SNTB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Dystrophin is a large, rod-like cytoskeletal protein found at the inner surface of muscle fibers. Dystrophin is missing in Duchenne Muscular Dystrophy patients and is present in reduced amounts in Becker Muscular Dystrophy patients. The protein encoded by this gene is a peripheral membrane protein found associated with dystrophin and dystrophin-related proteins. This gene is a member of the syntrophin gene family, which contains at least two other structurally-related genes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.72206429
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.72206429
3L-phenylalanine metabolic process (GO:0006558)6.41609429
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.41609429
5alpha-linolenic acid metabolic process (GO:0036109)5.96116063
6aromatic amino acid family catabolic process (GO:0009074)5.93868775
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.75015789
8bile acid biosynthetic process (GO:0006699)5.35885037
9urea cycle (GO:0000050)5.30478454
10urea metabolic process (GO:0019627)5.30478454
11kynurenine metabolic process (GO:0070189)5.26538419
12tryptophan catabolic process (GO:0006569)5.25358878
13indole-containing compound catabolic process (GO:0042436)5.25358878
14indolalkylamine catabolic process (GO:0046218)5.25358878
15complement activation, alternative pathway (GO:0006957)5.22042115
16sulfur amino acid catabolic process (GO:0000098)5.11509029
17glyoxylate metabolic process (GO:0046487)5.11388768
18cysteine metabolic process (GO:0006534)5.08368933
19negative regulation of fibrinolysis (GO:0051918)5.02795679
20fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.02448343
21regulation of protein activation cascade (GO:2000257)5.01656905
22tryptophan metabolic process (GO:0006568)4.97318303
23peptidyl-glutamic acid carboxylation (GO:0017187)4.88425780
24protein carboxylation (GO:0018214)4.88425780
25regulation of apoptotic cell clearance (GO:2000425)4.86327395
26nitrogen cycle metabolic process (GO:0071941)4.84505983
27high-density lipoprotein particle remodeling (GO:0034375)4.84003129
28regulation of fibrinolysis (GO:0051917)4.76045714
29regulation of complement activation (GO:0030449)4.71607844
30regulation of triglyceride catabolic process (GO:0010896)4.71312019
31homocysteine metabolic process (GO:0050667)4.69753113
32bile acid metabolic process (GO:0008206)4.62574832
33serine family amino acid catabolic process (GO:0009071)4.58743768
34blood coagulation, intrinsic pathway (GO:0007597)4.58694735
35lysine catabolic process (GO:0006554)4.55911006
36lysine metabolic process (GO:0006553)4.55911006
37plasma lipoprotein particle clearance (GO:0034381)4.52993445
38plasma lipoprotein particle organization (GO:0071827)4.47412052
39triglyceride homeostasis (GO:0070328)4.45643740
40acylglycerol homeostasis (GO:0055090)4.45643740
41amino-acid betaine metabolic process (GO:0006577)4.43309162
42tyrosine metabolic process (GO:0006570)4.43167284
43positive regulation of fatty acid beta-oxidation (GO:0032000)4.40943251
44reverse cholesterol transport (GO:0043691)4.31367075
45protein-lipid complex subunit organization (GO:0071825)4.30500218
46aromatic amino acid family metabolic process (GO:0009072)4.29850593
47protein-lipid complex remodeling (GO:0034368)4.28062369
48macromolecular complex remodeling (GO:0034367)4.28062369
49plasma lipoprotein particle remodeling (GO:0034369)4.28062369
50alpha-amino acid catabolic process (GO:1901606)4.20672338
51positive regulation of extracellular matrix organization (GO:1903055)4.20017788
52regulation of cholesterol esterification (GO:0010872)4.19427648
53phospholipid efflux (GO:0033700)4.12684648
54valine metabolic process (GO:0006573)4.10021271
55intestinal cholesterol absorption (GO:0030299)4.06945761
56positive regulation of lipid catabolic process (GO:0050996)4.06565763
57acetyl-CoA metabolic process (GO:0006084)4.05893146
58negative regulation of cholesterol transport (GO:0032375)4.04220670
59negative regulation of sterol transport (GO:0032372)4.04220670
60negative regulation of protein activation cascade (GO:2000258)4.03643676
61ethanol oxidation (GO:0006069)4.02741235
62positive regulation of hemostasis (GO:1900048)4.01794021
63positive regulation of blood coagulation (GO:0030194)4.01794021
64glycine metabolic process (GO:0006544)3.93587781
65phospholipid homeostasis (GO:0055091)3.93325349
66coenzyme catabolic process (GO:0009109)3.93193046
67cellular amino acid catabolic process (GO:0009063)3.91834426
68regulation of humoral immune response (GO:0002920)3.90593548
69bile acid and bile salt transport (GO:0015721)3.87773783
702-oxoglutarate metabolic process (GO:0006103)3.84368529
71fatty acid beta-oxidation (GO:0006635)3.82807411
72cellular ketone body metabolic process (GO:0046950)3.79170772
73plasma lipoprotein particle assembly (GO:0034377)3.78890282
74regulation of cholesterol homeostasis (GO:2000188)3.78627735
75cholesterol efflux (GO:0033344)3.76108614
76positive regulation of coagulation (GO:0050820)3.74954821
77serine family amino acid metabolic process (GO:0009069)3.74407876
78fatty acid oxidation (GO:0019395)3.74023061
79cellular modified amino acid catabolic process (GO:0042219)3.73693699
80acute-phase response (GO:0006953)3.72808298
81regulation of fatty acid beta-oxidation (GO:0031998)3.72676711
82positive regulation of fatty acid biosynthetic process (GO:0045723)3.70847642
83short-chain fatty acid metabolic process (GO:0046459)3.69795785
84glutamate metabolic process (GO:0006536)3.66991358
85lipid oxidation (GO:0034440)3.66248246
86dicarboxylic acid biosynthetic process (GO:0043650)3.65297588
87positive regulation of fatty acid oxidation (GO:0046321)3.64998338
88indolalkylamine metabolic process (GO:0006586)3.64619364
89cytolysis (GO:0019835)3.63937408
90fatty acid catabolic process (GO:0009062)3.63898430
91cellular glucuronidation (GO:0052695)3.62847012
92imidazole-containing compound metabolic process (GO:0052803)3.62328866
93low-density lipoprotein particle clearance (GO:0034383)3.62280811
94protein activation cascade (GO:0072376)3.62268101
95regulation of plasminogen activation (GO:0010755)3.61894342
96benzene-containing compound metabolic process (GO:0042537)3.61626914
97negative regulation of lipase activity (GO:0060192)3.60833072
98positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.59608774
99monocarboxylic acid catabolic process (GO:0072329)3.59493138
100negative regulation of hemostasis (GO:1900047)3.59452633
101negative regulation of blood coagulation (GO:0030195)3.59452633
102fatty acid transmembrane transport (GO:1902001)3.59355603
103carboxylic acid catabolic process (GO:0046395)3.58834383
104organic acid catabolic process (GO:0016054)3.58834383
105cholesterol homeostasis (GO:0042632)3.56598609
106serine family amino acid biosynthetic process (GO:0009070)3.52541431
107fibrinolysis (GO:0042730)3.52178653
108sterol homeostasis (GO:0055092)3.50514524
109very-low-density lipoprotein particle assembly (GO:0034379)3.50127837
110low-density lipoprotein particle remodeling (GO:0034374)3.49720821
111protein-lipid complex assembly (GO:0065005)3.49271872
112amine catabolic process (GO:0009310)3.48884282
113cellular biogenic amine catabolic process (GO:0042402)3.48884282
114complement activation (GO:0006956)3.45792286
115pinocytosis (GO:0006907)3.45646399
116positive regulation of triglyceride lipase activity (GO:0061365)3.45287730
117positive regulation of lipoprotein lipase activity (GO:0051006)3.45287730
118arginine metabolic process (GO:0006525)3.38057645
119regulation of cholesterol metabolic process (GO:0090181)3.37769006
120lipoprotein metabolic process (GO:0042157)3.31717897
121sterol transport (GO:0015918)3.28176319
122cholesterol transport (GO:0030301)3.28176319
123negative regulation of coagulation (GO:0050819)3.27638334
124negative regulation of complement activation (GO:0045916)3.27036609
125negative regulation of lipid transport (GO:0032369)3.26809694
126ethanol metabolic process (GO:0006067)3.23145199
127positive regulation of steroid metabolic process (GO:0045940)3.20330519
128negative regulation of humoral immune response (GO:0002921)3.18512504
129negative regulation of wound healing (GO:0061045)3.16932841
130complement activation, classical pathway (GO:0006958)3.12601956
131regulation of cholesterol storage (GO:0010885)3.10651546
132regulation of fatty acid biosynthetic process (GO:0042304)3.01879916
133detection of molecule of bacterial origin (GO:0032490)2.95920114
134regulation of cholesterol biosynthetic process (GO:0045540)2.90991041
135regulation of extracellular matrix organization (GO:1903053)2.89279650
136regulation of bile acid biosynthetic process (GO:0070857)2.87822585
137acute inflammatory response (GO:0002526)2.81623231
138positive regulation of phagocytosis (GO:0050766)2.80609408
139negative regulation of fatty acid biosynthetic process (GO:0045717)2.79909629
140positive regulation of wound healing (GO:0090303)2.76725189
141disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.74288085
142killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.74288085
143acylglycerol catabolic process (GO:0046464)2.73102753
144neutral lipid catabolic process (GO:0046461)2.73102753
145intestinal absorption (GO:0050892)2.71045917
146oligosaccharide catabolic process (GO:0009313)2.69637247
147diacylglycerol metabolic process (GO:0046339)2.68091800
148regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.66495972
149epoxygenase P450 pathway (GO:0019373)2.63175887
150progesterone metabolic process (GO:0042448)2.62095004

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.51190859
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.56334741
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.36495751
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.05296835
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.69159491
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.77908099
7* CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.16901909
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.01348865
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.16837194
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.85808479
11CLOCK_20551151_ChIP-Seq_293T_Human2.60817357
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.27473690
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.23708209
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.11218232
15TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.00099455
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.4491969
17IRF8_27001747_Chip-Seq_BMDM_Mouse1.94794371
18BP1_19119308_ChIP-ChIP_Hs578T_Human1.92061156
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.83108113
20HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.74697358
21* FOXA2_19822575_ChIP-Seq_HepG2_Human1.73884327
22GATA1_22025678_ChIP-Seq_K562_Human1.72763537
23SCL_19346495_ChIP-Seq_HPC-7_Human1.71691329
24* VDR_24763502_ChIP-Seq_THP-1_Human1.70283893
25EGR1_19374776_ChIP-ChIP_THP-1_Human1.66377660
26TCF7_22412390_ChIP-Seq_EML_Mouse1.51286982
27VDR_21846776_ChIP-Seq_THP-1_Human1.50540603
28ZNF263_19887448_ChIP-Seq_K562_Human1.49757931
29* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.48608628
30RARG_19884340_ChIP-ChIP_MEFs_Mouse1.43791847
31* VDR_24787735_ChIP-Seq_THP-1_Human1.41911114
32STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.41904743
33SPI1_23127762_ChIP-Seq_K562_Human1.38796838
34IRF8_22096565_ChIP-ChIP_GC-B_Human1.37838540
35TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.36822862
36IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.34932333
37NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.31028481
38* HNF4A_19822575_ChIP-Seq_HepG2_Human1.30705402
39RUNX1_22412390_ChIP-Seq_EML_Mouse1.30442075
40THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.30122964
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27273734
42ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.26914447
43RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.25652455
44ESR2_21235772_ChIP-Seq_MCF-7_Human1.25262659
45MYC_22102868_ChIP-Seq_BL_Human1.22057248
46CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.19738049
47IRF8_21731497_ChIP-ChIP_J774_Mouse1.19656217
48* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.19035979
49SOX2_27498859_Chip-Seq_STOMACH_Mouse1.17267909
50KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.17241297
51VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.16565240
52CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.16305124
53KDM2B_26808549_Chip-Seq_SUP-B15_Human1.15226046
54TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.11711788
55ESR1_20079471_ChIP-ChIP_T-47D_Human1.10478464
56SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10119753
57GATA1_22383799_ChIP-Seq_G1ME_Mouse1.08064253
58GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08022217
59* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.02745047
60FOXO3_23340844_ChIP-Seq_DLD1_Human1.02233501
61STAT4_19710469_ChIP-ChIP_TH1__Mouse1.01423586
62PU_27001747_Chip-Seq_BMDM_Mouse1.00856508
63* MAF_26560356_Chip-Seq_TH1_Human1.00486517
64ELK3_25401928_ChIP-Seq_HUVEC_Human1.00200846
65GATA4_25053715_ChIP-Seq_YYC3_Human0.99922279
66BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99658543
67LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.99228503
68GATA2_22383799_ChIP-Seq_G1ME_Mouse0.99106011
69* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.98970570
70* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96980258
71NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.96726677
72HTT_18923047_ChIP-ChIP_STHdh_Human0.96641147
73SPI1_23547873_ChIP-Seq_NB4_Human0.95350150
74ESR1_21235772_ChIP-Seq_MCF-7_Human0.95258624
75TP63_17297297_ChIP-ChIP_HaCaT_Human0.95058416
76CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94569015
77RXRA_24833708_ChIP-Seq_LIVER_Mouse0.93950523
78Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.93067178
79PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.91813630
80PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91022088
81TRIM28_21343339_ChIP-Seq_HEK293_Human0.90215697
82LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.88694127
83GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.87723706
84* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87361892
85RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.87101002
86AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.84721425
87* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83694176
88SALL4_18804426_ChIP-ChIP_XEN_Mouse0.81364171
89TBX20_22080862_ChIP-Seq_HEART_Mouse0.80298136
90TBX20_22328084_ChIP-Seq_HEART_Mouse0.80298136
91PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.77853070
92ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.77418468
93GATA1_19941826_ChIP-Seq_K562_Human0.75787324
94PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.75286764
95FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.73094657
96KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.71141339
97SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.70929639
98NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.70637246
99NRF2_20460467_ChIP-Seq_MEFs_Mouse0.70637246
100LXR_22292898_ChIP-Seq_THP-1_Human0.69731980
101ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.68057316
102GATA2_19941826_ChIP-Seq_K562_Human0.67992733
103AUTS2_25519132_ChIP-Seq_293T-REX_Human0.67896254
104GATA6_25053715_ChIP-Seq_YYC3_Human0.67184883
105PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.65623017
106ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.64763826
107FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.64390964
108ESR1_15608294_ChIP-ChIP_MCF-7_Human0.64353066
109* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.63483169
110* CEBPB_22108803_ChIP-Seq_LS180_Human0.62672895
111* FOXA1_25552417_ChIP-Seq_VCAP_Human0.62335071
112SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.61064791
113FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.60982463
114GATA3_24758297_ChIP-Seq_MCF-7_Human0.60925024
115GATA2_21666600_ChIP-Seq_HMVEC_Human0.60912847
116SOX2_20726797_ChIP-Seq_SW620_Human0.59056810
117RACK7_27058665_Chip-Seq_MCF-7_Human0.58366429
118SOX9_24532713_ChIP-Seq_HFSC_Mouse0.57156257
119BRD4_27068464_Chip-Seq_AML-cells_Mouse0.57057365
120ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.56348371
121STAT3_1855785_ChIP-Seq_MESCs_Mouse0.56311253
122FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.55890073
123CDX2_20551321_ChIP-Seq_CACO-2_Human0.54921510
124STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.53804420
125NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.53511550
126ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.53144918
127HIF1A_21447827_ChIP-Seq_MCF-7_Human0.53103074
128RARA_24833708_ChIP-Seq_LIVER_Mouse0.53047944
129NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.52199442
130* RUNX_20019798_ChIP-Seq_JUKART_Human0.52082116
131TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.51581970
132EGR1_19032775_ChIP-ChIP_M12_Human0.50095941
133TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.49628722
134KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.49348040
135KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.47499858
136GATA1_19941827_ChIP-Seq_MEL_Mouse0.47179657
137NFIB_24661679_ChIP-Seq_LUNG_Mouse0.46011006
138RARB_24833708_ChIP-Seq_LIVER_Mouse0.45872472
139* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.45213387
140P300_27058665_Chip-Seq_ZR-75-30cells_Human0.44562803
141BCAT_22108803_ChIP-Seq_LS180_Human0.44541127

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.40575611
2MP0005360_urolithiasis6.60143201
3MP0005365_abnormal_bile_salt6.07162495
4MP0005085_abnormal_gallbladder_physiolo5.77382537
5MP0008875_abnormal_xenobiotic_pharmacok4.16767238
6MP0010329_abnormal_lipoprotein_level3.68032544
7MP0003252_abnormal_bile_duct3.62050085
8MP0003806_abnormal_nucleotide_metabolis3.49609056
9MP0005083_abnormal_biliary_tract3.19577442
10MP0009840_abnormal_foam_cell2.73233283
11MP0005058_abnormal_lysosome_morphology2.72734473
12MP0001666_abnormal_nutrient_absorption2.71195606
13MP0003172_abnormal_lysosome_physiology2.47018004
14MP0005332_abnormal_amino_acid2.44506503
15MP0003191_abnormal_cellular_cholesterol2.35068499
16MP0005670_abnormal_white_adipose2.28730792
17MP0000609_abnormal_liver_physiology2.27355705
18MP0002118_abnormal_lipid_homeostasis2.25351187
19MP0003303_peritoneal_inflammation2.15771830
20MP0002132_abnormal_respiratory_system1.97545696
21MP0003705_abnormal_hypodermis_morpholog1.93222450
22MP0003195_calcinosis1.90706303
23MP0005319_abnormal_enzyme/_coenzyme1.80627127
24MP0004019_abnormal_vitamin_homeostasis1.78528815
25MP0003868_abnormal_feces_composition1.77175884
26MP0002138_abnormal_hepatobiliary_system1.76584027
27MP0004130_abnormal_muscle_cell1.69121226
28MP0001915_intracranial_hemorrhage1.65966347
29MP0004883_abnormal_blood_vessel1.54051936
30MP0003950_abnormal_plasma_membrane1.53191270
31MP0003828_pulmonary_edema1.52867470
32MP0002419_abnormal_innate_immunity1.50645117
33MP0005666_abnormal_adipose_tissue1.49292658
34MP0006054_spinal_hemorrhage1.48338162
35MP0001764_abnormal_homeostasis1.44164141
36MP0005584_abnormal_enzyme/coenzyme_acti1.42518297
37MP0002971_abnormal_brown_adipose1.34815272
38MP0003011_delayed_dark_adaptation1.33219976
39MP0002254_reproductive_system_inflammat1.30852164
40MP0006082_CNS_inflammation1.28768266
41MP0002998_abnormal_bone_remodeling1.28044147
42MP0001835_abnormal_antigen_presentation1.25663959
43MP0005397_hematopoietic_system_phenotyp1.23036136
44MP0001545_abnormal_hematopoietic_system1.23036136
45MP0009643_abnormal_urine_homeostasis1.22804887
46MP0002837_dystrophic_cardiac_calcinosis1.22565241
47MP0003186_abnormal_redox_activity1.21497899
48MP0000858_altered_metastatic_potential1.21258015
49MP0003122_maternal_imprinting1.18509461
50MP0001533_abnormal_skeleton_physiology1.17597337
51MP0000598_abnormal_liver_morphology1.17024757
52MP0005025_abnormal_response_to1.15347097
53MP0000685_abnormal_immune_system1.14412852
54MP0003566_abnormal_cell_adhesion1.14392894
55MP0009697_abnormal_copulation1.14000563
56MP0005076_abnormal_cell_differentiation1.13826966
57MP0005451_abnormal_body_composition1.13220230
58MP0005334_abnormal_fat_pad1.09492420
59MP0002876_abnormal_thyroid_physiology1.07720064
60MP0001851_eye_inflammation1.07718894
61MP0005647_abnormal_sex_gland1.07686407
62MP0008004_abnormal_stomach_pH1.06710529
63MP0009763_increased_sensitivity_to1.04986484
64MP0004185_abnormal_adipocyte_glucose1.04724066
65MP0009785_altered_susceptibility_to1.04537762
66MP0010368_abnormal_lymphatic_system1.01580248
67MP0005409_darkened_coat_color1.01497069
68MP0009764_decreased_sensitivity_to0.97641085
69MP0002405_respiratory_system_inflammati0.97084811
70MP0002089_abnormal_postnatal_growth/wei0.97032350
71MP0005375_adipose_tissue_phenotype0.96814432
72MP0003656_abnormal_erythrocyte_physiolo0.95670655
73MP0003075_altered_response_to0.95267028
74MP0001661_extended_life_span0.93444449
75MP0002933_joint_inflammation0.92840569
76MP0000604_amyloidosis0.91865179
77MP0002396_abnormal_hematopoietic_system0.90251821
78MP0005220_abnormal_exocrine_pancreas0.89746021
79MP0009115_abnormal_fat_cell0.87748413
80MP0008438_abnormal_cutaneous_collagen0.87368428
81MP0002078_abnormal_glucose_homeostasis0.86526164
82MP0003183_abnormal_peptide_metabolism0.86007917
83MP0008260_abnormal_autophagy0.85377144
84MP0009333_abnormal_splenocyte_physiolog0.85319981
85MP0008469_abnormal_protein_level0.85111679
86MP0003091_abnormal_cell_migration0.84769432
87MP0005408_hypopigmentation0.84763565
88MP0010155_abnormal_intestine_physiology0.84664801
89MP0001790_abnormal_immune_system0.82729429
90MP0005387_immune_system_phenotype0.82729429
91MP0001845_abnormal_inflammatory_respons0.81800781
92MP0005000_abnormal_immune_tolerance0.81779029
93MP0009642_abnormal_blood_homeostasis0.79490061
94MP0005535_abnormal_body_temperature0.78658767
95MP0005448_abnormal_energy_balance0.77988676
96MP0003724_increased_susceptibility_to0.76639010
97MP0001800_abnormal_humoral_immune0.76098187
98MP0002723_abnormal_immune_serum0.76020890
99MP0010234_abnormal_vibrissa_follicle0.75297749
100MP0002148_abnormal_hypersensitivity_rea0.74727982
101MP0003690_abnormal_glial_cell0.74353398
102MP0003300_gastrointestinal_ulcer0.74247217
103MP0009765_abnormal_xenobiotic_induced0.74215589
104MP0004947_skin_inflammation0.72685380
105MP0002452_abnormal_antigen_presenting0.72472450
106MP0002970_abnormal_white_adipose0.70531241
107MP0009278_abnormal_bone_marrow0.70378452
108MP0006036_abnormal_mitochondrial_physio0.68139605
109MP0001881_abnormal_mammary_gland0.67289558
110MP0005636_abnormal_mineral_homeostasis0.66821549
111MP0005376_homeostasis/metabolism_phenot0.66672375
112MP0000465_gastrointestinal_hemorrhage0.65919275
113MP0009384_cardiac_valve_regurgitation0.65565274
114MP0004808_abnormal_hematopoietic_stem0.65454241
115MP0010630_abnormal_cardiac_muscle0.63851748
116MP0001756_abnormal_urination0.61777402
117MP0002060_abnormal_skin_morphology0.61463598
118MP0003959_abnormal_lean_body0.59984075
119MP0005084_abnormal_gallbladder_morpholo0.59706413
120MP0005275_abnormal_skin_tensile0.59499145
121MP0002796_impaired_skin_barrier0.59465348
122MP0002166_altered_tumor_susceptibility0.55437918
123MP0002168_other_aberrant_phenotype0.53343761
124MP0005266_abnormal_metabolism0.52803809
125MP0001853_heart_inflammation0.52609361
126MP0003436_decreased_susceptibility_to0.51942809
127MP0004272_abnormal_basement_membrane0.51280428
128MP0005248_abnormal_Harderian_gland0.51066526
129MP0009053_abnormal_anal_canal0.50928777
130MP0000003_abnormal_adipose_tissue0.50754128
131MP0005023_abnormal_wound_healing0.48685480
132MP0002136_abnormal_kidney_physiology0.47925653
133MP0004381_abnormal_hair_follicle0.46810435
134MP0003453_abnormal_keratinocyte_physiol0.46598197
135MP0005464_abnormal_platelet_physiology0.46352305
136MP0002269_muscular_atrophy0.45728004
137MP0000639_abnormal_adrenal_gland0.44798620
138MP0005330_cardiomyopathy0.44748007
139MP0009672_abnormal_birth_weight0.43969781
140MP0004782_abnormal_surfactant_physiolog0.42906295
141MP0001243_abnormal_dermal_layer0.42218122
142MP0004264_abnormal_extraembryonic_tissu0.41750214
143MP0003329_amyloid_beta_deposits0.41331522
144MP0003953_abnormal_hormone_level0.40289672
145MP0000249_abnormal_blood_vessel0.40255827
146MP0004087_abnormal_muscle_fiber0.38830823
147MP0005164_abnormal_response_to0.37746903
148MP0002928_abnormal_bile_duct0.37711951
149MP0009780_abnormal_chondrocyte_physiolo0.37446181

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.90152149
2Intrahepatic cholestasis (HP:0001406)6.65711324
3Abnormality of aromatic amino acid family metabolism (HP:0004338)6.29771065
4Xanthomatosis (HP:0000991)6.08614934
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.93160974
6Prolonged partial thromboplastin time (HP:0003645)5.67343856
7Hypobetalipoproteinemia (HP:0003563)5.60805047
8Complement deficiency (HP:0004431)5.38187158
9Hyperlipoproteinemia (HP:0010980)5.17314156
10Epidermoid cyst (HP:0200040)4.65074134
11Hypolipoproteinemia (HP:0010981)4.55479131
12Hyperammonemia (HP:0001987)4.48039827
13Abnormality of the common coagulation pathway (HP:0010990)4.36575553
14Ketosis (HP:0001946)4.31436530
15Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.27309411
16Hypoalphalipoproteinemia (HP:0003233)4.26769878
17Joint hemorrhage (HP:0005261)4.17668684
18Hyperglycinemia (HP:0002154)4.16295381
19Hyperglycinuria (HP:0003108)4.13027098
20Hypoglycemic coma (HP:0001325)4.02408626
21Purpura (HP:0000979)4.00974212
22Abnormality of glycine metabolism (HP:0010895)3.99554801
23Abnormality of serine family amino acid metabolism (HP:0010894)3.99554801
24Fat malabsorption (HP:0002630)3.89531781
25Abnormality of complement system (HP:0005339)3.89385795
26Abnormality of glutamine family amino acid metabolism (HP:0010902)3.85975671
27Abnormality of sulfur amino acid metabolism (HP:0004339)3.84993486
28Abnormality of methionine metabolism (HP:0010901)3.67290328
29Abnormality of aspartate family amino acid metabolism (HP:0010899)3.61561081
30Hypercholesterolemia (HP:0003124)3.59080103
31Abnormality of the intrinsic pathway (HP:0010989)3.58948453
32Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.48507851
33Abnormality of fatty-acid metabolism (HP:0004359)3.44700490
34Myocardial infarction (HP:0001658)3.36068640
35Ketoacidosis (HP:0001993)3.21654335
36Prolonged bleeding time (HP:0003010)3.11319906
37Epistaxis (HP:0000421)3.10331193
38Conjugated hyperbilirubinemia (HP:0002908)3.08950461
39Abnormality of pyrimidine metabolism (HP:0004353)3.05596964
40Skin nodule (HP:0200036)2.99160964
41Hepatocellular carcinoma (HP:0001402)2.93152194
42Steatorrhea (HP:0002570)2.92220814
43Hyperbilirubinemia (HP:0002904)2.86723780
44Abnormality of serum amino acid levels (HP:0003112)2.76811134
45Abnormality of nucleobase metabolism (HP:0010932)2.73241326
46Hypochromic microcytic anemia (HP:0004840)2.63343552
47Hemorrhage of the eye (HP:0011885)2.61221212
48Delayed CNS myelination (HP:0002188)2.59234988
49Abnormality of purine metabolism (HP:0004352)2.57063508
50Esophageal varix (HP:0002040)2.52257927
51Acanthocytosis (HP:0001927)2.51781336
52Spontaneous abortion (HP:0005268)2.51577695
53Exercise-induced myalgia (HP:0003738)2.49974715
54Spastic diplegia (HP:0001264)2.49136350
55Abnormality of dicarboxylic acid metabolism (HP:0010995)2.48666371
56Dicarboxylic aciduria (HP:0003215)2.48666371
57Systemic lupus erythematosus (HP:0002725)2.48103522
58Dysostosis multiplex (HP:0000943)2.46789327
59Increased serum ferritin (HP:0003281)2.46241593
60Metabolic acidosis (HP:0001942)2.45432487
61Hypertriglyceridemia (HP:0002155)2.43891943
62Hypoglycemic seizures (HP:0002173)2.41661619
63Urinary glycosaminoglycan excretion (HP:0003541)2.38531945
64Mucopolysacchariduria (HP:0008155)2.38531945
65Vascular calcification (HP:0004934)2.33708221
66Pancreatitis (HP:0001733)2.32588828
67Abnormality of carpal bone ossification (HP:0006257)2.32385489
68Mitral stenosis (HP:0001718)2.31674196
69Abnormal gallbladder morphology (HP:0012437)2.29907114
70Myositis (HP:0100614)2.29327985
71Protrusio acetabuli (HP:0003179)2.27743867
72Asymmetric septal hypertrophy (HP:0001670)2.27728383
73Cholelithiasis (HP:0001081)2.27168930
74Abnormality of the lumbar spine (HP:0100712)2.27164949
75Abnormal platelet volume (HP:0011876)2.25519339
76Eczematoid dermatitis (HP:0000976)2.23475797
77Flat acetabular roof (HP:0003180)2.23224011
78Orchitis (HP:0100796)2.22831223
79Gout (HP:0001997)2.22515866
80Lethargy (HP:0001254)2.20902642
81Cardiovascular calcification (HP:0011915)2.19647544
82Amyloidosis (HP:0011034)2.18740740
83Optic neuritis (HP:0100653)2.17075195
84Retrobulbar optic neuritis (HP:0100654)2.17075195
85Abnormality of mucopolysaccharide metabolism (HP:0011020)2.16517626
86Abnormality of polysaccharide metabolism (HP:0011012)2.16517626
87Abnormality of glycosaminoglycan metabolism (HP:0004371)2.16517626
88Peritonitis (HP:0002586)2.16061030
89Abnormality of macrophages (HP:0004311)2.15093587
90Abnormal platelet function (HP:0011869)2.12963842
91Impaired platelet aggregation (HP:0003540)2.12963842
92Abnormal cartilage morphology (HP:0002763)2.12743103
93Gingival bleeding (HP:0000225)2.11080354
94Arterial thrombosis (HP:0004420)2.10434374
95Late onset (HP:0003584)2.09626875
96Gastrointestinal infarctions (HP:0005244)2.09349227
97Joint swelling (HP:0001386)2.08872897
98Neonatal onset (HP:0003623)2.06904059
99Recurrent gram-negative bacterial infections (HP:0005420)2.06178326
100Glomerulonephritis (HP:0000099)2.04769836
101Hydroxyprolinuria (HP:0003080)2.03119288
102Abnormality of proline metabolism (HP:0010907)2.03119288
103Thrombophlebitis (HP:0004418)2.01741884
104Sensorimotor neuropathy (HP:0007141)2.00850408
105Hyperglycemia (HP:0003074)1.99802294
106Cerebral edema (HP:0002181)1.96560088
107Rickets (HP:0002748)1.94814051
108Abnormality of glycosphingolipid metabolism (HP:0004343)1.93797573
109Abnormality of glycolipid metabolism (HP:0010969)1.93797573
110Abnormality of liposaccharide metabolism (HP:0010968)1.93797573
111Pigmentary retinal degeneration (HP:0001146)1.92945186
112Irritability (HP:0000737)1.92803104
113Menorrhagia (HP:0000132)1.91149568
114Cholecystitis (HP:0001082)1.89896916
115Abnormal gallbladder physiology (HP:0012438)1.89896916
116Brushfield spots (HP:0001088)1.88792775
117Right ventricular cardiomyopathy (HP:0011663)1.88555980
118Nephritis (HP:0000123)1.87148870
119Abnormality of iron homeostasis (HP:0011031)1.86474096
120Arterial tortuosity (HP:0005116)1.86404123
121Malnutrition (HP:0004395)1.86381083
122Flared iliac wings (HP:0002869)1.86092652
123Hyperinsulinemic hypoglycemia (HP:0000825)1.85875547
124Myoglobinuria (HP:0002913)1.85683978
125Abnormality of the Achilles tendon (HP:0005109)1.84487445
126Abnormality of transition element cation homeostasis (HP:0011030)1.83993613
127Ulnar deviation of the wrist (HP:0003049)1.83264011
128Renal cortical cysts (HP:0000803)1.82888839
129Hypophosphatemic rickets (HP:0004912)1.81814492
130Vomiting (HP:0002013)1.80670147
131Polycythemia (HP:0001901)1.80333703
132Generalized aminoaciduria (HP:0002909)1.78465585
133Nemaline bodies (HP:0003798)1.78240450
134Abnormality of the gallbladder (HP:0005264)1.76669238
135Poikilocytosis (HP:0004447)1.74702295
136Increased cerebral lipofuscin (HP:0011813)1.74286662
137Stroke (HP:0001297)1.73558841
138Elevated hepatic transaminases (HP:0002910)1.72702538
139Enlarged kidneys (HP:0000105)1.72410409
140Increased mean platelet volume (HP:0011877)1.71577564
141Abnormal tarsal ossification (HP:0008369)1.70973824
142Pulmonary embolism (HP:0002204)1.69707477
143Abnormal delivery (HP:0001787)1.69609401
144Abnormal ossification of hand bones (HP:0005921)1.69368221
145Gangrene (HP:0100758)1.66994422
146Ovoid vertebral bodies (HP:0003300)1.66515930
147Osteomalacia (HP:0002749)1.65658766
148Recurrent abscess formation (HP:0002722)1.65508554
149Vacuolated lymphocytes (HP:0001922)1.65338609
150Distal arthrogryposis (HP:0005684)1.65145229
151Vascular tortuosity (HP:0004948)1.63671668
152Broad palm (HP:0001169)1.63504377
153Cerebral aneurysm (HP:0004944)1.63058954
154Small epiphyses (HP:0010585)1.62562517
155Asymmetry of the thorax (HP:0001555)1.61575791
156Cupped ribs (HP:0000887)1.60506074

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.31087832
2SIK14.88618107
3FGFR44.00446883
4TRIB33.72609185
5ERN13.68005646
6PKN22.92426839
7CAMK1D2.51160055
8PRPF4B2.40486883
9INSRR2.33949928
10LATS12.00802689
11MST1R1.92184685
12TAOK31.88160150
13RIPK41.86844438
14CDK121.83934872
15RIPK11.75448287
16PIK3CG1.73292646
17CAMK1G1.64652896
18FLT31.64561213
19PTK61.62867146
20FGFR31.61989737
21FGFR21.58141796
22TYK21.56234915
23JAK11.52765793
24MAP3K101.51785385
25ERBB41.50569707
26MAPK111.49259392
27FRK1.44897860
28EPHB11.43423377
29KIT1.40531070
30MAP3K61.38996865
31CDK61.35314231
32NEK91.31374120
33DDR21.28792592
34MAP3K71.26947257
35MATK1.26257062
36MUSK1.23221692
37PRKAA21.21696846
38JAK21.20734620
39EPHA31.19855063
40BLK1.08730633
41TGFBR21.06308490
42MAP2K41.05614917
43KDR1.05029863
44FGR1.03742710
45MAP3K20.99444855
46SMG10.99182833
47MAP2K30.96946907
48MARK20.96224553
49MAP3K10.95470634
50SYK0.94648688
51TBK10.92657329
52PDGFRA0.91275161
53IRAK40.89382727
54AKT30.86594855
55TIE10.84119226
56PIK3CA0.84073241
57BTK0.83748354
58ERBB20.80527953
59FES0.80215259
60WNK10.80188872
61CSK0.79834286
62MAP3K30.78927861
63DAPK20.78679277
64MTOR0.78156259
65RET0.77974455
66MET0.76018732
67ITK0.75874935
68CDC42BPA0.74090524
69DYRK1B0.73513009
70PDK40.73065619
71PDK30.73065619
72STK240.71287591
73MAPK120.70901785
74JAK30.70620400
75TAOK20.70199191
76HCK0.69121223
77MAP4K10.68735254
78IKBKE0.68569485
79ZAP700.68461824
80MAP2K10.67435997
81SCYL20.67315787
82PTK20.66830944
83GRK60.66760473
84KSR20.66446725
85MOS0.65907569
86LCK0.65881885
87MAP3K140.65215424
88PRKAA10.64592407
89CDK40.63913243
90TTN0.62210207
91SGK20.61613903
92TEC0.61517671
93MAPK150.61454700
94ABL20.60943987
95IRAK10.60231261
96GSK3A0.59708294
97FGFR10.58138988
98STK100.57835694
99LYN0.57327117
100IGF1R0.55643525
101PDPK10.55494001
102SGK30.55376407
103MAP2K60.54765262
104HIPK20.54722785
105LRRK20.53097163
106FER0.51749710
107MAPK40.51431441
108YES10.51188380
109PRKACG0.48887897
110PDK10.47840398
111NLK0.47787058
112PDGFRB0.47080179
113CDK90.46989766
114LMTK20.46655963
115PRKCH0.45751896
116PRKCQ0.45664708
117CSF1R0.45309393
118IRAK30.44802235
119PRKCZ0.42945867
120BMX0.41093498
121ICK0.39978996
122MAPK70.38501612
123CHUK0.37253897
124STK30.37153331
125OBSCN0.35436549
126TXK0.35408775
127MAP3K50.35325415
128EGFR0.33415527
129PRKD10.32454146
130MYLK0.31278779
131EPHA20.30545492
132EEF2K0.30254066
133MELK0.29837337
134TRPM70.29618013
135STK38L0.28786869
136PAK20.27770804
137MAP3K130.27503035

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.28001917
2Nitrogen metabolism_Homo sapiens_hsa009103.69177112
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.13109759
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.09989602
5Arginine biosynthesis_Homo sapiens_hsa002202.94991523
6Fatty acid degradation_Homo sapiens_hsa000712.79304987
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.64262500
8Other glycan degradation_Homo sapiens_hsa005112.60386346
9Complement and coagulation cascades_Homo sapiens_hsa046102.59874193
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.57847094
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.56983821
12Tryptophan metabolism_Homo sapiens_hsa003802.55941428
13Propanoate metabolism_Homo sapiens_hsa006402.41659351
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.40299252
15PPAR signaling pathway_Homo sapiens_hsa033202.30619418
16Fatty acid metabolism_Homo sapiens_hsa012122.18307260
17Peroxisome_Homo sapiens_hsa041462.04912332
18Butanoate metabolism_Homo sapiens_hsa006502.01125012
19Pentose and glucuronate interconversions_Homo sapiens_hsa000402.00668024
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.91083894
21Glycosaminoglycan degradation_Homo sapiens_hsa005311.84672966
22Caffeine metabolism_Homo sapiens_hsa002321.84016905
23beta-Alanine metabolism_Homo sapiens_hsa004101.83842740
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.80435659
25Staphylococcus aureus infection_Homo sapiens_hsa051501.77029046
26Chemical carcinogenesis_Homo sapiens_hsa052041.71242189
27Histidine metabolism_Homo sapiens_hsa003401.69889656
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.69587637
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.61570782
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.56285019
31Phenylalanine metabolism_Homo sapiens_hsa003601.54661864
32Pyruvate metabolism_Homo sapiens_hsa006201.54305410
33Fat digestion and absorption_Homo sapiens_hsa049751.50927480
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.50517179
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.49306005
36Retinol metabolism_Homo sapiens_hsa008301.47212446
37Tyrosine metabolism_Homo sapiens_hsa003501.42276939
38Selenocompound metabolism_Homo sapiens_hsa004501.40899370
39Bile secretion_Homo sapiens_hsa049761.38097905
40Fatty acid biosynthesis_Homo sapiens_hsa000611.30287875
41Starch and sucrose metabolism_Homo sapiens_hsa005001.29596907
42Pertussis_Homo sapiens_hsa051331.28719889
43Carbon metabolism_Homo sapiens_hsa012001.27249255
44Fatty acid elongation_Homo sapiens_hsa000621.24549331
45ABC transporters_Homo sapiens_hsa020101.23773617
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.23523616
47Biosynthesis of amino acids_Homo sapiens_hsa012301.19446154
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.13578693
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.11996815
50Glycerolipid metabolism_Homo sapiens_hsa005611.09585587
51Sulfur metabolism_Homo sapiens_hsa009201.06876874
52Lysosome_Homo sapiens_hsa041421.04477016
53Platelet activation_Homo sapiens_hsa046111.02906733
54Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.99679000
55Folate biosynthesis_Homo sapiens_hsa007900.99610816
56Lysine degradation_Homo sapiens_hsa003100.98345490
57Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.92896480
58Steroid biosynthesis_Homo sapiens_hsa001000.91241731
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.90183370
60Osteoclast differentiation_Homo sapiens_hsa043800.87627867
61Leishmaniasis_Homo sapiens_hsa051400.86898855
62Vitamin B6 metabolism_Homo sapiens_hsa007500.86688081
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79238986
64Sulfur relay system_Homo sapiens_hsa041220.78495127
65Arginine and proline metabolism_Homo sapiens_hsa003300.76734435
66Vitamin digestion and absorption_Homo sapiens_hsa049770.76515201
67Maturity onset diabetes of the young_Homo sapiens_hsa049500.75157466
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73084782
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.71693488
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70858500
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70592966
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.65720227
73Non-small cell lung cancer_Homo sapiens_hsa052230.65612003
74Pancreatic cancer_Homo sapiens_hsa052120.65175814
75B cell receptor signaling pathway_Homo sapiens_hsa046620.64345187
76Malaria_Homo sapiens_hsa051440.62780028
77Pentose phosphate pathway_Homo sapiens_hsa000300.58274161
78Insulin resistance_Homo sapiens_hsa049310.58068042
79Arachidonic acid metabolism_Homo sapiens_hsa005900.57954919
80Chronic myeloid leukemia_Homo sapiens_hsa052200.54668111
81One carbon pool by folate_Homo sapiens_hsa006700.54043233
82Toll-like receptor signaling pathway_Homo sapiens_hsa046200.53592548
83Leukocyte transendothelial migration_Homo sapiens_hsa046700.52428943
84Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.52395269
85Glutathione metabolism_Homo sapiens_hsa004800.52376694
86Tuberculosis_Homo sapiens_hsa051520.50731026
87AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49794403
88Hematopoietic cell lineage_Homo sapiens_hsa046400.49313078
89Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46818650
90TNF signaling pathway_Homo sapiens_hsa046680.45517834
91African trypanosomiasis_Homo sapiens_hsa051430.44219181
92Jak-STAT signaling pathway_Homo sapiens_hsa046300.42683791
93Toxoplasmosis_Homo sapiens_hsa051450.38745023
94AMPK signaling pathway_Homo sapiens_hsa041520.38371728
95Sphingolipid metabolism_Homo sapiens_hsa006000.37129666
96Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.34176809
97Focal adhesion_Homo sapiens_hsa045100.32431279
98Metabolic pathways_Homo sapiens_hsa011000.32249317
99Prion diseases_Homo sapiens_hsa050200.32208795
100Influenza A_Homo sapiens_hsa051640.32096980
101Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.32077970
102NOD-like receptor signaling pathway_Homo sapiens_hsa046210.31748113
103NF-kappa B signaling pathway_Homo sapiens_hsa040640.30796593
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.30235714
105Glucagon signaling pathway_Homo sapiens_hsa049220.29865545
106alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24591282
107Insulin signaling pathway_Homo sapiens_hsa049100.22442563
108Galactose metabolism_Homo sapiens_hsa000520.21944556
109Fructose and mannose metabolism_Homo sapiens_hsa000510.18005290
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.17983357
111Linoleic acid metabolism_Homo sapiens_hsa005910.10919582
112Protein digestion and absorption_Homo sapiens_hsa049740.06539464
113Central carbon metabolism in cancer_Homo sapiens_hsa052300.05046973
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.01481157
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.00863107
116Bladder cancer_Homo sapiens_hsa05219-0.1673465
117Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1636849
118FoxO signaling pathway_Homo sapiens_hsa04068-0.1594804
119Adherens junction_Homo sapiens_hsa04520-0.1436304
120Acute myeloid leukemia_Homo sapiens_hsa05221-0.1369804
121Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1318416
122Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.1195228
123Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.1019154
124Type II diabetes mellitus_Homo sapiens_hsa04930-0.0985187
125ECM-receptor interaction_Homo sapiens_hsa04512-0.0933039
126Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0845835
127Renin-angiotensin system_Homo sapiens_hsa04614-0.0682334
128Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0676847
129Hepatitis C_Homo sapiens_hsa05160-0.0362415
130Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0289699
131Amoebiasis_Homo sapiens_hsa05146-0.0085416

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