

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | sequestering of actin monomers (GO:0042989) | 7.55965603 |
| 2 | protein neddylation (GO:0045116) | 5.67074733 |
| 3 | DNA deamination (GO:0045006) | 4.66941701 |
| 4 | base-excision repair, AP site formation (GO:0006285) | 4.45653453 |
| 5 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.39643731 |
| 6 | proteasome assembly (GO:0043248) | 4.33589644 |
| 7 | DNA double-strand break processing (GO:0000729) | 4.24792863 |
| 8 | platelet dense granule organization (GO:0060155) | 4.18809062 |
| 9 | iron-sulfur cluster assembly (GO:0016226) | 3.96346026 |
| 10 | metallo-sulfur cluster assembly (GO:0031163) | 3.96346026 |
| 11 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.94156111 |
| 12 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.86745961 |
| 13 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.86745961 |
| 14 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.83932621 |
| 15 | ubiquinone metabolic process (GO:0006743) | 3.82725482 |
| 16 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.81133973 |
| 17 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.77719040 |
| 18 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.75098126 |
| 19 | ubiquinone biosynthetic process (GO:0006744) | 3.69693625 |
| 20 | respiratory electron transport chain (GO:0022904) | 3.65483474 |
| 21 | cytidine metabolic process (GO:0046087) | 3.61942407 |
| 22 | cytidine catabolic process (GO:0006216) | 3.61942407 |
| 23 | cytidine deamination (GO:0009972) | 3.61942407 |
| 24 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.61302062 |
| 25 | electron transport chain (GO:0022900) | 3.60256603 |
| 26 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.60060377 |
| 27 | regulation of development, heterochronic (GO:0040034) | 3.50897687 |
| 28 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.50218338 |
| 29 | ATP synthesis coupled proton transport (GO:0015986) | 3.50218338 |
| 30 | respiratory chain complex IV assembly (GO:0008535) | 3.49749440 |
| 31 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.48264638 |
| 32 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.48264638 |
| 33 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.47136337 |
| 34 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.47136337 |
| 35 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.47136337 |
| 36 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.41597545 |
| 37 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.40870975 |
| 38 | histone H2A acetylation (GO:0043968) | 3.39735172 |
| 39 | cullin deneddylation (GO:0010388) | 3.39327165 |
| 40 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 3.38447546 |
| 41 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.38323488 |
| 42 | negative regulation of ligase activity (GO:0051352) | 3.38323488 |
| 43 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.37717863 |
| 44 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.35425291 |
| 45 | mannosylation (GO:0097502) | 3.31947331 |
| 46 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.27136255 |
| 47 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.27136255 |
| 48 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.22460250 |
| 49 | protein deneddylation (GO:0000338) | 3.20604664 |
| 50 | protein complex biogenesis (GO:0070271) | 3.18236196 |
| 51 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 3.14822750 |
| 52 | cytochrome complex assembly (GO:0017004) | 3.13540677 |
| 53 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.09199977 |
| 54 | quinone biosynthetic process (GO:1901663) | 3.08413560 |
| 55 | nonmotile primary cilium assembly (GO:0035058) | 3.05242853 |
| 56 | actin nucleation (GO:0045010) | 3.05011734 |
| 57 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.03145042 |
| 58 | forebrain neuron differentiation (GO:0021879) | 3.02230970 |
| 59 | histone mRNA metabolic process (GO:0008334) | 3.02021894 |
| 60 | chromatin remodeling at centromere (GO:0031055) | 3.01922754 |
| 61 | intraciliary transport (GO:0042073) | 2.98624483 |
| 62 | spliceosomal snRNP assembly (GO:0000387) | 2.98577204 |
| 63 | termination of RNA polymerase II transcription (GO:0006369) | 2.97390207 |
| 64 | protein-cofactor linkage (GO:0018065) | 2.95414813 |
| 65 | negative regulation of oligodendrocyte differentiation (GO:0048715) | 2.94817115 |
| 66 | DNA integration (GO:0015074) | 2.94277279 |
| 67 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.93437972 |
| 68 | negative regulation of transcription regulatory region DNA binding (GO:2000678) | 2.92864924 |
| 69 | regulation of mitochondrial translation (GO:0070129) | 2.91860045 |
| 70 | CENP-A containing nucleosome assembly (GO:0034080) | 2.91568956 |
| 71 | mitochondrial respiratory chain complex assembly (GO:0033108) | 2.90051551 |
| 72 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 2.89718099 |
| 73 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 2.86489285 |
| 74 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 2.85820140 |
| 75 | NADH dehydrogenase complex assembly (GO:0010257) | 2.85820140 |
| 76 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 2.85820140 |
| 77 | organelle disassembly (GO:1903008) | 2.83174884 |
| 78 | GPI anchor metabolic process (GO:0006505) | 2.83159202 |
| 79 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 2.82056049 |
| 80 | spinal cord association neuron differentiation (GO:0021527) | 2.81912430 |
| 81 | DNA catabolic process, exonucleolytic (GO:0000738) | 2.80882425 |
| 82 | regulation of timing of cell differentiation (GO:0048505) | 2.80239832 |
| 83 | regulation of cellular amine metabolic process (GO:0033238) | 2.77104175 |
| 84 | deoxyribonucleotide catabolic process (GO:0009264) | 2.76833789 |
| 85 | cholesterol biosynthetic process (GO:0006695) | 2.74760539 |
| 86 | ribonucleoprotein complex disassembly (GO:0032988) | 2.73175094 |
| 87 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 2.72581220 |
| 88 | positive regulation of ligase activity (GO:0051351) | 2.72147137 |
| 89 | DNA demethylation (GO:0080111) | 2.71942267 |
| 90 | DNA damage response, detection of DNA damage (GO:0042769) | 2.70914172 |
| 91 | deoxyribose phosphate biosynthetic process (GO:0046385) | 2.70591408 |
| 92 | 2-deoxyribonucleotide biosynthetic process (GO:0009265) | 2.70591408 |
| 93 | isoprenoid biosynthetic process (GO:0008299) | 2.70060535 |
| 94 | purine deoxyribonucleotide catabolic process (GO:0009155) | 2.69613474 |
| 95 | chaperone-mediated protein transport (GO:0072321) | 2.68874002 |
| 96 | positive regulation of oligodendrocyte differentiation (GO:0048714) | 2.67166123 |
| 97 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 2.66947526 |
| 98 | deoxyribonucleotide biosynthetic process (GO:0009263) | 2.65940399 |
| 99 | peptidyl-histidine modification (GO:0018202) | 2.64814844 |
| 100 | left/right axis specification (GO:0070986) | 2.64747135 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.10659717 |
| 2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.97924017 |
| 3 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.42221644 |
| 4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.20567196 |
| 5 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.19800245 |
| 6 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 3.00911402 |
| 7 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.95455846 |
| 8 | IGF1R_20145208_ChIP-Seq_DFB_Human | 2.93759193 |
| 9 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.90076994 |
| 10 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.83599814 |
| 11 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.64575681 |
| 12 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.53274938 |
| 13 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.49198323 |
| 14 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.36076946 |
| 15 | VDR_22108803_ChIP-Seq_LS180_Human | 2.35199735 |
| 16 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.30662409 |
| 17 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.24991377 |
| 18 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.23963511 |
| 19 | EWS_26573619_Chip-Seq_HEK293_Human | 2.10886193 |
| 20 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.07008457 |
| 21 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.05214664 |
| 22 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 2.03650209 |
| 23 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.03549756 |
| 24 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.99641179 |
| 25 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.90996292 |
| 26 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.84828581 |
| 27 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.80411261 |
| 28 | FUS_26573619_Chip-Seq_HEK293_Human | 1.80092122 |
| 29 | EZH2_22144423_ChIP-Seq_EOC_Human | 1.76873759 |
| 30 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.75388274 |
| 31 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.75117760 |
| 32 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.73401702 |
| 33 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.66738409 |
| 34 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.65569769 |
| 35 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.64748720 |
| 36 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.57616324 |
| 37 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.56051263 |
| 38 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.54842891 |
| 39 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.52203217 |
| 40 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.46792351 |
| 41 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.46731553 |
| 42 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.41509336 |
| 43 | P300_19829295_ChIP-Seq_ESCs_Human | 1.41114601 |
| 44 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.40272568 |
| 45 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.40055202 |
| 46 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.38565124 |
| 47 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.36935146 |
| 48 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 1.36771388 |
| 49 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.34407549 |
| 50 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.33084638 |
| 51 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.32366991 |
| 52 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.32020800 |
| 53 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.29599939 |
| 54 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.28078872 |
| 55 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.28078872 |
| 56 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.26059528 |
| 57 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.24974193 |
| 58 | NCOR_22424771_ChIP-Seq_293T_Human | 1.24522092 |
| 59 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.24263269 |
| 60 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.20154631 |
| 61 | AR_20517297_ChIP-Seq_VCAP_Human | 1.19596104 |
| 62 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.16515306 |
| 63 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.16120369 |
| 64 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.15849748 |
| 65 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.14867225 |
| 66 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.14806106 |
| 67 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.13019979 |
| 68 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.12769764 |
| 69 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.12769764 |
| 70 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.12024318 |
| 71 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 1.10794370 |
| 72 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.10689045 |
| 73 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 1.09530034 |
| 74 | CEBPA_26348894_ChIP-Seq_LIVER_Mouse | 1.08918657 |
| 75 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.08545916 |
| 76 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.08131727 |
| 77 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.08074892 |
| 78 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.07069340 |
| 79 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.06130837 |
| 80 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.04860349 |
| 81 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.04404619 |
| 82 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.03803173 |
| 83 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.03548271 |
| 84 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.01888784 |
| 85 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.00085838 |
| 86 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.99995756 |
| 87 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 0.99508539 |
| 88 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.98808264 |
| 89 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.98264674 |
| 90 | TTF2_22483619_ChIP-Seq_HELA_Human | 0.92830908 |
| 91 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.92555026 |
| 92 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.92555026 |
| 93 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 0.91336459 |
| 94 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 0.89729988 |
| 95 | TAL1_26923725_Chip-Seq_HPCs_Mouse | 0.89303374 |
| 96 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.88776253 |
| 97 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 0.88394706 |
| 98 | XRN2_22483619_ChIP-Seq_HELA_Human | 0.87170983 |
| 99 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.87142742 |
| 100 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.86217713 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003880_abnormal_central_pattern | 3.50663884 |
| 2 | MP0002102_abnormal_ear_morphology | 3.41290476 |
| 3 | MP0008789_abnormal_olfactory_epithelium | 3.33746682 |
| 4 | MP0006072_abnormal_retinal_apoptosis | 2.79739394 |
| 5 | MP0005394_taste/olfaction_phenotype | 2.58525371 |
| 6 | MP0005499_abnormal_olfactory_system | 2.58525371 |
| 7 | MP0001529_abnormal_vocalization | 2.39781091 |
| 8 | MP0008058_abnormal_DNA_repair | 2.39572736 |
| 9 | MP0002653_abnormal_ependyma_morphology | 2.31643001 |
| 10 | MP0005253_abnormal_eye_physiology | 2.31143856 |
| 11 | MP0006276_abnormal_autonomic_nervous | 2.15383420 |
| 12 | MP0005645_abnormal_hypothalamus_physiol | 2.13376960 |
| 13 | MP0005646_abnormal_pituitary_gland | 2.11139707 |
| 14 | MP0006292_abnormal_olfactory_placode | 2.07114819 |
| 15 | MP0000372_irregular_coat_pigmentation | 2.06963408 |
| 16 | MP0008995_early_reproductive_senescence | 2.01175796 |
| 17 | MP0003011_delayed_dark_adaptation | 1.93380943 |
| 18 | MP0008877_abnormal_DNA_methylation | 1.89602185 |
| 19 | MP0001984_abnormal_olfaction | 1.89416650 |
| 20 | MP0003122_maternal_imprinting | 1.81467248 |
| 21 | MP0006054_spinal_hemorrhage | 1.79387343 |
| 22 | MP0000049_abnormal_middle_ear | 1.75637143 |
| 23 | MP0002736_abnormal_nociception_after | 1.73912909 |
| 24 | MP0002234_abnormal_pharynx_morphology | 1.73228329 |
| 25 | MP0004133_heterotaxia | 1.67344401 |
| 26 | MP0003787_abnormal_imprinting | 1.61655910 |
| 27 | MP0003137_abnormal_impulse_conducting | 1.60653480 |
| 28 | MP0005671_abnormal_response_to | 1.58582304 |
| 29 | MP0001905_abnormal_dopamine_level | 1.57615528 |
| 30 | MP0005551_abnormal_eye_electrophysiolog | 1.54994815 |
| 31 | MP0004142_abnormal_muscle_tone | 1.54964975 |
| 32 | MP0004147_increased_porphyrin_level | 1.53740094 |
| 33 | MP0002837_dystrophic_cardiac_calcinosis | 1.52792961 |
| 34 | MP0000631_abnormal_neuroendocrine_gland | 1.51094803 |
| 35 | MP0006035_abnormal_mitochondrial_morpho | 1.50426835 |
| 36 | MP0005084_abnormal_gallbladder_morpholo | 1.48859035 |
| 37 | MP0008932_abnormal_embryonic_tissue | 1.48009646 |
| 38 | MP0003119_abnormal_digestive_system | 1.46571246 |
| 39 | MP0001968_abnormal_touch/_nociception | 1.39932983 |
| 40 | MP0003786_premature_aging | 1.39517294 |
| 41 | MP0005248_abnormal_Harderian_gland | 1.37578289 |
| 42 | MP0003646_muscle_fatigue | 1.37459604 |
| 43 | MP0010094_abnormal_chromosome_stability | 1.34368204 |
| 44 | MP0001764_abnormal_homeostasis | 1.33597960 |
| 45 | MP0001486_abnormal_startle_reflex | 1.32986969 |
| 46 | MP0003121_genomic_imprinting | 1.32040345 |
| 47 | MP0009046_muscle_twitch | 1.28042322 |
| 48 | MP0002090_abnormal_vision | 1.23642650 |
| 49 | MP0005389_reproductive_system_phenotype | 1.21652965 |
| 50 | MP0009745_abnormal_behavioral_response | 1.18436467 |
| 51 | MP0002272_abnormal_nervous_system | 1.16628093 |
| 52 | MP0001919_abnormal_reproductive_system | 1.16337712 |
| 53 | MP0002751_abnormal_autonomic_nervous | 1.15425447 |
| 54 | MP0002160_abnormal_reproductive_system | 1.13859769 |
| 55 | MP0008872_abnormal_physiological_respon | 1.12142087 |
| 56 | MP0003136_yellow_coat_color | 1.11448638 |
| 57 | MP0008961_abnormal_basal_metabolism | 1.09602424 |
| 58 | MP0003221_abnormal_cardiomyocyte_apopto | 1.08546170 |
| 59 | MP0002638_abnormal_pupillary_reflex | 1.08355691 |
| 60 | MP0000647_abnormal_sebaceous_gland | 1.03821418 |
| 61 | MP0006036_abnormal_mitochondrial_physio | 1.03517570 |
| 62 | MP0003195_calcinosis | 1.02904110 |
| 63 | MP0009697_abnormal_copulation | 1.00537604 |
| 64 | MP0004957_abnormal_blastocyst_morpholog | 0.99421228 |
| 65 | MP0001485_abnormal_pinna_reflex | 0.98414829 |
| 66 | MP0002572_abnormal_emotion/affect_behav | 0.98163759 |
| 67 | MP0005391_vision/eye_phenotype | 0.96161107 |
| 68 | MP0000026_abnormal_inner_ear | 0.93290468 |
| 69 | MP0004215_abnormal_myocardial_fiber | 0.92781260 |
| 70 | MP0005187_abnormal_penis_morphology | 0.91751315 |
| 71 | MP0003186_abnormal_redox_activity | 0.90734692 |
| 72 | MP0005367_renal/urinary_system_phenotyp | 0.90468415 |
| 73 | MP0000516_abnormal_urinary_system | 0.90468415 |
| 74 | MP0005171_absent_coat_pigmentation | 0.89912661 |
| 75 | MP0002752_abnormal_somatic_nervous | 0.88705403 |
| 76 | MP0002557_abnormal_social/conspecific_i | 0.86389860 |
| 77 | MP0003878_abnormal_ear_physiology | 0.85930555 |
| 78 | MP0005377_hearing/vestibular/ear_phenot | 0.85930555 |
| 79 | MP0001119_abnormal_female_reproductive | 0.82370307 |
| 80 | MP0001970_abnormal_pain_threshold | 0.82219268 |
| 81 | MP0000778_abnormal_nervous_system | 0.82072845 |
| 82 | MP0001293_anophthalmia | 0.81854335 |
| 83 | MP0005423_abnormal_somatic_nervous | 0.81727317 |
| 84 | MP0002233_abnormal_nose_morphology | 0.81402118 |
| 85 | MP0002733_abnormal_thermal_nociception | 0.80531050 |
| 86 | MP0005647_abnormal_sex_gland | 0.80230387 |
| 87 | MP0000751_myopathy | 0.79941527 |
| 88 | MP0005167_abnormal_blood-brain_barrier | 0.79921688 |
| 89 | MP0003937_abnormal_limbs/digits/tail_de | 0.78025927 |
| 90 | MP0005195_abnormal_posterior_eye | 0.77524794 |
| 91 | MP0002210_abnormal_sex_determination | 0.77356040 |
| 92 | MP0002184_abnormal_innervation | 0.75318762 |
| 93 | MP0004043_abnormal_pH_regulation | 0.74950679 |
| 94 | MP0000653_abnormal_sex_gland | 0.73762181 |
| 95 | MP0001963_abnormal_hearing_physiology | 0.73524819 |
| 96 | MP0008875_abnormal_xenobiotic_pharmacok | 0.72360531 |
| 97 | MP0003693_abnormal_embryo_hatching | 0.71182373 |
| 98 | MP0001929_abnormal_gametogenesis | 0.71094680 |
| 99 | MP0001188_hyperpigmentation | 0.70898873 |
| 100 | MP0002095_abnormal_skin_pigmentation | 0.70378502 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 4.24767464 |
| 2 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.85646377 |
| 3 | Mitochondrial inheritance (HP:0001427) | 3.75316302 |
| 4 | Acute encephalopathy (HP:0006846) | 3.75186137 |
| 5 | Abnormality of alanine metabolism (HP:0010916) | 3.69616820 |
| 6 | Hyperalaninemia (HP:0003348) | 3.69616820 |
| 7 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 3.69616820 |
| 8 | Progressive macrocephaly (HP:0004481) | 3.43155177 |
| 9 | Hepatocellular necrosis (HP:0001404) | 3.42042019 |
| 10 | Increased CSF lactate (HP:0002490) | 3.38039478 |
| 11 | Hyperglycinemia (HP:0002154) | 3.24879844 |
| 12 | Medial flaring of the eyebrow (HP:0010747) | 3.22047625 |
| 13 | True hermaphroditism (HP:0010459) | 3.20104572 |
| 14 | Hepatic necrosis (HP:0002605) | 3.17867997 |
| 15 | Pancreatic fibrosis (HP:0100732) | 3.11938842 |
| 16 | Pancreatic cysts (HP:0001737) | 3.08268324 |
| 17 | Colon cancer (HP:0003003) | 3.06346987 |
| 18 | Cerebral edema (HP:0002181) | 2.90908902 |
| 19 | Congenital primary aphakia (HP:0007707) | 2.86558643 |
| 20 | Renal cortical cysts (HP:0000803) | 2.84484615 |
| 21 | Gait imbalance (HP:0002141) | 2.82798974 |
| 22 | Abnormality of midbrain morphology (HP:0002418) | 2.79353069 |
| 23 | Molar tooth sign on MRI (HP:0002419) | 2.79353069 |
| 24 | Congenital stationary night blindness (HP:0007642) | 2.75473493 |
| 25 | Increased hepatocellular lipid droplets (HP:0006565) | 2.71432779 |
| 26 | Nephrogenic diabetes insipidus (HP:0009806) | 2.65452921 |
| 27 | Amyotrophic lateral sclerosis (HP:0007354) | 2.57911219 |
| 28 | Nephronophthisis (HP:0000090) | 2.52196149 |
| 29 | Abnormality of serum amino acid levels (HP:0003112) | 2.49630181 |
| 30 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.49258944 |
| 31 | 3-Methylglutaconic aciduria (HP:0003535) | 2.48850587 |
| 32 | Lactic acidosis (HP:0003128) | 2.48284164 |
| 33 | Lipid accumulation in hepatocytes (HP:0006561) | 2.47762974 |
| 34 | Methylmalonic acidemia (HP:0002912) | 2.44424814 |
| 35 | Split foot (HP:0001839) | 2.41217556 |
| 36 | Severe combined immunodeficiency (HP:0004430) | 2.40326607 |
| 37 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.37132074 |
| 38 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.37132074 |
| 39 | Respiratory failure (HP:0002878) | 2.36315623 |
| 40 | Optic disc pallor (HP:0000543) | 2.32805194 |
| 41 | Abnormality of the ileum (HP:0001549) | 2.29893768 |
| 42 | Increased serum lactate (HP:0002151) | 2.28637470 |
| 43 | Thyroid-stimulating hormone excess (HP:0002925) | 2.27143748 |
| 44 | Hypoproteinemia (HP:0003075) | 2.25436354 |
| 45 | Meckel diverticulum (HP:0002245) | 2.23143070 |
| 46 | Neonatal respiratory distress (HP:0002643) | 2.23105393 |
| 47 | Abnormality of the renal cortex (HP:0011035) | 2.21555653 |
| 48 | Methylmalonic aciduria (HP:0012120) | 2.20348848 |
| 49 | Abnormality of serine family amino acid metabolism (HP:0010894) | 2.19866308 |
| 50 | Abnormality of glycine metabolism (HP:0010895) | 2.19866308 |
| 51 | Eosinophilia (HP:0001880) | 2.18696852 |
| 52 | Increased IgM level (HP:0003496) | 2.16084756 |
| 53 | Abnormality of eosinophils (HP:0001879) | 2.14710603 |
| 54 | Abnormality of the renal medulla (HP:0100957) | 2.14708114 |
| 55 | Renal Fanconi syndrome (HP:0001994) | 2.13884296 |
| 56 | Failure to thrive in infancy (HP:0001531) | 2.11931994 |
| 57 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 2.08658941 |
| 58 | Vaginal atresia (HP:0000148) | 2.07701586 |
| 59 | Genital tract atresia (HP:0001827) | 2.07030813 |
| 60 | Postaxial foot polydactyly (HP:0001830) | 2.06927118 |
| 61 | Abnormality of the labia minora (HP:0012880) | 2.06332832 |
| 62 | Attenuation of retinal blood vessels (HP:0007843) | 2.03410223 |
| 63 | Congenital, generalized hypertrichosis (HP:0004540) | 2.03135809 |
| 64 | Increased intramyocellular lipid droplets (HP:0012240) | 2.03063731 |
| 65 | Sclerocornea (HP:0000647) | 1.99086830 |
| 66 | Short tibia (HP:0005736) | 1.98523231 |
| 67 | Pendular nystagmus (HP:0012043) | 1.98307725 |
| 68 | Abnormality of B cell number (HP:0010975) | 1.98184860 |
| 69 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.97129170 |
| 70 | Hyperglycinuria (HP:0003108) | 1.96404776 |
| 71 | Postaxial hand polydactyly (HP:0001162) | 1.95637120 |
| 72 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 1.94967242 |
| 73 | Lethargy (HP:0001254) | 1.94631574 |
| 74 | Aplastic anemia (HP:0001915) | 1.93169790 |
| 75 | Dicarboxylic aciduria (HP:0003215) | 1.93017526 |
| 76 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.93017526 |
| 77 | IgG deficiency (HP:0004315) | 1.92915036 |
| 78 | Agitation (HP:0000713) | 1.92573993 |
| 79 | Combined immunodeficiency (HP:0005387) | 1.91483231 |
| 80 | Type 2 muscle fiber atrophy (HP:0003554) | 1.89711288 |
| 81 | Decreased central vision (HP:0007663) | 1.89086983 |
| 82 | Type I transferrin isoform profile (HP:0003642) | 1.88713618 |
| 83 | Thyroiditis (HP:0100646) | 1.87745521 |
| 84 | Supernumerary spleens (HP:0009799) | 1.87464379 |
| 85 | Broad foot (HP:0001769) | 1.85650676 |
| 86 | Leukodystrophy (HP:0002415) | 1.82575008 |
| 87 | Retinal dysplasia (HP:0007973) | 1.80912023 |
| 88 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 1.80889288 |
| 89 | Intestinal atresia (HP:0011100) | 1.80494083 |
| 90 | Type II lissencephaly (HP:0007260) | 1.79551531 |
| 91 | Delayed CNS myelination (HP:0002188) | 1.79095453 |
| 92 | Poor coordination (HP:0002370) | 1.78602545 |
| 93 | Increased serum pyruvate (HP:0003542) | 1.78402766 |
| 94 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 1.78032269 |
| 95 | CNS demyelination (HP:0007305) | 1.77578874 |
| 96 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 1.76284717 |
| 97 | Lissencephaly (HP:0001339) | 1.76144674 |
| 98 | Abnormality of secondary sexual hair (HP:0009888) | 1.75043693 |
| 99 | Abnormality of the axillary hair (HP:0100134) | 1.75043693 |
| 100 | Abnormal glycosylation (HP:0012345) | 1.74862043 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BCR | 3.74418529 |
| 2 | KDR | 3.65388869 |
| 3 | MAP4K2 | 3.53802950 |
| 4 | SRPK1 | 3.05284014 |
| 5 | MAP2K7 | 3.04675028 |
| 6 | WNK3 | 2.69870480 |
| 7 | TRIM28 | 2.56033288 |
| 8 | BCKDK | 2.49283399 |
| 9 | ERBB3 | 2.33727699 |
| 10 | MAP3K4 | 2.29959185 |
| 11 | TESK2 | 2.24747349 |
| 12 | ZAK | 2.05853670 |
| 13 | VRK2 | 2.00420042 |
| 14 | CSNK1G3 | 1.97496149 |
| 15 | MAPK13 | 1.84135229 |
| 16 | RPS6KA4 | 1.79713202 |
| 17 | PINK1 | 1.77325466 |
| 18 | CSNK1A1L | 1.76235049 |
| 19 | BUB1 | 1.75587874 |
| 20 | CSNK1G2 | 1.70475915 |
| 21 | STK16 | 1.67358332 |
| 22 | EPHA3 | 1.64405659 |
| 23 | CSNK1G1 | 1.61217026 |
| 24 | LIMK1 | 1.56667603 |
| 25 | TESK1 | 1.56568989 |
| 26 | VRK1 | 1.53797496 |
| 27 | EPHA4 | 1.32875884 |
| 28 | ADRBK2 | 1.30624678 |
| 29 | PLK2 | 1.29049421 |
| 30 | CAMKK2 | 1.22771308 |
| 31 | PLK4 | 1.16577395 |
| 32 | GRK1 | 1.13732978 |
| 33 | TXK | 1.07497973 |
| 34 | TIE1 | 1.06973175 |
| 35 | UHMK1 | 1.06550974 |
| 36 | INSRR | 1.05149670 |
| 37 | CDC7 | 0.98082508 |
| 38 | FRK | 0.95596032 |
| 39 | EIF2AK3 | 0.94859934 |
| 40 | PIM2 | 0.93544505 |
| 41 | CCNB1 | 0.92647912 |
| 42 | RPS6KA5 | 0.91479438 |
| 43 | MUSK | 0.90258370 |
| 44 | MAP3K5 | 0.89557159 |
| 45 | DYRK2 | 0.89153055 |
| 46 | MKNK1 | 0.88535437 |
| 47 | TLK1 | 0.87265605 |
| 48 | ITK | 0.84918855 |
| 49 | NUAK1 | 0.80190144 |
| 50 | PASK | 0.80152699 |
| 51 | TNK2 | 0.79615998 |
| 52 | PLK1 | 0.75126462 |
| 53 | BRSK2 | 0.74783074 |
| 54 | TAOK1 | 0.66199792 |
| 55 | CASK | 0.65658757 |
| 56 | BMPR1B | 0.64013418 |
| 57 | PLK3 | 0.62815891 |
| 58 | PRKD3 | 0.62656391 |
| 59 | NME1 | 0.61794437 |
| 60 | PRKCE | 0.59445791 |
| 61 | SIK3 | 0.59109747 |
| 62 | MINK1 | 0.56566713 |
| 63 | CDK14 | 0.55299991 |
| 64 | MARK1 | 0.54720133 |
| 65 | PKN1 | 0.54230113 |
| 66 | DYRK1B | 0.54141318 |
| 67 | CAMK2A | 0.51417563 |
| 68 | CSNK2A1 | 0.50748989 |
| 69 | MAP3K12 | 0.49550715 |
| 70 | CSNK1A1 | 0.49110988 |
| 71 | WEE1 | 0.49109349 |
| 72 | CAMKK1 | 0.46486932 |
| 73 | ATR | 0.45554983 |
| 74 | PRKCG | 0.45322517 |
| 75 | PAK4 | 0.45294755 |
| 76 | AURKB | 0.44962564 |
| 77 | MST4 | 0.44563991 |
| 78 | MAP2K4 | 0.44482330 |
| 79 | PAK3 | 0.44377126 |
| 80 | OBSCN | 0.42968937 |
| 81 | TEC | 0.41863799 |
| 82 | AURKA | 0.41704369 |
| 83 | CDK18 | 0.40979239 |
| 84 | CSNK1D | 0.38430458 |
| 85 | PRKACA | 0.37911045 |
| 86 | NEK1 | 0.37295014 |
| 87 | CAMK2B | 0.37049268 |
| 88 | BRSK1 | 0.36797559 |
| 89 | MYLK | 0.35160169 |
| 90 | PRKCQ | 0.34592025 |
| 91 | CDK15 | 0.33173337 |
| 92 | DYRK1A | 0.32906016 |
| 93 | CSNK2A2 | 0.30533679 |
| 94 | SCYL2 | 0.30487745 |
| 95 | EIF2AK1 | 0.29759109 |
| 96 | BTK | 0.29048390 |
| 97 | CAMK2G | 0.29038527 |
| 98 | GRK7 | 0.28726466 |
| 99 | CDK11A | 0.27563864 |
| 100 | PRKCA | 0.25275958 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.71633419 |
| 2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.65597944 |
| 3 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 3.28987636 |
| 4 | Protein export_Homo sapiens_hsa03060 | 3.10524228 |
| 5 | Parkinsons disease_Homo sapiens_hsa05012 | 3.06078651 |
| 6 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 2.46369284 |
| 7 | Propanoate metabolism_Homo sapiens_hsa00640 | 2.44830490 |
| 8 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 2.26369207 |
| 9 | Mismatch repair_Homo sapiens_hsa03430 | 2.20692077 |
| 10 | DNA replication_Homo sapiens_hsa03030 | 2.19949138 |
| 11 | RNA polymerase_Homo sapiens_hsa03020 | 2.15999953 |
| 12 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 2.15790678 |
| 13 | Steroid biosynthesis_Homo sapiens_hsa00100 | 2.12631556 |
| 14 | Huntingtons disease_Homo sapiens_hsa05016 | 2.07194006 |
| 15 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.98817542 |
| 16 | Base excision repair_Homo sapiens_hsa03410 | 1.93182547 |
| 17 | Spliceosome_Homo sapiens_hsa03040 | 1.92623059 |
| 18 | Alzheimers disease_Homo sapiens_hsa05010 | 1.91369168 |
| 19 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.91055993 |
| 20 | Homologous recombination_Homo sapiens_hsa03440 | 1.91026006 |
| 21 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.79890492 |
| 22 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.66843073 |
| 23 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.62365727 |
| 24 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.62220971 |
| 25 | Phototransduction_Homo sapiens_hsa04744 | 1.49973918 |
| 26 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.48980705 |
| 27 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.39730012 |
| 28 | RNA degradation_Homo sapiens_hsa03018 | 1.38590514 |
| 29 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.37479587 |
| 30 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.36355408 |
| 31 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.30787936 |
| 32 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.23610152 |
| 33 | Basal transcription factors_Homo sapiens_hsa03022 | 1.23335826 |
| 34 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.19953239 |
| 35 | Peroxisome_Homo sapiens_hsa04146 | 1.16431370 |
| 36 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.06074520 |
| 37 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.05409698 |
| 38 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.01152630 |
| 39 | RNA transport_Homo sapiens_hsa03013 | 0.97048744 |
| 40 | Nicotine addiction_Homo sapiens_hsa05033 | 0.93866769 |
| 41 | Purine metabolism_Homo sapiens_hsa00230 | 0.92055306 |
| 42 | Retinol metabolism_Homo sapiens_hsa00830 | 0.90093276 |
| 43 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.87534373 |
| 44 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.86403684 |
| 45 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.84870046 |
| 46 | Taste transduction_Homo sapiens_hsa04742 | 0.82713465 |
| 47 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.81873872 |
| 48 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.81002263 |
| 49 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.80061334 |
| 50 | Ribosome_Homo sapiens_hsa03010 | 0.79254313 |
| 51 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.75905519 |
| 52 | Metabolic pathways_Homo sapiens_hsa01100 | 0.73721394 |
| 53 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.73264196 |
| 54 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.72278488 |
| 55 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.71933945 |
| 56 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.70483829 |
| 57 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.70304944 |
| 58 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.70028682 |
| 59 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.68179721 |
| 60 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.63272874 |
| 61 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.61519536 |
| 62 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.60131670 |
| 63 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.59378010 |
| 64 | GABAergic synapse_Homo sapiens_hsa04727 | 0.58611277 |
| 65 | Olfactory transduction_Homo sapiens_hsa04740 | 0.58336104 |
| 66 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.57086091 |
| 67 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.56906248 |
| 68 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.56012556 |
| 69 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.55735710 |
| 70 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.55326720 |
| 71 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.54300145 |
| 72 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.53009694 |
| 73 | Carbon metabolism_Homo sapiens_hsa01200 | 0.52539562 |
| 74 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.52290529 |
| 75 | Shigellosis_Homo sapiens_hsa05131 | 0.50630208 |
| 76 | Cell cycle_Homo sapiens_hsa04110 | 0.50334049 |
| 77 | Morphine addiction_Homo sapiens_hsa05032 | 0.50315781 |
| 78 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.46599518 |
| 79 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.45318875 |
| 80 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.44438050 |
| 81 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.44196065 |
| 82 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.44096207 |
| 83 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.41874633 |
| 84 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.40967042 |
| 85 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.38810468 |
| 86 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.38101073 |
| 87 | Alcoholism_Homo sapiens_hsa05034 | 0.37201076 |
| 88 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.33763860 |
| 89 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.31009994 |
| 90 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.30027951 |
| 91 | Sulfur relay system_Homo sapiens_hsa04122 | 0.28647365 |
| 92 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.27797284 |
| 93 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.27626991 |
| 94 | Salmonella infection_Homo sapiens_hsa05132 | 0.26381351 |
| 95 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.25499204 |
| 96 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.24061213 |
| 97 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.22981200 |
| 98 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.20956939 |
| 99 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.20823577 |
| 100 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.20472913 |

