SNTA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Syntrophins are cytoplasmic peripheral membrane scaffold proteins that are components of the dystrophin-associated protein complex. This gene is a member of the syntrophin gene family and encodes the most common syntrophin isoform found in cardiac tissues. The N-terminal PDZ domain of this syntrophin protein interacts with the C-terminus of the pore-forming alpha subunit (SCN5A) of the cardiac sodium channel Nav1.5. This protein also associates cardiac sodium channels with the nitric oxide synthase-PMCA4b (plasma membrane Ca-ATPase subtype 4b) complex in cardiomyocytes. This gene is a susceptibility locus for Long-QT syndrome (LQT) - an inherited disorder associated with sudden cardiac death from arrhythmia - and sudden infant death syndrome (SIDS). This protein also associates with dystrophin and dystrophin-related proteins at the neuromuscular junction and alters intracellular calcium ion levels in muscle tissue. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1muscle filament sliding (GO:0030049)6.51834623
2actin-myosin filament sliding (GO:0033275)6.51834623
3regulation of skeletal muscle contraction (GO:0014819)5.96240777
4sarcomere organization (GO:0045214)5.80412854
5plasma membrane repair (GO:0001778)5.42386852
6actin-mediated cell contraction (GO:0070252)5.38013857
7negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.34426210
8myofibril assembly (GO:0030239)5.04448999
9cardiac myofibril assembly (GO:0055003)4.96542430
10carnitine shuttle (GO:0006853)4.93924538
11positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.88675263
12negative regulation of potassium ion transmembrane transport (GO:1901380)4.81000454
13tricarboxylic acid cycle (GO:0006099)4.70188163
14sarcoplasmic reticulum calcium ion transport (GO:0070296)4.69655077
15fatty acid transmembrane transport (GO:1902001)4.50155042
16regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.44193524
17membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.42058725
18cardiac muscle contraction (GO:0060048)4.39787868
19striated muscle contraction (GO:0006941)4.28096937
20skeletal muscle contraction (GO:0003009)4.12953607
21actin filament-based movement (GO:0030048)4.07760269
22regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.01499500
23regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.95119495
24lysine metabolic process (GO:0006553)3.93261490
25lysine catabolic process (GO:0006554)3.93261490
26actomyosin structure organization (GO:0031032)3.90530238
272-oxoglutarate metabolic process (GO:0006103)3.89459140
28regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.89302164
29glycogen catabolic process (GO:0005980)3.82508514
30* regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.80939243
31carnitine transmembrane transport (GO:1902603)3.79965041
32cardiac muscle cell development (GO:0055013)3.77543582
33heart process (GO:0003015)3.76321840
34heart contraction (GO:0060047)3.76321840
35creatine metabolic process (GO:0006600)3.68907698
36response to inactivity (GO:0014854)3.68856867
37amino-acid betaine transport (GO:0015838)3.66717554
38carnitine transport (GO:0015879)3.66717554
39regulation of acyl-CoA biosynthetic process (GO:0050812)3.66014817
40regulation of actin filament-based movement (GO:1903115)3.65896043
41aspartate family amino acid catabolic process (GO:0009068)3.65624083
42skeletal muscle fiber development (GO:0048741)3.64808171
43cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.61364223
44glucan catabolic process (GO:0009251)3.59574094
45regulation of calcium ion transmembrane transporter activity (GO:1901019)3.59147387
46regulation of calcium ion transmembrane transport (GO:1903169)3.59147387
47cardiac cell development (GO:0055006)3.52108070
48regulation of cardiac muscle cell contraction (GO:0086004)3.51024396
49regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.48118118
50response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.46621987
51NADH metabolic process (GO:0006734)3.46532279
52regulation of sequestering of triglyceride (GO:0010889)3.45662936
53regulation of coenzyme metabolic process (GO:0051196)3.39143783
54regulation of cofactor metabolic process (GO:0051193)3.39143783
55regulation of cell communication by electrical coupling (GO:0010649)3.37064551
56synaptic vesicle docking involved in exocytosis (GO:0016081)3.36639066
57cellular polysaccharide catabolic process (GO:0044247)3.33185393
58sodium ion export (GO:0071436)3.32547537
59myotube cell development (GO:0014904)3.32264278
60cell communication by electrical coupling (GO:0010644)3.31153100
61cardiac muscle hypertrophy (GO:0003300)3.30765671
62positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.30366520
63regulation of fatty acid oxidation (GO:0046320)3.30346544
64fatty acid beta-oxidation (GO:0006635)3.29974198
65skeletal muscle adaptation (GO:0043501)3.28479701
66* muscle contraction (GO:0006936)3.26981913
67striated muscle hypertrophy (GO:0014897)3.24260916
68adult heart development (GO:0007512)3.22110977
69detection of calcium ion (GO:0005513)3.20555369
70regulation of striated muscle contraction (GO:0006942)3.19664832
71relaxation of cardiac muscle (GO:0055119)3.18068140
72muscle fiber development (GO:0048747)3.17688860
73regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.17557099
74muscle cell cellular homeostasis (GO:0046716)3.17340053
75muscle cell fate commitment (GO:0042693)3.17115212
76cellular potassium ion homeostasis (GO:0030007)3.17097928
77heart trabecula formation (GO:0060347)3.16826330
78relaxation of muscle (GO:0090075)3.14534223
79acetyl-CoA metabolic process (GO:0006084)3.12979152
80cardiac muscle tissue morphogenesis (GO:0055008)3.11089826
81polysaccharide catabolic process (GO:0000272)3.10590811
82regulation of ATPase activity (GO:0043462)3.08864148
83regulation of ATP catabolic process (GO:1903289)3.08864148
84regulation of relaxation of muscle (GO:1901077)3.06745530
85cell communication involved in cardiac conduction (GO:0086065)3.06391199
86positive regulation of fatty acid oxidation (GO:0046321)3.06244863
87* ventricular cardiac muscle cell action potential (GO:0086005)3.04954390
88negative regulation of calcium ion transmembrane transport (GO:1903170)3.04494881
89negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.04494881
90gluconeogenesis (GO:0006094)3.02808230
91positive regulation of fatty acid beta-oxidation (GO:0032000)3.02132882
92tricarboxylic acid metabolic process (GO:0072350)3.01803358
93glycogen biosynthetic process (GO:0005978)3.01098551
94glucan biosynthetic process (GO:0009250)3.01098551
95cellular response to epinephrine stimulus (GO:0071872)2.99871350
96* regulation of membrane repolarization (GO:0060306)2.98958824
97cardiac chamber formation (GO:0003207)2.98858888
98positive regulation of cation channel activity (GO:2001259)2.98127437
99response to epinephrine (GO:0071871)2.97921166
100activation of protein kinase A activity (GO:0034199)2.97414527
101* regulation of heart contraction (GO:0008016)2.96608444
102* muscle system process (GO:0003012)2.95390856
103quaternary ammonium group transport (GO:0015697)2.94180240
104succinate metabolic process (GO:0006105)2.93026728
105fatty acid homeostasis (GO:0055089)2.91766269
106short-chain fatty acid metabolic process (GO:0046459)2.91746653
107muscle tissue morphogenesis (GO:0060415)2.91452963
108regulation of skeletal muscle cell differentiation (GO:2001014)2.89268876
109response to muscle activity (GO:0014850)2.88584028
110oxaloacetate metabolic process (GO:0006107)2.88194438
111fatty acid catabolic process (GO:0009062)2.86044754
112regulation of cardiac muscle contraction (GO:0055117)2.85330865
113lipid oxidation (GO:0034440)2.84762731
114regulation of muscle contraction (GO:0006937)2.84723275
115pyrimidine ribonucleoside catabolic process (GO:0046133)2.83786923
116fatty acid oxidation (GO:0019395)2.83313537
117striated muscle adaptation (GO:0014888)2.83155150
118biotin metabolic process (GO:0006768)2.82666779
119regulation of the force of heart contraction (GO:0002026)2.82653914
120regulation of muscle system process (GO:0090257)2.82590229
121muscle hypertrophy (GO:0014896)2.81558729
122* regulation of heart rate (GO:0002027)2.80915999
123cardiac ventricle formation (GO:0003211)2.79670624
124dicarboxylic acid biosynthetic process (GO:0043650)2.79483348
125muscle adaptation (GO:0043500)2.79471731
126positive regulation of myotube differentiation (GO:0010831)2.78852799
127glycogen metabolic process (GO:0005977)2.75330225
128positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.74454010
129ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.72561394
130negative regulation of potassium ion transport (GO:0043267)2.72080645
131bundle of His cell to Purkinje myocyte communication (GO:0086069)2.71312947
132glucan metabolic process (GO:0044042)2.70281889
133cellular glucan metabolic process (GO:0006073)2.70281889
134cardiac muscle hypertrophy in response to stress (GO:0014898)2.69986039
135muscle hypertrophy in response to stress (GO:0003299)2.69986039
136cardiac muscle adaptation (GO:0014887)2.69986039
137negative regulation of protein localization to cell surface (GO:2000009)2.68741388
138regulation of sulfur metabolic process (GO:0042762)2.67799539
139striated muscle cell development (GO:0055002)2.65928553

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.71618542
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.44676911
3TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.14333425
4RXR_22158963_ChIP-Seq_LIVER_Mouse2.98737037
5* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.93221003
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.92169010
7PPARA_22158963_ChIP-Seq_LIVER_Mouse2.77281518
8LXR_22158963_ChIP-Seq_LIVER_Mouse2.63294438
9EP300_21415370_ChIP-Seq_HL-1_Mouse2.35390193
10TBX20_22328084_ChIP-Seq_HEART_Mouse2.33493963
11TBX20_22080862_ChIP-Seq_HEART_Mouse2.33493963
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.30851263
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.18014012
14FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.17407211
15* CLOCK_20551151_ChIP-Seq_293T_Human2.17044274
16ZNF263_19887448_ChIP-Seq_K562_Human2.10120541
17ESR2_21235772_ChIP-Seq_MCF-7_Human1.98278817
18ESR1_20079471_ChIP-ChIP_T-47D_Human1.89096535
19EZH2_27304074_Chip-Seq_ESCs_Mouse1.78913238
20TRIM28_21343339_ChIP-Seq_HEK293_Human1.77836825
21PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.65193826
22JARID2_20064375_ChIP-Seq_MESCs_Mouse1.58463158
23RNF2_27304074_Chip-Seq_ESCs_Mouse1.58070501
24CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.57525739
25SUZ12_27294783_Chip-Seq_ESCs_Mouse1.57300750
26TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.54174748
27LXR_22292898_ChIP-Seq_THP-1_Human1.54032210
28NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.47043087
29SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.41814147
30TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.40764516
31DROSHA_22980978_ChIP-Seq_HELA_Human1.39405051
32CDX2_19796622_ChIP-Seq_MESCs_Mouse1.39351897
33ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.38255674
34TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37868562
35SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.36324053
36ZFP281_18757296_ChIP-ChIP_E14_Mouse1.35532788
37MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.35410256
38SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.34225342
39TET1_21490601_ChIP-Seq_MESCs_Mouse1.32855819
40EED_16625203_ChIP-ChIP_MESCs_Mouse1.32776341
41BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.30721617
42EZH2_18974828_ChIP-Seq_MESCs_Mouse1.28488039
43RNF2_18974828_ChIP-Seq_MESCs_Mouse1.28488039
44CTCF_27219007_Chip-Seq_Bcells_Human1.27879045
45EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.23667385
46SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.23277748
47* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.22940203
48NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.22825475
49ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.22515963
50ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.22485015
51MTF2_20144788_ChIP-Seq_MESCs_Mouse1.21870072
52RACK7_27058665_Chip-Seq_MCF-7_Human1.21375109
53RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21225859
54DNAJC2_21179169_ChIP-ChIP_NT2_Human1.20120184
55* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.19661635
56TET1_21451524_ChIP-Seq_MESCs_Mouse1.19012992
57ESR1_21235772_ChIP-Seq_MCF-7_Human1.17001189
58MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.16685268
59PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15907047
60KDM2B_26808549_Chip-Seq_K562_Human1.15831785
61WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.15353982
62EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.15047455
63CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.14881632
64SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.13734937
65ERG_21242973_ChIP-ChIP_JURKAT_Human1.12240441
66STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.11763411
67* FOXA2_19822575_ChIP-Seq_HepG2_Human1.09907811
68CTCF_27219007_Chip-Seq_ERYTHROID_Human1.09496119
69* REST_18959480_ChIP-ChIP_MESCs_Mouse1.07524492
70* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07336258
71EZH2_22144423_ChIP-Seq_EOC_Human1.07254666
72* TP53_23651856_ChIP-Seq_MEFs_Mouse1.06329489
73PPAR_26484153_Chip-Seq_NCI-H1993_Human1.05518110
74* TP63_22573176_ChIP-Seq_HFKS_Human1.03975697
75ESR1_15608294_ChIP-ChIP_MCF-7_Human1.03055616
76MYC_27129775_Chip-Seq_CORNEA_Mouse1.02542946
77SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.02345615
78RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02158033
79TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01836669
80PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.00698652
81RARB_27405468_Chip-Seq_BRAIN_Mouse1.00557459
82SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.00293739
83EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00115462
84SA1_27219007_Chip-Seq_ERYTHROID_Human1.00095586
85RING1B_27294783_Chip-Seq_ESCs_Mouse0.99445949
86PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.99402503
87HIF1A_21447827_ChIP-Seq_MCF-7_Human0.99150706
88* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.98840693
89P300_27058665_Chip-Seq_ZR-75-30cells_Human0.98724544
90SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.98525351
91UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.98354791
92* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.96534606
93BP1_19119308_ChIP-ChIP_Hs578T_Human0.95659526
94NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.95505801
95CREB1_26743006_Chip-Seq_LNCaP_Human0.95409130
96NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.95131268
97SMC4_20622854_ChIP-Seq_HELA_Human0.94880935
98EZH2_27294783_Chip-Seq_ESCs_Mouse0.94660671
99TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.94252742
100OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.93465452
101ZFP281_27345836_Chip-Seq_ESCs_Mouse0.93386252
102TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.93253755
103ELK3_25401928_ChIP-Seq_HUVEC_Human0.92250370
104PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.91816459
105SRY_22984422_ChIP-ChIP_TESTIS_Rat0.91698419
106TP53_20018659_ChIP-ChIP_R1E_Mouse0.89820923
107WT1_25993318_ChIP-Seq_PODOCYTE_Human0.89192796
108* KDM2B_26808549_Chip-Seq_DND41_Human0.89084820
109P68_20966046_ChIP-Seq_HELA_Human0.88896071
110SMC1_22415368_ChIP-Seq_MEFs_Mouse0.88191977
111SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.86885090
112JARID2_20075857_ChIP-Seq_MESCs_Mouse0.86430703
113SOX9_24532713_ChIP-Seq_HFSC_Mouse0.85680228
114FOXO3_23340844_ChIP-Seq_DLD1_Human0.85560736
115* ATF3_27146783_Chip-Seq_COLON_Human0.85487983
116CJUN_26792858_Chip-Seq_BT549_Human0.83130915
117KLF4_19829295_ChIP-Seq_ESCs_Human0.82948660
118SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82065731
119RUNX1_27514584_Chip-Seq_MCF-7_Human0.79933217
120FOXH1_21741376_ChIP-Seq_ESCs_Human0.78326895
121KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.78146300
122SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.77819696
123NRF2_20460467_ChIP-Seq_MEFs_Mouse0.77724877
124NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.77724877
125SA1_27219007_Chip-Seq_Bcells_Human0.77230571
126AR_21572438_ChIP-Seq_LNCaP_Human0.76849865
127* GATA4_21415370_ChIP-Seq_HL-1_Mouse0.76779698
128SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.76665938

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.14483098
2MP0000751_myopathy4.83419875
3MP0003646_muscle_fatigue4.75779565
4MP0000749_muscle_degeneration4.14353148
5MP0004084_abnormal_cardiac_muscle3.61943232
6MP0004036_abnormal_muscle_relaxation3.52741982
7MP0004145_abnormal_muscle_electrophysio3.46744725
8MP0004215_abnormal_myocardial_fiber3.06712163
9MP0005330_cardiomyopathy2.93703540
10MP0004130_abnormal_muscle_cell2.90590940
11MP0004087_abnormal_muscle_fiber2.86349105
12MP0000750_abnormal_muscle_regeneration2.77254537
13MP0000747_muscle_weakness2.74225523
14MP0002269_muscular_atrophy2.62778070
15MP0005620_abnormal_muscle_contractility2.55001765
16MP0002106_abnormal_muscle_physiology2.54549933
17MP0000759_abnormal_skeletal_muscle2.26923529
18MP0002972_abnormal_cardiac_muscle2.21222531
19MP0005451_abnormal_body_composition2.20840133
20MP0005369_muscle_phenotype2.14061888
21MP0005670_abnormal_white_adipose2.09285270
22MP0003705_abnormal_hypodermis_morpholog2.04740687
23MP0003137_abnormal_impulse_conducting1.95923511
24MP0005666_abnormal_adipose_tissue1.94107754
25MP0004233_abnormal_muscle_weight1.90944638
26MP0008438_abnormal_cutaneous_collagen1.82924682
27MP0008775_abnormal_heart_ventricle1.77300506
28MP0010630_abnormal_cardiac_muscle1.76796793
29MP0005385_cardiovascular_system_phenoty1.76375615
30MP0001544_abnormal_cardiovascular_syste1.76375615
31MP0004484_altered_response_of1.70079427
32MP0006138_congestive_heart_failure1.66532556
33MP0005360_urolithiasis1.65354021
34MP0004185_abnormal_adipocyte_glucose1.61110093
35MP0003950_abnormal_plasma_membrane1.58320708
36MP0002332_abnormal_exercise_endurance1.57907604
37MP0006036_abnormal_mitochondrial_physio1.52229002
38MP0003806_abnormal_nucleotide_metabolis1.49920410
39MP0003279_aneurysm1.46199571
40MP0009840_abnormal_foam_cell1.42255784
41MP0002139_abnormal_hepatobiliary_system1.40485449
42MP0005375_adipose_tissue_phenotype1.35734845
43MP0002108_abnormal_muscle_morphology1.35659996
44MP0005423_abnormal_somatic_nervous1.32559030
45MP0003879_abnormal_hair_cell1.30436180
46MP0004085_abnormal_heartbeat1.28431349
47MP0000013_abnormal_adipose_tissue1.26747735
48MP0005332_abnormal_amino_acid1.21361412
49MP0002971_abnormal_brown_adipose1.21040190
50MP0005275_abnormal_skin_tensile1.20236041
51MP0008569_lethality_at_weaning1.19744429
52MP0005085_abnormal_gallbladder_physiolo1.19679767
53MP0002127_abnormal_cardiovascular_syste1.18429277
54MP0001661_extended_life_span1.09056207
55MP0003221_abnormal_cardiomyocyte_apopto1.09011553
56* MP0003635_abnormal_synaptic_transmissio1.07575352
57MP0000733_abnormal_muscle_development1.05715993
58MP0009384_cardiac_valve_regurgitation1.05221995
59MP0005365_abnormal_bile_salt1.04158411
60MP0003828_pulmonary_edema1.02283375
61MP0005623_abnormal_meninges_morphology1.01778693
62MP0002064_seizures1.01429152
63MP0010329_abnormal_lipoprotein_level1.00501320
64MP0003191_abnormal_cellular_cholesterol0.97320772
65MP0004043_abnormal_pH_regulation0.96934668
66MP0003252_abnormal_bile_duct0.95712920
67MP0000343_altered_response_to0.94144418
68MP0002734_abnormal_mechanical_nocicepti0.89619735
69MP0002118_abnormal_lipid_homeostasis0.88657772
70MP0005165_increased_susceptibility_to0.88293099
71MP0005319_abnormal_enzyme/_coenzyme0.86767601
72MP0002063_abnormal_learning/memory/cond0.84195864
73MP0009745_abnormal_behavioral_response0.83824922
74MP0005083_abnormal_biliary_tract0.83315084
75MP0005266_abnormal_metabolism0.83255627
76MP0001958_emphysema0.82970165
77MP0002272_abnormal_nervous_system0.82967873
78MP0004510_myositis0.81452861
79MP0003329_amyloid_beta_deposits0.81065161
80MP0003880_abnormal_central_pattern0.80824003
81MP0006035_abnormal_mitochondrial_morpho0.79179962
82MP0000003_abnormal_adipose_tissue0.78915182
83MP0003566_abnormal_cell_adhesion0.78475477
84MP0002909_abnormal_adrenal_gland0.77683883
85MP0005584_abnormal_enzyme/coenzyme_acti0.77314844
86MP0003690_abnormal_glial_cell0.77041778
87MP0004858_abnormal_nervous_system0.76907979
88MP0000230_abnormal_systemic_arterial0.76621298
89MP0000266_abnormal_heart_morphology0.75969861
90MP0009780_abnormal_chondrocyte_physiolo0.75821068
91MP0008961_abnormal_basal_metabolism0.75441136
92MP0002822_catalepsy0.75406625
93MP0004272_abnormal_basement_membrane0.72867323
94MP0009115_abnormal_fat_cell0.71339752
95MP0008875_abnormal_xenobiotic_pharmacok0.68549267
96MP0001486_abnormal_startle_reflex0.67494528
97MP0002078_abnormal_glucose_homeostasis0.65942699
98MP0010368_abnormal_lymphatic_system0.65535717
99MP0005167_abnormal_blood-brain_barrier0.63361192
100MP0002234_abnormal_pharynx_morphology0.62978450
101MP0003045_fibrosis0.62751500
102MP0003011_delayed_dark_adaptation0.62486496
103MP0002249_abnormal_larynx_morphology0.61388040
104MP0003195_calcinosis0.61292104
105MP0002128_abnormal_blood_circulation0.60094210
106* MP0002066_abnormal_motor_capabilities/c0.60066978
107MP0000920_abnormal_myelination0.59731389
108MP0005535_abnormal_body_temperature0.59538819
109MP0004270_analgesia0.57842123
110MP0005334_abnormal_fat_pad0.56833998
111MP0002572_abnormal_emotion/affect_behav0.56463076
112MP0001502_abnormal_circadian_rhythm0.55774907
113MP0001299_abnormal_eye_distance/0.54233960
114MP0002254_reproductive_system_inflammat0.52312435
115MP0001501_abnormal_sleep_pattern0.51172956
116MP0004147_increased_porphyrin_level0.50049209
117MP0005503_abnormal_tendon_morphology0.50041093
118MP0010030_abnormal_orbit_morphology0.49589592
119MP0000609_abnormal_liver_physiology0.49527910
120MP0000767_abnormal_smooth_muscle0.48996718
121MP0004859_abnormal_synaptic_plasticity0.48315416
122MP0008874_decreased_physiological_sensi0.48288505
123MP0001440_abnormal_grooming_behavior0.48157332
124* MP0003634_abnormal_glial_cell0.47560895
125MP0005386_behavior/neurological_phenoty0.47361711
126MP0004924_abnormal_behavior0.47361711
127MP0002896_abnormal_bone_mineralization0.47311991
128MP0003633_abnormal_nervous_system0.46860210
129MP0000762_abnormal_tongue_morphology0.46587097
130MP0002067_abnormal_sensory_capabilities0.44233644

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)6.70484243
2Exercise-induced muscle cramps (HP:0003710)6.24187279
3Calf muscle hypertrophy (HP:0008981)5.40417214
4Muscle hypertrophy of the lower extremities (HP:0008968)5.38685240
5Muscle fiber inclusion bodies (HP:0100299)5.37742396
6Muscle fiber splitting (HP:0003555)5.36143097
7Sudden death (HP:0001699)5.22853828
8Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.17275711
9Type 1 muscle fiber predominance (HP:0003803)5.09085869
10Hyporeflexia of lower limbs (HP:0002600)4.98764519
11Myoglobinuria (HP:0002913)4.95608367
12Abnormality of the calf musculature (HP:0001430)4.58720168
13Nemaline bodies (HP:0003798)4.51554728
14Difficulty running (HP:0009046)4.36700596
15Increased connective tissue (HP:0009025)4.25357791
16EMG: myopathic abnormalities (HP:0003458)4.18597277
17Ventricular tachycardia (HP:0004756)4.02142418
18Asymmetric septal hypertrophy (HP:0001670)3.88342669
19Rhabdomyolysis (HP:0003201)3.73931544
20Abnormality of the left ventricular outflow tract (HP:0011103)3.70384885
21Subaortic stenosis (HP:0001682)3.70384885
22Distal arthrogryposis (HP:0005684)3.58477506
23Myotonia (HP:0002486)3.53372039
24Round ear (HP:0100830)3.50161355
25Muscle stiffness (HP:0003552)3.47245153
26Right ventricular cardiomyopathy (HP:0011663)3.35748863
27Difficulty climbing stairs (HP:0003551)3.32337440
28Lipoatrophy (HP:0100578)3.26998383
29Atrial fibrillation (HP:0005110)3.26872467
30Myopathic facies (HP:0002058)3.20498172
31Increased variability in muscle fiber diameter (HP:0003557)3.18932454
32Abnormality of skeletal muscle fiber size (HP:0012084)3.12636623
33Primary atrial arrhythmia (HP:0001692)3.02826441
34Bundle branch block (HP:0011710)3.00429422
35Supraventricular tachycardia (HP:0004755)2.88836875
36Supraventricular arrhythmia (HP:0005115)2.85394629
37Ulnar deviation of the wrist (HP:0003049)2.79372664
38Dilated cardiomyopathy (HP:0001644)2.77118095
39Ketoacidosis (HP:0001993)2.73574526
40Neck muscle weakness (HP:0000467)2.66761646
41Heart block (HP:0012722)2.62965941
42Hyperglycinuria (HP:0003108)2.61102791
43Palpitations (HP:0001962)2.60231151
44* Ventricular arrhythmia (HP:0004308)2.59907876
45Bulbar palsy (HP:0001283)2.58619035
46Abnormal atrioventricular conduction (HP:0005150)2.55441752
47Atrioventricular block (HP:0001678)2.53977460
48Distal lower limb muscle weakness (HP:0009053)2.50291873
49Ragged-red muscle fibers (HP:0003200)2.46228177
50Mildly elevated creatine phosphokinase (HP:0008180)2.45814893
51Ketosis (HP:0001946)2.44032298
52EMG: neuropathic changes (HP:0003445)2.35725653
53Areflexia of lower limbs (HP:0002522)2.35179804
54Lower limb amyotrophy (HP:0007210)2.33873341
55Hypoalphalipoproteinemia (HP:0003233)2.31352507
56Scapular winging (HP:0003691)2.29586160
57Calcaneovalgus deformity (HP:0001848)2.26872104
58Abnormality of glycine metabolism (HP:0010895)2.26417363
59Abnormality of serine family amino acid metabolism (HP:0010894)2.26417363
60* Syncope (HP:0001279)2.25450632
61Frequent falls (HP:0002359)2.22537687
62Limb-girdle muscle atrophy (HP:0003797)2.18115644
63Ventricular fibrillation (HP:0001663)2.17469267
64Abnormality of the Achilles tendon (HP:0005109)2.16568005
65Achilles tendon contracture (HP:0001771)2.16418094
66Hypoglycemic coma (HP:0001325)2.12268212
67Muscular dystrophy (HP:0003560)2.10305968
68Spinal rigidity (HP:0003306)2.09244717
69Gout (HP:0001997)2.07775965
70Absent phalangeal crease (HP:0006109)2.07596313
71Generalized muscle weakness (HP:0003324)2.07485758
72Gowers sign (HP:0003391)2.07088147
73Hyperammonemia (HP:0001987)2.05784722
74Abnormality of fatty-acid metabolism (HP:0004359)2.05315780
75* Prolonged QT interval (HP:0001657)2.05023448
76Facial diplegia (HP:0001349)2.04532789
77Deformed tarsal bones (HP:0008119)2.03849230
78Rimmed vacuoles (HP:0003805)2.02915873
79Hypoplastic ischia (HP:0003175)2.00718540
80Myokymia (HP:0002411)1.97460022
81Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.94422498
82Waddling gait (HP:0002515)1.88196490
83Distal lower limb amyotrophy (HP:0008944)1.88121892
84Testicular atrophy (HP:0000029)1.87441439
85Weak cry (HP:0001612)1.86034027
86Double outlet right ventricle (HP:0001719)1.85923127
87Congenital malformation of the right heart (HP:0011723)1.85923127
88Broad metatarsal (HP:0001783)1.84950842
89Respiratory insufficiency due to muscle weakness (HP:0002747)1.83205799
90Left ventricular hypertrophy (HP:0001712)1.82859487
91Dicarboxylic aciduria (HP:0003215)1.82814694
92Abnormality of dicarboxylic acid metabolism (HP:0010995)1.82814694
93Fetal akinesia sequence (HP:0001989)1.82791180
94Centrally nucleated skeletal muscle fibers (HP:0003687)1.82148861
95Cholelithiasis (HP:0001081)1.81811564
96Hypoplastic left heart (HP:0004383)1.81749278
97Xanthomatosis (HP:0000991)1.80729915
98Abnormality of the shoulder girdle musculature (HP:0001435)1.79782960
99Proximal amyotrophy (HP:0007126)1.79578855
100Cerebral aneurysm (HP:0004944)1.79560195
101Hypoplastic heart (HP:0001961)1.79471465
102Abnormality of the ischium (HP:0003174)1.78974422
103Ankle clonus (HP:0011448)1.76655270
104Abnormal finger flexion creases (HP:0006143)1.74798273
105Progressive muscle weakness (HP:0003323)1.73805397
106Hyperglycinemia (HP:0002154)1.73561757
107Hip contracture (HP:0003273)1.73401179
108* Abnormal EKG (HP:0003115)1.73232387
109Foot dorsiflexor weakness (HP:0009027)1.72056877
110Steppage gait (HP:0003376)1.71623197
111Protrusio acetabuli (HP:0003179)1.71102459
112Abnormality of the foot musculature (HP:0001436)1.71054192
113Premature rupture of membranes (HP:0001788)1.70945569
114Slender build (HP:0001533)1.69496759
115Limb-girdle muscle weakness (HP:0003325)1.69053003
116Malignant hyperthermia (HP:0002047)1.67400586
117Dysmetric saccades (HP:0000641)1.62257776
118Exercise intolerance (HP:0003546)1.60104870
119Fatigable weakness (HP:0003473)1.55582338
120Abnormality of the neuromuscular junction (HP:0003398)1.55582338
121Abnormality of the tricuspid valve (HP:0001702)1.54191156
122Sudden cardiac death (HP:0001645)1.53364507
123Abnormality of glycolysis (HP:0004366)1.53010490
124Stridor (HP:0010307)1.50277986
125Abnormality of the calcaneus (HP:0008364)1.49734703

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN5.18495087
2OBSCN5.05203434
3PHKG14.21716920
4PHKG24.21716920
5TRIB33.77810409
6PDK32.72162566
7PDK42.72162566
8BCKDK2.65367704
9LMTK22.60476891
10PKN22.47163458
11NEK12.20340924
12DMPK2.14358124
13PINK12.06225121
14MYLK1.90742215
15PDK21.82716427
16MARK11.81378600
17SIK11.60641742
18PIK3CG1.54864510
19PIK3CA1.53294890
20MAP3K71.45434597
21PRPF4B1.44194331
22RIPK11.43016354
23MUSK1.41017795
24NME11.40124818
25MAP2K31.35687906
26ARAF1.30957468
27NTRK31.24498748
28EEF2K1.23725038
29LATS21.21993905
30LIMK11.21517538
31EPHA41.21072116
32UHMK11.14921149
33MAP2K41.14156219
34TGFBR21.12863849
35ERN11.10460074
36DAPK21.10333829
37STK381.07937089
38MAPKAPK31.06215865
39PDGFRA1.03274453
40PAK30.99587356
41DDR20.99494987
42CAMK1D0.98958016
43CAMK2B0.97354100
44STK38L0.92675520
45PRKAA20.90239510
46PRKAA10.89647248
47PRKD30.88483422
48KSR20.86506904
49PRKD10.86450678
50ROCK10.82329584
51WNK40.82021233
52* MAPK120.80841395
53MAP3K30.80160439
54CAMK1G0.78392483
55PAK60.78026294
56TIE10.76961462
57ILK0.75780240
58MARK20.73894118
59MAP3K90.69335661
60STK240.68839893
61ICK0.67727715
62CDC42BPA0.67512536
63PDPK10.66600289
64LATS10.65996474
65PTK2B0.65793969
66TAOK10.64442802
67SGK4940.61709100
68SGK2230.61709100
69EPHB10.60928951
70PTK60.59057232
71CAMK2D0.57057679
72MAP3K110.55057299
73CCNB10.54927362
74AKT20.53550419
75CDK50.53017872
76NTRK20.52023270
77MAP3K50.50292614
78CAMK40.50218455
79CAMK2G0.50019425
80TESK10.49742916
81BRAF0.49473606
82SGK20.49255579
83MAP3K130.48263098
84GRK70.47951690
85DYRK1B0.47295043
86PDK10.46616756
87DAPK30.46580924
88MAP3K10.45904735
89MAPK110.45244243
90FER0.44252632
91MAP2K10.44192825
92PRKG10.43553356
93BMX0.42369398
94SGK30.41913173
95RET0.41728988
96CAMKK10.41588983
97PRKCH0.41315093
98* MAPK40.40972378
99* MAPK100.40613729
100PRKACG0.39755365
101CAMK10.39523592
102PKN10.39167522
103WNK10.39139301
104ROCK20.39013884
105PRKACB0.38191807
106SMG10.37762777
107MAP2K60.37217023
108RAF10.36563816
109MAPK70.36080724
110CAMK2A0.35942163
111MAP3K40.35076745
112FGFR40.34830628
113PAK20.34627037
114MOS0.34581483
115STK110.34011529
116MTOR0.33479959
117RPS6KA20.33249885
118NEK90.33081710
119TRPM70.33074643
120NTRK10.32808643
121TAOK20.31690481
122FLT30.31186451
123GRK50.31091098
124TYRO30.31033923
125RPS6KL10.31019521
126RPS6KC10.31019521
127PRKACA0.30992922
128PRKG20.30256927
129SGK10.29286633
130RPS6KA30.28871086
131EPHB20.28369529
132PTK20.28298439
133MAP3K100.26762733

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.97796175
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.61186408
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.06171580
4Nitrogen metabolism_Homo sapiens_hsa009103.02020691
5Propanoate metabolism_Homo sapiens_hsa006402.95405735
6Fatty acid degradation_Homo sapiens_hsa000712.85002811
7Cardiac muscle contraction_Homo sapiens_hsa042602.51030585
8Dilated cardiomyopathy_Homo sapiens_hsa054142.45398320
9Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.42229491
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.38450893
11Fatty acid metabolism_Homo sapiens_hsa012122.37976781
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.19485079
13Carbon metabolism_Homo sapiens_hsa012002.17782011
14Arginine biosynthesis_Homo sapiens_hsa002201.97819282
15Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.86993267
16PPAR signaling pathway_Homo sapiens_hsa033201.86363591
17Pyruvate metabolism_Homo sapiens_hsa006201.85258423
18Butanoate metabolism_Homo sapiens_hsa006501.72443745
19Fatty acid biosynthesis_Homo sapiens_hsa000611.70076585
20Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.67748438
21Long-term potentiation_Homo sapiens_hsa047201.51164052
22Biosynthesis of amino acids_Homo sapiens_hsa012301.48344367
23Starch and sucrose metabolism_Homo sapiens_hsa005001.44187176
24Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.41114246
25Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.40783920
26Tryptophan metabolism_Homo sapiens_hsa003801.33773867
27Circadian entrainment_Homo sapiens_hsa047131.29484193
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.23709702
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.22783671
30Parkinsons disease_Homo sapiens_hsa050121.22285148
31Primary bile acid biosynthesis_Homo sapiens_hsa001201.19778683
32Amphetamine addiction_Homo sapiens_hsa050311.18819330
33Oxidative phosphorylation_Homo sapiens_hsa001901.18598938
34Adipocytokine signaling pathway_Homo sapiens_hsa049201.15907470
35Synaptic vesicle cycle_Homo sapiens_hsa047211.15083764
36Bile secretion_Homo sapiens_hsa049761.13685086
37Glucagon signaling pathway_Homo sapiens_hsa049221.12950609
38Peroxisome_Homo sapiens_hsa041461.12229999
39beta-Alanine metabolism_Homo sapiens_hsa004101.10734902
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.07565062
41Arginine and proline metabolism_Homo sapiens_hsa003301.05379712
42Insulin resistance_Homo sapiens_hsa049311.05036610
43Alzheimers disease_Homo sapiens_hsa050100.99716145
44Fatty acid elongation_Homo sapiens_hsa000620.98231538
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.97727086
46Insulin signaling pathway_Homo sapiens_hsa049100.96147110
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.88549827
48Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.87419191
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.83103009
50Galactose metabolism_Homo sapiens_hsa000520.83005401
51Fructose and mannose metabolism_Homo sapiens_hsa000510.82992778
52Cholinergic synapse_Homo sapiens_hsa047250.82626697
53AMPK signaling pathway_Homo sapiens_hsa041520.79839970
54Morphine addiction_Homo sapiens_hsa050320.75618468
55Dopaminergic synapse_Homo sapiens_hsa047280.75092519
56Melanogenesis_Homo sapiens_hsa049160.74346362
57Phenylalanine metabolism_Homo sapiens_hsa003600.73308288
58Oxytocin signaling pathway_Homo sapiens_hsa049210.71786779
59Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.71341592
60cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71092043
61Glutamatergic synapse_Homo sapiens_hsa047240.70315752
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69157072
63Complement and coagulation cascades_Homo sapiens_hsa046100.69084803
64Vitamin B6 metabolism_Homo sapiens_hsa007500.68728070
65Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.65549696
66Glioma_Homo sapiens_hsa052140.65434133
67Cocaine addiction_Homo sapiens_hsa050300.65242718
68Gastric acid secretion_Homo sapiens_hsa049710.64727302
69Focal adhesion_Homo sapiens_hsa045100.62714198
70Calcium signaling pathway_Homo sapiens_hsa040200.62351555
71Glycerolipid metabolism_Homo sapiens_hsa005610.61116229
72Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61006336
73VEGF signaling pathway_Homo sapiens_hsa043700.60159189
74Viral myocarditis_Homo sapiens_hsa054160.60007171
75Fat digestion and absorption_Homo sapiens_hsa049750.59824491
76Thyroid hormone synthesis_Homo sapiens_hsa049180.59607901
77Central carbon metabolism in cancer_Homo sapiens_hsa052300.58565807
78Lysine degradation_Homo sapiens_hsa003100.57823088
79Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57382958
80Huntingtons disease_Homo sapiens_hsa050160.57247070
81Gap junction_Homo sapiens_hsa045400.55256187
82Circadian rhythm_Homo sapiens_hsa047100.53575139
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53462486
84Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.52355640
85Pancreatic secretion_Homo sapiens_hsa049720.51887560
86Cysteine and methionine metabolism_Homo sapiens_hsa002700.49142081
87Tight junction_Homo sapiens_hsa045300.49125125
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48981258
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.48920628
90Estrogen signaling pathway_Homo sapiens_hsa049150.47895003
91Ovarian steroidogenesis_Homo sapiens_hsa049130.47772292
92Caffeine metabolism_Homo sapiens_hsa002320.46938341
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46886447
94ECM-receptor interaction_Homo sapiens_hsa045120.46534271
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45181877
96Nicotine addiction_Homo sapiens_hsa050330.45141386
97Tyrosine metabolism_Homo sapiens_hsa003500.43712695
98Renin secretion_Homo sapiens_hsa049240.43124173
99Pentose phosphate pathway_Homo sapiens_hsa000300.41775821
100MAPK signaling pathway_Homo sapiens_hsa040100.41690459
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.40801805
102Histidine metabolism_Homo sapiens_hsa003400.39153687
103HIF-1 signaling pathway_Homo sapiens_hsa040660.38705001
104Neurotrophin signaling pathway_Homo sapiens_hsa047220.38700841
105Insulin secretion_Homo sapiens_hsa049110.38455698
106GnRH signaling pathway_Homo sapiens_hsa049120.36815124
107Salivary secretion_Homo sapiens_hsa049700.36339306
108Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.35617180
109Long-term depression_Homo sapiens_hsa047300.34021536
110Prion diseases_Homo sapiens_hsa050200.33611998
111Type II diabetes mellitus_Homo sapiens_hsa049300.33494375
112Inositol phosphate metabolism_Homo sapiens_hsa005620.33489373
113ABC transporters_Homo sapiens_hsa020100.32930089
114ErbB signaling pathway_Homo sapiens_hsa040120.32381603
115cAMP signaling pathway_Homo sapiens_hsa040240.31071143
116Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.30661741
117Amoebiasis_Homo sapiens_hsa051460.30266687
118Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.30232184
119Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.29786385
120Aldosterone synthesis and secretion_Homo sapiens_hsa049250.29305322
121Staphylococcus aureus infection_Homo sapiens_hsa051500.28877387
122Chemical carcinogenesis_Homo sapiens_hsa052040.28238096
123mTOR signaling pathway_Homo sapiens_hsa041500.27898107
124Sulfur relay system_Homo sapiens_hsa041220.25717143
125Sulfur metabolism_Homo sapiens_hsa009200.25190851
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.24760795
127GABAergic synapse_Homo sapiens_hsa047270.23961409
128Protein digestion and absorption_Homo sapiens_hsa049740.23943236
129Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23548100
130Thyroid hormone signaling pathway_Homo sapiens_hsa049190.23490786
131Metabolic pathways_Homo sapiens_hsa011000.23300138

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