ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	nucleobase catabolic process (GO:0046113)	9.23597302
2	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	5.13971365
3	mitochondrial respiratory chain complex I assembly (GO:0032981)	5.13971365
4	NADH dehydrogenase complex assembly (GO:0010257)	5.13971365
5	layer formation in cerebral cortex (GO:0021819)	4.88694710
6	pyrimidine nucleoside monophosphate metabolic process (GO:0009129)	4.86864095
7	pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)	4.84756014
8	UMP metabolic process (GO:0046049)	4.84756014
9	pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)	4.84756014
10	UMP biosynthetic process (GO:0006222)	4.84756014
11	pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)	4.68295310
12	retinal ganglion cell axon guidance (GO:0031290)	4.34838966
13	protein complex biogenesis (GO:0070271)	4.26525325
14	transcription elongation from RNA polymerase III promoter (GO:0006385)	4.24013478
15	termination of RNA polymerase III transcription (GO:0006386)	4.24013478
16	mitochondrial respiratory chain complex assembly (GO:0033108)	4.22538054
17	glycosphingolipid biosynthetic process (GO:0006688)	4.09073296
18	pyrimidine ribonucleoside biosynthetic process (GO:0046132)	4.06678685
19	regulation of feeding behavior (GO:0060259)	4.06076270
20	central nervous system projection neuron axonogenesis (GO:0021952)	3.97233743
21	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.93096784
22	dendritic spine morphogenesis (GO:0060997)	3.90937020
23	chaperone-mediated protein transport (GO:0072321)	3.89420513
24	acrosome assembly (GO:0001675)	3.88378788
25	atrial cardiac muscle cell action potential (GO:0086014)	3.86691997
26	pyrimidine ribonucleotide biosynthetic process (GO:0009220)	3.85899331
27	GTP biosynthetic process (GO:0006183)	3.79233244
28	pyrimidine ribonucleotide metabolic process (GO:0009218)	3.77910808
29	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	3.75007547
30	behavioral response to nicotine (GO:0035095)	3.65777515
31	prenylation (GO:0097354)	3.61042633
32	protein prenylation (GO:0018342)	3.61042633
33	pyrimidine nucleotide biosynthetic process (GO:0006221)	3.57926503
34	rRNA catabolic process (GO:0016075)	3.57794293
35	sialylation (GO:0097503)	3.57031481
36	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.54065960
37	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.51411224
38	ATP synthesis coupled proton transport (GO:0015986)	3.51411224
39	UTP biosynthetic process (GO:0006228)	3.45757081
40	protein neddylation (GO:0045116)	3.45093330
41	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	3.42784175
42	CTP metabolic process (GO:0046036)	3.42767155
43	CTP biosynthetic process (GO:0006241)	3.42767155
44	pyrimidine nucleobase metabolic process (GO:0006206)	3.39042143
45	UTP metabolic process (GO:0046051)	3.35460234
46	peptidyl-histidine modification (GO:0018202)	3.33066998
47	glycerophospholipid catabolic process (GO:0046475)	3.30562310
48	pyrimidine-containing compound catabolic process (GO:0072529)	3.29899747
49	protein targeting to mitochondrion (GO:0006626)	3.28404105
50	positive regulation of prostaglandin secretion (GO:0032308)	3.26847257
51	kinetochore assembly (GO:0051382)	3.24285530
52	pyrimidine ribonucleoside metabolic process (GO:0046131)	3.21677203
53	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	3.20615820
54	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.17522985
55	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.17522985
56	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	3.14351894
57	regulation of hexokinase activity (GO:1903299)	3.13925946
58	regulation of glucokinase activity (GO:0033131)	3.13925946
59	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	3.11593046
60	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	3.08414563
61	cellular response to cholesterol (GO:0071397)	3.08314022
62	positive regulation of dendritic spine morphogenesis (GO:0061003)	3.07035116
63	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.06213391
64	DNA replication-dependent nucleosome organization (GO:0034723)	3.04765777
65	DNA replication-dependent nucleosome assembly (GO:0006335)	3.04765777
66	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.03513120
67	pyrimidine nucleoside biosynthetic process (GO:0046134)	3.02204572
68	grooming behavior (GO:0007625)	2.99978243
69	nucleoside diphosphate phosphorylation (GO:0006165)	2.99430810
70	establishment of protein localization to mitochondrion (GO:0072655)	2.97349753
71	anterograde synaptic vesicle transport (GO:0048490)	2.95679487
72	respiratory chain complex IV assembly (GO:0008535)	2.95675226
73	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.95130761
74	central nervous system neuron axonogenesis (GO:0021955)	2.94001168
75	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.93665639
76	transmission of nerve impulse (GO:0019226)	2.92906823
77	regulation of cilium movement (GO:0003352)	2.91874346
78	pyrimidine nucleotide metabolic process (GO:0006220)	2.91421389
79	DNA deamination (GO:0045006)	2.90632574
80	chromatin remodeling at centromere (GO:0031055)	2.88084847
81	proteasome assembly (GO:0043248)	2.86665452
82	dendritic spine organization (GO:0097061)	2.85385519
83	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.85300426
84	establishment of mitochondrion localization (GO:0051654)	2.85291103
85	response to methylmercury (GO:0051597)	2.84348583
86	regulation of synapse structural plasticity (GO:0051823)	2.82195048
87	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	2.81208596
88	mitochondrion transport along microtubule (GO:0047497)	2.81208596
89	transcription from RNA polymerase III promoter (GO:0006383)	2.81041863
90	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.80381133
91	CENP-A containing nucleosome assembly (GO:0034080)	2.79934189
92	protein localization to mitochondrion (GO:0070585)	2.79509320
93	protein-cofactor linkage (GO:0018065)	2.74046578
94	pyrimidine-containing compound biosynthetic process (GO:0072528)	2.70630221
95	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.69798945
96	regulation of prostaglandin secretion (GO:0032306)	2.69290126
97	nucleoside triphosphate biosynthetic process (GO:0009142)	2.68928946
98	ATP biosynthetic process (GO:0006754)	2.68572082
99	regulation of microtubule-based movement (GO:0060632)	2.67318411
100	pyrimidine nucleobase catabolic process (GO:0006208)	11.6099747

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.05041426
2	EZH2_22144423_ChIP-Seq_EOC_Human	4.04313189
3	RBPJ_22232070_ChIP-Seq_NCS_Mouse	3.55042038
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.54450936
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.08036894
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.96600872
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.85142001
8	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.56622159
9	EWS_26573619_Chip-Seq_HEK293_Human	2.51369214
10	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.40558936
11	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.32646246
12	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.32631909
13	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.30880314
14	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.21444739
15	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.15683146
16	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.07413847
17	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.05103992
18	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.03173108
19	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.99702054
20	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.90819868
21	MYC_18940864_ChIP-ChIP_HL60_Human	1.89953658
22	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.89047157
23	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.85731322
24	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.84074033
25	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.82591825
26	P300_19829295_ChIP-Seq_ESCs_Human	1.81087822
27	VDR_22108803_ChIP-Seq_LS180_Human	1.79949954
28	ELK1_19687146_ChIP-ChIP_HELA_Human	1.75178980
29	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.74938204
30	FUS_26573619_Chip-Seq_HEK293_Human	1.70246143
31	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.69946225
32	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.69837644
33	RNF2_27304074_Chip-Seq_NSC_Mouse	1.69672710
34	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.63262339
35	VDR_23849224_ChIP-Seq_CD4+_Human	1.58393811
36	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.58270010
37	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.57921704
38	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.57856797
39	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.54498075
40	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.52513771
41	GBX2_23144817_ChIP-Seq_PC3_Human	1.48510326
42	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.47383038
43	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.46036726
44	IRF1_19129219_ChIP-ChIP_H3396_Human	1.44829843
45	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.43693357
46	TP53_22573176_ChIP-Seq_HFKS_Human	1.42925240
47	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.40893650
48	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.39532110
49	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.38624612
50	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.37414683
51	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.34661607
52	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.30939293
53	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.30698962
54	IGF1R_20145208_ChIP-Seq_DFB_Human	1.29493086
55	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.28069660
56	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.27535176
57	GABP_19822575_ChIP-Seq_HepG2_Human	1.25724538
58	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.24937017
59	TAF15_26573619_Chip-Seq_HEK293_Human	1.24312004
60	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.21542758
61	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.15975805
62	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.14911197
63	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.13391796
64	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.13165341
65	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.12732669
66	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.12389067
67	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.12135881
68	EGR1_19032775_ChIP-ChIP_M12_Human	1.10847064
69	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.06479653
70	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.06100265
71	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.05907099
72	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.04998575
73	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.04281962
74	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.02793660
75	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.01833883
76	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.01565579
77	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.00979247
78	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.00898397
79	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.00572426
80	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.98336708
81	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.97434552
82	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.97149807
83	NCOR_22424771_ChIP-Seq_293T_Human	0.96955034
84	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.95790009
85	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.94934490
86	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.93434885
87	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.92657571
88	TCF4_22108803_ChIP-Seq_LS180_Human	0.92350181
89	POU5F1_18347094_ChIP-ChIP_MESCs_Mouse	0.92256974
90	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.92179619
91	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.92075655
92	FOXP3_21729870_ChIP-Seq_TREG_Human	0.91372619
93	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.91351933
94	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.91107491
95	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.89423177
96	SMAD4_21799915_ChIP-Seq_A2780_Human	0.87515482
97	DCP1A_22483619_ChIP-Seq_HELA_Human	0.86581170
98	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.86546908
99	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.86489764
100	POU3F1_26484290_ChIP-Seq_ESCss_Mouse	0.85868161

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	4.35341088
2	MP0003011_delayed_dark_adaptation	3.57036989
3	MP0004859_abnormal_synaptic_plasticity	3.25326262
4	MP0006054_spinal_hemorrhage	3.15259386
5	MP0005645_abnormal_hypothalamus_physiol	3.00668806
6	MP0001529_abnormal_vocalization	2.88363427
7	MP0008872_abnormal_physiological_respon	2.56435933
8	MP0005083_abnormal_biliary_tract	2.48919516
9	MP0008789_abnormal_olfactory_epithelium	2.37533544
10	MP0005367_renal/urinary_system_phenotyp	2.24664582
11	MP0000516_abnormal_urinary_system	2.24664582
12	MP0005084_abnormal_gallbladder_morpholo	2.22713608
13	MP0000778_abnormal_nervous_system	2.20659286
14	MP0002160_abnormal_reproductive_system	2.08625040
15	MP0005394_taste/olfaction_phenotype	2.02229161
16	MP0005499_abnormal_olfactory_system	2.02229161
17	MP0006276_abnormal_autonomic_nervous	2.00523815
18	MP0002102_abnormal_ear_morphology	1.92150475
19	MP0002163_abnormal_gland_morphology	1.90091946
20	MP0003137_abnormal_impulse_conducting	1.83525590
21	MP0002254_reproductive_system_inflammat	1.77777341
22	MP0004145_abnormal_muscle_electrophysio	1.72917136
23	MP0002184_abnormal_innervation	1.71359551
24	MP0000749_muscle_degeneration	1.67646395
25	MP0005389_reproductive_system_phenotype	1.64797572
26	MP0004142_abnormal_muscle_tone	1.58792026
27	MP0006292_abnormal_olfactory_placode	1.54318985
28	MP0001984_abnormal_olfaction	1.52260247
29	MP0008775_abnormal_heart_ventricle	1.49220715
30	MP0000049_abnormal_middle_ear	1.46174788
31	MP0002282_abnormal_trachea_morphology	1.42310264
32	MP0002277_abnormal_respiratory_mucosa	1.41771905
33	MP0005257_abnormal_intraocular_pressure	1.39486813
34	MP0001486_abnormal_startle_reflex	1.39335741
35	MP0003635_abnormal_synaptic_transmissio	1.38291544
36	MP0009697_abnormal_copulation	1.38036289
37	MP0005551_abnormal_eye_electrophysiolog	1.34078584
38	MP0002909_abnormal_adrenal_gland	1.33577703
39	MP0002233_abnormal_nose_morphology	1.32567137
40	MP0000372_irregular_coat_pigmentation	1.32437390
41	MP0002735_abnormal_chemical_nociception	1.31471799
42	MP0005187_abnormal_penis_morphology	1.30618125
43	MP0003186_abnormal_redox_activity	1.30153910
44	MP0002938_white_spotting	1.30091174
45	MP0009745_abnormal_behavioral_response	1.27096029
46	MP0002063_abnormal_learning/memory/cond	1.25242891
47	MP0004043_abnormal_pH_regulation	1.23574007
48	MP0008995_early_reproductive_senescence	1.19808610
49	MP0004924_abnormal_behavior	1.18040083
50	MP0005386_behavior/neurological_phenoty	1.18040083
51	MP0000955_abnormal_spinal_cord	1.14865051
52	MP0001177_atelectasis	1.10877291
53	MP0002876_abnormal_thyroid_physiology	1.09351404
54	MP0006036_abnormal_mitochondrial_physio	1.05236716
55	MP0005379_endocrine/exocrine_gland_phen	1.03567908
56	MP0002210_abnormal_sex_determination	1.02737465
57	MP0002751_abnormal_autonomic_nervous	1.02564816
58	MP0001919_abnormal_reproductive_system	1.02527781
59	MP0002752_abnormal_somatic_nervous	1.01376302
60	MP0002127_abnormal_cardiovascular_syste	0.99795151
61	MP0003718_maternal_effect	0.94825450
62	MP0003698_abnormal_male_reproductive	0.94499220
63	MP0001764_abnormal_homeostasis	0.93775671
64	MP0005423_abnormal_somatic_nervous	0.93139536
65	MP0004085_abnormal_heartbeat	0.92687353
66	MP0002572_abnormal_emotion/affect_behav	0.92259861
67	MP0002234_abnormal_pharynx_morphology	0.88445930
68	MP0003279_aneurysm	0.88406138
69	MP0003755_abnormal_palate_morphology	0.87776320
70	MP0003786_premature_aging	0.87309942
71	MP0001485_abnormal_pinna_reflex	0.86203119
72	MP0001542_abnormal_bone_strength	0.85594328
73	MP0002822_catalepsy	0.85360684
74	MP0001145_abnormal_male_reproductive	0.85191633
75	MP0002067_abnormal_sensory_capabilities	0.85139012
76	MP0002733_abnormal_thermal_nociception	0.84207658
77	MP0001270_distended_abdomen	0.82714946
78	MP0008007_abnormal_cellular_replicative	0.81571045
79	MP0003111_abnormal_nucleus_morphology	0.81177875
80	MP0001970_abnormal_pain_threshold	0.80625944
81	MP0003077_abnormal_cell_cycle	0.80059262
82	MP0003806_abnormal_nucleotide_metabolis	0.80022408
83	MP0002734_abnormal_mechanical_nocicepti	0.79992886
84	MP0001929_abnormal_gametogenesis	0.79492059
85	MP0005253_abnormal_eye_physiology	0.79139450
86	MP0000343_altered_response_to	0.78974506
87	MP0000653_abnormal_sex_gland	0.78826000
88	MP0002837_dystrophic_cardiac_calcinosis	0.78150546
89	MP0002736_abnormal_nociception_after	0.77479948
90	MP0006035_abnormal_mitochondrial_morpho	0.77433777
91	MP0005646_abnormal_pituitary_gland	0.76292953
92	MP0002882_abnormal_neuron_morphology	0.75650740
93	MP0004885_abnormal_endolymph	0.74655516
94	MP0000631_abnormal_neuroendocrine_gland	0.73939604
95	MP0002152_abnormal_brain_morphology	0.73332950
96	MP0002069_abnormal_eating/drinking_beha	0.72168226
97	MP0004811_abnormal_neuron_physiology	0.71004695
98	MP0000647_abnormal_sebaceous_gland	0.70980441
99	MP0005195_abnormal_posterior_eye	0.69857376
100	MP0002177_abnormal_outer_ear	0.69854763

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Multiple enchondromatosis (HP:0005701)	5.37788422
2	Acute necrotizing encephalopathy (HP:0006965)	3.93566531
3	Abnormality of pyrimidine metabolism (HP:0004353)	3.92784773
4	Type 2 muscle fiber atrophy (HP:0003554)	3.68390554
5	Tetraplegia (HP:0002445)	3.66364245
6	Progressive macrocephaly (HP:0004481)	3.48611461
7	Myokymia (HP:0002411)	3.44009870
8	Acute encephalopathy (HP:0006846)	3.42422793
9	Abnormality of the aortic arch (HP:0012303)	3.35657076
10	Increased CSF lactate (HP:0002490)	3.33094900
11	Muscle fiber atrophy (HP:0100295)	3.28228453
12	Mitochondrial inheritance (HP:0001427)	3.25867386
13	Abnormal mitochondria in muscle tissue (HP:0008316)	3.25433302
14	Hyperglycinemia (HP:0002154)	3.23158518
15	3-Methylglutaconic aciduria (HP:0003535)	3.17197006
16	Hepatocellular necrosis (HP:0001404)	3.04876208
17	Abnormality of the labia minora (HP:0012880)	2.98760699
18	Tubulointerstitial nephritis (HP:0001970)	2.85454737
19	Increased serum pyruvate (HP:0003542)	2.85133884
20	Cerebral edema (HP:0002181)	2.80667834
21	Pachygyria (HP:0001302)	2.78811012
22	Hypoplastic pelvis (HP:0008839)	2.76053074
23	Lissencephaly (HP:0001339)	2.65642491
24	Genetic anticipation (HP:0003743)	2.65287000
25	Type I transferrin isoform profile (HP:0003642)	2.65000818
26	Hepatic necrosis (HP:0002605)	2.63476440
27	Hypomagnesemia (HP:0002917)	2.54701796
28	Intestinal atresia (HP:0011100)	2.52519753
29	Decreased central vision (HP:0007663)	2.47392566
30	Respiratory failure (HP:0002878)	2.40467089
31	Retinal dysplasia (HP:0007973)	2.38512108
32	Abnormality of glycolysis (HP:0004366)	2.38285619
33	Optic disc pallor (HP:0000543)	2.35952331
34	Cleft eyelid (HP:0000625)	2.34872202
35	Poor eye contact (HP:0000817)	2.34803145
36	Lethargy (HP:0001254)	2.31823972
37	Pancreatic fibrosis (HP:0100732)	2.31609036
38	Ectopic kidney (HP:0000086)	2.30668512
39	Focal seizures (HP:0007359)	2.27845072
40	Gaze-evoked nystagmus (HP:0000640)	2.25923440
41	Agitation (HP:0000713)	2.23460279
42	Patellar aplasia (HP:0006443)	2.23301556
43	Aplasia/Hypoplasia of the patella (HP:0006498)	2.21073481
44	Progressive inability to walk (HP:0002505)	2.20594955
45	Oligodactyly (hands) (HP:0001180)	2.20558585
46	Muscular hypotonia of the trunk (HP:0008936)	2.20367169
47	Prolonged QT interval (HP:0001657)	2.19684482
48	Inability to walk (HP:0002540)	2.18597069
49	Abnormality of magnesium homeostasis (HP:0004921)	2.18466975
50	Methylmalonic acidemia (HP:0002912)	2.16847315
51	Abnormality of nucleobase metabolism (HP:0010932)	2.15141145
52	Trismus (HP:0000211)	2.13663388
53	Gastrointestinal atresia (HP:0002589)	2.13645866
54	Pendular nystagmus (HP:0012043)	2.12789026
55	Keratoconus (HP:0000563)	2.11680300
56	Increased corneal curvature (HP:0100692)	2.11680300
57	Stenosis of the external auditory canal (HP:0000402)	2.11268935
58	Short tibia (HP:0005736)	2.10238101
59	Neonatal respiratory distress (HP:0002643)	2.09212793
60	Abnormality of alanine metabolism (HP:0010916)	2.09108974
61	Hyperalaninemia (HP:0003348)	2.09108974
62	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.09108974
63	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.08470710
64	Hypoplasia of the capital femoral epiphysis (HP:0003090)	2.05671425
65	Methylmalonic aciduria (HP:0012120)	2.03760234
66	Flat capital femoral epiphysis (HP:0003370)	2.03393132
67	Pancreatic cysts (HP:0001737)	2.01979554
68	Oligodactyly (HP:0012165)	2.01667328
69	Amniotic constriction ring (HP:0009775)	2.01579301
70	Abnormality of placental membranes (HP:0011409)	2.01579301
71	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.98470864
72	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.98470864
73	Focal motor seizures (HP:0011153)	1.98177152
74	CNS hypomyelination (HP:0003429)	1.96994143
75	Increased serum lactate (HP:0002151)	1.96877780
76	Renal hypoplasia (HP:0000089)	1.95356870
77	Metaphyseal dysplasia (HP:0100255)	1.94342610
78	Hypsarrhythmia (HP:0002521)	1.93645051
79	Polyuria (HP:0000103)	1.92572258
80	Wrist flexion contracture (HP:0001239)	1.90024365
81	Abnormality of glycine metabolism (HP:0010895)	1.87493632
82	Abnormality of serine family amino acid metabolism (HP:0010894)	1.87493632
83	Lactic acidosis (HP:0003128)	1.87445582
84	Broad-based gait (HP:0002136)	1.87231057
85	Meningioma (HP:0002858)	1.83660575
86	Abnormal protein glycosylation (HP:0012346)	1.83245510
87	Abnormal glycosylation (HP:0012345)	1.83245510
88	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.83245510
89	Abnormal protein N-linked glycosylation (HP:0012347)	1.83245510
90	Popliteal pterygium (HP:0009756)	1.81412727
91	Glossoptosis (HP:0000162)	1.81294279
92	Concave nail (HP:0001598)	1.81061112
93	Disproportionate short-trunk short stature (HP:0003521)	1.79977506
94	CNS demyelination (HP:0007305)	1.79958279
95	Delayed CNS myelination (HP:0002188)	1.79542379
96	Reduced antithrombin III activity (HP:0001976)	1.78358241
97	Supernumerary spleens (HP:0009799)	1.77559461
98	Increased purine levels (HP:0004368)	1.77039577
99	Hyperuricemia (HP:0002149)	1.77039577
100	Tented upper lip vermilion (HP:0010804)	1.76236289

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	4.21050085
2	BMPR1B	4.06905921
3	ACVR1B	3.12201683
4	EPHA4	3.09301957
5	CCNB1	3.00019016
6	EPHB2	2.52660386
7	EIF2AK3	2.45770012
8	MAP3K12	2.30346236
9	CDK8	2.26677512
10	ERBB3	2.16838189
11	TRIM28	2.09079068
12	MARK1	2.07582873
13	DYRK2	2.05090082
14	BCKDK	2.04319392
15	FRK	1.90939949
16	CAMKK2	1.87302236
17	TIE1	1.80503720
18	TGFBR1	1.69486908
19	ZAK	1.63758786
20	EIF2AK1	1.63171563
21	VRK1	1.41522565
22	VRK2	1.40085251
23	PAK3	1.38589621
24	WNK3	1.34026631
25	CLK1	1.24810744
26	STK16	1.24729836
27	PLK4	1.24396148
28	DAPK2	1.23093421
29	PDK2	1.22093805
30	PINK1	1.18403274
31	CSNK1G2	1.18168422
32	GRK1	1.14928165
33	MKNK2	1.13985466
34	UHMK1	1.10512888
35	ADRBK2	1.09054861
36	ADRBK1	1.06578614
37	BCR	1.04315671
38	CSNK1G3	1.03539876
39	MUSK	1.02264053
40	TYRO3	1.00989959
41	CASK	1.00091440
42	NEK1	0.98354712
43	MAP3K4	0.97748413
44	MST4	0.93738543
45	PLK2	0.88329725
46	PRKD3	0.88242218
47	CSNK1A1L	0.84852975
48	MINK1	0.84478158
49	LRRK2	0.84117763
50	MKNK1	0.80887933
51	DAPK3	0.79054990
52	BRSK1	0.75157095
53	CSNK1G1	0.74027923
54	PLK3	0.70657177
55	FER	0.69822980
56	WEE1	0.68691920
57	DYRK3	0.68390893
58	CDC7	0.68083700
59	BUB1	0.68034112
60	MAPK13	0.67590397
61	STK10	0.67149947
62	NME2	0.66959985
63	CAMK1	0.65249649
64	STK3	0.65191328
65	CAMK4	0.62929598
66	PLK1	0.61232088
67	NTRK2	0.59072977
68	TLK1	0.58970830
69	RPS6KA5	0.58947776
70	PIK3CA	0.57680134
71	DAPK1	0.54494350
72	AURKB	0.54029513
73	RPS6KA4	0.53469085
74	MELK	0.53225108
75	CAMKK1	0.50205655
76	PRKCE	0.49032551
77	ROCK2	0.48833731
78	ROCK1	0.48658485
79	OXSR1	0.46838290
80	PRKD2	0.46829802
81	ILK	0.46227071
82	OBSCN	0.44814401
83	FES	0.43532577
84	ERBB4	0.43223655
85	PRKACA	0.42653582
86	AURKA	0.42230340
87	INSRR	0.41379288
88	PRKCG	0.41091293
89	PHKG1	0.40381386
90	PHKG2	0.40381386
91	CDK5	0.38947884
92	RPS6KA1	0.37035279
93	STK11	0.36143544
94	MAP2K1	0.35788309
95	CSNK2A2	0.34353573
96	MAP2K4	0.34079968
97	PKN1	0.33793550
98	YES1	0.33405658
99	MAP3K8	0.31788085
100	ERBB2	0.31625572

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	4.21276581
2	Sulfur relay system_Homo sapiens_hsa04122	3.36150300
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.17789514
4	RNA polymerase_Homo sapiens_hsa03020	3.15578204
5	Parkinsons disease_Homo sapiens_hsa05012	2.98745872
6	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.32656424
7	Pyrimidine metabolism_Homo sapiens_hsa00240	2.28847692
8	Propanoate metabolism_Homo sapiens_hsa00640	2.23937598
9	Huntingtons disease_Homo sapiens_hsa05016	2.17035152
10	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.12120885
11	beta-Alanine metabolism_Homo sapiens_hsa00410	2.03086925
12	Ribosome_Homo sapiens_hsa03010	1.97501325
13	Butanoate metabolism_Homo sapiens_hsa00650	1.95387844
14	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.92138493
15	Alzheimers disease_Homo sapiens_hsa05010	1.91984712
16	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.84446645
17	Proteasome_Homo sapiens_hsa03050	1.67364087
18	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.65125925
19	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.63374590
20	Steroid biosynthesis_Homo sapiens_hsa00100	1.61748480
21	Fanconi anemia pathway_Homo sapiens_hsa03460	1.52100477
22	Protein export_Homo sapiens_hsa03060	1.50736379
23	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.50599816
24	Homologous recombination_Homo sapiens_hsa03440	1.49918314
25	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.45474605
26	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.45469038
27	Peroxisome_Homo sapiens_hsa04146	1.42022088
28	Basal transcription factors_Homo sapiens_hsa03022	1.41957362
29	Linoleic acid metabolism_Homo sapiens_hsa00591	1.40396696
30	Alcoholism_Homo sapiens_hsa05034	1.36279710
31	Phototransduction_Homo sapiens_hsa04744	1.36228556
32	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.34010920
33	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.25658861
34	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.23588589
35	Ether lipid metabolism_Homo sapiens_hsa00565	1.23183853
36	RNA transport_Homo sapiens_hsa03013	1.23078245
37	Purine metabolism_Homo sapiens_hsa00230	1.19046625
38	RNA degradation_Homo sapiens_hsa03018	1.16347518
39	Cardiac muscle contraction_Homo sapiens_hsa04260	1.16123572
40	Axon guidance_Homo sapiens_hsa04360	1.10978025
41	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.08803153
42	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.07950082
43	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.04917009
44	Nicotine addiction_Homo sapiens_hsa05033	1.02403956
45	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.00816302
46	One carbon pool by folate_Homo sapiens_hsa00670	0.97422159
47	Base excision repair_Homo sapiens_hsa03410	0.95179456
48	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.87255902
49	Tryptophan metabolism_Homo sapiens_hsa00380	0.87042639
50	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.82887294
51	Pyruvate metabolism_Homo sapiens_hsa00620	0.82024297
52	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.81884395
53	Nitrogen metabolism_Homo sapiens_hsa00910	0.81049619
54	Metabolic pathways_Homo sapiens_hsa01100	0.75972622
55	Retinol metabolism_Homo sapiens_hsa00830	0.74769252
56	Insulin secretion_Homo sapiens_hsa04911	0.73327390
57	Spliceosome_Homo sapiens_hsa03040	0.73150006
58	Collecting duct acid secretion_Homo sapiens_hsa04966	0.70133263
59	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.69864161
60	Regulation of autophagy_Homo sapiens_hsa04140	0.69792287
61	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.69276354
62	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.68808198
63	Non-homologous end-joining_Homo sapiens_hsa03450	0.68747245
64	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.68286178
65	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.67524052
66	Folate biosynthesis_Homo sapiens_hsa00790	0.64764720
67	Cocaine addiction_Homo sapiens_hsa05030	0.62124778
68	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.61994660
69	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.53674531
70	DNA replication_Homo sapiens_hsa03030	0.51480328
71	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.50715880
72	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.50196293
73	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.47806951
74	Circadian entrainment_Homo sapiens_hsa04713	0.46519310
75	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.45811404
76	Cholinergic synapse_Homo sapiens_hsa04725	0.43067649
77	Selenocompound metabolism_Homo sapiens_hsa00450	0.42923208
78	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.42445538
79	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.41741801
80	Mismatch repair_Homo sapiens_hsa03430	0.40756592
81	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.38552847
82	Glycerolipid metabolism_Homo sapiens_hsa00561	0.38516802
83	Fatty acid elongation_Homo sapiens_hsa00062	0.38451723
84	Salivary secretion_Homo sapiens_hsa04970	0.38209855
85	Gastric acid secretion_Homo sapiens_hsa04971	0.37834479
86	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.35307173
87	Olfactory transduction_Homo sapiens_hsa04740	0.34113117
88	Arginine and proline metabolism_Homo sapiens_hsa00330	0.33549695
89	Serotonergic synapse_Homo sapiens_hsa04726	0.33432304
90	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.30460974
91	Amphetamine addiction_Homo sapiens_hsa05031	0.29683278
92	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.29110527
93	Glutamatergic synapse_Homo sapiens_hsa04724	0.27618193
94	Wnt signaling pathway_Homo sapiens_hsa04310	0.27087823
95	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.27082006
96	Fat digestion and absorption_Homo sapiens_hsa04975	0.26032098
97	Nucleotide excision repair_Homo sapiens_hsa03420	0.25855284
98	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.25590729
99	GABAergic synapse_Homo sapiens_hsa04727	0.25199528
100	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.25105669

SNRPGP9

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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