SNRPN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is located within the Prader-Willi Syndrome critical region on chromosome 15 and is imprinted and expressed from the paternal allele. It encodes a component of the small nuclear ribonucleoprotein complex, which functions in pre-mRNA processing and may contribute to tissue-specific alternative splicing. Alternative promoter use and alternative splicing result in a multitude of transcript variants encoding the same protein. Transcript variants that initiate at the CpG island-associated imprinting center may be bicistronic and also encode the SNRPN upstream reading frame protein (SNURF) from an upstream open reading frame. In addition, long spliced transcripts for small nucleolar RNA host gene 14 (SNHG14) may originate from the promoters at this locus and share exons with this gene. Alterations in this region are associated with parental imprint switch failure, which may cause Angelman syndrome or Prader-Willi syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)6.07368021
2synaptic vesicle docking involved in exocytosis (GO:0016081)5.88540257
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.68162838
4glutamate secretion (GO:0014047)5.64570288
5regulation of synaptic vesicle exocytosis (GO:2000300)5.42981460
6vocalization behavior (GO:0071625)5.42159886
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.28639705
8regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.14114982
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.06197070
10neuron cell-cell adhesion (GO:0007158)4.98579647
11synaptic vesicle maturation (GO:0016188)4.97910936
12regulation of glutamate receptor signaling pathway (GO:1900449)4.94885211
13neuronal action potential propagation (GO:0019227)4.93326954
14neurotransmitter-gated ion channel clustering (GO:0072578)4.93069650
15neurotransmitter secretion (GO:0007269)4.79899405
16protein localization to synapse (GO:0035418)4.78425974
17regulation of synaptic vesicle transport (GO:1902803)4.73170618
18locomotory exploration behavior (GO:0035641)4.42229767
19negative regulation of synaptic transmission, GABAergic (GO:0032229)4.41405230
20neuron-neuron synaptic transmission (GO:0007270)4.39477527
21positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.36407989
22presynaptic membrane assembly (GO:0097105)4.36392192
23synaptic transmission, glutamatergic (GO:0035249)4.27378865
24ionotropic glutamate receptor signaling pathway (GO:0035235)4.23847600
25presynaptic membrane organization (GO:0097090)4.16135550
26membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.10328874
27transferrin transport (GO:0033572)4.05455210
28energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.02991993
29ATP hydrolysis coupled proton transport (GO:0015991)4.02991993
30postsynaptic membrane organization (GO:0001941)4.02574573
31regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.94936817
32gamma-aminobutyric acid signaling pathway (GO:0007214)3.90208680
33gamma-aminobutyric acid transport (GO:0015812)3.88838893
34negative regulation of dendrite morphogenesis (GO:0050774)3.87848686
35glutamate receptor signaling pathway (GO:0007215)3.86842249
36positive regulation of synapse maturation (GO:0090129)3.80722418
37long-term synaptic potentiation (GO:0060291)3.79680721
38neurotransmitter transport (GO:0006836)3.78171871
39trivalent inorganic cation transport (GO:0072512)3.76729195
40ferric iron transport (GO:0015682)3.76729195
41regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.69204970
42positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.68354171
43regulation of neuronal synaptic plasticity (GO:0048168)3.66100409
44negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.65188482
45exploration behavior (GO:0035640)3.64524234
46regulation of excitatory postsynaptic membrane potential (GO:0060079)3.60977432
47regulation of neurotransmitter secretion (GO:0046928)3.57395856
48positive regulation of membrane potential (GO:0045838)3.55940683
49regulation of long-term neuronal synaptic plasticity (GO:0048169)3.55341215
50positive regulation of neurotransmitter transport (GO:0051590)3.53813191
51cerebellar Purkinje cell differentiation (GO:0021702)3.52650789
52regulation of synaptic transmission, glutamatergic (GO:0051966)3.52514919
53regulation of neurotransmitter levels (GO:0001505)3.52134362
54cerebellar granule cell differentiation (GO:0021707)3.50554850
55proline transport (GO:0015824)3.50424857
56positive regulation of synaptic transmission, GABAergic (GO:0032230)3.50155339
57startle response (GO:0001964)3.48674039
58neuromuscular process controlling posture (GO:0050884)3.44624060
59regulation of postsynaptic membrane potential (GO:0060078)3.44337844
60regulation of synapse structural plasticity (GO:0051823)3.43582397
61response to histamine (GO:0034776)3.40105193
62L-serine metabolic process (GO:0006563)3.39577985
63regulation of synaptic plasticity (GO:0048167)3.37981595
64regulation of neurotransmitter transport (GO:0051588)3.37928269
65protein neddylation (GO:0045116)3.30501907
66synaptic vesicle endocytosis (GO:0048488)3.28786725
67long-term memory (GO:0007616)3.26857993
68negative regulation of dendrite development (GO:2000171)3.24180601
69mechanosensory behavior (GO:0007638)3.24123077
70neurotransmitter uptake (GO:0001504)3.23627035
71positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.22357248
72positive regulation of synaptic transmission (GO:0050806)3.21793454
73activation of protein kinase A activity (GO:0034199)3.20273204
74synaptic transmission (GO:0007268)3.19190721
75positive regulation of synapse assembly (GO:0051965)3.17141087
76establishment of integrated proviral latency (GO:0075713)3.16991811
77regulation of synaptic transmission, GABAergic (GO:0032228)3.15962921
78pyrimidine nucleobase catabolic process (GO:0006208)3.15585486
79DNA double-strand break processing (GO:0000729)3.15158045
80regulation of synapse maturation (GO:0090128)3.14311567
81G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.12412692
82NADH metabolic process (GO:0006734)3.10562354
83membrane depolarization during action potential (GO:0086010)3.10520934
84positive regulation of neurotransmitter secretion (GO:0001956)3.09537217
85behavioral response to cocaine (GO:0048148)3.09163932
86neuron recognition (GO:0008038)3.08632483
87membrane depolarization (GO:0051899)3.07972723
88regulation of gene silencing by RNA (GO:0060966)3.07142401
89regulation of posttranscriptional gene silencing (GO:0060147)3.07142401
90regulation of gene silencing by miRNA (GO:0060964)3.07142401
91regulation of synaptic transmission (GO:0050804)3.04417590
92striatum development (GO:0021756)3.04349970
93regulation of vesicle fusion (GO:0031338)3.03364814
94membrane hyperpolarization (GO:0060081)3.01379346
95behavioral fear response (GO:0001662)3.01204113
96behavioral defense response (GO:0002209)3.01204113
97regulation of glutamate secretion (GO:0014048)3.01070036
98establishment of synaptic vesicle localization (GO:0097480)3.00802860
99synaptic vesicle transport (GO:0048489)3.00802860
100chaperone-mediated protein transport (GO:0072321)3.00797070
101water-soluble vitamin biosynthetic process (GO:0042364)2.98359151
102auditory behavior (GO:0031223)2.98243128
103regulation of voltage-gated calcium channel activity (GO:1901385)2.97061787
104cell migration in hindbrain (GO:0021535)2.95790279
105learning (GO:0007612)2.92936507
106female mating behavior (GO:0060180)2.89783003
107calcium ion-dependent exocytosis (GO:0017156)2.89340744
108regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.88490237
109regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.88490237
110transmission of nerve impulse (GO:0019226)2.88063797
111synapse assembly (GO:0007416)2.87732087
112cullin deneddylation (GO:0010388)2.85075930
113peptidyl-cysteine modification (GO:0018198)2.82642275
114negative regulation of DNA recombination (GO:0045910)2.79117423
115DNA damage response, detection of DNA damage (GO:0042769)2.77706082
116mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.77551852
117regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.73414983
118regulation of mitotic spindle checkpoint (GO:1903504)2.73414983
119respiratory chain complex IV assembly (GO:0008535)2.72094325
120positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.69878735
121nucleobase catabolic process (GO:0046113)2.65914051
122neurofilament cytoskeleton organization (GO:0060052)2.64578260
123retinal cone cell development (GO:0046549)2.63126258
124protein deneddylation (GO:0000338)2.62026707
125negative regulation of heart rate (GO:0010459)2.62025778
126establishment of protein localization to mitochondrial membrane (GO:0090151)2.59640518
127lactate metabolic process (GO:0006089)2.53159879
128innervation (GO:0060384)2.52583435
129C4-dicarboxylate transport (GO:0015740)2.52403636
130somatic diversification of immune receptors via somatic mutation (GO:0002566)2.49444846
131somatic hypermutation of immunoglobulin genes (GO:0016446)2.49444846
132dendritic spine morphogenesis (GO:0060997)2.49416042
133regulation of coenzyme metabolic process (GO:0051196)2.48773294
134regulation of cofactor metabolic process (GO:0051193)2.48773294
135glycerophospholipid catabolic process (GO:0046475)2.47568013
136lysine metabolic process (GO:0006553)2.47098000
137lysine catabolic process (GO:0006554)2.47098000
138regulation of helicase activity (GO:0051095)2.46493072
139establishment of viral latency (GO:0019043)2.45627654
140IMP biosynthetic process (GO:0006188)2.44752249
141negative regulation of telomere maintenance (GO:0032205)2.44049796
142aspartate family amino acid catabolic process (GO:0009068)2.43988718
143cell communication by electrical coupling (GO:0010644)2.43818895
144detection of calcium ion (GO:0005513)2.42132119
145cellular potassium ion homeostasis (GO:0030007)2.39262062
146female gonad development (GO:0008585)2.38724417
147mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.36743679
148regulation of telomere maintenance via telomerase (GO:0032210)2.36736176
149negative regulation of translation, ncRNA-mediated (GO:0040033)2.36047778
150regulation of translation, ncRNA-mediated (GO:0045974)2.36047778
151negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.36047778
152establishment of mitochondrion localization (GO:0051654)2.35321723
153acidic amino acid transport (GO:0015800)2.34626213
154aldehyde catabolic process (GO:0046185)2.32209276
155cytochrome complex assembly (GO:0017004)2.30739298
156L-alpha-amino acid transmembrane transport (GO:1902475)2.30574124
157neuromuscular synaptic transmission (GO:0007274)2.29444791

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.59651464
2* GBX2_23144817_ChIP-Seq_PC3_Human4.41375143
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.33131285
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.17125466
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.00769947
6REST_21632747_ChIP-Seq_MESCs_Mouse2.91093492
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.86834598
8TAF15_26573619_Chip-Seq_HEK293_Human2.77937603
9NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.68523075
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.55294317
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.53486294
12REST_18959480_ChIP-ChIP_MESCs_Mouse2.51673443
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.48357119
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.47680597
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.47680597
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.46067220
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.45866213
18RARB_27405468_Chip-Seq_BRAIN_Mouse2.44437635
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.42369912
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.39393205
21SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.33942324
22CTBP2_25329375_ChIP-Seq_LNCAP_Human2.30362099
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.26709332
24MTF2_20144788_ChIP-Seq_MESCs_Mouse2.25615803
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.22263898
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.19710051
27CTBP1_25329375_ChIP-Seq_LNCAP_Human2.05605216
28SUZ12_27294783_Chip-Seq_ESCs_Mouse2.01142022
29DROSHA_22980978_ChIP-Seq_HELA_Human2.00413862
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.97593178
31EZH2_27294783_Chip-Seq_ESCs_Mouse1.97351389
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.95701243
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.95357793
34* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.92810521
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.92470260
36RNF2_27304074_Chip-Seq_ESCs_Mouse1.91943674
37SALL1_21062744_ChIP-ChIP_HESCs_Human1.89940733
38EST1_17652178_ChIP-ChIP_JURKAT_Human1.87956857
39SMAD4_21799915_ChIP-Seq_A2780_Human1.86665396
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.84843788
41MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.80733730
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.78642593
43* SOX2_16153702_ChIP-ChIP_HESCs_Human1.75474550
44BMI1_23680149_ChIP-Seq_NPCS_Mouse1.75371413
45IKZF1_21737484_ChIP-ChIP_HCT116_Human1.74565063
46HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.74442417
47P300_19829295_ChIP-Seq_ESCs_Human1.72792705
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.72408481
49GABP_17652178_ChIP-ChIP_JURKAT_Human1.70647739
50* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.67041987
51AR_21572438_ChIP-Seq_LNCaP_Human1.65538151
52NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.58821685
53GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58582319
54* NANOG_16153702_ChIP-ChIP_HESCs_Human1.53285002
55* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.53214699
56CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.52496528
57VDR_22108803_ChIP-Seq_LS180_Human1.48740381
58PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47277102
59POU3F2_20337985_ChIP-ChIP_501MEL_Human1.45527603
60RNF2_27304074_Chip-Seq_NSC_Mouse1.45105590
61EWS_26573619_Chip-Seq_HEK293_Human1.44609157
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42051241
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40311190
64CBX2_27304074_Chip-Seq_ESCs_Mouse1.40276248
65PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39547794
66AR_25329375_ChIP-Seq_VCAP_Human1.39454636
67SMAD3_21741376_ChIP-Seq_EPCs_Human1.38360671
68* SOX2_21211035_ChIP-Seq_LN229_Gbm1.38129442
69FUS_26573619_Chip-Seq_HEK293_Human1.36536885
70PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.36509685
71ERG_21242973_ChIP-ChIP_JURKAT_Human1.36023088
72OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35880144
73THAP11_20581084_ChIP-Seq_MESCs_Mouse1.33347294
74SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31461512
75PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.30756256
76PIAS1_25552417_ChIP-Seq_VCAP_Human1.30019089
77RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.29876747
78* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.25335239
79NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23537318
80ZNF274_21170338_ChIP-Seq_K562_Hela1.23512423
81TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.23240890
82* STAT3_23295773_ChIP-Seq_U87_Human1.22252339
83POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21188991
84SMAD_19615063_ChIP-ChIP_OVARY_Human1.19344399
85RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.18845276
86MYC_18940864_ChIP-ChIP_HL60_Human1.18618841
87EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18357549
88SOX2_18555785_ChIP-Seq_MESCs_Mouse1.16913989
89CREB1_15753290_ChIP-ChIP_HEK293T_Human1.16776222
90TCF4_23295773_ChIP-Seq_U87_Human1.16318546
91CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16018535
92ER_23166858_ChIP-Seq_MCF-7_Human1.14754598
93ETS1_20019798_ChIP-Seq_JURKAT_Human1.14748898
94IGF1R_20145208_ChIP-Seq_DFB_Human1.14044396
95RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.12779699
96IRF1_19129219_ChIP-ChIP_H3396_Human1.12217595
97P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11805141
98JUN_21703547_ChIP-Seq_K562_Human1.11649081
99DNAJC2_21179169_ChIP-ChIP_NT2_Human1.11292606
100AR_19668381_ChIP-Seq_PC3_Human1.09199205
101GATA1_26923725_Chip-Seq_HPCs_Mouse1.08819966
102UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08518008
103YY1_21170310_ChIP-Seq_MESCs_Mouse1.07580729
104MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06897561
105JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.06108441
106RBPJ_22232070_ChIP-Seq_NCS_Mouse1.05349601
107FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.04788316
108PRDM14_20953172_ChIP-Seq_ESCs_Human1.03648009
109KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.02434259
110KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.02434259
111KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.02434259
112* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.02162059
113RING1B_27294783_Chip-Seq_ESCs_Mouse1.01949945
114SOX9_26525672_Chip-Seq_HEART_Mouse1.01842887
115TBX3_20139965_ChIP-Seq_MESCs_Mouse1.01779206
116RUNX2_22187159_ChIP-Seq_PCA_Human1.01747063
117TBX3_20139965_ChIP-Seq_ESCs_Mouse1.01594763
118ARNT_22903824_ChIP-Seq_MCF-7_Human1.01507693
119MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01258803
120AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99924120
121HTT_18923047_ChIP-ChIP_STHdh_Human0.99134562
122MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98118393
123YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98081580
124* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97546229
125KLF5_20875108_ChIP-Seq_MESCs_Mouse0.95919226
126ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.94688145
127TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94366910
128SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.94162211
129PCGF2_27294783_Chip-Seq_NPCs_Mouse0.94000849
130AHR_22903824_ChIP-Seq_MCF-7_Human0.93409021
131NANOG_18555785_Chip-Seq_ESCs_Mouse0.92460875
132SMAD3_21741376_ChIP-Seq_ESCs_Human0.92381999
133PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.91878149
134CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.90826609
135NANOG_19829295_ChIP-Seq_ESCs_Human0.90616025
136SOX2_19829295_ChIP-Seq_ESCs_Human0.90616025
137MYC_18555785_ChIP-Seq_MESCs_Mouse0.88740302
138SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.88296794
139E2F4_17652178_ChIP-ChIP_JURKAT_Human0.87319145
140ELK1_19687146_ChIP-ChIP_HELA_Human0.87009742
141TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.86883801
142CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.86871236
143RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.86586775
144DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.86109368
145POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.84394337
146TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84394337
147E2F1_18555785_Chip-Seq_ESCs_Mouse0.81547024
148KDM2B_26808549_Chip-Seq_REH_Human0.80886379
149GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.79260679
150TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.78950708
151IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.78560384
152CBP_20019798_ChIP-Seq_JUKART_Human0.78560384

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.49188800
2MP0003880_abnormal_central_pattern5.02885108
3MP0003635_abnormal_synaptic_transmissio3.94842995
4MP0009046_muscle_twitch3.66547413
5MP0001968_abnormal_touch/_nociception3.50113701
6MP0004270_analgesia3.49890163
7MP0009745_abnormal_behavioral_response3.49230890
8MP0002064_seizures3.38470793
9MP0002063_abnormal_learning/memory/cond3.21729314
10MP0002736_abnormal_nociception_after3.16464912
11MP0002572_abnormal_emotion/affect_behav2.90751852
12MP0002272_abnormal_nervous_system2.82321642
13MP0002735_abnormal_chemical_nociception2.81743098
14MP0002734_abnormal_mechanical_nocicepti2.80158130
15MP0002822_catalepsy2.72853364
16MP0001486_abnormal_startle_reflex2.39260882
17MP0001501_abnormal_sleep_pattern2.31561658
18* MP0008877_abnormal_DNA_methylation2.21529060
19MP0002067_abnormal_sensory_capabilities2.20315402
20MP0001440_abnormal_grooming_behavior2.17079505
21MP0005423_abnormal_somatic_nervous2.15095641
22MP0002254_reproductive_system_inflammat2.13583215
23MP0002733_abnormal_thermal_nociception2.11612099
24MP0001970_abnormal_pain_threshold2.11402482
25MP0006276_abnormal_autonomic_nervous2.09277447
26MP0005646_abnormal_pituitary_gland2.08113623
27MP0002102_abnormal_ear_morphology2.00634224
28MP0009780_abnormal_chondrocyte_physiolo1.93396712
29MP0001529_abnormal_vocalization1.91305636
30MP0003879_abnormal_hair_cell1.90065489
31MP0003941_abnormal_skin_development1.81015204
32MP0002184_abnormal_innervation1.79755989
33MP0005386_behavior/neurological_phenoty1.77141457
34MP0004924_abnormal_behavior1.77141457
35MP0003890_abnormal_embryonic-extraembry1.74752183
36MP0001984_abnormal_olfaction1.74492497
37MP0008569_lethality_at_weaning1.74237680
38MP0002557_abnormal_social/conspecific_i1.73316353
39MP0004142_abnormal_muscle_tone1.70569444
40MP0004811_abnormal_neuron_physiology1.69669424
41MP0004858_abnormal_nervous_system1.60986136
42MP0006072_abnormal_retinal_apoptosis1.58425224
43MP0004133_heterotaxia1.57632894
44MP0000778_abnormal_nervous_system1.56789118
45* MP0003121_genomic_imprinting1.52810821
46MP0001905_abnormal_dopamine_level1.48058269
47MP0008058_abnormal_DNA_repair1.47342246
48MP0006292_abnormal_olfactory_placode1.44522327
49MP0000955_abnormal_spinal_cord1.43844654
50* MP0003787_abnormal_imprinting1.42363666
51MP0001188_hyperpigmentation1.40572762
52* MP0002066_abnormal_motor_capabilities/c1.40542122
53MP0002882_abnormal_neuron_morphology1.36353953
54MP0005645_abnormal_hypothalamus_physiol1.34422369
55MP0002909_abnormal_adrenal_gland1.32269594
56MP0002837_dystrophic_cardiac_calcinosis1.31697494
57MP0000751_myopathy1.30346825
58MP0003329_amyloid_beta_deposits1.28609789
59MP0003119_abnormal_digestive_system1.28528334
60MP0002876_abnormal_thyroid_physiology1.27792209
61MP0003011_delayed_dark_adaptation1.23926863
62MP0002090_abnormal_vision1.21097075
63MP0003646_muscle_fatigue1.18463089
64MP0003633_abnormal_nervous_system1.16257948
65MP0003718_maternal_effect1.13333753
66MP0001502_abnormal_circadian_rhythm1.12218529
67MP0008872_abnormal_physiological_respon1.10802617
68MP0003567_abnormal_fetal_cardiomyocyte1.08957922
69MP0001986_abnormal_taste_sensitivity1.08367831
70MP0002653_abnormal_ependyma_morphology1.07767140
71MP0008789_abnormal_olfactory_epithelium1.06834335
72MP0005253_abnormal_eye_physiology1.04688252
73MP0004147_increased_porphyrin_level1.03068364
74MP0003631_nervous_system_phenotype1.02960659
75MP0002152_abnormal_brain_morphology1.01070747
76MP0000013_abnormal_adipose_tissue1.00287879
77MP0002229_neurodegeneration0.99261000
78MP0003693_abnormal_embryo_hatching0.99093719
79MP0010386_abnormal_urinary_bladder0.99085746
80MP0001293_anophthalmia0.97305907
81MP0001963_abnormal_hearing_physiology0.97243081
82MP0005499_abnormal_olfactory_system0.95096189
83MP0005394_taste/olfaction_phenotype0.95096189
84MP0003136_yellow_coat_color0.92511357
85MP0004233_abnormal_muscle_weight0.91185864
86MP0004885_abnormal_endolymph0.90827385
87MP0005551_abnormal_eye_electrophysiolog0.90358991
88* MP0009672_abnormal_birth_weight0.89712215
89* MP0002069_abnormal_eating/drinking_beha0.89462117
90MP0001299_abnormal_eye_distance/0.89363711
91MP0003123_paternal_imprinting0.87304359
92* MP0003122_maternal_imprinting0.86057537
93MP0003183_abnormal_peptide_metabolism0.85955021
94MP0004085_abnormal_heartbeat0.85911235
95MP0004215_abnormal_myocardial_fiber0.85118177
96MP0008932_abnormal_embryonic_tissue0.84643449
97MP0006036_abnormal_mitochondrial_physio0.84020972
98MP0004957_abnormal_blastocyst_morpholog0.83883818
99MP0002938_white_spotting0.83580477
100MP0004043_abnormal_pH_regulation0.83183159
101MP0003283_abnormal_digestive_organ0.82847987
102MP0008874_decreased_physiological_sensi0.81618734
103MP0001664_abnormal_digestion0.81456661
104MP0003861_abnormal_nervous_system0.79911824
105MP0002752_abnormal_somatic_nervous0.79573528
106MP0000579_abnormal_nail_morphology0.78104386
107MP0004742_abnormal_vestibular_system0.77038750
108MP0004484_altered_response_of0.75556291
109MP0004145_abnormal_muscle_electrophysio0.73929191
110MP0005171_absent_coat_pigmentation0.72897415
111MP0000631_abnormal_neuroendocrine_gland0.72111161
112MP0003632_abnormal_nervous_system0.69110624
113MP0006035_abnormal_mitochondrial_morpho0.68339125
114MP0005535_abnormal_body_temperature0.68252840
115MP0008260_abnormal_autophagy0.67380751
116MP0001177_atelectasis0.67207199
117MP0002638_abnormal_pupillary_reflex0.66638380
118MP0001485_abnormal_pinna_reflex0.65201331
119MP0003634_abnormal_glial_cell0.64450644
120MP0002751_abnormal_autonomic_nervous0.64367791
121MP0004036_abnormal_muscle_relaxation0.61782539
122MP0001943_abnormal_respiration0.61574378
123MP0002332_abnormal_exercise_endurance0.57897883
124MP0000026_abnormal_inner_ear0.55490732
125* MP0010770_preweaning_lethality0.55228411
126* MP0002082_postnatal_lethality0.55228411
127* MP0010769_abnormal_survival0.53936153
128MP0003137_abnormal_impulse_conducting0.52445404
129* MP0010768_mortality/aging0.51257513
130* MP0003956_abnormal_body_size0.50868533
131MP0008004_abnormal_stomach_pH0.47254679

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.49969920
2Myokymia (HP:0002411)6.36935391
3Atonic seizures (HP:0010819)6.22275557
4Epileptic encephalopathy (HP:0200134)5.87345674
5Focal seizures (HP:0007359)5.52479723
6Febrile seizures (HP:0002373)5.51004400
7Absence seizures (HP:0002121)4.67830276
8Hyperventilation (HP:0002883)4.53615885
9Visual hallucinations (HP:0002367)4.31472574
10Dialeptic seizures (HP:0011146)4.26539119
11Progressive cerebellar ataxia (HP:0002073)4.24783415
12Generalized tonic-clonic seizures (HP:0002069)3.91817260
13Pheochromocytoma (HP:0002666)3.68993908
14Broad-based gait (HP:0002136)3.44603668
15Colon cancer (HP:0003003)3.42467928
16Neuroendocrine neoplasm (HP:0100634)3.40985771
17Gaze-evoked nystagmus (HP:0000640)3.36039680
18Impaired vibration sensation in the lower limbs (HP:0002166)3.28694872
19Cerebral hypomyelination (HP:0006808)3.00717607
20Dysdiadochokinesis (HP:0002075)2.91327900
21Abnormal mitochondria in muscle tissue (HP:0008316)2.90607802
22Action tremor (HP:0002345)2.90172501
23Amblyopia (HP:0000646)2.88861885
24Acute necrotizing encephalopathy (HP:0006965)2.88332215
25Epileptiform EEG discharges (HP:0011182)2.87365738
26Hypoglycemic seizures (HP:0002173)2.87306582
27* Abnormality of the labia minora (HP:0012880)2.86706790
28Gait imbalance (HP:0002141)2.86461967
29Poor eye contact (HP:0000817)2.85434470
30Truncal ataxia (HP:0002078)2.83608379
31Hyperglycinemia (HP:0002154)2.78525147
32Ependymoma (HP:0002888)2.77321949
33Depression (HP:0000716)2.76504775
34Ankle clonus (HP:0011448)2.75151287
35Limb dystonia (HP:0002451)2.73474005
36Septo-optic dysplasia (HP:0100842)2.70704154
37Impaired social interactions (HP:0000735)2.67950015
38Abnormal social behavior (HP:0012433)2.67950015
39Anxiety (HP:0000739)2.66593525
40Progressive inability to walk (HP:0002505)2.65003590
41Congenital primary aphakia (HP:0007707)2.60036545
42EEG with generalized epileptiform discharges (HP:0011198)2.58744473
43Dysmetric saccades (HP:0000641)2.58334055
44Urinary bladder sphincter dysfunction (HP:0002839)2.58186256
45Progressive macrocephaly (HP:0004481)2.57151661
46Abnormality of the lower motor neuron (HP:0002366)2.55971914
47Hyperinsulinemic hypoglycemia (HP:0000825)2.55339555
48Methylmalonic acidemia (HP:0002912)2.51556876
49Medial flaring of the eyebrow (HP:0010747)2.51357021
50Dysmetria (HP:0001310)2.48539494
51Resting tremor (HP:0002322)2.48464721
52* Abnormal eating behavior (HP:0100738)2.47130685
53Nephrogenic diabetes insipidus (HP:0009806)2.46580516
54Hypsarrhythmia (HP:0002521)2.46149738
55Inability to walk (HP:0002540)2.44751759
56Hypoglycemic coma (HP:0001325)2.44167363
57Scanning speech (HP:0002168)2.43995568
58Fetal akinesia sequence (HP:0001989)2.43562974
59Drooling (HP:0002307)2.43270664
60Excessive salivation (HP:0003781)2.43270664
61Hepatoblastoma (HP:0002884)2.36730216
62Abnormality of glycolysis (HP:0004366)2.36529007
63Increased serum pyruvate (HP:0003542)2.36529007
64Abnormality of serine family amino acid metabolism (HP:0010894)2.36445828
65Abnormality of glycine metabolism (HP:0010895)2.36445828
66Impaired vibratory sensation (HP:0002495)2.33756517
67Diplopia (HP:0000651)2.31451389
68Abnormality of binocular vision (HP:0011514)2.31451389
69Urinary urgency (HP:0000012)2.31435170
70Protruding tongue (HP:0010808)2.31013539
71Insidious onset (HP:0003587)2.30893050
72Termporal pattern (HP:0011008)2.30893050
73Impaired smooth pursuit (HP:0007772)2.30586377
74Bradykinesia (HP:0002067)2.30307648
75Spastic gait (HP:0002064)2.24442632
76Cortical dysplasia (HP:0002539)2.23741395
77Mitochondrial inheritance (HP:0001427)2.22549869
78Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.22547537
79Neoplasm of the peripheral nervous system (HP:0100007)2.22507867
80Status epilepticus (HP:0002133)2.21540379
81Hyperglycinuria (HP:0003108)2.21472558
82Focal dystonia (HP:0004373)2.21464303
83Postural instability (HP:0002172)2.20707745
84Agnosia (HP:0010524)2.19977647
85Torticollis (HP:0000473)2.17066387
86Intestinal atresia (HP:0011100)2.16428523
87Optic nerve hypoplasia (HP:0000609)2.16093125
88Supranuclear gaze palsy (HP:0000605)2.15967493
89CNS hypomyelination (HP:0003429)2.15711788
90Acute encephalopathy (HP:0006846)2.14116039
91Abnormality of serum amino acid levels (HP:0003112)2.13340512
92Methylmalonic aciduria (HP:0012120)2.11821125
93Sensory axonal neuropathy (HP:0003390)2.11353792
94Absent speech (HP:0001344)2.10108244
95Blue irides (HP:0000635)2.08651432
96Abnormality of the corticospinal tract (HP:0002492)2.08599766
97Hyperthyroidism (HP:0000836)2.08246674
98Genetic anticipation (HP:0003743)2.08059978
99Abnormal gallbladder physiology (HP:0012438)2.03904767
100Cholecystitis (HP:0001082)2.03904767
101Hepatocellular necrosis (HP:0001404)2.03205340
102Incomplete penetrance (HP:0003829)2.02604947
103Genital tract atresia (HP:0001827)2.02525645
104Hypomagnesemia (HP:0002917)2.02042879
105Increased CSF lactate (HP:0002490)2.00592070
106Abnormality of ocular smooth pursuit (HP:0000617)1.99814551
107* Specific learning disability (HP:0001328)1.99684811
108Pancreatic islet-cell hyperplasia (HP:0004510)1.99593781
109Delusions (HP:0000746)1.98869830
110Vaginal atresia (HP:0000148)1.98656604
111Gait ataxia (HP:0002066)1.96196547
112Poor coordination (HP:0002370)1.95473256
113Intention tremor (HP:0002080)1.95171240
114Craniofacial dystonia (HP:0012179)1.94853425
115Neoplasm of the adrenal gland (HP:0100631)1.94209343
116Generalized myoclonic seizures (HP:0002123)1.92477814
117Leukodystrophy (HP:0002415)1.91930948
118Hemiparesis (HP:0001269)1.89227435
119Abolished electroretinogram (ERG) (HP:0000550)1.87382937
120Mutism (HP:0002300)1.87311546
121Increased hepatocellular lipid droplets (HP:0006565)1.87057978
122Exercise-induced muscle cramps (HP:0003710)1.86966145
123Cerebral edema (HP:0002181)1.84405874
124Muscular hypotonia of the trunk (HP:0008936)1.84015789
125Astrocytoma (HP:0009592)1.83986229
126Abnormality of the astrocytes (HP:0100707)1.83986229
127Lower limb muscle weakness (HP:0007340)1.81158827
128Broad foot (HP:0001769)1.80559602
129Hemiplegia (HP:0002301)1.79956914
130Akinesia (HP:0002304)1.79148730
131Absent septum pellucidum (HP:0001331)1.77843065
132Abnormal lung lobation (HP:0002101)1.77324724
133Lissencephaly (HP:0001339)1.76182389
134Restlessness (HP:0000711)1.75433053
135Stenosis of the external auditory canal (HP:0000402)1.75308087
136Hypothermia (HP:0002045)1.75248747
137Abnormality of endocrine pancreas physiology (HP:0012093)1.75184339
138Abnormality of the pancreatic islet cells (HP:0006476)1.75184339
139Stereotypic behavior (HP:0000733)1.74566190
140Amyotrophic lateral sclerosis (HP:0007354)1.74479243
141Postural tremor (HP:0002174)1.73749169
142Aqueductal stenosis (HP:0002410)1.73410730
143Decreased activity of mitochondrial respiratory chain (HP:0008972)1.72934767
144Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.72934767
145Optic disc pallor (HP:0000543)1.72917573
146Hepatic necrosis (HP:0002605)1.72786885
147Prominent metopic ridge (HP:0005487)1.71489218
148Degeneration of the lateral corticospinal tracts (HP:0002314)1.70598643
149Spastic tetraplegia (HP:0002510)1.69520644
150Spastic diplegia (HP:0001264)1.67489876
151Glioma (HP:0009733)1.66076557

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.28146429
2NTRK33.80194741
3MAP3K123.59680696
4MAP3K43.30627401
5MAP2K73.19000013
6EPHA42.89110727
7CDK192.81304880
8TRIM282.72667495
9MAP3K92.54400119
10DAPK22.49826709
11MINK12.38480643
12AKT32.21220865
13PLK22.17230949
14DAPK12.16309854
15DYRK22.11865760
16MARK12.11427389
17MAP2K42.06796367
18TSSK62.01851742
19BUB11.98760756
20MAP4K21.90739175
21MKNK21.87811320
22PRPF4B1.87778168
23CCNB11.78661360
24GRK51.62334507
25ZAK1.62052401
26OXSR11.57594735
27NTRK21.56662810
28MKNK11.50310751
29CSNK1G11.48683570
30PAK61.48237315
31SIK31.45320521
32TTK1.44815745
33ARAF1.44329338
34NUAK11.42899400
35CSNK1G31.37362415
36PRKCG1.35208701
37PDK41.34434299
38PDK31.34434299
39MAPK131.33943460
40CDC71.33239013
41FGFR21.31665411
42SGK4941.27463619
43SGK2231.27463619
44SRPK11.27248777
45VRK21.26752263
46MST41.24771898
47SGK21.24688210
48CDK51.24150313
49NEK11.22635191
50NME11.20876347
51CAMKK21.20084703
52STK161.19729449
53KSR11.17233902
54CAMKK11.13178287
55ALK1.09154681
56KSR21.07814954
57BRAF1.07300042
58BMPR1B1.02239075
59CAMK2A0.99805871
60CSNK1A1L0.98980399
61NTRK10.96456812
62CDK180.95137074
63GRK10.95000784
64FRK0.94556004
65CAMK2B0.90652199
66UHMK10.89426881
67VRK10.87932907
68RIPK40.87746188
69CDK140.87598807
70CDK150.86355956
71PLK10.85859307
72SGK30.82730317
73PASK0.79915884
74BCR0.79622583
75ACVR1B0.79176813
76TNIK0.77819949
77TIE10.77394296
78PDK20.76432875
79PRKD30.75566448
80STK38L0.75547566
81PNCK0.75210753
82CDK11A0.73759030
83PHKG20.72955157
84PHKG10.72955157
85STK380.70968800
86PRKCE0.70472500
87TAF10.69773252
88BCKDK0.69648235
89DAPK30.67234913
90FES0.66481018
91PLK40.60349674
92CAMK10.59776042
93PTK2B0.59387808
94NLK0.58534420
95WNK30.58246149
96PINK10.57607290
97LMTK20.57399395
98CAMK2G0.56808869
99CSNK1E0.56680292
100DYRK30.56333659
101LIMK10.55862183
102MYLK0.55370625
103PBK0.54749957
104TNK20.54298816
105PRKCH0.53907190
106LATS20.53196087
107ADRBK10.52672649
108SGK10.51851643
109ADRBK20.51537753
110FER0.50878474
111GRK70.50671890
112BMPR20.49986063
113STK110.49927349
114MAP3K20.49018810
115EIF2AK30.48910481
116DYRK1A0.47933493
117CAMK2D0.47733257
118ERBB30.46920220
119CSNK1A10.46468777
120PRKDC0.45292617
121FGFR10.44652515
122CSNK1G20.44450084
123TESK10.44246038
124MAP2K10.43719170
125PDK10.43017643
126CAMK40.43004803
127SIK20.42122313
128PDPK10.39855198
129CDK80.38562414
130INSRR0.38143484
131CSNK1D0.36886274
132ATM0.36140328
133RPS6KA20.35229819
134RPS6KA30.35006040
135ERBB40.34797538
136PLK30.34617581
137TYRO30.34240253
138BRSK10.33525531
139PRKACA0.33425038
140ROCK20.31956371
141TAOK10.31660245
142PAK30.31429921
143RAF10.31277119
144RET0.30206215

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047214.58962782
2Nicotine addiction_Homo sapiens_hsa050334.08237000
3Collecting duct acid secretion_Homo sapiens_hsa049663.50600095
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.71625327
5GABAergic synapse_Homo sapiens_hsa047272.71051656
6Olfactory transduction_Homo sapiens_hsa047402.62734477
7Morphine addiction_Homo sapiens_hsa050322.47643443
8Circadian entrainment_Homo sapiens_hsa047132.47558253
9Long-term potentiation_Homo sapiens_hsa047202.31380503
10Amphetamine addiction_Homo sapiens_hsa050312.26716139
11Glutamatergic synapse_Homo sapiens_hsa047242.21601763
12Vibrio cholerae infection_Homo sapiens_hsa051102.18083683
13Proteasome_Homo sapiens_hsa030502.17793691
14Dopaminergic synapse_Homo sapiens_hsa047282.05985833
15Oxidative phosphorylation_Homo sapiens_hsa001901.99077907
16Taste transduction_Homo sapiens_hsa047421.90499835
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.90073727
18Protein export_Homo sapiens_hsa030601.86712724
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.85603982
20Insulin secretion_Homo sapiens_hsa049111.83525851
21Salivary secretion_Homo sapiens_hsa049701.82290798
22Fatty acid elongation_Homo sapiens_hsa000621.77673561
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.69140391
24Propanoate metabolism_Homo sapiens_hsa006401.69120906
25Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.63867689
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.60926015
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.59468952
28Long-term depression_Homo sapiens_hsa047301.59359131
29Serotonergic synapse_Homo sapiens_hsa047261.58752517
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.56926104
31Cholinergic synapse_Homo sapiens_hsa047251.54639659
32Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.54386950
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.52117377
34Mismatch repair_Homo sapiens_hsa034301.51860162
35Steroid biosynthesis_Homo sapiens_hsa001001.49138102
36Gastric acid secretion_Homo sapiens_hsa049711.48371069
37RNA polymerase_Homo sapiens_hsa030201.46047867
38Calcium signaling pathway_Homo sapiens_hsa040201.43943576
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.40261216
40Renin secretion_Homo sapiens_hsa049241.40129767
41Parkinsons disease_Homo sapiens_hsa050121.38933259
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.37396696
43Aldosterone synthesis and secretion_Homo sapiens_hsa049251.35084852
44Cocaine addiction_Homo sapiens_hsa050301.33548084
45Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.32464279
46Non-homologous end-joining_Homo sapiens_hsa034501.29010878
47Oxytocin signaling pathway_Homo sapiens_hsa049211.28352672
48Selenocompound metabolism_Homo sapiens_hsa004501.24165680
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.23707879
50Alzheimers disease_Homo sapiens_hsa050101.19794238
51Cardiac muscle contraction_Homo sapiens_hsa042601.15896596
52Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.14827932
53Gap junction_Homo sapiens_hsa045401.12222511
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.06343316
55RNA degradation_Homo sapiens_hsa030181.03752315
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02123184
57Arginine and proline metabolism_Homo sapiens_hsa003301.00710942
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.00560954
59GnRH signaling pathway_Homo sapiens_hsa049120.97874760
60Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.97769596
61Rheumatoid arthritis_Homo sapiens_hsa053230.96180586
62Phototransduction_Homo sapiens_hsa047440.95374354
63cAMP signaling pathway_Homo sapiens_hsa040240.94942065
64Huntingtons disease_Homo sapiens_hsa050160.94354649
65beta-Alanine metabolism_Homo sapiens_hsa004100.93944168
66Basal transcription factors_Homo sapiens_hsa030220.90303530
67Phosphatidylinositol signaling system_Homo sapiens_hsa040700.88491382
68Pyruvate metabolism_Homo sapiens_hsa006200.86549474
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.86450105
70Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86257402
71ErbB signaling pathway_Homo sapiens_hsa040120.81889863
72RNA transport_Homo sapiens_hsa030130.81851789
73DNA replication_Homo sapiens_hsa030300.78074726
74Type II diabetes mellitus_Homo sapiens_hsa049300.77999527
75Oocyte meiosis_Homo sapiens_hsa041140.77983069
76Axon guidance_Homo sapiens_hsa043600.77234290
77Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.76359231
78Phagosome_Homo sapiens_hsa041450.75538802
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.75397410
80Type I diabetes mellitus_Homo sapiens_hsa049400.75087105
81Estrogen signaling pathway_Homo sapiens_hsa049150.74165926
82Maturity onset diabetes of the young_Homo sapiens_hsa049500.74095382
83Base excision repair_Homo sapiens_hsa034100.74003846
84Purine metabolism_Homo sapiens_hsa002300.73038073
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.72564012
86Fatty acid metabolism_Homo sapiens_hsa012120.72277275
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.72191708
88One carbon pool by folate_Homo sapiens_hsa006700.70211183
89Melanogenesis_Homo sapiens_hsa049160.69803327
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.69358360
91Glioma_Homo sapiens_hsa052140.67513006
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65709625
93Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.63369571
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62238228
95Tight junction_Homo sapiens_hsa045300.60513058
96Peroxisome_Homo sapiens_hsa041460.59381754
97Metabolic pathways_Homo sapiens_hsa011000.57089818
98Spliceosome_Homo sapiens_hsa030400.56128574
99Tryptophan metabolism_Homo sapiens_hsa003800.55808219
100MAPK signaling pathway_Homo sapiens_hsa040100.54227854
101Arginine biosynthesis_Homo sapiens_hsa002200.53925508
102Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53075227
103Ether lipid metabolism_Homo sapiens_hsa005650.52390193
104Fanconi anemia pathway_Homo sapiens_hsa034600.52258685
105Homologous recombination_Homo sapiens_hsa034400.51793373
106Dilated cardiomyopathy_Homo sapiens_hsa054140.49992558
107Glucagon signaling pathway_Homo sapiens_hsa049220.49716086
108Wnt signaling pathway_Homo sapiens_hsa043100.48816380
109Folate biosynthesis_Homo sapiens_hsa007900.48812200
110Glutathione metabolism_Homo sapiens_hsa004800.47984604
111Pancreatic secretion_Homo sapiens_hsa049720.46866676
112mRNA surveillance pathway_Homo sapiens_hsa030150.46600031
113Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44083412
114Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43923649
115Alcoholism_Homo sapiens_hsa050340.43904144
116Hippo signaling pathway_Homo sapiens_hsa043900.43705354
117Thyroid hormone synthesis_Homo sapiens_hsa049180.43105911
118Ras signaling pathway_Homo sapiens_hsa040140.42632670
119Nitrogen metabolism_Homo sapiens_hsa009100.40984391
120Inositol phosphate metabolism_Homo sapiens_hsa005620.37827462
121Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.37724924
122Regulation of autophagy_Homo sapiens_hsa041400.37608314
123Butanoate metabolism_Homo sapiens_hsa006500.37034174
124Circadian rhythm_Homo sapiens_hsa047100.36319803
125Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.34856909
126Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34522371
127Fructose and mannose metabolism_Homo sapiens_hsa000510.32965015
128Vitamin B6 metabolism_Homo sapiens_hsa007500.32935771
129Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.31771500
130Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30794088
131Carbon metabolism_Homo sapiens_hsa012000.30066928
132Cysteine and methionine metabolism_Homo sapiens_hsa002700.29939225
133Melanoma_Homo sapiens_hsa052180.29150025
134Neurotrophin signaling pathway_Homo sapiens_hsa047220.28857087
135Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.28494786
136Rap1 signaling pathway_Homo sapiens_hsa040150.28304537
137Phospholipase D signaling pathway_Homo sapiens_hsa040720.28198916
138Insulin signaling pathway_Homo sapiens_hsa049100.28179304
139Endocytosis_Homo sapiens_hsa041440.27400175
140Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.26695842
141Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.24843975
142Choline metabolism in cancer_Homo sapiens_hsa052310.24177860
143Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.23539367
144Biosynthesis of amino acids_Homo sapiens_hsa012300.23357527
145Dorso-ventral axis formation_Homo sapiens_hsa043200.19685317
146Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.18504702
147Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.18481837

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