894146
24	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.83717309
25	FUS_26573619_Chip-Seq_HEK293_Human	1.76214267
26	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.75506474
27	EWS_26573619_Chip-Seq_HEK293_Human	1.72094997
28	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.65746195
29	VDR_22108803_ChIP-Seq_LS180_Human	1.64517340
30	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.62992443
31	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.61799863
32	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.57863115
33	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.55335227
34	TP53_22573176_ChIP-Seq_HFKS_Human	1.51509497
35	TTF2_22483619_ChIP-Seq_HELA_Human	1.49920337
36	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.47924720
37	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.45645384
38	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.45373294
39	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.41761128
40	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.39957428
41	GABP_19822575_ChIP-Seq_HepG2_Human	1.35345621
42	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.33231814
43	XRN2_22483619_ChIP-Seq_HELA_Human	1.32759432
44	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.32212883
45	DCP1A_22483619_ChIP-Seq_HELA_Human	1.30889658
46	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.30001643
47	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.27482295
48	GBX2_23144817_ChIP-Seq_PC3_Human	1.25002227
49	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.24172500
50	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.24064861
51	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.24064861
52	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.23805076
53	ER_23166858_ChIP-Seq_MCF-7_Human	1.22450724
54	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.18964764
55	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.18451071
56	AR_20517297_ChIP-Seq_VCAP_Human	1.16941663
57	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.16249628
58	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.14878096
59	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.14786760
60	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.13969271
61	HTT_18923047_ChIP-ChIP_STHdh_Human	1.11074184
62	NANOG_20526341_ChIP-Seq_ESCs_Human	1.10690120
63	CIITA_25753668_ChIP-Seq_RAJI_Human	1.09910912
64	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.09057880
65	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.08062342
66	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.07577811
67	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.04487116
68	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.03871254
69	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.03629912
70	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.03190026
71	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.03026967
72	NCOR_22424771_ChIP-Seq_293T_Human	1.02203221
73	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.01573263
74	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.01046948
75	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.00800374
76	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.00474698
77	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.99612171
78	RNF2_27304074_Chip-Seq_NSC_Mouse	0.99244543
79	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.98518878
80	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.97329837
81	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.96461575
82	IRF1_19129219_ChIP-ChIP_H3396_Human	0.96072740
83	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.95444213
84	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.95341113
85	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.94409889
86	TAF2_19829295_ChIP-Seq_ESCs_Human	0.94099675
87	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.93459206
88	KDM5A_27292631_Chip-Seq_BREAST_Human	0.93120149
89	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.93083731
90	RBPJ_21746931_ChIP-Seq_IB4_Human	0.91546468
91	P300_19829295_ChIP-Seq_ESCs_Human	0.91194114
92	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.91040873
93	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.90969008
94	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.90759449
95	PHF8_20622853_ChIP-Seq_HELA_Human	0.90541564
96	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.90264516
97	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.90050573
98	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.89696730
99	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.89406751
100	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.88989376

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003787_abnormal_imprinting	3.85235604
2	MP0002163_abnormal_gland_morphology	2.89036049
3	MP0003646_muscle_fatigue	2.79804639
4	MP0006292_abnormal_olfactory_placode	2.73430881
5	MP0009379_abnormal_foot_pigmentation	2.64443700
6	MP0008058_abnormal_DNA_repair	2.59622493
7	MP0003011_delayed_dark_adaptation	2.56249092
8	MP0008877_abnormal_DNA_methylation	2.53074178
9	MP0003183_abnormal_peptide_metabolism	2.43047448
10	MP0002736_abnormal_nociception_after	2.27216713
11	MP0001968_abnormal_touch/_nociception	2.17634859
12	MP0010386_abnormal_urinary_bladder	2.08368396
13	MP0006072_abnormal_retinal_apoptosis	2.07643990
14	MP0003186_abnormal_redox_activity	2.02940715
15	MP0004147_increased_porphyrin_level	1.98788799
16	MP0008872_abnormal_physiological_respon	1.98748249
17	MP0002102_abnormal_ear_morphology	1.95623832
18	MP0001919_abnormal_reproductive_system	1.94995912
19	MP0004885_abnormal_endolymph	1.93335681
20	MP0002876_abnormal_thyroid_physiology	1.87256617
21	MP0002638_abnormal_pupillary_reflex	1.85308298
22	MP0005084_abnormal_gallbladder_morpholo	1.81562837
23	MP0005389_reproductive_system_phenotype	1.77022684
24	MP0002160_abnormal_reproductive_system	1.76281895
25	MP0005646_abnormal_pituitary_gland	1.74520255
26	MP0005670_abnormal_white_adipose	1.67630366
27	MP0003880_abnormal_central_pattern	1.65450182
28	MP0005379_endocrine/exocrine_gland_phen	1.63769357
29	MP0005671_abnormal_response_to	1.61981236
30	MP0005551_abnormal_eye_electrophysiolog	1.59374922
31	MP0002653_abnormal_ependyma_morphology	1.57009421
32	MP0001485_abnormal_pinna_reflex	1.53583092
33	MP0008789_abnormal_olfactory_epithelium	1.47420002
34	MP0005253_abnormal_eye_physiology	1.42667157
35	MP0002837_dystrophic_cardiac_calcinosis	1.40309596
36	MP0003121_genomic_imprinting	1.40178318
37	MP0001440_abnormal_grooming_behavior	1.38106570
38	MP0005645_abnormal_hypothalamus_physiol	1.36453238
39	MP0005174_abnormal_tail_pigmentation	1.35742698
40	MP0000372_irregular_coat_pigmentation	1.35015299
41	MP0001905_abnormal_dopamine_level	1.33079174
42	MP0008875_abnormal_xenobiotic_pharmacok	1.31764124
43	MP0002928_abnormal_bile_duct	1.28995215
44	MP0002095_abnormal_skin_pigmentation	1.26930555
45	MP0010094_abnormal_chromosome_stability	1.25748462
46	MP0005377_hearing/vestibular/ear_phenot	1.25203190
47	MP0003878_abnormal_ear_physiology	1.25203190
48	MP0006036_abnormal_mitochondrial_physio	1.22838700
49	MP0000631_abnormal_neuroendocrine_gland	1.21830734
50	MP0004742_abnormal_vestibular_system	1.20373978
51	MP0006276_abnormal_autonomic_nervous	1.18185947
52	MP0006035_abnormal_mitochondrial_morpho	1.12861661
53	MP0003195_calcinosis	1.11406447
54	MP0002272_abnormal_nervous_system	1.11142652
55	MP0003693_abnormal_embryo_hatching	1.10628039
56	MP0000049_abnormal_middle_ear	1.10447341
57	MP0004142_abnormal_muscle_tone	1.10352993
58	MP0003718_maternal_effect	1.09362885
59	MP0003567_abnormal_fetal_cardiomyocyte	1.07600546
60	MP0003937_abnormal_limbs/digits/tail_de	1.06708204
61	MP0003786_premature_aging	1.02321230
62	MP0002210_abnormal_sex_determination	1.01634127
63	MP0004043_abnormal_pH_regulation	1.01335304
64	MP0008932_abnormal_embryonic_tissue	1.00416493
65	MP0001188_hyperpigmentation	0.99613174
66	MP0004133_heterotaxia	0.98719836
67	MP0002234_abnormal_pharynx_morphology	0.97931700
68	MP0004957_abnormal_blastocyst_morpholog	0.96758714
69	MP0001529_abnormal_vocalization	0.96445025
70	MP0002938_white_spotting	0.95941474
71	MP0002557_abnormal_social/conspecific_i	0.92764366
72	MP0005195_abnormal_posterior_eye	0.91845044
73	MP0004145_abnormal_muscle_electrophysio	0.91475988
74	MP0000427_abnormal_hair_cycle	0.91172797
75	MP0005636_abnormal_mineral_homeostasis	0.90534664
76	MP0001970_abnormal_pain_threshold	0.86337564
77	MP0005499_abnormal_olfactory_system	0.84701810
78	MP0005394_taste/olfaction_phenotype	0.84701810
79	MP0009745_abnormal_behavioral_response	0.84691568
80	MP0009046_muscle_twitch	0.84531905
81	MP0005647_abnormal_sex_gland	0.84030746
82	MP0001486_abnormal_startle_reflex	0.82089771
83	MP0002282_abnormal_trachea_morphology	0.81779646
84	MP0001764_abnormal_homeostasis	0.80170796
85	MP0001293_anophthalmia	0.79384423
86	MP0001929_abnormal_gametogenesis	0.79086835
87	MP0002067_abnormal_sensory_capabilities	0.78706135
88	MP0001119_abnormal_female_reproductive	0.78511350
89	MP0005075_abnormal_melanosome_morpholog	0.77885146
90	MP0003123_paternal_imprinting	0.77250832
91	MP0003136_yellow_coat_color	0.76919334
92	MP0002752_abnormal_somatic_nervous	0.76286892
93	MP0000653_abnormal_sex_gland	0.75681976
94	MP0008007_abnormal_cellular_replicative	0.73818806
95	MP0005171_absent_coat_pigmentation	0.72579272
96	MP0001145_abnormal_male_reproductive	0.72528299
97	MP0000538_abnormal_urinary_bladder	0.71669828
98	MP0002693_abnormal_pancreas_physiology	0.70278930
99	MP0001984_abnormal_olfaction	0.68128047
100	MP0003111_abnormal_nucleus_morphology	0.66914337

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Renal cortical cysts (HP:0000803)	4.47894017
2	Acute necrotizing encephalopathy (HP:0006965)	4.24133124
3	Abnormal mitochondria in muscle tissue (HP:0008316)	3.86982369
4	Reticulocytopenia (HP:0001896)	3.76259209
5	Acute encephalopathy (HP:0006846)	3.66572905
6	Type II lissencephaly (HP:0007260)	3.52183310
7	Pancreatic cysts (HP:0001737)	3.47353995
8	Mitochondrial inheritance (HP:0001427)	3.46793852
9	Volvulus (HP:0002580)	3.46788641
10	Congenital stationary night blindness (HP:0007642)	3.38338041
11	Progressive macrocephaly (HP:0004481)	3.35129152
12	Molar tooth sign on MRI (HP:0002419)	3.17706558
13	Abnormality of midbrain morphology (HP:0002418)	3.17706558
14	Methylmalonic aciduria (HP:0012120)	3.14000176
15	Increased CSF lactate (HP:0002490)	3.11133207
16	Pancreatic fibrosis (HP:0100732)	3.09110133
17	Aplastic anemia (HP:0001915)	3.04671188
18	Methylmalonic acidemia (HP:0002912)	3.04412521
19	Abnormality of the renal cortex (HP:0011035)	3.03784596
20	Colon cancer (HP:0003003)	2.92273194
21	3-Methylglutaconic aciduria (HP:0003535)	2.91860167
22	Abnormality of cells of the erythroid lineage (HP:0012130)	2.86872978
23	Absent thumb (HP:0009777)	2.85119136
24	True hermaphroditism (HP:0010459)	2.79373480
25	Cerebral edema (HP:0002181)	2.73707032
26	Pancytopenia (HP:0001876)	2.68636774
27	Medial flaring of the eyebrow (HP:0010747)	2.67571450
28	Horseshoe kidney (HP:0000085)	2.66455307
29	Abnormal number of erythroid precursors (HP:0012131)	2.60358026
30	Hepatocellular necrosis (HP:0001404)	2.59419088
31	Lactic acidosis (HP:0003128)	2.46466204
32	Cerebellar dysplasia (HP:0007033)	2.46294949
33	Hepatic necrosis (HP:0002605)	2.41110717
34	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.40076095
35	Asplenia (HP:0001746)	2.37893977
36	Macrocytic anemia (HP:0001972)	2.35739588
37	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.35144385
38	Hypoplasia of the radius (HP:0002984)	2.31780791
39	Abnormality of the ileum (HP:0001549)	2.28049485
40	Optic disc pallor (HP:0000543)	2.27259768
41	Oligodactyly (hands) (HP:0001180)	2.26921705
42	Oligodactyly (HP:0012165)	2.24369847
43	Meckel diverticulum (HP:0002245)	2.20739571
44	Ectopic kidney (HP:0000086)	2.18657596
45	Congenital primary aphakia (HP:0007707)	2.18376806
46	Gait imbalance (HP:0002141)	2.17181889
47	Increased hepatocellular lipid droplets (HP:0006565)	2.13739132
48	Anencephaly (HP:0002323)	2.13301235
49	Postaxial foot polydactyly (HP:0001830)	2.12748845
50	Increased serum lactate (HP:0002151)	2.12742678
51	Dicarboxylic aciduria (HP:0003215)	2.12660368
52	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.12660368
53	IgG deficiency (HP:0004315)	2.12304199
54	Severe combined immunodeficiency (HP:0004430)	2.11736862
55	Anterior segment dysgenesis (HP:0007700)	2.10192106
56	Forearm undergrowth (HP:0009821)	2.09339328
57	Constricted visual fields (HP:0001133)	2.08574212
58	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.07861564
59	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.07861564
60	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.03208014
61	Nephronophthisis (HP:0000090)	2.03033348
62	Abnormality of alanine metabolism (HP:0010916)	2.02648975
63	Hyperalaninemia (HP:0003348)	2.02648975
64	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.02648975
65	Respiratory failure (HP:0002878)	2.02402041
66	Hyperglycinemia (HP:0002154)	2.02369806
67	Lipid accumulation in hepatocytes (HP:0006561)	2.02155200
68	Abnormality of B cell number (HP:0010975)	2.01742452
69	Stomatitis (HP:0010280)	2.00984817
70	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.99080518
71	Nephrogenic diabetes insipidus (HP:0009806)	1.98643822
72	Aplasia/hypoplasia of the uterus (HP:0008684)	1.98150985
73	Pallor (HP:0000980)	1.97289853
74	Leukodystrophy (HP:0002415)	1.96332352
75	Triphalangeal thumb (HP:0001199)	1.94502192
76	Abnormality of the preputium (HP:0100587)	1.93277669
77	Carpal bone hypoplasia (HP:0001498)	1.92726907
78	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.91687042
79	Cystic liver disease (HP:0006706)	1.87335376
80	Increased intramyocellular lipid droplets (HP:0012240)	1.87175842
81	Lethargy (HP:0001254)	1.86216731
82	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.84821419
83	Abnormality of the renal medulla (HP:0100957)	1.84137073
84	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.82881978
85	Exercise intolerance (HP:0003546)	1.81303910
86	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.80799071
87	Short tibia (HP:0005736)	1.80551290
88	Short thumb (HP:0009778)	1.80347956
89	Cerebral hypomyelination (HP:0006808)	1.79169970
90	Hypoplasia of the pons (HP:0012110)	1.76855479
91	Lissencephaly (HP:0001339)	1.75529204
92	Stomach cancer (HP:0012126)	1.73890749
93	Chromsome breakage (HP:0040012)	1.73266575
94	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.72485376
95	Congenital, generalized hypertrichosis (HP:0004540)	1.71495541
96	Renal Fanconi syndrome (HP:0001994)	1.69905898
97	Abnormality of the renal collecting system (HP:0004742)	1.69119169
98	Oral leukoplakia (HP:0002745)	1.67947477
99	Abnormality of the pons (HP:0007361)	1.65576079
100	Combined immunodeficiency (HP:0005387)	1.64961369

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NEK1	7.12374963
2	TXK	3.26859513
3	ADRBK2	2.45543163
4	PLK4	2.26716364
5	NUAK1	2.23878195
6	WNK4	2.08750141
7	BCKDK	2.08147794
8	NEK2	2.07010674
9	VRK2	2.05783253
10	KDR	1.98891510
11	PINK1	1.96152126
12	STK16	1.86926701
13	CAMKK2	1.79797410
14	TAOK3	1.79015228
15	BUB1	1.72662754
16	BMPR1B	1.65640500
17	PASK	1.60556384
18	ZAK	1.57924558
19	MAP4K2	1.56855533
20	GRK1	1.54649896
21	STK39	1.45419969
22	TSSK6	1.42669686
23	TAF1	1.37098686
24	MAPKAPK5	1.36807713
25	CDC7	1.35687843
26	PNCK	1.23020366
27	PDK2	1.18964026
28	CAMKK1	1.16384563
29	PLK2	1.12723225
30	DYRK2	1.12111240
31	MAP3K12	1.08116477
32	MAPKAPK3	1.06703718
33	SRPK1	1.04817202
34	VRK1	1.04565783
35	INSRR	1.03368950
36	RPS6KA4	1.02779577
37	MAP4K1	0.99700913
38	FRK	0.97919593
39	NME1	0.92861888
40	MAPK13	0.87642300
41	CDK8	0.86095152
42	PLK1	0.85988854
43	TESK2	0.81931878
44	AURKA	0.80683410
45	CHEK2	0.77619883
46	CAMK1	0.76814217
47	RPS6KA5	0.75967680
48	OXSR1	0.75418538
49	PRKCQ	0.74701637
50	TLK1	0.72232381
51	MAPK15	0.71864420
52	LIMK1	0.69332510
53	PIM2	0.69161932
54	MAP2K7	0.68232327
55	CDK3	0.67152020
56	GRK6	0.66324286
57	WNK3	0.65567646
58	CASK	0.63877268
59	WEE1	0.63076650
60	AURKB	0.61686839
61	DAPK3	0.60985210
62	TIE1	0.60981524
63	CSNK2A2	0.60811279
64	PRKCG	0.59207210
65	CSNK1G1	0.58675418
66	CSNK1G2	0.57161306
67	CDK19	0.56557590
68	PLK3	0.56365211
69	MST4	0.56224371
70	TNIK	0.55250828
71	MAP3K11	0.51606811
72	CAMK4	0.51093786
73	NME2	0.51023506
74	SYK	0.50861429
75	DAPK1	0.50571872
76	MARK3	0.50482587
77	SIK2	0.50281569
78	BRSK2	0.49899402
79	CSNK2A1	0.49120709
80	PRKCI	0.48912619
81	CCNB1	0.47934864
82	ITK	0.47151999
83	DMPK	0.46600790
84	FES	0.45742861
85	CSNK1E	0.45582577
86	ATR	0.44942340
87	PIM1	0.43623433
88	BRSK1	0.41947478
89	ATM	0.41441806
90	CSNK1A1	0.40432882
91	CSNK1G3	0.40279838
92	GRK7	0.39921516
93	NTRK3	0.39492251
94	MKNK2	0.39171362
95	LRRK2	0.38374727
96	DAPK2	0.37709951
97	RPS6KB2	0.36969818
98	EIF2AK2	0.35846819
99	EPHA4	0.34805506
100	MINK1	0.33677926

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.95969448
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.91223766
3	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.35296018
4	Parkinsons disease_Homo sapiens_hsa05012	3.33073512
5	Proteasome_Homo sapiens_hsa03050	3.32496210
6	RNA polymerase_Homo sapiens_hsa03020	2.55065163
7	Huntingtons disease_Homo sapiens_hsa05016	2.39558141
8	Homologous recombination_Homo sapiens_hsa03440	2.37755121
9	Alzheimers disease_Homo sapiens_hsa05010	2.36202158
10	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.31187438
11	Protein export_Homo sapiens_hsa03060	2.13513209
12	Fanconi anemia pathway_Homo sapiens_hsa03460	2.07613958
13	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.06427320
14	Base excision repair_Homo sapiens_hsa03410	2.04999575
15	Primary immunodeficiency_Homo sapiens_hsa05340	1.99727320
16	Mismatch repair_Homo sapiens_hsa03430	1.92837196
17	Cardiac muscle contraction_Homo sapiens_hsa04260	1.81440635
18	DNA replication_Homo sapiens_hsa03030	1.81088870
19	One carbon pool by folate_Homo sapiens_hsa00670	1.79294088
20	Sulfur relay system_Homo sapiens_hsa04122	1.74156591
21	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.72567034
22	RNA degradation_Homo sapiens_hsa03018	1.67970628
23	Pyrimidine metabolism_Homo sapiens_hsa00240	1.62808691
24	Basal transcription factors_Homo sapiens_hsa03022	1.62643067
25	Nitrogen metabolism_Homo sapiens_hsa00910	1.40408452
26	Phototransduction_Homo sapiens_hsa04744	1.29223994
27	Propanoate metabolism_Homo sapiens_hsa00640	1.27952986
28	Purine metabolism_Homo sapiens_hsa00230	1.24882339
29	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.24711073
30	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.23062416
31	Nucleotide excision repair_Homo sapiens_hsa03420	1.21712250
32	Spliceosome_Homo sapiens_hsa03040	1.21135688
33	RNA transport_Homo sapiens_hsa03013	1.18917457
34	Peroxisome_Homo sapiens_hsa04146	1.18405481
35	Butanoate metabolism_Homo sapiens_hsa00650	1.08924565
36	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.05390977
37	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.02327403
38	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.00728206
39	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.00243624
40	Olfactory transduction_Homo sapiens_hsa04740	1.00018957
41	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.99340377
42	Glutathione metabolism_Homo sapiens_hsa00480	0.98478348
43	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.96335512
44	Linoleic acid metabolism_Homo sapiens_hsa00591	0.95751553
45	Retinol metabolism_Homo sapiens_hsa00830	0.95748837
46	Antigen processing and presentation_Homo sapiens_hsa04612	0.94547012
47	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.82969449
48	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.80511487
49	Chemical carcinogenesis_Homo sapiens_hsa05204	0.79815860
50	Caffeine metabolism_Homo sapiens_hsa00232	0.79499401
51	Graft-versus-host disease_Homo sapiens_hsa05332	0.74953167
52	Metabolic pathways_Homo sapiens_hsa01100	0.74253536
53	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.64256285
54	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.63488002
55	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.62200011
56	Tryptophan metabolism_Homo sapiens_hsa00380	0.61673271
57	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.60375115
58	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.58009523
59	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.57951634
60	Folate biosynthesis_Homo sapiens_hsa00790	0.57550114
61	Sulfur metabolism_Homo sapiens_hsa00920	0.56989979
62	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.55621360
63	Non-homologous end-joining_Homo sapiens_hsa03450	0.55217981
64	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.54489967
65	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.54170450
66	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.52313338
67	Salivary secretion_Homo sapiens_hsa04970	0.50321074
68	p53 signaling pathway_Homo sapiens_hsa04115	0.49063202
69	Pyruvate metabolism_Homo sapiens_hsa00620	0.48082954
70	Ether lipid metabolism_Homo sapiens_hsa00565	0.47795048
71	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.47544407
72	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.47307140
73	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.47254905
74	Selenocompound metabolism_Homo sapiens_hsa00450	0.45453545
75	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.44700720
76	Steroid biosynthesis_Homo sapiens_hsa00100	0.44554636
77	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.44461407
78	Arginine and proline metabolism_Homo sapiens_hsa00330	0.44098660
79	Fat digestion and absorption_Homo sapiens_hsa04975	0.42870007
80	Basal cell carcinoma_Homo sapiens_hsa05217	0.42869107
81	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.42824161
82	Nicotine addiction_Homo sapiens_hsa05033	0.42752782
83	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.42689093
84	Taste transduction_Homo sapiens_hsa04742	0.42498140
85	Allograft rejection_Homo sapiens_hsa05330	0.42254582
86	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.40726871
87	Fatty acid elongation_Homo sapiens_hsa00062	0.36056450
88	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.35860749
89	beta-Alanine metabolism_Homo sapiens_hsa00410	0.34010465
90	Asthma_Homo sapiens_hsa05310	0.32424465
91	Fatty acid degradation_Homo sapiens_hsa00071	0.32186152
92	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.32059494
93	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.30303353
94	Rheumatoid arthritis_Homo sapiens_hsa05323	0.29858754
95	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.28668977
96	Glycerolipid metabolism_Homo sapiens_hsa00561	0.27747243
97	Type I diabetes mellitus_Homo sapiens_hsa04940	0.27291586
98	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.26613347
99	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.25639399
100	Morphine addiction_Homo sapiens_hsa05032	0.25560253

SNRPEP4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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