ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.63296558
2	ATP synthesis coupled proton transport (GO:0015986)	5.63296558
3	phenol-containing compound catabolic process (GO:0019336)	5.56615312
4	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.41612328
5	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.93693014
6	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	4.92324028
7	DNA deamination (GO:0045006)	4.91325626
8	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	4.82468797
9	oxidative phosphorylation (GO:0006119)	4.75145535
10	maturation of SSU-rRNA (GO:0030490)	4.65806728
11	viral transcription (GO:0019083)	4.63408936
12	protein complex biogenesis (GO:0070271)	4.60493693
13	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	4.59956398
14	respiratory electron transport chain (GO:0022904)	4.56844559
15	electron transport chain (GO:0022900)	4.49064038
16	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	4.48643252
17	translational termination (GO:0006415)	4.45048353
18	hormone catabolic process (GO:0042447)	4.37773441
19	platelet dense granule organization (GO:0060155)	4.34826991
20	mitochondrial respiratory chain complex assembly (GO:0033108)	4.29152650
21	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.21136970
22	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.21136970
23	NADH dehydrogenase complex assembly (GO:0010257)	4.21136970
24	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	4.18473367
25	ribosomal large subunit biogenesis (GO:0042273)	4.05773601
26	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.03869696
27	translational elongation (GO:0006414)	4.01675510
28	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.90545718
29	protein neddylation (GO:0045116)	3.87227995
30	aldehyde catabolic process (GO:0046185)	3.85830088
31	cotranslational protein targeting to membrane (GO:0006613)	3.79355137
32	ribosomal small subunit assembly (GO:0000028)	3.78187165
33	protein targeting to ER (GO:0045047)	3.78125286
34	telomere maintenance via semi-conservative replication (GO:0032201)	3.77855701
35	organelle disassembly (GO:1903008)	3.74664834
36	protein localization to endoplasmic reticulum (GO:0070972)	3.67789575
37	ribosomal small subunit biogenesis (GO:0042274)	3.62587964
38	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.60348403
39	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	3.57826732
40	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.55314025
41	chromatin remodeling at centromere (GO:0031055)	3.47138390
42	nucleotide-excision repair, DNA gap filling (GO:0006297)	3.42726582
43	thyroid hormone generation (GO:0006590)	3.40103719
44	intraciliary transport (GO:0042073)	3.39135552
45	tongue development (GO:0043586)	3.33841210
46	viral life cycle (GO:0019058)	3.33407108
47	mannosylation (GO:0097502)	3.32685144
48	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.31333496
49	cornea development in camera-type eye (GO:0061303)	3.28624806
50	purine deoxyribonucleotide catabolic process (GO:0009155)	3.23702060
51	cellular protein complex disassembly (GO:0043624)	3.21542147
52	negative regulation of multicellular organism growth (GO:0040015)	3.19032074
53	peristalsis (GO:0030432)	3.18374399
54	CENP-A containing nucleosome assembly (GO:0034080)	3.18111624
55	ATP biosynthetic process (GO:0006754)	3.17637743
56	translesion synthesis (GO:0019985)	3.16694687
57	DNA strand elongation involved in DNA replication (GO:0006271)	3.13424283
58	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.12796959
59	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.12796959
60	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.10471840
61	cell fate commitment involved in formation of primary germ layer (GO:0060795)	3.08234767
62	anterograde synaptic vesicle transport (GO:0048490)	3.07295459
63	deoxyribonucleotide catabolic process (GO:0009264)	3.07173216
64	cytidine metabolic process (GO:0046087)	3.05894361
65	cytidine catabolic process (GO:0006216)	3.05894361
66	cytidine deamination (GO:0009972)	3.05894361
67	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.03828518
68	hydrogen ion transmembrane transport (GO:1902600)	3.03826757
69	behavioral response to nicotine (GO:0035095)	3.03328297
70	2-deoxyribonucleotide biosynthetic process (GO:0009265)	2.99650685
71	deoxyribose phosphate biosynthetic process (GO:0046385)	2.99650685
72	thyroid hormone metabolic process (GO:0042403)	2.97563658
73	ribonucleoprotein complex disassembly (GO:0032988)	2.95956180
74	deoxyribose phosphate catabolic process (GO:0046386)	2.95275555
75	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.94758337
76	translation (GO:0006412)	2.90542020
77	adenosine metabolic process (GO:0046085)	2.87870676
78	DNA strand elongation (GO:0022616)	2.87501575
79	GPI anchor biosynthetic process (GO:0006506)	2.87047602
80	proton transport (GO:0015992)	2.85176245
81	cullin deneddylation (GO:0010388)	2.84460210
82	telomere maintenance via recombination (GO:0000722)	2.80364303
83	pyrimidine nucleotide catabolic process (GO:0006244)	2.78713708
84	positive regulation of T cell apoptotic process (GO:0070234)	2.78628766
85	regulation of cilium movement (GO:0003352)	2.78460975
86	cytochrome complex assembly (GO:0017004)	2.77995436
87	DNA ligation (GO:0006266)	2.77162562
88	hydrogen transport (GO:0006818)	2.76641082
89	GPI anchor metabolic process (GO:0006505)	2.76318373
90	purine deoxyribonucleotide metabolic process (GO:0009151)	2.76179204
91	neuron fate determination (GO:0048664)	2.73723902
92	DNA replication checkpoint (GO:0000076)	2.73475916
93	translational initiation (GO:0006413)	2.71638161
94	deoxyribonucleotide biosynthetic process (GO:0009263)	2.70874946
95	negative regulation of DNA-templated transcription, elongation (GO:0032785)	2.69895078
96	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.69514552
97	cell proliferation in forebrain (GO:0021846)	2.67365351
98	kinetochore assembly (GO:0051382)	2.65823494
99	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class	2.65174753
100	cellular component biogenesis (GO:0044085)	2.64808673

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	5.91977718
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.99434154
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.79320318
4	EZH2_22144423_ChIP-Seq_EOC_Human	3.73571850
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.63313829
6	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.53830043
7	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.99769250
8	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.86873121
9	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.85354714
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.54363370
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.51448692
12	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.44884206
13	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	2.23822052
14	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.11848854
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.09361415
16	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.04164119
17	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.01764997
18	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.95270781
19	VDR_23849224_ChIP-Seq_CD4+_Human	1.94092965
20	IRF1_19129219_ChIP-ChIP_H3396_Human	1.91227833
21	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.86299129
22	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.79044096
23	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.76738950
24	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.73820801
25	EWS_26573619_Chip-Seq_HEK293_Human	1.68837830
26	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.66976392
27	ZNF274_21170338_ChIP-Seq_K562_Hela	1.66801165
28	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.66489039
29	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.63380514
30	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.59334489
31	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.55691387
32	ELK1_19687146_ChIP-ChIP_HELA_Human	1.52268415
33	FOXP3_21729870_ChIP-Seq_TREG_Human	1.50175314
34	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.48882707
35	MYC_18940864_ChIP-ChIP_HL60_Human	1.45449439
36	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.43321990
37	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.43101693
38	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.41380104
39	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.38095119
40	AR_20517297_ChIP-Seq_VCAP_Human	1.36206391
41	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.35695716
42	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.34625325
43	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.33943720
44	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.33863915
45	FUS_26573619_Chip-Seq_HEK293_Human	1.33782458
46	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.31327026
47	ERG_20517297_ChIP-Seq_VCAP_Human	1.30301241
48	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.28872448
49	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.25402936
50	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.25168162
51	TP53_22573176_ChIP-Seq_HFKS_Human	1.24623786
52	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.24266195
53	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.23561778
54	VDR_22108803_ChIP-Seq_LS180_Human	1.19726895
55	P300_19829295_ChIP-Seq_ESCs_Human	1.19557882
56	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.17383734
57	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.15780563
58	GABP_19822575_ChIP-Seq_HepG2_Human	1.15703294
59	TAF2_19829295_ChIP-Seq_ESCs_Human	1.15147503
60	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.13668624
61	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.12052101
62	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.12052101
63	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.11884293
64	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.11053920
65	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.10890469
66	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.10371144
67	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.10218957
68	NANOG_20526341_ChIP-Seq_ESCs_Human	1.07938124
69	ER_23166858_ChIP-Seq_MCF-7_Human	1.06177428
70	IGF1R_20145208_ChIP-Seq_DFB_Human	1.06088005
71	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.02778036
72	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.00973737
73	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.98873237
74	CIITA_25753668_ChIP-Seq_RAJI_Human	0.98639410
75	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	0.98443873
76	NANOG_19829295_ChIP-Seq_ESCs_Human	0.97785013
77	SOX2_19829295_ChIP-Seq_ESCs_Human	0.97785013
78	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.97603326
79	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.97331682
80	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.96775758
81	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.96092435
82	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.94744458
83	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.94490309
84	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.93956482
85	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.91426174
86	HOXB7_26014856_ChIP-Seq_BT474_Human	0.90014113
87	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.89507448
88	CEBPB_22108803_ChIP-Seq_LS180_Human	0.89035564
89	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.88070922
90	TCF4_22108803_ChIP-Seq_LS180_Human	0.87520662
91	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.86469701
92	TTF2_22483619_ChIP-Seq_HELA_Human	0.86455500
93	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.85419431
94	BCL6_27268052_Chip-Seq_Bcells_Human	0.84831562
95	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.83246123
96	TAF15_26573619_Chip-Seq_HEK293_Human	0.81858721
97	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.81607995
98	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	0.81522653
99	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.80671517
100	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.80272153

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003122_maternal_imprinting	5.12809999
2	MP0009379_abnormal_foot_pigmentation	5.06193211
3	MP0002837_dystrophic_cardiac_calcinosis	3.98260287
4	MP0003121_genomic_imprinting	3.11497894
5	MP0006292_abnormal_olfactory_placode	3.07041972
6	MP0003806_abnormal_nucleotide_metabolis	3.01025628
7	MP0005167_abnormal_blood-brain_barrier	2.83383132
8	MP0008058_abnormal_DNA_repair	2.73185609
9	MP0003646_muscle_fatigue	2.71936315
10	MP0002653_abnormal_ependyma_morphology	2.69947889
11	MP0004147_increased_porphyrin_level	2.67025761
12	MP0009780_abnormal_chondrocyte_physiolo	2.41931013
13	MP0001529_abnormal_vocalization	2.11279446
14	MP0003787_abnormal_imprinting	2.06910814
15	MP0002234_abnormal_pharynx_morphology	2.03229520
16	MP0008789_abnormal_olfactory_epithelium	1.96270000
17	MP0006072_abnormal_retinal_apoptosis	1.93012427
18	MP0005671_abnormal_response_to	1.84578080
19	MP0005646_abnormal_pituitary_gland	1.72353561
20	MP0000372_irregular_coat_pigmentation	1.71899919
21	MP0001968_abnormal_touch/_nociception	1.64024083
22	MP0002736_abnormal_nociception_after	1.60997163
23	MP0004142_abnormal_muscle_tone	1.52487416
24	MP0008872_abnormal_physiological_respon	1.46471262
25	MP0001486_abnormal_startle_reflex	1.45886025
26	MP0008775_abnormal_heart_ventricle	1.45109171
27	MP0000049_abnormal_middle_ear	1.44937057
28	MP0008875_abnormal_xenobiotic_pharmacok	1.44280273
29	MP0003195_calcinosis	1.40846948
30	MP0002138_abnormal_hepatobiliary_system	1.38656864
31	MP0004924_abnormal_behavior	1.33044985
32	MP0005386_behavior/neurological_phenoty	1.33044985
33	MP0001986_abnormal_taste_sensitivity	1.32970002
34	MP0005083_abnormal_biliary_tract	1.31106907
35	MP0005408_hypopigmentation	1.30819016
36	MP0003880_abnormal_central_pattern	1.28618621
37	MP0005499_abnormal_olfactory_system	1.28511123
38	MP0005394_taste/olfaction_phenotype	1.28511123
39	MP0008057_abnormal_DNA_replication	1.28511120
40	MP0005377_hearing/vestibular/ear_phenot	1.26502121
41	MP0003878_abnormal_ear_physiology	1.26502121
42	MP0004133_heterotaxia	1.26102195
43	MP0009053_abnormal_anal_canal	1.21249799
44	MP0002876_abnormal_thyroid_physiology	1.18957456
45	MP0005551_abnormal_eye_electrophysiolog	1.15674842
46	MP0005645_abnormal_hypothalamus_physiol	1.14864524
47	MP0002938_white_spotting	1.14099819
48	MP0003718_maternal_effect	1.12950553
49	MP0010030_abnormal_orbit_morphology	1.10356719
50	MP0010094_abnormal_chromosome_stability	1.10336855
51	MP0001293_anophthalmia	1.07617025
52	MP0009764_decreased_sensitivity_to	1.05771342
53	MP0005253_abnormal_eye_physiology	1.04586168
54	MP0002733_abnormal_thermal_nociception	1.03727486
55	MP0002282_abnormal_trachea_morphology	1.01927497
56	MP0000343_altered_response_to	1.00794675
57	MP0002272_abnormal_nervous_system	1.00710836
58	MP0001346_abnormal_lacrimal_gland	0.97466452
59	MP0001905_abnormal_dopamine_level	0.96290862
60	MP0001440_abnormal_grooming_behavior	0.95780432
61	MP0001853_heart_inflammation	0.95082759
62	MP0002163_abnormal_gland_morphology	0.94946072
63	MP0000427_abnormal_hair_cycle	0.93102689
64	MP0003186_abnormal_redox_activity	0.91903494
65	MP0003385_abnormal_body_wall	0.88724494
66	MP0009250_abnormal_appendicular_skeleto	0.85934331
67	MP0001835_abnormal_antigen_presentation	0.83592575
68	MP0005195_abnormal_posterior_eye	0.83129937
69	MP0002160_abnormal_reproductive_system	0.82848067
70	MP0005085_abnormal_gallbladder_physiolo	0.81706219
71	MP0009046_muscle_twitch	0.80984598
72	MP0005389_reproductive_system_phenotype	0.79581989
73	MP0001501_abnormal_sleep_pattern	0.78921232
74	MP0008877_abnormal_DNA_methylation	0.78362545
75	MP0004858_abnormal_nervous_system	0.78121026
76	MP0000631_abnormal_neuroendocrine_gland	0.76051513
77	MP0001800_abnormal_humoral_immune	0.72056635
78	MP0000383_abnormal_hair_follicle	0.71147518
79	MP0006036_abnormal_mitochondrial_physio	0.70724155
80	MP0002734_abnormal_mechanical_nocicepti	0.70006771
81	MP0002752_abnormal_somatic_nervous	0.69761346
82	MP0001970_abnormal_pain_threshold	0.69646983
83	MP0005423_abnormal_somatic_nervous	0.69209788
84	MP0006276_abnormal_autonomic_nervous	0.67562751
85	MP0005248_abnormal_Harderian_gland	0.66515769
86	MP0009745_abnormal_behavioral_response	0.64865920
87	MP0003938_abnormal_ear_development	0.64312901
88	MP0008932_abnormal_embryonic_tissue	0.64016453
89	MP0000639_abnormal_adrenal_gland	0.63796306
90	MP0002210_abnormal_sex_determination	0.61935835
91	MP0001919_abnormal_reproductive_system	0.61843634
92	MP0002557_abnormal_social/conspecific_i	0.60049455
93	MP0002909_abnormal_adrenal_gland	0.58648002
94	MP0002233_abnormal_nose_morphology	0.57070004
95	MP0002249_abnormal_larynx_morphology	0.55275906
96	MP0003633_abnormal_nervous_system	0.55064783
97	MP0003252_abnormal_bile_duct	0.54363953
98	MP0005332_abnormal_amino_acid	0.53421497
99	MP0000613_abnormal_salivary_gland	0.51542788
100	MP0002735_abnormal_chemical_nociception	0.51111361

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.72798746
2	Abnormal mitochondria in muscle tissue (HP:0008316)	4.34985236
3	Acute encephalopathy (HP:0006846)	4.32067665
4	Mitochondrial inheritance (HP:0001427)	3.94673818
5	Congenital, generalized hypertrichosis (HP:0004540)	3.93110987
6	Elevated erythrocyte sedimentation rate (HP:0003565)	3.92517668
7	Progressive macrocephaly (HP:0004481)	3.85894441
8	Reticulocytopenia (HP:0001896)	3.64614858
9	Panhypogammaglobulinemia (HP:0003139)	3.63928416
10	Pancreatic fibrosis (HP:0100732)	3.39826927
11	Type II lissencephaly (HP:0007260)	3.35813826
12	Increased CSF lactate (HP:0002490)	3.34065651
13	Abnormality of cells of the erythroid lineage (HP:0012130)	3.26485858
14	Hepatocellular necrosis (HP:0001404)	3.09045251
15	True hermaphroditism (HP:0010459)	3.06612907
16	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.02076156
17	Pancreatic cysts (HP:0001737)	3.01493093
18	Cerebral edema (HP:0002181)	2.93306512
19	Lipid accumulation in hepatocytes (HP:0006561)	2.84887886
20	Molar tooth sign on MRI (HP:0002419)	2.83349721
21	Abnormality of midbrain morphology (HP:0002418)	2.83349721
22	Dry hair (HP:0011359)	2.79255931
23	Increased hepatocellular lipid droplets (HP:0006565)	2.75908235
24	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.74640984
25	Hepatic necrosis (HP:0002605)	2.64669901
26	Abnormal number of erythroid precursors (HP:0012131)	2.56096031
27	Recurrent cutaneous fungal infections (HP:0011370)	2.55357438
28	Chronic mucocutaneous candidiasis (HP:0002728)	2.55357438
29	Cerebellar dysplasia (HP:0007033)	2.54786700
30	Woolly hair (HP:0002224)	2.54730715
31	3-Methylglutaconic aciduria (HP:0003535)	2.50639582
32	Type I transferrin isoform profile (HP:0003642)	2.47078330
33	Agammaglobulinemia (HP:0004432)	2.46097523
34	Increased intramyocellular lipid droplets (HP:0012240)	2.35182174
35	Absent thumb (HP:0009777)	2.33415009
36	Testicular atrophy (HP:0000029)	2.27809904
37	Macrocytic anemia (HP:0001972)	2.26418793
38	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.22641253
39	Cystic liver disease (HP:0006706)	2.22058977
40	Optic disc pallor (HP:0000543)	2.21442911
41	Tubulointerstitial fibrosis (HP:0005576)	2.19884838
42	Abnormality of the proximal phalanges of the hand (HP:0009834)	2.14713506
43	Increased muscle lipid content (HP:0009058)	2.13004584
44	Abnormality of DNA repair (HP:0003254)	2.11974047
45	Supernumerary spleens (HP:0009799)	2.11442996
46	Nephronophthisis (HP:0000090)	2.10030887
47	Encephalitis (HP:0002383)	2.10008064
48	Leukodystrophy (HP:0002415)	2.09038299
49	Tubular atrophy (HP:0000092)	2.08693790
50	Optic nerve hypoplasia (HP:0000609)	2.07899666
51	Abnormality of the axillary hair (HP:0100134)	2.07054205
52	Abnormality of secondary sexual hair (HP:0009888)	2.07054205
53	B lymphocytopenia (HP:0010976)	2.06401242
54	Bile duct proliferation (HP:0001408)	2.05520838
55	Abnormal biliary tract physiology (HP:0012439)	2.05520838
56	Abnormal respiratory motile cilium physiology (HP:0012261)	2.05313455
57	Severe combined immunodeficiency (HP:0004430)	2.03450424
58	Lethargy (HP:0001254)	2.02920664
59	Respiratory failure (HP:0002878)	2.02531837
60	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.01979510
61	Septo-optic dysplasia (HP:0100842)	2.01875294
62	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.01166087
63	Abnormality of T cell physiology (HP:0011840)	2.00349091
64	Abnormality of the renal medulla (HP:0100957)	1.99731067
65	Volvulus (HP:0002580)	1.99271645
66	Lactic acidosis (HP:0003128)	1.96518277
67	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.95375304
68	Mesangial abnormality (HP:0001966)	1.91659949
69	Increased serum lactate (HP:0002151)	1.91267398
70	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.90025661
71	Delayed epiphyseal ossification (HP:0002663)	1.88882728
72	Hypothermia (HP:0002045)	1.88181047
73	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.86134419
74	Nonprogressive disorder (HP:0003680)	1.84966733
75	Sclerocornea (HP:0000647)	1.83780624
76	Mesomelia (HP:0003027)	1.83275550
77	Abnormality of the renal collecting system (HP:0004742)	1.82407805
78	Absent/shortened dynein arms (HP:0200106)	1.81978021
79	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.81978021
80	Male pseudohermaphroditism (HP:0000037)	1.81483905
81	Hypoplasia of the radius (HP:0002984)	1.81356124
82	Abnormality of B cell number (HP:0010975)	1.78537039
83	11 pairs of ribs (HP:0000878)	1.77929169
84	Pallor (HP:0000980)	1.77400385
85	Renal Fanconi syndrome (HP:0001994)	1.77042301
86	Growth hormone deficiency (HP:0000824)	1.76705400
87	Congenital hepatic fibrosis (HP:0002612)	1.76498587
88	Neutropenia (HP:0001875)	1.74813558
89	Abnormal respiratory epithelium morphology (HP:0012253)	1.74464693
90	Abnormal respiratory motile cilium morphology (HP:0005938)	1.74464693
91	Small hand (HP:0200055)	1.73829841
92	Abnormality of the ileum (HP:0001549)	1.73518693
93	Exercise intolerance (HP:0003546)	1.73123827
94	Oligodactyly (hands) (HP:0001180)	1.72521354
95	Colon cancer (HP:0003003)	1.72146158
96	Irregular epiphyses (HP:0010582)	1.71424748
97	Asplenia (HP:0001746)	1.70182239
98	Chromsome breakage (HP:0040012)	1.69006095
99	Congenital ichthyosiform erythroderma (HP:0007431)	1.68485117
100	Chronic hepatic failure (HP:0100626)	1.68121729

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BMPR1B	5.80698758
2	CDK8	4.36734388
3	GRK1	4.03473904
4	ERN1	3.29536363
5	ADRBK2	2.99131291
6	BCKDK	2.89812380
7	MAP4K2	2.76570245
8	TGFBR1	2.72101850
9	MAP3K12	2.67373752
10	MST4	2.37328110
11	ZAK	2.24501616
12	DYRK2	1.76997258
13	VRK2	1.76325621
14	TIE1	1.74372133
15	FRK	1.63926820
16	PLK4	1.59218543
17	MAPKAPK3	1.49434949
18	TLK1	1.45701207
19	KIT	1.45323962
20	LRRK2	1.45105687
21	WNK4	1.38484090
22	STK38L	1.32218454
23	DAPK1	1.25502064
24	PLK2	1.21978961
25	EPHB2	1.21166958
26	STK16	1.17826816
27	TXK	1.17772064
28	TAOK3	1.14712415
29	DAPK3	1.09437367
30	WNK3	1.07498235
31	VRK1	1.06333596
32	NME1	1.05284364
33	AURKB	1.03473581
34	RIPK4	1.02329220
35	KDR	0.98657016
36	MYLK	0.93512170
37	ERBB3	0.91214130
38	ITK	0.87782723
39	TRIM28	0.86702719
40	TRPM7	0.86525766
41	BCR	0.85509707
42	MAPK13	0.83203704
43	CDK9	0.82767079
44	WEE1	0.79322858
45	PRKCI	0.78881623
46	CDK7	0.77729856
47	STK11	0.76420829
48	TAF1	0.73456171
49	TEC	0.71482137
50	EPHA4	0.71283232
51	LYN	0.68352515
52	BMPR2	0.68290186
53	SYK	0.68230309
54	NEK2	0.66785289
55	NUAK1	0.66199824
56	ABL2	0.64232901
57	PHKG1	0.63496797
58	PHKG2	0.63496797
59	ATR	0.61813238
60	INSRR	0.60024045
61	PASK	0.59477067
62	DAPK2	0.56336896
63	NTRK3	0.54250833
64	OBSCN	0.50719242
65	EIF2AK1	0.50595925
66	MET	0.46305796
67	ADRBK1	0.46129233
68	TNK2	0.45650018
69	PRKACA	0.43603740
70	PRKCA	0.43393396
71	PLK1	0.42912723
72	PLK3	0.42880984
73	TESK2	0.42464682
74	ERBB2	0.42311285
75	CSNK1A1	0.41749847
76	CSNK2A1	0.41566580
77	CSNK2A2	0.40838825
78	MAP2K7	0.40458040
79	BTK	0.40453316
80	PRKCG	0.40283473
81	PRKCH	0.38176680
82	PKN1	0.37956847
83	RPS6KA6	0.37628630
84	ILK	0.37204085
85	TYK2	0.36649422
86	GRK5	0.36495839
87	SGK1	0.36111716
88	IKBKB	0.32298298
89	PAK3	0.31281503
90	CDC7	0.31072808
91	PIK3CA	0.30154935
92	MAPKAPK5	0.30016564
93	PRKCE	0.29968016
94	EGFR	0.29852816
95	CSNK1G3	0.29492157
96	MAP3K4	0.27990535
97	RPS6KL1	0.27325959
98	RPS6KC1	0.27325959
99	FES	0.27217667
100	CDK15	0.26813490

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	4.12903634
2	Ribosome_Homo sapiens_hsa03010	3.87928318
3	Parkinsons disease_Homo sapiens_hsa05012	3.38922424
4	Asthma_Homo sapiens_hsa05310	3.07193547
5	Proteasome_Homo sapiens_hsa03050	3.01276346
6	DNA replication_Homo sapiens_hsa03030	2.58869278
7	Huntingtons disease_Homo sapiens_hsa05016	2.53876767
8	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.50288291
9	Cardiac muscle contraction_Homo sapiens_hsa04260	2.49352055
10	Allograft rejection_Homo sapiens_hsa05330	2.45976268
11	Alzheimers disease_Homo sapiens_hsa05010	2.43393751
12	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.35810528
13	Graft-versus-host disease_Homo sapiens_hsa05332	2.35335607
14	Mismatch repair_Homo sapiens_hsa03430	2.21504328
15	One carbon pool by folate_Homo sapiens_hsa00670	2.16215480
16	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.11649535
17	Type I diabetes mellitus_Homo sapiens_hsa04940	2.07149778
18	Fanconi anemia pathway_Homo sapiens_hsa03460	1.89540117
19	RNA degradation_Homo sapiens_hsa03018	1.88760272
20	Antigen processing and presentation_Homo sapiens_hsa04612	1.77674769
21	Primary immunodeficiency_Homo sapiens_hsa05340	1.74793912
22	Nucleotide excision repair_Homo sapiens_hsa03420	1.67815359
23	Non-homologous end-joining_Homo sapiens_hsa03450	1.62001743
24	RNA polymerase_Homo sapiens_hsa03020	1.59616457
25	Homologous recombination_Homo sapiens_hsa03440	1.52144301
26	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.48366439
27	Protein export_Homo sapiens_hsa03060	1.44927599
28	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.42880029
29	Propanoate metabolism_Homo sapiens_hsa00640	1.34483700
30	Folate biosynthesis_Homo sapiens_hsa00790	1.33240097
31	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.29629218
32	Basal transcription factors_Homo sapiens_hsa03022	1.24620868
33	Base excision repair_Homo sapiens_hsa03410	1.17339543
34	Phototransduction_Homo sapiens_hsa04744	1.13042338
35	Rheumatoid arthritis_Homo sapiens_hsa05323	1.08311661
36	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.05066552
37	Spliceosome_Homo sapiens_hsa03040	0.99958129
38	Fatty acid degradation_Homo sapiens_hsa00071	0.97764281
39	Nitrogen metabolism_Homo sapiens_hsa00910	0.97579162
40	Pyrimidine metabolism_Homo sapiens_hsa00240	0.95795365
41	Linoleic acid metabolism_Homo sapiens_hsa00591	0.94793148
42	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.92653889
43	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.87133107
44	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.83374752
45	Tryptophan metabolism_Homo sapiens_hsa00380	0.82607201
46	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.81557967
47	Chemical carcinogenesis_Homo sapiens_hsa05204	0.77504228
48	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.76070199
49	Sulfur relay system_Homo sapiens_hsa04122	0.75789216
50	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.75430152
51	Fatty acid metabolism_Homo sapiens_hsa01212	0.71452681
52	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.70680029
53	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.70093709
54	Glutathione metabolism_Homo sapiens_hsa00480	0.69860004
55	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.67183981
56	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.66464057
57	Fatty acid elongation_Homo sapiens_hsa00062	0.65656824
58	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.64083194
59	Purine metabolism_Homo sapiens_hsa00230	0.62463850
60	Mineral absorption_Homo sapiens_hsa04978	0.62033498
61	Viral myocarditis_Homo sapiens_hsa05416	0.61473341
62	Peroxisome_Homo sapiens_hsa04146	0.61152908
63	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.60194794
64	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.60075333
65	Basal cell carcinoma_Homo sapiens_hsa05217	0.59515579
66	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.59343071
67	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.58961556
68	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.57607488
69	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.56788223
70	Regulation of autophagy_Homo sapiens_hsa04140	0.54861108
71	Butanoate metabolism_Homo sapiens_hsa00650	0.54181687
72	Metabolic pathways_Homo sapiens_hsa01100	0.47938060
73	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.47285068
74	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.45381359
75	Leishmaniasis_Homo sapiens_hsa05140	0.44941922
76	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.44918526
77	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.44287788
78	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.42948683
79	Olfactory transduction_Homo sapiens_hsa04740	0.41599986
80	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.39893735
81	Retinol metabolism_Homo sapiens_hsa00830	0.39199650
82	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.37589653
83	Tuberculosis_Homo sapiens_hsa05152	0.36552453
84	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.36217051
85	Pyruvate metabolism_Homo sapiens_hsa00620	0.31825897
86	Herpes simplex infection_Homo sapiens_hsa05168	0.31403157
87	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.31321134
88	Collecting duct acid secretion_Homo sapiens_hsa04966	0.30695146
89	Fat digestion and absorption_Homo sapiens_hsa04975	0.29060212
90	Ether lipid metabolism_Homo sapiens_hsa00565	0.28345362
91	Alcoholism_Homo sapiens_hsa05034	0.28161310
92	Steroid biosynthesis_Homo sapiens_hsa00100	0.28051034
93	Cell cycle_Homo sapiens_hsa04110	0.27608250
94	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.26027992
95	Caffeine metabolism_Homo sapiens_hsa00232	0.21813142
96	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.19878128
97	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.17183456
98	RNA transport_Homo sapiens_hsa03013	0.15839099
99	Taste transduction_Homo sapiens_hsa04742	0.14711795
100	Phagosome_Homo sapiens_hsa04145	0.14218518

SNRPEP7

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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