SNRPG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a component of the U1, U2, U4, and U5 small nuclear ribonucleoprotein complexes, precursors of the spliceosome. The encoded protein may also be a part of the U7 small nuclear ribonucleoprotein complex, which participates in the processing of the 3' end of histone transcripts. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)7.37147069
2translational termination (GO:0006415)7.11169241
3ribosomal small subunit assembly (GO:0000028)7.08656439
4ribosomal small subunit biogenesis (GO:0042274)6.97611024
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.20613756
6maturation of SSU-rRNA (GO:0030490)6.13912543
7cotranslational protein targeting to membrane (GO:0006613)6.11109957
8translational elongation (GO:0006414)6.07026129
9protein targeting to ER (GO:0045047)6.06911016
10establishment of protein localization to endoplasmic reticulum (GO:0072599)5.76992018
11protein localization to endoplasmic reticulum (GO:0070972)5.70541892
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.57568134
13cellular protein complex disassembly (GO:0043624)5.57522915
14nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.55660140
15establishment of protein localization to mitochondrial membrane (GO:0090151)5.54113616
16viral life cycle (GO:0019058)5.53257038
17ribosomal large subunit biogenesis (GO:0042273)5.52560628
18translational initiation (GO:0006413)5.43155004
19chaperone-mediated protein transport (GO:0072321)5.42682787
20respiratory electron transport chain (GO:0022904)5.34264527
21electron transport chain (GO:0022900)5.22126903
22DNA deamination (GO:0045006)5.17337346
23protein complex disassembly (GO:0043241)4.88418378
24macromolecular complex disassembly (GO:0032984)4.61705210
25ribonucleoprotein complex biogenesis (GO:0022613)4.53609046
26telomere maintenance via semi-conservative replication (GO:0032201)4.42434933
27translation (GO:0006412)4.42382578
28protein complex biogenesis (GO:0070271)4.36840704
29DNA strand elongation involved in DNA replication (GO:0006271)4.29296859
30protein neddylation (GO:0045116)4.27367490
31mitochondrial respiratory chain complex assembly (GO:0033108)4.25387064
32nuclear-transcribed mRNA catabolic process (GO:0000956)4.21559601
33regulation of mitochondrial translation (GO:0070129)4.18895232
34CENP-A containing nucleosome assembly (GO:0034080)4.09738782
35DNA strand elongation (GO:0022616)4.09144185
36mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.07347538
37mitochondrial respiratory chain complex I assembly (GO:0032981)4.07347538
38NADH dehydrogenase complex assembly (GO:0010257)4.07347538
39proteasome assembly (GO:0043248)4.01014587
40mRNA catabolic process (GO:0006402)4.00056788
41chromatin remodeling at centromere (GO:0031055)3.99953865
42rRNA processing (GO:0006364)3.95977592
43termination of RNA polymerase III transcription (GO:0006386)3.95660440
44transcription elongation from RNA polymerase III promoter (GO:0006385)3.95660440
45protein targeting to membrane (GO:0006612)3.94150387
46telomere maintenance via recombination (GO:0000722)3.92034313
47DNA replication checkpoint (GO:0000076)3.89727262
48deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.85603303
49DNA replication initiation (GO:0006270)3.83992845
50rRNA metabolic process (GO:0016072)3.81593262
51kinetochore assembly (GO:0051382)3.78754025
52RNA catabolic process (GO:0006401)3.77147329
53kinetochore organization (GO:0051383)3.74463387
54* spliceosomal snRNP assembly (GO:0000387)3.73420785
55establishment of integrated proviral latency (GO:0075713)3.70402360
56mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.68991838
57cellular component biogenesis (GO:0044085)3.68355728
58mitotic recombination (GO:0006312)3.66488402
59regulation of cellular amino acid metabolic process (GO:0006521)3.65045287
60exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.63024355
61respiratory chain complex IV assembly (GO:0008535)3.61927235
62protein targeting to mitochondrion (GO:0006626)3.57725768
63ATP biosynthetic process (GO:0006754)3.54200050
64positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.53026650
65rRNA modification (GO:0000154)3.52947624
66telomere maintenance via telomere lengthening (GO:0010833)3.50786896
67DNA replication-independent nucleosome assembly (GO:0006336)3.50150016
68DNA replication-independent nucleosome organization (GO:0034724)3.50150016
69nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.49981827
70oxidative phosphorylation (GO:0006119)3.47822915
71cytochrome complex assembly (GO:0017004)3.47388352
72pseudouridine synthesis (GO:0001522)3.47360224
73formation of translation preinitiation complex (GO:0001731)3.46651588
74signal transduction involved in DNA integrity checkpoint (GO:0072401)3.46268923
75signal transduction involved in DNA damage checkpoint (GO:0072422)3.46268923
76energy coupled proton transport, down electrochemical gradient (GO:0015985)3.43788445
77ATP synthesis coupled proton transport (GO:0015986)3.43788445
78transcription-coupled nucleotide-excision repair (GO:0006283)3.43247314
79DNA damage response, detection of DNA damage (GO:0042769)3.43107678
80signal transduction involved in cell cycle checkpoint (GO:0072395)3.42887403
81mitotic metaphase plate congression (GO:0007080)3.39073109
82establishment of protein localization to mitochondrion (GO:0072655)3.38552226
83protein localization to mitochondrion (GO:0070585)3.38039469
84positive regulation of ligase activity (GO:0051351)3.37548442
85inner mitochondrial membrane organization (GO:0007007)3.36194765
86purine nucleoside triphosphate biosynthetic process (GO:0009145)3.35640175
87nucleotide-excision repair, DNA gap filling (GO:0006297)3.35490986
88negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.35277229
89purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.32409670
90hydrogen ion transmembrane transport (GO:1902600)3.29671114
91* spliceosomal complex assembly (GO:0000245)3.28615459
927-methylguanosine mRNA capping (GO:0006370)3.27566444
93RNA capping (GO:0036260)3.25311089
947-methylguanosine RNA capping (GO:0009452)3.25311089
95cullin deneddylation (GO:0010388)3.24983894
96ribosome biogenesis (GO:0042254)3.24444267
97regulation of ubiquitin-protein transferase activity (GO:0051438)3.22363549
98tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.21095948
99RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.21095948
100histone exchange (GO:0043486)3.18715085
101GTP biosynthetic process (GO:0006183)3.18354206
102anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.18082159
103regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.15882157
104regulation of mitotic spindle checkpoint (GO:1903504)3.15882157
105DNA double-strand break processing (GO:0000729)3.15265028
106regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.14783550
107positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.13388504
108rRNA methylation (GO:0031167)3.10956770
109regulation of ligase activity (GO:0051340)3.10632694
110negative regulation of ligase activity (GO:0051352)3.08241054
111negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.08241054
112transcription elongation from RNA polymerase I promoter (GO:0006362)3.02710858
113metaphase plate congression (GO:0051310)3.02501985
114UTP biosynthetic process (GO:0006228)3.00795262
115viral mRNA export from host cell nucleus (GO:0046784)3.00547718
116termination of RNA polymerase I transcription (GO:0006363)2.98679686
117deoxyribonucleotide biosynthetic process (GO:0009263)2.97944968
118regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.96559054
119ribosome assembly (GO:0042255)2.95735828
120nucleobase biosynthetic process (GO:0046112)2.95081799
121pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.94313802
122establishment of viral latency (GO:0019043)2.94133022
123pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.93940947
124pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.92610388
125transcription from RNA polymerase I promoter (GO:0006360)2.92164603
126DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.91564255
127protein localization to kinetochore (GO:0034501)2.91091367
128ncRNA processing (GO:0034470)2.88975341
129DNA unwinding involved in DNA replication (GO:0006268)2.87206966
130signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.86380432
131intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.86380432
132signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.84861019
133signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.84861019
134signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.84861019
135pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.81350515
136DNA replication-dependent nucleosome organization (GO:0034723)2.81214844
137DNA replication-dependent nucleosome assembly (GO:0006335)2.81214844
138protein localization to chromosome, centromeric region (GO:0071459)2.80258006
139purine nucleobase biosynthetic process (GO:0009113)2.80036189

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.99945082
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.87563756
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.16561406
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.94094934
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.82365366
6* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.72774108
7* EST1_17652178_ChIP-ChIP_JURKAT_Human3.72620290
8* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.44140274
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.38806424
10* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.37381725
11* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.35575877
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.19543230
13CREB1_15753290_ChIP-ChIP_HEK293T_Human3.18245411
14* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.16240146
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.14217987
16FOXM1_23109430_ChIP-Seq_U2OS_Human3.12656995
17* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.99366886
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.88367978
19XRN2_22483619_ChIP-Seq_HELA_Human2.73551963
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.59560018
21* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.58476908
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.57888679
23* VDR_23849224_ChIP-Seq_CD4+_Human2.55953919
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.48474457
25DCP1A_22483619_ChIP-Seq_HELA_Human2.33923545
26* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.29739607
27TTF2_22483619_ChIP-Seq_HELA_Human2.29415010
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.29376471
29E2F1_18555785_ChIP-Seq_MESCs_Mouse2.22994964
30FOXP3_21729870_ChIP-Seq_TREG_Human2.21019861
31* ELK1_19687146_ChIP-ChIP_HELA_Human2.06661655
32* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.00005063
33MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.96281470
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.95148576
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.94399538
36GABP_19822575_ChIP-Seq_HepG2_Human1.90155580
37YY1_21170310_ChIP-Seq_MESCs_Mouse1.82932459
38SRF_21415370_ChIP-Seq_HL-1_Mouse1.79556161
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.77052465
40* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.75633930
41* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.72752411
42ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.70454765
43E2F1_21310950_ChIP-Seq_MCF-7_Human1.68412759
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.65577463
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.62671280
46* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.61095124
47NANOG_18555785_ChIP-Seq_MESCs_Mouse1.60783195
48AR_21909140_ChIP-Seq_LNCAP_Human1.58974694
49HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.56257002
50EWS_26573619_Chip-Seq_HEK293_Human1.51651677
51* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.47297409
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47082356
53YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46741268
54VDR_22108803_ChIP-Seq_LS180_Human1.44908485
55* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.42597940
56POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.41837043
57MYC_18940864_ChIP-ChIP_HL60_Human1.40983597
58ZFX_18555785_ChIP-Seq_MESCs_Mouse1.38592785
59ERG_20887958_ChIP-Seq_HPC-7_Mouse1.38021045
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.35817069
61KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.35434581
62* ELK1_22589737_ChIP-Seq_MCF10A_Human1.33833569
63PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.33420213
64FUS_26573619_Chip-Seq_HEK293_Human1.32634436
65CIITA_25753668_ChIP-Seq_RAJI_Human1.31451609
66HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.30932569
67CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.30068315
68FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.29083237
69NANOG_16153702_ChIP-ChIP_HESCs_Human1.28056446
70TP63_19390658_ChIP-ChIP_HaCaT_Human1.27670166
71ZNF274_21170338_ChIP-Seq_K562_Hela1.24498587
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23528490
73POU5F1_16153702_ChIP-ChIP_HESCs_Human1.22625035
74RBPJ_22232070_ChIP-Seq_NCS_Mouse1.22264509
75ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.20074136
76KDM5A_27292631_Chip-Seq_BREAST_Human1.18288959
77SOX2_16153702_ChIP-ChIP_HESCs_Human1.15745817
78CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.13668236
79SOX2_18555785_ChIP-Seq_MESCs_Mouse1.12046996
80SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.11372980
81PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10150067
82CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.07659236
83FLI1_27457419_Chip-Seq_LIVER_Mouse1.03920837
84E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01450550
85TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.93685808
86BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92796926
87SPI1_23547873_ChIP-Seq_NB4_Human0.92411959
88CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.92395964
89IRF1_19129219_ChIP-ChIP_H3396_Human0.90279733
90CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.88495150
91GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88060632
92* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.86774236
93DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.85788586
94KLF4_18555785_ChIP-Seq_MESCs_Mouse0.84147638
95STAT3_1855785_ChIP-Seq_MESCs_Mouse0.83622051
96CTCF_18555785_ChIP-Seq_MESCs_Mouse0.83038034
97MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.82656714
98SALL1_21062744_ChIP-ChIP_HESCs_Human0.81449286
99IGF1R_20145208_ChIP-Seq_DFB_Human0.81133740
100TP53_22573176_ChIP-Seq_HFKS_Human0.79676251
101SRY_22984422_ChIP-ChIP_TESTIS_Rat0.78208943
102POU3F2_20337985_ChIP-ChIP_501MEL_Human0.77398048
103* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76996747
104HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.76849490
105OCT4_18692474_ChIP-Seq_MEFs_Mouse0.75343865
106ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.75278825
107DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.74836648
108NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.74662667
109PCGF2_27294783_Chip-Seq_ESCs_Mouse0.74504432
110* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.73603842
111SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.73366395
112TFEB_21752829_ChIP-Seq_HELA_Human0.72945462
113TAF15_26573619_Chip-Seq_HEK293_Human0.72540240
114GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.72081676
115SOX17_20123909_ChIP-Seq_XEN_Mouse0.71625098
116EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.70375293
117POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.70046452
118KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.69813846
119IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.69026696
120ELF5_23300383_ChIP-Seq_T47D_Human0.68444160
121TCF3_18692474_ChIP-Seq_MEFs_Mouse0.67795119
122ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.67684725
123SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.66844101
124RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.66253387
125P300_19829295_ChIP-Seq_ESCs_Human0.65919160
126* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.64374474
127VDR_21846776_ChIP-Seq_THP-1_Human0.63639848

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.27794723
2MP0009379_abnormal_foot_pigmentation5.04579665
3MP0004957_abnormal_blastocyst_morpholog4.11654276
4MP0010094_abnormal_chromosome_stability3.89593210
5MP0003111_abnormal_nucleus_morphology3.70671195
6MP0003077_abnormal_cell_cycle3.53854672
7MP0008057_abnormal_DNA_replication3.23183815
8MP0008058_abnormal_DNA_repair3.17868139
9MP0008932_abnormal_embryonic_tissue2.86069547
10MP0008007_abnormal_cellular_replicative2.65827647
11MP0006292_abnormal_olfactory_placode2.46619714
12MP0006072_abnormal_retinal_apoptosis2.28283433
13MP0009697_abnormal_copulation2.22072965
14MP0003786_premature_aging2.18197585
15MP0002102_abnormal_ear_morphology2.07519932
16MP0003718_maternal_effect1.98148384
17MP0003136_yellow_coat_color1.94677821
18MP0002396_abnormal_hematopoietic_system1.86476122
19MP0003315_abnormal_perineum_morphology1.78401575
20MP0002132_abnormal_respiratory_system1.77554961
21MP0000490_abnormal_crypts_of1.74518716
22MP0003123_paternal_imprinting1.70312318
23MP0000350_abnormal_cell_proliferation1.62554794
24MP0002938_white_spotting1.53561936
25MP0005174_abnormal_tail_pigmentation1.52513111
26MP0010030_abnormal_orbit_morphology1.47919178
27MP0009333_abnormal_splenocyte_physiolog1.47541972
28MP0008877_abnormal_DNA_methylation1.46970548
29MP0003186_abnormal_redox_activity1.45819234
30MP0005084_abnormal_gallbladder_morpholo1.45525853
31MP0001730_embryonic_growth_arrest1.41325493
32MP0000566_synostosis1.40850153
33MP0002736_abnormal_nociception_after1.31297518
34MP0003763_abnormal_thymus_physiology1.27080812
35MP0000313_abnormal_cell_death1.25938744
36MP0002638_abnormal_pupillary_reflex1.25145785
37MP0002837_dystrophic_cardiac_calcinosis1.22348592
38MP0004381_abnormal_hair_follicle1.22143788
39MP0002210_abnormal_sex_determination1.21160738
40MP0004142_abnormal_muscle_tone1.20499531
41MP0002277_abnormal_respiratory_mucosa1.19239135
42MP0002095_abnormal_skin_pigmentation1.18583437
43MP0000049_abnormal_middle_ear1.18500165
44MP0002163_abnormal_gland_morphology1.18115947
45MP0005253_abnormal_eye_physiology1.16250799
46MP0002019_abnormal_tumor_incidence1.14718675
47MP0005075_abnormal_melanosome_morpholog1.14651587
48MP0000631_abnormal_neuroendocrine_gland1.14194429
49MP0001853_heart_inflammation1.13571899
50MP0001697_abnormal_embryo_size1.13061724
51MP0001485_abnormal_pinna_reflex1.12577913
52MP0003941_abnormal_skin_development1.08813962
53MP0005394_taste/olfaction_phenotype1.07555441
54MP0005499_abnormal_olfactory_system1.07555441
55MP0004133_heterotaxia1.06111914
56MP0003938_abnormal_ear_development1.04812591
57MP0001188_hyperpigmentation1.04571673
58MP0003567_abnormal_fetal_cardiomyocyte1.04207318
59MP0001764_abnormal_homeostasis1.03452474
60MP0002080_prenatal_lethality1.02838690
61MP0008789_abnormal_olfactory_epithelium1.02049217
62MP0002085_abnormal_embryonic_tissue1.01352274
63MP0001145_abnormal_male_reproductive1.00482113
64MP0000703_abnormal_thymus_morphology1.00426298
65MP0002234_abnormal_pharynx_morphology0.99568306
66MP0001293_anophthalmia0.99382426
67MP0003880_abnormal_central_pattern0.99326954
68MP0001986_abnormal_taste_sensitivity0.98976776
69MP0003195_calcinosis0.97947730
70MP0005380_embryogenesis_phenotype0.97627205
71MP0001672_abnormal_embryogenesis/_devel0.97627205
72MP0001984_abnormal_olfaction0.97352019
73MP0000372_irregular_coat_pigmentation0.96019410
74MP0002398_abnormal_bone_marrow0.94168837
75MP0001529_abnormal_vocalization0.93658877
76MP0005551_abnormal_eye_electrophysiolog0.92984312
77MP0002233_abnormal_nose_morphology0.92771542
78MP0002722_abnormal_immune_system0.91835630
79MP0008995_early_reproductive_senescence0.91305396
80MP0002160_abnormal_reproductive_system0.90397202
81MP0000653_abnormal_sex_gland0.89221004
82MP0005409_darkened_coat_color0.88639473
83MP0008872_abnormal_physiological_respon0.88089399
84MP0000858_altered_metastatic_potential0.86697061
85MP0001929_abnormal_gametogenesis0.85897188
86MP0006054_spinal_hemorrhage0.85831848
87MP0004808_abnormal_hematopoietic_stem0.85471589
88MP0005397_hematopoietic_system_phenotyp0.85082748
89MP0001545_abnormal_hematopoietic_system0.85082748
90MP0002751_abnormal_autonomic_nervous0.84890268
91MP0001286_abnormal_eye_development0.84778287
92MP0003890_abnormal_embryonic-extraembry0.84353171
93MP0006036_abnormal_mitochondrial_physio0.84031174
94MP0001905_abnormal_dopamine_level0.83962700
95MP0000689_abnormal_spleen_morphology0.83806944
96MP0005389_reproductive_system_phenotype0.82089138
97MP0003937_abnormal_limbs/digits/tail_de0.81879694
98MP0003121_genomic_imprinting0.81764501
99MP0001119_abnormal_female_reproductive0.80635015
100MP0000647_abnormal_sebaceous_gland0.79970941
101MP0002111_abnormal_tail_morphology0.78437920
102MP0002429_abnormal_blood_cell0.78388610
103MP0003119_abnormal_digestive_system0.78363605
104MP0003984_embryonic_growth_retardation0.78000959
105MP0002148_abnormal_hypersensitivity_rea0.77862241
106MP0003011_delayed_dark_adaptation0.77804046
107MP0002697_abnormal_eye_size0.77224140
108MP0001919_abnormal_reproductive_system0.77193195
109MP0002090_abnormal_vision0.77143475
110MP0004147_increased_porphyrin_level0.76817731
111MP0002088_abnormal_embryonic_growth/wei0.76020967
112MP0005391_vision/eye_phenotype0.75962027
113MP0005671_abnormal_response_to0.75781731
114MP0006035_abnormal_mitochondrial_morpho0.74712730
115MP0004215_abnormal_myocardial_fiber0.74631537
116MP0002282_abnormal_trachea_morphology0.74344907
117MP0008875_abnormal_xenobiotic_pharmacok0.73938013
118MP0005408_hypopigmentation0.72378893
119MP0002084_abnormal_developmental_patter0.72036763
120MP0005646_abnormal_pituitary_gland0.71908212
121MP0003698_abnormal_male_reproductive0.69418909
122MP0005332_abnormal_amino_acid0.68045066
123MP0000716_abnormal_immune_system0.67878718
124MP0003137_abnormal_impulse_conducting0.67493949
125MP0002249_abnormal_larynx_morphology0.67356731
126MP0001727_abnormal_embryo_implantation0.66324453
127MP0000516_abnormal_urinary_system0.65891849
128MP0003806_abnormal_nucleotide_metabolis0.65798921
129MP0003724_increased_susceptibility_to0.65200635
130MP0000613_abnormal_salivary_gland0.63615740
131MP0009785_altered_susceptibility_to0.63464264
132MP0000015_abnormal_ear_pigmentation0.61328324
133MP0002420_abnormal_adaptive_immunity0.59769886
134MP0002086_abnormal_extraembryonic_tissu0.59688307
135MP0000358_abnormal_cell_content/0.59465854

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)7.02030635
2Reticulocytopenia (HP:0001896)6.86515303
3Abnormal number of erythroid precursors (HP:0012131)6.61529077
4Macrocytic anemia (HP:0001972)5.05356803
5Pallor (HP:0000980)4.70936854
6Birth length less than 3rd percentile (HP:0003561)3.95528952
7Cerebral edema (HP:0002181)3.86702654
8Increased hepatocellular lipid droplets (HP:0006565)3.62360924
9Aplastic anemia (HP:0001915)3.58124428
10Mitochondrial inheritance (HP:0001427)3.54425490
11Oral leukoplakia (HP:0002745)3.53692115
12Aplasia/Hypoplasia of the sacrum (HP:0008517)3.53422390
13Breast hypoplasia (HP:0003187)3.45180989
14Acute necrotizing encephalopathy (HP:0006965)3.39593709
15Hepatocellular necrosis (HP:0001404)3.31255823
16Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.22961265
17Decreased activity of mitochondrial respiratory chain (HP:0008972)3.21820050
18Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.21820050
19Lipid accumulation in hepatocytes (HP:0006561)3.06367483
20Increased CSF lactate (HP:0002490)3.05519016
21Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.05033595
22Chromsome breakage (HP:0040012)3.03603414
23Exertional dyspnea (HP:0002875)3.03355351
24Leukodystrophy (HP:0002415)2.96113050
25Abnormal mitochondria in muscle tissue (HP:0008316)2.96045965
26Chromosomal breakage induced by crosslinking agents (HP:0003221)2.91463711
27Rough bone trabeculation (HP:0100670)2.89810238
28Abnormality of the preputium (HP:0100587)2.86773888
29Colon cancer (HP:0003003)2.81210072
30Triphalangeal thumb (HP:0001199)2.79390438
313-Methylglutaconic aciduria (HP:0003535)2.77924573
32Renal Fanconi syndrome (HP:0001994)2.76329448
33Hepatic necrosis (HP:0002605)2.74011542
34Patellar aplasia (HP:0006443)2.73569193
35Meckel diverticulum (HP:0002245)2.73215390
36Absent thumb (HP:0009777)2.72827875
37Optic disc pallor (HP:0000543)2.72174717
3811 pairs of ribs (HP:0000878)2.68247316
39Progressive macrocephaly (HP:0004481)2.68136116
40Increased serum lactate (HP:0002151)2.60761482
41Aplasia/Hypoplasia of the patella (HP:0006498)2.59761018
42Abnormality of the ileum (HP:0001549)2.59382216
43Type I transferrin isoform profile (HP:0003642)2.56231895
44Methylmalonic acidemia (HP:0002912)2.54688316
45Acute encephalopathy (HP:0006846)2.54155563
46Carpal bone hypoplasia (HP:0001498)2.48540042
47Abnormality of renal resorption (HP:0011038)2.46602131
48Abnormality of the heme biosynthetic pathway (HP:0010472)2.44617196
49Abnormality of the labia minora (HP:0012880)2.44543605
50Premature graying of hair (HP:0002216)2.42714168
51Septo-optic dysplasia (HP:0100842)2.42156206
52Abnormal hemoglobin (HP:0011902)2.40438732
53Horseshoe kidney (HP:0000085)2.39027022
54Respiratory difficulties (HP:0002880)2.36605121
55Congenital, generalized hypertrichosis (HP:0004540)2.35779525
56Abnormality of chromosome stability (HP:0003220)2.35764922
57Increased intramyocellular lipid droplets (HP:0012240)2.35226029
58Lethargy (HP:0001254)2.34138798
59Duplicated collecting system (HP:0000081)2.31496160
60Absent radius (HP:0003974)2.31201890
61Aplasia/Hypoplasia of the uvula (HP:0010293)2.29799273
62Cerebral hypomyelination (HP:0006808)2.28888295
63Abnormality of methionine metabolism (HP:0010901)2.28692860
64Depressed nasal ridge (HP:0000457)2.27675263
65Cleft eyelid (HP:0000625)2.27090182
66Trismus (HP:0000211)2.25193685
67Methylmalonic aciduria (HP:0012120)2.24581737
68Pancytopenia (HP:0001876)2.20264251
69Exercise intolerance (HP:0003546)2.17698201
70Abnormality of reticulocytes (HP:0004312)2.16866949
71Aplasia involving forearm bones (HP:0009822)2.16038991
72Absent forearm bone (HP:0003953)2.16038991
73Hypoplasia of the radius (HP:0002984)2.13745083
74Abnormal trabecular bone morphology (HP:0100671)2.13159024
75Microretrognathia (HP:0000308)2.13093022
76Abnormality of placental membranes (HP:0011409)2.12130842
77Amniotic constriction ring (HP:0009775)2.12130842
78Abnormal number of incisors (HP:0011064)2.10283530
79Pancreatic fibrosis (HP:0100732)2.10153642
80Microvesicular hepatic steatosis (HP:0001414)2.09463212
81Myelodysplasia (HP:0002863)2.09166866
82Glycosuria (HP:0003076)2.08196054
83Abnormality of urine glucose concentration (HP:0011016)2.08196054
84Megaloblastic anemia (HP:0001889)2.07107414
85Bone marrow hypocellularity (HP:0005528)2.06655300
86Secondary amenorrhea (HP:0000869)2.06218963
87Degeneration of anterior horn cells (HP:0002398)2.05877569
88Abnormality of the anterior horn cell (HP:0006802)2.05877569
89CNS demyelination (HP:0007305)2.04579696
90Abnormality of the renal collecting system (HP:0004742)2.02396775
91Abnormality of serum amino acid levels (HP:0003112)2.02174935
92Respiratory failure (HP:0002878)2.01712756
93X-linked dominant inheritance (HP:0001423)2.01200447
94Small intestinal stenosis (HP:0012848)2.01019780
95Duodenal stenosis (HP:0100867)2.01019780
96Aplasia/hypoplasia of the uterus (HP:0008684)2.00967801
97Hyperglycinemia (HP:0002154)1.99208226
98Abnormality of aspartate family amino acid metabolism (HP:0010899)1.98034261
99Sparse eyelashes (HP:0000653)1.97803121
100Abnormal lung lobation (HP:0002101)1.97336145
101Thrombocytosis (HP:0001894)1.96998735
102Supernumerary spleens (HP:0009799)1.96904731
103True hermaphroditism (HP:0010459)1.95537167
104Abnormality of midbrain morphology (HP:0002418)1.95229259
105Molar tooth sign on MRI (HP:0002419)1.95229259
106Selective tooth agenesis (HP:0001592)1.94362299
107Tracheoesophageal fistula (HP:0002575)1.93106000
108Abnormality of the axillary hair (HP:0100134)1.93018363
109Abnormality of secondary sexual hair (HP:0009888)1.93018363
110Generalized aminoaciduria (HP:0002909)1.92869576
111Cellular immunodeficiency (HP:0005374)1.92083649
112Hyperphosphaturia (HP:0003109)1.90861896
113Absent septum pellucidum (HP:0001331)1.90477057
114Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.86540218
115Abnormal protein N-linked glycosylation (HP:0012347)1.86540218
116Abnormal protein glycosylation (HP:0012346)1.86540218
117Abnormal glycosylation (HP:0012345)1.86540218
118Muscle fiber atrophy (HP:0100295)1.84974118
119Multiple enchondromatosis (HP:0005701)1.84718713
120Stenosis of the external auditory canal (HP:0000402)1.83019473
121Abnormality of the duodenum (HP:0002246)1.82841929
122Abnormality of alanine metabolism (HP:0010916)1.82095350
123Hyperalaninemia (HP:0003348)1.82095350
124Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.82095350
125Concave nail (HP:0001598)1.81096083
126Lactic acidosis (HP:0003128)1.80867102
127Increased muscle lipid content (HP:0009058)1.79760587
128Thick lower lip vermilion (HP:0000179)1.77026770
129Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.76889816
130Neoplasm of the pancreas (HP:0002894)1.76860950
131Duplication of thumb phalanx (HP:0009942)1.75559063
132Hypoplasia of the pons (HP:0012110)1.73343499
133Atresia of the external auditory canal (HP:0000413)1.73336100
134Reduced antithrombin III activity (HP:0001976)1.73138106
135Clubbing of toes (HP:0100760)1.73128490
136Asplenia (HP:0001746)1.72001231
137Increased serum pyruvate (HP:0003542)1.71476916
138Abnormality of glycolysis (HP:0004366)1.71476916
139Pancreatic cysts (HP:0001737)1.71195348
140Sclerocornea (HP:0000647)1.69946286
141Abnormality of the septum pellucidum (HP:0007375)1.69734526
142Abnormality of the pons (HP:0007361)1.67405821
143Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.66913454

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.55969084
2BUB14.55663550
3WEE14.01029672
4STK163.75449492
5NME23.75231087
6TLK13.31688614
7EIF2AK13.28117966
8SRPK13.18752446
9VRK13.01490708
10CDC72.79365071
11PLK42.34630888
12ACVR1B2.14590320
13EIF2AK32.10142583
14DYRK32.05574689
15PBK1.94790593
16MKNK11.94122040
17TESK21.89865529
18MKNK21.80891197
19BRSK21.75758357
20WNK31.69075668
21PLK11.65466009
22NME11.61532906
23TTK1.59006928
24PIM21.58751952
25TAF11.57040054
26AURKB1.52891031
27NEK21.49779141
28CDK71.47935724
29TRIM281.43274520
30RPS6KB21.32155312
31MAP4K21.29395275
32CDK81.26438956
33AURKA1.24988217
34MST41.23652166
35ATR1.18820652
36IRAK31.18333033
37CHEK21.17420587
38EIF2AK21.17416744
39RPS6KA41.16184102
40DYRK21.14549507
41TSSK61.08092233
42KDR1.07006164
43PLK31.03846796
44IRAK41.03311476
45ZAK1.00953782
46BCKDK0.94980810
47CCNB10.93021243
48PASK0.92897421
49BRSK10.91378727
50TGFBR10.90667276
51CDK190.90566107
52BLK0.84055441
53GRK10.83010452
54BRAF0.82539359
55CSNK2A10.81231858
56PDK20.80952227
57RPS6KA50.77819789
58CSNK2A20.77696702
59TNIK0.75533816
60TEC0.73563611
61STK40.73496697
62MAP3K80.73377046
63ABL20.73230550
64CHEK10.73222029
65LRRK20.71592765
66INSRR0.68893602
67BMPR1B0.68462581
68CSNK1G10.68236381
69CDK40.67830386
70OXSR10.65761180
71LIMK10.64512409
72PAK40.64325941
73PLK20.63606713
74PIM10.62962368
75BCR0.62016408
76MAP3K110.60126020
77NLK0.58916054
78PAK10.58571154
79CSNK1G20.57698560
80CLK10.57489354
81MAP3K40.56816506
82ATM0.56699969
83YES10.56236215
84MAP2K70.55969222
85MYLK0.53718511
86ERBB30.51207831
87PRKCI0.50082815
88ILK0.49730020
89STK100.49261089
90TESK10.48582565
91CDK20.48406806
92DAPK10.47482035
93PRKCG0.45344622
94IKBKB0.44815060
95CSNK1E0.43695206
96IRAK20.43552813
97NEK10.43308648
98TXK0.42186514
99EPHA20.41587032
100STK38L0.40505038
101MAP4K10.40207348
102BTK0.39752130
103LYN0.38823658
104CDK10.38388088
105MUSK0.37772222
106STK30.37347134
107CSNK1A1L0.37284477
108BRD40.36028754
109WNK40.33655627
110TIE10.32765507
111ALK0.32585645
112ADRBK20.32043201
113CSNK1A10.31613860
114MAPKAPK30.31219933
115FGFR10.31191076
116MELK0.30747984
117ERBB40.29854518
118MAP3K120.29816080
119KIT0.28973707
120FRK0.27275616
121IRAK10.26603718
122CDK30.25913233
123SCYL20.25738271
124CSNK1G30.25205434
125PNCK0.24561768
126CASK0.24048605
127NUAK10.23715874
128DAPK30.21218946
129MAPK40.21030800
130NEK90.20125771
131MAPKAPK50.19482786
132UHMK10.16974651

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.22690109
2DNA replication_Homo sapiens_hsa030304.32233631
3RNA polymerase_Homo sapiens_hsa030203.88468545
4Proteasome_Homo sapiens_hsa030503.63068833
5Mismatch repair_Homo sapiens_hsa034303.60322914
6* Spliceosome_Homo sapiens_hsa030403.18232271
7Homologous recombination_Homo sapiens_hsa034403.06728520
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.98125201
9Pyrimidine metabolism_Homo sapiens_hsa002402.75735307
10Nucleotide excision repair_Homo sapiens_hsa034202.65883198
11Base excision repair_Homo sapiens_hsa034102.51824046
12RNA transport_Homo sapiens_hsa030132.30581501
13Oxidative phosphorylation_Homo sapiens_hsa001902.27459359
14Fanconi anemia pathway_Homo sapiens_hsa034602.25624779
15Protein export_Homo sapiens_hsa030602.16493007
16Parkinsons disease_Homo sapiens_hsa050122.13098095
17Basal transcription factors_Homo sapiens_hsa030222.04284748
18Cell cycle_Homo sapiens_hsa041101.96202603
19Huntingtons disease_Homo sapiens_hsa050161.85041056
20One carbon pool by folate_Homo sapiens_hsa006701.84535730
21RNA degradation_Homo sapiens_hsa030181.82273784
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.72517549
23Non-homologous end-joining_Homo sapiens_hsa034501.67707700
24Purine metabolism_Homo sapiens_hsa002301.46154603
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.41163238
26Alzheimers disease_Homo sapiens_hsa050101.34202724
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.31806562
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.28212905
29p53 signaling pathway_Homo sapiens_hsa041151.23577326
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.16517876
31Propanoate metabolism_Homo sapiens_hsa006401.11884611
32Systemic lupus erythematosus_Homo sapiens_hsa053221.10982970
33Pyruvate metabolism_Homo sapiens_hsa006201.10445557
34mRNA surveillance pathway_Homo sapiens_hsa030151.07473915
35Epstein-Barr virus infection_Homo sapiens_hsa051691.02753599
36Sulfur relay system_Homo sapiens_hsa041220.93750297
37Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.93158458
38Folate biosynthesis_Homo sapiens_hsa007900.92476185
39Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.89348827
40Fatty acid elongation_Homo sapiens_hsa000620.85222273
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.83371546
42Herpes simplex infection_Homo sapiens_hsa051680.81665798
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80958840
44Steroid biosynthesis_Homo sapiens_hsa001000.80016118
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.79284934
46Selenocompound metabolism_Homo sapiens_hsa004500.75394043
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69666015
48Glutathione metabolism_Homo sapiens_hsa004800.68860245
49Primary immunodeficiency_Homo sapiens_hsa053400.60527499
50Butanoate metabolism_Homo sapiens_hsa006500.60086537
51Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.56911151
52Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56505363
53Cyanoamino acid metabolism_Homo sapiens_hsa004600.56461959
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54292254
55Sulfur metabolism_Homo sapiens_hsa009200.54095777
56Arachidonic acid metabolism_Homo sapiens_hsa005900.53204297
57Cardiac muscle contraction_Homo sapiens_hsa042600.52929715
58Peroxisome_Homo sapiens_hsa041460.52343323
59Antigen processing and presentation_Homo sapiens_hsa046120.51826948
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50974358
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48523133
622-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48050482
63Carbon metabolism_Homo sapiens_hsa012000.47646544
64Maturity onset diabetes of the young_Homo sapiens_hsa049500.47625804
65Oocyte meiosis_Homo sapiens_hsa041140.47477683
66Pentose phosphate pathway_Homo sapiens_hsa000300.47187020
67Vitamin digestion and absorption_Homo sapiens_hsa049770.46984388
68Collecting duct acid secretion_Homo sapiens_hsa049660.45978253
69Viral carcinogenesis_Homo sapiens_hsa052030.45940538
70Chemical carcinogenesis_Homo sapiens_hsa052040.45272729
71Graft-versus-host disease_Homo sapiens_hsa053320.44911410
72Hematopoietic cell lineage_Homo sapiens_hsa046400.44403600
73Allograft rejection_Homo sapiens_hsa053300.44281204
74Drug metabolism - other enzymes_Homo sapiens_hsa009830.44188588
75Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43938656
76Tryptophan metabolism_Homo sapiens_hsa003800.43121368
77Metabolic pathways_Homo sapiens_hsa011000.42944797
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42843044
79Asthma_Homo sapiens_hsa053100.42007256
80HTLV-I infection_Homo sapiens_hsa051660.41924245
81Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.39885650
82Nitrogen metabolism_Homo sapiens_hsa009100.39876615
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.39794110
84Caffeine metabolism_Homo sapiens_hsa002320.38669855
85N-Glycan biosynthesis_Homo sapiens_hsa005100.37530008
86Alcoholism_Homo sapiens_hsa050340.35713584
87Autoimmune thyroid disease_Homo sapiens_hsa053200.34911958
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32488234
89Intestinal immune network for IgA production_Homo sapiens_hsa046720.32382496
90Measles_Homo sapiens_hsa051620.32253983
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32193709
92Retinol metabolism_Homo sapiens_hsa008300.32087625
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31578825
94beta-Alanine metabolism_Homo sapiens_hsa004100.30949474
95Tyrosine metabolism_Homo sapiens_hsa003500.30405726
96Legionellosis_Homo sapiens_hsa051340.30010494
97Linoleic acid metabolism_Homo sapiens_hsa005910.29189736
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.29151213
99Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.28224043
100NF-kappa B signaling pathway_Homo sapiens_hsa040640.26575318
101Fatty acid degradation_Homo sapiens_hsa000710.24898988
102Basal cell carcinoma_Homo sapiens_hsa052170.24392022
103Regulation of autophagy_Homo sapiens_hsa041400.24203587
104Primary bile acid biosynthesis_Homo sapiens_hsa001200.24135909
105RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.23583918
106NOD-like receptor signaling pathway_Homo sapiens_hsa046210.23345489
107Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.22710104
108Olfactory transduction_Homo sapiens_hsa047400.21830921
109Thyroid cancer_Homo sapiens_hsa052160.21790642
110Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.21228973
111Apoptosis_Homo sapiens_hsa042100.20746031
112Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.20463432
113TGF-beta signaling pathway_Homo sapiens_hsa043500.20372691
114Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.19851819
115Small cell lung cancer_Homo sapiens_hsa052220.19682778
116Steroid hormone biosynthesis_Homo sapiens_hsa001400.19597236
117Fatty acid metabolism_Homo sapiens_hsa012120.18003465
118Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.17696033
119Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.16601211
120Sphingolipid metabolism_Homo sapiens_hsa006000.16230589
121Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.14784276
122Hepatitis B_Homo sapiens_hsa051610.14775554
123Fat digestion and absorption_Homo sapiens_hsa049750.14145175
124Ether lipid metabolism_Homo sapiens_hsa005650.13431907
125Vitamin B6 metabolism_Homo sapiens_hsa007500.13158553
126MicroRNAs in cancer_Homo sapiens_hsa052060.12905657
127Nicotine addiction_Homo sapiens_hsa050330.11879832
128Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.09789006
129Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.09556458
130Other glycan degradation_Homo sapiens_hsa005110.09555298
131Influenza A_Homo sapiens_hsa051640.08995208
132Renin-angiotensin system_Homo sapiens_hsa046140.08968276
133Pathways in cancer_Homo sapiens_hsa052000.08885264
134Shigellosis_Homo sapiens_hsa051310.08777926
135Hedgehog signaling pathway_Homo sapiens_hsa043400.08478018
136alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.06984302
137Phototransduction_Homo sapiens_hsa047440.06394905
138Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.05950280
139Jak-STAT signaling pathway_Homo sapiens_hsa046300.05599149
140Biosynthesis of amino acids_Homo sapiens_hsa012300.04127456
141Arginine and proline metabolism_Homo sapiens_hsa003300.03828966
142Wnt signaling pathway_Homo sapiens_hsa043100.03604785
143Colorectal cancer_Homo sapiens_hsa052100.03422592

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