SNRPGP8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ncRNA 3-end processing (GO:0043628)8.86799734
2skeletal muscle tissue regeneration (GO:0043403)7.12793274
3ribosomal small subunit biogenesis (GO:0042274)7.10775709
4negative regulation of muscle hypertrophy (GO:0014741)7.09438770
5muscle filament sliding (GO:0030049)6.78067926
6actin-myosin filament sliding (GO:0033275)6.78067926
7response to muscle activity (GO:0014850)6.45137876
8negative regulation of skeletal muscle tissue development (GO:0048642)6.37642612
9regulation of skeletal muscle contraction (GO:0014819)6.37589483
10protein K6-linked ubiquitination (GO:0085020)5.88479794
11actin-mediated cell contraction (GO:0070252)5.47019037
12neuronal action potential propagation (GO:0019227)5.32373352
13negative regulation of transcription by competitive promoter binding (GO:0010944)4.96355985
14gamma-aminobutyric acid transport (GO:0015812)4.95377408
15cellular response to dexamethasone stimulus (GO:0071549)4.67239613
16positive regulation of mitochondrial fission (GO:0090141)4.59126426
17response to activity (GO:0014823)4.53644439
18negative regulation of fatty acid biosynthetic process (GO:0045717)4.40293068
19coenzyme catabolic process (GO:0009109)4.35061086
20response to dexamethasone (GO:0071548)4.30464399
21striated muscle adaptation (GO:0014888)4.28281061
22viral transcription (GO:0019083)4.17151159
23regulation of protein polyubiquitination (GO:1902914)4.05273056
24translational elongation (GO:0006414)3.98577854
25myotube cell development (GO:0014904)3.97301816
26translational termination (GO:0006415)3.94815032
27protein-cofactor linkage (GO:0018065)3.93034851
28calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.87441818
29regulation of gene silencing by RNA (GO:0060966)3.87218748
30regulation of posttranscriptional gene silencing (GO:0060147)3.87218748
31regulation of gene silencing by miRNA (GO:0060964)3.87218748
32ubiquinone biosynthetic process (GO:0006744)3.81960468
33negative regulation of fatty acid metabolic process (GO:0045922)3.75216616
34skeletal muscle fiber development (GO:0048741)3.74983163
35actin filament-based movement (GO:0030048)3.70952308
36muscle adaptation (GO:0043500)3.70155733
37regulation of muscle hypertrophy (GO:0014743)3.69665397
38skeletal muscle contraction (GO:0003009)3.58832966
39cellular protein complex localization (GO:0034629)3.47500552
40regulation of activin receptor signaling pathway (GO:0032925)3.46943930
41embryonic foregut morphogenesis (GO:0048617)3.45007908
42cellular sodium ion homeostasis (GO:0006883)3.43493069
43regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.43318637
44SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.39469869
45prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.39073507
46protein targeting to ER (GO:0045047)3.33322546
47axoneme assembly (GO:0035082)3.33099401
48cotranslational protein targeting to membrane (GO:0006613)3.30568136
49rRNA methylation (GO:0031167)3.29420862
50regulation of histone H3-K9 methylation (GO:0051570)3.27111496
51regulation of relaxation of muscle (GO:1901077)3.26390711
52ubiquinone metabolic process (GO:0006743)3.23739889
53quinone biosynthetic process (GO:1901663)3.23029292
54protein localization to endoplasmic reticulum (GO:0070972)3.22061613
55base-excision repair, AP site formation (GO:0006285)3.19342262
56negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.19295024
57pyrimidine dimer repair (GO:0006290)3.18450791
58viral life cycle (GO:0019058)3.17410260
59establishment of protein localization to endoplasmic reticulum (GO:0072599)3.14605435
60regulation of alkaline phosphatase activity (GO:0010692)3.12417738
61G-protein coupled receptor internalization (GO:0002031)3.08758078
62negative regulation of peptidyl-lysine acetylation (GO:2000757)3.05750256
63regulation of centrosome duplication (GO:0010824)3.03786879
64positive regulation of fatty acid oxidation (GO:0046321)3.02327352
65regulation of mitochondrial fission (GO:0090140)3.02008624
66negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902176)3.00043371
67negative regulation of organelle assembly (GO:1902116)2.99684850
68response to electrical stimulus (GO:0051602)2.95909242
69negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.95422889
70regulation of DNA methylation (GO:0044030)2.94285108
71DNA synthesis involved in DNA repair (GO:0000731)2.93946895
72cellular protein complex disassembly (GO:0043624)2.90606901
73dicarboxylic acid catabolic process (GO:0043649)2.89870686
74regulation of transcription involved in cell fate commitment (GO:0060850)2.89052136
75rRNA modification (GO:0000154)2.85194132
76nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.84114066
77ganglion development (GO:0061548)2.83671012
78muscle organ development (GO:0007517)2.81629466
79negative regulation of protein acetylation (GO:1901984)2.76411489
80negative regulation of gene silencing (GO:0060969)2.75753245
81mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.74953825
82muscle structure development (GO:0061061)2.73144615
83regulation of stem cell maintenance (GO:2000036)2.72062821
84negative regulation of reactive oxygen species metabolic process (GO:2000378)2.68526624
85dopamine transport (GO:0015872)2.61789579
86branch elongation of an epithelium (GO:0060602)2.59344600
87anterograde synaptic vesicle transport (GO:0048490)2.55912264
88translational initiation (GO:0006413)2.55613629
89ovulation from ovarian follicle (GO:0001542)2.55187698
90mitochondrion distribution (GO:0048311)2.52425580
91anterior/posterior axis specification, embryo (GO:0008595)2.50861089
92pathway-restricted SMAD protein phosphorylation (GO:0060389)2.50550269
93positive regulation of cholesterol efflux (GO:0010875)2.48414070
94cofactor catabolic process (GO:0051187)2.47238949
95dosage compensation (GO:0007549)2.46320282
96regulation of hexokinase activity (GO:1903299)2.45374544
97skeletal muscle adaptation (GO:0043501)10.7165318
98striated muscle atrophy (GO:0014891)10.5676181
99muscle atrophy (GO:0014889)10.2085273
100response to gravity (GO:0009629)10.1685313

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat6.17458792
2VDR_22108803_ChIP-Seq_LS180_Human4.24303152
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.44855853
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.44855853
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.44855853
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.36480147
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.22781028
8CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.85594211
9EZH2_22144423_ChIP-Seq_EOC_Human2.61047476
10TAF15_26573619_Chip-Seq_HEK293_Human2.23008956
11HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.02898179
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.01242230
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse12.5743740
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse12.3089534
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.93640902
16PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.37433683
17JARID2_20075857_ChIP-Seq_MESCs_Mouse1.35287701
18TP63_19390658_ChIP-ChIP_HaCaT_Human1.28096465
19FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.25193247
20EZH2_27304074_Chip-Seq_ESCs_Mouse1.22398399
21BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20696106
22RXR_22108803_ChIP-Seq_LS180_Human1.14053888
23PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12934498
24VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.11173808
25POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10940601
26EED_16625203_ChIP-ChIP_MESCs_Mouse1.09879993
27CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99772446
28STAT6_21828071_ChIP-Seq_BEAS2B_Human0.96233848
29FUS_26573619_Chip-Seq_HEK293_Human0.90241038
30SRY_22984422_ChIP-ChIP_TESTIS_Rat0.88179473
31P300_19829295_ChIP-Seq_ESCs_Human0.85005823
32FLI1_27457419_Chip-Seq_LIVER_Mouse0.83844441
33POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.83711101
34JARID2_20064375_ChIP-Seq_MESCs_Mouse0.83427141
35ZFP57_27257070_Chip-Seq_ESCs_Mouse0.83187090
36EZH2_18974828_ChIP-Seq_MESCs_Mouse0.83165094
37RNF2_18974828_ChIP-Seq_MESCs_Mouse0.83165094
38KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.80502032
39CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.80001869
40AR_21572438_ChIP-Seq_LNCaP_Human0.79977143
41TP53_22573176_ChIP-Seq_HFKS_Human0.79287926
42SUZ12_27294783_Chip-Seq_ESCs_Mouse0.77361018
43RING1B_27294783_Chip-Seq_ESCs_Mouse0.72700444
44EZH2_27294783_Chip-Seq_ESCs_Mouse0.72480395
45CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.71631097
46CBX2_27304074_Chip-Seq_ESCs_Mouse0.71431596
47ERG_21242973_ChIP-ChIP_JURKAT_Human0.69503408
48ESR2_21235772_ChIP-Seq_MCF-7_Human0.68578949
49CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.68173278
50SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.67882280
51SOX9_26525672_Chip-Seq_HEART_Mouse0.67088031
52STAT3_23295773_ChIP-Seq_U87_Human0.66844302
53SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.65757675
54TP53_20018659_ChIP-ChIP_R1E_Mouse0.65308297
55GABP_17652178_ChIP-ChIP_JURKAT_Human0.65208997
56CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.64814398
57GATA1_22025678_ChIP-Seq_K562_Human0.64626582
58YY1_21170310_ChIP-Seq_MESCs_Mouse0.63474127
59SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.62622238
60STAT1_20625510_ChIP-Seq_HELA_Human0.61460698
61HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.60751074
62CEBPB_22108803_ChIP-Seq_LS180_Human0.60742677
63CTBP1_25329375_ChIP-Seq_LNCAP_Human0.60512704
64SA1_27219007_Chip-Seq_Bcells_Human0.59841525
65LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.57607238
66MTF2_20144788_ChIP-Seq_MESCs_Mouse0.57542414
67STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.55848509
68KDM2B_26808549_Chip-Seq_REH_Human0.55311960
69SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.54134858
70SMAD_19615063_ChIP-ChIP_OVARY_Human0.53550925
71RING1B_27294783_Chip-Seq_NPCs_Mouse0.53091770
72SOX2_18555785_ChIP-Seq_MESCs_Mouse0.50148522
73SOX2_19829295_ChIP-Seq_ESCs_Human0.50058343
74NANOG_19829295_ChIP-Seq_ESCs_Human0.50058343
75TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.49428907
76SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.49286038
77PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.48355596
78GBX2_23144817_ChIP-Seq_PC3_Human0.47755539
79LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.47467366
80EGR1_19032775_ChIP-ChIP_M12_Human0.46648991
81NFIB_24661679_ChIP-Seq_LUNG_Mouse0.46636429
82CREB1_15753290_ChIP-ChIP_HEK293T_Human0.46447360
83SMAD4_21799915_ChIP-Seq_A2780_Human0.46253125
84EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.46129522
85PCGF2_27294783_Chip-Seq_ESCs_Mouse0.45289549
86SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.45103598
87RNF2_27304074_Chip-Seq_ESCs_Mouse0.43698930
88STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.43624291
89EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.42721130
90TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.41655663
91KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.40432936
92SA1_22415368_ChIP-Seq_MEFs_Mouse0.39748190
93RNF2_27304074_Chip-Seq_NSC_Mouse0.39182340
94UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.38829902
95PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.38427158
96EST1_17652178_ChIP-ChIP_JURKAT_Human0.38079797
97EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.37697856
98CTBP2_25329375_ChIP-Seq_LNCAP_Human0.37451623
99BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.37162143
100TCF3_18692474_ChIP-Seq_MEFs_Mouse0.37100126

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004145_abnormal_muscle_electrophysio6.06336728
2MP0000747_muscle_weakness4.28512066
3MP0002138_abnormal_hepatobiliary_system4.19482672
4MP0000015_abnormal_ear_pigmentation4.05870042
5MP0004036_abnormal_muscle_relaxation3.21231958
6MP0008057_abnormal_DNA_replication2.99741673
7MP0004133_heterotaxia2.73881490
8MP0002277_abnormal_respiratory_mucosa2.61275767
9MP0005645_abnormal_hypothalamus_physiol2.60599725
10MP0002095_abnormal_skin_pigmentation2.59458725
11MP0002269_muscular_atrophy2.49674737
12MP0002108_abnormal_muscle_morphology2.38566270
13MP0002928_abnormal_bile_duct2.37086325
14MP0000759_abnormal_skeletal_muscle2.34283596
15MP0000751_myopathy2.34150936
16MP0000749_muscle_degeneration2.30000684
17MP0008789_abnormal_olfactory_epithelium2.28726485
18MP0000569_abnormal_digit_pigmentation2.19034843
19MP0000566_synostosis2.18112182
20MP0003705_abnormal_hypodermis_morpholog2.10380359
21MP0005084_abnormal_gallbladder_morpholo2.04580528
22MP0005275_abnormal_skin_tensile1.99984264
23MP0003879_abnormal_hair_cell1.96078683
24MP0003938_abnormal_ear_development1.95593282
25MP0005377_hearing/vestibular/ear_phenot1.92182315
26MP0003878_abnormal_ear_physiology1.92182315
27MP0002089_abnormal_postnatal_growth/wei1.82630673
28MP0002106_abnormal_muscle_physiology1.82427185
29MP0002139_abnormal_hepatobiliary_system1.82406781
30MP0005620_abnormal_muscle_contractility1.70322033
31MP0005670_abnormal_white_adipose1.67590802
32MP0003045_fibrosis1.65660986
33MP0002638_abnormal_pupillary_reflex1.50753540
34MP0005499_abnormal_olfactory_system1.50590192
35MP0005394_taste/olfaction_phenotype1.50590192
36MP0004885_abnormal_endolymph1.47373191
37MP0004087_abnormal_muscle_fiber1.46217624
38MP0005369_muscle_phenotype1.44205986
39MP0000013_abnormal_adipose_tissue1.42029506
40MP0001270_distended_abdomen1.40885616
41MP0004130_abnormal_muscle_cell1.37617814
42MP0005083_abnormal_biliary_tract1.34933680
43MP0002177_abnormal_outer_ear1.24233806
44MP0000372_irregular_coat_pigmentation1.23370162
45MP0003303_peritoneal_inflammation1.21721909
46MP0001905_abnormal_dopamine_level1.18974687
47MP0009379_abnormal_foot_pigmentation1.18238200
48MP0003959_abnormal_lean_body1.16601290
49MP0004233_abnormal_muscle_weight1.10732149
50MP0001873_stomach_inflammation1.10404312
51MP0005423_abnormal_somatic_nervous1.08492505
52MP0002098_abnormal_vibrissa_morphology1.05613166
53MP0002876_abnormal_thyroid_physiology1.04643002
54MP0003191_abnormal_cellular_cholesterol0.99481621
55MP0006035_abnormal_mitochondrial_morpho0.99437932
56MP0000049_abnormal_middle_ear0.98205369
57MP0003937_abnormal_limbs/digits/tail_de0.97623686
58MP0001879_abnormal_lymphatic_vessel0.96818718
59MP0002837_dystrophic_cardiac_calcinosis0.96566413
60MP0003943_abnormal_hepatobiliary_system0.94904926
61MP0005409_darkened_coat_color0.93554667
62MP0009053_abnormal_anal_canal0.93508147
63MP0004142_abnormal_muscle_tone0.93392981
64MP0005334_abnormal_fat_pad0.93255437
65MP0000538_abnormal_urinary_bladder0.93211926
66MP0002736_abnormal_nociception_after0.91502883
67MP0005408_hypopigmentation0.91448199
68MP0000427_abnormal_hair_cycle0.91112099
69MP0004185_abnormal_adipocyte_glucose0.87929178
70MP0002896_abnormal_bone_mineralization0.87831073
71MP0001881_abnormal_mammary_gland0.87764874
72MP0001346_abnormal_lacrimal_gland0.86596205
73MP0000762_abnormal_tongue_morphology0.78250478
74MP0000750_abnormal_muscle_regeneration0.75839885
75MP0002075_abnormal_coat/hair_pigmentati0.75544734
76MP0002938_white_spotting0.75094529
77MP0005174_abnormal_tail_pigmentation0.73883305
78MP0010368_abnormal_lymphatic_system0.72065165
79MP0005076_abnormal_cell_differentiation0.70654573
80MP0009250_abnormal_appendicular_skeleto0.69889125
81MP0000733_abnormal_muscle_development0.68931239
82MP0002971_abnormal_brown_adipose0.68778846
83MP0001968_abnormal_touch/_nociception0.68186670
84MP0002249_abnormal_larynx_morphology0.67654599
85MP0003880_abnormal_central_pattern0.66055853
86MP0009278_abnormal_bone_marrow0.61338273
87MP0000579_abnormal_nail_morphology0.60555814
88MP0006292_abnormal_olfactory_placode0.58588754
89MP0002114_abnormal_axial_skeleton0.54578916
90MP0003186_abnormal_redox_activity0.53832043
91MP0000631_abnormal_neuroendocrine_gland0.53414331
92MP0004270_analgesia0.51461326
93MP0000627_abnormal_mammary_gland0.50746448
94MP0003119_abnormal_digestive_system0.50382180
95MP0002069_abnormal_eating/drinking_beha0.47391889
96MP0005646_abnormal_pituitary_gland0.45946655
97MP0005636_abnormal_mineral_homeostasis0.45895936
98MP0003137_abnormal_impulse_conducting0.45736940
99MP0000467_abnormal_esophagus_morphology0.44914086
100MP0000537_abnormal_urethra_morphology0.43819758

Predicted human phenotypes

RankGene SetZ-score
1Palpebral edema (HP:0100540)6.45796428
2Mask-like facies (HP:0000298)6.15178107
3Albinism (HP:0001022)5.49843372
4Muscle hypertrophy of the lower extremities (HP:0008968)5.44563500
5Distal arthrogryposis (HP:0005684)5.15450303
6Myopathic facies (HP:0002058)5.14790265
7Myotonia (HP:0002486)5.10760691
8Nemaline bodies (HP:0003798)4.76298749
9Absent phalangeal crease (HP:0006109)4.45930750
10Split foot (HP:0001839)4.37510738
11Exercise-induced myalgia (HP:0003738)4.37079123
12Calcaneovalgus deformity (HP:0001848)4.20872152
13Hypokinesia (HP:0002375)4.19788744
14Round ear (HP:0100830)4.04645591
153-Methylglutaconic aciduria (HP:0003535)3.93110313
16Metaphyseal dysplasia (HP:0100255)3.92184301
17Muscle fiber inclusion bodies (HP:0100299)3.91912057
18Potter facies (HP:0002009)3.87214131
19Facial shape deformation (HP:0011334)3.87214131
20Ulnar deviation of the wrist (HP:0003049)3.83952268
21Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.81888398
22Deformed tarsal bones (HP:0008119)3.70558381
23Abnormal finger flexion creases (HP:0006143)3.68372686
24Absent hand (HP:0004050)3.51500377
25Hyperkalemia (HP:0002153)3.50073065
26Abnormality of the fingertips (HP:0001211)3.24392027
27Muscle stiffness (HP:0003552)3.23870971
28Decreased activity of mitochondrial respiratory chain (HP:0008972)3.21577981
29Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.21577981
30Periorbital edema (HP:0100539)3.18855030
31Neoplasm of the heart (HP:0100544)3.17392369
32Myokymia (HP:0002411)3.16252638
33Type 1 muscle fiber predominance (HP:0003803)3.15837625
34Abnormality of the parietal bone (HP:0002696)3.15725820
35Postural instability (HP:0002172)3.14792824
36Hyperphosphatemia (HP:0002905)3.12880625
37Short 4th metacarpal (HP:0010044)3.08747401
38Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.08747401
39Supernumerary ribs (HP:0005815)3.04720517
40Facial edema (HP:0000282)3.04479222
41Stomach cancer (HP:0012126)2.96823467
42Down-sloping shoulders (HP:0200021)2.89418003
43Childhood onset (HP:0011463)2.87457271
44Pancreatic cysts (HP:0001737)2.85099499
45Hip dysplasia (HP:0001385)2.81186401
46Myoglobinuria (HP:0002913)2.80811339
47Supernumerary bones of the axial skeleton (HP:0009144)2.76728668
48Methylmalonic acidemia (HP:0002912)2.75265135
49Pili torti (HP:0003777)2.65746633
50Abnormal drinking behavior (HP:0030082)2.64301414
51Polydipsia (HP:0001959)2.64301414
52Ulnar claw (HP:0001178)2.64291946
53Prolonged QT interval (HP:0001657)2.59787725
54Bell-shaped thorax (HP:0001591)2.57364969
55Pancreatic fibrosis (HP:0100732)2.55187361
56Diminished movement (HP:0002374)2.49356439
57Cystic liver disease (HP:0006706)2.39263126
58Abnormality of the 4th metacarpal (HP:0010012)2.37458614
59Exercise-induced muscle cramps (HP:0003710)2.34570397
60Absent speech (HP:0001344)2.34451636
61Viral hepatitis (HP:0006562)2.34414408
62Colon cancer (HP:0003003)2.31893407
63Increased connective tissue (HP:0009025)2.29387641
64Tubulointerstitial fibrosis (HP:0005576)2.25444119
65Ocular albinism (HP:0001107)2.24290380
66Abnormal hand bone ossification (HP:0010660)2.22832624
67Febrile seizures (HP:0002373)2.18181456
68Hyporeflexia of lower limbs (HP:0002600)2.15728685
69Neonatal respiratory distress (HP:0002643)2.12634287
70Abnormal ossification of hand bones (HP:0005921)2.10522739
71Metatarsus adductus (HP:0001840)2.07141251
72Generalized hypopigmentation (HP:0007513)2.03833277
73Congenital sensorineural hearing impairment (HP:0008527)2.00901406
74Malignant hyperthermia (HP:0002047)1.99687074
75Germ cell neoplasia (HP:0100728)1.98157644
76Medulloblastoma (HP:0002885)1.96273575
77Scanning speech (HP:0002168)1.94718063
78Neck muscle weakness (HP:0000467)1.93692392
79Enlarged kidneys (HP:0000105)1.93534998
80Iris hypopigmentation (HP:0007730)1.91367943
81Neonatal death (HP:0003811)1.90152451
82Rhinitis (HP:0012384)1.88643147
83Ragged-red muscle fibers (HP:0003200)1.86668081
84Decreased circulating renin level (HP:0003351)1.85999193
85Exertional dyspnea (HP:0002875)1.84933599
86Polyuria (HP:0000103)1.83913895
87Difficulty running (HP:0009046)1.83404638
88Decreased electroretinogram (ERG) amplitude (HP:0000654)1.83227102
89Methylmalonic aciduria (HP:0012120)1.81924257
90Ovarian neoplasm (HP:0100615)1.80341176
91Microglossia (HP:0000171)1.78011437
92Abnormality of the vitamin B12 metabolism (HP:0004341)1.76990844
93Abnormality of potassium homeostasis (HP:0011042)1.74422116
94Subacute progressive viral hepatitis (HP:0006572)1.74153607
95Neoplasm of striated muscle (HP:0009728)1.73117862
96Impaired platelet aggregation (HP:0003540)1.71403814
97Abnormal platelet function (HP:0011869)1.71403814
98Panhypogammaglobulinemia (HP:0003139)1.70688704
99Abnormality of the distal phalanx of the thumb (HP:0009617)1.70585830
100Nonprogressive disorder (HP:0003680)1.67666683

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK25.28468104
2PINK15.05753881
3CASK3.85444930
4DYRK33.34520398
5MELK3.34430715
6MAPKAPK33.17282544
7STK383.01334217
8NTRK22.89740729
9PHKG12.89545295
10PHKG22.89545295
11OBSCN2.79891872
12JAK32.76464746
13TIE12.29159231
14FGR2.20685859
15TAOK32.19652757
16EIF2AK12.01707506
17ABL21.94543290
18TYRO31.92287211
19TLK11.70088206
20CDK81.58819772
21PAK61.58776222
22STK161.35668431
23OXSR11.35314820
24WNK41.33240319
25TAOK11.32216238
26PIK3CA1.30287685
27SCYL21.24631465
28WNK11.21521191
29IRAK11.14196854
30DMPK1.09800215
31NEK61.07188561
32SGK21.06393899
33MKNK21.05052471
34STK41.03952152
35CDK190.98132654
36NLK0.96495907
37CAMK2G0.94188538
38FGFR20.92431884
39CDK40.89623530
40MAPK70.87333262
41SGK30.84329597
42MAPK130.75157466
43CDC70.75099349
44MARK10.70599056
45STK390.69308221
46RPS6KB20.66717338
47SGK10.65288766
48RPS6KA50.65247533
49DYRK1A0.64283837
50MAPK120.62210726
51EPHA20.61936044
52SGK2230.60666040
53SGK4940.60666040
54CSNK1G10.58888025
55CCNB10.58017123
56RPS6KA40.53586587
57SMG10.53080766
58PASK0.52725879
59RPS6KA20.51635920
60RPS6KL10.50485892
61RPS6KC10.50485892
62IKBKE0.48944675
63TGFBR10.48885188
64TXK0.48570643
65PRKG10.48406936
66BMPR1B0.48268899
67FRK0.47945886
68CLK10.46501969
69RPS6KA60.46104801
70NME20.45644255
71MUSK0.45639963
72EPHB20.44635888
73CAMKK20.42265110
74PKN10.41849981
75FES0.41448680
76PRKD20.39092110
77PAK30.39059835
78PIK3CG0.34188130
79CDK50.33662691
80RPS6KA10.33262949
81STK110.31680247
82PRKACA0.30334451
83HIPK20.26777710
84ABL10.23561058
85PDPK10.23510038
86INSRR0.22851973
87CAMK2D0.22321181
88CAMK1D0.21155407
89PRKACB0.20936108
90TEC0.20179046
91RPS6KA30.20044384
92PRKACG0.19741884
93CAMK40.18819060
94MAPKAPK20.18149682
95CDK180.17257059
96FGFR10.16489468
97CDK150.16443261
98IKBKB0.15868433
99CSNK1A10.15859488
100ADRBK20.14108759

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.16209219
2Tight junction_Homo sapiens_hsa045303.68112388
3Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005343.27065301
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.73664533
5Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.73136112
6Regulation of autophagy_Homo sapiens_hsa041402.56306978
7Sulfur relay system_Homo sapiens_hsa041222.39712973
8Proteasome_Homo sapiens_hsa030502.23919903
9Oxidative phosphorylation_Homo sapiens_hsa001902.16018093
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.98932141
11Nitrogen metabolism_Homo sapiens_hsa009101.95218100
12Vitamin B6 metabolism_Homo sapiens_hsa007501.91465048
13Fatty acid elongation_Homo sapiens_hsa000621.87680127
14Caffeine metabolism_Homo sapiens_hsa002321.69672790
15Collecting duct acid secretion_Homo sapiens_hsa049661.65317402
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.56770995
17Histidine metabolism_Homo sapiens_hsa003401.54839149
18Chemical carcinogenesis_Homo sapiens_hsa052041.50930126
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.48926123
20Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.42470617
21Parkinsons disease_Homo sapiens_hsa050121.42440840
22Cardiac muscle contraction_Homo sapiens_hsa042601.39495317
23TGF-beta signaling pathway_Homo sapiens_hsa043501.38394375
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.27221252
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.26607572
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.24545292
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.22894481
28Amphetamine addiction_Homo sapiens_hsa050311.20868961
29Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.20153619
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.13084454
31Starch and sucrose metabolism_Homo sapiens_hsa005001.12983667
32Hedgehog signaling pathway_Homo sapiens_hsa043401.12028019
33Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.10061336
34Insulin secretion_Homo sapiens_hsa049111.02895750
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.02768146
36Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.01980253
37Steroid hormone biosynthesis_Homo sapiens_hsa001401.01337310
38GABAergic synapse_Homo sapiens_hsa047271.01191677
39Alzheimers disease_Homo sapiens_hsa050100.95721395
40Pentose and glucuronate interconversions_Homo sapiens_hsa000400.95180895
41Folate biosynthesis_Homo sapiens_hsa007900.94614055
42cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91967167
43Peroxisome_Homo sapiens_hsa041460.91817296
44Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.90706578
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.89461929
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.89313848
47Glucagon signaling pathway_Homo sapiens_hsa049220.85246921
48Huntingtons disease_Homo sapiens_hsa050160.83101998
49Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.81916065
50Fanconi anemia pathway_Homo sapiens_hsa034600.79508876
51Circadian entrainment_Homo sapiens_hsa047130.77906268
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74105781
53Calcium signaling pathway_Homo sapiens_hsa040200.73525247
54Oxytocin signaling pathway_Homo sapiens_hsa049210.73072698
55Cocaine addiction_Homo sapiens_hsa050300.71304888
56Dopaminergic synapse_Homo sapiens_hsa047280.67527775
57AMPK signaling pathway_Homo sapiens_hsa041520.67394660
58Retinol metabolism_Homo sapiens_hsa008300.65912785
59cAMP signaling pathway_Homo sapiens_hsa040240.65365761
60Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61610708
61One carbon pool by folate_Homo sapiens_hsa006700.61364446
62Ether lipid metabolism_Homo sapiens_hsa005650.61352872
63Vibrio cholerae infection_Homo sapiens_hsa051100.61257784
64Arginine biosynthesis_Homo sapiens_hsa002200.60254529
65RNA degradation_Homo sapiens_hsa030180.59735527
66Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58921371
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58898704
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.57710343
69Olfactory transduction_Homo sapiens_hsa047400.56236865
70Circadian rhythm_Homo sapiens_hsa047100.55649555
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55298273
72Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.55172390
73Gastric acid secretion_Homo sapiens_hsa049710.54319876
74ErbB signaling pathway_Homo sapiens_hsa040120.53579900
75Cholinergic synapse_Homo sapiens_hsa047250.53468544
76Protein export_Homo sapiens_hsa030600.52928378
77Wnt signaling pathway_Homo sapiens_hsa043100.52872658
78Basal cell carcinoma_Homo sapiens_hsa052170.52141238
79Endocytosis_Homo sapiens_hsa041440.50160347
80Renin secretion_Homo sapiens_hsa049240.49116280
81Cysteine and methionine metabolism_Homo sapiens_hsa002700.48686793
82Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.48477879
83Thyroid hormone synthesis_Homo sapiens_hsa049180.48266507
84Rheumatoid arthritis_Homo sapiens_hsa053230.46039366
85Renal cell carcinoma_Homo sapiens_hsa052110.45433667
86Estrogen signaling pathway_Homo sapiens_hsa049150.43953152
87Glutamatergic synapse_Homo sapiens_hsa047240.43606049
88Morphine addiction_Homo sapiens_hsa050320.43426863
89RNA polymerase_Homo sapiens_hsa030200.41103678
90Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.39490351
91Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.37853016
92Basal transcription factors_Homo sapiens_hsa030220.37243093
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.32876638
94Insulin resistance_Homo sapiens_hsa049310.32567794
95Galactose metabolism_Homo sapiens_hsa000520.31743972
96Phototransduction_Homo sapiens_hsa047440.31305773
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.30794064
98Dilated cardiomyopathy_Homo sapiens_hsa054140.28141948
99Leukocyte transendothelial migration_Homo sapiens_hsa046700.28001906
100Nicotine addiction_Homo sapiens_hsa050330.27242524

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