SNRPGP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021108.97931731
2mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)8.97931731
3intra-S DNA damage checkpoint (GO:0031573)8.29432972
4regulation of transforming growth factor beta2 production (GO:0032909)7.41218896
5UDP-N-acetylglucosamine metabolic process (GO:0006047)6.54231014
6regulation of RIG-I signaling pathway (GO:0039535)6.47107170
7positive regulation of mitochondrial membrane permeability (GO:0035794)6.36900496
8regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)5.82392431
9activated T cell proliferation (GO:0050798)5.78671278
10spliceosomal tri-snRNP complex assembly (GO:0000244)5.77198321
11positive regulation of mRNA catabolic process (GO:0061014)5.75576837
12macrophage differentiation (GO:0030225)5.34505626
13nucleotide-sugar biosynthetic process (GO:0009226)4.86575646
14regulation of mRNA catabolic process (GO:0061013)4.79353068
15regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)4.74734582
16negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.63977974
17positive regulation of transforming growth factor beta production (GO:0071636)4.43169347
18positive regulation of interferon-beta production (GO:0032728)4.27162981
19ribosome assembly (GO:0042255)4.25037437
20DNA methylation involved in gamete generation (GO:0043046)4.22356781
21piRNA metabolic process (GO:0034587)4.18476343
22negative regulation of viral genome replication (GO:0045071)4.16545876
23necroptotic process (GO:0070266)4.13534197
24regulation of interferon-alpha production (GO:0032647)4.00899763
25programmed necrotic cell death (GO:0097300)3.98154316
26protein localization to cell surface (GO:0034394)3.98149338
27male meiosis I (GO:0007141)3.93275567
28positive regulation of interferon-alpha production (GO:0032727)3.89750412
29regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.85641541
30platelet dense granule organization (GO:0060155)3.85013454
31regulation of hexokinase activity (GO:1903299)3.80305595
32regulation of glucokinase activity (GO:0033131)3.80305595
33photoreceptor cell maintenance (GO:0045494)3.75239545
34necrotic cell death (GO:0070265)3.73194673
35keratinocyte development (GO:0003334)3.70833338
36limb bud formation (GO:0060174)3.70492936
37detection of light stimulus involved in visual perception (GO:0050908)3.66682495
38detection of light stimulus involved in sensory perception (GO:0050962)3.66682495
39positive regulation of mRNA metabolic process (GO:1903313)3.64569513
40nucleotide-sugar metabolic process (GO:0009225)3.55085532
41regulation of interferon-beta production (GO:0032648)3.51719984
42purinergic nucleotide receptor signaling pathway (GO:0035590)3.45761713
43response to interferon-beta (GO:0035456)3.39438251
44male meiosis (GO:0007140)3.38022173
45cellular response to arsenic-containing substance (GO:0071243)3.37670867
46meiosis I (GO:0007127)3.32940260
47negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.32283931
48pharyngeal system development (GO:0060037)3.29403767
49reciprocal meiotic recombination (GO:0007131)3.27064118
50reciprocal DNA recombination (GO:0035825)3.27064118
51T cell apoptotic process (GO:0070231)3.22364690
52L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.17322020
53G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.16657863
54protein-chromophore linkage (GO:0018298)3.16263424
55tyrosine phosphorylation of STAT protein (GO:0007260)3.16027186
56regulation of transmission of nerve impulse (GO:0051969)3.10275582
57positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.10100632
58negative regulation of mast cell activation (GO:0033004)3.07224073
59positive regulation of toll-like receptor signaling pathway (GO:0034123)3.06313596
60regulation of viral genome replication (GO:0045069)3.05150492
61lymphocyte apoptotic process (GO:0070227)3.02422349
62dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.00598947
63prenylation (GO:0097354)2.98567523
64protein prenylation (GO:0018342)2.98567523
65methionine biosynthetic process (GO:0009086)2.95941956
66regulation of B cell receptor signaling pathway (GO:0050855)2.94674633
67negative regulation of neurological system process (GO:0031645)2.92893615
68response to pheromone (GO:0019236)2.91313573
69eye photoreceptor cell development (GO:0042462)2.90674007
70positive regulation of translational initiation (GO:0045948)2.88279418
71amino acid salvage (GO:0043102)2.84893260
72L-methionine salvage (GO:0071267)2.84893260
73L-methionine biosynthetic process (GO:0071265)2.84893260
74photoreceptor cell development (GO:0042461)2.84840482
75transcription elongation from RNA polymerase I promoter (GO:0006362)2.84495418
76DNA deamination (GO:0045006)2.81063590
77cellular biogenic amine catabolic process (GO:0042402)2.80603876
78amine catabolic process (GO:0009310)2.80603876
79positive regulation of natural killer cell mediated immunity (GO:0002717)2.80187019
80negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.77334954
81diterpenoid biosynthetic process (GO:0016102)2.76619601
82negative regulation of nitric-oxide synthase activity (GO:0051001)2.75741422
83glutamine metabolic process (GO:0006541)2.74989130
84response to interleukin-15 (GO:0070672)2.73794888
85positive regulation of organelle assembly (GO:1902117)2.73740653
86DNA excision (GO:0044349)2.72697477
87nucleotide-excision repair, DNA damage removal (GO:0000718)2.72697477
88neuromuscular process controlling posture (GO:0050884)2.72055099
89synapsis (GO:0007129)2.71855167
90fibroblast migration (GO:0010761)2.70566243
91negative regulation of T cell receptor signaling pathway (GO:0050860)2.69877124
92sulfur amino acid catabolic process (GO:0000098)2.69038851
93positive regulation of T cell cytokine production (GO:0002726)2.68835062
94behavioral response to nicotine (GO:0035095)2.68119512
95nonmotile primary cilium assembly (GO:0035058)2.67384606
96peroxisome fission (GO:0016559)2.66761575
97regulation of alkaline phosphatase activity (GO:0010692)2.62811128
98mannose metabolic process (GO:0006013)2.62248376
99positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.61271877
100positive regulation of protein homooligomerization (GO:0032464)2.59515942

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.83762531
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.71325026
3SMAD_19615063_ChIP-ChIP_OVARY_Human4.39877234
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.23554178
5GATA1_22025678_ChIP-Seq_K562_Human3.53172886
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.94139398
7VDR_22108803_ChIP-Seq_LS180_Human2.90777384
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.69665857
9GBX2_23144817_ChIP-Seq_PC3_Human2.63169351
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.29126472
11NOTCH1_21737748_ChIP-Seq_TLL_Human2.25823652
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.18063150
13IGF1R_20145208_ChIP-Seq_DFB_Human2.17768852
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.16996202
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.04157236
16PCGF2_27294783_Chip-Seq_ESCs_Mouse2.01368118
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.92150163
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.90705719
19POU3F2_20337985_ChIP-ChIP_501MEL_Human1.90646965
20PCGF2_27294783_Chip-Seq_NPCs_Mouse1.87786861
21IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.87647241
22ZNF274_21170338_ChIP-Seq_K562_Hela1.85085913
23EZH2_27294783_Chip-Seq_NPCs_Mouse1.83063791
24NFE2_27457419_Chip-Seq_LIVER_Mouse1.80698984
25SUZ12_27294783_Chip-Seq_NPCs_Mouse1.76814535
26IRF8_21731497_ChIP-ChIP_J774_Mouse1.71479903
27CRX_20693478_ChIP-Seq_RETINA_Mouse1.59559271
28ER_23166858_ChIP-Seq_MCF-7_Human1.57187294
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.50567853
30EGR1_23403033_ChIP-Seq_LIVER_Mouse1.49538070
31CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.43006432
32BCAT_22108803_ChIP-Seq_LS180_Human1.39885409
33IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.38760173
34STAT3_23295773_ChIP-Seq_U87_Human1.37548692
35GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.37298216
36E2F1_18555785_Chip-Seq_ESCs_Mouse1.36419677
37PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.35575578
38OCT4_18555785_Chip-Seq_ESCs_Mouse1.34562405
39SUZ12_18555785_Chip-Seq_ESCs_Mouse1.33973458
40NANOG_18555785_Chip-Seq_ESCs_Mouse1.33386022
41FUS_26573619_Chip-Seq_HEK293_Human1.33211115
42SMAD1_18555785_Chip-Seq_ESCs_Mouse1.32791755
43P53_22387025_ChIP-Seq_ESCs_Mouse1.31463840
44OCT4_21477851_ChIP-Seq_ESCs_Mouse1.30677315
45SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.30263238
46EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.30235561
47TCF4_22108803_ChIP-Seq_LS180_Human1.29287423
48CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.27926569
49CDX2_22108803_ChIP-Seq_LS180_Human1.26156993
50TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25930377
51SMAD4_21799915_ChIP-Seq_A2780_Human1.25374470
52P300_18555785_Chip-Seq_ESCs_Mouse1.25235956
53STAT3_18555785_Chip-Seq_ESCs_Mouse1.24793445
54NANOG_19829295_ChIP-Seq_ESCs_Human1.24145608
55SOX2_19829295_ChIP-Seq_ESCs_Human1.24145608
56SMRT_27268052_Chip-Seq_Bcells_Human1.23337824
57EWS_26573619_Chip-Seq_HEK293_Human1.22749699
58ZFP57_27257070_Chip-Seq_ESCs_Mouse1.21380098
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.18693605
60FLI1_21867929_ChIP-Seq_TH2_Mouse1.18072688
61TCF4_23295773_ChIP-Seq_U87_Human1.17416117
62GATA3_26560356_Chip-Seq_TH2_Human1.16843730
63RUNX1_27457419_Chip-Seq_LIVER_Mouse1.16084073
64GABP_17652178_ChIP-ChIP_JURKAT_Human1.15935031
65EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.15442006
66CTCF_18555785_Chip-Seq_ESCs_Mouse1.15401548
67SMAD3_21741376_ChIP-Seq_EPCs_Human1.14906733
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14488567
69P300_19829295_ChIP-Seq_ESCs_Human1.14183091
70HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.12376597
71CMYC_18555785_Chip-Seq_ESCs_Mouse1.12330151
72FOXA1_25329375_ChIP-Seq_VCAP_Human1.11856313
73FOXA1_27270436_Chip-Seq_PROSTATE_Human1.11856313
74SOX2_18555785_Chip-Seq_ESCs_Mouse1.11638029
75NMYC_18555785_Chip-Seq_ESCs_Mouse1.11418755
76KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10836689
77SMAD4_21741376_ChIP-Seq_EPCs_Human1.10695078
78PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.10387872
79SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.09797796
80TP53_22573176_ChIP-Seq_HFKS_Human1.09677246
81ZFX_18555785_Chip-Seq_ESCs_Mouse1.09242059
82GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08376108
83AR_20517297_ChIP-Seq_VCAP_Human1.07465840
84NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07229325
85FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06464979
86PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.06286406
87KLF4_18555785_Chip-Seq_ESCs_Mouse1.03507743
88RBPJ_22232070_ChIP-Seq_NCS_Mouse1.02767024
89PU1_27457419_Chip-Seq_LIVER_Mouse1.02035180
90FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01188401
91PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00446204
92VDR_23849224_ChIP-Seq_CD4+_Human1.00021995
93CBP_20019798_ChIP-Seq_JUKART_Human0.99441612
94IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99441612
95HOXB7_26014856_ChIP-Seq_BT474_Human0.98109101
96EGR1_19032775_ChIP-ChIP_M12_Human0.97413557
97UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97312503
98LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.95180656
99STAT4_19710469_ChIP-ChIP_TH1__Mouse0.95043519
100EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.94854388

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002638_abnormal_pupillary_reflex4.14787007
2MP0005670_abnormal_white_adipose3.95900321
3MP0003763_abnormal_thymus_physiology3.01746375
4MP0008877_abnormal_DNA_methylation2.94333857
5MP0002876_abnormal_thyroid_physiology2.69909981
6MP0002254_reproductive_system_inflammat2.63863016
7MP0010386_abnormal_urinary_bladder2.48480048
8MP0005671_abnormal_response_to2.33353574
9MP0000427_abnormal_hair_cycle2.33137554
10MP0009785_altered_susceptibility_to2.30185741
11MP0004885_abnormal_endolymph2.11700500
12MP0005551_abnormal_eye_electrophysiolog1.99311349
13MP0002653_abnormal_ependyma_morphology1.98525313
14MP0000569_abnormal_digit_pigmentation1.97772328
15MP0005646_abnormal_pituitary_gland1.92376392
16MP0005365_abnormal_bile_salt1.89607565
17MP0002163_abnormal_gland_morphology1.87982862
18MP0005645_abnormal_hypothalamus_physiol1.85276400
19MP0001873_stomach_inflammation1.82827393
20MP0001835_abnormal_antigen_presentation1.82162694
21MP0003950_abnormal_plasma_membrane1.72474178
22MP0009115_abnormal_fat_cell1.71455146
23MP0002822_catalepsy1.68970025
24MP0001502_abnormal_circadian_rhythm1.66030098
25MP0005075_abnormal_melanosome_morpholog1.63129731
26MP0004134_abnormal_chest_morphology1.58948952
27MP0003787_abnormal_imprinting1.58065193
28MP0001764_abnormal_homeostasis1.53783064
29MP0003943_abnormal_hepatobiliary_system1.52924632
30MP0002166_altered_tumor_susceptibility1.49610782
31MP0004264_abnormal_extraembryonic_tissu1.48819209
32MP0000647_abnormal_sebaceous_gland1.42557390
33MP0003693_abnormal_embryo_hatching1.42295274
34MP0002723_abnormal_immune_serum1.39220203
35MP0001984_abnormal_olfaction1.36728715
36MP0005379_endocrine/exocrine_gland_phen1.36554072
37MP0001666_abnormal_nutrient_absorption1.33956103
38MP0005666_abnormal_adipose_tissue1.33629865
39MP0005408_hypopigmentation1.31223474
40MP0001800_abnormal_humoral_immune1.29104328
41MP0001851_eye_inflammation1.29079769
42MP0005076_abnormal_cell_differentiation1.27900198
43MP0002693_abnormal_pancreas_physiology1.26751757
44MP0005310_abnormal_salivary_gland1.24483560
45MP0004142_abnormal_muscle_tone1.23385118
46MP0005025_abnormal_response_to1.21752868
47MP0002006_tumorigenesis1.18386732
48MP0006276_abnormal_autonomic_nervous1.17487915
49MP0002148_abnormal_hypersensitivity_rea1.16246373
50MP0003866_abnormal_defecation1.16165130
51MP0000372_irregular_coat_pigmentation1.15742110
52MP0005174_abnormal_tail_pigmentation1.15524671
53MP0009333_abnormal_splenocyte_physiolog1.14515963
54MP0001845_abnormal_inflammatory_respons1.09215115
55MP0005187_abnormal_penis_morphology1.09167452
56MP0002837_dystrophic_cardiac_calcinosis1.07960753
57MP0009745_abnormal_behavioral_response1.07042044
58MP0006082_CNS_inflammation1.05338253
59MP0009840_abnormal_foam_cell1.05256878
60MP0005389_reproductive_system_phenotype1.02383585
61MP0005253_abnormal_eye_physiology0.98215755
62MP0010155_abnormal_intestine_physiology0.96401302
63MP0005000_abnormal_immune_tolerance0.95900191
64MP0001501_abnormal_sleep_pattern0.95510466
65MP0008875_abnormal_xenobiotic_pharmacok0.95353507
66MP0002210_abnormal_sex_determination0.95137043
67MP0008789_abnormal_olfactory_epithelium0.95014620
68MP0009046_muscle_twitch0.94155079
69MP0001919_abnormal_reproductive_system0.93229975
70MP0003567_abnormal_fetal_cardiomyocyte0.92520367
71MP0002420_abnormal_adaptive_immunity0.92087859
72MP0003283_abnormal_digestive_organ0.91301340
73MP0002102_abnormal_ear_morphology0.90318656
74MP0005386_behavior/neurological_phenoty0.89395398
75MP0004924_abnormal_behavior0.89395398
76MP0005451_abnormal_body_composition0.88962761
77MP0001819_abnormal_immune_cell0.88846352
78MP0003880_abnormal_central_pattern0.87365335
79MP0002909_abnormal_adrenal_gland0.86704994
80MP0003698_abnormal_male_reproductive0.86700263
81MP0003123_paternal_imprinting0.86032917
82MP0001348_abnormal_lacrimal_gland0.85789447
83MP0008872_abnormal_physiological_respon0.84548052
84MP0002064_seizures0.83216498
85MP0003011_delayed_dark_adaptation0.82805907
86MP0001963_abnormal_hearing_physiology0.81520373
87MP0002398_abnormal_bone_marrow0.80473284
88MP0000858_altered_metastatic_potential0.79509056
89MP0002452_abnormal_antigen_presenting0.79457613
90MP0003315_abnormal_perineum_morphology0.79351914
91MP0002229_neurodegeneration0.79003578
92MP0002078_abnormal_glucose_homeostasis0.78989211
93MP0009764_decreased_sensitivity_to0.78570751
94MP0009765_abnormal_xenobiotic_induced0.78219488
95MP0004019_abnormal_vitamin_homeostasis0.76768636
96MP0005499_abnormal_olfactory_system0.76366103
97MP0005394_taste/olfaction_phenotype0.76366103
98MP0001929_abnormal_gametogenesis0.73772970
99MP0001145_abnormal_male_reproductive0.73741043
100MP0000516_abnormal_urinary_system0.72954684

Predicted human phenotypes

RankGene SetZ-score
1Autoimmune hemolytic anemia (HP:0001890)5.10931147
2Enlarged epiphyses (HP:0010580)3.99880253
3Optic neuritis (HP:0100653)3.76280711
4Retrobulbar optic neuritis (HP:0100654)3.76280711
5Abnormality of the labia minora (HP:0012880)3.46296979
6Joint swelling (HP:0001386)3.40189209
7Progressive cerebellar ataxia (HP:0002073)3.37524812
8Increased IgM level (HP:0003496)3.09454022
9Hyperinsulinemic hypoglycemia (HP:0000825)3.06265368
10Medial flaring of the eyebrow (HP:0010747)3.05320706
11Orchitis (HP:0100796)3.00039028
12Hepatoblastoma (HP:0002884)2.96323949
13Macroorchidism (HP:0000053)2.95803742
14Fair hair (HP:0002286)2.95456248
15Progressive inability to walk (HP:0002505)2.91178888
16Exotropia (HP:0000577)2.90827827
17Hypoproteinemia (HP:0003075)2.88652740
18Congenital primary aphakia (HP:0007707)2.83124535
19Congenital stationary night blindness (HP:0007642)2.78826450
20Gait imbalance (HP:0002141)2.78326868
21Keratoconjunctivitis (HP:0001096)2.72770342
22Hyperventilation (HP:0002883)2.63713844
23Metaphyseal dysplasia (HP:0100255)2.62692241
24Stomatitis (HP:0010280)2.59291455
25Abnormality of the metopic suture (HP:0005556)2.52821680
26Ketoacidosis (HP:0001993)2.51457846
27Hemoptysis (HP:0002105)2.48411626
28Short phalanx of the thumb (HP:0009660)2.47373811
29Polyneuropathy (HP:0001271)2.43539937
30Poor coordination (HP:0002370)2.39629522
31Inability to walk (HP:0002540)2.35721718
32Absent speech (HP:0001344)2.35693348
33Nephrogenic diabetes insipidus (HP:0009806)2.34717290
34Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.32900294
35Short 1st metacarpal (HP:0010034)2.32900294
36Hypokalemic alkalosis (HP:0001949)2.32761922
37IgG deficiency (HP:0004315)2.31944680
38Hip dysplasia (HP:0001385)2.31793924
39Abnormality of macular pigmentation (HP:0008002)2.30791424
40Brushfield spots (HP:0001088)2.29861569
41Insulin-resistant diabetes mellitus (HP:0000831)2.29785208
42Bulbous nose (HP:0000414)2.27397163
43Keratoconjunctivitis sicca (HP:0001097)2.26386190
44Gaze-evoked nystagmus (HP:0000640)2.26383201
45Pulmonary infiltrates (HP:0002113)2.25735944
46Myositis (HP:0100614)2.22528283
47Aplasia/Hypoplasia of the sternum (HP:0006714)2.16936446
48Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.16744072
49Degeneration of the lateral corticospinal tracts (HP:0002314)2.16744072
50Follicular hyperkeratosis (HP:0007502)2.16248209
51Ureteral stenosis (HP:0000071)2.16151301
52Vasculitis (HP:0002633)2.13227752
53Anterior segment dysgenesis (HP:0007700)2.10694407
54Late onset (HP:0003584)2.09812943
55Widely spaced teeth (HP:0000687)2.04376954
56Abnormality of the 1st metacarpal (HP:0010009)2.04238844
57Chronic mucocutaneous candidiasis (HP:0002728)2.02342771
58Recurrent cutaneous fungal infections (HP:0011370)2.02342771
59Ureteral obstruction (HP:0006000)2.01679074
60Genital tract atresia (HP:0001827)1.98261451
61Broad-based gait (HP:0002136)1.97155318
62Macular degeneration (HP:0000608)1.96458568
63Anorexia (HP:0002039)1.96455578
64Opisthotonus (HP:0002179)1.94810054
65Type II lissencephaly (HP:0007260)1.92542151
66Severe visual impairment (HP:0001141)1.90741127
67Chronic diarrhea (HP:0002028)1.90374965
68Cerebral hypomyelination (HP:0006808)1.89405144
69Keratitis (HP:0000491)1.88318721
70Thyroiditis (HP:0100646)1.87304463
71Generalized hypopigmentation of hair (HP:0011358)1.86157738
72Pancreatic fibrosis (HP:0100732)1.85524896
73Vaginal atresia (HP:0000148)1.83653123
74Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.82562029
75Macroglossia (HP:0000158)1.82363132
76Gangrene (HP:0100758)1.80614739
77Arterial thrombosis (HP:0004420)1.79499989
78Abnormality of the corticospinal tract (HP:0002492)1.79387420
79Abnormality of the fingertips (HP:0001211)1.79102609
80True hermaphroditism (HP:0010459)1.76957500
81Increased corneal curvature (HP:0100692)1.76621700
82Keratoconus (HP:0000563)1.76621700
83Abnormal hair whorl (HP:0010721)1.76493809
84Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.76321931
85Abnormality of the renal medulla (HP:0100957)1.75622758
86Ketosis (HP:0001946)1.75510414
87Abnormality of the renal cortex (HP:0011035)1.75479857
88Papilledema (HP:0001085)1.73955623
89Metabolic alkalosis (HP:0200114)1.72073568
90Horizontal nystagmus (HP:0000666)1.72030215
91Urinary bladder sphincter dysfunction (HP:0002839)1.67580929
92Alacrima (HP:0000522)1.67383521
93Hypsarrhythmia (HP:0002521)1.66210283
94Hypochromic anemia (HP:0001931)1.66018635
95Hypomagnesemia (HP:0002917)1.65975660
96Chin dimple (HP:0010751)1.65736499
97Long clavicles (HP:0000890)1.64879557
98Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.63215776
99Volvulus (HP:0002580)1.63100634
100Specific learning disability (HP:0001328)1.61734909

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK17.56020193
2VRK14.75741045
3PINK13.20670820
4TRIM283.05247429
5BCR2.74639226
6CDK82.67724558
7TYRO32.65102310
8TXK2.58349211
9MAP4K22.40848753
10FRK2.40577016
11TAOK32.16188544
12FES2.09969911
13IRAK32.09092408
14SIK32.02714018
15PIK3CA1.96718424
16MAP2K61.93650796
17MST41.93305824
18TRPM71.91924002
19TNIK1.81202418
20ADRBK21.68841060
21TGFBR21.66091159
22PLK31.65547271
23KSR11.62963298
24JAK31.45443233
25BMPR1B1.43522733
26PRPF4B1.43156155
27CAMK1D1.42610110
28GRK11.27418147
29STK38L1.26883950
30TYK21.16750544
31ZAK1.15530603
32MARK31.07630417
33EIF2AK11.04997905
34PDGFRB1.03689267
35PRKCE1.01702017
36CAMK1G1.00841738
37NUAK10.93797000
38PTK2B0.90038752
39JAK10.88860812
40OXSR10.85716039
41ITK0.80848742
42PDK20.79170723
43STK240.77614915
44ACVR1B0.75812977
45EPHA20.73828168
46IGF1R0.68672841
47PIM10.65729310
48CSK0.65045230
49BTK0.63779937
50KIT0.63708174
51IKBKE0.61334862
52PHKG20.60714193
53PHKG10.60714193
54PAK30.59892183
55MAPK130.59585934
56PRKCI0.58453320
57IRAK10.57200431
58NLK0.54417291
59AKT30.54108945
60STK110.54060565
61MAPKAPK30.52008924
62LCK0.51819162
63TEC0.49594285
64CSNK1D0.49529282
65MARK10.49117262
66FGFR30.46630302
67BUB10.45751302
68MELK0.43302949
69HCK0.42785807
70CASK0.42561969
71PRKCZ0.42152528
72ABL20.40996567
73INSRR0.40449136
74DYRK1A0.38505886
75PRKACA0.38091545
76FGFR40.37137446
77CDK30.35642955
78LYN0.35186535
79MAP3K120.35160159
80MAPK110.34114147
81ERBB30.33921237
82MAP3K90.33248947
83STK390.33173586
84PTK60.31110971
85WNK30.30801957
86PDK10.29861560
87PRKAA10.29859548
88CAMK10.29749353
89PRKG10.29532624
90PRKCQ0.28726978
91PRKCG0.27088788
92IKBKB0.26879914
93PRKACG0.26670723
94HIPK20.26309627
95CHUK0.24901990
96TBK10.23608734
97PRKCA0.21746171
98NEK60.21322734
99MINK10.20308764
100PTK20.19677391

Predicted pathways (KEGG)

RankGene SetZ-score
1Selenocompound metabolism_Homo sapiens_hsa004503.40136071
2Basal transcription factors_Homo sapiens_hsa030223.35046649
3Nucleotide excision repair_Homo sapiens_hsa034202.98653930
4Homologous recombination_Homo sapiens_hsa034402.93313170
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.82173478
6One carbon pool by folate_Homo sapiens_hsa006702.77212680
7Mismatch repair_Homo sapiens_hsa034302.68559585
8Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002502.49426467
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.47178057
10Measles_Homo sapiens_hsa051622.33688624
11Proteasome_Homo sapiens_hsa030502.21645136
12Dorso-ventral axis formation_Homo sapiens_hsa043202.17173284
13Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.92990339
14Linoleic acid metabolism_Homo sapiens_hsa005911.88665023
15Cocaine addiction_Homo sapiens_hsa050301.76562893
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.75732887
17Butanoate metabolism_Homo sapiens_hsa006501.74513009
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.72934667
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.71819449
20Protein export_Homo sapiens_hsa030601.57195899
21Fanconi anemia pathway_Homo sapiens_hsa034601.56200681
22Peroxisome_Homo sapiens_hsa041461.54232768
23Graft-versus-host disease_Homo sapiens_hsa053321.51403087
24Primary immunodeficiency_Homo sapiens_hsa053401.48361478
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44146114
26T cell receptor signaling pathway_Homo sapiens_hsa046601.43633739
27Nitrogen metabolism_Homo sapiens_hsa009101.43414013
28Hepatitis B_Homo sapiens_hsa051611.42632144
29Phototransduction_Homo sapiens_hsa047441.36421347
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.36070169
31Insulin secretion_Homo sapiens_hsa049111.30287203
32Caffeine metabolism_Homo sapiens_hsa002321.29474751
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.23982384
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.18630923
35Tryptophan metabolism_Homo sapiens_hsa003801.17142951
36Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.17081986
37Ether lipid metabolism_Homo sapiens_hsa005651.06614761
38Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.03484204
39TNF signaling pathway_Homo sapiens_hsa046681.02323742
40Amphetamine addiction_Homo sapiens_hsa050311.02109818
41Intestinal immune network for IgA production_Homo sapiens_hsa046721.01375698
42Jak-STAT signaling pathway_Homo sapiens_hsa046300.95947322
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.93823984
44Thyroid hormone synthesis_Homo sapiens_hsa049180.89686178
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.88852469
46Fatty acid metabolism_Homo sapiens_hsa012120.87069621
47Oxidative phosphorylation_Homo sapiens_hsa001900.86639030
48Dopaminergic synapse_Homo sapiens_hsa047280.86476575
49African trypanosomiasis_Homo sapiens_hsa051430.86254417
50Type I diabetes mellitus_Homo sapiens_hsa049400.85358349
51Autoimmune thyroid disease_Homo sapiens_hsa053200.84869584
52Allograft rejection_Homo sapiens_hsa053300.82273302
53ABC transporters_Homo sapiens_hsa020100.82215927
54Fat digestion and absorption_Homo sapiens_hsa049750.81848823
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.76200310
56Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.74290287
57Non-homologous end-joining_Homo sapiens_hsa034500.72557575
58Fatty acid biosynthesis_Homo sapiens_hsa000610.71521848
59Influenza A_Homo sapiens_hsa051640.69502433
60Glucagon signaling pathway_Homo sapiens_hsa049220.65058256
61Hematopoietic cell lineage_Homo sapiens_hsa046400.64925882
62Propanoate metabolism_Homo sapiens_hsa006400.64022236
63Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.63192198
64Circadian rhythm_Homo sapiens_hsa047100.61318434
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60573365
66Sphingolipid signaling pathway_Homo sapiens_hsa040710.60132402
67Nicotine addiction_Homo sapiens_hsa050330.57802477
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56322096
69N-Glycan biosynthesis_Homo sapiens_hsa005100.55525446
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55485513
71Hepatitis C_Homo sapiens_hsa051600.54573532
72Collecting duct acid secretion_Homo sapiens_hsa049660.53386780
73RNA degradation_Homo sapiens_hsa030180.51827784
74Aldosterone synthesis and secretion_Homo sapiens_hsa049250.51022369
75Mineral absorption_Homo sapiens_hsa049780.50142390
76Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.49713059
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49210965
78Parkinsons disease_Homo sapiens_hsa050120.45798632
79Glycerolipid metabolism_Homo sapiens_hsa005610.42161166
80Vitamin digestion and absorption_Homo sapiens_hsa049770.41991044
81Complement and coagulation cascades_Homo sapiens_hsa046100.41622287
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41549931
83Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.38571521
84Fructose and mannose metabolism_Homo sapiens_hsa000510.37657927
85Viral carcinogenesis_Homo sapiens_hsa052030.37169151
86Cholinergic synapse_Homo sapiens_hsa047250.35542456
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.33569075
88Toll-like receptor signaling pathway_Homo sapiens_hsa046200.33322674
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30947345
90Viral myocarditis_Homo sapiens_hsa054160.29732139
91Chemical carcinogenesis_Homo sapiens_hsa052040.29508090
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.28002690
93Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.27894345
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27870828
95Antigen processing and presentation_Homo sapiens_hsa046120.25442997
96Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.22729107
97Ovarian steroidogenesis_Homo sapiens_hsa049130.22255717
98Oocyte meiosis_Homo sapiens_hsa041140.22166136
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.21954039
100Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.20938737

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