SNRPEP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sequestering of actin monomers (GO:0042989)7.55965603
2protein neddylation (GO:0045116)5.67074733
3DNA deamination (GO:0045006)4.66941701
4base-excision repair, AP site formation (GO:0006285)4.45653453
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.39643731
6proteasome assembly (GO:0043248)4.33589644
7DNA double-strand break processing (GO:0000729)4.24792863
8platelet dense granule organization (GO:0060155)4.18809062
9iron-sulfur cluster assembly (GO:0016226)3.96346026
10metallo-sulfur cluster assembly (GO:0031163)3.96346026
11mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.94156111
12tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.86745961
13RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.86745961
14negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.83932621
15ubiquinone metabolic process (GO:0006743)3.82725482
16nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.81133973
17regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.77719040
18regulation of cellular amino acid metabolic process (GO:0006521)3.75098126
19ubiquinone biosynthetic process (GO:0006744)3.69693625
20respiratory electron transport chain (GO:0022904)3.65483474
21cytidine metabolic process (GO:0046087)3.61942407
22cytidine catabolic process (GO:0006216)3.61942407
23cytidine deamination (GO:0009972)3.61942407
24exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.61302062
25electron transport chain (GO:0022900)3.60256603
26DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.60060377
27regulation of development, heterochronic (GO:0040034)3.50897687
28energy coupled proton transport, down electrochemical gradient (GO:0015985)3.50218338
29ATP synthesis coupled proton transport (GO:0015986)3.50218338
30respiratory chain complex IV assembly (GO:0008535)3.49749440
31intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.48264638
32signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.48264638
33signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.47136337
34signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.47136337
35signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.47136337
36positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.41597545
37regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.40870975
38histone H2A acetylation (GO:0043968)3.39735172
39cullin deneddylation (GO:0010388)3.39327165
40Arp2/3 complex-mediated actin nucleation (GO:0034314)3.38447546
41negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.38323488
42negative regulation of ligase activity (GO:0051352)3.38323488
43establishment of protein localization to mitochondrial membrane (GO:0090151)3.37717863
44signal transduction involved in cell cycle checkpoint (GO:0072395)3.35425291
45mannosylation (GO:0097502)3.31947331
46signal transduction involved in DNA integrity checkpoint (GO:0072401)3.27136255
47signal transduction involved in DNA damage checkpoint (GO:0072422)3.27136255
48pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.22460250
49protein deneddylation (GO:0000338)3.20604664
50protein complex biogenesis (GO:0070271)3.18236196
51pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.14822750
52cytochrome complex assembly (GO:0017004)3.13540677
53anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.09199977
54quinone biosynthetic process (GO:1901663)3.08413560
55nonmotile primary cilium assembly (GO:0035058)3.05242853
56actin nucleation (GO:0045010)3.05011734
57deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.03145042
58forebrain neuron differentiation (GO:0021879)3.02230970
59histone mRNA metabolic process (GO:0008334)3.02021894
60chromatin remodeling at centromere (GO:0031055)3.01922754
61intraciliary transport (GO:0042073)2.98624483
62spliceosomal snRNP assembly (GO:0000387)2.98577204
63termination of RNA polymerase II transcription (GO:0006369)2.97390207
64protein-cofactor linkage (GO:0018065)2.95414813
65negative regulation of oligodendrocyte differentiation (GO:0048715)2.94817115
66DNA integration (GO:0015074)2.94277279
67positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.93437972
68negative regulation of transcription regulatory region DNA binding (GO:2000678)2.92864924
69regulation of mitochondrial translation (GO:0070129)2.91860045
70CENP-A containing nucleosome assembly (GO:0034080)2.91568956
71mitochondrial respiratory chain complex assembly (GO:0033108)2.90051551
72pyrimidine ribonucleoside catabolic process (GO:0046133)2.89718099
73antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.86489285
74mitochondrial respiratory chain complex I assembly (GO:0032981)2.85820140
75NADH dehydrogenase complex assembly (GO:0010257)2.85820140
76mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.85820140
77organelle disassembly (GO:1903008)2.83174884
78GPI anchor metabolic process (GO:0006505)2.83159202
79DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.82056049
80spinal cord association neuron differentiation (GO:0021527)2.81912430
81DNA catabolic process, exonucleolytic (GO:0000738)2.80882425
82regulation of timing of cell differentiation (GO:0048505)2.80239832
83regulation of cellular amine metabolic process (GO:0033238)2.77104175
84deoxyribonucleotide catabolic process (GO:0009264)2.76833789
85cholesterol biosynthetic process (GO:0006695)2.74760539
86ribonucleoprotein complex disassembly (GO:0032988)2.73175094
87RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.72581220
88positive regulation of ligase activity (GO:0051351)2.72147137
89DNA demethylation (GO:0080111)2.71942267
90DNA damage response, detection of DNA damage (GO:0042769)2.70914172
91deoxyribose phosphate biosynthetic process (GO:0046385)2.70591408
922-deoxyribonucleotide biosynthetic process (GO:0009265)2.70591408
93isoprenoid biosynthetic process (GO:0008299)2.70060535
94purine deoxyribonucleotide catabolic process (GO:0009155)2.69613474
95chaperone-mediated protein transport (GO:0072321)2.68874002
96positive regulation of oligodendrocyte differentiation (GO:0048714)2.67166123
97L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.66947526
98deoxyribonucleotide biosynthetic process (GO:0009263)2.65940399
99peptidyl-histidine modification (GO:0018202)2.64814844
100left/right axis specification (GO:0070986)2.64747135

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.10659717
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.97924017
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.42221644
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.20567196
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.19800245
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.00911402
7ZNF274_21170338_ChIP-Seq_K562_Hela2.95455846
8IGF1R_20145208_ChIP-Seq_DFB_Human2.93759193
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.90076994
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.83599814
11ELK1_19687146_ChIP-ChIP_HELA_Human2.64575681
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.53274938
13VDR_23849224_ChIP-Seq_CD4+_Human2.49198323
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.36076946
15VDR_22108803_ChIP-Seq_LS180_Human2.35199735
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.30662409
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.24991377
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.23963511
19EWS_26573619_Chip-Seq_HEK293_Human2.10886193
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.07008457
21SRF_21415370_ChIP-Seq_HL-1_Mouse2.05214664
22POU3F2_20337985_ChIP-ChIP_501MEL_Human2.03650209
23FLI1_27457419_Chip-Seq_LIVER_Mouse2.03549756
24FOXP3_21729870_ChIP-Seq_TREG_Human1.99641179
25TAF15_26573619_Chip-Seq_HEK293_Human1.90996292
26E2F4_17652178_ChIP-ChIP_JURKAT_Human1.84828581
27PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.80411261
28FUS_26573619_Chip-Seq_HEK293_Human1.80092122
29EZH2_22144423_ChIP-Seq_EOC_Human1.76873759
30GABP_19822575_ChIP-Seq_HepG2_Human1.75388274
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.75117760
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.73401702
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66738409
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.65569769
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.64748720
36E2F7_22180533_ChIP-Seq_HELA_Human1.57616324
37MYC_18940864_ChIP-ChIP_HL60_Human1.56051263
38PADI4_21655091_ChIP-ChIP_MCF-7_Human1.54842891
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.52203217
40SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.46792351
41PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46731553
42POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.41509336
43P300_19829295_ChIP-Seq_ESCs_Human1.41114601
44POU5F1_16153702_ChIP-ChIP_HESCs_Human1.40272568
45GBX2_23144817_ChIP-Seq_PC3_Human1.40055202
46TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38565124
47TP53_22573176_ChIP-Seq_HFKS_Human1.36935146
48FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.36771388
49ELK1_22589737_ChIP-Seq_MCF10A_Human1.34407549
50EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.33084638
51ER_23166858_ChIP-Seq_MCF-7_Human1.32366991
52PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.32020800
53IRF1_19129219_ChIP-ChIP_H3396_Human1.29599939
54CBP_20019798_ChIP-Seq_JUKART_Human1.28078872
55IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28078872
56MYC_18555785_ChIP-Seq_MESCs_Mouse1.26059528
57MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24974193
58NCOR_22424771_ChIP-Seq_293T_Human1.24522092
59MYC_18358816_ChIP-ChIP_MESCs_Mouse1.24263269
60ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.20154631
61AR_20517297_ChIP-Seq_VCAP_Human1.19596104
62DCP1A_22483619_ChIP-Seq_HELA_Human1.16515306
63GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16120369
64E2F1_18555785_ChIP-Seq_MESCs_Mouse1.15849748
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.14867225
66SOX2_18555785_ChIP-Seq_MESCs_Mouse1.14806106
67HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.13019979
68FOXA1_25329375_ChIP-Seq_VCAP_Human1.12769764
69FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12769764
70PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12024318
71KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10794370
72SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10689045
73AUTS2_25519132_ChIP-Seq_293T-REX_Human1.09530034
74CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.08918657
75UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08545916
76RNF2_27304074_Chip-Seq_NSC_Mouse1.08131727
77HTT_18923047_ChIP-ChIP_STHdh_Human1.08074892
78CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.07069340
79MYC_19030024_ChIP-ChIP_MESCs_Mouse1.06130837
80THAP11_20581084_ChIP-Seq_MESCs_Mouse1.04860349
81NFE2_27457419_Chip-Seq_LIVER_Mouse1.04404619
82CBX2_27304074_Chip-Seq_ESCs_Mouse1.03803173
83EZH2_27294783_Chip-Seq_NPCs_Mouse1.03548271
84NELFA_20434984_ChIP-Seq_ESCs_Mouse1.01888784
85YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00085838
86NOTCH1_21737748_ChIP-Seq_TLL_Human0.99995756
87FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99508539
88ERG_20517297_ChIP-Seq_VCAP_Human0.98808264
89CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.98264674
90TTF2_22483619_ChIP-Seq_HELA_Human0.92830908
91SOX2_19829295_ChIP-Seq_ESCs_Human0.92555026
92NANOG_19829295_ChIP-Seq_ESCs_Human0.92555026
93CRX_20693478_ChIP-Seq_RETINA_Mouse0.91336459
94YY1_21170310_ChIP-Seq_MESCs_Mouse0.89729988
95TAL1_26923725_Chip-Seq_HPCs_Mouse0.89303374
96NANOG_16153702_ChIP-ChIP_HESCs_Human0.88776253
97NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.88394706
98XRN2_22483619_ChIP-Seq_HELA_Human0.87170983
99SOX2_16153702_ChIP-ChIP_HESCs_Human0.87142742
100SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86217713

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.50663884
2MP0002102_abnormal_ear_morphology3.41290476
3MP0008789_abnormal_olfactory_epithelium3.33746682
4MP0006072_abnormal_retinal_apoptosis2.79739394
5MP0005394_taste/olfaction_phenotype2.58525371
6MP0005499_abnormal_olfactory_system2.58525371
7MP0001529_abnormal_vocalization2.39781091
8MP0008058_abnormal_DNA_repair2.39572736
9MP0002653_abnormal_ependyma_morphology2.31643001
10MP0005253_abnormal_eye_physiology2.31143856
11MP0006276_abnormal_autonomic_nervous2.15383420
12MP0005645_abnormal_hypothalamus_physiol2.13376960
13MP0005646_abnormal_pituitary_gland2.11139707
14MP0006292_abnormal_olfactory_placode2.07114819
15MP0000372_irregular_coat_pigmentation2.06963408
16MP0008995_early_reproductive_senescence2.01175796
17MP0003011_delayed_dark_adaptation1.93380943
18MP0008877_abnormal_DNA_methylation1.89602185
19MP0001984_abnormal_olfaction1.89416650
20MP0003122_maternal_imprinting1.81467248
21MP0006054_spinal_hemorrhage1.79387343
22MP0000049_abnormal_middle_ear1.75637143
23MP0002736_abnormal_nociception_after1.73912909
24MP0002234_abnormal_pharynx_morphology1.73228329
25MP0004133_heterotaxia1.67344401
26MP0003787_abnormal_imprinting1.61655910
27MP0003137_abnormal_impulse_conducting1.60653480
28MP0005671_abnormal_response_to1.58582304
29MP0001905_abnormal_dopamine_level1.57615528
30MP0005551_abnormal_eye_electrophysiolog1.54994815
31MP0004142_abnormal_muscle_tone1.54964975
32MP0004147_increased_porphyrin_level1.53740094
33MP0002837_dystrophic_cardiac_calcinosis1.52792961
34MP0000631_abnormal_neuroendocrine_gland1.51094803
35MP0006035_abnormal_mitochondrial_morpho1.50426835
36MP0005084_abnormal_gallbladder_morpholo1.48859035
37MP0008932_abnormal_embryonic_tissue1.48009646
38MP0003119_abnormal_digestive_system1.46571246
39MP0001968_abnormal_touch/_nociception1.39932983
40MP0003786_premature_aging1.39517294
41MP0005248_abnormal_Harderian_gland1.37578289
42MP0003646_muscle_fatigue1.37459604
43MP0010094_abnormal_chromosome_stability1.34368204
44MP0001764_abnormal_homeostasis1.33597960
45MP0001486_abnormal_startle_reflex1.32986969
46MP0003121_genomic_imprinting1.32040345
47MP0009046_muscle_twitch1.28042322
48MP0002090_abnormal_vision1.23642650
49MP0005389_reproductive_system_phenotype1.21652965
50MP0009745_abnormal_behavioral_response1.18436467
51MP0002272_abnormal_nervous_system1.16628093
52MP0001919_abnormal_reproductive_system1.16337712
53MP0002751_abnormal_autonomic_nervous1.15425447
54MP0002160_abnormal_reproductive_system1.13859769
55MP0008872_abnormal_physiological_respon1.12142087
56MP0003136_yellow_coat_color1.11448638
57MP0008961_abnormal_basal_metabolism1.09602424
58MP0003221_abnormal_cardiomyocyte_apopto1.08546170
59MP0002638_abnormal_pupillary_reflex1.08355691
60MP0000647_abnormal_sebaceous_gland1.03821418
61MP0006036_abnormal_mitochondrial_physio1.03517570
62MP0003195_calcinosis1.02904110
63MP0009697_abnormal_copulation1.00537604
64MP0004957_abnormal_blastocyst_morpholog0.99421228
65MP0001485_abnormal_pinna_reflex0.98414829
66MP0002572_abnormal_emotion/affect_behav0.98163759
67MP0005391_vision/eye_phenotype0.96161107
68MP0000026_abnormal_inner_ear0.93290468
69MP0004215_abnormal_myocardial_fiber0.92781260
70MP0005187_abnormal_penis_morphology0.91751315
71MP0003186_abnormal_redox_activity0.90734692
72MP0005367_renal/urinary_system_phenotyp0.90468415
73MP0000516_abnormal_urinary_system0.90468415
74MP0005171_absent_coat_pigmentation0.89912661
75MP0002752_abnormal_somatic_nervous0.88705403
76MP0002557_abnormal_social/conspecific_i0.86389860
77MP0003878_abnormal_ear_physiology0.85930555
78MP0005377_hearing/vestibular/ear_phenot0.85930555
79MP0001119_abnormal_female_reproductive0.82370307
80MP0001970_abnormal_pain_threshold0.82219268
81MP0000778_abnormal_nervous_system0.82072845
82MP0001293_anophthalmia0.81854335
83MP0005423_abnormal_somatic_nervous0.81727317
84MP0002233_abnormal_nose_morphology0.81402118
85MP0002733_abnormal_thermal_nociception0.80531050
86MP0005647_abnormal_sex_gland0.80230387
87MP0000751_myopathy0.79941527
88MP0005167_abnormal_blood-brain_barrier0.79921688
89MP0003937_abnormal_limbs/digits/tail_de0.78025927
90MP0005195_abnormal_posterior_eye0.77524794
91MP0002210_abnormal_sex_determination0.77356040
92MP0002184_abnormal_innervation0.75318762
93MP0004043_abnormal_pH_regulation0.74950679
94MP0000653_abnormal_sex_gland0.73762181
95MP0001963_abnormal_hearing_physiology0.73524819
96MP0008875_abnormal_xenobiotic_pharmacok0.72360531
97MP0003693_abnormal_embryo_hatching0.71182373
98MP0001929_abnormal_gametogenesis0.71094680
99MP0001188_hyperpigmentation0.70898873
100MP0002095_abnormal_skin_pigmentation0.70378502

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.24767464
2Abnormal mitochondria in muscle tissue (HP:0008316)3.85646377
3Mitochondrial inheritance (HP:0001427)3.75316302
4Acute encephalopathy (HP:0006846)3.75186137
5Abnormality of alanine metabolism (HP:0010916)3.69616820
6Hyperalaninemia (HP:0003348)3.69616820
7Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.69616820
8Progressive macrocephaly (HP:0004481)3.43155177
9Hepatocellular necrosis (HP:0001404)3.42042019
10Increased CSF lactate (HP:0002490)3.38039478
11Hyperglycinemia (HP:0002154)3.24879844
12Medial flaring of the eyebrow (HP:0010747)3.22047625
13True hermaphroditism (HP:0010459)3.20104572
14Hepatic necrosis (HP:0002605)3.17867997
15Pancreatic fibrosis (HP:0100732)3.11938842
16Pancreatic cysts (HP:0001737)3.08268324
17Colon cancer (HP:0003003)3.06346987
18Cerebral edema (HP:0002181)2.90908902
19Congenital primary aphakia (HP:0007707)2.86558643
20Renal cortical cysts (HP:0000803)2.84484615
21Gait imbalance (HP:0002141)2.82798974
22Abnormality of midbrain morphology (HP:0002418)2.79353069
23Molar tooth sign on MRI (HP:0002419)2.79353069
24Congenital stationary night blindness (HP:0007642)2.75473493
25Increased hepatocellular lipid droplets (HP:0006565)2.71432779
26Nephrogenic diabetes insipidus (HP:0009806)2.65452921
27Amyotrophic lateral sclerosis (HP:0007354)2.57911219
28Nephronophthisis (HP:0000090)2.52196149
29Abnormality of serum amino acid levels (HP:0003112)2.49630181
30Decreased electroretinogram (ERG) amplitude (HP:0000654)2.49258944
313-Methylglutaconic aciduria (HP:0003535)2.48850587
32Lactic acidosis (HP:0003128)2.48284164
33Lipid accumulation in hepatocytes (HP:0006561)2.47762974
34Methylmalonic acidemia (HP:0002912)2.44424814
35Split foot (HP:0001839)2.41217556
36Severe combined immunodeficiency (HP:0004430)2.40326607
37Decreased activity of mitochondrial respiratory chain (HP:0008972)2.37132074
38Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.37132074
39Respiratory failure (HP:0002878)2.36315623
40Optic disc pallor (HP:0000543)2.32805194
41Abnormality of the ileum (HP:0001549)2.29893768
42Increased serum lactate (HP:0002151)2.28637470
43Thyroid-stimulating hormone excess (HP:0002925)2.27143748
44Hypoproteinemia (HP:0003075)2.25436354
45Meckel diverticulum (HP:0002245)2.23143070
46Neonatal respiratory distress (HP:0002643)2.23105393
47Abnormality of the renal cortex (HP:0011035)2.21555653
48Methylmalonic aciduria (HP:0012120)2.20348848
49Abnormality of serine family amino acid metabolism (HP:0010894)2.19866308
50Abnormality of glycine metabolism (HP:0010895)2.19866308
51Eosinophilia (HP:0001880)2.18696852
52Increased IgM level (HP:0003496)2.16084756
53Abnormality of eosinophils (HP:0001879)2.14710603
54Abnormality of the renal medulla (HP:0100957)2.14708114
55Renal Fanconi syndrome (HP:0001994)2.13884296
56Failure to thrive in infancy (HP:0001531)2.11931994
57Atrophy/Degeneration involving motor neurons (HP:0007373)2.08658941
58Vaginal atresia (HP:0000148)2.07701586
59Genital tract atresia (HP:0001827)2.07030813
60Postaxial foot polydactyly (HP:0001830)2.06927118
61Abnormality of the labia minora (HP:0012880)2.06332832
62Attenuation of retinal blood vessels (HP:0007843)2.03410223
63Congenital, generalized hypertrichosis (HP:0004540)2.03135809
64Increased intramyocellular lipid droplets (HP:0012240)2.03063731
65Sclerocornea (HP:0000647)1.99086830
66Short tibia (HP:0005736)1.98523231
67Pendular nystagmus (HP:0012043)1.98307725
68Abnormality of B cell number (HP:0010975)1.98184860
69Aplasia/Hypoplasia of the uvula (HP:0010293)1.97129170
70Hyperglycinuria (HP:0003108)1.96404776
71Postaxial hand polydactyly (HP:0001162)1.95637120
72Aplasia/Hypoplasia of the tibia (HP:0005772)1.94967242
73Lethargy (HP:0001254)1.94631574
74Aplastic anemia (HP:0001915)1.93169790
75Dicarboxylic aciduria (HP:0003215)1.93017526
76Abnormality of dicarboxylic acid metabolism (HP:0010995)1.93017526
77IgG deficiency (HP:0004315)1.92915036
78Agitation (HP:0000713)1.92573993
79Combined immunodeficiency (HP:0005387)1.91483231
80Type 2 muscle fiber atrophy (HP:0003554)1.89711288
81Decreased central vision (HP:0007663)1.89086983
82Type I transferrin isoform profile (HP:0003642)1.88713618
83Thyroiditis (HP:0100646)1.87745521
84Supernumerary spleens (HP:0009799)1.87464379
85Broad foot (HP:0001769)1.85650676
86Leukodystrophy (HP:0002415)1.82575008
87Retinal dysplasia (HP:0007973)1.80912023
88Aplasia/Hypoplasia of the tongue (HP:0010295)1.80889288
89Intestinal atresia (HP:0011100)1.80494083
90Type II lissencephaly (HP:0007260)1.79551531
91Delayed CNS myelination (HP:0002188)1.79095453
92Poor coordination (HP:0002370)1.78602545
93Increased serum pyruvate (HP:0003542)1.78402766
94Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.78032269
95CNS demyelination (HP:0007305)1.77578874
96Absent rod-and cone-mediated responses on ERG (HP:0007688)1.76284717
97Lissencephaly (HP:0001339)1.76144674
98Abnormality of secondary sexual hair (HP:0009888)1.75043693
99Abnormality of the axillary hair (HP:0100134)1.75043693
100Abnormal glycosylation (HP:0012345)1.74862043

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCR3.74418529
2KDR3.65388869
3MAP4K23.53802950
4SRPK13.05284014
5MAP2K73.04675028
6WNK32.69870480
7TRIM282.56033288
8BCKDK2.49283399
9ERBB32.33727699
10MAP3K42.29959185
11TESK22.24747349
12ZAK2.05853670
13VRK22.00420042
14CSNK1G31.97496149
15MAPK131.84135229
16RPS6KA41.79713202
17PINK11.77325466
18CSNK1A1L1.76235049
19BUB11.75587874
20CSNK1G21.70475915
21STK161.67358332
22EPHA31.64405659
23CSNK1G11.61217026
24LIMK11.56667603
25TESK11.56568989
26VRK11.53797496
27EPHA41.32875884
28ADRBK21.30624678
29PLK21.29049421
30CAMKK21.22771308
31PLK41.16577395
32GRK11.13732978
33TXK1.07497973
34TIE11.06973175
35UHMK11.06550974
36INSRR1.05149670
37CDC70.98082508
38FRK0.95596032
39EIF2AK30.94859934
40PIM20.93544505
41CCNB10.92647912
42RPS6KA50.91479438
43MUSK0.90258370
44MAP3K50.89557159
45DYRK20.89153055
46MKNK10.88535437
47TLK10.87265605
48ITK0.84918855
49NUAK10.80190144
50PASK0.80152699
51TNK20.79615998
52PLK10.75126462
53BRSK20.74783074
54TAOK10.66199792
55CASK0.65658757
56BMPR1B0.64013418
57PLK30.62815891
58PRKD30.62656391
59NME10.61794437
60PRKCE0.59445791
61SIK30.59109747
62MINK10.56566713
63CDK140.55299991
64MARK10.54720133
65PKN10.54230113
66DYRK1B0.54141318
67CAMK2A0.51417563
68CSNK2A10.50748989
69MAP3K120.49550715
70CSNK1A10.49110988
71WEE10.49109349
72CAMKK10.46486932
73ATR0.45554983
74PRKCG0.45322517
75PAK40.45294755
76AURKB0.44962564
77MST40.44563991
78MAP2K40.44482330
79PAK30.44377126
80OBSCN0.42968937
81TEC0.41863799
82AURKA0.41704369
83CDK180.40979239
84CSNK1D0.38430458
85PRKACA0.37911045
86NEK10.37295014
87CAMK2B0.37049268
88BRSK10.36797559
89MYLK0.35160169
90PRKCQ0.34592025
91CDK150.33173337
92DYRK1A0.32906016
93CSNK2A20.30533679
94SCYL20.30487745
95EIF2AK10.29759109
96BTK0.29048390
97CAMK2G0.29038527
98GRK70.28726466
99CDK11A0.27563864
100PRKCA0.25275958

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.71633419
2Oxidative phosphorylation_Homo sapiens_hsa001903.65597944
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.28987636
4Protein export_Homo sapiens_hsa030603.10524228
5Parkinsons disease_Homo sapiens_hsa050123.06078651
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.46369284
7Propanoate metabolism_Homo sapiens_hsa006402.44830490
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.26369207
9Mismatch repair_Homo sapiens_hsa034302.20692077
10DNA replication_Homo sapiens_hsa030302.19949138
11RNA polymerase_Homo sapiens_hsa030202.15999953
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.15790678
13Steroid biosynthesis_Homo sapiens_hsa001002.12631556
14Huntingtons disease_Homo sapiens_hsa050162.07194006
15Fanconi anemia pathway_Homo sapiens_hsa034601.98817542
16Base excision repair_Homo sapiens_hsa034101.93182547
17Spliceosome_Homo sapiens_hsa030401.92623059
18Alzheimers disease_Homo sapiens_hsa050101.91369168
19Primary immunodeficiency_Homo sapiens_hsa053401.91055993
20Homologous recombination_Homo sapiens_hsa034401.91026006
21Butanoate metabolism_Homo sapiens_hsa006501.79890492
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.66843073
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.62365727
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.62220971
25Phototransduction_Homo sapiens_hsa047441.49973918
26Nucleotide excision repair_Homo sapiens_hsa034201.48980705
27Pyruvate metabolism_Homo sapiens_hsa006201.39730012
28RNA degradation_Homo sapiens_hsa030181.38590514
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.37479587
30Cardiac muscle contraction_Homo sapiens_hsa042601.36355408
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.30787936
32Pyrimidine metabolism_Homo sapiens_hsa002401.23610152
33Basal transcription factors_Homo sapiens_hsa030221.23335826
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.19953239
35Peroxisome_Homo sapiens_hsa041461.16431370
36Non-homologous end-joining_Homo sapiens_hsa034501.06074520
37Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.05409698
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.01152630
39RNA transport_Homo sapiens_hsa030130.97048744
40Nicotine addiction_Homo sapiens_hsa050330.93866769
41Purine metabolism_Homo sapiens_hsa002300.92055306
42Retinol metabolism_Homo sapiens_hsa008300.90093276
43Fatty acid elongation_Homo sapiens_hsa000620.87534373
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86403684
45Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84870046
46Taste transduction_Homo sapiens_hsa047420.82713465
47Tryptophan metabolism_Homo sapiens_hsa003800.81873872
48Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.81002263
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80061334
50Ribosome_Homo sapiens_hsa030100.79254313
51Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.75905519
52Metabolic pathways_Homo sapiens_hsa011000.73721394
53Folate biosynthesis_Homo sapiens_hsa007900.73264196
54Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.72278488
55Nitrogen metabolism_Homo sapiens_hsa009100.71933945
56Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.70483829
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70304944
58Collecting duct acid secretion_Homo sapiens_hsa049660.70028682
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68179721
60beta-Alanine metabolism_Homo sapiens_hsa004100.63272874
61Sulfur metabolism_Homo sapiens_hsa009200.61519536
62Steroid hormone biosynthesis_Homo sapiens_hsa001400.60131670
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59378010
64GABAergic synapse_Homo sapiens_hsa047270.58611277
65Olfactory transduction_Homo sapiens_hsa047400.58336104
66mRNA surveillance pathway_Homo sapiens_hsa030150.57086091
67Linoleic acid metabolism_Homo sapiens_hsa005910.56906248
68Chemical carcinogenesis_Homo sapiens_hsa052040.56012556
69Caffeine metabolism_Homo sapiens_hsa002320.55735710
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55326720
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54300145
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53009694
73Carbon metabolism_Homo sapiens_hsa012000.52539562
74Fatty acid metabolism_Homo sapiens_hsa012120.52290529
75Shigellosis_Homo sapiens_hsa051310.50630208
76Cell cycle_Homo sapiens_hsa041100.50334049
77Morphine addiction_Homo sapiens_hsa050320.50315781
78Biosynthesis of amino acids_Homo sapiens_hsa012300.46599518
79Antigen processing and presentation_Homo sapiens_hsa046120.45318875
80Oocyte meiosis_Homo sapiens_hsa041140.44438050
81Hematopoietic cell lineage_Homo sapiens_hsa046400.44196065
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.44096207
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41874633
84Fatty acid degradation_Homo sapiens_hsa000710.40967042
85Glutathione metabolism_Homo sapiens_hsa004800.38810468
86Drug metabolism - other enzymes_Homo sapiens_hsa009830.38101073
87Alcoholism_Homo sapiens_hsa050340.37201076
88Fat digestion and absorption_Homo sapiens_hsa049750.33763860
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31009994
90Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.30027951
91Sulfur relay system_Homo sapiens_hsa041220.28647365
92Tyrosine metabolism_Homo sapiens_hsa003500.27797284
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.27626991
94Salmonella infection_Homo sapiens_hsa051320.26381351
95One carbon pool by folate_Homo sapiens_hsa006700.25499204
96Graft-versus-host disease_Homo sapiens_hsa053320.24061213
97Primary bile acid biosynthesis_Homo sapiens_hsa001200.22981200
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.20956939
99Ether lipid metabolism_Homo sapiens_hsa005650.20823577
100Phenylalanine metabolism_Homo sapiens_hsa003600.20472913

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