SNRPEP6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial respiratory chain complex I biogenesis (GO:0097031)7.94103868
2mitochondrial respiratory chain complex I assembly (GO:0032981)7.94103868
3NADH dehydrogenase complex assembly (GO:0010257)7.94103868
4mitochondrial calcium ion transport (GO:0006851)7.91436417
5positive regulation of mitochondrial calcium ion concentration (GO:0051561)7.11921954
6protein complex biogenesis (GO:0070271)6.34293655
7mitochondrial respiratory chain complex assembly (GO:0033108)6.07577058
8cellular protein complex localization (GO:0034629)5.89847404
9mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.76762383
10energy coupled proton transport, down electrochemical gradient (GO:0015985)5.60276462
11ATP synthesis coupled proton transport (GO:0015986)5.60276462
12viral transcription (GO:0019083)5.59456085
13translational termination (GO:0006415)5.36157240
14neuron fate determination (GO:0048664)5.16100206
15ribosomal small subunit assembly (GO:0000028)5.10735924
16maturation of SSU-rRNA (GO:0030490)4.81007323
17microtubule depolymerization (GO:0007019)4.76375766
18SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.66601093
19cotranslational protein targeting to membrane (GO:0006613)4.65347722
20vitamin transmembrane transport (GO:0035461)4.64298015
21protein targeting to ER (GO:0045047)4.58481918
22hematopoietic stem cell proliferation (GO:0071425)4.56295556
23behavioral response to nicotine (GO:0035095)4.48795537
24sequestering of actin monomers (GO:0042989)4.45113508
25translational elongation (GO:0006414)4.43776288
26ribosomal small subunit biogenesis (GO:0042274)4.41602824
27establishment of protein localization to endoplasmic reticulum (GO:0072599)4.40729224
28cellular protein complex disassembly (GO:0043624)4.31860055
29mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.30797619
30protein localization to endoplasmic reticulum (GO:0070972)4.29949101
31protein localization to cilium (GO:0061512)4.29561173
32sulfur amino acid catabolic process (GO:0000098)4.28731428
33mitochondrial calcium ion homeostasis (GO:0051560)4.13781197
34nonmotile primary cilium assembly (GO:0035058)4.08591906
35respiratory electron transport chain (GO:0022904)3.97943515
36viral life cycle (GO:0019058)3.91607194
37electron transport chain (GO:0022900)3.91476859
38nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.91208457
39protein complex localization (GO:0031503)3.89600419
40pyrimidine-containing compound transmembrane transport (GO:0072531)3.88483022
41mitotic sister chromatid segregation (GO:0000070)3.78848558
42GTP biosynthetic process (GO:0006183)3.72307501
43axonemal dynein complex assembly (GO:0070286)3.72162619
44protein complex disassembly (GO:0043241)3.71866751
45cysteine metabolic process (GO:0006534)3.70380870
46regulation of autophagic vacuole assembly (GO:2000785)3.54572163
47establishment of protein localization to mitochondrial membrane (GO:0090151)3.49568682
48macromolecular complex disassembly (GO:0032984)3.41896596
49chaperone-mediated protein transport (GO:0072321)3.41119024
50kinetochore assembly (GO:0051382)3.39964150
51translational initiation (GO:0006413)3.37681298
52purine nucleoside triphosphate biosynthetic process (GO:0009145)3.37050628
53purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.33881275
54chromatin remodeling at centromere (GO:0031055)3.32454935
55epithelial cilium movement (GO:0003351)3.26549592
56ATP biosynthetic process (GO:0006754)3.21746677
57cilium movement (GO:0003341)3.21144095
58nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.19382864
59epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.19067409
60UTP biosynthetic process (GO:0006228)3.17600831
61exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.16052272
62sister chromatid segregation (GO:0000819)3.11628422
63telomere maintenance via semi-conservative replication (GO:0032201)3.10547298
64CENP-A containing nucleosome assembly (GO:0034080)3.08277965
65nuclear-transcribed mRNA catabolic process (GO:0000956)3.07260583
66cellular component biogenesis (GO:0044085)3.06115052
67DNA strand elongation involved in DNA replication (GO:0006271)3.05904200
68hydrogen ion transmembrane transport (GO:1902600)3.05707018
69DNA strand elongation (GO:0022616)3.03916800
70protein targeting to membrane (GO:0006612)3.03615595
71kinetochore organization (GO:0051383)3.03400414
72mRNA catabolic process (GO:0006402)2.97709231
73midbrain development (GO:0030901)2.93873333
74platelet dense granule organization (GO:0060155)2.92071430
75regulation of vacuole organization (GO:0044088)2.84429214
76UTP metabolic process (GO:0046051)2.83004723
77microtubule polymerization or depolymerization (GO:0031109)2.80104122
78ribonucleoside triphosphate biosynthetic process (GO:0009201)2.79540965
79translation (GO:0006412)2.79171248
80alternative mRNA splicing, via spliceosome (GO:0000380)2.74482557
81intraciliary transport (GO:0042073)2.74087662
82nucleoside diphosphate phosphorylation (GO:0006165)2.69406229
83proton transport (GO:0015992)2.68717332
84homocysteine metabolic process (GO:0050667)2.66722161
85serine family amino acid biosynthetic process (GO:0009070)2.65993469
86telomere maintenance via recombination (GO:0000722)2.63690996
87RNA catabolic process (GO:0006401)2.63435387
88hydrogen transport (GO:0006818)2.61808174
89termination of RNA polymerase III transcription (GO:0006386)2.59063220
90transcription elongation from RNA polymerase III promoter (GO:0006385)2.59063220
91attachment of spindle microtubules to kinetochore (GO:0008608)2.57720153
92nucleoside triphosphate biosynthetic process (GO:0009142)2.57614902
93L-fucose catabolic process (GO:0042355)2.57230998
94fucose catabolic process (GO:0019317)2.57230998
95L-fucose metabolic process (GO:0042354)2.57230998
96DNA damage response, detection of DNA damage (GO:0042769)2.56912137
97positive regulation of embryonic development (GO:0040019)2.54013472
98positive regulation of gastrulation (GO:2000543)2.52683145
99mitochondrial transport (GO:0006839)2.50975263
100DNA integration (GO:0015074)2.50966079

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.87861220
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.88016246
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.07579397
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.65033794
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.24576073
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.11681667
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.00086736
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.90870718
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.87305568
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.79463435
11TP63_19390658_ChIP-ChIP_HaCaT_Human2.75942378
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.31566110
13E2F7_22180533_ChIP-Seq_HELA_Human2.26455420
14TTF2_22483619_ChIP-Seq_HELA_Human2.21632164
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.17489411
16EWS_26573619_Chip-Seq_HEK293_Human2.14577847
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.13724171
18ELK1_19687146_ChIP-ChIP_HELA_Human2.11919651
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.10656874
20VDR_22108803_ChIP-Seq_LS180_Human2.04203553
21CBX2_27304074_Chip-Seq_ESCs_Mouse2.02615768
22MYC_18940864_ChIP-ChIP_HL60_Human2.01982110
23MYC_18555785_ChIP-Seq_MESCs_Mouse2.01020746
24EZH2_22144423_ChIP-Seq_EOC_Human2.00902463
25ETS1_20019798_ChIP-Seq_JURKAT_Human2.00463317
26FOXP3_21729870_ChIP-Seq_TREG_Human1.96845375
27FUS_26573619_Chip-Seq_HEK293_Human1.95447811
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.94239312
29ZNF274_21170338_ChIP-Seq_K562_Hela1.87051143
30AR_21909140_ChIP-Seq_LNCAP_Human1.80782489
31SOX2_18555785_ChIP-Seq_MESCs_Mouse1.77740658
32XRN2_22483619_ChIP-Seq_HELA_Human1.75666149
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.74972514
34SOX2_16153702_ChIP-ChIP_HESCs_Human1.74413034
35CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.71200598
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68932533
37NOTCH1_21737748_ChIP-Seq_TLL_Human1.67387649
38CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.63424131
39NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.54382859
40POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.47987858
41VDR_23849224_ChIP-Seq_CD4+_Human1.44343080
42CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.44142879
43MYC_18358816_ChIP-ChIP_MESCs_Mouse1.38995714
44TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38194886
45POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.38194886
46NANOG_16153702_ChIP-ChIP_HESCs_Human1.37601337
47POU5F1_16153702_ChIP-ChIP_HESCs_Human1.35865029
48E2F1_21310950_ChIP-Seq_MCF-7_Human1.34748021
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.34731551
50PADI4_21655091_ChIP-ChIP_MCF-7_Human1.32736399
51EZH2_27304074_Chip-Seq_ESCs_Mouse1.30388727
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.23791913
53MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.22089407
54IRF1_19129219_ChIP-ChIP_H3396_Human1.22068243
55KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.20154598
56POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.18274738
57RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.18164094
58IGF1R_20145208_ChIP-Seq_DFB_Human1.17568739
59GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16729136
60TAF15_26573619_Chip-Seq_HEK293_Human1.16330979
61THAP11_20581084_ChIP-Seq_MESCs_Mouse1.16163100
62EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.14863545
63JARID2_20064375_ChIP-Seq_MESCs_Mouse1.13728447
64FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.11988116
65GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09367315
66TP53_22573176_ChIP-Seq_HFKS_Human1.08472680
67PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.07324402
68GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.04531965
69MYC_19030024_ChIP-ChIP_MESCs_Mouse1.03515137
70CTBP1_25329375_ChIP-Seq_LNCAP_Human1.02602877
71CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.00603219
72MYC_19079543_ChIP-ChIP_MESCs_Mouse1.00476313
73SRF_21415370_ChIP-Seq_HL-1_Mouse1.00217674
74RNF2_27304074_Chip-Seq_NSC_Mouse0.99843981
75SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.99389159
76SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.96833704
77GATA6_21074721_ChIP-Seq_CACO-2_Human0.96245268
78HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.95234349
79DCP1A_22483619_ChIP-Seq_HELA_Human0.93428875
80CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.92016972
81ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.91494192
82E2F1_18555785_ChIP-Seq_MESCs_Mouse0.87968442
83EED_16625203_ChIP-ChIP_MESCs_Mouse0.87535619
84E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.87466879
85TP53_20018659_ChIP-ChIP_R1E_Mouse0.86827658
86TAF2_19829295_ChIP-Seq_ESCs_Human0.86675563
87EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.86611397
88NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.84901822
89CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.83421677
90RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.83084026
91HTT_18923047_ChIP-ChIP_STHdh_Human0.82425435
92ETV2_25802403_ChIP-Seq_MESCs_Mouse0.80516271
93CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.80389597
94GABP_19822575_ChIP-Seq_HepG2_Human0.80317972
95NANOG_21062744_ChIP-ChIP_HESCs_Human0.80181276
96FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.80120178
97GATA1_26923725_Chip-Seq_HPCs_Mouse0.79627520
98PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.79457788
99SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.78548568
100KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.77473175

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.18737724
2MP0010030_abnormal_orbit_morphology5.75788542
3MP0006292_abnormal_olfactory_placode3.66391535
4MP0000566_synostosis3.34307123
5MP0002938_white_spotting3.25908591
6MP0003136_yellow_coat_color3.19557516
7MP0002653_abnormal_ependyma_morphology3.10815763
8MP0001293_anophthalmia2.89360937
9MP0004142_abnormal_muscle_tone2.74556252
10MP0001346_abnormal_lacrimal_gland2.45018309
11MP0001529_abnormal_vocalization2.44054859
12MP0002009_preneoplasia2.38819709
13MP0002234_abnormal_pharynx_morphology2.32264971
14MP0000049_abnormal_middle_ear2.31286395
15MP0003283_abnormal_digestive_organ2.21936893
16MP0002249_abnormal_larynx_morphology2.14822419
17MP0000372_irregular_coat_pigmentation2.10478090
18MP0008789_abnormal_olfactory_epithelium2.02812135
19MP0003693_abnormal_embryo_hatching1.86388064
20MP0003937_abnormal_limbs/digits/tail_de1.77491243
21MP0005174_abnormal_tail_pigmentation1.59651973
22MP0005645_abnormal_hypothalamus_physiol1.57135055
23MP0002697_abnormal_eye_size1.55815379
24MP0004742_abnormal_vestibular_system1.44062958
25MP0001485_abnormal_pinna_reflex1.41385392
26MP0005377_hearing/vestibular/ear_phenot1.38974434
27MP0003878_abnormal_ear_physiology1.38974434
28MP0005394_taste/olfaction_phenotype1.37850707
29MP0005499_abnormal_olfactory_system1.37850707
30MP0009053_abnormal_anal_canal1.37707833
31MP0003806_abnormal_nucleotide_metabolis1.33421931
32MP0002233_abnormal_nose_morphology1.32902526
33MP0006035_abnormal_mitochondrial_morpho1.31948668
34MP0006276_abnormal_autonomic_nervous1.30544573
35MP0005551_abnormal_eye_electrophysiolog1.28429900
36MP0001764_abnormal_homeostasis1.26491097
37MP0002102_abnormal_ear_morphology1.24985577
38MP0003880_abnormal_central_pattern1.24870343
39MP0003938_abnormal_ear_development1.24275930
40MP0000026_abnormal_inner_ear1.24135254
41MP0001286_abnormal_eye_development1.24096554
42MP0002822_catalepsy1.23961639
43MP0005253_abnormal_eye_physiology1.18941206
44MP0005391_vision/eye_phenotype1.14204738
45MP0003718_maternal_effect1.13348731
46MP0003942_abnormal_urinary_system1.12452666
47MP0004885_abnormal_endolymph1.12343330
48MP0004133_heterotaxia1.12117238
49MP0009250_abnormal_appendicular_skeleto1.11266385
50MP0002277_abnormal_respiratory_mucosa1.11008105
51MP0003755_abnormal_palate_morphology1.09213023
52MP0004043_abnormal_pH_regulation1.08399981
53MP0002095_abnormal_skin_pigmentation1.05584533
54MP0008875_abnormal_xenobiotic_pharmacok1.04217641
55MP0000631_abnormal_neuroendocrine_gland1.01654689
56MP0005248_abnormal_Harderian_gland1.01568865
57MP0009046_muscle_twitch1.00804299
58MP0005409_darkened_coat_color0.98349072
59MP0005408_hypopigmentation0.97662067
60MP0001873_stomach_inflammation0.96406436
61MP0005195_abnormal_posterior_eye0.94744804
62MP0000778_abnormal_nervous_system0.94026341
63MP0003315_abnormal_perineum_morphology0.93677716
64MP0001905_abnormal_dopamine_level0.93443666
65MP0008877_abnormal_DNA_methylation0.92120918
66MP0003567_abnormal_fetal_cardiomyocyte0.91507982
67MP0001348_abnormal_lacrimal_gland0.89434193
68MP0000647_abnormal_sebaceous_gland0.88221905
69MP0002092_abnormal_eye_morphology0.85160844
70MP0003959_abnormal_lean_body0.84882033
71MP0002736_abnormal_nociception_after0.82321348
72MP0001324_abnormal_eye_pigmentation0.81211141
73MP0002909_abnormal_adrenal_gland0.78093212
74MP0003011_delayed_dark_adaptation0.77153314
75MP0002752_abnormal_somatic_nervous0.76702534
76MP0002282_abnormal_trachea_morphology0.73616508
77MP0001340_abnormal_eyelid_morphology0.72685007
78MP0003111_abnormal_nucleus_morphology0.71834787
79MP0005646_abnormal_pituitary_gland0.71040772
80MP0009745_abnormal_behavioral_response0.69818891
81MP0004145_abnormal_muscle_electrophysio0.68708003
82MP0003861_abnormal_nervous_system0.68686674
83MP0002210_abnormal_sex_determination0.66994897
84MP0002876_abnormal_thyroid_physiology0.66683258
85MP0003119_abnormal_digestive_system0.66523893
86MP0008872_abnormal_physiological_respon0.64839762
87MP0002109_abnormal_limb_morphology0.63017520
88MP0005187_abnormal_penis_morphology0.63013768
89MP0001727_abnormal_embryo_implantation0.61596362
90MP0001663_abnormal_digestive_system0.61459449
91MP0002116_abnormal_craniofacial_bone0.61222549
92MP0003890_abnormal_embryonic-extraembry0.61093417
93MP0001186_pigmentation_phenotype0.60545263
94MP0002075_abnormal_coat/hair_pigmentati0.60304198
95MP0002111_abnormal_tail_morphology0.58855332
96MP0003122_maternal_imprinting0.58237463
97MP0010094_abnormal_chromosome_stability0.57907485
98MP0001929_abnormal_gametogenesis0.55451269
99MP0002572_abnormal_emotion/affect_behav0.54462907
100MP0003698_abnormal_male_reproductive0.53800661

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the sacrum (HP:0008517)4.67265335
2Hypoplasia of the pons (HP:0012110)4.48203298
3Abnormality of the pons (HP:0007361)4.16732765
4Missing ribs (HP:0000921)3.91507119
5Pheochromocytoma (HP:0002666)3.81334123
611 pairs of ribs (HP:0000878)3.78350759
7Concave nail (HP:0001598)3.68394358
8Abnormality of alanine metabolism (HP:0010916)3.65253480
9Hyperalaninemia (HP:0003348)3.65253480
10Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.65253480
11Pancreatic cysts (HP:0001737)3.58381952
12Mesomelia (HP:0003027)3.51335125
13Rib fusion (HP:0000902)3.50417301
14Abnormal ciliary motility (HP:0012262)3.48018976
15Abnormal number of erythroid precursors (HP:0012131)3.29746187
16Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.28348531
17Short 4th metacarpal (HP:0010044)3.28348531
18Abnormality of the 4th metacarpal (HP:0010012)3.25922457
19Abnormality of cells of the erythroid lineage (HP:0012130)3.25084995
20Acute encephalopathy (HP:0006846)3.22000405
21Septo-optic dysplasia (HP:0100842)3.19779002
22Neuroendocrine neoplasm (HP:0100634)3.14565068
23Abnormality of midbrain morphology (HP:0002418)3.12505060
24Molar tooth sign on MRI (HP:0002419)3.12505060
25Anophthalmia (HP:0000528)3.10171584
26Confusion (HP:0001289)3.02549554
27Abnormal respiratory motile cilium physiology (HP:0012261)3.02535601
28Chorioretinal atrophy (HP:0000533)3.01596239
29Short middle phalanx of the 5th finger (HP:0004220)2.94726919
30Sclerocornea (HP:0000647)2.88203575
31Acute necrotizing encephalopathy (HP:0006965)2.85446386
32Macrocytic anemia (HP:0001972)2.81982730
33Mitochondrial inheritance (HP:0001427)2.78700088
34Cutaneous finger syndactyly (HP:0010554)2.70765087
35Reticulocytopenia (HP:0001896)2.61898569
36Pancreatic fibrosis (HP:0100732)2.60789569
37Morphological abnormality of the pyramidal tract (HP:0002062)2.58696329
38Pancreatic islet-cell hyperplasia (HP:0004510)2.58117897
39Abnormal mitochondria in muscle tissue (HP:0008316)2.49696302
40Medial flaring of the eyebrow (HP:0010747)2.45253684
413-Methylglutaconic aciduria (HP:0003535)2.38874505
42Congenital, generalized hypertrichosis (HP:0004540)2.38594725
43Type I transferrin isoform profile (HP:0003642)2.33626775
44Maternal diabetes (HP:0009800)2.32702723
45True hermaphroditism (HP:0010459)2.32509075
46Bifid tongue (HP:0010297)2.31241203
47Hepatocellular necrosis (HP:0001404)2.29187098
48Congenital stationary night blindness (HP:0007642)2.29096199
49Type II lissencephaly (HP:0007260)2.26130130
50Increased CSF lactate (HP:0002490)2.22655002
51Pendular nystagmus (HP:0012043)2.21624492
52Poor coordination (HP:0002370)2.20571949
53Vaginal atresia (HP:0000148)2.16981762
54High anterior hairline (HP:0009890)2.15060054
55Mutism (HP:0002300)2.14251286
56Abnormality of the parietal bone (HP:0002696)2.14028669
57Abnormality of abdominal situs (HP:0011620)2.13487780
58Abdominal situs inversus (HP:0003363)2.13487780
59Cutaneous syndactyly (HP:0012725)2.12315094
60Progressive macrocephaly (HP:0004481)2.11622522
61Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.10995907
62Congenital primary aphakia (HP:0007707)2.10219021
63Nephronophthisis (HP:0000090)2.07665781
64Optic disc pallor (HP:0000543)2.07533970
65Symphalangism affecting the phalanges of the hand (HP:0009773)2.06985060
66Gait imbalance (HP:0002141)2.06872992
67Abnormality of the phalanges of the 5th finger (HP:0004213)2.06852363
68Anencephaly (HP:0002323)2.06539288
69Genital tract atresia (HP:0001827)2.02018021
70Brushfield spots (HP:0001088)1.99054443
71Abnormal lung lobation (HP:0002101)1.97418358
72Hepatic necrosis (HP:0002605)1.95802684
73Absent septum pellucidum (HP:0001331)1.95640296
74Cerebral edema (HP:0002181)1.95573183
75Focal motor seizures (HP:0011153)1.91152312
76Hyperinsulinemic hypoglycemia (HP:0000825)1.91003249
77Retinal dysplasia (HP:0007973)1.90465427
78Chronic hepatic failure (HP:0100626)1.88562854
79Bilateral microphthalmos (HP:0007633)1.88428067
80Partial duplication of the phalanx of hand (HP:0009999)1.86348644
81Paraparesis (HP:0002385)1.86307022
82Nephrogenic diabetes insipidus (HP:0009806)1.84940997
83Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.83983244
84Birth length less than 3rd percentile (HP:0003561)1.83864833
85Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.83676760
86Hyperglycinemia (HP:0002154)1.82277624
87Abnormality of the diencephalon (HP:0010662)1.81959790
88Multicystic kidney dysplasia (HP:0000003)1.80919454
89Abolished electroretinogram (ERG) (HP:0000550)1.80196129
90Abnormal respiratory motile cilium morphology (HP:0005938)1.79753035
91Abnormal respiratory epithelium morphology (HP:0012253)1.79753035
92Partial agenesis of the corpus callosum (HP:0001338)1.79504515
93Lipid accumulation in hepatocytes (HP:0006561)1.77781953
94Lactic acidosis (HP:0003128)1.77641996
95Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.76573039
96Decreased activity of mitochondrial respiratory chain (HP:0008972)1.76573039
97Occipital encephalocele (HP:0002085)1.76391894
98Lissencephaly (HP:0001339)1.76088103
99Abnormal protein N-linked glycosylation (HP:0012347)1.74098876
100Abnormal glycosylation (HP:0012345)1.74098876

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK27.99509780
2BUB13.68086016
3WEE13.57387319
4VRK13.33181929
5INSRR3.24940666
6TAF12.75502598
7BLK2.68569532
8NEK22.44882972
9NME12.23768731
10EPHB22.20707968
11STK32.17246896
12EIF2AK31.99372785
13YES11.89864991
14CCNB11.85982604
15TLK11.81887481
16BRSK21.81525356
17BCKDK1.62301391
18CHEK21.57764177
19KIT1.39007423
20STK161.38955078
21MAP2K71.38007202
22MAP3K121.36941057
23EIF2AK21.28076870
24TYRO31.23340601
25MAPKAPK51.15633990
26MAP3K41.15468660
27PNCK1.14171164
28PLK41.13296538
29MAP3K91.13094204
30ZAK1.11466611
31CDC71.09627682
32GRK11.09435248
33NUAK11.08067859
34MAPKAPK31.05982326
35PDGFRB1.05619696
36CLK11.04343384
37CAMK11.02480783
38ADRBK20.99217619
39SYK0.97915316
40BMPR1B0.97043150
41WNK30.95934111
42EPHA40.91794390
43DYRK20.91386961
44CAMK40.89812612
45MAP2K40.89322530
46PIM10.85955284
47PLK30.84537653
48RPS6KA60.82977188
49UHMK10.82366320
50WNK40.82163914
51RPS6KA50.75286193
52PLK10.71776787
53TAOK20.69449319
54BRSK10.68472665
55ATR0.65719749
56DYRK1B0.65060099
57TAOK30.64727349
58STK240.59727597
59RPS6KL10.57125469
60RPS6KC10.57125469
61LRRK20.57065350
62SIK10.56227955
63PRKCG0.54541809
64CDK70.53213119
65MAP3K110.48614943
66AURKA0.48114437
67MOS0.47774713
68CASK0.47013268
69CDK30.45736377
70MAP3K80.45559269
71CSNK2A10.45046139
72MKNK10.43434346
73CSNK1A10.40831984
74MAPK150.40720218
75AURKB0.40490716
76FES0.39018473
77ERBB30.38805954
78PRKCH0.38449652
79MAP3K100.37504848
80FRK0.35534970
81PRKCZ0.35481790
82PINK10.35057155
83DYRK30.35050033
84HIPK20.32678959
85CSNK2A20.32387006
86MAP4K20.30393800
87TXK0.30310743
88TNIK0.28676983
89DAPK30.22993418
90TTK0.22163780
91INSR0.21623366
92TRPM70.21040269
93NTRK20.20689224
94MAPK70.20040535
95PTK2B0.19228831
96MAP3K70.18726777
97CDK10.18611512
98NTRK30.16896832
99CAMK2A0.16579897
100ERN10.16542472

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.90430448
2Oxidative phosphorylation_Homo sapiens_hsa001904.16368149
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.70764938
4Parkinsons disease_Homo sapiens_hsa050123.47002935
5Homologous recombination_Homo sapiens_hsa034403.07151138
6DNA replication_Homo sapiens_hsa030302.82960109
7Huntingtons disease_Homo sapiens_hsa050162.78069396
8Proteasome_Homo sapiens_hsa030502.54225890
9RNA polymerase_Homo sapiens_hsa030202.46030062
10Mismatch repair_Homo sapiens_hsa034302.41480468
11Alzheimers disease_Homo sapiens_hsa050102.40323611
12Vitamin digestion and absorption_Homo sapiens_hsa049772.30573863
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.24569382
14RNA degradation_Homo sapiens_hsa030182.21738861
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.21445945
16Nucleotide excision repair_Homo sapiens_hsa034202.15783491
17Hedgehog signaling pathway_Homo sapiens_hsa043402.10044045
18Cardiac muscle contraction_Homo sapiens_hsa042602.04622561
19Basal cell carcinoma_Homo sapiens_hsa052171.97923417
20Protein export_Homo sapiens_hsa030601.91564969
21One carbon pool by folate_Homo sapiens_hsa006701.81551161
22Fanconi anemia pathway_Homo sapiens_hsa034601.74413353
23Sulfur relay system_Homo sapiens_hsa041221.70997415
24Pyrimidine metabolism_Homo sapiens_hsa002401.61543967
25Phototransduction_Homo sapiens_hsa047441.51708081
26Folate biosynthesis_Homo sapiens_hsa007901.51263509
27Basal transcription factors_Homo sapiens_hsa030221.36143469
28Spliceosome_Homo sapiens_hsa030401.31036909
29Systemic lupus erythematosus_Homo sapiens_hsa053221.29595043
30Base excision repair_Homo sapiens_hsa034101.23382482
31Purine metabolism_Homo sapiens_hsa002301.18086837
32Linoleic acid metabolism_Homo sapiens_hsa005911.09619649
33p53 signaling pathway_Homo sapiens_hsa041151.05447587
34Caffeine metabolism_Homo sapiens_hsa002321.00933324
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.99274412
36Nitrogen metabolism_Homo sapiens_hsa009100.98286838
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.98015108
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.97794515
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.96994387
40Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.95923611
41Nicotine addiction_Homo sapiens_hsa050330.87654135
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.86361989
43Selenocompound metabolism_Homo sapiens_hsa004500.85742390
44Chemical carcinogenesis_Homo sapiens_hsa052040.85503637
45Alcoholism_Homo sapiens_hsa050340.84856824
46Cysteine and methionine metabolism_Homo sapiens_hsa002700.82810396
47Sulfur metabolism_Homo sapiens_hsa009200.82486636
48Maturity onset diabetes of the young_Homo sapiens_hsa049500.80996794
49Steroid hormone biosynthesis_Homo sapiens_hsa001400.79795473
50Cell cycle_Homo sapiens_hsa041100.79758593
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.77210433
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.74756413
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74631126
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.73413656
55Hippo signaling pathway_Homo sapiens_hsa043900.72106390
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.67243434
57Protein digestion and absorption_Homo sapiens_hsa049740.67042592
58Peroxisome_Homo sapiens_hsa041460.64493292
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63493815
60Metabolic pathways_Homo sapiens_hsa011000.63372081
61Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.63280463
62RNA transport_Homo sapiens_hsa030130.57879953
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.57108949
64Wnt signaling pathway_Homo sapiens_hsa043100.52847386
65Retinol metabolism_Homo sapiens_hsa008300.52167992
66Melanogenesis_Homo sapiens_hsa049160.50571486
67Taste transduction_Homo sapiens_hsa047420.46997768
68Propanoate metabolism_Homo sapiens_hsa006400.44072998
69Fat digestion and absorption_Homo sapiens_hsa049750.44013118
70Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.42013657
71Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41425852
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40049993
73Tryptophan metabolism_Homo sapiens_hsa003800.37653238
74Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.37186276
75Glutathione metabolism_Homo sapiens_hsa004800.35332544
76Butanoate metabolism_Homo sapiens_hsa006500.33780064
77Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.32498625
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31852669
79Intestinal immune network for IgA production_Homo sapiens_hsa046720.27308224
80Arachidonic acid metabolism_Homo sapiens_hsa005900.24506692
81Glycerolipid metabolism_Homo sapiens_hsa005610.23480186
82Serotonergic synapse_Homo sapiens_hsa047260.23236179
83Primary immunodeficiency_Homo sapiens_hsa053400.22834426
84Vitamin B6 metabolism_Homo sapiens_hsa007500.21801233
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.19616271
86Pyruvate metabolism_Homo sapiens_hsa006200.18760991
87Ether lipid metabolism_Homo sapiens_hsa005650.17886979
88Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.17697191
89Mineral absorption_Homo sapiens_hsa049780.16581941
90Axon guidance_Homo sapiens_hsa043600.16453030
91Olfactory transduction_Homo sapiens_hsa047400.12424108
92Lysine degradation_Homo sapiens_hsa003100.10867656
93HTLV-I infection_Homo sapiens_hsa051660.10420040
94Epstein-Barr virus infection_Homo sapiens_hsa051690.09681815
95TGF-beta signaling pathway_Homo sapiens_hsa043500.09476777
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.09126632
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.08953851
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.06808846
99Cocaine addiction_Homo sapiens_hsa050300.06586227
100Steroid biosynthesis_Homo sapiens_hsa001000.05899982

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