SNRPGP15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)9.85725768
2maturation of 5.8S rRNA (GO:0000460)9.58583482
3positive regulation of signal transduction by p53 class mediator (GO:1901798)9.25396800
4secretory granule organization (GO:0033363)8.84761572
5regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)8.02783768
6platelet formation (GO:0030220)7.54043379
7regulation of mitochondrial translation (GO:0070129)7.00980853
8cytochrome complex assembly (GO:0017004)6.62401505
9negative regulation of signal transduction by p53 class mediator (GO:1901797)5.81567951
10negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage (GO:1902230)5.52350130
11ribosomal small subunit biogenesis (GO:0042274)5.46832669
12regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043516)5.43119131
13fusion of sperm to egg plasma membrane (GO:0007342)5.42030308
14negative regulation of translational initiation (GO:0045947)5.32841971
15negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)5.30294122
16positive regulation of macrophage differentiation (GO:0045651)5.28551779
17myeloid cell development (GO:0061515)5.08785816
18pseudouridine synthesis (GO:0001522)4.78550131
19piRNA metabolic process (GO:0034587)4.59329649
20ribosomal small subunit assembly (GO:0000028)4.53205294
21T cell apoptotic process (GO:0070231)4.43420834
22regulation of intrinsic apoptotic signaling pathway in response to DNA damage (GO:1902229)4.40383612
23plasma membrane fusion (GO:0045026)4.39829777
24positive regulation of fat cell differentiation (GO:0045600)4.33820289
25production of molecular mediator involved in inflammatory response (GO:0002532)4.16336310
26protein complex biogenesis (GO:0070271)4.14637419
27fibril organization (GO:0097435)4.02951249
28regulation of necrotic cell death (GO:0010939)3.98882054
29regulation of translation in response to stress (GO:0043555)3.97627508
30response to food (GO:0032094)3.96197981
31negative regulation of membrane potential (GO:0045837)3.95334311
32establishment of protein localization to mitochondrial membrane (GO:0090151)3.92793375
33positive regulation of mast cell activation involved in immune response (GO:0033008)3.92215724
34positive regulation of mast cell degranulation (GO:0043306)3.92215724
35lymphocyte apoptotic process (GO:0070227)3.90238235
36protein kinase B signaling (GO:0043491)3.89302176
37negative regulation of chemokine production (GO:0032682)3.81022991
38regulation of epidermal growth factor-activated receptor activity (GO:0007176)3.80329322
39regulation of B cell differentiation (GO:0045577)3.77879068
40mitochondrial respiratory chain complex assembly (GO:0033108)3.77110070
41pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.74538373
42viral transcription (GO:0019083)3.60993915
43cellular protein catabolic process (GO:0044257)3.56007807
44regulation of necroptotic process (GO:0060544)3.52292788
45lamellipodium assembly (GO:0030032)3.49777151
46regulation of signal transduction by p53 class mediator (GO:1901796)3.48364459
47translational termination (GO:0006415)3.44812592
48necroptotic process (GO:0070266)3.43746356
49regulation of memory T cell differentiation (GO:0043380)3.42351314
50erythrocyte maturation (GO:0043249)3.35769781
51respiratory chain complex IV assembly (GO:0008535)3.35083555
52glucose 6-phosphate metabolic process (GO:0051156)3.30317460
53positive regulation of translation (GO:0045727)3.27082796
54regulation of translational initiation (GO:0006446)3.25167605
55lamellipodium organization (GO:0097581)3.15426533
56positive regulation of mast cell activation (GO:0033005)3.08493679
57pyrimidine nucleotide catabolic process (GO:0006244)3.07917145
58ubiquinone biosynthetic process (GO:0006744)3.07237155
59rRNA catabolic process (GO:0016075)3.05940571
60positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.05478621
61sequestering of extracellular ligand from receptor (GO:0035581)3.05454842
62positive regulation of growth hormone secretion (GO:0060124)3.02085495
63positive regulation of response to DNA damage stimulus (GO:2001022)3.01742646
64oligodendrocyte development (GO:0014003)3.00761414
65regulation of macrophage differentiation (GO:0045649)3.00031070
66SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.95418294
67multicellular organism reproduction (GO:0032504)2.92440282
68cotranslational protein targeting to membrane (GO:0006613)2.92409378
69negative regulation of response to DNA damage stimulus (GO:2001021)2.92117774
70protein targeting to ER (GO:0045047)2.84001457
71regulation of nucleobase-containing compound transport (GO:0032239)2.82790902
72leukocyte apoptotic process (GO:0071887)2.82061367
73regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.80752021
74ubiquinone metabolic process (GO:0006743)2.75146909
75nucleoside transmembrane transport (GO:1901642)2.74155105
76positive regulation of T cell apoptotic process (GO:0070234)2.71695812
77DNA replication-dependent nucleosome assembly (GO:0006335)2.71435589
78DNA replication-dependent nucleosome organization (GO:0034723)2.71435589
79detection of light stimulus involved in visual perception (GO:0050908)2.70632865
80detection of light stimulus involved in sensory perception (GO:0050962)2.70632865
81positive regulation of mitochondrial membrane permeability (GO:0035794)2.69982863
82establishment of protein localization to endoplasmic reticulum (GO:0072599)2.69378057
83neural tube formation (GO:0001841)2.68517279
84positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.64823587
85protein localization to endoplasmic reticulum (GO:0070972)2.64373595
86translational initiation (GO:0006413)2.63099827
87rRNA modification (GO:0000154)2.61258812
88protein insertion into membrane (GO:0051205)2.61055500
89leukotriene biosynthetic process (GO:0019370)2.60539980
90translational elongation (GO:0006414)2.60337002
91necrotic cell death (GO:0070265)2.58760278
92detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.56855948
93cellular protein complex disassembly (GO:0043624)2.56478882
94RNA localization (GO:0006403)15.9024397
95signal complex assembly (GO:0007172)13.4935523
96negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 11.9671413
97positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)11.7453904
98megakaryocyte development (GO:0035855)10.5845393
99positive regulation of translational initiation (GO:0045948)10.3479850
100regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 10.0002963

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human7.93015042
2TP53_16413492_ChIP-PET_HCT116_Human3.53764851
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.32814115
4VDR_22108803_ChIP-Seq_LS180_Human3.09075317
5EZH2_22144423_ChIP-Seq_EOC_Human2.90914689
6EGR1_19032775_ChIP-ChIP_M12_Human2.74413675
7AR_21572438_ChIP-Seq_LNCaP_Human2.73633617
8RNF2_27304074_Chip-Seq_NSC_Mouse2.43275329
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.22429934
10CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.20259973
11RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.13625512
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.06742448
13SRY_22984422_ChIP-ChIP_TESTIS_Rat2.05102152
14FLI1_27457419_Chip-Seq_LIVER_Mouse1.99340159
15GBX2_23144817_ChIP-Seq_PC3_Human1.96248499
16TP63_19390658_ChIP-ChIP_HaCaT_Human1.95001693
17CBX2_27304074_Chip-Seq_ESCs_Mouse1.93329042
18PCGF2_27294783_Chip-Seq_NPCs_Mouse1.86365809
19ZNF274_21170338_ChIP-Seq_K562_Hela1.86345092
20BMI1_23680149_ChIP-Seq_NPCS_Mouse1.83091498
21JARID2_20064375_ChIP-Seq_MESCs_Mouse1.77822170
22TBX3_20139965_ChIP-Seq_MESCs_Mouse1.76577782
23TBX3_20139965_ChIP-Seq_ESCs_Mouse1.76508116
24EZH2_27304074_Chip-Seq_ESCs_Mouse1.74304647
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.73909857
26P53_22127205_ChIP-Seq_FIBROBLAST_Human1.70527564
27GATA1_26923725_Chip-Seq_HPCs_Mouse1.66606771
28SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.61482596
29SUZ12_27294783_Chip-Seq_NPCs_Mouse1.61467638
30VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.59903281
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.59571736
32ETV2_25802403_ChIP-Seq_MESCs_Mouse1.54476975
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.53923211
34CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.51648148
35RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.46305920
36EZH2_18974828_ChIP-Seq_MESCs_Mouse1.46088241
37RNF2_18974828_ChIP-Seq_MESCs_Mouse1.46088241
38KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.45251361
39SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.44872562
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.43165975
41SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.43093324
42JARID2_20075857_ChIP-Seq_MESCs_Mouse1.41318407
43IGF1R_20145208_ChIP-Seq_DFB_Human1.36937192
44SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.36808008
45STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.33383038
46CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31663957
47TDRD3_21172665_ChIP-Seq_MCF-7_Human1.31062949
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.30765141
49AHR_22903824_ChIP-Seq_MCF-7_Human1.30013257
50EED_16625203_ChIP-ChIP_MESCs_Mouse1.28797572
51SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.27951246
52IRF1_19129219_ChIP-ChIP_H3396_Human1.27878093
53NFE2_27457419_Chip-Seq_LIVER_Mouse1.26941123
54PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.26897055
55MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25502294
56EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25030319
57TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24018591
58POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22456933
59TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22456933
60PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21484895
61EZH2_27294783_Chip-Seq_ESCs_Mouse1.19584356
62MYC_18940864_ChIP-ChIP_HL60_Human1.14610187
63SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.12296829
64WDR5_24793694_ChIP-Seq_LNCAP_Human1.11447674
65AUTS2_25519132_ChIP-Seq_293T-REX_Human1.09474172
66ELF1_17652178_ChIP-ChIP_JURKAT_Human1.09299900
67SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.09115817
68FOXH1_21741376_ChIP-Seq_ESCs_Human1.08682399
69CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.08123680
70KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08023207
71SOX2_16153702_ChIP-ChIP_HESCs_Human1.06718436
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06700441
73FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.06502563
74RUNX2_22187159_ChIP-Seq_PCA_Human1.05870925
75EZH2_27294783_Chip-Seq_NPCs_Mouse1.04732749
76HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.04652156
77NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.03961052
78EST1_17652178_ChIP-ChIP_JURKAT_Human1.03165109
79YY1_21170310_ChIP-Seq_MESCs_Mouse1.03036417
80LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02306964
81RNF2_27304074_Chip-Seq_ESCs_Mouse1.01204964
82TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.00770284
83NCOR_22424771_ChIP-Seq_293T_Human1.00462067
84CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00284385
85ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.98879685
86SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.96372696
87EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.95172875
88NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.94664730
89P300_19829295_ChIP-Seq_ESCs_Human0.94255248
90GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.93377930
91CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.92244773
92TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91931318
93TAF2_19829295_ChIP-Seq_ESCs_Human0.91427763
94FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.91011171
95MTF2_20144788_ChIP-Seq_MESCs_Mouse0.90874921
96NANOG_20526341_ChIP-Seq_ESCs_Human0.89664079
97STAT3_18555785_Chip-Seq_ESCs_Mouse0.89277305
98STAT3_23295773_ChIP-Seq_U87_Human0.88421174
99SMAD4_21799915_ChIP-Seq_A2780_Human0.87536118
100SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.86982820

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue6.30037789
2MP0006292_abnormal_olfactory_placode3.50894131
3MP0004145_abnormal_muscle_electrophysio3.45569241
4MP0004147_increased_porphyrin_level3.02364220
5MP0000372_irregular_coat_pigmentation2.99987356
6MP0001348_abnormal_lacrimal_gland2.91316859
7MP0005410_abnormal_fertilization2.64312254
8MP0001661_extended_life_span2.50479306
9MP0002163_abnormal_gland_morphology2.40070263
10MP0005503_abnormal_tendon_morphology2.32889887
11MP0002102_abnormal_ear_morphology2.31212439
12MP0002938_white_spotting2.30037270
13MP0004130_abnormal_muscle_cell2.28520711
14MP0003880_abnormal_central_pattern2.08713885
15MP0005083_abnormal_biliary_tract2.05918687
16MP0006035_abnormal_mitochondrial_morpho1.99786465
17MP0005379_endocrine/exocrine_gland_phen1.99510510
18MP0005645_abnormal_hypothalamus_physiol1.96942104
19MP0003195_calcinosis1.92036938
20MP0008789_abnormal_olfactory_epithelium1.91056326
21MP0000462_abnormal_digestive_system1.80038064
22MP0005377_hearing/vestibular/ear_phenot1.75487790
23MP0003878_abnormal_ear_physiology1.75487790
24MP0002277_abnormal_respiratory_mucosa1.67577189
25MP0002095_abnormal_skin_pigmentation1.67248209
26MP0003136_yellow_coat_color1.67226191
27MP0000534_abnormal_ureter_morphology1.62218815
28MP0010030_abnormal_orbit_morphology1.56666860
29MP0005174_abnormal_tail_pigmentation1.53646446
30MP0004142_abnormal_muscle_tone1.50874754
31MP0000579_abnormal_nail_morphology1.47147081
32MP0009046_muscle_twitch1.46151764
33MP0005084_abnormal_gallbladder_morpholo1.42816768
34MP0005394_taste/olfaction_phenotype1.41053740
35MP0005499_abnormal_olfactory_system1.41053740
36MP0002160_abnormal_reproductive_system1.36871276
37MP0001664_abnormal_digestion1.33728209
38MP0005187_abnormal_penis_morphology1.31091184
39MP0004885_abnormal_endolymph1.28996286
40MP0003787_abnormal_imprinting1.27008427
41MP0002837_dystrophic_cardiac_calcinosis1.26514502
42MP0005253_abnormal_eye_physiology1.25542087
43MP0005551_abnormal_eye_electrophysiolog1.25043219
44MP0003436_decreased_susceptibility_to1.24081593
45MP0002876_abnormal_thyroid_physiology1.22415881
46MP0002736_abnormal_nociception_after1.18393540
47MP0009250_abnormal_appendicular_skeleto1.17531960
48MP0006072_abnormal_retinal_apoptosis1.15827372
49MP0000751_myopathy1.14653353
50MP0000631_abnormal_neuroendocrine_gland1.13292263
51MP0001986_abnormal_taste_sensitivity1.11611743
52MP0000015_abnormal_ear_pigmentation1.10286844
53MP0009764_decreased_sensitivity_to1.09341504
54MP0003937_abnormal_limbs/digits/tail_de1.08385175
55MP0002184_abnormal_innervation1.06347477
56MP0009745_abnormal_behavioral_response1.00867505
57MP0002272_abnormal_nervous_system0.99839958
58MP0001502_abnormal_circadian_rhythm0.99376759
59MP0003137_abnormal_impulse_conducting0.98870835
60MP0008775_abnormal_heart_ventricle0.97490948
61MP0000639_abnormal_adrenal_gland0.96300793
62MP0005389_reproductive_system_phenotype0.95593418
63MP0004215_abnormal_myocardial_fiber0.93543228
64MP0002557_abnormal_social/conspecific_i0.93092803
65MP0005197_abnormal_uvea_morphology0.92726848
66MP0003718_maternal_effect0.92135720
67MP0002971_abnormal_brown_adipose0.89312694
68MP0009379_abnormal_foot_pigmentation0.86974113
69MP0001486_abnormal_startle_reflex0.86833446
70MP0008004_abnormal_stomach_pH0.86386560
71MP0002108_abnormal_muscle_morphology0.85875637
72MP0003635_abnormal_synaptic_transmissio0.85558533
73MP0001542_abnormal_bone_strength0.83460339
74MP0003122_maternal_imprinting0.82639259
75MP0003959_abnormal_lean_body0.81322263
76MP0003315_abnormal_perineum_morphology0.80782537
77MP0002752_abnormal_somatic_nervous0.77498346
78MP0002233_abnormal_nose_morphology0.76029909
79MP0004957_abnormal_blastocyst_morpholog0.75498187
80MP0001293_anophthalmia0.75473696
81MP0005171_absent_coat_pigmentation0.75255481
82MP0001501_abnormal_sleep_pattern0.72661317
83MP0005195_abnormal_posterior_eye0.71165656
84MP0002148_abnormal_hypersensitivity_rea0.70985590
85MP0005636_abnormal_mineral_homeostasis0.70867721
86MP0006276_abnormal_autonomic_nervous0.69291565
87MP0005423_abnormal_somatic_nervous0.69192215
88MP0001324_abnormal_eye_pigmentation0.68595778
89MP0002822_catalepsy0.67741752
90MP0000778_abnormal_nervous_system0.67058527
91MP0009384_cardiac_valve_regurgitation0.66176210
92MP0005646_abnormal_pituitary_gland0.64867455
93MP0008872_abnormal_physiological_respon0.64616406
94MP0002734_abnormal_mechanical_nocicepti0.63934850
95MP0005408_hypopigmentation0.63721186
96MP0001968_abnormal_touch/_nociception0.62955906
97MP0001727_abnormal_embryo_implantation0.61836702
98MP0003936_abnormal_reproductive_system0.60171745
99MP0008995_early_reproductive_senescence0.59932408
100MP0002751_abnormal_autonomic_nervous0.59727619

Predicted human phenotypes

RankGene SetZ-score
1Cerebral hypomyelination (HP:0006808)7.72152681
2Concave nail (HP:0001598)5.33019420
3Premature ovarian failure (HP:0008209)4.31277511
4Agitation (HP:0000713)4.02656586
5Delusions (HP:0000746)3.87087933
6Aplasia of the musculature (HP:0100854)3.86257697
7CNS hypomyelination (HP:0003429)3.79137270
8Prolonged neonatal jaundice (HP:0006579)3.77604241
9Bifid tongue (HP:0010297)3.60966335
10Oral leukoplakia (HP:0002745)3.57410086
11Aplastic anemia (HP:0001915)3.44750967
12Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)3.34266982
13Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)3.31408272
14Personality changes (HP:0000751)3.27546278
15Postnatal microcephaly (HP:0005484)3.26355023
16Secondary amenorrhea (HP:0000869)3.24940975
17Reticulocytosis (HP:0001923)3.09987303
18Pendular nystagmus (HP:0012043)3.09906750
19Macrocytic anemia (HP:0001972)3.05825156
20Abnormality of the phalanges of the 5th finger (HP:0004213)2.96322911
21Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.96042946
22Mesomelia (HP:0003027)2.92464499
23Hypoplasia of the uterus (HP:0000013)2.88381279
24Small epiphyses (HP:0010585)2.82417850
25Adrenal hypoplasia (HP:0000835)2.82235914
26Rib fusion (HP:0000902)2.76976540
27Pallor (HP:0000980)2.72157550
28Unsteady gait (HP:0002317)2.64664568
29Septo-optic dysplasia (HP:0100842)2.63026346
30Abnormality of reticulocytes (HP:0004312)2.62053473
31Abnormality of the phalanges of the 2nd finger (HP:0009541)2.57838923
32Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.51882781
33Increased corneal curvature (HP:0100692)2.49662380
34Keratoconus (HP:0000563)2.49662380
35Symphalangism affecting the phalanges of the hand (HP:0009773)2.48677519
36Testicular atrophy (HP:0000029)2.48590776
37Short tibia (HP:0005736)2.47768904
38Hypercortisolism (HP:0001578)2.44730553
39Absent phalangeal crease (HP:0006109)2.43922921
40Alveolar cell carcinoma (HP:0006519)2.41549956
41Short middle phalanx of the 5th finger (HP:0004220)2.41383054
42Renal tubular acidosis (HP:0001947)2.39545881
43Hyperventilation (HP:0002883)2.38722884
44Abnormality of cells of the erythroid lineage (HP:0012130)2.36444140
45Aplasia/Hypoplasia of the tibia (HP:0005772)2.36442364
46Pigmentary retinal degeneration (HP:0001146)2.34524830
47Short femoral neck (HP:0100864)2.34440235
48Abnormal number of erythroid precursors (HP:0012131)2.32204782
49Anophthalmia (HP:0000528)2.30252188
50IgM deficiency (HP:0002850)2.29068715
51Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.27267749
52Delayed epiphyseal ossification (HP:0002663)2.25486500
53Neoplasm of the tracheobronchial system (HP:0100552)2.17691110
54Sudden death (HP:0001699)2.16277020
55Irregular epiphyses (HP:0010582)2.14784195
56Optic nerve hypoplasia (HP:0000609)2.14554297
57Abnormality of the proximal phalanges of the hand (HP:0009834)2.13550840
58Abnormality of cochlea (HP:0000375)2.13272889
59Hepatoblastoma (HP:0002884)2.11292976
60Dyskinesia (HP:0100660)2.09055408
61Aplasia/Hypoplasia of the sacrum (HP:0008517)2.08287276
62Renal tubular dysfunction (HP:0000124)2.07447643
63Aplasia/hypoplasia of the uterus (HP:0008684)2.05707297
64Abnormality of the heme biosynthetic pathway (HP:0010472)2.04590950
65Morphological abnormality of the inner ear (HP:0011390)2.01315050
66Truncal obesity (HP:0001956)1.99598179
67Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.98799367
68CNS demyelination (HP:0007305)1.97986825
69Severe muscular hypotonia (HP:0006829)1.96829575
70Osteomalacia (HP:0002749)1.94183008
71Congenital stationary night blindness (HP:0007642)1.93845759
72Abnormal finger flexion creases (HP:0006143)1.93557439
73Hypomagnesemia (HP:0002917)1.91738783
74Striae distensae (HP:0001065)1.91559725
75Aplasia/Hypoplasia involving the musculature (HP:0001460)1.87404931
76Abnormal ciliary motility (HP:0012262)1.87283927
77Status epilepticus (HP:0002133)1.86599877
78Pterygium (HP:0001059)1.86278055
79Bile duct proliferation (HP:0001408)1.85528421
80Abnormal biliary tract physiology (HP:0012439)1.85528421
81Hyperglycinemia (HP:0002154)1.84729735
82Submucous cleft hard palate (HP:0000176)1.83037422
83Renal cortical cysts (HP:0000803)1.81741913
84Synostosis of carpal bones (HP:0005048)1.81419226
85Ulnar deviation of the wrist (HP:0003049)1.81354452
86Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.80538984
87Abnormality of the middle phalanges of the toes (HP:0010183)1.79983161
88Type 2 muscle fiber atrophy (HP:0003554)1.77477012
89Aplasia/hypoplasia of the femur (HP:0005613)1.76747462
90Fibular hypoplasia (HP:0003038)1.75782981
91Depressed nasal ridge (HP:0000457)1.75460766
92Increased hepatocellular lipid droplets (HP:0006565)1.74511194
93Abnormal hemoglobin (HP:0011902)1.73000729
94Abnormal number of incisors (HP:0011064)1.71852602
95Restlessness (HP:0000711)1.70707581
96Facial diplegia (HP:0001349)1.70463280
97Colon cancer (HP:0003003)1.69592202
98Renal Fanconi syndrome (HP:0001994)1.67771103
99Neoplasm of the adrenal cortex (HP:0100641)1.66839943
100Asplenia (HP:0001746)1.66785551

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRKCI4.13990843
2BMPR24.07531997
3MAP4K12.04000149
4PDPK12.01095993
5RIPK114.0984706
6PRKCG1.86234754
7DAPK31.73414295
8NEK11.61933112
9YES11.40484946
10PRKCE1.26230845
11FRK1.26147370
12MAPKAPK31.20876520
13PRKCZ1.15209345
14EIF2AK31.04483057
15PASK1.02626630
16EPHA40.94520842
17WNK30.94405911
18STK38L0.91409236
19PRKCD0.87937880
20STK240.87634310
21CASK0.83824894
22WNK40.79924878
23PIK3CA0.76916026
24TRIM280.75277741
25FGR0.69425872
26STK380.60072199
27MAP2K70.59425749
28MAP3K40.57789237
29STK390.56757529
30TIE10.55420826
31INSRR0.54560146
32MARK10.54523963
33GRK10.53765007
34FLT30.51353933
35WEE10.51168242
36BCR0.49686905
37PTK20.48813255
38PRKCB0.47801408
39ZAK0.44221928
40OXSR10.42736057
41MUSK0.42666280
42MTOR0.41822362
43MYLK0.41409859
44NUAK10.38405344
45OBSCN0.38254055
46MAP4K20.37734099
47PRKCQ0.36279323
48CDK150.34287898
49TNIK0.33856335
50NTRK30.33441370
51MAPK100.33224472
52IKBKB0.33180108
53FYN0.33081461
54CDK180.32917535
55ILK0.32046231
56DYRK20.31605950
57DAPK10.31260885
58CSK0.31058333
59TRIB30.30569815
60ADRBK20.30364810
61SRC0.29620749
62PKN10.29231627
63CDK11A0.28345601
64CSNK2A20.28242174
65CSNK2A10.27766768
66DMPK0.27541023
67MAPK130.27365669
68PTK2B0.26955911
69CSNK1A10.26041367
70CDK140.25163854
71EPHB20.24907309
72STK40.24449756
73PDK20.23240650
74NTRK10.22157641
75MAP3K120.22111646
76CAMK2A0.22097324
77MAPK150.21995857
78NTRK20.18855131
79PAK30.17689260
80PRKCA0.17013314
81ERBB40.15107113
82BMPR1B0.14958938
83MET0.14849925
84LCK0.14153519
85BRSK20.13918171
86CAMKK10.13622243
87PRKACA0.13402553
88FGFR10.13359375
89CCNB10.12875645
90AKT10.12513783
91PRKD10.12363485
92EPHB10.12254781
93ROCK10.11421680
94PLK40.11094120
95EPHA20.11080758
96CSNK1G10.11053182
97CSNK1G30.10606772
98IGF1R0.10034688
99RPS6KA50.09993985
100MINK10.09457894

Predicted pathways (KEGG)

RankGene SetZ-score
1Tyrosine metabolism_Homo sapiens_hsa003505.60019356
2Sulfur relay system_Homo sapiens_hsa041224.53441746
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001304.27447680
4Ribosome_Homo sapiens_hsa030103.15814368
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.82780317
6ErbB signaling pathway_Homo sapiens_hsa040122.67339025
7Lysine degradation_Homo sapiens_hsa003102.37389030
8Longevity regulating pathway - multiple species_Homo sapiens_hsa042132.16156327
9Fatty acid metabolism_Homo sapiens_hsa012121.98905902
10RNA degradation_Homo sapiens_hsa030181.98681584
11mTOR signaling pathway_Homo sapiens_hsa041501.94887243
12Graft-versus-host disease_Homo sapiens_hsa053321.89312051
13Olfactory transduction_Homo sapiens_hsa047401.87343380
14Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.78006478
15Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.73338050
16Cardiac muscle contraction_Homo sapiens_hsa042601.70478549
17Protein export_Homo sapiens_hsa030601.70134133
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.64487795
19Phototransduction_Homo sapiens_hsa047441.64270932
20Regulation of autophagy_Homo sapiens_hsa041401.63148598
21Acute myeloid leukemia_Homo sapiens_hsa052211.57293600
22Longevity regulating pathway - mammal_Homo sapiens_hsa042111.51721332
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.47566840
24Tight junction_Homo sapiens_hsa045301.41943891
25TGF-beta signaling pathway_Homo sapiens_hsa043501.35420602
26Choline metabolism in cancer_Homo sapiens_hsa052311.34144020
27Oxidative phosphorylation_Homo sapiens_hsa001901.25371557
28Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.18290066
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.14578528
30Insulin resistance_Homo sapiens_hsa049311.13532955
31Parkinsons disease_Homo sapiens_hsa050121.06306778
32Axon guidance_Homo sapiens_hsa043601.05764304
33Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.02761595
34Fatty acid degradation_Homo sapiens_hsa000710.97172388
35Fat digestion and absorption_Homo sapiens_hsa049750.97162303
36Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.91934376
37Nicotine addiction_Homo sapiens_hsa050330.91810753
38Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.91766288
39HIF-1 signaling pathway_Homo sapiens_hsa040660.90517458
40AMPK signaling pathway_Homo sapiens_hsa041520.87687657
41NF-kappa B signaling pathway_Homo sapiens_hsa040640.87001241
42Carbohydrate digestion and absorption_Homo sapiens_hsa049730.86713038
43Protein digestion and absorption_Homo sapiens_hsa049740.84738624
44Dorso-ventral axis formation_Homo sapiens_hsa043200.84343852
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.82719832
46Mineral absorption_Homo sapiens_hsa049780.82687388
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.82033330
48Glutathione metabolism_Homo sapiens_hsa004800.77069808
49Peroxisome_Homo sapiens_hsa041460.76198963
50Nitrogen metabolism_Homo sapiens_hsa009100.76132128
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74566115
52Steroid biosynthesis_Homo sapiens_hsa001000.74377693
53T cell receptor signaling pathway_Homo sapiens_hsa046600.70341585
54Glycerolipid metabolism_Homo sapiens_hsa005610.70298395
55Huntingtons disease_Homo sapiens_hsa050160.67120770
56Butanoate metabolism_Homo sapiens_hsa006500.65987878
57Linoleic acid metabolism_Homo sapiens_hsa005910.65877717
58RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.64785674
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.64116065
60Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.61849890
61Antigen processing and presentation_Homo sapiens_hsa046120.58901868
62Asthma_Homo sapiens_hsa053100.58706684
63Pentose phosphate pathway_Homo sapiens_hsa000300.57877585
64Tryptophan metabolism_Homo sapiens_hsa003800.57294760
65Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.56960865
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56933046
67RNA transport_Homo sapiens_hsa030130.55281082
68Gastric acid secretion_Homo sapiens_hsa049710.53717940
69Salivary secretion_Homo sapiens_hsa049700.53672725
70Morphine addiction_Homo sapiens_hsa050320.52003403
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51573736
72RNA polymerase_Homo sapiens_hsa030200.51272087
73Malaria_Homo sapiens_hsa051440.51076437
74Alzheimers disease_Homo sapiens_hsa050100.50711515
75Insulin secretion_Homo sapiens_hsa049110.50159670
76Insulin signaling pathway_Homo sapiens_hsa049100.47812704
77Pancreatic secretion_Homo sapiens_hsa049720.45479822
78Maturity onset diabetes of the young_Homo sapiens_hsa049500.44009402
79Chemical carcinogenesis_Homo sapiens_hsa052040.43585466
80Caffeine metabolism_Homo sapiens_hsa002320.43584568
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41724760
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41674189
83PI3K-Akt signaling pathway_Homo sapiens_hsa041510.40847353
84Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.34685704
85Complement and coagulation cascades_Homo sapiens_hsa046100.34587006
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34435294
87Taste transduction_Homo sapiens_hsa047420.34089363
88PPAR signaling pathway_Homo sapiens_hsa033200.33508091
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.31725429
90Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.31657441
91Autoimmune thyroid disease_Homo sapiens_hsa053200.29003142
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.28067855
93Intestinal immune network for IgA production_Homo sapiens_hsa046720.27782822
94Bile secretion_Homo sapiens_hsa049760.27510183
95Pyrimidine metabolism_Homo sapiens_hsa002400.24887930
96Thyroid hormone synthesis_Homo sapiens_hsa049180.24556090
97Proteoglycans in cancer_Homo sapiens_hsa052050.24077769
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.23980575
99beta-Alanine metabolism_Homo sapiens_hsa004100.23022219
100Dilated cardiomyopathy_Homo sapiens_hsa054140.22946334

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