ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	chaperone-mediated protein transport (GO:0072321)	5.71737659
2	ATP synthesis coupled proton transport (GO:0015986)	5.40674452
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.40674452
4	establishment of protein localization to mitochondrial membrane (GO:0090151)	5.34620330
5	protein neddylation (GO:0045116)	4.90922384
6	ribosomal small subunit biogenesis (GO:0042274)	4.88173909
7	maturation of SSU-rRNA (GO:0030490)	4.82042985
8	ribosomal small subunit assembly (GO:0000028)	4.76724674
9	viral transcription (GO:0019083)	4.71836768
10	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.71804933
11	translational termination (GO:0006415)	4.62848014
12	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.29194631
13	ribosomal large subunit biogenesis (GO:0042273)	4.27111859
14	cotranslational protein targeting to membrane (GO:0006613)	4.22091093
15	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.21745705
16	NADH dehydrogenase complex assembly (GO:0010257)	4.21745705
17	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.21745705
18	protein targeting to ER (GO:0045047)	4.17870353
19	protein complex biogenesis (GO:0070271)	4.14164648
20	mitochondrial respiratory chain complex assembly (GO:0033108)	4.13665599
21	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.09565574
22	chromatin remodeling at centromere (GO:0031055)	4.08089011
23	translational elongation (GO:0006414)	4.05716567
24	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.00544375
25	DNA deamination (GO:0045006)	4.00317685
26	protein localization to endoplasmic reticulum (GO:0070972)	3.92097321
27	pseudouridine synthesis (GO:0001522)	3.87720945
28	GTP biosynthetic process (GO:0006183)	3.85889570
29	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.83303331
30	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.83028696
31	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.83028696
32	DNA replication checkpoint (GO:0000076)	3.74661371
33	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.74225499
34	translation (GO:0006412)	3.72269449
35	water-soluble vitamin biosynthetic process (GO:0042364)	3.70742042
36	ribonucleoprotein complex biogenesis (GO:0022613)	3.68572815
37	cellular component biogenesis (GO:0044085)	3.68254012
38	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.67391164
39	termination of RNA polymerase III transcription (GO:0006386)	3.67391164
40	respiratory electron transport chain (GO:0022904)	3.63143217
41	DNA double-strand break processing (GO:0000729)	3.62829359
42	respiratory chain complex IV assembly (GO:0008535)	3.62728477
43	electron transport chain (GO:0022900)	3.62562997
44	protein targeting to mitochondrion (GO:0006626)	3.61803986
45	rRNA modification (GO:0000154)	3.59604381
46	CENP-A containing nucleosome assembly (GO:0034080)	3.56395638
47	translational initiation (GO:0006413)	3.52359037
48	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.51302033
49	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.51225418
50	rRNA processing (GO:0006364)	3.50129777
51	cellular protein complex disassembly (GO:0043624)	3.49891192
52	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.46924441
53	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.45678565
54	rRNA metabolic process (GO:0016072)	3.42915909
55	establishment of protein localization to mitochondrion (GO:0072655)	3.39800605
56	maturation of 5.8S rRNA (GO:0000460)	3.39342364
57	viral life cycle (GO:0019058)	3.39028435
58	UTP biosynthetic process (GO:0006228)	3.35375612
59	ATP biosynthetic process (GO:0006754)	3.34619663
60	protein localization to mitochondrion (GO:0070585)	3.32652272
61	CTP biosynthetic process (GO:0006241)	3.32044746
62	CTP metabolic process (GO:0046036)	3.32044746
63	kinetochore assembly (GO:0051382)	3.32005703
64	tRNA processing (GO:0008033)	3.27094877
65	ubiquinone biosynthetic process (GO:0006744)	3.23440817
66	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.23027071
67	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	3.20050955
68	cytochrome complex assembly (GO:0017004)	3.19223031
69	kinetochore organization (GO:0051383)	3.14424404
70	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	3.12984683
71	UTP metabolic process (GO:0046051)	3.12151325
72	ribosome biogenesis (GO:0042254)	3.11162733
73	guanosine-containing compound biosynthetic process (GO:1901070)	3.09507930
74	purine nucleobase biosynthetic process (GO:0009113)	3.09383489
75	cullin deneddylation (GO:0010388)	3.07077455
76	protein complex disassembly (GO:0043241)	3.06019489
77	histone exchange (GO:0043486)	3.04901439
78	protein deneddylation (GO:0000338)	3.04226113
79	nucleobase biosynthetic process (GO:0046112)	3.03013800
80	pyrimidine nucleotide catabolic process (GO:0006244)	3.01252525
81	peptidyl-histidine modification (GO:0018202)	3.01138001
82	DNA damage response, detection of DNA damage (GO:0042769)	3.00906405
83	intracellular protein transmembrane import (GO:0044743)	3.00073220
84	behavioral response to nicotine (GO:0035095)	2.99804729
85	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.98553822
86	inner mitochondrial membrane organization (GO:0007007)	2.98524263
87	ncRNA processing (GO:0034470)	2.98044792
88	macromolecular complex disassembly (GO:0032984)	2.94263565
89	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.93955461
90	ubiquinone metabolic process (GO:0006743)	2.92922900
91	tRNA metabolic process (GO:0006399)	2.92572416
92	nucleoside triphosphate biosynthetic process (GO:0009142)	2.91542396
93	replication fork processing (GO:0031297)	2.90334605
94	histone mRNA metabolic process (GO:0008334)	2.90243086
95	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	2.90079052
96	resolution of meiotic recombination intermediates (GO:0000712)	2.85222768
97	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.84115008
98	ncRNA metabolic process (GO:0034660)	2.83677116
99	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	2.83379179
100	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.80488475

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	5.20290945
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.58998673
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.82210409
4	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.76159286
5	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.66933458
6	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.48302980
7	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.32080771
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.30030199
9	E2F7_22180533_ChIP-Seq_HELA_Human	3.17190265
10	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.79578686
11	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.74047713
12	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.71230212
13	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.64045912
14	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.63660308
15	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.60812969
16	VDR_23849224_ChIP-Seq_CD4+_Human	2.60357575
17	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.55518981
18	FOXP3_21729870_ChIP-Seq_TREG_Human	2.45489885
19	VDR_22108803_ChIP-Seq_LS180_Human	2.39510989
20	ELK1_19687146_ChIP-ChIP_HELA_Human	2.33978037
21	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.30406461
22	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.27069703
23	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.18732701
24	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.18062797
25	TTF2_22483619_ChIP-Seq_HELA_Human	2.16304119
26	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.13828296
27	GABP_19822575_ChIP-Seq_HepG2_Human	2.12212307
28	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.11730060
29	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.99517908
30	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.97258568
31	ZNF274_21170338_ChIP-Seq_K562_Hela	1.93827873
32	XRN2_22483619_ChIP-Seq_HELA_Human	1.93103734
33	MYC_18940864_ChIP-ChIP_HL60_Human	1.92831992
34	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.86853353
35	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.81575461
36	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.74676705
37	DCP1A_22483619_ChIP-Seq_HELA_Human	1.72487482
38	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.69834638
39	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.68888149
40	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.67000448
41	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.61728555
42	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.55070619
43	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.47102564
44	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.45335333
45	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.43515324
46	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.43034818
47	IRF1_19129219_ChIP-ChIP_H3396_Human	1.39663610
48	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.36168401
49	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.32393738
50	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.32324467
51	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.32133148
52	EWS_26573619_Chip-Seq_HEK293_Human	1.30976013
53	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.26617583
54	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.23758012
55	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.23188086
56	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.23015782
57	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.20387224
58	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.17381710
59	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.15141576
60	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.13278236
61	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.12588918
62	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.09239162
63	TP53_22573176_ChIP-Seq_HFKS_Human	1.08240256
64	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.08214817
65	KDM5A_27292631_Chip-Seq_BREAST_Human	1.05532360
66	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.03992751
67	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.03544017
68	FUS_26573619_Chip-Seq_HEK293_Human	1.02340859
69	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.01437193
70	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.01322134
71	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.00731944
72	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.98633205
73	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.93520333
74	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.93282998
75	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.92999561
76	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.90223013
77	NANOG_20526341_ChIP-Seq_ESCs_Human	0.89993991
78	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.89246448
79	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.89018049
80	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.88815775
81	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.88815775
82	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.88706295
83	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.87741068
84	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.87525277
85	NCOR_22424771_ChIP-Seq_293T_Human	0.87412775
86	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.87181500
87	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.86869254
88	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.86858297
89	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.86217649
90	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.85141059
91	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.84812556
92	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.84620704
93	EZH2_22144423_ChIP-Seq_EOC_Human	0.82313496
94	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.81834326
95	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.81580827
96	HOXB7_26014856_ChIP-Seq_BT474_Human	0.80568547
97	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.76694698
98	ERA_21632823_ChIP-Seq_H3396_Human	0.76197984
99	IGF1R_20145208_ChIP-Seq_DFB_Human	0.73788519
100	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.73782638

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	5.35998754
2	MP0009379_abnormal_foot_pigmentation	3.44378012
3	MP0008789_abnormal_olfactory_epithelium	2.96101329
4	MP0008058_abnormal_DNA_repair	2.69349730
5	MP0003693_abnormal_embryo_hatching	2.60582573
6	MP0003787_abnormal_imprinting	2.58380019
7	MP0005499_abnormal_olfactory_system	2.55028762
8	MP0005394_taste/olfaction_phenotype	2.55028762
9	MP0008877_abnormal_DNA_methylation	2.51596333
10	MP0002163_abnormal_gland_morphology	2.36257436
11	MP0004147_increased_porphyrin_level	2.28389267
12	MP0003123_paternal_imprinting	2.16771347
13	MP0001293_anophthalmia	2.07426949
14	MP0002837_dystrophic_cardiac_calcinosis	1.97111547
15	MP0010030_abnormal_orbit_morphology	1.96447815
16	MP0002102_abnormal_ear_morphology	1.93781721
17	MP0005084_abnormal_gallbladder_morpholo	1.93779517
18	MP0010094_abnormal_chromosome_stability	1.93298790
19	MP0003121_genomic_imprinting	1.88119624
20	MP0004957_abnormal_blastocyst_morpholog	1.78660361
21	MP0002938_white_spotting	1.75562512
22	MP0006072_abnormal_retinal_apoptosis	1.75076175
23	MP0001529_abnormal_vocalization	1.68523462
24	MP0004133_heterotaxia	1.61538099
25	MP0001188_hyperpigmentation	1.58637278
26	MP0002736_abnormal_nociception_after	1.58316559
27	MP0003122_maternal_imprinting	1.58182764
28	MP0006036_abnormal_mitochondrial_physio	1.56850915
29	MP0001485_abnormal_pinna_reflex	1.54964787
30	MP0000049_abnormal_middle_ear	1.54324711
31	MP0008007_abnormal_cellular_replicative	1.51870563
32	MP0003195_calcinosis	1.48623321
33	MP0008872_abnormal_physiological_respon	1.47533577
34	MP0003786_premature_aging	1.46538597
35	MP0003111_abnormal_nucleus_morphology	1.45953172
36	MP0003937_abnormal_limbs/digits/tail_de	1.45361052
37	MP0002234_abnormal_pharynx_morphology	1.43325221
38	MP0008932_abnormal_embryonic_tissue	1.42838532
39	MP0005646_abnormal_pituitary_gland	1.37275091
40	MP0003718_maternal_effect	1.36240005
41	MP0002160_abnormal_reproductive_system	1.35817899
42	MP0006276_abnormal_autonomic_nervous	1.35272982
43	MP0005379_endocrine/exocrine_gland_phen	1.34866353
44	MP0003077_abnormal_cell_cycle	1.28556198
45	MP0008775_abnormal_heart_ventricle	1.26902784
46	MP0004145_abnormal_muscle_electrophysio	1.26088040
47	MP0001968_abnormal_touch/_nociception	1.24495889
48	MP0003186_abnormal_redox_activity	1.24007885
49	MP0001984_abnormal_olfaction	1.22845985
50	MP0004142_abnormal_muscle_tone	1.21511751
51	MP0000631_abnormal_neuroendocrine_gland	1.16899655
52	MP0003567_abnormal_fetal_cardiomyocyte	1.16645834
53	MP0005551_abnormal_eye_electrophysiolog	1.15558126
54	MP0003806_abnormal_nucleotide_metabolis	1.14647408
55	MP0005389_reproductive_system_phenotype	1.12293807
56	MP0002210_abnormal_sex_determination	1.10234647
57	MP0003646_muscle_fatigue	1.08297306
58	MP0003011_delayed_dark_adaptation	1.08180161
59	MP0003119_abnormal_digestive_system	1.06510941
60	MP0003890_abnormal_embryonic-extraembry	1.05942979
61	MP0009053_abnormal_anal_canal	1.04867197
62	MP0005377_hearing/vestibular/ear_phenot	1.02764964
63	MP0003878_abnormal_ear_physiology	1.02764964
64	MP0002272_abnormal_nervous_system	1.02253553
65	MP0006035_abnormal_mitochondrial_morpho	1.02234201
66	MP0001986_abnormal_taste_sensitivity	1.00490113
67	MP0008875_abnormal_xenobiotic_pharmacok	0.99865463
68	MP0001348_abnormal_lacrimal_gland	0.97953022
69	MP0002233_abnormal_nose_morphology	0.97890745
70	MP0004885_abnormal_endolymph	0.97252395
71	MP0001905_abnormal_dopamine_level	0.97202503
72	MP0000372_irregular_coat_pigmentation	0.96367790
73	MP0005645_abnormal_hypothalamus_physiol	0.89966419
74	MP0001929_abnormal_gametogenesis	0.89456131
75	MP0003880_abnormal_central_pattern	0.88228815
76	MP0005195_abnormal_posterior_eye	0.86717032
77	MP0005075_abnormal_melanosome_morpholog	0.86137701
78	MP0002876_abnormal_thyroid_physiology	0.86108450
79	MP0001145_abnormal_male_reproductive	0.85957207
80	MP0001286_abnormal_eye_development	0.85209138
81	MP0005253_abnormal_eye_physiology	0.84913541
82	MP0000653_abnormal_sex_gland	0.84543458
83	MP0002277_abnormal_respiratory_mucosa	0.83715195
84	MP0001919_abnormal_reproductive_system	0.82384985
85	MP0002184_abnormal_innervation	0.82251098
86	MP0009046_muscle_twitch	0.79498759
87	MP0003936_abnormal_reproductive_system	0.77754110
88	MP0002752_abnormal_somatic_nervous	0.75463576
89	MP0002638_abnormal_pupillary_reflex	0.74227444
90	MP0002653_abnormal_ependyma_morphology	0.73212326
91	MP0005332_abnormal_amino_acid	0.72149316
92	MP0001119_abnormal_female_reproductive	0.71415794
93	MP0001764_abnormal_homeostasis	0.70253074
94	MP0005636_abnormal_mineral_homeostasis	0.69642397
95	MP0002095_abnormal_skin_pigmentation	0.68046009
96	MP0005083_abnormal_biliary_tract	0.68001353
97	MP0004742_abnormal_vestibular_system	0.67944841
98	MP0003938_abnormal_ear_development	0.67701278
99	MP0000778_abnormal_nervous_system	0.67532019
100	MP0005391_vision/eye_phenotype	0.66012646

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.83292641
2	Acute encephalopathy (HP:0006846)	4.44821296
3	Abnormal mitochondria in muscle tissue (HP:0008316)	4.34207719
4	Progressive macrocephaly (HP:0004481)	3.92138896
5	Mitochondrial inheritance (HP:0001427)	3.89920025
6	Reticulocytopenia (HP:0001896)	3.75694376
7	Increased CSF lactate (HP:0002490)	3.71758453
8	3-Methylglutaconic aciduria (HP:0003535)	3.67540888
9	Colon cancer (HP:0003003)	3.31667026
10	Cerebral edema (HP:0002181)	3.17797175
11	Increased hepatocellular lipid droplets (HP:0006565)	3.17691117
12	Abnormality of cells of the erythroid lineage (HP:0012130)	3.16215507
13	Abnormality of midbrain morphology (HP:0002418)	3.14193887
14	Molar tooth sign on MRI (HP:0002419)	3.14193887
15	Hepatocellular necrosis (HP:0001404)	3.11781517
16	Pancreatic cysts (HP:0001737)	2.98904133
17	Pancreatic fibrosis (HP:0100732)	2.95729577
18	Macrocytic anemia (HP:0001972)	2.89716768
19	Increased serum lactate (HP:0002151)	2.88395799
20	Abnormality of alanine metabolism (HP:0010916)	2.88310909
21	Hyperalaninemia (HP:0003348)	2.88310909
22	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.88310909
23	Lipid accumulation in hepatocytes (HP:0006561)	2.87182961
24	Abnormal number of erythroid precursors (HP:0012131)	2.74401198
25	Hepatic necrosis (HP:0002605)	2.72249581
26	Adrenal hypoplasia (HP:0000835)	2.68367037
27	Nephronophthisis (HP:0000090)	2.68066905
28	Hyperglycinemia (HP:0002154)	2.67776725
29	Lactic acidosis (HP:0003128)	2.65415951
30	Renal Fanconi syndrome (HP:0001994)	2.64320014
31	Abnormality of the labia minora (HP:0012880)	2.57978684
32	Absent thumb (HP:0009777)	2.53196651
33	Sclerocornea (HP:0000647)	2.47276189
34	Optic disc pallor (HP:0000543)	2.38263321
35	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.32853484
36	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.32853484
37	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.31983722
38	Leukodystrophy (HP:0002415)	2.30993442
39	Increased intramyocellular lipid droplets (HP:0012240)	2.30320037
40	Tubular atrophy (HP:0000092)	2.30155362
41	Asplenia (HP:0001746)	2.30031711
42	True hermaphroditism (HP:0010459)	2.29076725
43	Abnormality of the renal medulla (HP:0100957)	2.23288308
44	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.22854320
45	Septo-optic dysplasia (HP:0100842)	2.21747033
46	Pendular nystagmus (HP:0012043)	2.20516956
47	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.20051602
48	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.16799669
49	Exercise intolerance (HP:0003546)	2.16692726
50	Ectopic kidney (HP:0000086)	2.15374470
51	Type II lissencephaly (HP:0007260)	2.12306116
52	Congenital stationary night blindness (HP:0007642)	2.11715706
53	Respiratory failure (HP:0002878)	2.11374647
54	Meckel diverticulum (HP:0002245)	2.10305698
55	Microretrognathia (HP:0000308)	2.09618678
56	Medial flaring of the eyebrow (HP:0010747)	2.07904899
57	Bile duct proliferation (HP:0001408)	2.07070344
58	Abnormal biliary tract physiology (HP:0012439)	2.07070344
59	Respiratory difficulties (HP:0002880)	2.06484888
60	Abnormal rod and cone electroretinograms (HP:0008323)	2.05410114
61	Supernumerary spleens (HP:0009799)	2.05238361
62	Horseshoe kidney (HP:0000085)	2.04099640
63	Triphalangeal thumb (HP:0001199)	2.03256583
64	Lethargy (HP:0001254)	2.02295379
65	Methylmalonic acidemia (HP:0002912)	2.01813010
66	Methylmalonic aciduria (HP:0012120)	2.01636219
67	Pallor (HP:0000980)	2.01320049
68	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.00805049
69	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.00148627
70	Absent/shortened dynein arms (HP:0200106)	2.00148627
71	Exertional dyspnea (HP:0002875)	1.99710261
72	Abnormality of the ileum (HP:0001549)	1.99242142
73	Anencephaly (HP:0002323)	1.98550957
74	Hyperglycinuria (HP:0003108)	1.96476217
75	Abnormality of the renal cortex (HP:0011035)	1.94511939
76	Congenital, generalized hypertrichosis (HP:0004540)	1.94334028
77	Abnormality of serum amino acid levels (HP:0003112)	1.93448309
78	Abolished electroretinogram (ERG) (HP:0000550)	1.91331104
79	Congenital malformation of the right heart (HP:0011723)	1.90122863
80	Double outlet right ventricle (HP:0001719)	1.90122863
81	Abnormality of the pons (HP:0007361)	1.89666731
82	Polydipsia (HP:0001959)	1.87800323
83	Abnormal drinking behavior (HP:0030082)	1.87800323
84	Abnormality of glycine metabolism (HP:0010895)	1.86179553
85	Abnormality of serine family amino acid metabolism (HP:0010894)	1.86179553
86	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.84967548
87	Testicular atrophy (HP:0000029)	1.83877195
88	Hypoplasia of the pons (HP:0012110)	1.83617349
89	Type 2 muscle fiber atrophy (HP:0003554)	1.83605633
90	Anophthalmia (HP:0000528)	1.82301244
91	Abnormal number of incisors (HP:0011064)	1.81260846
92	Chromsome breakage (HP:0040012)	1.81005225
93	Pancytopenia (HP:0001876)	1.80371501
94	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.79007040
95	Increased muscle lipid content (HP:0009058)	1.77726800
96	Postaxial foot polydactyly (HP:0001830)	1.77300667
97	Abnormal lung lobation (HP:0002101)	1.74916996
98	Rib fusion (HP:0000902)	1.73639356
99	Abnormality of the preputium (HP:0100587)	1.73559007
100	Optic nerve coloboma (HP:0000588)	1.73454599

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NEK1	2.87832021
2	NUAK1	2.80763867
3	CDC7	2.69543409
4	STK16	2.66125300
5	TSSK6	2.59193501
6	ZAK	2.55933624
7	BUB1	2.50472300
8	MKNK2	2.47562484
9	VRK2	2.44099916
10	WNK4	2.41475596
11	WNK3	2.14325403
12	BCKDK	2.01862926
13	NME2	2.01299954
14	TIE1	1.95936450
15	PLK3	1.94656120
16	PLK4	1.90013494
17	EIF2AK1	1.79671925
18	ADRBK2	1.78381287
19	GRK1	1.75828023
20	MKNK1	1.70366132
21	TLK1	1.68746300
22	BMPR1B	1.58876424
23	STK39	1.57731031
24	MAP4K2	1.51684610
25	TAF1	1.51381082
26	TTK	1.46274467
27	OXSR1	1.41009319
28	SRPK1	1.38732542
29	TRIM28	1.31142859
30	PLK1	1.27981459
31	PIK3CA	1.25114800
32	TNIK	1.22992182
33	VRK1	1.22733930
34	DYRK2	1.22115248
35	ACVR1B	1.15328621
36	MAP2K7	1.12849657
37	TXK	1.12744483
38	MST4	1.12046651
39	FRK	1.11494593
40	PDK2	1.04178760
41	EIF2AK3	1.00389042
42	MAP3K11	1.00243482
43	CSNK1G2	0.98041005
44	CHEK2	0.97950741
45	EPHA4	0.97588046
46	TEC	0.97218440
47	CSNK1G3	0.96996915
48	ALK	0.95618140
49	AURKB	0.93696438
50	PINK1	0.93333624
51	ATR	0.89111037
52	CDK19	0.88400945
53	CSNK1G1	0.88148620
54	WEE1	0.85023002
55	PRKCG	0.83987968
56	NME1	0.83781901
57	DYRK3	0.83374465
58	MAP3K4	0.82089292
59	BRSK2	0.81740451
60	PASK	0.81616364
61	EIF2AK2	0.80609160
62	CSNK1A1L	0.76576770
63	BRAF	0.72968057
64	AURKA	0.71976124
65	TAOK3	0.71732245
66	CSNK2A2	0.69934607
67	BRSK1	0.66980940
68	INSRR	0.65504647
69	CSNK1E	0.61975246
70	PHKG1	0.61762718
71	PHKG2	0.61762718
72	CSNK2A1	0.60525845
73	NEK2	0.60402755
74	PRKCI	0.59331128
75	ATM	0.58978745
76	IKBKB	0.58691061
77	PBK	0.58387964
78	ITK	0.54774268
79	CAMKK2	0.52310917
80	ABL2	0.52287234
81	TGFBR1	0.51883269
82	CHEK1	0.51112375
83	RPS6KA5	0.49185960
84	CSNK1A1	0.47970313
85	ADRBK1	0.47931705
86	STK11	0.46326912
87	PLK2	0.45519716
88	PNCK	0.43113358
89	LRRK2	0.42939692
90	PAK3	0.41911958
91	DMPK	0.41521759
92	MINK1	0.41489663
93	MAP3K12	0.38330491
94	PRKACA	0.38109967
95	PRKDC	0.36742983
96	CASK	0.35837360
97	CAMK1	0.34533397
98	DAPK1	0.32994908
99	NTRK2	0.31722286
100	PRKCE	0.31069611

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.71799333
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.56810039
3	Proteasome_Homo sapiens_hsa03050	3.39793294
4	Parkinsons disease_Homo sapiens_hsa05012	3.00470120
5	RNA polymerase_Homo sapiens_hsa03020	2.95082904
6	Protein export_Homo sapiens_hsa03060	2.77470352
7	Mismatch repair_Homo sapiens_hsa03430	2.72663868
8	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.61443648
9	Homologous recombination_Homo sapiens_hsa03440	2.54481096
10	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.47384816
11	One carbon pool by folate_Homo sapiens_hsa00670	2.36348285
12	DNA replication_Homo sapiens_hsa03030	2.30413223
13	Huntingtons disease_Homo sapiens_hsa05016	2.19032491
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.06893492
15	Fanconi anemia pathway_Homo sapiens_hsa03460	2.06886184
16	Alzheimers disease_Homo sapiens_hsa05010	1.96069675
17	RNA degradation_Homo sapiens_hsa03018	1.90545851
18	Basal transcription factors_Homo sapiens_hsa03022	1.89315499
19	Pyrimidine metabolism_Homo sapiens_hsa00240	1.76266661
20	RNA transport_Homo sapiens_hsa03013	1.64797770
21	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.62845730
22	Nucleotide excision repair_Homo sapiens_hsa03420	1.61942731
23	Sulfur relay system_Homo sapiens_hsa04122	1.60738966
24	Cardiac muscle contraction_Homo sapiens_hsa04260	1.56798090
25	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.56263925
26	Spliceosome_Homo sapiens_hsa03040	1.53613743
27	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.53587859
28	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.52341407
29	Non-homologous end-joining_Homo sapiens_hsa03450	1.52258044
30	Propanoate metabolism_Homo sapiens_hsa00640	1.46119621
31	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.38304944
32	Base excision repair_Homo sapiens_hsa03410	1.37519295
33	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.35645122
34	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.34254562
35	Purine metabolism_Homo sapiens_hsa00230	1.25657513
36	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.18847680
37	Selenocompound metabolism_Homo sapiens_hsa00450	1.09315657
38	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.08755020
39	Phototransduction_Homo sapiens_hsa04744	1.07955439
40	Linoleic acid metabolism_Homo sapiens_hsa00591	1.06151311
41	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.02403765
42	Steroid biosynthesis_Homo sapiens_hsa00100	0.97541211
43	Asthma_Homo sapiens_hsa05310	0.96139117
44	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.89913427
45	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.89727207
46	Fatty acid elongation_Homo sapiens_hsa00062	0.89233668
47	Sulfur metabolism_Homo sapiens_hsa00920	0.88408889
48	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.87535607
49	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.85414170
50	Metabolic pathways_Homo sapiens_hsa01100	0.82794913
51	Tryptophan metabolism_Homo sapiens_hsa00380	0.80923199
52	Folate biosynthesis_Homo sapiens_hsa00790	0.78443627
53	Fat digestion and absorption_Homo sapiens_hsa04975	0.76794114
54	Peroxisome_Homo sapiens_hsa04146	0.71648537
55	Pyruvate metabolism_Homo sapiens_hsa00620	0.69844801
56	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.65077155
57	p53 signaling pathway_Homo sapiens_hsa04115	0.64592426
58	Glutathione metabolism_Homo sapiens_hsa00480	0.64411793
59	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.64075029
60	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.60580369
61	Cell cycle_Homo sapiens_hsa04110	0.59738861
62	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.59575272
63	Butanoate metabolism_Homo sapiens_hsa00650	0.59351942
64	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.57744453
65	Basal cell carcinoma_Homo sapiens_hsa05217	0.55937595
66	Ether lipid metabolism_Homo sapiens_hsa00565	0.55883776
67	Olfactory transduction_Homo sapiens_hsa04740	0.49972184
68	Caffeine metabolism_Homo sapiens_hsa00232	0.49224020
69	Nitrogen metabolism_Homo sapiens_hsa00910	0.49020899
70	Retinol metabolism_Homo sapiens_hsa00830	0.47833640
71	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.47358605
72	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.46389433
73	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.45628364
74	Chemical carcinogenesis_Homo sapiens_hsa05204	0.44711335
75	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.43944405
76	beta-Alanine metabolism_Homo sapiens_hsa00410	0.42635718
77	Fatty acid degradation_Homo sapiens_hsa00071	0.42547942
78	Collecting duct acid secretion_Homo sapiens_hsa04966	0.41938725
79	mRNA surveillance pathway_Homo sapiens_hsa03015	0.41365155
80	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.36842130
81	Carbon metabolism_Homo sapiens_hsa01200	0.36747184
82	Regulation of autophagy_Homo sapiens_hsa04140	0.35485487
83	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.33023959
84	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.32360543
85	Nicotine addiction_Homo sapiens_hsa05033	0.32173142
86	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.29704131
87	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.29430464
88	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.29222180
89	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.26869317
90	Fatty acid metabolism_Homo sapiens_hsa01212	0.26277726
91	Allograft rejection_Homo sapiens_hsa05330	0.25060688
92	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.24782817
93	Arginine and proline metabolism_Homo sapiens_hsa00330	0.24400947
94	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.23825072
95	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.23011234
96	Primary immunodeficiency_Homo sapiens_hsa05340	0.20816333
97	Type I diabetes mellitus_Homo sapiens_hsa04940	0.20286660
98	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.20240997
99	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.19892890
100	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.17715859

SNRPFP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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