SNRPGP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of antigen processing and presentation of peptide antigen (GO:0002583)9.67706088
2viral transcription (GO:0019083)6.90354638
3ribosomal large subunit biogenesis (GO:0042273)6.83204570
4translational termination (GO:0006415)6.69090455
5ribosomal small subunit assembly (GO:0000028)6.65667040
6activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO5.91699972
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.82761372
8protein targeting to ER (GO:0045047)5.75471106
9cotranslational protein targeting to membrane (GO:0006613)5.72600463
10maturation of SSU-rRNA (GO:0030490)5.68422569
11establishment of protein localization to endoplasmic reticulum (GO:0072599)5.47790262
12translational elongation (GO:0006414)5.41162866
13protein localization to endoplasmic reticulum (GO:0070972)5.38037058
14cellular protein complex disassembly (GO:0043624)5.19714914
15viral life cycle (GO:0019058)5.15130005
16positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)5.06935637
17ribosomal small subunit biogenesis (GO:0042274)5.06685685
18nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.00902669
19regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)4.61357690
20mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.56456138
21regulation of antigen processing and presentation (GO:0002577)4.55746178
22translational initiation (GO:0006413)4.44512578
23protein complex disassembly (GO:0043241)4.42075253
24macromolecular complex disassembly (GO:0032984)4.18068968
25regulation of hypersensitivity (GO:0002883)4.14810466
26ATP synthesis coupled proton transport (GO:0015986)4.14054026
27energy coupled proton transport, down electrochemical gradient (GO:0015985)4.14054026
28protein targeting to membrane (GO:0006612)3.96695144
29otic vesicle formation (GO:0030916)3.92850505
30negative regulation of defense response to virus (GO:0050687)3.90912778
31positive regulation of viral genome replication (GO:0045070)3.81832745
32translation (GO:0006412)3.72973595
33nonmotile primary cilium assembly (GO:0035058)3.65602959
34axoneme assembly (GO:0035082)3.65376008
35lens fiber cell development (GO:0070307)3.64824980
36negative regulation of T cell differentiation in thymus (GO:0033085)3.61294633
37nuclear-transcribed mRNA catabolic process (GO:0000956)3.52596934
38CENP-A containing nucleosome assembly (GO:0034080)3.48339578
39spliceosomal complex assembly (GO:0000245)3.47472921
40T-helper 1 type immune response (GO:0042088)3.42625647
41protein localization to chromosome, centromeric region (GO:0071459)3.38092519
42mRNA catabolic process (GO:0006402)3.35826388
43chromatin remodeling at centromere (GO:0031055)3.35575991
44mast cell activation involved in immune response (GO:0002279)3.35332509
45mast cell degranulation (GO:0043303)3.35332509
46oxidative phosphorylation (GO:0006119)3.30735526
47protein localization to kinetochore (GO:0034501)3.27629852
48immunoglobulin mediated immune response (GO:0016064)3.24420721
49ribonucleoprotein complex biogenesis (GO:0022613)3.21485128
50cellular response to dexamethasone stimulus (GO:0071549)3.19856468
51glomerular filtration (GO:0003094)3.17980769
52RNA catabolic process (GO:0006401)3.17890687
53limb bud formation (GO:0060174)3.09640932
54V(D)J recombination (GO:0033151)3.05830007
55embryonic body morphogenesis (GO:0010172)3.04881249
56positive regulation of muscle cell apoptotic process (GO:0010661)3.02805314
57cell wall macromolecule catabolic process (GO:0016998)3.01400820
58positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.00857462
59response to dexamethasone (GO:0071548)2.99828671
60regulation of viral entry into host cell (GO:0046596)2.96172090
61attachment of spindle microtubules to kinetochore (GO:0008608)2.93094346
62termination of RNA polymerase III transcription (GO:0006386)2.90048102
63transcription elongation from RNA polymerase III promoter (GO:0006385)2.90048102
64establishment of protein localization to mitochondrial membrane (GO:0090151)2.89298641
65cellular extravasation (GO:0045123)2.89139987
66innate immune response in mucosa (GO:0002227)2.88621678
67regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)2.85455667
68renal filtration (GO:0097205)2.83823233
69negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.83733956
70T cell migration (GO:0072678)2.82071499
71male sex determination (GO:0030238)2.80926779
72negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.79752969
73negative regulation of response to biotic stimulus (GO:0002832)2.79604405
74negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.78526652
75mast cell activation (GO:0045576)2.72992781
76cell wall macromolecule metabolic process (GO:0044036)2.72348296
77cellular component biogenesis (GO:0044085)2.70457607
78platelet formation (GO:0030220)2.70138272
79B cell mediated immunity (GO:0019724)2.69883743
80anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.66943857
81histone exchange (GO:0043486)2.66045474
82oligosaccharide catabolic process (GO:0009313)2.64294613
83regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.64282337
84DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.62738902
85behavioral response to nicotine (GO:0035095)2.61919936
86DNA ligation (GO:0006266)2.61166553
87negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.60975500
88B cell homeostasis (GO:0001782)2.59739339
89regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.59271148
90regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.59134583
91antibacterial humoral response (GO:0019731)2.58367503
92intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.58361953
93signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.58361953
94positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.57262587
95ATP biosynthetic process (GO:0006754)2.56439549
96protein targeting (GO:0006605)2.56334422
97positive regulation of mast cell activation (GO:0033005)2.55676488
98establishment of protein localization to membrane (GO:0090150)2.55220363
99pattern specification involved in kidney development (GO:0061004)2.54635824
100signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.53777042

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.10686016
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.94608420
3E2F7_22180533_ChIP-Seq_HELA_Human3.84541276
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.78941851
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.74489553
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.67575553
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.43988802
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.40252967
9IRF8_22096565_ChIP-ChIP_GC-B_Human3.04743694
10GATA1_22025678_ChIP-Seq_K562_Human2.84033242
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.74646704
12VDR_23849224_ChIP-Seq_CD4+_Human2.68782636
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.58175468
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.51822492
15POU5F1_16153702_ChIP-ChIP_HESCs_Human2.49202231
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.47303732
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.43862603
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.33726623
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.33699664
20ELK1_19687146_ChIP-ChIP_HELA_Human2.32465765
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.26530579
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.26311015
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.25775020
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.21998909
25MYC_18358816_ChIP-ChIP_MESCs_Mouse2.20367238
26EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.17078958
27SOX2_16153702_ChIP-ChIP_HESCs_Human2.16258031
28SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.10015974
29JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.06780303
30BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.05174857
31MYC_19030024_ChIP-ChIP_MESCs_Mouse2.04933855
32TTF2_22483619_ChIP-Seq_HELA_Human2.01914274
33IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.99022933
34FOXP3_21729870_ChIP-Seq_TREG_Human1.95195380
35XRN2_22483619_ChIP-Seq_HELA_Human1.93908299
36E2F1_21310950_ChIP-Seq_MCF-7_Human1.87870063
37POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.87440879
38MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.79162772
39FLI1_27457419_Chip-Seq_LIVER_Mouse1.77260506
40KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.77243576
41VDR_22108803_ChIP-Seq_LS180_Human1.76488229
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.75947162
43E2F1_18555785_ChIP-Seq_MESCs_Mouse1.75344655
44EWS_26573619_Chip-Seq_HEK293_Human1.74918269
45IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.73825474
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.68222218
47MYC_18940864_ChIP-ChIP_HL60_Human1.63386822
48NELFA_20434984_ChIP-Seq_ESCs_Mouse1.62958937
49CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.60380234
50HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.58576059
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.58542995
52CIITA_25753668_ChIP-Seq_RAJI_Human1.58392480
53SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.57276177
54POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.55565428
55MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.52543427
56DCP1A_22483619_ChIP-Seq_HELA_Human1.49804930
57AR_21909140_ChIP-Seq_LNCAP_Human1.36407754
58SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.33548866
59NANOG_16153702_ChIP-ChIP_HESCs_Human1.30284066
60BMI1_23680149_ChIP-Seq_NPCS_Mouse1.29986202
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.29908769
62THAP11_20581084_ChIP-Seq_MESCs_Mouse1.29588651
63CBX2_27304074_Chip-Seq_ESCs_Mouse1.29326903
64PADI4_21655091_ChIP-ChIP_MCF-7_Human1.29089387
65CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.27330700
66STAT4_19710469_ChIP-ChIP_TH1__Mouse1.25319740
67AUTS2_25519132_ChIP-Seq_293T-REX_Human1.23846836
68YY1_21170310_ChIP-Seq_MESCs_Mouse1.21321361
69SRF_21415370_ChIP-Seq_HL-1_Mouse1.21156304
70PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20353577
71SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.12607410
72EGR1_23403033_ChIP-Seq_LIVER_Mouse1.12146610
73TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.10131919
74PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.08970240
75GABP_19822575_ChIP-Seq_HepG2_Human1.06345325
76RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04959471
77NANOG_18555785_ChIP-Seq_MESCs_Mouse1.03655793
78SOX2_18555785_ChIP-Seq_MESCs_Mouse1.01124380
79ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.00964363
80ERG_20887958_ChIP-Seq_HPC-7_Mouse1.00588915
81FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.98098354
82RNF2_27304074_Chip-Seq_NSC_Mouse0.97628454
83CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97256728
84NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.94982651
85TP63_19390658_ChIP-ChIP_HaCaT_Human0.94836743
86MYC_22102868_ChIP-Seq_BL_Human0.94817290
87TDRD3_21172665_ChIP-Seq_MCF-7_Human0.93301280
88FUS_26573619_Chip-Seq_HEK293_Human0.90686722
89YY1_22570637_ChIP-Seq_MALME-3M_Human0.88638623
90MYC_19829295_ChIP-Seq_ESCs_Human0.86359801
91BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.86116415
92SPI1_20517297_ChIP-Seq_HL60_Human0.84299399
93PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.81903492
94EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.77418931
95TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.76412173
96CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.76079655
97ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.73998262
98CDX2_20551321_ChIP-Seq_CACO-2_Human0.73644788
99FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.72405180
100GATA3_26560356_Chip-Seq_TH2_Human0.72369735

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis5.34698162
2MP0008789_abnormal_olfactory_epithelium3.83395871
3MP0001835_abnormal_antigen_presentation3.45989089
4MP0005394_taste/olfaction_phenotype3.16863387
5MP0005499_abnormal_olfactory_system3.16863387
6MP0003763_abnormal_thymus_physiology3.00285131
7MP0009379_abnormal_foot_pigmentation2.97076980
8MP0003136_yellow_coat_color2.96196693
9MP0000685_abnormal_immune_system2.70609013
10MP0005671_abnormal_response_to2.62671504
11MP0002006_tumorigenesis2.60874014
12MP0003693_abnormal_embryo_hatching2.39533007
13MP0004957_abnormal_blastocyst_morpholog2.25092243
14MP0005645_abnormal_hypothalamus_physiol2.23399080
15MP0000569_abnormal_digit_pigmentation2.23224120
16MP0002282_abnormal_trachea_morphology2.15164905
17MP0002166_altered_tumor_susceptibility2.09095916
18MP0005387_immune_system_phenotype2.08810061
19MP0001790_abnormal_immune_system2.08810061
20MP0004142_abnormal_muscle_tone2.04280385
21MP0010094_abnormal_chromosome_stability2.01088954
22MP0009333_abnormal_splenocyte_physiolog2.00693606
23MP0001529_abnormal_vocalization1.93145476
24MP0006292_abnormal_olfactory_placode1.90231582
25MP0001293_anophthalmia1.86269486
26MP0005084_abnormal_gallbladder_morpholo1.84227526
27MP0001800_abnormal_humoral_immune1.83345119
28MP0003315_abnormal_perineum_morphology1.73673679
29MP0002277_abnormal_respiratory_mucosa1.68146904
30MP0003436_decreased_susceptibility_to1.66342993
31MP0002938_white_spotting1.65013325
32MP0001346_abnormal_lacrimal_gland1.54340112
33MP0002148_abnormal_hypersensitivity_rea1.50358204
34MP0010386_abnormal_urinary_bladder1.50107986
35MP0003077_abnormal_cell_cycle1.48203432
36MP0003186_abnormal_redox_activity1.42417197
37MP0000490_abnormal_crypts_of1.40643905
38MP0006072_abnormal_retinal_apoptosis1.36482627
39MP0005000_abnormal_immune_tolerance1.34210641
40MP0002452_abnormal_antigen_presenting1.34118270
41MP0000631_abnormal_neuroendocrine_gland1.31276255
42MP0009053_abnormal_anal_canal1.30876881
43MP0001986_abnormal_taste_sensitivity1.30019948
44MP0000537_abnormal_urethra_morphology1.29530320
45MP0000013_abnormal_adipose_tissue1.26836728
46MP0003786_premature_aging1.24678926
47MP0010030_abnormal_orbit_morphology1.24452013
48MP0002723_abnormal_immune_serum1.21927169
49MP0003806_abnormal_nucleotide_metabolis1.21847078
50MP0009785_altered_susceptibility_to1.21801576
51MP0003567_abnormal_fetal_cardiomyocyte1.20448612
52MP0006036_abnormal_mitochondrial_physio1.16758943
53MP0002102_abnormal_ear_morphology1.16329517
54MP0001819_abnormal_immune_cell1.13108994
55MP0003111_abnormal_nucleus_morphology1.13075424
56MP0002420_abnormal_adaptive_immunity1.11622620
57MP0000428_abnormal_craniofacial_morphol1.09964701
58MP0003283_abnormal_digestive_organ1.08392640
59MP0002233_abnormal_nose_morphology1.04196533
60MP0002098_abnormal_vibrissa_morphology1.02682311
61MP0002095_abnormal_skin_pigmentation1.01000778
62MP0003937_abnormal_limbs/digits/tail_de0.96178112
63MP0008872_abnormal_physiological_respon0.95199964
64MP0008058_abnormal_DNA_repair0.94374234
65MP0002398_abnormal_bone_marrow0.93934446
66MP0000049_abnormal_middle_ear0.91978072
67MP0004145_abnormal_muscle_electrophysio0.87835243
68MP0000716_abnormal_immune_system0.85754485
69MP0001853_heart_inflammation0.84046530
70MP0002009_preneoplasia0.79476696
71MP0002837_dystrophic_cardiac_calcinosis0.78727765
72MP0002822_catalepsy0.74816659
73MP0000778_abnormal_nervous_system0.74579442
74MP0008932_abnormal_embryonic_tissue0.73348779
75MP0001873_stomach_inflammation0.71762736
76MP0000383_abnormal_hair_follicle0.71608927
77MP0002429_abnormal_blood_cell0.71167292
78MP0001905_abnormal_dopamine_level0.68858769
79MP0000538_abnormal_urinary_bladder0.68614550
80MP0001727_abnormal_embryo_implantation0.67386893
81MP0000689_abnormal_spleen_morphology0.66155423
82MP0008961_abnormal_basal_metabolism0.65163384
83MP0010155_abnormal_intestine_physiology0.63586277
84MP0001485_abnormal_pinna_reflex0.63438891
85MP0009250_abnormal_appendicular_skeleto0.63277582
86MP0000372_irregular_coat_pigmentation0.61800162
87MP0003011_delayed_dark_adaptation0.61759904
88MP0005025_abnormal_response_to0.61469023
89MP0000026_abnormal_inner_ear0.60790670
90MP0002090_abnormal_vision0.60565977
91MP0005423_abnormal_somatic_nervous0.58815934
92MP0008007_abnormal_cellular_replicative0.58120039
93MP0001533_abnormal_skeleton_physiology0.57468378
94MP0002751_abnormal_autonomic_nervous0.56094773
95MP0001286_abnormal_eye_development0.51790256
96MP0005171_absent_coat_pigmentation0.51325516
97MP0000350_abnormal_cell_proliferation0.51059502
98MP0002419_abnormal_innate_immunity0.50665046
99MP0002210_abnormal_sex_determination0.50426507
100MP0002722_abnormal_immune_system0.50420246

Predicted human phenotypes

RankGene SetZ-score
1Chronic sinusitis (HP:0011109)4.54740944
2Abnormal ciliary motility (HP:0012262)4.47942900
3Aplasia/Hypoplasia of the sacrum (HP:0008517)4.44500485
4Abnormal respiratory epithelium morphology (HP:0012253)4.17177653
5Abnormal respiratory motile cilium morphology (HP:0005938)4.17177653
6Increased intramyocellular lipid droplets (HP:0012240)4.16001398
7Abnormal number of erythroid precursors (HP:0012131)3.82993593
8Maternal diabetes (HP:0009800)3.72633831
9Abnormality of cells of the erythroid lineage (HP:0012130)3.71816388
10Increased hepatocellular lipid droplets (HP:0006565)3.46890975
11Coronal craniosynostosis (HP:0004440)3.45817319
12Congenital, generalized hypertrichosis (HP:0004540)3.45496944
13Multiple enchondromatosis (HP:0005701)3.45279673
14Increased muscle lipid content (HP:0009058)3.43166424
15Abnormal respiratory motile cilium physiology (HP:0012261)3.36441375
16Decreased activity of mitochondrial respiratory chain (HP:0008972)3.34153545
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.34153545
18Conical tooth (HP:0000698)3.32864893
19Abnormal pupillary function (HP:0007686)3.24200005
20Macrocytic anemia (HP:0001972)3.22606189
21Partial duplication of thumb phalanx (HP:0009944)3.21219743
22Split foot (HP:0001839)3.19641640
23Reticulocytopenia (HP:0001896)3.15589415
24Stenosis of the external auditory canal (HP:0000402)3.11678599
25IgM deficiency (HP:0002850)3.09160543
26Abnormality of the middle phalanges of the toes (HP:0010183)3.09133458
27Down-sloping shoulders (HP:0200021)3.07279009
28Lipid accumulation in hepatocytes (HP:0006561)2.83174862
29Aplasia involving bones of the upper limbs (HP:0009823)2.82429413
30Aplasia of the phalanges of the hand (HP:0009802)2.82429413
31Aplasia involving bones of the extremities (HP:0009825)2.82429413
32Rhinitis (HP:0012384)2.81292803
33Pallor (HP:0000980)2.80480402
34Partial duplication of the phalanx of hand (HP:0009999)2.76964479
35Abnormality of the phalanges of the 2nd finger (HP:0009541)2.70410695
36Abnormality of the musculature of the hand (HP:0001421)2.68030507
37Renal Fanconi syndrome (HP:0001994)2.66571083
38Cleft eyelid (HP:0000625)2.62099784
39Abnormal delayed hypersensitivity skin test (HP:0002963)2.60798650
40Acute necrotizing encephalopathy (HP:0006965)2.57421994
41Mitochondrial inheritance (HP:0001427)2.51927642
42Spastic diplegia (HP:0001264)2.50436427
43Areflexia of lower limbs (HP:0002522)2.49243754
44Choanal stenosis (HP:0000452)2.47002937
45IgG deficiency (HP:0004315)2.46254504
46Abnormality of alanine metabolism (HP:0010916)2.44372956
47Hyperalaninemia (HP:0003348)2.44372956
48Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.44372956
49Neonatal short-limb short stature (HP:0008921)2.43334824
50Abnormal mitochondria in muscle tissue (HP:0008316)2.42582329
51Anophthalmia (HP:0000528)2.42419401
52Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.41984436
53Septo-optic dysplasia (HP:0100842)2.39926524
54Exercise intolerance (HP:0003546)2.37694503
55Myelomeningocele (HP:0002475)2.37132622
56Agammaglobulinemia (HP:0004432)2.36497143
57Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.36117636
58Exertional dyspnea (HP:0002875)2.35755719
59Abnormality of the lacrimal duct (HP:0011481)2.34099724
60Nasolacrimal duct obstruction (HP:0000579)2.33807080
61Gastrointestinal stroma tumor (HP:0100723)2.33771011
62Abnormality of the 2nd finger (HP:0004100)2.33638574
633-Methylglutaconic aciduria (HP:0003535)2.31504882
64Increased CSF lactate (HP:0002490)2.30126694
65Abnormality of the labia minora (HP:0012880)2.27738371
66Abnormality of T cell physiology (HP:0011840)2.26981802
67Acute encephalopathy (HP:0006846)2.25611023
68Absent septum pellucidum (HP:0001331)2.24515307
69Stomatitis (HP:0010280)2.24240228
70Bronchiectasis (HP:0002110)2.19988204
71Broad hallux (HP:0010055)2.18900646
72Xerostomia (HP:0000217)2.18455949
73Abnormality of incisor morphology (HP:0011063)2.15107259
74Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.14245647
75Concave nail (HP:0001598)2.12248687
76Triphalangeal thumb (HP:0001199)2.11882511
77Abnormality of the incisor (HP:0000676)2.11258933
78Abnormal number of incisors (HP:0011064)2.10716125
79Glossoptosis (HP:0000162)2.07886394
80Panhypogammaglobulinemia (HP:0003139)2.07174624
81Selective tooth agenesis (HP:0001592)2.07168149
82Abnormality of the parietal bone (HP:0002696)2.04575990
83Chronic otitis media (HP:0000389)2.02900530
84Progressive macrocephaly (HP:0004481)2.01458181
85Increased serum lactate (HP:0002151)1.96723531
86Overfolded helix (HP:0000396)1.96181374
87Humeroradial synostosis (HP:0003041)1.95714387
88Synostosis involving the elbow (HP:0003938)1.95714387
89Duplication of thumb phalanx (HP:0009942)1.95016489
90Microretrognathia (HP:0000308)1.94018719
91Respiratory difficulties (HP:0002880)1.92981459
92Recurrent sinusitis (HP:0011108)1.92848366
93Premature skin wrinkling (HP:0100678)1.91358676
94Hepatocellular necrosis (HP:0001404)1.89771753
95Rectal prolapse (HP:0002035)1.89404197
96Chronic obstructive pulmonary disease (HP:0006510)1.88548160
97Obstructive lung disease (HP:0006536)1.88548160
98Broad toe (HP:0001837)1.87905428
99Abnormality of the nasolacrimal system (HP:0000614)1.85777307
100Hypoplasia of the ulna (HP:0003022)1.85771121

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.58295835
2NEK94.61055568
3VRK23.70188529
4MAP2K23.56150211
5VRK13.35342642
6EIF2AK12.98529366
7TLK12.75276283
8PNCK2.55465918
9WEE12.18915569
10TNK22.18711143
11FGFR22.12595812
12STK38L1.96347031
13ZAK1.77559754
14CDC71.72965242
15TAOK31.72167453
16PASK1.58634496
17MAP2K11.49215869
18MAP3K41.48629596
19MKNK21.48499233
20SRPK11.46034984
21MKNK11.39393125
22KDR1.37009020
23TESK21.35334378
24DAPK31.35093183
25NEK11.34340401
26MST41.33612580
27TSSK61.29519949
28PINK11.27673766
29RPS6KA51.26667137
30TXK1.22432856
31AURKB1.12545443
32CSF1R1.11908076
33NUAK11.06540055
34PDK21.04444123
35STK161.02029254
36RPS6KB21.01682866
37MAP3K141.01242512
38MARK30.99975441
39FGFR10.95746378
40DYRK1A0.94557467
41EPHB20.93595470
42EIF2AK30.91249591
43MAP3K100.89432019
44EIF2AK20.88951848
45PLK40.87282979
46PTK60.86093190
47AURKA0.85296402
48DYRK20.84968692
49PLK30.84270853
50NME20.82339905
51ADRBK20.82179719
52ERBB20.80090864
53ILK0.74220555
54PIM10.72416884
55LYN0.72416455
56UHMK10.71208299
57CDK80.70087440
58PIM20.69646059
59MUSK0.69540769
60SMG10.68796166
61NME10.67677427
62MYLK0.64388977
63IKBKB0.61382586
64BTK0.61146570
65CSNK2A10.61128426
66ALK0.60502109
67IRAK40.58283777
68KIT0.57850964
69PRKCQ0.57798837
70LIMK10.56426041
71MAP4K10.56164622
72CCNB10.55059245
73CDK70.54752169
74CSNK2A20.53846936
75CSNK1G20.47130550
76TAF10.45483176
77PLK10.45276043
78ABL10.44786881
79TTK0.44187746
80MAP3K130.43925426
81MAP4K20.43664827
82MAPK150.43459348
83CSNK1G30.41125902
84CHUK0.40563461
85CHEK20.39023323
86RPS6KA60.38081129
87INSRR0.38000190
88STK100.34227941
89ERBB40.34192994
90LRRK20.33243167
91SYK0.32718568
92ARAF0.31422448
93JAK10.30644299
94PRKCD0.27491010
95IKBKE0.26523617
96CDK190.24482381
97MOS0.24174069
98ATR0.23858803
99LATS10.23359773
100TESK10.22635022

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053105.33978332
2Ribosome_Homo sapiens_hsa030104.65245589
3Intestinal immune network for IgA production_Homo sapiens_hsa046724.20723616
4Allograft rejection_Homo sapiens_hsa053304.16067705
5Autoimmune thyroid disease_Homo sapiens_hsa053203.94832491
6Graft-versus-host disease_Homo sapiens_hsa053323.92672840
7Systemic lupus erythematosus_Homo sapiens_hsa053223.71435757
8Type I diabetes mellitus_Homo sapiens_hsa049403.36503309
9Viral myocarditis_Homo sapiens_hsa054163.12276200
10Antigen processing and presentation_Homo sapiens_hsa046122.74736021
11Proteasome_Homo sapiens_hsa030502.56219609
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.30343841
13Primary immunodeficiency_Homo sapiens_hsa053402.07662896
14Oxidative phosphorylation_Homo sapiens_hsa001901.97627520
15Rheumatoid arthritis_Homo sapiens_hsa053231.96930036
16Parkinsons disease_Homo sapiens_hsa050121.94127838
17Staphylococcus aureus infection_Homo sapiens_hsa051501.77003528
18Leishmaniasis_Homo sapiens_hsa051401.72046955
19DNA replication_Homo sapiens_hsa030301.57861510
20Alcoholism_Homo sapiens_hsa050341.52452068
21RNA polymerase_Homo sapiens_hsa030201.42979815
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.31131719
23Huntingtons disease_Homo sapiens_hsa050161.27298967
24Toxoplasmosis_Homo sapiens_hsa051451.27083115
25Protein export_Homo sapiens_hsa030601.25563980
26Spliceosome_Homo sapiens_hsa030401.22653168
27Mismatch repair_Homo sapiens_hsa034301.16711071
28Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.09059050
29Alzheimers disease_Homo sapiens_hsa050101.08197177
30Influenza A_Homo sapiens_hsa051640.99758935
31Epstein-Barr virus infection_Homo sapiens_hsa051690.94722989
32Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.91340837
33Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.89648236
34Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.89095022
35Herpes simplex infection_Homo sapiens_hsa051680.81122942
36Tuberculosis_Homo sapiens_hsa051520.79212770
37Hematopoietic cell lineage_Homo sapiens_hsa046400.77423896
38Nucleotide excision repair_Homo sapiens_hsa034200.74754951
39Legionellosis_Homo sapiens_hsa051340.70255107
40Phagosome_Homo sapiens_hsa041450.69630309
41Phototransduction_Homo sapiens_hsa047440.69525846
42RNA degradation_Homo sapiens_hsa030180.69341561
43RNA transport_Homo sapiens_hsa030130.66252470
44p53 signaling pathway_Homo sapiens_hsa041150.64916394
45Cardiac muscle contraction_Homo sapiens_hsa042600.63486968
46Pyrimidine metabolism_Homo sapiens_hsa002400.63058049
47Homologous recombination_Homo sapiens_hsa034400.62555526
48Basal transcription factors_Homo sapiens_hsa030220.61439718
49Base excision repair_Homo sapiens_hsa034100.61343164
50One carbon pool by folate_Homo sapiens_hsa006700.60589492
51Selenocompound metabolism_Homo sapiens_hsa004500.55937227
52Fanconi anemia pathway_Homo sapiens_hsa034600.52166143
53Maturity onset diabetes of the young_Homo sapiens_hsa049500.51749055
54NF-kappa B signaling pathway_Homo sapiens_hsa040640.51030174
55Cell cycle_Homo sapiens_hsa041100.48888224
56Propanoate metabolism_Homo sapiens_hsa006400.48849041
57Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48462642
58Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44867592
59Viral carcinogenesis_Homo sapiens_hsa052030.44322916
60Glutathione metabolism_Homo sapiens_hsa004800.43508146
61HTLV-I infection_Homo sapiens_hsa051660.39868322
62Folate biosynthesis_Homo sapiens_hsa007900.38786918
63Purine metabolism_Homo sapiens_hsa002300.37808797
64Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34507057
65Basal cell carcinoma_Homo sapiens_hsa052170.34472834
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.29254429
67Nitrogen metabolism_Homo sapiens_hsa009100.28554956
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.26855039
69NOD-like receptor signaling pathway_Homo sapiens_hsa046210.26794010
70B cell receptor signaling pathway_Homo sapiens_hsa046620.25985570
71Colorectal cancer_Homo sapiens_hsa052100.23184042
72Regulation of autophagy_Homo sapiens_hsa041400.21656273
73Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.21586118
74Carbon metabolism_Homo sapiens_hsa012000.19284073
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.17730260
76Non-homologous end-joining_Homo sapiens_hsa034500.16503043
77Small cell lung cancer_Homo sapiens_hsa052220.15690050
78Shigellosis_Homo sapiens_hsa051310.15407376
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.13806681
80Tryptophan metabolism_Homo sapiens_hsa003800.13774587
81Measles_Homo sapiens_hsa051620.13646760
822-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.13310814
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.13286223
84Collecting duct acid secretion_Homo sapiens_hsa049660.11939797
85Salmonella infection_Homo sapiens_hsa051320.11719098
86Toll-like receptor signaling pathway_Homo sapiens_hsa046200.11478598
87Caffeine metabolism_Homo sapiens_hsa002320.09912866
88Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.09791663
89Prostate cancer_Homo sapiens_hsa052150.09428212
90Biosynthesis of amino acids_Homo sapiens_hsa012300.09335580
91Apoptosis_Homo sapiens_hsa042100.08572487
92Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.08120745
93Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.07434910
94Olfactory transduction_Homo sapiens_hsa047400.05584493
95Phenylalanine metabolism_Homo sapiens_hsa003600.05028398
96Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.04353950
97Melanoma_Homo sapiens_hsa052180.04251024
98African trypanosomiasis_Homo sapiens_hsa051430.02926322
99Malaria_Homo sapiens_hsa051440.02453670
100Arachidonic acid metabolism_Homo sapiens_hsa005900.02166668

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