SNTB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Dystrophin is a large, rod-like cytoskeletal protein found at the inner surface of muscle fibers. Dystrophin is missing in Duchenne Muscular Dystrophy patients and is present in reduced amounts in Becker Muscular Dystrophy patients. The protein encoded by this gene is a peripheral membrane protein found associated with dystrophin and dystrophin-related proteins. This gene is a member of the syntrophin gene family, which contains at least two other structurally-related genes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)4.86041774
2nuclear pore organization (GO:0006999)4.42001754
3protein heterotrimerization (GO:0070208)4.03227166
4paraxial mesoderm development (GO:0048339)3.75847169
5pericardium development (GO:0060039)3.74940496
6regulation of SMAD protein import into nucleus (GO:0060390)3.73924587
7endodermal cell differentiation (GO:0035987)3.71863260
8collagen fibril organization (GO:0030199)3.71213986
9regulation of hippo signaling (GO:0035330)3.62800706
10pore complex assembly (GO:0046931)3.62640017
11artery development (GO:0060840)3.61351222
12smooth muscle tissue development (GO:0048745)3.49270586
13positive regulation of SMAD protein import into nucleus (GO:0060391)3.47063807
14retina vasculature morphogenesis in camera-type eye (GO:0061299)3.40002830
15kidney mesenchyme development (GO:0072074)3.36125011
16cellular response to vitamin (GO:0071295)3.34032489
17regulation of gene silencing by RNA (GO:0060966)3.33022833
18regulation of posttranscriptional gene silencing (GO:0060147)3.33022833
19regulation of gene silencing by miRNA (GO:0060964)3.33022833
20basement membrane organization (GO:0071711)3.30696464
21axon extension involved in axon guidance (GO:0048846)3.28317411
22neuron projection extension involved in neuron projection guidance (GO:1902284)3.28317411
23metanephric mesenchyme development (GO:0072075)3.27499762
24cell adhesion mediated by integrin (GO:0033627)3.24994404
25endocardial cushion development (GO:0003197)3.24981314
26wound healing, spreading of epidermal cells (GO:0035313)3.20904680
27negative regulation of axon extension involved in axon guidance (GO:0048843)3.20782291
28cellular response to vitamin D (GO:0071305)3.20657562
29mesenchymal-epithelial cell signaling (GO:0060638)3.19782523
30vascular endothelial growth factor signaling pathway (GO:0038084)3.18382426
31regulation of mitotic spindle organization (GO:0060236)3.13941380
32UDP-N-acetylglucosamine metabolic process (GO:0006047)3.13213746
33regulation of protein polyubiquitination (GO:1902914)3.11677364
34hippo signaling (GO:0035329)3.07395484
35regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.05232443
36regulation of integrin-mediated signaling pathway (GO:2001044)3.04675948
37bone trabecula formation (GO:0060346)2.99745927
38regulation of transforming growth factor beta2 production (GO:0032909)2.99548790
39chondrocyte proliferation (GO:0035988)2.93807453
40regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.91442978
41negative regulation of fatty acid transport (GO:2000192)2.90291920
42endocrine hormone secretion (GO:0060986)2.89605926
43regulation of establishment of cell polarity (GO:2000114)2.89076082
44regulation of establishment or maintenance of cell polarity (GO:0032878)2.88275036
45hemidesmosome assembly (GO:0031581)2.85028173
46collagen metabolic process (GO:0032963)2.83575985
47cellular response to interferon-alpha (GO:0035457)2.83134799
48positive regulation of p38MAPK cascade (GO:1900745)2.81843416
49anterior/posterior axis specification, embryo (GO:0008595)2.80469540
50apoptotic cell clearance (GO:0043277)2.76350961
51regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.75931900
52collagen catabolic process (GO:0030574)2.75919336
53negative regulation of DNA repair (GO:0045738)2.75233111
54mitotic sister chromatid cohesion (GO:0007064)2.75121783
55substrate-dependent cell migration (GO:0006929)2.74070203
56regulation of axon extension involved in axon guidance (GO:0048841)2.72859566
57insulin-like growth factor receptor signaling pathway (GO:0048009)2.71851218
58heterochromatin organization (GO:0070828)2.70184180
59lung lobe morphogenesis (GO:0060463)2.69915750
60positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.68545232
61multicellular organismal macromolecule metabolic process (GO:0044259)2.68009368
62embryonic process involved in female pregnancy (GO:0060136)2.67359436
63regulation of integrin activation (GO:0033623)2.67282030
64cell migration involved in heart development (GO:0060973)2.66338906
65lymph vessel development (GO:0001945)2.64081543
66SMAD protein complex assembly (GO:0007183)2.63567625
67sprouting angiogenesis (GO:0002040)2.63102045
68chondrocyte development (GO:0002063)2.61981670
69glomerular basement membrane development (GO:0032836)2.61285661
70negative regulation of axon guidance (GO:1902668)2.60426024
71cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.59096519
72positive regulation of fibroblast migration (GO:0010763)2.58380219
73positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.58185010
74positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.58185010
75positive regulation of mitotic sister chromatid separation (GO:1901970)2.58185010
76embryonic foregut morphogenesis (GO:0048617)2.58136434
77regulation of spindle organization (GO:0090224)2.57981348
78ganglion development (GO:0061548)2.56038401
79cell migration involved in sprouting angiogenesis (GO:0002042)2.55598947
80mesodermal cell differentiation (GO:0048333)2.55485884
81cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.53327546
82endothelial cell morphogenesis (GO:0001886)2.52971824
83multicellular organismal metabolic process (GO:0044236)2.52598423
84multicellular organismal catabolic process (GO:0044243)2.50724187
85negative chemotaxis (GO:0050919)2.48799173
86plasma membrane repair (GO:0001778)2.47916639
87phospholipid translocation (GO:0045332)2.46733801
88lipid translocation (GO:0034204)2.46733801
89extracellular matrix assembly (GO:0085029)2.46383629
90lung vasculature development (GO:0060426)2.45351359
91negative regulation of keratinocyte proliferation (GO:0010839)2.45310909
92spindle assembly involved in mitosis (GO:0090307)2.44809865
93regulation of chondrocyte differentiation (GO:0032330)2.44084726
94NLS-bearing protein import into nucleus (GO:0006607)2.44030817
95iron ion import (GO:0097286)2.43857262
96mammary gland development (GO:0030879)2.43823525
97mitotic nuclear envelope disassembly (GO:0007077)2.43627550
98negative regulation of BMP signaling pathway (GO:0030514)2.43004033
99cell-substrate junction assembly (GO:0007044)2.41454394
100regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.41373337
101renal filtration (GO:0097205)2.41275843
102extracellular matrix disassembly (GO:0022617)2.41260242
103regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.40344379
104regulation of axon guidance (GO:1902667)2.39443478
105lymphangiogenesis (GO:0001946)2.39281622
106negative regulation of chondrocyte differentiation (GO:0032331)2.38233214
107keratan sulfate catabolic process (GO:0042340)2.38216133
108embryonic placenta development (GO:0001892)2.37868174
109embryonic retina morphogenesis in camera-type eye (GO:0060059)2.36101695
110glomerular visceral epithelial cell development (GO:0072015)2.35982371
111blood vessel maturation (GO:0001955)2.35831104
112skin morphogenesis (GO:0043589)2.34906429
113muscle cell migration (GO:0014812)2.34016035
114antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.32825972
115wound healing, spreading of cells (GO:0044319)2.32749458
116regulation of fibroblast migration (GO:0010762)2.32397322
117nuclear envelope disassembly (GO:0051081)2.32356666
118membrane disassembly (GO:0030397)2.32356666
119positive regulation of endothelial cell migration (GO:0010595)2.32213157
120dermatan sulfate biosynthetic process (GO:0030208)2.31918515
121regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.30697158
122sequestering of extracellular ligand from receptor (GO:0035581)2.30374409
123positive regulation of epithelial to mesenchymal transition (GO:0010718)2.29503868
124regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.29074659
125regulation of focal adhesion assembly (GO:0051893)2.29048889
126regulation of cell-substrate junction assembly (GO:0090109)2.29048889
127epithelial cell-cell adhesion (GO:0090136)2.28798123
128interkinetic nuclear migration (GO:0022027)2.27913683
129fibroblast migration (GO:0010761)2.27574247
130positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)2.27116857
131branching involved in prostate gland morphogenesis (GO:0060442)2.27019222
132glomerular filtration (GO:0003094)2.26991872
133substrate adhesion-dependent cell spreading (GO:0034446)2.26632684
134establishment of apical/basal cell polarity (GO:0035089)2.26624217
135regulation of RNA export from nucleus (GO:0046831)2.25981672
136glomerular epithelial cell development (GO:0072310)2.25816260
137regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.25699297
138positive regulation of endothelial cell apoptotic process (GO:2000353)2.25404186
139replicative senescence (GO:0090399)2.25014926
140positive regulation of cartilage development (GO:0061036)2.24529817
141morphogenesis of an endothelium (GO:0003159)2.24498597
142endothelial tube morphogenesis (GO:0061154)2.24498597
143protein localization to cell surface (GO:0034394)2.24205546
144COPII vesicle coating (GO:0048208)2.23438966
145extracellular regulation of signal transduction (GO:1900115)2.23322395
146polarized epithelial cell differentiation (GO:0030859)2.23039096
147Notch signaling involved in heart development (GO:0061314)2.21961224
148platelet-derived growth factor receptor signaling pathway (GO:0048008)2.21142389
149face morphogenesis (GO:0060325)2.20201096
150dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.19583939
151craniofacial suture morphogenesis (GO:0097094)2.19474225
152blood vessel endothelial cell migration (GO:0043534)2.19147773
153response to laminar fluid shear stress (GO:0034616)2.19057665
154mitotic cytokinesis (GO:0000281)2.17852629
155protein localization to endosome (GO:0036010)2.17402394
156ovulation from ovarian follicle (GO:0001542)2.15811329
157cytoplasmic mRNA processing body assembly (GO:0033962)2.13898949
158protein localization to kinetochore (GO:0034501)2.13721267
159embryonic cranial skeleton morphogenesis (GO:0048701)2.13089516

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.10323375
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.61363236
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.93829774
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.91556119
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.75546701
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.69031414
7TRIM28_21343339_ChIP-Seq_HEK293_Human3.35668518
8SALL1_21062744_ChIP-ChIP_HESCs_Human3.16980116
9KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.86290515
10KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.86290515
11KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.86290515
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.70798066
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.39197193
14NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.35896495
15PIAS1_25552417_ChIP-Seq_VCAP_Human2.33111362
16AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.31031563
17* RARG_19884340_ChIP-ChIP_MEFs_Mouse2.28447361
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.21820350
19* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.18828905
20GBX2_23144817_ChIP-Seq_PC3_Human2.14163103
21SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.10594508
22HIF1A_21447827_ChIP-Seq_MCF-7_Human2.10099091
23ZFP57_27257070_Chip-Seq_ESCs_Mouse2.09082897
24ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.07632313
25BRD4_25478319_ChIP-Seq_HGPS_Human2.05463479
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.05390978
27CLOCK_20551151_ChIP-Seq_293T_Human2.03594638
28AHR_22903824_ChIP-Seq_MCF-7_Human2.02444587
29* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.98465084
30CDX2_19796622_ChIP-Seq_MESCs_Mouse1.90088849
31ARNT_22903824_ChIP-Seq_MCF-7_Human1.84026535
32SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.84016649
33* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.83046770
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.79872522
35SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.78348588
36SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.78348588
37* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.76484490
38* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.75432942
39E2F4_17652178_ChIP-ChIP_JURKAT_Human1.75377249
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.72817895
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.72251552
42CJUN_26792858_Chip-Seq_BT549_Human1.71130214
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.70399875
44AR_21909140_ChIP-Seq_LNCAP_Human1.66774967
45HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.66556433
46* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.65037670
47TP53_18474530_ChIP-ChIP_U2OS_Human1.64839131
48SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.62027404
49* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.61735117
50RBPJ_22232070_ChIP-Seq_NCS_Mouse1.59555791
51* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.56999652
52SMAD4_21799915_ChIP-Seq_A2780_Human1.56400546
53TCF3_18692474_ChIP-Seq_MEFs_Mouse1.54881733
54ESR1_21235772_ChIP-Seq_MCF-7_Human1.54852069
55PPAR_26484153_Chip-Seq_NCI-H1993_Human1.52367090
56POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.51644726
57TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.50963291
58* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.49664367
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45311769
60FOXO3_23340844_ChIP-Seq_DLD1_Human1.44887579
61P300_19829295_ChIP-Seq_ESCs_Human1.44625024
62SALL4_18804426_ChIP-ChIP_XEN_Mouse1.44522803
63CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.43921953
64* STAT3_23295773_ChIP-Seq_U87_Human1.41200055
65CTNNB1_20460455_ChIP-Seq_HCT116_Human1.40691539
66ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.39058892
67STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.38171535
68RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.35261181
69E2F1_21310950_ChIP-Seq_MCF-7_Human1.35009432
70STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.33907707
71SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.32811989
72WT1_19549856_ChIP-ChIP_CCG9911_Human1.32501096
73* UBF1/2_26484160_Chip-Seq_HMECs_Human1.32307179
74* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31896160
75FLI1_27457419_Chip-Seq_LIVER_Mouse1.28839526
76FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.28560833
77TP53_16413492_ChIP-PET_HCT116_Human1.28421381
78NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26776932
79FUS_26573619_Chip-Seq_HEK293_Human1.26719185
80TCF3_18692474_ChIP-Seq_MESCs_Mouse1.26258732
81ESR1_20079471_ChIP-ChIP_T-47D_Human1.25066774
82SOX9_24532713_ChIP-Seq_HFSC_Mouse1.24046741
83KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.21574385
84MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21222189
85SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20850387
86EWS_26573619_Chip-Seq_HEK293_Human1.19029199
87TP63_23658742_ChIP-Seq_EP156T_Human1.18294018
88* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.18114640
89SMAD3_21741376_ChIP-Seq_EPCs_Human1.18005084
90* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.17565192
91AR_25329375_ChIP-Seq_VCAP_Human1.16989968
92FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.16871100
93ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16634529
94STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.15101778
95ER_23166858_ChIP-Seq_MCF-7_Human1.14986781
96TCF4_23295773_ChIP-Seq_U87_Human1.14850808
97RXR_22108803_ChIP-Seq_LS180_Human1.14292671
98* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.13392098
99* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12844911
100ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.12386981
101PCGF2_27294783_Chip-Seq_ESCs_Mouse1.11656955
102* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.11552143
103TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10389049
104PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.09716525
105IRF8_21731497_ChIP-ChIP_J774_Mouse1.09703960
106RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.09616667
107NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.09609106
108CDX2_22108803_ChIP-Seq_LS180_Human1.09225053
109JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09188402
110EP300_21415370_ChIP-Seq_HL-1_Mouse1.07911108
111GATA2_21666600_ChIP-Seq_HMVEC_Human1.07760700
112BRD4_27068464_Chip-Seq_AML-cells_Mouse1.07128916
113TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06640572
114BCAT_22108803_ChIP-Seq_LS180_Human1.06599926
115JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06477172
116BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.06299744
117ISL1_27105846_Chip-Seq_CPCs_Mouse1.06228211
118EZH2_27294783_Chip-Seq_NPCs_Mouse1.05625952
119ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.05151962
120CTBP2_25329375_ChIP-Seq_LNCAP_Human1.04758296
121NANOG_18555785_Chip-Seq_ESCs_Mouse1.04443519
122NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.04162899
123NRF2_20460467_ChIP-Seq_MEFs_Mouse1.04162899
124ELK3_25401928_ChIP-Seq_HUVEC_Human1.03645194
125WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03280639
126EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.03145212
127VDR_22108803_ChIP-Seq_LS180_Human1.01937332
128SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.01859933
129PCGF2_27294783_Chip-Seq_NPCs_Mouse1.01076818
130FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.01069249
131* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01028542
132ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.00714674
133TAF15_26573619_Chip-Seq_HEK293_Human1.00569497
134UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00442851
135NR3C1_23031785_ChIP-Seq_PC12_Mouse0.99926364
136* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.99740893
137TCF4_18268006_ChIP-ChIP_LS174T_Human0.99689263
138KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.98960726
139MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.98561105
140NELFA_20434984_ChIP-Seq_ESCs_Mouse0.97093274
141NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.97019645
142TFEB_21752829_ChIP-Seq_HELA_Human0.96149470
143SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.95064824
144NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.94001161
145ATF3_27146783_Chip-Seq_COLON_Human0.93478622
146IRF8_22096565_ChIP-ChIP_GC-B_Human0.91485558
147WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.91415744
148FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88898534
149TBX3_20139965_ChIP-Seq_ESCs_Mouse0.88088711
150TBX3_20139965_ChIP-Seq_MESCs_Mouse0.85235341
151TCF7_22412390_ChIP-Seq_EML_Mouse0.84925279
152* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.84753532
153EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.84711770
154DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.84491018
155ZFP281_27345836_Chip-Seq_ESCs_Mouse0.84390103
156PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.84141291

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.99288811
2MP0005275_abnormal_skin_tensile3.88590319
3MP0005503_abnormal_tendon_morphology3.84358162
4MP0003705_abnormal_hypodermis_morpholog3.41242360
5MP0009780_abnormal_chondrocyte_physiolo3.02151551
6MP0004272_abnormal_basement_membrane2.92008205
7MP0010352_gastrointestinal_tract_polyps2.69635785
8MP0001958_emphysema2.50715241
9MP0005076_abnormal_cell_differentiation2.45803429
10MP0003279_aneurysm2.28061131
11MP0003566_abnormal_cell_adhesion2.18293990
12MP0005623_abnormal_meninges_morphology1.99494275
13MP0002877_abnormal_melanocyte_morpholog1.92961151
14MP0005023_abnormal_wound_healing1.91222160
15MP0010307_abnormal_tumor_latency1.79739001
16MP0002060_abnormal_skin_morphology1.73651750
17MP0003091_abnormal_cell_migration1.64940151
18MP0005508_abnormal_skeleton_morphology1.62416029
19MP0000733_abnormal_muscle_development1.56995800
20MP0003941_abnormal_skin_development1.54160323
21MP0009278_abnormal_bone_marrow1.53492707
22MP0006054_spinal_hemorrhage1.52636922
23MP0005171_absent_coat_pigmentation1.49545323
24MP0001542_abnormal_bone_strength1.48655541
25MP0000534_abnormal_ureter_morphology1.48568449
26MP0000013_abnormal_adipose_tissue1.47045893
27MP0002108_abnormal_muscle_morphology1.46693511
28MP0003828_pulmonary_edema1.45754332
29MP0009250_abnormal_appendicular_skeleto1.42811260
30MP0000516_abnormal_urinary_system1.42097081
31MP0005367_renal/urinary_system_phenotyp1.42097081
32MP0010368_abnormal_lymphatic_system1.40964607
33MP0003448_altered_tumor_morphology1.40659917
34MP0003937_abnormal_limbs/digits/tail_de1.39676135
35MP0005595_abnormal_vascular_smooth1.39003932
36MP0001299_abnormal_eye_distance/1.37508421
37MP0003942_abnormal_urinary_system1.37504804
38MP0001879_abnormal_lymphatic_vessel1.37157482
39MP0005257_abnormal_intraocular_pressure1.35972066
40MP0004233_abnormal_muscle_weight1.33638130
41MP0005409_darkened_coat_color1.31719742
42MP0003045_fibrosis1.29300618
43MP0002006_tumorigenesis1.29045596
44MP0000427_abnormal_hair_cycle1.27458431
45MP0002166_altered_tumor_susceptibility1.24244169
46MP0000767_abnormal_smooth_muscle1.22677396
47MP0010030_abnormal_orbit_morphology1.22578489
48MP0010234_abnormal_vibrissa_follicle1.18299403
49MP0003755_abnormal_palate_morphology1.17594824
50MP0000858_altered_metastatic_potential1.15938673
51MP0006138_congestive_heart_failure1.15634241
52MP0002938_white_spotting1.11648791
53MP0003300_gastrointestinal_ulcer1.11110409
54MP0002925_abnormal_cardiovascular_devel1.09798485
55MP0002168_other_aberrant_phenotype1.09570294
56MP0002295_abnormal_pulmonary_circulatio1.08487474
57MP0005390_skeleton_phenotype1.08382493
58MP0002282_abnormal_trachea_morphology1.07488052
59MP0002086_abnormal_extraembryonic_tissu1.07041423
60MP0003890_abnormal_embryonic-extraembry1.04297794
61MP0001915_intracranial_hemorrhage1.04296054
62MP0004808_abnormal_hematopoietic_stem1.03961723
63MP0004197_abnormal_fetal_growth/weight/1.03487644
64MP0000003_abnormal_adipose_tissue1.02298076
65MP0000428_abnormal_craniofacial_morphol1.01689586
66MP0003950_abnormal_plasma_membrane0.98616625
67MP0002009_preneoplasia0.97894802
68MP0004858_abnormal_nervous_system0.97784472
69MP0009053_abnormal_anal_canal0.97652406
70MP0003984_embryonic_growth_retardation0.97493919
71MP0000350_abnormal_cell_proliferation0.97484637
72MP0002088_abnormal_embryonic_growth/wei0.97448094
73MP0000749_muscle_degeneration0.96821351
74MP0004134_abnormal_chest_morphology0.96544367
75MP0001672_abnormal_embryogenesis/_devel0.95274256
76MP0005380_embryogenesis_phenotype0.95274256
77MP0000569_abnormal_digit_pigmentation0.93633647
78MP0008007_abnormal_cellular_replicative0.93209051
79MP0001243_abnormal_dermal_layer0.92683705
80MP0003453_abnormal_keratinocyte_physiol0.92012307
81MP0003111_abnormal_nucleus_morphology0.91382233
82MP0010386_abnormal_urinary_bladder0.90988516
83MP0008057_abnormal_DNA_replication0.90160222
84MP0010094_abnormal_chromosome_stability0.90099908
85MP0003724_increased_susceptibility_to0.89943266
86MP0005397_hematopoietic_system_phenotyp0.89857713
87MP0001545_abnormal_hematopoietic_system0.89857713
88MP0004130_abnormal_muscle_cell0.89067812
89MP0001661_extended_life_span0.88600098
90MP0005174_abnormal_tail_pigmentation0.88579593
91MP0002084_abnormal_developmental_patter0.88275692
92MP0004084_abnormal_cardiac_muscle0.88039737
93MP0001614_abnormal_blood_vessel0.87329061
94MP0005164_abnormal_response_to0.87106790
95MP0003077_abnormal_cell_cycle0.86926550
96MP0001348_abnormal_lacrimal_gland0.86058525
97MP0003115_abnormal_respiratory_system0.85937562
98MP0000432_abnormal_head_morphology0.85889583
99MP0003385_abnormal_body_wall0.85392711
100MP0002896_abnormal_bone_mineralization0.84052937
101MP0002998_abnormal_bone_remodeling0.82554225
102MP0002109_abnormal_limb_morphology0.82519885
103MP0000538_abnormal_urinary_bladder0.82376646
104MP0004185_abnormal_adipocyte_glucose0.82121186
105MP0003935_abnormal_craniofacial_develop0.81651966
106MP0008775_abnormal_heart_ventricle0.81533628
107MP0000343_altered_response_to0.81251509
108MP0001533_abnormal_skeleton_physiology0.80735241
109MP0002933_joint_inflammation0.80330599
110MP0001175_abnormal_lung_morphology0.79954457
111MP0002085_abnormal_embryonic_tissue0.79023769
112MP0000371_diluted_coat_color0.78808975
113MP0005197_abnormal_uvea_morphology0.78609945
114MP0003283_abnormal_digestive_organ0.77673940
115MP0000750_abnormal_muscle_regeneration0.77481399
116MP0000762_abnormal_tongue_morphology0.77466971
117MP0005248_abnormal_Harderian_gland0.76308886
118MP0004883_abnormal_blood_vessel0.76091633
119MP0005187_abnormal_penis_morphology0.75874862
120MP0002128_abnormal_blood_circulation0.75577559
121MP0002932_abnormal_joint_morphology0.75515322
122MP0000383_abnormal_hair_follicle0.75414372
123MP0001730_embryonic_growth_arrest0.75401533
124MP0004957_abnormal_blastocyst_morpholog0.75226458
125MP0003567_abnormal_fetal_cardiomyocyte0.75143601
126MP0003786_premature_aging0.75125629
127MP0005408_hypopigmentation0.73650167
128MP0002115_abnormal_skeleton_extremities0.73502898
129MP0002113_abnormal_skeleton_development0.72958584
130MP0004484_altered_response_of0.72503617
131MP0000163_abnormal_cartilage_morphology0.72426405
132MP0005388_respiratory_system_phenotype0.72105201
133MP0002133_abnormal_respiratory_system0.72105201
134MP0001849_ear_inflammation0.70962938
135MP0005620_abnormal_muscle_contractility0.70430788
136MP0010678_abnormal_skin_adnexa0.70103256
137MP0010630_abnormal_cardiac_muscle0.69800370
138MP0002233_abnormal_nose_morphology0.69661046
139MP0001697_abnormal_embryo_size0.69248476
140MP0003303_peritoneal_inflammation0.69139371
141MP0009384_cardiac_valve_regurgitation0.68998059
142MP0005670_abnormal_white_adipose0.68510304
143MP0000751_myopathy0.66844056
144MP0002116_abnormal_craniofacial_bone0.66358510
145MP0000049_abnormal_middle_ear0.65775799
146MP0000372_irregular_coat_pigmentation0.65025605
147MP0003868_abnormal_feces_composition0.64653512
148MP0000462_abnormal_digestive_system0.62272071
149MP0000613_abnormal_salivary_gland0.59872497
150MP0000230_abnormal_systemic_arterial0.59434800
151MP0002697_abnormal_eye_size0.59367543
152MP0002177_abnormal_outer_ear0.59109309

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.44102051
2Ankle contracture (HP:0006466)5.02091331
3Premature rupture of membranes (HP:0001788)4.53856050
4Shallow orbits (HP:0000586)3.92159654
5Cervical subluxation (HP:0003308)3.74629526
6Cerebral aneurysm (HP:0004944)3.54042193
7Broad metatarsal (HP:0001783)3.49491197
8Wrist flexion contracture (HP:0001239)3.36952198
9Aortic dissection (HP:0002647)3.25405804
10Aortic aneurysm (HP:0004942)3.24732601
11Increased connective tissue (HP:0009025)3.23813748
12Atrophic scars (HP:0001075)3.18298124
13Soft skin (HP:0000977)2.95556516
14Follicular hyperkeratosis (HP:0007502)2.94276802
15Genu recurvatum (HP:0002816)2.91441382
16Dilatation of the ascending aorta (HP:0005111)2.81845698
17Bladder diverticulum (HP:0000015)2.76873229
18Mitral valve prolapse (HP:0001634)2.74046593
19Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.60422362
20Short 4th metacarpal (HP:0010044)2.60422362
21Hematochezia (HP:0002573)2.56863209
22Osteolytic defects of the phalanges of the hand (HP:0009771)2.52204152
23Osteolytic defects of the hand bones (HP:0009699)2.52204152
24Syringomyelia (HP:0003396)2.46823187
25Spinal cord lesions (HP:0100561)2.46823187
26Spinal rigidity (HP:0003306)2.38892315
27Absent frontal sinuses (HP:0002688)2.34742045
28Wide anterior fontanel (HP:0000260)2.34263514
29Aortic valve stenosis (HP:0001650)2.32770828
30Aortic regurgitation (HP:0001659)2.30197233
31Wormian bones (HP:0002645)2.27675063
32Fragile skin (HP:0001030)2.24833218
33Spondylolisthesis (HP:0003302)2.24423785
34Vertebral compression fractures (HP:0002953)2.21002327
35Aneurysm (HP:0002617)2.20119485
36Blue sclerae (HP:0000592)2.19251451
37Subacute progressive viral hepatitis (HP:0006572)2.19009574
38Limited hip movement (HP:0008800)2.16859103
39Mitral stenosis (HP:0001718)2.16116475
40Vascular tortuosity (HP:0004948)2.14037314
41Coronal craniosynostosis (HP:0004440)2.08049624
42Joint laxity (HP:0001388)2.06975182
43Peritonitis (HP:0002586)2.03240136
44Natal tooth (HP:0000695)2.02100610
45Type 1 muscle fiber predominance (HP:0003803)1.99926868
46Alopecia of scalp (HP:0002293)1.99711467
47Abnormality of the nasal septum (HP:0000419)1.98918529
48Abnormality of dentin (HP:0010299)1.97845270
49Bowel diverticulosis (HP:0005222)1.95465389
50Fused cervical vertebrae (HP:0002949)1.93664469
51Urethral obstruction (HP:0000796)1.87928310
52Increased corneal curvature (HP:0100692)1.86806547
53Keratoconus (HP:0000563)1.86806547
54Mesomelia (HP:0003027)1.86432599
55Increased number of teeth (HP:0011069)1.85452595
56Hypoplasia of the iris (HP:0007676)1.85342270
57Mildly elevated creatine phosphokinase (HP:0008180)1.85248756
58Hypoplastic ischia (HP:0003175)1.83352034
59Short humerus (HP:0005792)1.82935392
60Abnormality of the 4th metacarpal (HP:0010012)1.82791470
61Hyperextensible skin (HP:0000974)1.82249750
62Asymmetry of the thorax (HP:0001555)1.82146449
63Rectal prolapse (HP:0002035)1.81673800
64Camptodactyly of toe (HP:0001836)1.80713125
65Selective tooth agenesis (HP:0001592)1.78342043
66Overgrowth (HP:0001548)1.77989345
67Striae distensae (HP:0001065)1.77843981
68Neonatal short-limb short stature (HP:0008921)1.77758500
69Hypoplasia of the maxilla (HP:0000327)1.77253729
70Slender build (HP:0001533)1.76807320
71Hypoplasia of the odontoid process (HP:0003311)1.76240284
72Abnormality of the frontal sinuses (HP:0002687)1.74771555
73Myocardial infarction (HP:0001658)1.74243873
74Arterial tortuosity (HP:0005116)1.73840110
75Broad long bones (HP:0005622)1.73827489
76Elbow flexion contracture (HP:0002987)1.73669870
77Distal lower limb amyotrophy (HP:0008944)1.73313851
78Long toe (HP:0010511)1.72865131
79Thin bony cortex (HP:0002753)1.72509717
80Long eyelashes (HP:0000527)1.71103047
81Cardiovascular calcification (HP:0011915)1.71065459
82Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.70992780
83Abnormality of the odontoid process (HP:0003310)1.70048971
84Abnormality of the ischium (HP:0003174)1.69412396
85Ulnar bowing (HP:0003031)1.68776813
86Delayed closure of the anterior fontanelle (HP:0001476)1.67956742
87Gastrointestinal carcinoma (HP:0002672)1.67645521
88Malignant gastrointestinal tract tumors (HP:0006749)1.67645521
89Enlarged penis (HP:0000040)1.67576349
90Persistence of primary teeth (HP:0006335)1.66394578
91Abnormality of the acetabulum (HP:0003170)1.66179216
92Narrow palate (HP:0000189)1.66155321
93Abnormality of the phalanges of the hallux (HP:0010057)1.65838795
94Abnormality of the distal phalanx of the thumb (HP:0009617)1.65541146
95Protruding ear (HP:0000411)1.65232492
96Milia (HP:0001056)1.65193784
97Hip contracture (HP:0003273)1.64721291
98Deep philtrum (HP:0002002)1.63605397
99Abnormal delivery (HP:0001787)1.62978206
100Aplasia/hypoplasia of the humerus (HP:0006507)1.62884119
101Short nail (HP:0001799)1.62671889
102Mitral regurgitation (HP:0001653)1.62461640
103Knee flexion contracture (HP:0006380)1.62351371
104Hypopigmentation of the fundus (HP:0007894)1.62171389
105Preaxial foot polydactyly (HP:0001841)1.60946917
106Short hallux (HP:0010109)1.60600574
107Broad phalanx (HP:0006009)1.60153545
108Pulmonic stenosis (HP:0001642)1.58319724
109Deviation of the thumb (HP:0009603)1.57725066
110Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.57515619
111Bell-shaped thorax (HP:0001591)1.57470582
112Increased density of long bones (HP:0006392)1.57201250
113Sparse lateral eyebrow (HP:0005338)1.56881008
114Biliary tract neoplasm (HP:0100574)1.56467860
115Pulmonary artery stenosis (HP:0004415)1.54942252
116Broad ribs (HP:0000885)1.54842631
117Broad thumb (HP:0011304)1.54491283
118Dislocated radial head (HP:0003083)1.54305779
119Thoracolumbar scoliosis (HP:0002944)1.53754436
120Skull defect (HP:0001362)1.53264942
121Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.52274643
122High pitched voice (HP:0001620)1.51800143
123Broad phalanges of the hand (HP:0009768)1.51713047
124Ovoid vertebral bodies (HP:0003300)1.50916133
125Cutaneous melanoma (HP:0012056)1.50879236
126Bilateral sensorineural hearing impairment (HP:0008619)1.50770442
127Flared iliac wings (HP:0002869)1.50704467
128Bradycardia (HP:0001662)1.50412289
129Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.49969147
130Entropion (HP:0000621)1.49521106
131Advanced eruption of teeth (HP:0006288)1.47955020
132Ectopia lentis (HP:0001083)1.46943399
133Vertebral arch anomaly (HP:0008438)1.46773964
134Aplasia/Hypoplasia of the hallux (HP:0008362)1.46237644
135Inguinal hernia (HP:0000023)1.45468417
136Reduced subcutaneous adipose tissue (HP:0003758)1.45314291
137Hypoventilation (HP:0002791)1.43350199

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.86997721
2TIE13.13842566
3LATS13.06000996
4DDR22.96640088
5MYLK2.77398836
6FRK2.72275835
7EPHA22.55496380
8TTN2.54252510
9STK392.46309653
10PDGFRA2.38138560
11STK32.05502669
12RIPK11.96226301
13BMPR1B1.85442975
14WNK41.80751028
15ZAK1.75486850
16TGFBR21.72241769
17CAMK1D1.61002625
18PTK61.60015988
19PNCK1.56018981
20TRPM71.55663529
21GRK11.52626657
22MST1R1.52204505
23MAP3K31.50334092
24ERBB41.50029914
25NEK21.46900032
26EPHA31.46492010
27MELK1.44858425
28BMX1.43532136
29STK101.42280423
30FGFR21.39913210
31STK381.38038083
32FGFR31.36737964
33RPS6KA41.36247017
34CDC71.35981378
35NUAK11.32543034
36STK38L1.28407479
37CDK61.28312788
38SIK11.26712356
39PAK41.25120169
40TGFBR11.24922899
41MAPKAPK31.21596519
42NEK91.21492496
43WNK11.21307612
44PAK31.20509085
45PDGFRB1.18518812
46ACVR1B1.18027601
47TTK1.15467391
48KDR1.14639873
49MET1.13073297
50PKN21.11212830
51STK241.10299937
52LMTK21.09763155
53PTK21.09601135
54MAP3K101.08772573
55DMPK1.08508837
56PDK21.07868804
57MTOR1.07361795
58ADRBK11.05727852
59MAP3K141.04543027
60CHUK1.02892298
61FER1.02040662
62SCYL21.01623393
63PIM10.99958169
64JAK10.98865023
65CDK70.98655186
66LIMK10.97492867
67PRKD30.96766923
68FGFR10.96381482
69CAMK1G0.94716491
70EIF2AK20.93109224
71PIK3CA0.92638354
72STK40.91519619
73PRKD20.89898830
74PLK30.89622063
75CSK0.88996893
76CAMKK20.87369253
77JAK30.86767738
78BRSK20.86224267
79TAF10.84528164
80LATS20.83641943
81PRKAA20.82357246
82ERN10.81617865
83BRD40.77606922
84PRKCE0.75716354
85ICK0.75413905
86TESK10.73257139
87PBK0.72399617
88WEE10.72145538
89CDK40.71024211
90ATR0.70978641
91MARK30.69203700
92ATM0.67737147
93PLK10.67584028
94PTK2B0.67153963
95PAK20.66588937
96EPHB20.64962388
97CHEK20.64878432
98INSR0.64774061
99PIK3CG0.64594049
100NTRK10.64174650
101ADRBK20.63433159
102MAP2K30.63006790
103NLK0.62913713
104AURKB0.62578570
105FLT30.62473836
106OXSR10.61982913
107IKBKB0.61363947
108GSK3A0.60414552
109CDK80.60303489
110ERBB30.60198986
111MAP2K10.59930164
112SGK20.59882167
113MAP3K80.59840161
114CDK90.58187667
115FGFR40.56909726
116RPS6KB20.55425716
117TYK20.55284314
118AKT30.54789367
119INSRR0.53017638
120MAP3K20.52046303
121BCR0.51278400
122TRIB30.50878511
123EEF2K0.50133647
124SGK30.48779562
125PLK20.48195906
126CHEK10.47614096
127CDC42BPA0.46263253
128EPHB10.45941542
129EIF2AK30.43959964
130MAPK10.42785819
131LRRK20.42688721
132MAP3K60.42417659
133ROCK10.40399375
134ABL20.39730269
135ILK0.39427118
136PRKAA10.38884239
137ABL10.38582164
138MKNK20.38519881
139BRSK10.37914800
140EGFR0.36833982
141PRKCH0.35714733
142CASK0.32125813
143ROCK20.27945363
144RPS6KA20.25720479
145MAPKAPK50.25625471

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.80554533
2Adherens junction_Homo sapiens_hsa045202.46583250
3Focal adhesion_Homo sapiens_hsa045102.18257478
4Small cell lung cancer_Homo sapiens_hsa052222.07528124
5TGF-beta signaling pathway_Homo sapiens_hsa043501.98002736
6MicroRNAs in cancer_Homo sapiens_hsa052061.88417308
7Proteoglycans in cancer_Homo sapiens_hsa052051.79623690
8AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.75280130
9Malaria_Homo sapiens_hsa051441.69280180
10Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.66180580
11p53 signaling pathway_Homo sapiens_hsa041151.62201975
12Amoebiasis_Homo sapiens_hsa051461.58898308
13Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.53336633
14Cell cycle_Homo sapiens_hsa041101.53307546
15Vascular smooth muscle contraction_Homo sapiens_hsa042701.42720791
16Prostate cancer_Homo sapiens_hsa052151.40907754
17Viral myocarditis_Homo sapiens_hsa054161.40654440
18Hippo signaling pathway_Homo sapiens_hsa043901.40587905
19Selenocompound metabolism_Homo sapiens_hsa004501.40144932
20Leukocyte transendothelial migration_Homo sapiens_hsa046701.36950893
21Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.35116653
22Toxoplasmosis_Homo sapiens_hsa051451.34195731
23Leishmaniasis_Homo sapiens_hsa051401.33728268
24Chronic myeloid leukemia_Homo sapiens_hsa052201.33462895
25Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.32800240
26Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.32330950
27NF-kappa B signaling pathway_Homo sapiens_hsa040641.29371916
28TNF signaling pathway_Homo sapiens_hsa046681.28927308
29HTLV-I infection_Homo sapiens_hsa051661.28726662
30Protein digestion and absorption_Homo sapiens_hsa049741.25193653
31Circadian rhythm_Homo sapiens_hsa047101.22273065
32Viral carcinogenesis_Homo sapiens_hsa052031.21366975
33Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.21105302
34PI3K-Akt signaling pathway_Homo sapiens_hsa041511.17938952
35Basal cell carcinoma_Homo sapiens_hsa052171.17512081
36Axon guidance_Homo sapiens_hsa043601.16960168
37Apoptosis_Homo sapiens_hsa042101.16880318
38Pathways in cancer_Homo sapiens_hsa052001.16227736
39Regulation of actin cytoskeleton_Homo sapiens_hsa048101.15706401
40Bladder cancer_Homo sapiens_hsa052191.14071238
41mTOR signaling pathway_Homo sapiens_hsa041501.09191547
42Osteoclast differentiation_Homo sapiens_hsa043801.08982941
43RNA transport_Homo sapiens_hsa030131.07683261
44Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.07553755
45Legionellosis_Homo sapiens_hsa051341.07364947
46Fatty acid biosynthesis_Homo sapiens_hsa000611.05760625
47Notch signaling pathway_Homo sapiens_hsa043301.05413786
48Pancreatic cancer_Homo sapiens_hsa052121.04286364
49Transcriptional misregulation in cancer_Homo sapiens_hsa052021.04187441
50Melanoma_Homo sapiens_hsa052181.03971748
51Hepatitis B_Homo sapiens_hsa051611.02293019
52Herpes simplex infection_Homo sapiens_hsa051681.02003923
53Melanogenesis_Homo sapiens_hsa049161.01949775
54Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.01660527
55Thyroid hormone signaling pathway_Homo sapiens_hsa049190.97105277
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.97098135
57Antigen processing and presentation_Homo sapiens_hsa046120.96038477
58FoxO signaling pathway_Homo sapiens_hsa040680.95886179
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.95167648
60cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93942311
61Systemic lupus erythematosus_Homo sapiens_hsa053220.92751484
62Dorso-ventral axis formation_Homo sapiens_hsa043200.91501845
63Measles_Homo sapiens_hsa051620.91313198
64ABC transporters_Homo sapiens_hsa020100.91197717
65Colorectal cancer_Homo sapiens_hsa052100.91093497
66HIF-1 signaling pathway_Homo sapiens_hsa040660.89665495
67NOD-like receptor signaling pathway_Homo sapiens_hsa046210.88618009
68Central carbon metabolism in cancer_Homo sapiens_hsa052300.85918801
69Dilated cardiomyopathy_Homo sapiens_hsa054140.85319157
70Shigellosis_Homo sapiens_hsa051310.83779148
71AMPK signaling pathway_Homo sapiens_hsa041520.83362642
72Mismatch repair_Homo sapiens_hsa034300.82011531
73Salmonella infection_Homo sapiens_hsa051320.81286985
74Influenza A_Homo sapiens_hsa051640.81073961
75Endometrial cancer_Homo sapiens_hsa052130.80049373
76One carbon pool by folate_Homo sapiens_hsa006700.79242308
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.78046049
78Tight junction_Homo sapiens_hsa045300.75713988
79Hedgehog signaling pathway_Homo sapiens_hsa043400.75650710
80Fanconi anemia pathway_Homo sapiens_hsa034600.75593949
81Toll-like receptor signaling pathway_Homo sapiens_hsa046200.75463370
82Rap1 signaling pathway_Homo sapiens_hsa040150.74874340
83Lysine degradation_Homo sapiens_hsa003100.73433515
84Non-homologous end-joining_Homo sapiens_hsa034500.72842298
85Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.72678078
86Tuberculosis_Homo sapiens_hsa051520.72579713
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71791907
88Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.70675721
89Gap junction_Homo sapiens_hsa045400.70292805
90Platelet activation_Homo sapiens_hsa046110.70008977
91Ovarian steroidogenesis_Homo sapiens_hsa049130.69667699
92Inositol phosphate metabolism_Homo sapiens_hsa005620.69427533
93Thyroid cancer_Homo sapiens_hsa052160.68148490
94Thyroid hormone synthesis_Homo sapiens_hsa049180.67976399
95DNA replication_Homo sapiens_hsa030300.67870562
96Jak-STAT signaling pathway_Homo sapiens_hsa046300.67572216
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67207465
98mRNA surveillance pathway_Homo sapiens_hsa030150.66252331
99Vitamin B6 metabolism_Homo sapiens_hsa007500.65936484
100Glycosaminoglycan degradation_Homo sapiens_hsa005310.65445657
101Insulin resistance_Homo sapiens_hsa049310.65400505
102Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65105443
103Ras signaling pathway_Homo sapiens_hsa040140.64705286
104Phototransduction_Homo sapiens_hsa047440.64283301
105Epstein-Barr virus infection_Homo sapiens_hsa051690.64255065
106Sphingolipid metabolism_Homo sapiens_hsa006000.64224444
107Renal cell carcinoma_Homo sapiens_hsa052110.63924610
108Phagosome_Homo sapiens_hsa041450.63838104
109Wnt signaling pathway_Homo sapiens_hsa043100.63711824
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63506586
111Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63356636
112Glioma_Homo sapiens_hsa052140.63328832
113Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.63150422
114Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62703549
115Calcium signaling pathway_Homo sapiens_hsa040200.62349020
116Acute myeloid leukemia_Homo sapiens_hsa052210.61007929
117Choline metabolism in cancer_Homo sapiens_hsa052310.60556133
118Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.60301340
119Renin secretion_Homo sapiens_hsa049240.59695452
120Staphylococcus aureus infection_Homo sapiens_hsa051500.59156817
121Renin-angiotensin system_Homo sapiens_hsa046140.58987533
122Glucagon signaling pathway_Homo sapiens_hsa049220.58577057
123PPAR signaling pathway_Homo sapiens_hsa033200.57243937
124Glycerolipid metabolism_Homo sapiens_hsa005610.57137630
125Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.56504377
126Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55488200
127Hematopoietic cell lineage_Homo sapiens_hsa046400.55325865
128Complement and coagulation cascades_Homo sapiens_hsa046100.55295904
129Neurotrophin signaling pathway_Homo sapiens_hsa047220.54575315
130Graft-versus-host disease_Homo sapiens_hsa053320.54397652
131Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.54257928
132Basal transcription factors_Homo sapiens_hsa030220.52918855
133Tryptophan metabolism_Homo sapiens_hsa003800.52484275
134cAMP signaling pathway_Homo sapiens_hsa040240.52462795
135MAPK signaling pathway_Homo sapiens_hsa040100.50266503
136alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.50047688
137Ether lipid metabolism_Homo sapiens_hsa005650.50021932
138Estrogen signaling pathway_Homo sapiens_hsa049150.48770165
139Salivary secretion_Homo sapiens_hsa049700.48162494
140Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47852787
141Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46887384
142Oxytocin signaling pathway_Homo sapiens_hsa049210.46418458
143Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45589223
144Adipocytokine signaling pathway_Homo sapiens_hsa049200.45024899
145Mineral absorption_Homo sapiens_hsa049780.44212390
146Long-term depression_Homo sapiens_hsa047300.43986997
147Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.42925017
148Insulin signaling pathway_Homo sapiens_hsa049100.42832568
149N-Glycan biosynthesis_Homo sapiens_hsa005100.41841212

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